locus-tag	class	description
J5A53_RS00005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J5A53_RS00010	COG4608	Belongs to the ABC transporter superfamily
J5A53_RS00015	COG0444	Belongs to the ABC transporter superfamily
J5A53_RS00020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5A53_RS00025	COG0601	transmembrane transport
J5A53_RS00030	COG0747	negative chemotaxis
J5A53_RS00050	COG0640	Transcriptional regulator
J5A53_RS00055	COG2814	Major facilitator Superfamily
J5A53_RS00065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J5A53_RS00070	COG0187	DNA topoisomerase II activity
J5A53_RS00095	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
J5A53_RS00100	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J5A53_RS00110	COG0592	DNA-directed DNA polymerase activity
J5A53_RS00115	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J5A53_RS00120	COG0230	Belongs to the bacterial ribosomal protein bL34 family
J5A53_RS00125	COG0594	ribonuclease P activity
J5A53_RS00130	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J5A53_RS00135	COG0706	membrane insertase activity
J5A53_RS00145	COG0357	Ribosomal RNA small subunit methyltransferase G
J5A53_RS00170	COG1181	Belongs to the D-alanine--D-alanine ligase family
J5A53_RS00190	COG0492	ferredoxin-NADP+ reductase activity
J5A53_RS00215	COG1505	serine-type exopeptidase activity
J5A53_RS00220	COG1024	Enoyl-CoA hydratase
J5A53_RS00230	COG1971	Probably functions as a manganese efflux pump
J5A53_RS00235	COG1321	iron dependent repressor
J5A53_RS00265	COG2267	carboxylic ester hydrolase activity
J5A53_RS00270	COG0783	Belongs to the Dps family
J5A53_RS00280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A53_RS00285	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A53_RS00290	COG1120	ATPase activity
J5A53_RS00305	COG3527	Alpha-acetolactate decarboxylase
J5A53_RS00315	COG0768	penicillin binding
J5A53_RS00345	COG2856	Zn peptidase
J5A53_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J5A53_RS00440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J5A53_RS00450	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J5A53_RS00465	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
J5A53_RS00500	COG0521	Mo-molybdopterin cofactor biosynthetic process
J5A53_RS00500	COG0315	cyclic pyranopterin monophosphate synthase activity
J5A53_RS00505	COG0653	protein targeting
J5A53_RS00510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J5A53_RS00530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J5A53_RS00545	COG0791	NLP P60 protein
J5A53_RS00545	COG3883	PFAM NLP P60 protein
J5A53_RS00605	COG3012	SEC-C Motif Domain Protein
J5A53_RS00620	COG1408	metallophosphoesterase
J5A53_RS00625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J5A53_RS00635	COG0733	neurotransmitter:sodium symporter activity
J5A53_RS00650	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J5A53_RS00660	COG0519	Catalyzes the synthesis of GMP from XMP
J5A53_RS00675	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
J5A53_RS00685	COG1696	Membrane protein involved in D-alanine export
J5A53_RS00690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J5A53_RS00700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J5A53_RS00755	COG3588	fructose-bisphosphate aldolase
J5A53_RS00780	COG3848	Pyruvate phosphate dikinase
J5A53_RS00780	COG0574	Belongs to the PEP-utilizing enzyme family
J5A53_RS00790	COG0442	prolyl-tRNA aminoacylation
J5A53_RS00810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J5A53_RS00835	COG1674	ftsk spoiiie
J5A53_RS00965	COG1215	transferase activity, transferring glycosyl groups
J5A53_RS00985	COG1216	Glycosyl transferase, family 2
J5A53_RS00985	COG0438	transferase activity, transferring glycosyl groups
J5A53_RS01050	COG0039	L-malate dehydrogenase activity
J5A53_RS01065	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
J5A53_RS01080	COG4869	propanediol catabolic process
J5A53_RS01135	COG4917	ethanolamine utilization protein
J5A53_RS01160	COG0789	Transcriptional regulator
J5A53_RS01165	COG0667	Aldo Keto reductase
J5A53_RS01170	COG1129	ABC transporter
J5A53_RS01190	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J5A53_RS01200	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
J5A53_RS01215	COG0137	argininosuccinate synthase activity
J5A53_RS01245	COG1316	TRANSCRIPTIONal
J5A53_RS01265	COG0584	glycerophosphoryl diester phosphodiesterase
J5A53_RS01270	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
J5A53_RS01280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
J5A53_RS01295	COG1621	beta-fructofuranosidase activity
J5A53_RS01310	COG1175	transmembrane transport
J5A53_RS01390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A53_RS01395	COG1120	ATPase activity
J5A53_RS01400	COG1429	ligase activity, forming nitrogen-metal bonds
J5A53_RS01415	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
J5A53_RS01425	COG3655	Transcriptional regulator
J5A53_RS01430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J5A53_RS01440	COG5564	TIM-barrel signal transduction protein
J5A53_RS01485	COG3311	Transcriptional regulator
J5A53_RS01495	COG1715	Restriction endonuclease
J5A53_RS01500	COG0732	type I restriction modification DNA specificity domain
J5A53_RS01525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
J5A53_RS01530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A53_RS01535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A53_RS01540	COG1120	ATPase activity
J5A53_RS01545	COG1132	(ABC) transporter
J5A53_RS01550	COG1132	(ABC) transporter
J5A53_RS01575	COG1131	(ABC) transporter
J5A53_RS01580	COG4585	Histidine kinase
J5A53_RS01585	COG2197	response regulator
J5A53_RS01600	COG0433	COG0433 Predicted ATPase
J5A53_RS01615	COG1120	ATPase activity
J5A53_RS01620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A53_RS01635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A53_RS01640	COG1120	ATPase activity
J5A53_RS01655	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J5A53_RS01675	COG0673	inositol 2-dehydrogenase activity
J5A53_RS01690	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J5A53_RS01725	COG0601	transmembrane transport
J5A53_RS01730	COG0673	inositol 2-dehydrogenase activity
J5A53_RS01760	COG0717	Belongs to the dCTP deaminase family
J5A53_RS01775	COG1132	(ABC) transporter
J5A53_RS01815	COG2375	cellular response to nickel ion
J5A53_RS01815	COG1132	(ABC) transporter
J5A53_RS01825	COG1129	ABC transporter
J5A53_RS01835	COG2814	Major facilitator Superfamily
J5A53_RS01840	COG1021	2,3-dihydroxybenzoate-AMP ligase
J5A53_RS01845	COG1021	2,3-dihydroxybenzoate-AMP ligase
J5A53_RS01860	COG1129	ABC transporter
J5A53_RS01910	COG0318	PFAM AMP-dependent synthetase and ligase
J5A53_RS01920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J5A53_RS01920	COG2226	methyltransferase
J5A53_RS01920	COG3433	isochorismatase activity
J5A53_RS01940	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
J5A53_RS01945	COG2205	protein histidine kinase activity
J5A53_RS01950	COG0745	RESPONSE REGULATOR receiver
J5A53_RS01975	COG1116	anion transmembrane transporter activity
J5A53_RS01980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
J5A53_RS01990	COG1252	NADH dehydrogenase
J5A53_RS01995	COG2211	Major facilitator Superfamily
J5A53_RS02005	COG1609	Transcriptional regulator
J5A53_RS02025	COG1136	(ABC) transporter
J5A53_RS02025	COG0577	efflux transmembrane transporter activity
J5A53_RS02030	COG0577	efflux transmembrane transporter activity
J5A53_RS02030	COG1136	(ABC) transporter
J5A53_RS02075	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
J5A53_RS02080	COG2027	D-alanyl-D-alanine carboxypeptidase
J5A53_RS02110	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J5A53_RS02115	COG0438	transferase activity, transferring glycosyl groups
J5A53_RS02145	COG3263	regulation of cellular component size
J5A53_RS02150	COG2827	Endonuclease containing a URI domain
J5A53_RS02210	COG1468	defense response to virus
J5A53_RS02210	COG1518	maintenance of DNA repeat elements
J5A53_RS02215	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
J5A53_RS02245	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J5A53_RS02250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J5A53_RS02275	COG0515	serine threonine protein kinase
J5A53_RS02280	COG0768	penicillin binding
J5A53_RS02300	COG1716	ATPase activity
J5A53_RS02330	COG1216	Glycosyl transferase, family 2
J5A53_RS02340	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
J5A53_RS02345	COG0656	L-ascorbic acid biosynthetic process
J5A53_RS02350	COG0018	arginyl-trna synthetase
J5A53_RS02365	COG1136	(ABC) transporter
J5A53_RS02370	COG1621	beta-fructofuranosidase activity
J5A53_RS02380	COG0385	Bile acid
J5A53_RS02385	COG1968	undecaprenyl-diphosphatase activity
J5A53_RS02390	COG1940	carbohydrate kinase activity
J5A53_RS02430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J5A53_RS02430	COG1754	DNA topoisomerase type I activity
J5A53_RS02460	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J5A53_RS02465	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J5A53_RS02485	COG1774	PSP1 C-terminal conserved region
J5A53_RS02495	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J5A53_RS02510	COG1722	exodeoxyribonuclease VII activity
J5A53_RS02515	COG1570	exodeoxyribonuclease VII activity
J5A53_RS02530	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J5A53_RS02570	COG0813	purine-nucleoside phosphorylase activity
J5A53_RS02575	COG1322	Protein conserved in bacteria
J5A53_RS02580	COG1362	aminopeptidase activity
J5A53_RS02585	COG0012	GTP binding
J5A53_RS02615	COG1396	sequence-specific DNA binding
J5A53_RS02620	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
J5A53_RS02645	COG0456	acetyltransferase
J5A53_RS02680	COG1733	regulation of RNA biosynthetic process
J5A53_RS02695	COG3226	Transcriptional regulator
J5A53_RS02700	COG2161	toxin-antitoxin pair type II binding
J5A53_RS02705	COG4115	mRNA cleavage
J5A53_RS02715	COG4691	Plasmid stability protein
J5A53_RS02725	COG2814	Major facilitator Superfamily
J5A53_RS02755	COG0477	Major facilitator Superfamily
J5A53_RS02760	COG1309	transcriptional regulator
J5A53_RS02805	COG1234	tRNA 3'-trailer cleavage
J5A53_RS02860	COG0174	glutamine synthetase
J5A53_RS02870	COG0477	Major facilitator Superfamily
J5A53_RS02890	COG0281	malic enzyme
J5A53_RS02905	COG3226	Transcriptional regulator
J5A53_RS02935	COG1970	mechanosensitive ion channel activity
J5A53_RS02950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J5A53_RS03155	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J5A53_RS03160	COG0484	heat shock protein binding
J5A53_RS03165	COG0789	Transcriptional regulator
J5A53_RS03170	COG0366	Alpha amylase catalytic
J5A53_RS03185	COG1175	transmembrane transport
J5A53_RS03190	COG3833	ABC-type maltose transport systems, permease component
J5A53_RS03195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J5A53_RS03210	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J5A53_RS03215	COG2838	Isocitrate dehydrogenase
J5A53_RS03255	COG0166	Belongs to the GPI family
J5A53_RS03300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J5A53_RS03305	COG2011	ABC-type metal ion transport system permease component
J5A53_RS03310	COG1464	Belongs to the NlpA lipoprotein family
J5A53_RS03320	COG1473	amidohydrolase
J5A53_RS03345	COG0560	Phosphoserine phosphatase
J5A53_RS03345	COG3830	Belongs to the UPF0237 family
J5A53_RS03350	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J5A53_RS03355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5A53_RS03365	COG0454	-acetyltransferase
J5A53_RS03365	COG0456	acetyltransferase
J5A53_RS03390	COG2814	Major facilitator Superfamily
J5A53_RS03405	COG0840	transmembrane signaling receptor activity
J5A53_RS03420	COG0515	serine threonine protein kinase
J5A53_RS03445	COG0076	glutamate decarboxylase activity
J5A53_RS03450	COG2056	Na+-H+ antiporter family
J5A53_RS03470	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J5A53_RS03485	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J5A53_RS03490	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
J5A53_RS03510	COG0577	efflux transmembrane transporter activity
J5A53_RS03510	COG1136	(ABC) transporter
J5A53_RS03515	COG1136	(ABC) transporter
J5A53_RS03520	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
J5A53_RS03525	COG2197	response regulator
J5A53_RS03530	COG4585	Histidine kinase
J5A53_RS03585	COG2409	Drug exporters of the RND superfamily
J5A53_RS03610	COG0667	Aldo Keto reductase
J5A53_RS03625	COG1131	(ABC) transporter
J5A53_RS03630	COG4585	Histidine kinase
J5A53_RS03635	COG2197	response regulator
J5A53_RS03645	COG1028	Short-chain dehydrogenase reductase Sdr
J5A53_RS03645	COG3321	synthase
J5A53_RS03645	COG0604	alcohol dehydrogenase
J5A53_RS03700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J5A53_RS03705	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J5A53_RS03720	COG0640	Transcriptional regulator
J5A53_RS03755	COG4166	transmembrane transport
J5A53_RS03760	COG1132	(ABC) transporter
J5A53_RS03765	COG1132	(ABC) transporter
J5A53_RS03765	COG2375	cellular response to nickel ion
J5A53_RS03785	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
J5A53_RS03795	COG1461	Dihydroxyacetone kinase
J5A53_RS03815	COG4948	Mandelate Racemase Muconate Lactonizing
J5A53_RS03820	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
J5A53_RS03830	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J5A53_RS03835	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
J5A53_RS03845	COG2226	methyltransferase
J5A53_RS03855	COG4133	protoheme IX ABC transporter activity
J5A53_RS03875	COG1169	isochorismate synthase
J5A53_RS03890	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5A53_RS03895	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5A53_RS03900	COG0649	NAD binding
J5A53_RS03910	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J5A53_RS03915	COG1034	ATP synthesis coupled electron transport
J5A53_RS03920	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
J5A53_RS03925	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5A53_RS03930	COG0839	Belongs to the complex I subunit 6 family
J5A53_RS03935	COG0713	ATP synthesis coupled electron transport
J5A53_RS03950	COG1007	ATP synthesis coupled electron transport
J5A53_RS03955	COG0142	geranyltranstransferase activity
J5A53_RS03975	COG3552	Protein containing von Willebrand factor type A (VWA) domain
J5A53_RS03980	COG0714	Associated with various cellular activities
J5A53_RS04005	COG1013	pyruvate-flavodoxin oxidoreductase activity
J5A53_RS04010	COG0674	pyruvate-flavodoxin oxidoreductase activity
J5A53_RS04010	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
J5A53_RS04025	COG0708	Exodeoxyribonuclease III
J5A53_RS04030	COG2354	Protein conserved in bacteria
J5A53_RS04040	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
J5A53_RS04040	COG4106	trans-aconitate 2-methyltransferase activity
J5A53_RS04045	COG1666	GTP binding
J5A53_RS04060	COG0813	purine-nucleoside phosphorylase activity
J5A53_RS04065	COG2190	(PTS) system
J5A53_RS04065	COG2211	Major facilitator Superfamily
J5A53_RS04070	COG0789	Transcriptional regulator
J5A53_RS04080	COG1022	Amp-dependent synthetase and ligase
J5A53_RS04100	COG0778	Nitroreductase
J5A53_RS04110	COG0577	efflux transmembrane transporter activity
J5A53_RS04110	COG1136	(ABC) transporter
J5A53_RS04125	COG0360	Binds together with S18 to 16S ribosomal RNA
J5A53_RS04135	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J5A53_RS04140	COG0359	binds to the 23S rRNA
J5A53_RS04150	COG0577	efflux transmembrane transporter activity
J5A53_RS04150	COG1136	(ABC) transporter
J5A53_RS04180	COG4585	Histidine kinase
J5A53_RS04200	COG4585	Histidine kinase
J5A53_RS04205	COG2197	response regulator
J5A53_RS04215	COG0737	Belongs to the 5'-nucleotidase family
J5A53_RS04245	COG1131	(ABC) transporter
J5A53_RS04260	COG0371	Dehydrogenase
J5A53_RS04270	COG3732	PTS system glucitol sorbitol-specific
J5A53_RS04285	COG3711	transcriptional antiterminator
J5A53_RS04285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5A53_RS04290	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J5A53_RS04320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J5A53_RS04325	COG2030	dehydratase
J5A53_RS04335	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J5A53_RS04350	COG0250	Participates in transcription elongation, termination and antitermination
J5A53_RS04355	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J5A53_RS04360	COG0081	regulation of translation
J5A53_RS04375	COG0254	rRNA binding
J5A53_RS04380	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J5A53_RS04385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J5A53_RS04400	COG2378	regulation of single-species biofilm formation
J5A53_RS04420	COG1132	(ABC) transporter
J5A53_RS04425	COG1132	(ABC) transporter
J5A53_RS04430	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J5A53_RS04435	COG0222	ribosome binding
J5A53_RS04445	COG0085	RNA polymerase activity
J5A53_RS04450	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J5A53_RS04455	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J5A53_RS04460	COG0049	tRNA binding
J5A53_RS04465	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J5A53_RS04475	COG0698	ribose 5-phosphate isomerase
J5A53_RS04480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J5A53_RS04490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J5A53_RS04500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J5A53_RS04510	COG1136	(ABC) transporter
J5A53_RS04525	COG0051	transcription antitermination factor activity, RNA binding
J5A53_RS04530	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J5A53_RS04535	COG0088	Forms part of the polypeptide exit tunnel
J5A53_RS04540	COG0089	rRNA binding
J5A53_RS04545	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J5A53_RS04550	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J5A53_RS04555	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J5A53_RS04560	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J5A53_RS04565	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J5A53_RS04570	COG0255	Belongs to the universal ribosomal protein uL29 family
J5A53_RS04575	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J5A53_RS04585	COG0784	Response regulator, receiver
J5A53_RS04585	COG2198	Histidine kinase
J5A53_RS04585	COG2205	protein histidine kinase activity
J5A53_RS04600	COG1528	Iron-storage protein
J5A53_RS04665	COG3883	PFAM NLP P60 protein
J5A53_RS04665	COG0791	NLP P60 protein
J5A53_RS04685	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J5A53_RS04690	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J5A53_RS04695	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J5A53_RS04700	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J5A53_RS04705	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J5A53_RS04710	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J5A53_RS04715	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J5A53_RS04720	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J5A53_RS04725	COG1841	ribosomal large subunit assembly
J5A53_RS04735	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
J5A53_RS04740	COG0201	protein transport
J5A53_RS04745	COG0563	adenylate kinase activity
J5A53_RS04750	COG0024	Methionine aminopeptidase
J5A53_RS04765	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J5A53_RS04770	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J5A53_RS04775	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J5A53_RS04780	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J5A53_RS04785	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J5A53_RS04790	COG0202	RNA polymerase activity
J5A53_RS04795	COG0203	ribosomal protein L17
J5A53_RS04820	COG1674	ftsk spoiiie
J5A53_RS04925	COG0444	Belongs to the ABC transporter superfamily
J5A53_RS04930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5A53_RS04935	COG0601	transmembrane transport
J5A53_RS04960	COG0101	tRNA pseudouridine synthase activity
J5A53_RS04965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J5A53_RS04975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A53_RS04980	COG1120	ATPase activity
J5A53_RS04985	COG3304	Inner membrane component domain
J5A53_RS05000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J5A53_RS05000	COG2169	Transcriptional regulator
J5A53_RS05010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J5A53_RS05015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J5A53_RS05020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J5A53_RS05025	COG1072	(Pantothenic acid kinase))
J5A53_RS05030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J5A53_RS05030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
J5A53_RS05035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J5A53_RS05040	COG0736	holo-[acyl-carrier-protein] synthase activity
J5A53_RS05085	COG0513	Belongs to the DEAD box helicase family
J5A53_RS05090	COG0802	atpase or kinase
J5A53_RS05095	COG0456	acetyltransferase
J5A53_RS05095	COG1214	PFAM Peptidase M22, glycoprotease
J5A53_RS05105	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J5A53_RS05115	COG0601	transmembrane transport
J5A53_RS05120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5A53_RS05145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J5A53_RS05150	COG0459	protein refolding
J5A53_RS05160	COG1486	melibiose metabolic process
J5A53_RS05170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J5A53_RS05175	COG2860	membrane
J5A53_RS05185	COG0516	GMP reductase activity
J5A53_RS05205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A53_RS05210	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A53_RS05215	COG1120	ATPase activity
J5A53_RS05225	COG2826	transposase and inactivated derivatives, IS30 family
J5A53_RS05235	COG3226	Transcriptional regulator
J5A53_RS05255	COG0519	Catalyzes the synthesis of GMP from XMP
J5A53_RS05255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J5A53_RS05265	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
J5A53_RS05270	COG1129	ABC transporter
J5A53_RS05290	COG1983	PspC domain protein
J5A53_RS05305	COG2205	protein histidine kinase activity
J5A53_RS05310	COG2197	response regulator
J5A53_RS05320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J5A53_RS05345	COG0535	radical SAM domain protein
J5A53_RS05355	COG0138	bifunctional purine biosynthesis protein purh
J5A53_RS05360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J5A53_RS05370	COG0039	L-malate dehydrogenase activity
J5A53_RS05375	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5A53_RS05380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J5A53_RS05410	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J5A53_RS05415	COG4988	ABC transporter
J5A53_RS05420	COG1132	(ABC) transporter
J5A53_RS05430	COG0010	Belongs to the arginase family
J5A53_RS05475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J5A53_RS05485	COG0088	Forms part of the polypeptide exit tunnel
J5A53_RS05490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J5A53_RS05515	COG2197	response regulator
J5A53_RS05520	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
J5A53_RS05540	COG0515	serine threonine protein kinase
J5A53_RS05540	COG2815	serine threonine protein kinase
J5A53_RS05550	COG4592	Periplasmic binding protein
J5A53_RS05555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A53_RS05560	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A53_RS05565	COG1120	ATPase activity
J5A53_RS05580	COG0142	geranyltranstransferase activity
J5A53_RS05585	COG2826	transposase and inactivated derivatives, IS30 family
J5A53_RS05595	COG3973	AAA domain
J5A53_RS05600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J5A53_RS05600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J5A53_RS05615	COG0477	Major facilitator Superfamily
J5A53_RS05630	COG0667	Aldo Keto reductase
J5A53_RS05640	COG0215	cysteine-tRNA ligase activity
J5A53_RS05645	COG0140	phosphoribosyl-ATP diphosphatase activity
J5A53_RS05650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J5A53_RS05670	COG1120	ATPase activity
J5A53_RS05675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A53_RS05685	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J5A53_RS05690	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J5A53_RS05695	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J5A53_RS05705	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J5A53_RS05710	COG0072	phenylalanine-tRNA ligase activity
J5A53_RS05710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J5A53_RS05720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J5A53_RS05730	COG0495	leucyl-tRNA aminoacylation
J5A53_RS05735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J5A53_RS05740	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
J5A53_RS05745	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J5A53_RS05750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J5A53_RS05760	COG0165	Argininosuccinate lyase
J5A53_RS05775	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J5A53_RS05800	COG0647	UMP catabolic process
J5A53_RS05815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J5A53_RS05820	COG0497	DNA recombination
J5A53_RS05825	COG1335	isochorismatase
J5A53_RS05845	COG0494	nUDIX hydrolase
J5A53_RS05870	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J5A53_RS05885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J5A53_RS05905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J5A53_RS05910	COG0805	protein transport
J5A53_RS05920	COG4581	dead DEAH box helicase
J5A53_RS05925	COG0107	imidazoleglycerol-phosphate synthase activity
J5A53_RS05930	COG0537	adenosine 5'-monophosphoramidase activity
J5A53_RS05935	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J5A53_RS05945	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J5A53_RS05950	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J5A53_RS05955	COG3609	addiction module antidote protein, CC2985 family
J5A53_RS05960	COG2337	Toxic component of a toxin-antitoxin (TA) module
J5A53_RS06030	COG1053	succinate dehydrogenase
J5A53_RS06035	COG0477	Major facilitator Superfamily
J5A53_RS06040	COG1012	belongs to the aldehyde dehydrogenase family
J5A53_RS06050	COG0028	Belongs to the TPP enzyme family
J5A53_RS06060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J5A53_RS06065	COG1309	transcriptional regulator
J5A53_RS06070	COG0710	3-dehydroquinate dehydratase activity
J5A53_RS06080	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
J5A53_RS06095	COG1333	cytochrome c biogenesis protein
J5A53_RS06100	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J5A53_RS06110	COG0129	dihydroxy-acid dehydratase activity
J5A53_RS06135	COG1643	Atp-dependent helicase
J5A53_RS06140	COG1946	Acyl-CoA thioesterase
J5A53_RS06150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J5A53_RS06190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
J5A53_RS06200	COG1615	UPF0182 protein
J5A53_RS06230	COG0714	Associated with various cellular activities
J5A53_RS06235	COG2001	Belongs to the MraZ family
J5A53_RS06240	COG0275	rRNA processing
J5A53_RS06250	COG0768	penicillin binding
J5A53_RS06255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J5A53_RS06260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J5A53_RS06265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J5A53_RS06270	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J5A53_RS06275	COG0772	Belongs to the SEDS family
J5A53_RS06280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J5A53_RS06285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J5A53_RS06300	COG1799	cell septum assembly
J5A53_RS06320	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J5A53_RS06330	COG0469	pyruvate kinase activity
J5A53_RS06345	COG2050	protein possibly involved in aromatic compounds catabolism
J5A53_RS06360	COG0539	negative regulation of cytoplasmic translation
J5A53_RS06365	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J5A53_RS06365	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J5A53_RS06370	COG0509	glycine decarboxylation via glycine cleavage system
J5A53_RS06375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J5A53_RS06385	COG0237	dephospho-CoA kinase activity
J5A53_RS06390	COG0556	nucleotide-excision repair
J5A53_RS06405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J5A53_RS06410	COG2197	response regulator
J5A53_RS06450	COG0277	FAD linked oxidase domain protein
J5A53_RS06460	COG1022	Amp-dependent synthetase and ligase
J5A53_RS06470	COG0583	DNA-binding transcription factor activity
J5A53_RS06485	COG1201	RNA secondary structure unwinding
J5A53_RS06500	COG0477	Major facilitator Superfamily
J5A53_RS06510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J5A53_RS06515	COG0540	Belongs to the ATCase OTCase family
J5A53_RS06525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J5A53_RS06530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J5A53_RS06560	COG0701	Predicted permease
J5A53_RS06595	COG0371	Dehydrogenase
J5A53_RS06600	COG1070	Carbohydrate kinase
J5A53_RS06605	COG0647	UMP catabolic process
J5A53_RS06615	COG0698	ribose 5-phosphate isomerase
J5A53_RS06620	COG1349	DNA-binding transcription factor activity
J5A53_RS06625	COG0586	Pfam SNARE associated Golgi protein
J5A53_RS06650	COG1950	PFAM Membrane protein of
J5A53_RS06670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J5A53_RS06675	COG0544	peptidyl-prolyl cis-trans isomerase activity
J5A53_RS06685	COG0740	serine-type endopeptidase activity
J5A53_RS06690	COG0740	serine-type endopeptidase activity
J5A53_RS06695	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J5A53_RS06700	COG0793	Belongs to the peptidase S41A family
J5A53_RS06700	COG4946	Tricorn protease homolog
J5A53_RS06705	COG0525	valine-tRNA ligase activity
J5A53_RS06720	COG0285	dihydrofolate synthase activity
J5A53_RS06735	COG1530	ribonuclease E activity
J5A53_RS06735	COG1530	ribonuclease E activity
J5A53_RS06740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J5A53_RS06745	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J5A53_RS06750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J5A53_RS06755	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J5A53_RS06760	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J5A53_RS06765	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J5A53_RS06770	COG0799	negative regulation of ribosome biogenesis
J5A53_RS06790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J5A53_RS06820	COG0656	L-ascorbic acid biosynthetic process
J5A53_RS06850	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
J5A53_RS06855	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J5A53_RS06860	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
J5A53_RS06865	COG0181	hydroxymethylbilane synthase activity
J5A53_RS06870	COG0113	porphobilinogen synthase activity
J5A53_RS06875	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J5A53_RS06900	COG2815	serine threonine protein kinase
J5A53_RS06900	COG0515	serine threonine protein kinase
J5A53_RS06945	COG0456	acetyltransferase
J5A53_RS06945	COG1214	PFAM Peptidase M22, glycoprotease
J5A53_RS06955	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
J5A53_RS06960	COG2855	membrane
J5A53_RS06965	COG1760	l-serine dehydratase
J5A53_RS06985	COG1131	(ABC) transporter
J5A53_RS07010	COG2814	Major facilitator Superfamily
J5A53_RS07015	COG0640	Transcriptional regulator
J5A53_RS07065	COG0277	FAD linked oxidase domain protein
J5A53_RS07070	COG2197	response regulator
J5A53_RS07075	COG3851	Histidine kinase
J5A53_RS07105	COG4868	Belongs to the UPF0371 family
J5A53_RS07110	COG0268	Binds directly to 16S ribosomal RNA
J5A53_RS07115	COG0481	GTPase activity
J5A53_RS07130	COG1175	transmembrane transport
J5A53_RS07145	COG2318	DinB family
J5A53_RS07170	COG4221	oxidoreductase activity
J5A53_RS07180	COG1131	(ABC) transporter
J5A53_RS07195	COG0483	inositol monophosphate 1-phosphatase activity
J5A53_RS07205	COG1420	regulation of RNA biosynthetic process
J5A53_RS07210	COG0484	heat shock protein binding
J5A53_RS07225	COG0343	queuine tRNA-ribosyltransferase activity
J5A53_RS07245	COG1609	Transcriptional regulator
J5A53_RS07260	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J5A53_RS07270	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J5A53_RS07275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J5A53_RS07280	COG1408	metallophosphoesterase
J5A53_RS07310	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J5A53_RS07315	COG3281	Trehalose synthase
J5A53_RS07320	COG0366	Alpha amylase catalytic
J5A53_RS07340	COG0482	sulfurtransferase activity
J5A53_RS07365	COG2197	response regulator
J5A53_RS07370	COG4585	Histidine kinase
J5A53_RS07395	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J5A53_RS07400	COG0154	amidase activity
J5A53_RS07405	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J5A53_RS07415	COG1690	Belongs to the RtcB family
J5A53_RS07430	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J5A53_RS07435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J5A53_RS07440	COG0134	indole-3-glycerol-phosphate synthase activity
J5A53_RS07445	COG0133	tryptophan synthase activity
J5A53_RS07450	COG0159	tryptophan synthase activity
J5A53_RS07460	COG0673	inositol 2-dehydrogenase activity
J5A53_RS07465	COG1653	transport
J5A53_RS07480	COG3842	ATPase activity
J5A53_RS07495	COG0577	efflux transmembrane transporter activity
J5A53_RS07495	COG1136	(ABC) transporter
J5A53_RS07500	COG2197	response regulator
J5A53_RS07515	COG0587	DNA-directed DNA polymerase activity
J5A53_RS07525	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J5A53_RS07530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J5A53_RS07535	COG0131	Imidazoleglycerol-phosphate dehydratase
J5A53_RS07540	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J5A53_RS07545	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J5A53_RS07550	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
J5A53_RS07555	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J5A53_RS07575	COG0456	acetyltransferase
J5A53_RS07580	COG0217	transcriptional regulatory protein
J5A53_RS07585	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J5A53_RS07590	COG0632	four-way junction helicase activity
J5A53_RS07595	COG2255	four-way junction helicase activity
J5A53_RS07600	COG1862	Preprotein translocase
J5A53_RS07605	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J5A53_RS07610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J5A53_RS07615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J5A53_RS07625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J5A53_RS07630	COG1196	nuclear chromosome segregation
J5A53_RS07640	COG0124	histidyl-tRNA synthetase
J5A53_RS07645	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J5A53_RS07655	COG2814	Major facilitator Superfamily
J5A53_RS07675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J5A53_RS07680	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J5A53_RS07685	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J5A53_RS07690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J5A53_RS07695	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J5A53_RS07700	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J5A53_RS07705	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J5A53_RS07710	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J5A53_RS07715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J5A53_RS07720	COG0505	Belongs to the CarA family
J5A53_RS07725	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J5A53_RS07730	COG0167	dihydroorotate dehydrogenase activity
J5A53_RS07735	COG0284	orotidine-5'-phosphate decarboxylase activity
J5A53_RS07745	COG0194	GDP metabolic process
J5A53_RS07750	COG1758	RNA polymerase activity
J5A53_RS07755	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J5A53_RS07765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J5A53_RS07775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J5A53_RS07805	COG0646	methionine synthase
J5A53_RS07805	COG1410	methionine synthase
J5A53_RS07810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J5A53_RS07825	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J5A53_RS07835	COG0488	(ABC) transporter
J5A53_RS07840	COG1160	GTP binding
J5A53_RS07850	COG0702	epimerase
J5A53_RS07865	COG1376	ErfK ybiS ycfS ynhG family protein
J5A53_RS07870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J5A53_RS07870	COG2111	Na H antiporter
J5A53_RS07875	COG1006	Multisubunit Na H antiporter MnhC subunit
J5A53_RS07880	COG0651	ATP synthesis coupled electron transport
J5A53_RS07885	COG1863	multisubunit Na H antiporter MnhE subunit
J5A53_RS07890	COG2212	antiporter activity
J5A53_RS07900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J5A53_RS07905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J5A53_RS07905	COG2813	Specifically methylates the guanine in position
J5A53_RS07910	COG0815	Transfers the fatty acyl group on membrane lipoproteins
J5A53_RS07915	COG1216	Glycosyl transferase, family 2
J5A53_RS07920	COG3030	protein affecting phage T7 exclusion by the F plasmid
J5A53_RS07935	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
J5A53_RS07940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J5A53_RS07950	COG1937	Protein conserved in bacteria
J5A53_RS07960	COG4552	Acetyltransferase involved in intracellular survival and related
J5A53_RS07965	COG1472	Belongs to the glycosyl hydrolase 3 family
J5A53_RS07975	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J5A53_RS07985	COG0009	L-threonylcarbamoyladenylate synthase
J5A53_RS08005	COG1295	ribonuclease BN
J5A53_RS08025	COG1716	ATPase activity
J5A53_RS08055	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J5A53_RS08095	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J5A53_RS08110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J5A53_RS08115	COG1113	amino acid transport
J5A53_RS08120	COG0686	Belongs to the AlaDH PNT family
J5A53_RS08125	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J5A53_RS08130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J5A53_RS08135	COG0531	amino acid
J5A53_RS08140	COG0569	domain protein
J5A53_RS08160	COG0756	dUTP diphosphatase activity
J5A53_RS08180	COG1435	thymidine kinase activity
J5A53_RS08205	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J5A53_RS08220	COG0187	DNA topoisomerase II activity
J5A53_RS08240	COG1278	Cold shock
J5A53_RS08255	COG0513	Belongs to the DEAD box helicase family
J5A53_RS08260	COG0180	Tryptophanyl-tRNA synthetase
J5A53_RS08265	COG0613	PHP domain protein
J5A53_RS08285	COG0653	protein targeting
J5A53_RS08290	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
J5A53_RS08300	COG5401	PFAM Sporulation and spore germination
J5A53_RS08305	COG5002	protein histidine kinase activity
J5A53_RS08310	COG0745	RESPONSE REGULATOR receiver
J5A53_RS08315	COG1678	Uncharacterized ACR, COG1678
J5A53_RS08320	COG0366	Alpha amylase catalytic
J5A53_RS08335	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J5A53_RS08350	COG2884	Cell division ATP-binding protein ftsE
J5A53_RS08355	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
J5A53_RS08375	COG0205	6-phosphofructokinase activity
J5A53_RS08385	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
J5A53_RS08390	COG1653	transport
J5A53_RS08405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J5A53_RS08410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J5A53_RS08430	COG2304	oxidoreductase activity
J5A53_RS08435	COG2304	oxidoreductase activity
J5A53_RS08445	COG0714	Associated with various cellular activities
J5A53_RS08530	COG0406	alpha-ribazole phosphatase activity
J5A53_RS08540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J5A53_RS08550	COG2197	response regulator
J5A53_RS08555	COG4585	Histidine kinase
J5A53_RS08565	COG1131	(ABC) transporter
J5A53_RS08570	COG0232	Belongs to the dGTPase family. Type 2 subfamily
J5A53_RS08575	COG2197	response regulator
J5A53_RS08580	COG3851	Histidine kinase
J5A53_RS08585	COG1136	(ABC) transporter
J5A53_RS08605	COG0339	signal peptide processing
J5A53_RS08610	COG1940	carbohydrate kinase activity
J5A53_RS08625	COG1175	transmembrane transport
J5A53_RS08640	COG0803	Belongs to the bacterial solute-binding protein 9 family
J5A53_RS08645	COG1120	ATPase activity
J5A53_RS08660	COG1381	Involved in DNA repair and RecF pathway recombination
J5A53_RS08665	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J5A53_RS08715	COG0596	Alpha beta hydrolase
J5A53_RS08720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J5A53_RS08735	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J5A53_RS08740	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J5A53_RS08745	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J5A53_RS08750	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J5A53_RS08755	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J5A53_RS08760	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J5A53_RS08765	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J5A53_RS08770	COG0356	it plays a direct role in the translocation of protons across the membrane
J5A53_RS08785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J5A53_RS08795	COG2890	protein-(glutamine-N5) methyltransferase activity
J5A53_RS08800	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J5A53_RS08805	COG0254	rRNA binding
J5A53_RS08815	COG0083	homoserine kinase activity
J5A53_RS08820	COG0460	homoserine dehydrogenase
J5A53_RS08855	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5A53_RS08855	COG0567	Dehydrogenase, E1 component
J5A53_RS08860	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
J5A53_RS08880	COG1595	DNA-templated transcription, initiation
J5A53_RS08890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J5A53_RS08895	COG1162	GTPase activity
J5A53_RS08900	COG0483	inositol monophosphate 1-phosphatase activity
J5A53_RS08905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J5A53_RS08920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5A53_RS08930	COG0747	negative chemotaxis
J5A53_RS08940	COG4942	peptidase
J5A53_RS08950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J5A53_RS08955	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J5A53_RS08960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J5A53_RS08970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J5A53_RS08975	COG2017	converts alpha-aldose to the beta-anomer
J5A53_RS08980	COG1418	mRNA catabolic process
J5A53_RS08985	COG2137	regulation of response to DNA damage stimulus
J5A53_RS09010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J5A53_RS09015	COG1674	ftsk spoiiie
J5A53_RS09020	COG3585	molybdate ion transport
J5A53_RS09030	COG1181	Belongs to the D-alanine--D-alanine ligase family
J5A53_RS09045	COG1120	ATPase activity
J5A53_RS09050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A53_RS09065	COG0066	3-isopropylmalate dehydratase activity
J5A53_RS09070	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J5A53_RS09075	COG1414	Transcriptional regulator
J5A53_RS09090	COG1131	(ABC) transporter
J5A53_RS09100	COG2197	response regulator
J5A53_RS09125	COG0179	Fumarylacetoacetate (FAA) hydrolase
J5A53_RS09130	COG0473	3-isopropylmalate dehydrogenase activity
J5A53_RS09145	COG1061	Type III restriction enzyme res subunit
J5A53_RS09150	COG0477	Major facilitator Superfamily
J5A53_RS09155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J5A53_RS09160	COG0440	acetolactate synthase activity
J5A53_RS09170	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J5A53_RS09200	COG0792	nuclease activity
J5A53_RS09210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J5A53_RS09220	COG0335	large ribosomal subunit rRNA binding
J5A53_RS09225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J5A53_RS09230	COG1053	succinate dehydrogenase
J5A53_RS09240	COG0336	Belongs to the RNA methyltransferase TrmD family
J5A53_RS09245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J5A53_RS09250	COG1837	Belongs to the UPF0109 family
J5A53_RS09255	COG0228	four-way junction DNA binding
J5A53_RS09265	COG0616	signal peptide processing
J5A53_RS09280	COG4585	Histidine kinase
J5A53_RS09290	COG2197	response regulator
J5A53_RS09300	COG0640	Transcriptional regulator
J5A53_RS09310	COG1196	nuclear chromosome segregation
J5A53_RS09320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J5A53_RS09325	COG0571	ribonuclease III activity
J5A53_RS09330	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J5A53_RS09340	COG1846	Transcriptional regulator
J5A53_RS09345	COG0003	Pfam Anion-transporting ATPase
J5A53_RS09355	COG0003	Pfam Anion-transporting ATPase
J5A53_RS09365	COG0601	transmembrane transport
J5A53_RS09370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5A53_RS09375	COG4172	Belongs to the ABC transporter superfamily
J5A53_RS09380	COG1124	(ABC) transporter
J5A53_RS09385	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J5A53_RS09400	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J5A53_RS09405	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
J5A53_RS09415	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J5A53_RS09420	COG1185	polyribonucleotide nucleotidyltransferase activity
J5A53_RS09425	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J5A53_RS09435	COG1556	Lactate utilization protein
J5A53_RS09440	COG1139	Iron-sulfur cluster binding protein
J5A53_RS09445	COG0247	lactate metabolic process
J5A53_RS09450	COG1620	l-lactate permease
J5A53_RS09455	COG4106	trans-aconitate 2-methyltransferase activity
J5A53_RS09460	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
J5A53_RS09475	COG4139	cobalamin transport
J5A53_RS09480	COG2186	Transcriptional regulator
J5A53_RS09485	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J5A53_RS09490	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J5A53_RS09495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J5A53_RS09510	COG0195	Participates in both transcription termination and antitermination
J5A53_RS09515	COG0779	Required for maturation of 30S ribosomal subunits
J5A53_RS09525	COG0442	prolyl-tRNA aminoacylation
J5A53_RS09530	COG0456	acetyltransferase
J5A53_RS09535	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J5A53_RS09550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J5A53_RS09550	COG1648	precorrin-2 dehydrogenase activity
J5A53_RS09555	COG1797	cobyrinic acid a,c-diamide synthase activity
J5A53_RS09560	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
J5A53_RS09615	COG0310	cobalt ion transport
J5A53_RS09630	COG0321	lipoyl(octanoyl) transferase activity
J5A53_RS09635	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J5A53_RS09645	COG0488	(ABC) transporter
J5A53_RS09650	COG2188	Transcriptional regulator
J5A53_RS09695	COG1309	transcriptional regulator
J5A53_RS09700	COG1476	TRANSCRIPTIONal
J5A53_RS09710	COG1131	(ABC) transporter
J5A53_RS09715	COG0174	glutamine synthetase
J5A53_RS09720	COG2409	Drug exporters of the RND superfamily
J5A53_RS09730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5A53_RS09730	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5A53_RS09735	COG1063	alcohol dehydrogenase
J5A53_RS09740	COG1349	DNA-binding transcription factor activity
J5A53_RS09750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5A53_RS09755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J5A53_RS09760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J5A53_RS09765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5A53_RS09770	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
J5A53_RS09780	COG0174	glutamine synthetase
J5A53_RS09845	COG0557	exoribonuclease II activity
J5A53_RS09855	COG0006	proline dipeptidase activity
J5A53_RS09890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J5A53_RS09900	COG1595	DNA-templated transcription, initiation
J5A53_RS09905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5A53_RS09920	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
J5A53_RS09925	COG0297	glycogen (starch) synthase activity
J5A53_RS09945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J5A53_RS09950	COG2171	N-acyltransferase activity
J5A53_RS09990	COG0616	signal peptide processing
J5A53_RS10005	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
J5A53_RS10015	COG1342	Belongs to the UPF0251 family
J5A53_RS10050	COG3552	Protein containing von Willebrand factor type A (VWA) domain
J5A53_RS10060	COG0714	Associated with various cellular activities
J5A53_RS10085	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
J5A53_RS10095	COG0584	glycerophosphoryl diester phosphodiesterase
J5A53_RS10110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J5A53_RS10125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J5A53_RS10135	COG1131	(ABC) transporter
J5A53_RS10140	COG0823	Involved in the tonB-independent uptake of proteins
J5A53_RS10140	COG1506	peptidase
J5A53_RS10140	COG4946	Tricorn protease homolog
J5A53_RS10155	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
J5A53_RS10165	COG1079	Belongs to the binding-protein-dependent transport system permease family
J5A53_RS10170	COG4603	Belongs to the binding-protein-dependent transport system permease family
J5A53_RS10175	COG3845	ABC transporter
J5A53_RS10180	COG1744	ABC transporter substrate-binding protein PnrA-like
J5A53_RS10190	COG1253	flavin adenine dinucleotide binding
J5A53_RS10205	COG1492	cobalamin metabolic process
J5A53_RS10210	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
J5A53_RS10215	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
J5A53_RS10225	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
J5A53_RS10230	COG0750	zinc metalloprotease
J5A53_RS10235	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J5A53_RS10240	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J5A53_RS10245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J5A53_RS10250	COG0575	Belongs to the CDS family
J5A53_RS10255	COG0233	cytoplasmic translational termination
J5A53_RS10260	COG0528	UMP kinase activity
J5A53_RS10265	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J5A53_RS10270	COG0052	Belongs to the universal ribosomal protein uS2 family
J5A53_RS10275	COG1196	nuclear chromosome segregation
J5A53_RS10275	COG0739	heme binding
J5A53_RS10275	COG0741	lytic transglycosylase activity
J5A53_RS10280	COG4974	Belongs to the 'phage' integrase family
J5A53_RS10285	COG0242	peptide deformylase activity
J5A53_RS10315	COG0114	fumarate hydratase activity
J5A53_RS10320	COG1119	ATPase activity
J5A53_RS10330	COG1028	Short-chain dehydrogenase reductase Sdr
J5A53_RS10350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J5A53_RS10355	COG0488	(ABC) transporter
J5A53_RS10375	COG2267	carboxylic ester hydrolase activity
J5A53_RS10385	COG0822	iron-sulfur transferase activity
J5A53_RS10390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J5A53_RS10395	COG0396	ATPase activity
J5A53_RS10435	COG0363	glucosamine-6-phosphate deaminase activity
J5A53_RS10460	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J5A53_RS10465	COG0149	triose-phosphate isomerase activity
J5A53_RS10470	COG0126	phosphoglycerate kinase activity
J5A53_RS10475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J5A53_RS10485	COG0391	Required for morphogenesis under gluconeogenic growth conditions
J5A53_RS10490	COG1660	Displays ATPase and GTPase activities
J5A53_RS10500	COG1122	ATPase activity
J5A53_RS10505	COG1268	BioY protein
J5A53_RS10520	COG0322	excinuclease ABC activity
J5A53_RS10530	COG1160	GTP binding
J5A53_RS10550	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
J5A53_RS10585	COG0252	asparaginase activity
J5A53_RS10630	COG1131	(ABC) transporter
J5A53_RS10645	COG1024	Enoyl-CoA hydratase
J5A53_RS10650	COG3425	synthase
J5A53_RS10655	COG0604	alcohol dehydrogenase
J5A53_RS10655	COG3321	synthase
J5A53_RS10660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J5A53_RS10660	COG0300	oxidoreductase activity
J5A53_RS10660	COG3321	synthase
J5A53_RS10660	COG4221	oxidoreductase activity
J5A53_RS10665	COG4221	oxidoreductase activity
J5A53_RS10665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J5A53_RS10665	COG0300	oxidoreductase activity
J5A53_RS10665	COG3321	synthase
J5A53_RS10670	COG0300	oxidoreductase activity
J5A53_RS10670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J5A53_RS10670	COG4221	oxidoreductase activity
J5A53_RS10670	COG3321	synthase
J5A53_RS10675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J5A53_RS10675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5A53_RS10675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J5A53_RS10675	COG1028	Short-chain dehydrogenase reductase Sdr
J5A53_RS10675	COG3321	synthase
J5A53_RS10680	COG4221	oxidoreductase activity
J5A53_RS10680	COG3321	synthase
J5A53_RS10680	COG1028	Short-chain dehydrogenase reductase Sdr
J5A53_RS10680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J5A53_RS10685	COG1024	Enoyl-CoA hydratase
J5A53_RS10690	COG2070	2-Nitropropane dioxygenase
J5A53_RS10690	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J5A53_RS10710	COG3321	synthase
J5A53_RS10715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J5A53_RS10735	COG1073	alpha beta
J5A53_RS10745	COG0189	ligase activity
J5A53_RS10755	COG0189	ligase activity
J5A53_RS10760	COG0246	Mannitol dehydrogenase
J5A53_RS10775	COG0431	NADPH-dependent FMN reductase
J5A53_RS10795	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J5A53_RS10805	COG1053	succinate dehydrogenase
J5A53_RS10835	COG1739	Uncharacterized protein family UPF0029
J5A53_RS10855	COG0259	pyridoxamine-phosphate oxidase activity
J5A53_RS10865	COG1063	alcohol dehydrogenase
J5A53_RS10870	COG0156	8-amino-7-oxononanoate synthase activity
J5A53_RS10890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J5A53_RS10905	COG2425	protein containing a von Willebrand factor type A (vWA) domain
J5A53_RS10910	COG3552	Protein containing von Willebrand factor type A (VWA) domain
J5A53_RS10925	COG0714	Associated with various cellular activities
J5A53_RS10930	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J5A53_RS10935	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J5A53_RS10940	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J5A53_RS10945	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J5A53_RS10985	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J5A53_RS10995	COG2835	tetraacyldisaccharide 4'-kinase activity
J5A53_RS11000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J5A53_RS11060	COG1316	TRANSCRIPTIONal
J5A53_RS11070	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
J5A53_RS11100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J5A53_RS11110	COG0424	maF-like protein
J5A53_RS11155	COG4770	biotin carboxylase activity
J5A53_RS11160	COG1045	serine acetyltransferase
J5A53_RS11185	COG1070	Carbohydrate kinase
J5A53_RS11200	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5A53_RS11210	COG0191	fructose-bisphosphate aldolase activity
J5A53_RS11230	COG1704	LemA family
J5A53_RS11235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J5A53_RS11250	COG2815	serine threonine protein kinase
J5A53_RS11250	COG0515	serine threonine protein kinase
J5A53_RS11275	COG0714	Associated with various cellular activities
J5A53_RS11300	COG0534	Mate efflux family protein
J5A53_RS11305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J5A53_RS11310	COG1113	amino acid transport
J5A53_RS11325	COG5012	cobalamin binding
J5A53_RS11355	COG0542	response to heat
J5A53_RS11360	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
J5A53_RS11365	COG0514	ATP-dependent DNA helicase (RecQ)
J5A53_RS11425	COG1404	Belongs to the peptidase S8 family
J5A53_RS11435	COG0352	thiamine-phosphate diphosphorylase activity
J5A53_RS11435	COG0351	phosphomethylpyrimidine kinase
J5A53_RS11435	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
J5A53_RS11440	COG0351	phosphomethylpyrimidine kinase
J5A53_RS11445	COG0351	phosphomethylpyrimidine kinase
J5A53_RS11445	COG0352	thiamine-phosphate diphosphorylase activity
J5A53_RS11445	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
J5A53_RS11450	COG0574	Belongs to the PEP-utilizing enzyme family
J5A53_RS11450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J5A53_RS11460	COG1404	Belongs to the peptidase S8 family
J5A53_RS11465	COG2190	(PTS) system
J5A53_RS11465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J5A53_RS11465	COG1263	PTS System
J5A53_RS11510	COG3845	ABC transporter
J5A53_RS11515	COG4721	ABC-type cobalt transport system, permease component
J5A53_RS11530	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
J5A53_RS11535	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
J5A53_RS11570	COG1131	(ABC) transporter
J5A53_RS11600	COG0366	Alpha amylase catalytic
J5A53_RS11610	COG2986	histidine ammonia-lyase
J5A53_RS11620	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
J5A53_RS11695	COG0314	molybdopterin synthase activity
J5A53_RS11700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J5A53_RS11740	COG1120	ATPase activity
J5A53_RS11745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A53_RS11795	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5A53_RS11815	COG1609	Transcriptional regulator
J5A53_RS11825	COG0746	molybdenum cofactor guanylyltransferase activity
J5A53_RS11830	COG0315	cyclic pyranopterin monophosphate synthase activity
J5A53_RS11860	COG1140	nitrate reductase beta subunit
J5A53_RS11900	COG1120	ATPase activity
J5A53_RS11905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
J5A53_RS11910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A53_RS11915	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A53_RS11935	COG1304	FMN binding
J5A53_RS11960	COG3048	D-serine ammonia-lyase activity
J5A53_RS11985	COG0604	alcohol dehydrogenase
J5A53_RS11995	COG0156	8-amino-7-oxononanoate synthase activity
J5A53_RS12005	COG0477	Major facilitator Superfamily
J5A53_RS12015	COG1174	glycine betaine transport
J5A53_RS12025	COG0517	IMP dehydrogenase activity
J5A53_RS12025	COG1125	glycine betaine transport
J5A53_RS12045	COG1013	pyruvate-flavodoxin oxidoreductase activity
J5A53_RS12045	COG0674	pyruvate-flavodoxin oxidoreductase activity
J5A53_RS12045	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
J5A53_RS12045	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
J5A53_RS12055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J5A53_RS12060	COG1321	iron dependent repressor
J5A53_RS12075	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
J5A53_RS12090	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
J5A53_RS12125	COG2252	PERMEase
J5A53_RS12135	COG1278	Cold shock
J5A53_RS12140	COG0363	glucosamine-6-phosphate deaminase activity
J5A53_RS12150	COG0494	nUDIX hydrolase
J5A53_RS12155	COG3142	Participates in the control of copper homeostasis
J5A53_RS12170	COG0454	-acetyltransferase
J5A53_RS12195	COG0275	rRNA processing
J5A53_RS12210	COG3842	ATPase activity
J5A53_RS12215	COG0626	cystathionine gamma-synthase activity
J5A53_RS12220	COG1882	Formate acetyltransferase
J5A53_RS12235	COG3541	Predicted nucleotidyltransferase
J5A53_RS12245	COG2226	methyltransferase
J5A53_RS12275	COG2132	Multicopper oxidase
J5A53_RS12280	COG2205	protein histidine kinase activity
J5A53_RS12285	COG0745	RESPONSE REGULATOR receiver
J5A53_RS12300	COG0215	cysteine-tRNA ligase activity
J5A53_RS12310	COG0698	ribose 5-phosphate isomerase
J5A53_RS12315	COG0789	Transcriptional regulator
J5A53_RS12325	COG1132	(ABC) transporter
J5A53_RS12325	COG2375	cellular response to nickel ion
J5A53_RS12335	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J5A53_RS12360	COG2826	transposase and inactivated derivatives, IS30 family
J5A53_RS12385	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J5A53_RS12390	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J5A53_RS12395	COG1329	Transcriptional regulator
J5A53_RS12400	COG0745	RESPONSE REGULATOR receiver
J5A53_RS12405	COG5002	protein histidine kinase activity
J5A53_RS12410	COG0704	Plays a role in the regulation of phosphate uptake
J5A53_RS12415	COG0726	polysaccharide deacetylase
J5A53_RS12420	COG0588	phosphoglycerate mutase activity
J5A53_RS12425	COG0038	chloride channel
J5A53_RS12480	COG4946	Tricorn protease homolog
J5A53_RS12480	COG1506	peptidase
J5A53_RS12480	COG0823	Involved in the tonB-independent uptake of proteins
J5A53_RS12485	COG2755	lipolytic protein G-D-S-L family
J5A53_RS12485	COG0657	acetylesterase activity
J5A53_RS12495	COG1472	Belongs to the glycosyl hydrolase 3 family
J5A53_RS12505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J5A53_RS12510	COG1113	amino acid transport
J5A53_RS12525	COG1063	alcohol dehydrogenase
J5A53_RS12530	COG2376	Dihydroxyacetone kinase
J5A53_RS12545	COG1028	Short-chain dehydrogenase reductase Sdr
J5A53_RS12555	COG0022	dehydrogenase e1 component
J5A53_RS12560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J5A53_RS12565	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5A53_RS12570	COG1349	DNA-binding transcription factor activity
J5A53_RS12625	COG3591	Belongs to the peptidase S1B family
J5A53_RS12630	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J5A53_RS12650	COG1203	CRISPR-associated helicase, Cas3
J5A53_RS12660	COG1468	defense response to virus
J5A53_RS12660	COG1518	maintenance of DNA repeat elements
J5A53_RS12680	COG0765	amino acid transport
J5A53_RS12700	COG4191	Histidine kinase
J5A53_RS12705	COG0745	RESPONSE REGULATOR receiver
J5A53_RS12720	COG0095	Lipoate-protein ligase
J5A53_RS12730	COG2188	Transcriptional regulator
J5A53_RS12735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J5A53_RS12740	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
J5A53_RS12750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J5A53_RS12775	COG3831	ATPase activity
J5A53_RS12780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J5A53_RS12785	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
J5A53_RS12785	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J5A53_RS12810	COG0148	phosphopyruvate hydratase activity
J5A53_RS12820	COG2304	oxidoreductase activity
J5A53_RS12845	COG0193	aminoacyl-tRNA hydrolase activity
J5A53_RS12850	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J5A53_RS12870	COG0583	DNA-binding transcription factor activity
J5A53_RS12880	COG2094	Belongs to the DNA glycosylase MPG family
J5A53_RS12895	COG1131	(ABC) transporter
J5A53_RS12905	COG1136	(ABC) transporter
J5A53_RS12905	COG0577	efflux transmembrane transporter activity
J5A53_RS12910	COG0577	efflux transmembrane transporter activity
J5A53_RS12910	COG1136	(ABC) transporter
J5A53_RS12925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J5A53_RS12930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J5A53_RS12950	COG0519	Catalyzes the synthesis of GMP from XMP
J5A53_RS12965	COG0577	efflux transmembrane transporter activity
J5A53_RS12965	COG1136	(ABC) transporter
J5A53_RS12980	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J5A53_RS12985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J5A53_RS12990	COG0084	hydrolase, TatD family'
J5A53_RS13015	COG2233	PERMEase
J5A53_RS13020	COG0133	tryptophan synthase activity
J5A53_RS13030	COG5002	protein histidine kinase activity
J5A53_RS13040	COG0785	Cytochrome C biogenesis protein
J5A53_RS13040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J5A53_RS13065	COG1309	transcriptional regulator
J5A53_RS13070	COG2814	Major facilitator Superfamily
J5A53_RS13105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J5A53_RS13110	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J5A53_RS13120	COG1331	Highly conserved protein containing a thioredoxin domain
J5A53_RS13135	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J5A53_RS13145	COG4585	Histidine kinase
J5A53_RS13160	COG2161	toxin-antitoxin pair type II binding
J5A53_RS13165	COG4115	mRNA cleavage
J5A53_RS13170	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J5A53_RS13180	COG0427	acetyl-CoA hydrolase
J5A53_RS13190	COG1051	belongs to the nudix hydrolase family
J5A53_RS13200	COG0047	phosphoribosylformylglycinamidine synthase activity
J5A53_RS13205	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J5A53_RS13220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J5A53_RS13230	COG0577	efflux transmembrane transporter activity
J5A53_RS13230	COG1136	(ABC) transporter
J5A53_RS13235	COG4585	Histidine kinase
J5A53_RS13240	COG2197	response regulator
J5A53_RS13245	COG4152	abc transporter atp-binding protein
J5A53_RS13250	COG1668	transmembrane transport
J5A53_RS13270	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J5A53_RS13275	COG0151	Belongs to the GarS family
J5A53_RS13305	COG3189	MarR family transcriptional regulator
J5A53_RS13320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J5A53_RS13325	COG2376	Dihydroxyacetone kinase
J5A53_RS13330	COG1461	Dihydroxyacetone kinase
J5A53_RS13335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J5A53_RS13355	COG1217	gtp-binding protein TYPA
J5A53_RS13375	COG0738	Major facilitator superfamily
J5A53_RS13390	COG0583	DNA-binding transcription factor activity
J5A53_RS13405	COG2326	polyphosphate kinase activity
J5A53_RS13425	COG0354	folic acid binding
J5A53_RS13430	COG3485	protocatechuate 3,4-dioxygenase
J5A53_RS13435	COG1490	D-aminoacyl-tRNA deacylase activity
J5A53_RS13460	COG0745	RESPONSE REGULATOR receiver
J5A53_RS13465	COG0456	acetyltransferase
J5A53_RS13470	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J5A53_RS13475	COG0494	nUDIX hydrolase
J5A53_RS13475	COG0406	alpha-ribazole phosphatase activity
J5A53_RS13490	COG1401	restriction endodeoxyribonuclease activity
J5A53_RS13505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J5A53_RS13520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J5A53_RS13535	COG1028	Short-chain dehydrogenase reductase Sdr
J5A53_RS13545	COG0406	alpha-ribazole phosphatase activity
J5A53_RS13560	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
J5A53_RS13585	COG1082	Xylose isomerase domain protein TIM barrel
J5A53_RS13595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
J5A53_RS13600	COG2826	transposase and inactivated derivatives, IS30 family
J5A53_RS13615	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
J5A53_RS13645	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J5A53_RS13650	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J5A53_RS13655	COG0302	gtp cyclohydrolase
J5A53_RS13665	COG1252	NADH dehydrogenase
J5A53_RS13670	COG1595	DNA-templated transcription, initiation
J5A53_RS13680	COG0406	alpha-ribazole phosphatase activity
J5A53_RS13715	COG1132	(ABC) transporter
J5A53_RS13770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J5A53_RS13770	COG1648	precorrin-2 dehydrogenase activity
J5A53_RS13790	COG1205	dead DEAH box helicase
J5A53_RS13790	COG1111	helicase
J5A53_RS13810	COG2197	response regulator
J5A53_RS13840	COG2226	methyltransferase
J5A53_RS13900	COG0577	efflux transmembrane transporter activity
J5A53_RS13900	COG1136	(ABC) transporter
J5A53_RS13905	COG0577	efflux transmembrane transporter activity
J5A53_RS13905	COG1136	(ABC) transporter
J5A53_RS13910	COG2197	response regulator
J5A53_RS13950	COG0494	nUDIX hydrolase
J5A53_RS14020	COG0561	phosphatase activity
J5A53_RS14025	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J5A53_RS14045	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
J5A53_RS14055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J5A53_RS14065	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5A53_RS14070	COG0022	dehydrogenase e1 component
J5A53_RS14100	COG2205	protein histidine kinase activity
J5A53_RS14130	COG0366	Alpha amylase catalytic
J5A53_RS14160	COG1940	carbohydrate kinase activity
J5A53_RS14165	COG0395	ABC-type sugar transport system, permease component
J5A53_RS14170	COG1175	transmembrane transport
J5A53_RS14180	COG1940	carbohydrate kinase activity
J5A53_RS14185	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
J5A53_RS14190	COG1027	Aspartate ammonia-lyase
J5A53_RS14200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
J5A53_RS14225	COG0300	oxidoreductase activity
J5A53_RS14280	COG1271	oxidase subunit
J5A53_RS14285	COG1294	oxidase, subunit
J5A53_RS14315	COG4988	ABC transporter
J5A53_RS14320	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
J5A53_RS14330	COG1131	(ABC) transporter
J5A53_RS14335	COG4585	Histidine kinase
J5A53_RS14340	COG2197	response regulator
J5A53_RS14360	COG0477	Major facilitator Superfamily
J5A53_RS14365	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J5A53_RS14380	COG1937	Protein conserved in bacteria
J5A53_RS14385	COG0305	Participates in initiation and elongation during chromosome replication
J5A53_RS14395	COG1129	ABC transporter
J5A53_RS14405	COG1122	ATPase activity
J5A53_RS14410	COG1132	(ABC) transporter
J5A53_RS14410	COG2375	cellular response to nickel ion
J5A53_RS14420	COG1309	transcriptional regulator
J5A53_RS14445	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J5A53_RS14465	COG0673	inositol 2-dehydrogenase activity
J5A53_RS14535	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
J5A53_RS14545	COG0673	inositol 2-dehydrogenase activity
J5A53_RS14560	COG1131	(ABC) transporter
J5A53_RS14565	COG1136	(ABC) transporter
J5A53_RS14620	COG1674	ftsk spoiiie
J5A53_RS14655	COG3266	domain, Protein
J5A53_RS14660	COG1404	Belongs to the peptidase S8 family
J5A53_RS14690	COG0745	RESPONSE REGULATOR receiver
J5A53_RS14695	COG5002	protein histidine kinase activity
J5A53_RS14705	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
J5A53_RS14720	COG1132	(ABC) transporter
J5A53_RS14725	COG0438	transferase activity, transferring glycosyl groups
J5A53_RS14740	COG3022	response to hydroperoxide
J5A53_RS14755	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5A53_RS14810	COG1609	Transcriptional regulator
J5A53_RS14815	COG1879	ABC-type sugar transport system periplasmic component
J5A53_RS14820	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5A53_RS14835	COG0673	inositol 2-dehydrogenase activity
J5A53_RS14840	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J5A53_RS14860	COG1902	pentaerythritol trinitrate reductase activity
J5A53_RS14875	COG0456	acetyltransferase
J5A53_RS14900	COG0395	ABC-type sugar transport system, permease component
J5A53_RS14905	COG1175	transmembrane transport
J5A53_RS14945	COG3962	Belongs to the TPP enzyme family
J5A53_RS14950	COG3718	enzyme involved in inositol metabolism
J5A53_RS15015	COG2197	response regulator
J5A53_RS15020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J5A53_RS15025	COG0673	inositol 2-dehydrogenase activity
J5A53_RS15045	COG0667	Aldo Keto reductase
J5A53_RS15055	COG1309	transcriptional regulator
J5A53_RS15085	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J5A53_RS15090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A53_RS15095	COG1120	ATPase activity
J5A53_RS15120	COG1116	anion transmembrane transporter activity
J5A53_RS15125	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J5A53_RS15150	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J5A53_RS15260	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
J5A53_RS15270	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J5A53_RS15275	COG3739	integral membrane protein
J5A53_RS15295	COG0640	Transcriptional regulator
J5A53_RS15300	COG2814	Major facilitator Superfamily
J5A53_RS15330	COG0561	phosphatase activity
J5A53_RS15350	COG0316	Belongs to the HesB IscA family
J5A53_RS15350	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
J5A53_RS15385	COG1309	transcriptional regulator
J5A53_RS15390	COG1131	(ABC) transporter
J5A53_RS15410	COG0667	Aldo Keto reductase
J5A53_RS15420	COG1131	(ABC) transporter
J5A53_RS15445	COG0205	6-phosphofructokinase activity
J5A53_RS15450	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J5A53_RS15525	COG0803	Belongs to the bacterial solute-binding protein 9 family
J5A53_RS15530	COG1121	(ABC) transporter
J5A53_RS15535	COG1108	ABC-type Mn2 Zn2 transport systems permease components