locus-tag	class	description
ARCH_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ARCH_RS00015	COG0592	DNA-directed DNA polymerase activity
ARCH_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ARCH_RS00030	COG0187	DNA topoisomerase II activity
ARCH_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ARCH_RS00080	COG1846	Transcriptional regulator
ARCH_RS00080	COG1940	carbohydrate kinase activity
ARCH_RS00085	COG0786	glutamate:sodium symporter activity
ARCH_RS00105	COG1620	l-lactate permease
ARCH_RS00110	COG0247	lactate metabolic process
ARCH_RS00115	COG1139	Iron-sulfur cluster binding protein
ARCH_RS00120	COG1556	Lactate utilization protein
ARCH_RS00145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ARCH_RS00185	COG1609	Transcriptional regulator
ARCH_RS00205	COG2814	Major facilitator Superfamily
ARCH_RS00215	COG1082	Xylose isomerase domain protein TIM barrel
ARCH_RS00220	COG0673	inositol 2-dehydrogenase activity
ARCH_RS00225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ARCH_RS00235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ARCH_RS00245	COG3718	enzyme involved in inositol metabolism
ARCH_RS00250	COG3962	Belongs to the TPP enzyme family
ARCH_RS00265	COG1940	carbohydrate kinase activity
ARCH_RS00275	COG0601	transmembrane transport
ARCH_RS00280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ARCH_RS00290	COG1940	carbohydrate kinase activity
ARCH_RS00310	COG0584	glycerophosphoryl diester phosphodiesterase
ARCH_RS00350	COG1088	dTDP-glucose 4,6-dehydratase activity
ARCH_RS00395	COG0463	Glycosyl transferase, family 2
ARCH_RS00415	COG1216	Glycosyl transferase, family 2
ARCH_RS00415	COG1442	glycosyl transferase family 8
ARCH_RS00420	COG3475	LICD family
ARCH_RS00425	COG0697	spore germination
ARCH_RS00430	COG4750	Nucleotidyl transferase
ARCH_RS00435	COG0438	transferase activity, transferring glycosyl groups
ARCH_RS00455	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ARCH_RS00460	COG2963	transposase activity
ARCH_RS00485	COG0697	spore germination
ARCH_RS00500	COG0705	Rhomboid family
ARCH_RS00510	COG3764	Sortase (surface protein transpeptidase)
ARCH_RS00520	COG3547	Transposase (IS116 IS110 IS902 family)
ARCH_RS00530	COG0768	penicillin binding
ARCH_RS00545	COG1716	ATPase activity
ARCH_RS00550	COG1131	(ABC) transporter
ARCH_RS00550	COG1716	ATPase activity
ARCH_RS00550	COG0842	Transport permease protein
ARCH_RS00560	COG2860	membrane
ARCH_RS00570	COG0328	RNA-DNA hybrid ribonuclease activity
ARCH_RS00590	COG1854	S-ribosylhomocysteine lyase activity
ARCH_RS00600	COG1780	Probably involved in ribonucleotide reductase function
ARCH_RS00635	COG0765	amino acid transport
ARCH_RS00645	COG1643	Atp-dependent helicase
ARCH_RS00660	COG2188	Transcriptional regulator
ARCH_RS00690	COG0586	Pfam SNARE associated Golgi protein
ARCH_RS00695	COG1950	PFAM Membrane protein of
ARCH_RS00710	COG0710	3-dehydroquinate dehydratase activity
ARCH_RS00715	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ARCH_RS00720	COG0803	Belongs to the bacterial solute-binding protein 9 family
ARCH_RS00725	COG1121	(ABC) transporter
ARCH_RS00730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ARCH_RS00730	COG1321	iron dependent repressor
ARCH_RS00735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ARCH_RS00740	COG1321	iron dependent repressor
ARCH_RS00745	COG0717	Belongs to the dCTP deaminase family
ARCH_RS00750	COG2111	Na H antiporter
ARCH_RS00750	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ARCH_RS00755	COG1006	Multisubunit Na H antiporter MnhC subunit
ARCH_RS00760	COG0651	ATP synthesis coupled electron transport
ARCH_RS00775	COG1320	monovalent cation:proton antiporter activity
ARCH_RS00785	COG1840	ABC-type Fe3 transport system, periplasmic component
ARCH_RS00795	COG3842	ATPase activity
ARCH_RS00805	COG0395	ABC-type sugar transport system, permease component
ARCH_RS00810	COG1175	transmembrane transport
ARCH_RS00815	COG1653	transport
ARCH_RS00825	COG2814	Major facilitator Superfamily
ARCH_RS00840	COG0662	Cupin 2, conserved barrel domain protein
ARCH_RS00845	COG1505	serine-type exopeptidase activity
ARCH_RS00850	COG0443	Heat shock 70 kDa protein
ARCH_RS00855	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ARCH_RS00860	COG0484	heat shock protein binding
ARCH_RS00865	COG0789	Transcriptional regulator
ARCH_RS00870	COG0494	nUDIX hydrolase
ARCH_RS00885	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ARCH_RS00900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ARCH_RS00915	COG1113	amino acid transport
ARCH_RS00920	COG1260	myo-inositol-1-phosphate synthase
ARCH_RS00935	COG0300	oxidoreductase activity
ARCH_RS00945	COG0494	nUDIX hydrolase
ARCH_RS00975	COG0191	fructose-bisphosphate aldolase activity
ARCH_RS00990	COG1175	transmembrane transport
ARCH_RS01015	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ARCH_RS01020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ARCH_RS01025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ARCH_RS01090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ARCH_RS01130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ARCH_RS01135	COG0306	phosphate transporter
ARCH_RS01145	COG1115	amino acid carrier protein
ARCH_RS01160	COG4044	May play a role in the intracellular transport of hydrophobic ligands
ARCH_RS01165	COG0354	folic acid binding
ARCH_RS01170	COG1490	D-aminoacyl-tRNA deacylase activity
ARCH_RS01200	COG3547	Transposase (IS116 IS110 IS902 family)
ARCH_RS01225	COG2056	Na+-H+ antiporter family
ARCH_RS01235	COG0574	Belongs to the PEP-utilizing enzyme family
ARCH_RS01235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ARCH_RS01240	COG2755	lipolytic protein G-D-S-L family
ARCH_RS01240	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ARCH_RS01270	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ARCH_RS01275	COG2027	D-alanyl-D-alanine carboxypeptidase
ARCH_RS01285	COG0037	tRNA processing
ARCH_RS01290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ARCH_RS01295	COG0302	gtp cyclohydrolase
ARCH_RS01305	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ARCH_RS01330	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ARCH_RS01335	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ARCH_RS01340	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ARCH_RS01345	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ARCH_RS01350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ARCH_RS01360	COG0247	lactate metabolic process
ARCH_RS01365	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
ARCH_RS01370	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ARCH_RS01380	COG1194	a g-specific adenine glycosylase
ARCH_RS01390	COG0477	Major facilitator Superfamily
ARCH_RS01395	COG0477	Major facilitator Superfamily
ARCH_RS01415	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ARCH_RS01420	COG0569	domain protein
ARCH_RS01425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ARCH_RS01440	COG0406	alpha-ribazole phosphatase activity
ARCH_RS01460	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ARCH_RS01470	COG4948	Mandelate Racemase Muconate Lactonizing
ARCH_RS01475	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ARCH_RS01485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ARCH_RS01495	COG2226	methyltransferase
ARCH_RS01500	COG0644	oxidoreductase
ARCH_RS01510	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ARCH_RS01515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ARCH_RS01520	COG0649	NAD binding
ARCH_RS01530	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ARCH_RS01535	COG1034	ATP synthesis coupled electron transport
ARCH_RS01540	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ARCH_RS01555	COG0713	ATP synthesis coupled electron transport
ARCH_RS01570	COG1007	ATP synthesis coupled electron transport
ARCH_RS01575	COG0142	geranyltranstransferase activity
ARCH_RS01580	COG0653	protein targeting
ARCH_RS01585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ARCH_RS01595	COG4691	Plasmid stability protein
ARCH_RS01635	COG0419	ATPase involved in DNA repair
ARCH_RS01640	COG0420	3'-5' exonuclease activity
ARCH_RS01670	COG1162	GTPase activity
ARCH_RS01675	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ARCH_RS01695	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ARCH_RS01700	COG0363	glucosamine-6-phosphate deaminase activity
ARCH_RS01705	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ARCH_RS01710	COG1595	DNA-templated transcription, initiation
ARCH_RS01760	COG0567	Dehydrogenase, E1 component
ARCH_RS01760	COG0508	dehydrogenase complex catalyzes the overall conversion of
ARCH_RS01765	COG1253	flavin adenine dinucleotide binding
ARCH_RS01780	COG0584	glycerophosphoryl diester phosphodiesterase
ARCH_RS01790	COG0018	arginyl-trna synthetase
ARCH_RS01810	COG0254	rRNA binding
ARCH_RS01815	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ARCH_RS01825	COG0009	L-threonylcarbamoyladenylate synthase
ARCH_RS01830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ARCH_RS01840	COG0356	it plays a direct role in the translocation of protons across the membrane
ARCH_RS01845	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ARCH_RS01850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ARCH_RS01855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ARCH_RS01860	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ARCH_RS01865	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ARCH_RS01870	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ARCH_RS01875	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ARCH_RS01885	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
ARCH_RS01920	COG0366	Alpha amylase catalytic
ARCH_RS01935	COG1175	transmembrane transport
ARCH_RS01940	COG3833	ABC-type maltose transport systems, permease component
ARCH_RS01945	COG0431	NADPH-dependent FMN reductase
ARCH_RS01950	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ARCH_RS01955	COG3281	Trehalose synthase
ARCH_RS01965	COG0366	Alpha amylase catalytic
ARCH_RS01975	COG0058	SHG alpha-glucan phosphorylase activity
ARCH_RS01980	COG0180	Tryptophanyl-tRNA synthetase
ARCH_RS02010	COG3480	Lon protease (S16) C-terminal proteolytic domain
ARCH_RS02020	COG1615	UPF0182 protein
ARCH_RS02030	COG1131	(ABC) transporter
ARCH_RS02035	COG1725	Transcriptional regulator
ARCH_RS02080	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ARCH_RS02110	COG2197	response regulator
ARCH_RS02120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ARCH_RS02130	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ARCH_RS02135	COG0154	amidase activity
ARCH_RS02140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ARCH_RS02170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ARCH_RS02185	COG2985	domain, Protein
ARCH_RS02185	COG0569	domain protein
ARCH_RS02190	COG1027	Aspartate ammonia-lyase
ARCH_RS02200	COG1882	Formate acetyltransferase
ARCH_RS02215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ARCH_RS02225	COG1609	Transcriptional regulator
ARCH_RS02230	COG1904	glucuronate isomerase
ARCH_RS02235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ARCH_RS02240	COG0800	Aldolase
ARCH_RS02245	COG1312	Catalyzes the dehydration of D-mannonate
ARCH_RS02250	COG0246	Mannitol dehydrogenase
ARCH_RS02270	COG1136	(ABC) transporter
ARCH_RS02270	COG0577	efflux transmembrane transporter activity
ARCH_RS02395	COG1946	Acyl-CoA thioesterase
ARCH_RS02415	COG2116	formate transmembrane transporter activity
ARCH_RS02425	COG3590	peptidase
ARCH_RS02435	COG1045	serine acetyltransferase
ARCH_RS02445	COG1739	Uncharacterized protein family UPF0029
ARCH_RS02465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ARCH_RS02470	COG1121	(ABC) transporter
ARCH_RS02485	COG1966	Carbon starvation protein
ARCH_RS02510	COG1428	Deoxynucleoside kinase
ARCH_RS02525	COG1653	transport
ARCH_RS02535	COG0395	ABC-type sugar transport system, permease component
ARCH_RS02640	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ARCH_RS02660	COG4626	Terminase
ARCH_RS02660	COG1802	Transcriptional regulator
ARCH_RS02670	COG4695	Portal protein
ARCH_RS02680	COG2197	response regulator
ARCH_RS02695	COG2197	response regulator
ARCH_RS02710	COG1136	(ABC) transporter
ARCH_RS02735	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ARCH_RS02745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ARCH_RS02760	COG0544	peptidyl-prolyl cis-trans isomerase activity
ARCH_RS02765	COG0740	serine-type endopeptidase activity
ARCH_RS02770	COG0740	serine-type endopeptidase activity
ARCH_RS02775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ARCH_RS02780	COG1609	Transcriptional regulator
ARCH_RS02785	COG2271	Major facilitator Superfamily
ARCH_RS02790	COG0483	inositol monophosphate 1-phosphatase activity
ARCH_RS02795	COG1022	Amp-dependent synthetase and ligase
ARCH_RS02815	COG1132	(ABC) transporter
ARCH_RS02820	COG1132	(ABC) transporter
ARCH_RS02825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ARCH_RS02830	COG0285	dihydrofolate synthase activity
ARCH_RS02835	COG0105	UTP biosynthetic process
ARCH_RS02840	COG1461	Dihydroxyacetone kinase
ARCH_RS02885	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ARCH_RS02895	COG1837	Belongs to the UPF0109 family
ARCH_RS02900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ARCH_RS02905	COG0336	Belongs to the RNA methyltransferase TrmD family
ARCH_RS02910	COG0335	large ribosomal subunit rRNA binding
ARCH_RS02915	COG0681	Belongs to the peptidase S26 family
ARCH_RS02920	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ARCH_RS02930	COG0792	nuclease activity
ARCH_RS02945	COG4974	Belongs to the 'phage' integrase family
ARCH_RS02950	COG1404	Belongs to the peptidase S8 family
ARCH_RS02965	COG0052	Belongs to the universal ribosomal protein uS2 family
ARCH_RS02970	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ARCH_RS02980	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ARCH_RS02985	COG0644	oxidoreductase
ARCH_RS02995	COG1113	amino acid transport
ARCH_RS03045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ARCH_RS03055	COG0233	cytoplasmic translational termination
ARCH_RS03065	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ARCH_RS03075	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ARCH_RS03080	COG0750	zinc metalloprotease
ARCH_RS03085	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ARCH_RS03095	COG0442	prolyl-tRNA aminoacylation
ARCH_RS03105	COG0779	Required for maturation of 30S ribosomal subunits
ARCH_RS03120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ARCH_RS03125	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ARCH_RS03130	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ARCH_RS03180	COG1136	(ABC) transporter
ARCH_RS03180	COG0577	efflux transmembrane transporter activity
ARCH_RS03210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ARCH_RS03215	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ARCH_RS03225	COG1185	polyribonucleotide nucleotidyltransferase activity
ARCH_RS03245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ARCH_RS03250	COG3842	ATPase activity
ARCH_RS03260	COG1840	ABC-type Fe3 transport system, periplasmic component
ARCH_RS03270	COG5002	protein histidine kinase activity
ARCH_RS03275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ARCH_RS03280	COG1674	ftsk spoiiie
ARCH_RS03290	COG1546	Belongs to the CinA family
ARCH_RS03290	COG1058	Belongs to the CinA family
ARCH_RS03295	COG1396	sequence-specific DNA binding
ARCH_RS03305	COG2137	regulation of response to DNA damage stimulus
ARCH_RS03310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ARCH_RS03315	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ARCH_RS03320	COG1064	alcohol dehydrogenase
ARCH_RS03325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ARCH_RS03335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ARCH_RS03345	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ARCH_RS03350	COG0318	PFAM AMP-dependent synthetase and ligase
ARCH_RS03370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ARCH_RS03380	COG2001	Belongs to the MraZ family
ARCH_RS03385	COG0275	rRNA processing
ARCH_RS03395	COG0768	penicillin binding
ARCH_RS03400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ARCH_RS03410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ARCH_RS03415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ARCH_RS03430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ARCH_RS03440	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ARCH_RS03445	COG1496	oxidoreductase activity
ARCH_RS03450	COG1799	cell septum assembly
ARCH_RS03465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ARCH_RS03495	COG0735	belongs to the Fur family
ARCH_RS03500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ARCH_RS03500	COG1321	iron dependent repressor
ARCH_RS03505	COG1121	(ABC) transporter
ARCH_RS03515	COG0423	glycine-tRNA ligase activity
ARCH_RS03540	COG1879	ABC-type sugar transport system periplasmic component
ARCH_RS03545	COG1129	ABC transporter
ARCH_RS03550	COG4211	Belongs to the binding-protein-dependent transport system permease family
ARCH_RS03560	COG0358	DNA primase activity
ARCH_RS03630	COG0009	L-threonylcarbamoyladenylate synthase
ARCH_RS03650	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ARCH_RS03675	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ARCH_RS03685	COG3022	response to hydroperoxide
ARCH_RS03700	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ARCH_RS03705	COG0174	glutamine synthetase
ARCH_RS03710	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ARCH_RS03720	COG0174	glutamine synthetase
ARCH_RS03735	COG0508	dehydrogenase complex catalyzes the overall conversion of
ARCH_RS03740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ARCH_RS03750	COG1120	ATPase activity
ARCH_RS03755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ARCH_RS03765	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ARCH_RS03770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ARCH_RS03820	COG0205	6-phosphofructokinase activity
ARCH_RS03825	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ARCH_RS03830	COG0515	serine threonine protein kinase
ARCH_RS03830	COG2815	serine threonine protein kinase
ARCH_RS03845	COG0142	geranyltranstransferase activity
ARCH_RS03860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ARCH_RS03865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ARCH_RS03875	COG0187	DNA topoisomerase II activity
ARCH_RS03890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ARCH_RS03905	COG1435	thymidine kinase activity
ARCH_RS03940	COG0569	domain protein
ARCH_RS03965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ARCH_RS03980	COG2963	transposase activity
ARCH_RS03995	COG1136	(ABC) transporter
ARCH_RS04005	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ARCH_RS04010	COG2963	transposase activity
ARCH_RS04025	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ARCH_RS04095	COG0730	response to heat
ARCH_RS04120	COG0803	Belongs to the bacterial solute-binding protein 9 family
ARCH_RS04125	COG1121	(ABC) transporter
ARCH_RS04130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ARCH_RS04135	COG1760	l-serine dehydratase
ARCH_RS04140	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ARCH_RS04145	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ARCH_RS04155	COG0438	transferase activity, transferring glycosyl groups
ARCH_RS04170	COG0494	nUDIX hydrolase
ARCH_RS04175	COG0217	transcriptional regulatory protein
ARCH_RS04180	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ARCH_RS04185	COG0632	four-way junction helicase activity
ARCH_RS04190	COG2255	four-way junction helicase activity
ARCH_RS04200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ARCH_RS04205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ARCH_RS04210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ARCH_RS04215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ARCH_RS04220	COG1196	nuclear chromosome segregation
ARCH_RS04230	COG0124	histidyl-tRNA synthetase
ARCH_RS04255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ARCH_RS04260	COG1376	ErfK ybiS ycfS ynhG family protein
ARCH_RS04265	COG2409	Drug exporters of the RND superfamily
ARCH_RS04275	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ARCH_RS04280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ARCH_RS04285	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ARCH_RS04305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ARCH_RS04320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ARCH_RS04325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ARCH_RS04330	COG0194	GDP metabolic process
ARCH_RS04335	COG0194	GDP metabolic process
ARCH_RS04340	COG1758	RNA polymerase activity
ARCH_RS04350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ARCH_RS04360	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ARCH_RS04370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ARCH_RS04375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ARCH_RS04380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ARCH_RS04440	COG1160	GTP binding
ARCH_RS04445	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ARCH_RS04455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ARCH_RS04470	COG4974	Belongs to the 'phage' integrase family
ARCH_RS04480	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ARCH_RS04485	COG0149	triose-phosphate isomerase activity
ARCH_RS04490	COG0126	phosphoglycerate kinase activity
ARCH_RS04495	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ARCH_RS04500	COG1481	regulation of sporulation
ARCH_RS04510	COG1660	Displays ATPase and GTPase activities
ARCH_RS04535	COG0556	nucleotide-excision repair
ARCH_RS04545	COG0539	negative regulation of cytoplasmic translation
ARCH_RS04575	COG0469	pyruvate kinase activity
ARCH_RS04580	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ARCH_RS04590	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ARCH_RS04600	COG4122	O-methyltransferase activity
ARCH_RS04605	COG1222	aaa ATPase
ARCH_RS04625	COG1968	undecaprenyl-diphosphatase activity
ARCH_RS04630	COG0667	Aldo Keto reductase
ARCH_RS04645	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ARCH_RS04650	COG0222	ribosome binding
ARCH_RS04680	COG0587	DNA-directed DNA polymerase activity
ARCH_RS04685	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ARCH_RS04710	COG1119	ATPase activity
ARCH_RS04715	COG0297	glycogen (starch) synthase activity
ARCH_RS04725	COG0488	(ABC) transporter
ARCH_RS04735	COG2151	metal-sulfur cluster biosynthetic enzyme
ARCH_RS04740	COG0822	iron-sulfur transferase activity
ARCH_RS04745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ARCH_RS04750	COG0396	ATPase activity
ARCH_RS04760	COG0719	Fe-S assembly protein
ARCH_RS04775	COG0494	nUDIX hydrolase
ARCH_RS04780	COG0728	peptidoglycan biosynthetic process
ARCH_RS04820	COG0647	UMP catabolic process
ARCH_RS04845	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ARCH_RS04850	COG3949	Membrane
ARCH_RS04855	COG0778	Nitroreductase
ARCH_RS04865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ARCH_RS04870	COG0300	oxidoreductase activity
ARCH_RS04880	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ARCH_RS04895	COG4608	Belongs to the ABC transporter superfamily
ARCH_RS04900	COG0444	Belongs to the ABC transporter superfamily
ARCH_RS04915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ARCH_RS04920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ARCH_RS04925	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ARCH_RS04950	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ARCH_RS04955	COG1381	Involved in DNA repair and RecF pathway recombination
ARCH_RS04960	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ARCH_RS04970	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ARCH_RS04980	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ARCH_RS04985	COG0484	heat shock protein binding
ARCH_RS04990	COG1420	regulation of RNA biosynthetic process
ARCH_RS05025	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ARCH_RS05030	COG0481	GTPase activity
ARCH_RS05050	COG0268	Binds directly to 16S ribosomal RNA
ARCH_RS05055	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ARCH_RS05060	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ARCH_RS05075	COG1555	photosystem II stabilization
ARCH_RS05075	COG1596	polysaccharide export
ARCH_RS05080	COG0433	COG0433 Predicted ATPase
ARCH_RS05090	COG0495	leucyl-tRNA aminoacylation
ARCH_RS05115	COG0813	purine-nucleoside phosphorylase activity
ARCH_RS05120	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ARCH_RS05125	COG2011	ABC-type metal ion transport system permease component
ARCH_RS05135	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ARCH_RS05145	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ARCH_RS05150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ARCH_RS05155	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ARCH_RS05175	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ARCH_RS05175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ARCH_RS05180	COG0540	Belongs to the ATCase OTCase family
ARCH_RS05185	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ARCH_RS05195	COG0167	dihydroorotate dehydrogenase activity
ARCH_RS05200	COG0543	2 iron, 2 sulfur cluster binding
ARCH_RS05210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ARCH_RS05220	COG1757	Na H antiporter
ARCH_RS05225	COG0254	rRNA binding
ARCH_RS05235	COG0477	Major facilitator Superfamily
ARCH_RS05245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ARCH_RS05250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ARCH_RS05260	COG0659	secondary active sulfate transmembrane transporter activity
ARCH_RS05285	COG3547	Transposase (IS116 IS110 IS902 family)
ARCH_RS05325	COG0732	type I restriction modification DNA specificity domain
ARCH_RS05355	COG2226	methyltransferase
ARCH_RS05385	COG0406	alpha-ribazole phosphatase activity
ARCH_RS05390	COG0799	negative regulation of ribosome biogenesis
ARCH_RS05400	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ARCH_RS05405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ARCH_RS05415	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ARCH_RS05420	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ARCH_RS05425	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ARCH_RS05430	COG1530	ribonuclease E activity
ARCH_RS05435	COG1271	oxidase subunit
ARCH_RS05440	COG1294	oxidase, subunit
ARCH_RS05445	COG4988	ABC transporter
ARCH_RS05450	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ARCH_RS05465	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ARCH_RS05470	COG0571	ribonuclease III activity
ARCH_RS05485	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ARCH_RS05490	COG0742	ribosomal rna small subunit methyltransferase
ARCH_RS05495	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ARCH_RS05500	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ARCH_RS05530	COG1181	Belongs to the D-alanine--D-alanine ligase family
ARCH_RS05535	COG0204	Acyl-transferase
ARCH_RS05540	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ARCH_RS05550	COG0438	transferase activity, transferring glycosyl groups
ARCH_RS05585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ARCH_RS05630	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ARCH_RS05635	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ARCH_RS05640	COG3177	Filamentation induced by cAMP protein fic
ARCH_RS05650	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ARCH_RS05660	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ARCH_RS05685	COG2985	domain, Protein
ARCH_RS05685	COG0569	domain protein
ARCH_RS05690	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ARCH_RS05695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ARCH_RS05695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ARCH_RS05695	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ARCH_RS05700	COG2376	Dihydroxyacetone kinase
ARCH_RS05720	COG3842	ATPase activity
ARCH_RS05725	COG1840	ABC-type Fe3 transport system, periplasmic component
ARCH_RS05730	COG2271	Major facilitator Superfamily
ARCH_RS05740	COG2205	protein histidine kinase activity
ARCH_RS05745	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ARCH_RS05770	COG1595	DNA-templated transcription, initiation
ARCH_RS05775	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ARCH_RS05785	COG1418	mRNA catabolic process
ARCH_RS05790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ARCH_RS05795	COG1121	(ABC) transporter
ARCH_RS05825	COG1131	(ABC) transporter
ARCH_RS05835	COG1126	abc transporter atp-binding protein
ARCH_RS05840	COG0765	amino acid transport
ARCH_RS05845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ARCH_RS05855	COG1114	Component of the transport system for branched-chain amino acids
ARCH_RS05860	COG1114	Component of the transport system for branched-chain amino acids
ARCH_RS05865	COG1114	Component of the transport system for branched-chain amino acids
ARCH_RS05870	COG0519	Catalyzes the synthesis of GMP from XMP
ARCH_RS05875	COG1285	pathogenesis
ARCH_RS05895	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ARCH_RS05920	COG1252	NADH dehydrogenase
ARCH_RS05935	COG0137	argininosuccinate synthase activity
ARCH_RS05940	COG0165	Argininosuccinate lyase
ARCH_RS05950	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ARCH_RS05955	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ARCH_RS05970	COG1132	(ABC) transporter
ARCH_RS05975	COG2375	cellular response to nickel ion
ARCH_RS05975	COG1132	(ABC) transporter
ARCH_RS05980	COG1129	ABC transporter
ARCH_RS06000	COG0789	Transcriptional regulator
ARCH_RS06035	COG2963	transposase activity
ARCH_RS06120	COG0488	(ABC) transporter
ARCH_RS06130	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ARCH_RS06135	COG0739	heme binding
ARCH_RS06140	COG2177	Part of the ABC transporter FtsEX involved in
ARCH_RS06145	COG2884	Cell division ATP-binding protein ftsE
ARCH_RS06150	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ARCH_RS06205	COG2354	Protein conserved in bacteria
ARCH_RS06215	COG0513	Belongs to the DEAD box helicase family
ARCH_RS06220	COG2095	MarC family integral membrane protein
ARCH_RS06230	COG0006	proline dipeptidase activity
ARCH_RS06255	COG0805	protein transport
ARCH_RS06260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ARCH_RS06275	COG0315	cyclic pyranopterin monophosphate synthase activity
ARCH_RS06300	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ARCH_RS06320	COG0437	4 iron, 4 sulfur cluster binding
ARCH_RS06325	COG0243	molybdopterin cofactor binding
ARCH_RS06330	COG1309	transcriptional regulator
ARCH_RS06360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ARCH_RS06385	COG1079	Belongs to the binding-protein-dependent transport system permease family
ARCH_RS06390	COG4603	Belongs to the binding-protein-dependent transport system permease family
ARCH_RS06395	COG3845	ABC transporter
ARCH_RS06400	COG1744	ABC transporter substrate-binding protein PnrA-like
ARCH_RS06420	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ARCH_RS06425	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ARCH_RS06435	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ARCH_RS06435	COG0352	thiamine-phosphate diphosphorylase activity
ARCH_RS06435	COG0351	phosphomethylpyrimidine kinase
ARCH_RS06450	COG0110	maltose O-acetyltransferase activity
ARCH_RS06470	COG3012	SEC-C Motif Domain Protein
ARCH_RS06475	COG0039	L-malate dehydrogenase activity
ARCH_RS06485	COG0166	Belongs to the GPI family
ARCH_RS06495	COG0205	6-phosphofructokinase activity
ARCH_RS06500	COG3250	beta-galactosidase activity
ARCH_RS06515	COG0045	succinate-CoA ligase (ADP-forming) activity
ARCH_RS06535	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ARCH_RS06570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ARCH_RS06570	COG0519	Catalyzes the synthesis of GMP from XMP
ARCH_RS06580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ARCH_RS06605	COG0857	belongs to the CobB CobQ family
ARCH_RS06605	COG0280	phosphate acetyltransferase
ARCH_RS06610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ARCH_RS06625	COG0114	fumarate hydratase activity
ARCH_RS06630	COG0516	GMP reductase activity
ARCH_RS06640	COG3634	alkyl hydroperoxide reductase activity
ARCH_RS06670	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ARCH_RS06680	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ARCH_RS06685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ARCH_RS06690	COG1053	succinate dehydrogenase
ARCH_RS06715	COG0802	atpase or kinase
ARCH_RS06720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ARCH_RS06725	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ARCH_RS06730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ARCH_RS06735	COG1072	(Pantothenic acid kinase))
ARCH_RS06745	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ARCH_RS06750	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ARCH_RS06755	COG0101	tRNA pseudouridine synthase activity
ARCH_RS06765	COG0203	ribosomal protein L17
ARCH_RS06770	COG0202	RNA polymerase activity
ARCH_RS06775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ARCH_RS06780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ARCH_RS06790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ARCH_RS06795	COG0644	oxidoreductase
ARCH_RS06815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ARCH_RS06820	COG2271	Major facilitator Superfamily
ARCH_RS06825	COG2030	dehydratase
ARCH_RS06830	COG0318	PFAM AMP-dependent synthetase and ligase
ARCH_RS06840	COG1960	acyl-CoA dehydrogenase activity
ARCH_RS06855	COG0024	Methionine aminopeptidase
ARCH_RS06860	COG0563	adenylate kinase activity
ARCH_RS06865	COG0201	protein transport
ARCH_RS06870	COG0200	Binds to the 23S rRNA
ARCH_RS06875	COG1841	ribosomal large subunit assembly
ARCH_RS06880	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ARCH_RS06890	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ARCH_RS06895	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ARCH_RS06900	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ARCH_RS06905	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ARCH_RS06910	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ARCH_RS06915	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ARCH_RS06930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ARCH_RS06935	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ARCH_RS06940	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ARCH_RS06945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ARCH_RS06950	COG0089	rRNA binding
ARCH_RS06955	COG0088	Forms part of the polypeptide exit tunnel
ARCH_RS06960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ARCH_RS06965	COG0051	transcription antitermination factor activity, RNA binding
ARCH_RS06970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ARCH_RS06975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ARCH_RS06980	COG0049	tRNA binding
ARCH_RS06985	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ARCH_RS06995	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ARCH_RS07000	COG0085	RNA polymerase activity
ARCH_RS07005	COG0222	ribosome binding
ARCH_RS07010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ARCH_RS07015	COG0572	uridine kinase
ARCH_RS07020	COG0081	regulation of translation
ARCH_RS07025	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ARCH_RS07045	COG0436	Aminotransferase
ARCH_RS07055	COG3547	Transposase (IS116 IS110 IS902 family)
ARCH_RS07065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ARCH_RS07080	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ARCH_RS07100	COG1666	GTP binding
ARCH_RS07110	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ARCH_RS07125	COG5002	protein histidine kinase activity
ARCH_RS07130	COG0745	RESPONSE REGULATOR receiver
ARCH_RS07165	COG1316	TRANSCRIPTIONal
ARCH_RS07170	COG1316	TRANSCRIPTIONal
ARCH_RS07175	COG0642	Histidine kinase
ARCH_RS07180	COG0745	RESPONSE REGULATOR receiver
ARCH_RS07195	COG0424	maF-like protein
ARCH_RS07220	COG1217	gtp-binding protein TYPA
ARCH_RS07230	COG1132	(ABC) transporter
ARCH_RS07235	COG1132	(ABC) transporter
ARCH_RS07260	COG0321	lipoyl(octanoyl) transferase activity
ARCH_RS07265	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ARCH_RS07270	COG0318	PFAM AMP-dependent synthetase and ligase
ARCH_RS07275	COG1362	aminopeptidase activity
ARCH_RS07300	COG0039	L-malate dehydrogenase activity
ARCH_RS07305	COG3971	2-oxopent-4-enoate hydratase activity
ARCH_RS07320	COG2195	Cleaves the N-terminal amino acid of tripeptides
ARCH_RS07330	COG3711	transcriptional antiterminator
ARCH_RS07335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ARCH_RS07340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ARCH_RS07360	COG0431	NADPH-dependent FMN reductase
ARCH_RS07380	COG0783	Belongs to the Dps family
ARCH_RS07395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ARCH_RS07400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ARCH_RS07405	COG1333	cytochrome c biogenesis protein
ARCH_RS07410	COG0785	Cytochrome C biogenesis protein
ARCH_RS07420	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ARCH_RS07430	COG0698	ribose 5-phosphate isomerase
ARCH_RS07435	COG0235	Class ii aldolase
ARCH_RS07450	COG3663	DNA glycosylase
ARCH_RS07470	COG0733	neurotransmitter:sodium symporter activity
ARCH_RS07475	COG1131	(ABC) transporter
ARCH_RS07480	COG3119	arylsulfatase activity
ARCH_RS07490	COG2814	Major facilitator Superfamily
ARCH_RS07495	COG0641	radical SAM
ARCH_RS07515	COG0012	GTP binding
ARCH_RS07520	COG1322	Protein conserved in bacteria
ARCH_RS07540	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ARCH_RS07550	COG1722	exodeoxyribonuclease VII activity
ARCH_RS07555	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ARCH_RS07555	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ARCH_RS07560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ARCH_RS07570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ARCH_RS07575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ARCH_RS07590	COG1131	(ABC) transporter
ARCH_RS07635	COG0148	phosphopyruvate hydratase activity
ARCH_RS07645	COG0193	aminoacyl-tRNA hydrolase activity
ARCH_RS07650	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ARCH_RS07660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ARCH_RS07670	COG1309	transcriptional regulator
ARCH_RS07675	COG4152	abc transporter atp-binding protein
ARCH_RS07680	COG1668	transmembrane transport
ARCH_RS07780	COG0740	serine-type endopeptidase activity
ARCH_RS07785	COG4695	Portal protein
ARCH_RS07790	COG0640	Transcriptional regulator
ARCH_RS07800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ARCH_RS07885	COG2963	transposase activity
ARCH_RS07895	COG3328	transposase activity
ARCH_RS07900	COG1132	(ABC) transporter
ARCH_RS07905	COG2375	cellular response to nickel ion
ARCH_RS07905	COG1132	(ABC) transporter
ARCH_RS07910	COG1122	ATPase activity
ARCH_RS07960	COG0488	(ABC) transporter
ARCH_RS07965	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ARCH_RS07970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ARCH_RS07970	COG1263	PTS System
ARCH_RS07970	COG2190	(PTS) system
ARCH_RS07975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ARCH_RS07975	COG1263	PTS System
ARCH_RS07985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ARCH_RS07995	COG0084	hydrolase, TatD family'
ARCH_RS08000	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ARCH_RS08005	COG1335	isochorismatase
ARCH_RS08010	COG5646	InterPro IPR014922
ARCH_RS08015	COG2409	Drug exporters of the RND superfamily
ARCH_RS08035	COG1131	(ABC) transporter
ARCH_RS08050	COG2197	response regulator
ARCH_RS08055	COG2813	Specifically methylates the guanine in position
ARCH_RS08080	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ARCH_RS08090	COG1970	mechanosensitive ion channel activity
ARCH_RS08105	COG1054	Belongs to the UPF0176 family
ARCH_RS08120	COG1388	LysM domain
ARCH_RS08120	COG0791	NLP P60 protein
ARCH_RS08120	COG3103	Sh3 type 3 domain protein
ARCH_RS08130	COG2252	PERMEase
ARCH_RS08135	COG1482	cell wall glycoprotein biosynthetic process
ARCH_RS08145	COG1278	Cold shock
ARCH_RS08155	COG1842	Phage shock protein A
ARCH_RS08165	COG0745	RESPONSE REGULATOR receiver
ARCH_RS08170	COG2205	protein histidine kinase activity
ARCH_RS08190	COG0459	protein refolding
ARCH_RS08205	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ARCH_RS08215	COG0156	8-amino-7-oxononanoate synthase activity
ARCH_RS08220	COG1063	alcohol dehydrogenase
ARCH_RS08225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ARCH_RS08235	COG1115	amino acid carrier protein
ARCH_RS08255	COG3842	ATPase activity
ARCH_RS08265	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ARCH_RS08290	COG2963	transposase activity
ARCH_RS08310	COG2233	PERMEase
ARCH_RS08325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ARCH_RS08330	COG0215	cysteine-tRNA ligase activity
ARCH_RS08340	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ARCH_RS08345	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ARCH_RS08350	COG1329	Transcriptional regulator
ARCH_RS08355	COG0745	RESPONSE REGULATOR receiver
ARCH_RS08370	COG0588	phosphoglycerate mutase activity
ARCH_RS08380	COG0446	pyridine nucleotide-disulphide oxidoreductase
ARCH_RS08560	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ARCH_RS08565	COG1754	DNA topoisomerase type I activity
ARCH_RS08565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ARCH_RS08570	COG2890	protein-(glutamine-N5) methyltransferase activity
ARCH_RS08585	COG1205	dead DEAH box helicase
ARCH_RS08585	COG1111	helicase
ARCH_RS08635	COG0596	Alpha beta hydrolase
ARCH_RS08650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ARCH_RS08685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ARCH_RS08695	COG0738	Major facilitator superfamily
ARCH_RS08730	COG4868	Belongs to the UPF0371 family
ARCH_RS08735	COG0242	peptide deformylase activity
ARCH_RS08760	COG0590	tRNA wobble adenosine to inosine editing
ARCH_RS08765	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ARCH_RS08780	COG0463	Glycosyl transferase, family 2
ARCH_RS08800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ARCH_RS08885	COG0477	Major facilitator Superfamily
ARCH_RS08890	COG0657	acetylesterase activity
ARCH_RS08900	COG0471	metal ion transport
ARCH_RS08910	COG1470	cell adhesion involved in biofilm formation
ARCH_RS08910	COG0366	Alpha amylase catalytic
ARCH_RS08920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ARCH_RS08925	COG1492	cobalamin metabolic process
ARCH_RS08930	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ARCH_RS08950	COG2963	transposase activity
ARCH_RS08955	COG1643	Atp-dependent helicase
ARCH_RS08970	COG0343	queuine tRNA-ribosyltransferase activity
ARCH_RS08990	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ARCH_RS08990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ARCH_RS09010	COG0305	Participates in initiation and elongation during chromosome replication
ARCH_RS09035	COG0359	binds to the 23S rRNA
ARCH_RS09040	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ARCH_RS09050	COG0360	Binds together with S18 to 16S ribosomal RNA
ARCH_RS09055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ARCH_RS09060	COG0628	permease
ARCH_RS09070	COG0617	tRNA 3'-terminal CCA addition
ARCH_RS09090	COG0492	ferredoxin-NADP+ reductase activity
ARCH_RS09095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ARCH_RS09110	COG0357	Ribosomal RNA small subunit methyltransferase G
ARCH_RS09115	COG3547	Transposase (IS116 IS110 IS902 family)
ARCH_RS09120	COG1847	R3H domain protein
ARCH_RS09125	COG0706	membrane insertase activity
ARCH_RS09130	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ARCH_RS09135	COG0594	ribonuclease P activity
ARCH_RS09140	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ARCH_RS09175	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ARCH_RS09205	COG0791	NLP P60 protein
ARCH_RS09235	COG0739	heme binding
ARCH_RS09265	COG0521	Mo-molybdopterin cofactor biosynthetic process
ARCH_RS09275	COG3547	Transposase (IS116 IS110 IS902 family)
ARCH_RS09280	COG3547	Transposase (IS116 IS110 IS902 family)
ARCH_RS09300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ARCH_RS09305	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ARCH_RS09350	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ARCH_RS09350	COG0237	dephospho-CoA kinase activity
ARCH_RS09400	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ARCH_RS09400	COG2755	lipolytic protein G-D-S-L family
ARCH_RS09450	COG4585	Histidine kinase
ARCH_RS09485	COG0739	heme binding
ARCH_RS09485	COG0741	lytic transglycosylase activity
ARCH_RS09485	COG1196	nuclear chromosome segregation