locus-tag	class	description
HC352_RS00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HC352_RS00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HC352_RS00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HC352_RS00025	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HC352_RS00030	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HC352_RS00055	ENOG4105D6U	Sodium Glutamate Symporter
HC352_RS00065	ENOG4108IG5	Transcriptional regulator
HC352_RS00080	ENOG4105DAA	L-lactate
HC352_RS00085	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HC352_RS00090	ENOG4107QR9	Iron-sulfur cluster binding protein
HC352_RS00095	ENOG41080R8	Conserved Protein
HC352_RS00110	ENOG4105CNN	ABC, transporter
HC352_RS00115	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HC352_RS00120	ENOG4105C2J	ABC transporter
HC352_RS00150	ENOG4105C94	Transporter
HC352_RS00180	ENOG4105ETE	Transcriptional regulator (LacI family
HC352_RS00185	ENOG4105D7K	pfkb domain protein
HC352_RS00190	ENOG4107QKS	N-acylglucosamine 2-epimerase
HC352_RS00215	ENOG4105CK5	oxidoreductase
HC352_RS00220	ENOG4105C54	Major Facilitator superfamily
HC352_RS00230	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
HC352_RS00240	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HC352_RS00250	ENOG4105EDK	PfkB domain protein
HC352_RS00260	ENOG4105DH8	myo-inositol catabolism
HC352_RS00265	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
HC352_RS00270	ENOG4105C26	Dehydrogenase
HC352_RS00280	ENOG4105EVU	fructokinase
HC352_RS00285	ENOG4105DEF	Extracellular solute-binding protein, family 5
HC352_RS00295	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HC352_RS00325	ENOG4107T6V	glycerophosphoryl diester phosphodiesterase
HC352_RS00330	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HC352_RS00335	ENOG4105EY8	ABC transporter
HC352_RS00340	ENOG4105MFV	ABC-2 type transporter
HC352_RS00365	ENOG4108KMV	Glycosyl transferase (Group 1
HC352_RS00370	ENOG4105KPE	licD family
HC352_RS00400	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
HC352_RS00420	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
HC352_RS00425	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
HC352_RS00440	ENOG4105H63	Glycosyl transferase, family 2
HC352_RS00450	ENOG4106MCE	EamA-like transporter family
HC352_RS00475	ENOG4108U4N	(sortase) family
HC352_RS00480	ENOG4105D9P	serine threonine protein kinase
HC352_RS00485	ENOG4105CJN	penicillin-binding protein
HC352_RS00500	ENOG4105HZM	Fha domain containing protein
HC352_RS00505	ENOG4105TV9	FHA Domain-Containing protein
HC352_RS00530	ENOG4105EN6	Membrane
HC352_RS00540	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HC352_RS00555	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
HC352_RS00565	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
HC352_RS00580	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HC352_RS00585	ENOG4107WAU	Protein tyrosine phosphatase
HC352_RS00605	ENOG4108JEH	abc transporter atp-binding protein
HC352_RS00610	ENOG4105E5Q	amino acid AbC transporter
HC352_RS00620	ENOG4105CQ7	ATP-dependent helicase
HC352_RS00645	ENOG4108TZY	GntR Family Transcriptional Regulator
HC352_RS00675	ENOG4107T5V	SNARE associated Golgi
HC352_RS00680	ENOG41082T9	Membrane
HC352_RS00700	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
HC352_RS00705	ENOG4105DSE	periplasmic solute binding protein
HC352_RS00710	ENOG4105DIK	(ABC) transporter
HC352_RS00715	ENOG4107RPQ	ABC transporter
HC352_RS00720	ENOG4107RBD	ABC, transporter
HC352_RS00730	ENOG4105DHP	deoxycytidine triphosphate deaminase
HC352_RS00745	ENOG4105E0C	molybdate abc transporter
HC352_RS00750	ENOG4108UCS	ABC, transporter
HC352_RS00760	ENOG4105DRS	transport system, permease
HC352_RS00770	ENOG4105WEM	extracellular solute-binding protein
HC352_RS00795	ENOG4108VK3	Cupin 2 Conserved Barrel Domain Protein
HC352_RS00805	ENOG4105CFG	Acts as a chaperone (By similarity)
HC352_RS00810	ENOG4108093	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HC352_RS00815	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HC352_RS00820	ENOG4105KNI	merR family transcriptional Regulator
HC352_RS00840	ENOG4108Z66	YbaK ebsC protein
HC352_RS00850	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
HC352_RS00865	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HC352_RS00870	ENOG4105C85	amino acid
HC352_RS00880	ENOG4105CZA	synthase
HC352_RS00885	ENOG4107S1E	Beta-lactamase
HC352_RS00890	ENOG4105CGK	Exodeoxyribonuclease III
HC352_RS00895	ENOG4108IXY	short-chain dehydrogenase reductase
HC352_RS00905	ENOG4105M6F	mutator MutT protein
HC352_RS00945	ENOG4107RCW	fructose-bisphosphate aldolase
HC352_RS00995	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
HC352_RS01000	ENOG4105C8V	SAICAR synthetase
HC352_RS01005	ENOG4107R37	Glutamate dehydrogenase
HC352_RS01065	ENOG4105E0X	reductase
HC352_RS01105	ENOG4105CJ3	phosphate transporter
HC352_RS01115	ENOG4105BZG	amino acid carrier protein
HC352_RS01125	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
HC352_RS01130	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
HC352_RS01135	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HC352_RS01160	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HC352_RS01165	ENOG4105D3Y	Na H antiporter
HC352_RS01170	ENOG4105CGH	5'-nucleotidase
HC352_RS01175	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HC352_RS01180	ENOG4105EXC	Acyl-transferase
HC352_RS01200	ENOG4105K4H	Nlp p60 protein
HC352_RS01205	ENOG4105F0N	pyrophosphate phospho-hydrolase
HC352_RS01220	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HC352_RS01225	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HC352_RS01230	ENOG4105EUJ	GTP cyclohydrolase i
HC352_RS01235	ENOG4105EEI	dihydropteroate synthase
HC352_RS01265	ENOG4107QQT	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HC352_RS01270	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
HC352_RS01275	ENOG4105CRK	lysyL-tRNA synthetase
HC352_RS01280	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HC352_RS01285	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HC352_RS01295	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HC352_RS01300	ENOG4108KJ0	anaerobic glycerol-3-phosphate dehydrogenase, subunit B
HC352_RS01305	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
HC352_RS01310	ENOG4105DKT	Transcriptional regulator
HC352_RS01315	ENOG4105CEN	a g-specific adenine glycosylase
HC352_RS01320	ENOG4108R86	Transcriptional regulator
HC352_RS01325	ENOG4105C57	major facilitator superfamily
HC352_RS01335	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HC352_RS01340	ENOG4107ZYR	domain protein
HC352_RS01345	ENOG4105CZN	Potassium uptake protein
HC352_RS01365	ENOG4108RH7	phosphoglycerate mutase
HC352_RS01385	ENOG4107SIQ	Naphthoate synthase
HC352_RS01390	ENOG4107TCW	O-succinylbenzoate synthase
HC352_RS01395	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HC352_RS01400	ENOG4105C0H	protease
HC352_RS01405	ENOG4105E4F	Isochorismate synthase
HC352_RS01410	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HC352_RS01415	ENOG4105P52	geranylgeranyl reductase
HC352_RS01425	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HC352_RS01430	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HC352_RS01435	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HC352_RS01445	ENOG4107QIZ	NADH dehydrogenase
HC352_RS01450	ENOG4108IEH	NADH dehydrogenase subunit g
HC352_RS01455	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HC352_RS01460	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HC352_RS01465	ENOG4105DF2	NADH dehydrogenase subunit j
HC352_RS01470	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HC352_RS01485	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HC352_RS01495	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HC352_RS01535	ENOG4105EYH	Exonuclease
HC352_RS01540	ENOG4107RH8	nuclease SbcCD subunit D
HC352_RS01560	ENOG4105WEM	extracellular solute-binding protein
HC352_RS01570	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
HC352_RS01575	ENOG4105CK5	oxidoreductase
HC352_RS01580	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HC352_RS01585	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HC352_RS01595	ENOG4105FDP	GntR family transcriptional regulator
HC352_RS01605	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
HC352_RS01610	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HC352_RS01615	ENOG4105CE4	GlcNAc 6-P deacetylase
HC352_RS01620	ENOG4105EMN	RNA polymerase sigma factor
HC352_RS01670	ENOG4105EHG	Permease protein
HC352_RS01675	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
HC352_RS01685	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HC352_RS01690	ENOG4105C37	(CBS) domain
HC352_RS01700	ENOG4105DR5	peptidase
HC352_RS01715	ENOG4105C75	arginyL-tRNA synthetase
HC352_RS01730	ENOG4105VFB	Binds the 23S rRNA (By similarity)
HC352_RS01735	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HC352_RS01740	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HC352_RS01750	ENOG4105ESV	Glycosyl transferase, family 4
HC352_RS01760	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
HC352_RS01765	ENOG4105ZA1	atp synthase
HC352_RS01770	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
HC352_RS01775	ENOG4108T62	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HC352_RS01780	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HC352_RS01785	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HC352_RS01790	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HC352_RS01805	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
HC352_RS01855	ENOG4105D56	permease protein
HC352_RS01860	ENOG4105EG2	ABC transporter, permease
HC352_RS01865	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HC352_RS01870	ENOG41070F3	Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity)
HC352_RS01875	ENOG4105CG3	alpha amylase, catalytic region
HC352_RS01880	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
HC352_RS01895	ENOG4105C31	Tryptophanyl-tRNA synthetase
HC352_RS01900	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HC352_RS01935	ENOG4105WH1	Two component transcriptional regulator luxr family
HC352_RS01945	ENOG4105DQ6	Transposase
HC352_RS01970	ENOG4105BZ1	(ABC) transporter
HC352_RS02010	ENOG41063PX	domain protein
HC352_RS02020	ENOG4105DJZ	UPF0182 protein
HC352_RS02030	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HC352_RS02050	ENOG4105XPP	Protein of unknown function (DUF1275)
HC352_RS02100	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HC352_RS02115	ENOG4105KRM	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
HC352_RS02130	ENOG4105WH1	Two component transcriptional regulator luxr family
HC352_RS02140	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HC352_RS02145	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HC352_RS02150	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HC352_RS02155	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HC352_RS02160	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HC352_RS02190	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HC352_RS02205	ENOG4105D0C	transport protein
HC352_RS02215	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HC352_RS02220	ENOG4105C6N	Formate acetyltransferase
HC352_RS02240	ENOG4105DFA	alanine racemase domain protein
HC352_RS02255	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HC352_RS02290	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HC352_RS02305	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HC352_RS02335	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
HC352_RS02340	ENOG4108M8W	Monooxygenase
HC352_RS02345	ENOG4108QTI	)-transporter
HC352_RS02360	ENOG4105C9K	Endothelin-converting enzyme 1
HC352_RS02370	ENOG4105D7W	serine acetyltransferase
HC352_RS02380	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HC352_RS02400	ENOG4105CC5	ABC transporter
HC352_RS02405	ENOG4105FDK	ABC transporter
HC352_RS02415	ENOG4105DSE	periplasmic solute binding protein
HC352_RS02435	ENOG41088X7	deoxyguanosine kinase
HC352_RS02450	ENOG4105EEQ	Na H antiporter
HC352_RS02460	ENOG4108QIU	Dehydrogenase
HC352_RS02495	ENOG4107QN2	dihydrolipoyl dehydrogenase
HC352_RS02575	ENOG4105CAR	Terminase, large subunit
HC352_RS02610	ENOG4105WH1	Two component transcriptional regulator luxr family
HC352_RS02635	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
HC352_RS02645	ENOG4105KDC	50s ribosomal protein l28
HC352_RS02650	ENOG4105W0E	50S ribosomal protein L33
HC352_RS02670	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HC352_RS02675	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HC352_RS02680	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HC352_RS02695	ENOG4107R49	K07407 alpha-galactosidase EC 3.2.1.22
HC352_RS02705	ENOG4105DRS	transport system, permease
HC352_RS02710	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HC352_RS02720	ENOG4108IQE	Amp-dependent synthetase and ligase
HC352_RS02725	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HC352_RS02730	ENOG4105II7	pyrroline-5-carboxylate reductase
HC352_RS02740	ENOG4105BZ1	(ABC) transporter
HC352_RS02745	ENOG4105BZ1	(ABC) transporter
HC352_RS02750	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HC352_RS02755	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HC352_RS02760	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HC352_RS02765	ENOG4108UTZ	Dihydroxyacetone kinase
HC352_RS02780	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HC352_RS02805	ENOG4105K5M	30s ribosomal protein S16
HC352_RS02810	ENOG41082KU	UPF0109 protein
HC352_RS02815	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HC352_RS02820	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HC352_RS02825	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HC352_RS02830	ENOG4107QYR	Signal peptidase i
HC352_RS02835	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HC352_RS02845	ENOG41080R2	UPF0102 protein
HC352_RS02860	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HC352_RS02870	ENOG4105CE9	30S ribosomal protein S2
HC352_RS02875	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HC352_RS02890	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HC352_RS02910	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HC352_RS02915	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HC352_RS02925	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HC352_RS02935	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HC352_RS02940	ENOG4105DZP	Membrane-associated zinc metalloprotease
HC352_RS02945	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HC352_RS02955	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HC352_RS02965	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HC352_RS02970	ENOG4105CHV	Transcription elongation factor NusA
HC352_RS02980	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HC352_RS02985	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HC352_RS02990	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HC352_RS03015	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HC352_RS03020	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HC352_RS03035	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HC352_RS03040	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HC352_RS03045	ENOG4105C1V	Peptidase, M16
HC352_RS03055	ENOG4105CN5	Metallo-Beta-Lactamase
HC352_RS03060	ENOG4105F9U	Dehydrogenase
HC352_RS03075	ENOG4105CEV	competence damage-inducible protein
HC352_RS03080	ENOG4105WBV	Transcriptional regulator
HC352_RS03090	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HC352_RS03095	ENOG4105KC9	Modulates RecA activity (By similarity)
HC352_RS03100	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HC352_RS03105	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HC352_RS03115	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HC352_RS03125	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HC352_RS03135	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HC352_RS03140	ENOG4105CEY	Amp-dependent synthetase and ligase
HC352_RS03170	ENOG4108V6E	Cell division protein mraZ
HC352_RS03175	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HC352_RS03185	ENOG4105CJN	penicillin-binding protein
HC352_RS03190	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HC352_RS03200	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HC352_RS03205	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HC352_RS03210	ENOG4105CNI	cell division protein FtsW
HC352_RS03215	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HC352_RS03220	ENOG4105DFU	Cell wall formation (By similarity)
HC352_RS03225	ENOG4105ME9	cell division protein FtsQ
HC352_RS03230	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HC352_RS03235	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HC352_RS03240	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
HC352_RS03255	ENOG4107ZIW	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HC352_RS03290	ENOG4105FAV	ABC, transporter
HC352_RS03295	ENOG4105DIK	(ABC) transporter
HC352_RS03300	ENOG4105DSE	periplasmic solute binding protein
HC352_RS03305	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
HC352_RS03325	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HC352_RS03335	ENOG4105C2J	ABC transporter
HC352_RS03340	ENOG4107R2W	ABC transporter, permease
HC352_RS03345	ENOG4105VFE	sira family
HC352_RS03350	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HC352_RS03385	ENOG4105VE1	Phosphatidylcholine synthase
HC352_RS03405	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HC352_RS03425	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
HC352_RS03440	ENOG4108UZX	fmn reductase
HC352_RS03450	ENOG4108YYC	ycei family
HC352_RS03455	ENOG4105EGD	dinuclear metal center protein, YbgI family
HC352_RS03465	ENOG4107XFJ	UPF0246 protein
HC352_RS03485	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HC352_RS03490	ENOG4105C5F	glutamine synthetase
HC352_RS03495	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HC352_RS03505	ENOG4105C5F	glutamine synthetase
HC352_RS03535	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HC352_RS03545	ENOG4107S4Y	M20 DapE family protein YgeY
HC352_RS03560	ENOG410801I	Peptidyl-prolyl cis-trans isomerase
HC352_RS03580	ENOG4107RJF	diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90)
HC352_RS03585	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
HC352_RS03605	ENOG4105EAH	synthase
HC352_RS03620	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HC352_RS03625	ENOG4108JDX	DNA polymerase iii, epsilon subunit
HC352_RS03635	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HC352_RS03650	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HC352_RS03665	ENOG4107W53	thymidine kinase
HC352_RS03700	ENOG4107VEG	TrkA-N domain protein
HC352_RS03710	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HC352_RS03715	ENOG4105E1F	short-chain dehydrogenase reductase
HC352_RS03720	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HC352_RS03725	ENOG4107T2D	Phosphoribosylaminoimidazolesuccinocarboxamide synthase
HC352_RS03740	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HC352_RS03750	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HC352_RS03755	ENOG4105C12	Phosphoribosylglycinamide synthetase
HC352_RS03760	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
HC352_RS03765	ENOG4105CKU	formyltetrahydrofolate synthetase
HC352_RS03770	ENOG4107QM5	aconitate hydratase
HC352_RS03840	ENOG4105HF0	Membrane
HC352_RS03845	ENOG4105EJQ	L-serine dehydratase
HC352_RS03850	ENOG4105C22	threonyL-tRNA synthetase
HC352_RS03865	ENOG4105E2K	Glycosyl transferase (Group 1
HC352_RS03880	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HC352_RS03885	ENOG4105CDY	transcriptional regulatory protein
HC352_RS03890	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HC352_RS03895	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HC352_RS03900	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HC352_RS03910	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HC352_RS03915	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HC352_RS03920	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HC352_RS03925	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HC352_RS03935	ENOG4105C99	atpase involved in dna repair
HC352_RS03945	ENOG4105CUT	histidyl-tRNA synthetase
HC352_RS03950	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HC352_RS03955	ENOG410890F	Dynamin family
HC352_RS03965	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HC352_RS03970	ENOG4105C9M	aspartyl-trna synthetase
HC352_RS03985	ENOG4107R13	MMPL domain protein
HC352_RS03995	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HC352_RS04000	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HC352_RS04005	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HC352_RS04025	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HC352_RS04030	ENOG4105D49	3-dehydroquinate synthase
HC352_RS04035	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HC352_RS04040	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HC352_RS04045	ENOG410803B	Involved in the transcription termination process (By similarity)
HC352_RS04050	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HC352_RS04055	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HC352_RS04060	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HC352_RS04070	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HC352_RS04080	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HC352_RS04090	ENOG4105DJV	ribulose-phosphate 3-epimerase
HC352_RS04095	ENOG4108I05	Binding-protein-dependent transport systems, inner membrane component
HC352_RS04100	ENOG4107XKF	NMT1 THI5 Like Domain Protein
HC352_RS04130	ENOG4105Q70	
HC352_RS04145	ENOG4108UW8	fha domain-containing protein
HC352_RS04165	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HC352_RS04170	ENOG4105CAT	Cytidine monophosphate kinase
HC352_RS04180	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HC352_RS04185	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
HC352_RS04210	ENOG4105CP7	Triose-phosphate isomerase
HC352_RS04215	ENOG4105BZA	Phosphoglycerate kinase
HC352_RS04220	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HC352_RS04225	ENOG4105CIE	May be required for sporulation (By similarity)
HC352_RS04230	ENOG4105CHW	UPF0052 protein
HC352_RS04235	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HC352_RS04240	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HC352_RS04245	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HC352_RS04255	ENOG4105DHU	Bile acid
HC352_RS04265	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HC352_RS04275	ENOG4105F22	Major Facilitator Superfamily
HC352_RS04280	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HC352_RS04290	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HC352_RS04310	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HC352_RS04325	ENOG4105KA0	thioesterase Superfamily protein
HC352_RS04340	ENOG4105CA9	Pyruvate kinase
HC352_RS04345	ENOG4107TBN	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HC352_RS04355	ENOG4105DVV	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)
HC352_RS04360	ENOG4105WFD	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity)
HC352_RS04365	ENOG4105E5F	proteasome
HC352_RS04370	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
HC352_RS04385	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
HC352_RS04390	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HC352_RS04395	ENOG4105CPC	Aldo Keto reductase
HC352_RS04405	ENOG4105E2X	shikimate dehydrogenase
HC352_RS04450	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HC352_RS04475	ENOG4105DKW	ABC transporter
HC352_RS04480	ENOG4107QPH	glycogen) synthase
HC352_RS04485	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HC352_RS04495	ENOG4105C5H	ABC transporter
HC352_RS04500	ENOG4105VG1	fes assembly suf system protein
HC352_RS04505	ENOG4108UNV	SUF system FeS assembly protein, NifU family
HC352_RS04510	ENOG4105C9B	Cysteine desulfurase
HC352_RS04515	ENOG4105C3K	feS assembly ATPase SufC
HC352_RS04525	ENOG4105JRK	feS assembly protein SufD
HC352_RS04565	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HC352_RS04570	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HC352_RS04585	ENOG4105DSU	hydrolase
HC352_RS04630	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HC352_RS04635	ENOG4108K88	Membrane
HC352_RS04640	ENOG4108DBC	nitroreductase
HC352_RS04645	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
HC352_RS04650	ENOG4105C8Y	Acetylornithine aminotransferase
HC352_RS04655	ENOG4108W6C	Dehydrogenase
HC352_RS04660	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HC352_RS04665	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HC352_RS04670	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HC352_RS04675	ENOG4108JQ7	(ABC) transporter
HC352_RS04680	ENOG4105C3U	ABC transporter
HC352_RS04695	ENOG4108RWN	rrna methyltransferase
HC352_RS04700	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HC352_RS04705	ENOG41084BS	50S ribosomal protein L35
HC352_RS04710	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HC352_RS04730	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HC352_RS04735	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
HC352_RS04740	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HC352_RS04750	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HC352_RS04760	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HC352_RS04765	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HC352_RS04770	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
HC352_RS04810	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HC352_RS04815	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HC352_RS04835	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HC352_RS04840	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HC352_RS04845	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HC352_RS04860	ENOG4105KQC	Competence protein
HC352_RS04865	ENOG4105D7A	ATP-binding protein
HC352_RS04875	ENOG4105C8T	Leucyl-tRNA synthetase
HC352_RS04900	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HC352_RS04910	ENOG4108UMI	ABC transporter, permease
HC352_RS04915	ENOG4105D01	(LipO)protein
HC352_RS04920	ENOG4105C26	Dehydrogenase
HC352_RS04925	ENOG4105CK7	Sodium proline symporter
HC352_RS04930	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
HC352_RS04950	ENOG4105CRK	lysyL-tRNA synthetase
HC352_RS04955	ENOG4105CXT	aspartate transcarbamylase
HC352_RS04960	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HC352_RS04965	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
HC352_RS04970	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
HC352_RS04980	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HC352_RS04985	ENOG4105CD3	dihydroorotase
HC352_RS04995	ENOG4107S6Z	Na H antiporter
HC352_RS05000	ENOG4105NRA	50s ribosomal protein l31 type b
HC352_RS05005	ENOG4105F2M	alpha beta hydrolase fold-3 domain protein
HC352_RS05020	ENOG4108680	CrcB-like protein
HC352_RS05025	ENOG41082CG	Protein CrcB homolog
HC352_RS05030	ENOG4105CBD	Diacylglycerol kinase
HC352_RS05050	ENOG4105CHH	sulfate transporter
HC352_RS05090	ENOG4105F9F	transposase
HC352_RS05155	ENOG4105CVJ	phosphoglycerate mutase
HC352_RS05160	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HC352_RS05170	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HC352_RS05175	ENOG41080RH	Thioredoxin
HC352_RS05185	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HC352_RS05190	ENOG4105K46	50S ribosomal protein l27
HC352_RS05195	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HC352_RS05200	ENOG4105C03	ribonuclease
HC352_RS05205	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HC352_RS05210	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HC352_RS05235	ENOG4108JJ9	ABC, transporter
HC352_RS05240	ENOG4108JJ8	(ABC) transporter
HC352_RS05260	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HC352_RS05275	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HC352_RS05280	ENOG4106H78	methyltransferase
HC352_RS05285	ENOG4105CB5	ATP-dependent DNA helicase recG
HC352_RS05290	ENOG4105VB9	50S ribosomal protein l28
HC352_RS05300	ENOG4105CPF	Cell wall formation (By similarity)
HC352_RS05310	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HC352_RS05320	ENOG4105JNK	Glycosyl transferase (Group 1
HC352_RS05325	ENOG4105DGW	oligopeptidase A
HC352_RS05330	ENOG4106KRW	Has sphingomyelinase and hemolytic activity. Thought to act as a virulence factor
HC352_RS05380	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HC352_RS05665	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
HC352_RS05690	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HC352_RS05695	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HC352_RS05705	ENOG4105KVH	Transcriptional regulator
HC352_RS05710	ENOG4107R3N	Filamentation induced by cAMP protein fic
HC352_RS05720	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HC352_RS05730	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HC352_RS05750	ENOG4108426	dNA-binding protein
HC352_RS05755	ENOG4107WGA	YidE YbjL
HC352_RS05760	ENOG4108SEA	Esterase
HC352_RS05765	ENOG4105VDH	Dihydroxyacetone kinase
HC352_RS05770	ENOG4105CMT	Dihydroxyacetone kinase
HC352_RS05775	ENOG4105C02	permease
HC352_RS05780	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
HC352_RS05795	ENOG4105EUB	pirin domain protein
HC352_RS05800	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HC352_RS05805	ENOG4105C4Y	ABC transporter
HC352_RS05810	ENOG4105CXY	transporter
HC352_RS05820	ENOG4108TQ9	Histidine kinase
HC352_RS05830	ENOG4105C7K	acetolactate synthase
HC352_RS05875	ENOG4105K6V	RNA polymerase
HC352_RS05910	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
HC352_RS05925	ENOG4108V7D	UPF0397 protein
HC352_RS05930	ENOG4108JJB	ABC transporter
HC352_RS05950	ENOG4105DIK	(ABC) transporter
HC352_RS05965	ENOG4105W8V	TRANSCRIPTIONAl REGULATOR GntR family
HC352_RS05970	ENOG4105CZV	ABC transporter
HC352_RS05980	ENOG4105CDA	abc transporter atp-binding protein
HC352_RS05985	ENOG4105DRP	amino acid AbC transporter
HC352_RS05990	ENOG4105EAB	amino acid AbC transporter
HC352_RS06000	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
HC352_RS06005	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
HC352_RS06010	ENOG4105KT7	mgtC SapB transporter
HC352_RS06015	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HC352_RS06050	ENOG4105E5D	amino acid
HC352_RS06060	ENOG4105CNT	hydrolase family 2
HC352_RS06070	ENOG4105C83	adenylosuccinate lyase
HC352_RS06075	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HC352_RS06090	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HC352_RS06095	ENOG41071MT	Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane
HC352_RS06100	ENOG4105CNN	ABC, transporter
HC352_RS06120	ENOG4105PGM	cation diffusion facilitator family transporter
HC352_RS06155	ENOG4108JJB	ABC transporter
HC352_RS06170	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HC352_RS06185	ENOG4107QJG	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
HC352_RS06190	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HC352_RS06195	ENOG4105BZU	Histidine kinase
HC352_RS06200	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
HC352_RS06215	ENOG4105VKD	bioY protein
HC352_RS06220	ENOG4105IBS	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HC352_RS06225	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HC352_RS06230	ENOG4105D8K	carboxyl transferase
HC352_RS06240	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HC352_RS06260	ENOG4108TFM	Kinase, PfkB family
HC352_RS06295	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HC352_RS06300	ENOG4105DR5	peptidase
HC352_RS06305	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
HC352_RS06310	ENOG4105CAK	Cell division ATP-binding protein ftsE
HC352_RS06315	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
HC352_RS06375	ENOG4105C1J	atp-dependent rna helicase
HC352_RS06380	ENOG41081FY	multiple antibiotic resistance (MarC)-related
HC352_RS06415	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HC352_RS06420	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HC352_RS06435	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HC352_RS06460	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HC352_RS06480	ENOG4105QAX	Iron-sulfur
HC352_RS06485	ENOG4107QY8	reductase
HC352_RS06505	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HC352_RS06525	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
HC352_RS06530	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HC352_RS06550	ENOG4105UIB	(ABC) transporter
HC352_RS06555	ENOG4108JQ9	ABC transporter
HC352_RS06560	ENOG4105DIH	basic membrane
HC352_RS06565	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
HC352_RS06580	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HC352_RS06585	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HC352_RS06595	ENOG4108UW5	maltose o-acetyltransferase
HC352_RS06600	ENOG4105WH1	Two component transcriptional regulator luxr family
HC352_RS06620	ENOG4105K5B	UPF0225 protein
HC352_RS06625	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HC352_RS06640	ENOG4107QP8	phosphohexose isomerase
HC352_RS06650	ENOG4105CTQ	phosphohexokinase
HC352_RS06675	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HC352_RS06695	ENOG4108Z6Z	Transcriptional regulator
HC352_RS06705	ENOG4105CH6	catalase
HC352_RS06745	ENOG4105CMM	transposase
HC352_RS06775	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HC352_RS06785	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HC352_RS06805	ENOG4105D3G	Pseudouridine synthase
HC352_RS06810	ENOG4105C6K	Malic enzyme
HC352_RS06815	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HC352_RS06830	ENOG4105C9Q	fumarate hydratase class II
HC352_RS06835	ENOG4107QVP	Dehydrogenase
HC352_RS06845	ENOG4108JU3	Alkyl hydroperoxide reductase
HC352_RS06850	ENOG4105D3R	alkyl hydroperoxide reductase
HC352_RS06855	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HC352_RS06865	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HC352_RS06875	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HC352_RS06880	ENOG4105E33	succinate dehydrogenase
HC352_RS06910	ENOG4108097	ATP-binding protein
HC352_RS06915	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HC352_RS06925	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HC352_RS06930	ENOG4105CS9	pantothenic acid kinase
HC352_RS06940	ENOG4108UJD	30S ribosomal protein S9
HC352_RS06945	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HC352_RS06950	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HC352_RS06960	ENOG4108ZT0	50S ribosomal protein l17
HC352_RS06965	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HC352_RS06970	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HC352_RS06975	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HC352_RS06980	ENOG41067V7	50S ribosomal protein L36
HC352_RS06985	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HC352_RS06995	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HC352_RS07000	ENOG4105C10	Electron transfer flavoprotein
HC352_RS07015	ENOG4105C5X	domain protein
HC352_RS07020	ENOG4105C54	Major Facilitator superfamily
HC352_RS07030	ENOG4105CEY	Amp-dependent synthetase and ligase
HC352_RS07035	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
HC352_RS07055	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HC352_RS07060	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HC352_RS07065	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HC352_RS07070	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HC352_RS07075	ENOG410849U	50S ribosomal protein L30
HC352_RS07080	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HC352_RS07090	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HC352_RS07095	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HC352_RS07100	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HC352_RS07105	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HC352_RS07110	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HC352_RS07115	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HC352_RS07120	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HC352_RS07130	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HC352_RS07135	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HC352_RS07140	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HC352_RS07145	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HC352_RS07150	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HC352_RS07155	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HC352_RS07160	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HC352_RS07165	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HC352_RS07170	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HC352_RS07175	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HC352_RS07180	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HC352_RS07185	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HC352_RS07190	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HC352_RS07195	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HC352_RS07200	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HC352_RS07205	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HC352_RS07210	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HC352_RS07215	ENOG4108VZM	50s ribosomal protein L10
HC352_RS07220	ENOG4105DBI	uridine monophosphokinase
HC352_RS07225	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HC352_RS07230	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HC352_RS07265	ENOG4107R4N	Cell wall formation (By similarity)
HC352_RS07290	ENOG4108VPT	UPF0234 protein
HC352_RS07300	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
HC352_RS07310	ENOG4108T3R	lipoprotein lpqB
HC352_RS07315	ENOG4105BZU	Histidine kinase
HC352_RS07320	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HC352_RS07345	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
HC352_RS07360	ENOG4108KGH	TRANSCRIPTIONal
HC352_RS07365	ENOG41065SU	Two-component system sensor kinase
HC352_RS07370	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HC352_RS07385	ENOG4107WR6	Maf-like protein
HC352_RS07395	ENOG4108Z4U	Ferredoxin
HC352_RS07410	ENOG4105CI3	gtp-binding protein typa
HC352_RS07420	ENOG4105BZ1	(ABC) transporter
HC352_RS07425	ENOG4105BZ1	(ABC) transporter
HC352_RS07430	ENOG4105HJK	ABC transporter
HC352_RS07450	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HC352_RS07455	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HC352_RS07465	ENOG4105DFM	M18 family aminopeptidase
HC352_RS07480	ENOG4105E9K	Isocitrate dehydrogenase
HC352_RS07490	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HC352_RS07510	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HC352_RS07525	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HC352_RS07530	ENOG410849S	phosphocarrier protein (HPr)
HC352_RS07550	ENOG4108YYH	Nadph-dependent fmn reductase
HC352_RS07560	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
HC352_RS07615	ENOG4105C8J	)-transporter
HC352_RS07635	ENOG4105C3G	gtp-binding protein
HC352_RS07645	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HC352_RS07650	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HC352_RS07655	ENOG4105YX8	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HC352_RS07660	ENOG4105D7K	pfkb domain protein
HC352_RS07665	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HC352_RS07675	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HC352_RS07680	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HC352_RS07685	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HC352_RS07695	ENOG4105CJ1	ABC, transporter
HC352_RS07710	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HC352_RS07730	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HC352_RS07740	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HC352_RS07750	ENOG4105E0A	ABC, transporter
HC352_RS07755	ENOG4105EHG	Permease protein
HC352_RS07765	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HC352_RS07770	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HC352_RS07780	ENOG41067SE	Tetr family transcriptional regulator
HC352_RS07785	ENOG4108IUX	(ABC) transporter
HC352_RS07790	ENOG4105RHA	ABC transporter, permease
HC352_RS07800	ENOG4105C5H	ABC transporter
HC352_RS07805	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HC352_RS07810	ENOG4105C5Y	PTS System
HC352_RS07820	ENOG4105CID	antiterminator
HC352_RS07825	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HC352_RS07835	ENOG4105F8V	Hydrolase, tatD family
HC352_RS07840	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HC352_RS07845	ENOG4108RWI	nicotinamidase
HC352_RS07870	ENOG4108M15	ABC transporter
HC352_RS07880	ENOG4105BZU	Histidine kinase
HC352_RS07885	ENOG4105WH1	Two component transcriptional regulator luxr family
HC352_RS07890	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HC352_RS07920	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HC352_RS07930	ENOG41080FJ	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HC352_RS07945	ENOG4105C72	UPF0176 protein
HC352_RS07970	ENOG4105C7N	Xanthine uracil vitamin C permease
HC352_RS07975	ENOG4105EIP	mannose-6-phosphate isomerase
HC352_RS07985	ENOG4105VEQ	Cold shock protein
HC352_RS07995	ENOG41087YS	Phage shock protein A
HC352_RS08005	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HC352_RS08010	ENOG4105BZU	Histidine kinase
HC352_RS08015	ENOG4105CEY	Amp-dependent synthetase and ligase
HC352_RS08040	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HC352_RS08055	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HC352_RS08065	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HC352_RS08070	ENOG4105CPQ	Dehydrogenase
HC352_RS08075	ENOG4105CZN	Potassium uptake protein
HC352_RS08120	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HC352_RS08150	ENOG4105C2W	permease
HC352_RS08165	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HC352_RS08170	ENOG4105C8N	cysteinyl-tRNA synthetase
HC352_RS08180	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HC352_RS08185	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HC352_RS08190	ENOG4108VJ1	Transcriptional regulator (CarD family
HC352_RS08195	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HC352_RS08205	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HC352_RS08260	ENOG4105EQW	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
HC352_RS08325	ENOG4105MU5	relaxase mobilization nuclease domain protein
HC352_RS08365	ENOG4105E4C	Lytic transglycosylase catalytic
HC352_RS08415	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HC352_RS08420	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HC352_RS08425	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HC352_RS08440	ENOG4105C1J	atp-dependent rna helicase
HC352_RS08485	ENOG4105D74	hydrolase
HC352_RS08495	ENOG4105IJJ	transcriptional regulator, crp fnr family
HC352_RS08510	ENOG4105BZ4	penicillin-binding protein
HC352_RS08530	ENOG4108RVA	ribokinase
HC352_RS08540	ENOG4105EDR	glucose galactose transporter
HC352_RS08545	ENOG4107RHR	regulatoR
HC352_RS08570	ENOG4105DPH	UPF0371 protein
HC352_RS08595	ENOG4108Z6B	deaminase
HC352_RS08600	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HC352_RS08630	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HC352_RS08635	ENOG410667J	hydrolase
HC352_RS08725	ENOG4105C8P	)-transporter
HC352_RS08775	ENOG4105CQ7	ATP-dependent helicase
HC352_RS08790	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HC352_RS08820	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
HC352_RS08825	ENOG4105CDU	Replicative dna helicase
HC352_RS08830	ENOG4105C3S	Mate efflux family protein
HC352_RS08840	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HC352_RS08845	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HC352_RS08850	ENOG4107YH6	single-stranded DNA-binding protein
HC352_RS08855	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
HC352_RS08860	ENOG4105BZ4	penicillin-binding protein
HC352_RS08865	ENOG4105DSF	transport protein
HC352_RS08895	ENOG4105C3M	thioredoxin reductase
HC352_RS08900	ENOG4107SQD	Transcriptional regulator, GntR family
HC352_RS08915	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HC352_RS08925	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HC352_RS08930	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HC352_RS08935	ENOG4105XH8	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HC352_RS08940	ENOG41084CH	50S ribosomal protein l34