locus-tag	class	description
HC352_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HC352_RS00010	COG0592	DNA-directed DNA polymerase activity
HC352_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HC352_RS00025	COG0187	DNA topoisomerase II activity
HC352_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC352_RS00055	COG0786	glutamate:sodium symporter activity
HC352_RS00065	COG1309	transcriptional regulator
HC352_RS00080	COG1620	l-lactate permease
HC352_RS00085	COG0247	lactate metabolic process
HC352_RS00090	COG1139	Iron-sulfur cluster binding protein
HC352_RS00095	COG1556	Lactate utilization protein
HC352_RS00105	COG1070	Carbohydrate kinase
HC352_RS00110	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC352_RS00115	COG1879	ABC-type sugar transport system periplasmic component
HC352_RS00120	COG1129	ABC transporter
HC352_RS00150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HC352_RS00180	COG1609	Transcriptional regulator
HC352_RS00215	COG0673	inositol 2-dehydrogenase activity
HC352_RS00220	COG2814	Major facilitator Superfamily
HC352_RS00230	COG1082	Xylose isomerase domain protein TIM barrel
HC352_RS00235	COG0673	inositol 2-dehydrogenase activity
HC352_RS00240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HC352_RS00250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC352_RS00260	COG3718	enzyme involved in inositol metabolism
HC352_RS00265	COG3962	Belongs to the TPP enzyme family
HC352_RS00285	COG0747	negative chemotaxis
HC352_RS00290	COG0601	transmembrane transport
HC352_RS00295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC352_RS00325	COG0584	glycerophosphoryl diester phosphodiesterase
HC352_RS00330	COG1088	dTDP-glucose 4,6-dehydratase activity
HC352_RS00365	COG0438	transferase activity, transferring glycosyl groups
HC352_RS00370	COG3475	LICD family
HC352_RS00375	COG4750	Nucleotidyl transferase
HC352_RS00400	COG0438	transferase activity, transferring glycosyl groups
HC352_RS00425	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HC352_RS00450	COG0697	spore germination
HC352_RS00475	COG3764	Sortase (surface protein transpeptidase)
HC352_RS00485	COG0768	penicillin binding
HC352_RS00500	COG1716	ATPase activity
HC352_RS00505	COG1716	ATPase activity
HC352_RS00530	COG2860	membrane
HC352_RS00540	COG0328	RNA-DNA hybrid ribonuclease activity
HC352_RS00555	COG1854	S-ribosylhomocysteine lyase activity
HC352_RS00565	COG1780	Probably involved in ribonucleotide reductase function
HC352_RS00580	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC352_RS00585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC352_RS00610	COG0765	amino acid transport
HC352_RS00620	COG1643	Atp-dependent helicase
HC352_RS00645	COG2188	Transcriptional regulator
HC352_RS00665	COG2608	mercury ion transmembrane transporter activity
HC352_RS00675	COG0586	Pfam SNARE associated Golgi protein
HC352_RS00680	COG1950	PFAM Membrane protein of
HC352_RS00700	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HC352_RS00705	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC352_RS00710	COG1121	(ABC) transporter
HC352_RS00715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC352_RS00720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC352_RS00730	COG0717	Belongs to the dCTP deaminase family
HC352_RS00745	COG4149	molybdate abc transporter
HC352_RS00750	COG3842	ATPase activity
HC352_RS00760	COG0395	ABC-type sugar transport system, permease component
HC352_RS00765	COG1175	transmembrane transport
HC352_RS00770	COG1653	transport
HC352_RS00780	COG2814	Major facilitator Superfamily
HC352_RS00795	COG0662	Cupin 2, conserved barrel domain protein
HC352_RS00800	COG1505	serine-type exopeptidase activity
HC352_RS00805	COG0443	Heat shock 70 kDa protein
HC352_RS00810	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HC352_RS00815	COG0484	heat shock protein binding
HC352_RS00820	COG0789	Transcriptional regulator
HC352_RS00840	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HC352_RS00850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HC352_RS00870	COG1113	amino acid transport
HC352_RS00880	COG1260	myo-inositol-1-phosphate synthase
HC352_RS00895	COG0300	oxidoreductase activity
HC352_RS00905	COG0494	nUDIX hydrolase
HC352_RS00945	COG0191	fructose-bisphosphate aldolase activity
HC352_RS00995	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HC352_RS01000	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HC352_RS01005	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC352_RS01065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HC352_RS01105	COG0306	phosphate transporter
HC352_RS01115	COG1115	amino acid carrier protein
HC352_RS01125	COG4044	May play a role in the intracellular transport of hydrophobic ligands
HC352_RS01135	COG1490	D-aminoacyl-tRNA deacylase activity
HC352_RS01160	COG0133	tryptophan synthase activity
HC352_RS01165	COG2056	Na+-H+ antiporter family
HC352_RS01170	COG0737	Belongs to the 5'-nucleotidase family
HC352_RS01175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC352_RS01175	COG0574	Belongs to the PEP-utilizing enzyme family
HC352_RS01180	COG2755	lipolytic protein G-D-S-L family
HC352_RS01180	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HC352_RS01200	COG1388	LysM domain
HC352_RS01200	COG0791	NLP P60 protein
HC352_RS01205	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HC352_RS01210	COG2027	D-alanyl-D-alanine carboxypeptidase
HC352_RS01220	COG0037	tRNA processing
HC352_RS01225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HC352_RS01230	COG0302	gtp cyclohydrolase
HC352_RS01235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HC352_RS01240	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HC352_RS01265	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HC352_RS01270	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HC352_RS01275	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HC352_RS01280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HC352_RS01285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HC352_RS01295	COG0247	lactate metabolic process
HC352_RS01300	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HC352_RS01305	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HC352_RS01315	COG1194	a g-specific adenine glycosylase
HC352_RS01320	COG1309	transcriptional regulator
HC352_RS01325	COG0477	Major facilitator Superfamily
HC352_RS01335	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HC352_RS01340	COG0569	domain protein
HC352_RS01345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HC352_RS01365	COG0406	alpha-ribazole phosphatase activity
HC352_RS01385	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HC352_RS01390	COG4948	Mandelate Racemase Muconate Lactonizing
HC352_RS01395	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HC352_RS01400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC352_RS01405	COG1169	isochorismate synthase
HC352_RS01410	COG2226	methyltransferase
HC352_RS01415	COG0644	oxidoreductase
HC352_RS01425	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC352_RS01430	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC352_RS01435	COG0649	NAD binding
HC352_RS01445	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HC352_RS01450	COG1034	ATP synthesis coupled electron transport
HC352_RS01455	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HC352_RS01470	COG0713	ATP synthesis coupled electron transport
HC352_RS01485	COG1007	ATP synthesis coupled electron transport
HC352_RS01495	COG0653	protein targeting
HC352_RS01535	COG0419	ATPase involved in DNA repair
HC352_RS01540	COG0420	3'-5' exonuclease activity
HC352_RS01560	COG1653	transport
HC352_RS01565	COG1175	transmembrane transport
HC352_RS01570	COG0395	ABC-type sugar transport system, permease component
HC352_RS01575	COG0673	inositol 2-dehydrogenase activity
HC352_RS01580	COG1162	GTPase activity
HC352_RS01585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HC352_RS01595	COG2188	Transcriptional regulator
HC352_RS01605	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HC352_RS01610	COG0363	glucosamine-6-phosphate deaminase activity
HC352_RS01615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HC352_RS01620	COG1595	DNA-templated transcription, initiation
HC352_RS01670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC352_RS01675	COG1120	ATPase activity
HC352_RS01685	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC352_RS01685	COG0567	Dehydrogenase, E1 component
HC352_RS01690	COG1253	flavin adenine dinucleotide binding
HC352_RS01700	COG0739	heme binding
HC352_RS01715	COG0018	arginyl-trna synthetase
HC352_RS01730	COG0254	rRNA binding
HC352_RS01735	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HC352_RS01740	COG2890	protein-(glutamine-N5) methyltransferase activity
HC352_RS01750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC352_RS01760	COG0356	it plays a direct role in the translocation of protons across the membrane
HC352_RS01765	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HC352_RS01770	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HC352_RS01775	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HC352_RS01780	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HC352_RS01785	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HC352_RS01790	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HC352_RS01805	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HC352_RS01840	COG0366	Alpha amylase catalytic
HC352_RS01855	COG1175	transmembrane transport
HC352_RS01860	COG3833	ABC-type maltose transport systems, permease component
HC352_RS01865	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HC352_RS01870	COG3281	Trehalose synthase
HC352_RS01875	COG0366	Alpha amylase catalytic
HC352_RS01880	COG0366	Alpha amylase catalytic
HC352_RS01890	COG0058	SHG alpha-glucan phosphorylase activity
HC352_RS01895	COG0180	Tryptophanyl-tRNA synthetase
HC352_RS01900	COG1136	(ABC) transporter
HC352_RS01900	COG0577	efflux transmembrane transporter activity
HC352_RS01935	COG2197	response regulator
HC352_RS01945	COG2801	Transposase and inactivated derivatives
HC352_RS01970	COG1132	(ABC) transporter
HC352_RS02010	COG3480	Lon protease (S16) C-terminal proteolytic domain
HC352_RS02020	COG1615	UPF0182 protein
HC352_RS02030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HC352_RS02035	COG2188	Transcriptional regulator
HC352_RS02050	COG3619	membrane
HC352_RS02100	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HC352_RS02130	COG2197	response regulator
HC352_RS02140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HC352_RS02150	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC352_RS02155	COG0154	amidase activity
HC352_RS02160	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC352_RS02190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HC352_RS02205	COG2985	domain, Protein
HC352_RS02205	COG0569	domain protein
HC352_RS02215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC352_RS02220	COG1882	Formate acetyltransferase
HC352_RS02240	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HC352_RS02255	COG1136	(ABC) transporter
HC352_RS02255	COG0577	efflux transmembrane transporter activity
HC352_RS02305	COG1160	GTP binding
HC352_RS02335	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HC352_RS02340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC352_RS02345	COG2116	formate transmembrane transporter activity
HC352_RS02360	COG3590	peptidase
HC352_RS02370	COG1045	serine acetyltransferase
HC352_RS02380	COG1739	Uncharacterized protein family UPF0029
HC352_RS02400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC352_RS02405	COG1121	(ABC) transporter
HC352_RS02435	COG1428	Deoxynucleoside kinase
HC352_RS02465	COG0137	argininosuccinate synthase activity
HC352_RS02470	COG0165	Argininosuccinate lyase
HC352_RS02495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC352_RS02575	COG4626	Terminase
HC352_RS02575	COG1802	Transcriptional regulator
HC352_RS02610	COG2197	response regulator
HC352_RS02620	COG1136	(ABC) transporter
HC352_RS02635	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HC352_RS02645	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HC352_RS02650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HC352_RS02670	COG0544	peptidyl-prolyl cis-trans isomerase activity
HC352_RS02675	COG0740	serine-type endopeptidase activity
HC352_RS02680	COG0740	serine-type endopeptidase activity
HC352_RS02685	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HC352_RS02695	COG3345	alpha-galactosidase
HC352_RS02705	COG0395	ABC-type sugar transport system, permease component
HC352_RS02710	COG1175	transmembrane transport
HC352_RS02720	COG1022	Amp-dependent synthetase and ligase
HC352_RS02730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC352_RS02740	COG1132	(ABC) transporter
HC352_RS02745	COG1132	(ABC) transporter
HC352_RS02755	COG0285	dihydrofolate synthase activity
HC352_RS02760	COG0105	UTP biosynthetic process
HC352_RS02765	COG1461	Dihydroxyacetone kinase
HC352_RS02800	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC352_RS02810	COG1837	Belongs to the UPF0109 family
HC352_RS02815	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HC352_RS02820	COG0336	Belongs to the RNA methyltransferase TrmD family
HC352_RS02825	COG0335	large ribosomal subunit rRNA binding
HC352_RS02830	COG0681	Belongs to the peptidase S26 family
HC352_RS02835	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HC352_RS02845	COG0792	nuclease activity
HC352_RS02860	COG4974	Belongs to the 'phage' integrase family
HC352_RS02870	COG0052	Belongs to the universal ribosomal protein uS2 family
HC352_RS02875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HC352_RS02890	COG0644	oxidoreductase
HC352_RS02915	COG0233	cytoplasmic translational termination
HC352_RS02925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HC352_RS02935	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HC352_RS02940	COG0750	zinc metalloprotease
HC352_RS02945	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HC352_RS02955	COG0442	prolyl-tRNA aminoacylation
HC352_RS02965	COG0779	Required for maturation of 30S ribosomal subunits
HC352_RS02970	COG0195	Participates in both transcription termination and antitermination
HC352_RS02980	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HC352_RS02985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HC352_RS02990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HC352_RS03015	COG0577	efflux transmembrane transporter activity
HC352_RS03015	COG1136	(ABC) transporter
HC352_RS03020	COG0577	efflux transmembrane transporter activity
HC352_RS03020	COG1136	(ABC) transporter
HC352_RS03035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HC352_RS03040	COG1185	polyribonucleotide nucleotidyltransferase activity
HC352_RS03045	COG0612	Peptidase, M16
HC352_RS03055	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HC352_RS03060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC352_RS03065	COG1674	ftsk spoiiie
HC352_RS03075	COG1546	Belongs to the CinA family
HC352_RS03075	COG1058	Belongs to the CinA family
HC352_RS03080	COG1396	sequence-specific DNA binding
HC352_RS03095	COG2137	regulation of response to DNA damage stimulus
HC352_RS03100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HC352_RS03105	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HC352_RS03115	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HC352_RS03125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HC352_RS03135	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HC352_RS03140	COG0318	PFAM AMP-dependent synthetase and ligase
HC352_RS03160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC352_RS03170	COG2001	Belongs to the MraZ family
HC352_RS03175	COG0275	rRNA processing
HC352_RS03185	COG0768	penicillin binding
HC352_RS03190	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HC352_RS03200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC352_RS03205	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HC352_RS03210	COG0772	Belongs to the SEDS family
HC352_RS03220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HC352_RS03230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HC352_RS03240	COG1799	cell septum assembly
HC352_RS03255	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HC352_RS03265	COG2153	protein acetylation
HC352_RS03290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC352_RS03295	COG1121	(ABC) transporter
HC352_RS03300	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC352_RS03305	COG0423	glycine-tRNA ligase activity
HC352_RS03335	COG1129	ABC transporter
HC352_RS03340	COG4211	Belongs to the binding-protein-dependent transport system permease family
HC352_RS03345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC352_RS03345	COG0425	Belongs to the sulfur carrier protein TusA family
HC352_RS03350	COG0358	DNA primase activity
HC352_RS03405	COG0009	L-threonylcarbamoyladenylate synthase
HC352_RS03425	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HC352_RS03450	COG2353	YceI-like domain
HC352_RS03455	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HC352_RS03465	COG3022	response to hydroperoxide
HC352_RS03485	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HC352_RS03490	COG0174	glutamine synthetase
HC352_RS03495	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HC352_RS03520	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC352_RS03525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC352_RS03535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HC352_RS03545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC352_RS03580	COG0205	6-phosphofructokinase activity
HC352_RS03585	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HC352_RS03590	COG0515	serine threonine protein kinase
HC352_RS03590	COG2815	serine threonine protein kinase
HC352_RS03595	COG1705	Flagellar rod assembly protein muramidase FlgJ
HC352_RS03595	COG1388	LysM domain
HC352_RS03605	COG0142	geranyltranstransferase activity
HC352_RS03620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HC352_RS03625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HC352_RS03635	COG0187	DNA topoisomerase II activity
HC352_RS03650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC352_RS03665	COG1435	thymidine kinase activity
HC352_RS03700	COG0569	domain protein
HC352_RS03715	COG0300	oxidoreductase activity
HC352_RS03720	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HC352_RS03730	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HC352_RS03735	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HC352_RS03740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HC352_RS03750	COG0138	bifunctional purine biosynthesis protein purh
HC352_RS03755	COG0151	Belongs to the GarS family
HC352_RS03760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC352_RS03765	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HC352_RS03770	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HC352_RS03840	COG0730	response to heat
HC352_RS03845	COG1760	l-serine dehydratase
HC352_RS03850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HC352_RS03855	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HC352_RS03865	COG0438	transferase activity, transferring glycosyl groups
HC352_RS03880	COG0494	nUDIX hydrolase
HC352_RS03885	COG0217	transcriptional regulatory protein
HC352_RS03890	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HC352_RS03895	COG0632	four-way junction helicase activity
HC352_RS03900	COG2255	four-way junction helicase activity
HC352_RS03910	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC352_RS03915	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC352_RS03920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC352_RS03925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HC352_RS03935	COG1196	nuclear chromosome segregation
HC352_RS03945	COG0124	histidyl-tRNA synthetase
HC352_RS03950	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HC352_RS03955	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HC352_RS03970	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HC352_RS03985	COG2409	Drug exporters of the RND superfamily
HC352_RS03995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HC352_RS04000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HC352_RS04005	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HC352_RS04025	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HC352_RS04035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HC352_RS04040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HC352_RS04045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HC352_RS04050	COG0194	GDP metabolic process
HC352_RS04055	COG0194	GDP metabolic process
HC352_RS04060	COG1758	RNA polymerase activity
HC352_RS04070	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HC352_RS04080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HC352_RS04090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HC352_RS04095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC352_RS04100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC352_RS04145	COG1716	ATPase activity
HC352_RS04165	COG1160	GTP binding
HC352_RS04170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HC352_RS04180	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HC352_RS04205	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HC352_RS04210	COG0149	triose-phosphate isomerase activity
HC352_RS04215	COG0126	phosphoglycerate kinase activity
HC352_RS04220	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC352_RS04225	COG1481	regulation of sporulation
HC352_RS04230	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HC352_RS04235	COG1660	Displays ATPase and GTPase activities
HC352_RS04240	COG0322	excinuclease ABC activity
HC352_RS04265	COG0556	nucleotide-excision repair
HC352_RS04275	COG2814	Major facilitator Superfamily
HC352_RS04280	COG0237	dephospho-CoA kinase activity
HC352_RS04280	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HC352_RS04290	COG0577	efflux transmembrane transporter activity
HC352_RS04290	COG1136	(ABC) transporter
HC352_RS04310	COG0539	negative regulation of cytoplasmic translation
HC352_RS04315	COG2226	methyltransferase
HC352_RS04325	COG2050	protein possibly involved in aromatic compounds catabolism
HC352_RS04340	COG0469	pyruvate kinase activity
HC352_RS04345	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HC352_RS04355	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HC352_RS04365	COG4122	O-methyltransferase activity
HC352_RS04370	COG1222	aaa ATPase
HC352_RS04385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC352_RS04390	COG1968	undecaprenyl-diphosphatase activity
HC352_RS04395	COG0667	Aldo Keto reductase
HC352_RS04405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HC352_RS04450	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HC352_RS04475	COG1119	ATPase activity
HC352_RS04480	COG0297	glycogen (starch) synthase activity
HC352_RS04495	COG0488	(ABC) transporter
HC352_RS04500	COG2151	metal-sulfur cluster biosynthetic enzyme
HC352_RS04505	COG0822	iron-sulfur transferase activity
HC352_RS04510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC352_RS04515	COG0396	ATPase activity
HC352_RS04525	COG0719	Fe-S assembly protein
HC352_RS04565	COG0497	DNA recombination
HC352_RS04570	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HC352_RS04585	COG0647	UMP catabolic process
HC352_RS04630	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HC352_RS04635	COG3949	Membrane
HC352_RS04640	COG0778	Nitroreductase
HC352_RS04645	COG1438	arginine binding
HC352_RS04650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC352_RS04655	COG0300	oxidoreductase activity
HC352_RS04665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HC352_RS04670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC352_RS04675	COG4608	Belongs to the ABC transporter superfamily
HC352_RS04680	COG0444	Belongs to the ABC transporter superfamily
HC352_RS04695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC352_RS04700	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HC352_RS04705	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HC352_RS04710	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HC352_RS04730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HC352_RS04735	COG1381	Involved in DNA repair and RecF pathway recombination
HC352_RS04740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HC352_RS04750	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HC352_RS04760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HC352_RS04765	COG0484	heat shock protein binding
HC352_RS04770	COG1420	regulation of RNA biosynthetic process
HC352_RS04810	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HC352_RS04815	COG0481	GTPase activity
HC352_RS04835	COG0268	Binds directly to 16S ribosomal RNA
HC352_RS04840	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HC352_RS04845	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HC352_RS04860	COG1555	photosystem II stabilization
HC352_RS04860	COG1596	polysaccharide export
HC352_RS04865	COG0433	COG0433 Predicted ATPase
HC352_RS04875	COG0495	leucyl-tRNA aminoacylation
HC352_RS04900	COG0813	purine-nucleoside phosphorylase activity
HC352_RS04910	COG2011	ABC-type metal ion transport system permease component
HC352_RS04920	COG1012	belongs to the aldehyde dehydrogenase family
HC352_RS04925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC352_RS04930	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HC352_RS04950	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HC352_RS04950	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HC352_RS04960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HC352_RS04965	COG0284	orotidine-5'-phosphate decarboxylase activity
HC352_RS04970	COG0167	dihydroorotate dehydrogenase activity
HC352_RS04980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HC352_RS04985	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HC352_RS04995	COG1757	Na H antiporter
HC352_RS05000	COG0254	rRNA binding
HC352_RS05020	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC352_RS05025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC352_RS05030	COG1597	lipid kinase activity
HC352_RS05050	COG0659	secondary active sulfate transmembrane transporter activity
HC352_RS05090	COG2826	transposase and inactivated derivatives, IS30 family
HC352_RS05155	COG0406	alpha-ribazole phosphatase activity
HC352_RS05160	COG0799	negative regulation of ribosome biogenesis
HC352_RS05170	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HC352_RS05175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC352_RS05185	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HC352_RS05190	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HC352_RS05195	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HC352_RS05200	COG1530	ribonuclease E activity
HC352_RS05205	COG1271	oxidase subunit
HC352_RS05210	COG1294	oxidase, subunit
HC352_RS05235	COG4988	ABC transporter
HC352_RS05240	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HC352_RS05260	COG0571	ribonuclease III activity
HC352_RS05275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HC352_RS05280	COG0742	ribosomal rna small subunit methyltransferase
HC352_RS05285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HC352_RS05290	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HC352_RS05300	COG1181	Belongs to the D-alanine--D-alanine ligase family
HC352_RS05310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC352_RS05320	COG0438	transferase activity, transferring glycosyl groups
HC352_RS05325	COG0339	signal peptide processing
HC352_RS05380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HC352_RS05665	COG0582	viral genome integration into host DNA
HC352_RS05690	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HC352_RS05695	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HC352_RS05705	COG1733	regulation of RNA biosynthetic process
HC352_RS05720	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HC352_RS05730	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HC352_RS05755	COG0569	domain protein
HC352_RS05755	COG2985	domain, Protein
HC352_RS05760	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HC352_RS05765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC352_RS05765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC352_RS05765	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HC352_RS05770	COG2376	Dihydroxyacetone kinase
HC352_RS05775	COG0628	permease
HC352_RS05805	COG1840	ABC-type Fe3 transport system, periplasmic component
HC352_RS05810	COG2271	Major facilitator Superfamily
HC352_RS05820	COG2205	protein histidine kinase activity
HC352_RS05830	COG0028	Belongs to the TPP enzyme family
HC352_RS05875	COG1595	DNA-templated transcription, initiation
HC352_RS05910	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HC352_RS05925	COG4720	Psort location CytoplasmicMembrane, score
HC352_RS05930	COG1122	ATPase activity
HC352_RS05940	COG1418	mRNA catabolic process
HC352_RS05945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC352_RS05950	COG1121	(ABC) transporter
HC352_RS05965	COG1725	Transcriptional regulator
HC352_RS05970	COG1131	(ABC) transporter
HC352_RS05985	COG0765	amino acid transport
HC352_RS06000	COG1114	Component of the transport system for branched-chain amino acids
HC352_RS06005	COG1114	Component of the transport system for branched-chain amino acids
HC352_RS06010	COG1285	pathogenesis
HC352_RS06015	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HC352_RS06050	COG0531	amino acid
HC352_RS06060	COG3250	beta-galactosidase activity
HC352_RS06070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HC352_RS06090	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HC352_RS06095	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC352_RS06100	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC352_RS06105	COG1129	ABC transporter
HC352_RS06155	COG1129	ABC transporter
HC352_RS06170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC352_RS06190	COG0745	RESPONSE REGULATOR receiver
HC352_RS06195	COG5002	protein histidine kinase activity
HC352_RS06200	COG0704	Plays a role in the regulation of phosphate uptake
HC352_RS06215	COG1268	BioY protein
HC352_RS06220	COG0736	holo-[acyl-carrier-protein] synthase activity
HC352_RS06225	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC352_RS06230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC352_RS06240	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HC352_RS06240	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HC352_RS06260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC352_RS06300	COG0739	heme binding
HC352_RS06305	COG2177	Part of the ABC transporter FtsEX involved in
HC352_RS06310	COG2884	Cell division ATP-binding protein ftsE
HC352_RS06315	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HC352_RS06375	COG0513	Belongs to the DEAD box helicase family
HC352_RS06380	COG2095	MarC family integral membrane protein
HC352_RS06390	COG0006	proline dipeptidase activity
HC352_RS06415	COG0805	protein transport
HC352_RS06420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC352_RS06435	COG0315	cyclic pyranopterin monophosphate synthase activity
HC352_RS06460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HC352_RS06480	COG0437	4 iron, 4 sulfur cluster binding
HC352_RS06485	COG0243	molybdopterin cofactor binding
HC352_RS06505	COG0746	molybdenum cofactor guanylyltransferase activity
HC352_RS06515	COG1611	Belongs to the LOG family
HC352_RS06525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC352_RS06530	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HC352_RS06565	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HC352_RS06565	COG0662	Cupin 2, conserved barrel domain protein
HC352_RS06580	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HC352_RS06585	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HC352_RS06595	COG0110	maltose O-acetyltransferase activity
HC352_RS06600	COG2197	response regulator
HC352_RS06620	COG3012	SEC-C Motif Domain Protein
HC352_RS06625	COG0039	L-malate dehydrogenase activity
HC352_RS06640	COG0166	Belongs to the GPI family
HC352_RS06650	COG0205	6-phosphofructokinase activity
HC352_RS06675	COG0045	succinate-CoA ligase (ADP-forming) activity
HC352_RS06695	COG0789	Transcriptional regulator
HC352_RS06700	COG0477	Major facilitator Superfamily
HC352_RS06745	COG2801	Transposase and inactivated derivatives
HC352_RS06775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HC352_RS06775	COG0519	Catalyzes the synthesis of GMP from XMP
HC352_RS06785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC352_RS06805	COG0564	pseudouridine synthase activity
HC352_RS06810	COG0857	belongs to the CobB CobQ family
HC352_RS06810	COG0280	phosphate acetyltransferase
HC352_RS06815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HC352_RS06830	COG0114	fumarate hydratase activity
HC352_RS06835	COG0516	GMP reductase activity
HC352_RS06845	COG3634	alkyl hydroperoxide reductase activity
HC352_RS06850	COG0450	alkyl hydroperoxide reductase
HC352_RS06865	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HC352_RS06875	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HC352_RS06880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HC352_RS06885	COG1053	succinate dehydrogenase
HC352_RS06910	COG0802	atpase or kinase
HC352_RS06915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC352_RS06925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HC352_RS06930	COG1072	(Pantothenic acid kinase))
HC352_RS06940	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HC352_RS06945	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HC352_RS06950	COG0101	tRNA pseudouridine synthase activity
HC352_RS06960	COG0203	ribosomal protein L17
HC352_RS06965	COG0202	RNA polymerase activity
HC352_RS06970	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HC352_RS06975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HC352_RS06980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HC352_RS06985	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HC352_RS06995	COG0644	oxidoreductase
HC352_RS07000	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HC352_RS07015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC352_RS07020	COG2271	Major facilitator Superfamily
HC352_RS07025	COG2030	dehydratase
HC352_RS07055	COG0024	Methionine aminopeptidase
HC352_RS07060	COG0563	adenylate kinase activity
HC352_RS07065	COG0201	protein transport
HC352_RS07070	COG0200	Binds to the 23S rRNA
HC352_RS07075	COG1841	ribosomal large subunit assembly
HC352_RS07080	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HC352_RS07090	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HC352_RS07095	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HC352_RS07100	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HC352_RS07105	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HC352_RS07110	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HC352_RS07115	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HC352_RS07120	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HC352_RS07135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HC352_RS07140	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HC352_RS07145	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HC352_RS07150	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HC352_RS07155	COG0089	rRNA binding
HC352_RS07160	COG0088	Forms part of the polypeptide exit tunnel
HC352_RS07165	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HC352_RS07170	COG0051	transcription antitermination factor activity, RNA binding
HC352_RS07175	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HC352_RS07180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HC352_RS07185	COG0049	tRNA binding
HC352_RS07190	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HC352_RS07195	COG0840	transmembrane signaling receptor activity
HC352_RS07200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HC352_RS07205	COG0085	RNA polymerase activity
HC352_RS07210	COG0222	ribosome binding
HC352_RS07215	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HC352_RS07220	COG0572	uridine kinase
HC352_RS07225	COG0081	regulation of translation
HC352_RS07230	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HC352_RS07250	COG0436	Aminotransferase
HC352_RS07260	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HC352_RS07265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HC352_RS07290	COG1666	GTP binding
HC352_RS07300	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HC352_RS07310	COG5401	PFAM Sporulation and spore germination
HC352_RS07315	COG5002	protein histidine kinase activity
HC352_RS07320	COG0745	RESPONSE REGULATOR receiver
HC352_RS07355	COG1316	TRANSCRIPTIONal
HC352_RS07360	COG1316	TRANSCRIPTIONal
HC352_RS07365	COG2205	protein histidine kinase activity
HC352_RS07370	COG0745	RESPONSE REGULATOR receiver
HC352_RS07385	COG0424	maF-like protein
HC352_RS07420	COG1132	(ABC) transporter
HC352_RS07425	COG1132	(ABC) transporter
HC352_RS07430	COG0747	negative chemotaxis
HC352_RS07450	COG0321	lipoyl(octanoyl) transferase activity
HC352_RS07455	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HC352_RS07465	COG1362	aminopeptidase activity
HC352_RS07480	COG2838	Isocitrate dehydrogenase
HC352_RS07490	COG0039	L-malate dehydrogenase activity
HC352_RS07495	COG3971	2-oxopent-4-enoate hydratase activity
HC352_RS07510	COG2195	Cleaves the N-terminal amino acid of tripeptides
HC352_RS07525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC352_RS07530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC352_RS07550	COG0431	NADPH-dependent FMN reductase
HC352_RS07555	COG0783	Belongs to the Dps family
HC352_RS07560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC352_RS07565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HC352_RS07615	COG0733	neurotransmitter:sodium symporter activity
HC352_RS07635	COG0012	GTP binding
HC352_RS07640	COG1322	Protein conserved in bacteria
HC352_RS07645	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HC352_RS07650	COG1570	exodeoxyribonuclease VII activity
HC352_RS07655	COG1722	exodeoxyribonuclease VII activity
HC352_RS07665	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HC352_RS07675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HC352_RS07680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HC352_RS07695	COG1131	(ABC) transporter
HC352_RS07710	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HC352_RS07730	COG0148	phosphopyruvate hydratase activity
HC352_RS07740	COG0193	aminoacyl-tRNA hydrolase activity
HC352_RS07750	COG1120	ATPase activity
HC352_RS07755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC352_RS07770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HC352_RS07780	COG1309	transcriptional regulator
HC352_RS07785	COG4152	abc transporter atp-binding protein
HC352_RS07790	COG1668	transmembrane transport
HC352_RS07800	COG0488	(ABC) transporter
HC352_RS07805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HC352_RS07810	COG2190	(PTS) system
HC352_RS07815	COG1263	PTS System
HC352_RS07815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC352_RS07820	COG3711	transcriptional antiterminator
HC352_RS07825	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HC352_RS07835	COG0084	hydrolase, TatD family'
HC352_RS07840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC352_RS07845	COG1335	isochorismatase
HC352_RS07850	COG2409	Drug exporters of the RND superfamily
HC352_RS07870	COG1131	(ABC) transporter
HC352_RS07880	COG4585	Histidine kinase
HC352_RS07885	COG2197	response regulator
HC352_RS07890	COG2813	Specifically methylates the guanine in position
HC352_RS07920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HC352_RS07930	COG1970	mechanosensitive ion channel activity
HC352_RS07960	COG0791	NLP P60 protein
HC352_RS07960	COG3103	Sh3 type 3 domain protein
HC352_RS07960	COG1388	LysM domain
HC352_RS07970	COG2252	PERMEase
HC352_RS07975	COG1482	cell wall glycoprotein biosynthetic process
HC352_RS07985	COG1278	Cold shock
HC352_RS07995	COG1842	Phage shock protein A
HC352_RS08005	COG0745	RESPONSE REGULATOR receiver
HC352_RS08010	COG2205	protein histidine kinase activity
HC352_RS08040	COG0459	protein refolding
HC352_RS08055	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HC352_RS08065	COG0156	8-amino-7-oxononanoate synthase activity
HC352_RS08070	COG1063	alcohol dehydrogenase
HC352_RS08075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HC352_RS08085	COG1115	amino acid carrier protein
HC352_RS08110	COG3842	ATPase activity
HC352_RS08120	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HC352_RS08150	COG2233	PERMEase
HC352_RS08170	COG0215	cysteine-tRNA ligase activity
HC352_RS08180	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HC352_RS08185	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HC352_RS08190	COG1329	Transcriptional regulator
HC352_RS08195	COG0588	phosphoglycerate mutase activity
HC352_RS08205	COG0446	pyridine nucleotide-disulphide oxidoreductase
HC352_RS08260	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HC352_RS08325	COG3843	relaxase mobilization nuclease domain protein
HC352_RS08365	COG0741	lytic transglycosylase activity
HC352_RS08365	COG0739	heme binding
HC352_RS08365	COG1196	nuclear chromosome segregation
HC352_RS08415	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HC352_RS08420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HC352_RS08420	COG1754	DNA topoisomerase type I activity
HC352_RS08425	COG2890	protein-(glutamine-N5) methyltransferase activity
HC352_RS08485	COG0596	Alpha beta hydrolase
HC352_RS08495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC352_RS08510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC352_RS08530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC352_RS08540	COG0738	Major facilitator superfamily
HC352_RS08545	COG2390	Transcriptional regulator
HC352_RS08570	COG4868	Belongs to the UPF0371 family
HC352_RS08595	COG0590	tRNA wobble adenosine to inosine editing
HC352_RS08600	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HC352_RS08630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HC352_RS08635	COG0561	phosphatase activity
HC352_RS08690	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HC352_RS08725	COG0471	metal ion transport
HC352_RS08740	COG0189	ligase activity
HC352_RS08740	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HC352_RS08775	COG1643	Atp-dependent helicase
HC352_RS08790	COG0343	queuine tRNA-ribosyltransferase activity
HC352_RS08820	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HC352_RS08825	COG0305	Participates in initiation and elongation during chromosome replication
HC352_RS08830	COG0534	Mate efflux family protein
HC352_RS08840	COG0359	binds to the 23S rRNA
HC352_RS08845	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HC352_RS08855	COG0360	Binds together with S18 to 16S ribosomal RNA
HC352_RS08860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC352_RS08865	COG0628	permease
HC352_RS08875	COG0617	tRNA 3'-terminal CCA addition
HC352_RS08895	COG0492	ferredoxin-NADP+ reductase activity
HC352_RS08900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC352_RS08915	COG0357	Ribosomal RNA small subunit methyltransferase G
HC352_RS08920	COG1847	R3H domain protein
HC352_RS08925	COG0706	membrane insertase activity
HC352_RS08935	COG0594	ribonuclease P activity
HC352_RS08940	COG0230	Belongs to the bacterial ribosomal protein bL34 family