locus-tag	class	description
H2O17_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H2O17_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H2O17_RS00025	COG0187	DNA topoisomerase II activity
H2O17_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H2O17_RS00035	COG3266	domain, Protein
H2O17_RS00055	COG1432	Conserved Protein
H2O17_RS00080	COG1937	Protein conserved in bacteria
H2O17_RS00100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2O17_RS00115	COG1228	amidohydrolase
H2O17_RS00120	COG1473	amidohydrolase
H2O17_RS00145	COG0667	Aldo Keto reductase
H2O17_RS00160	COG2910	NAD(P)H-binding
H2O17_RS00165	COG1064	alcohol dehydrogenase
H2O17_RS00170	COG0604	alcohol dehydrogenase
H2O17_RS00195	COG3764	Sortase (surface protein transpeptidase)
H2O17_RS00210	COG0768	penicillin binding
H2O17_RS00225	COG1716	ATPase activity
H2O17_RS00230	COG1716	ATPase activity
H2O17_RS00230	COG0842	Transport permease protein
H2O17_RS00230	COG1131	(ABC) transporter
H2O17_RS00245	COG1028	Short-chain dehydrogenase reductase Sdr
H2O17_RS00250	COG1132	(ABC) transporter
H2O17_RS00255	COG1132	(ABC) transporter
H2O17_RS00275	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H2O17_RS00280	COG1854	S-ribosylhomocysteine lyase activity
H2O17_RS00300	COG0305	Participates in initiation and elongation during chromosome replication
H2O17_RS00305	COG0351	phosphomethylpyrimidine kinase
H2O17_RS00345	COG0343	queuine tRNA-ribosyltransferase activity
H2O17_RS00355	COG0561	phosphatase activity
H2O17_RS00360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2O17_RS00385	COG1136	(ABC) transporter
H2O17_RS00395	COG2197	response regulator
H2O17_RS00400	COG1643	Atp-dependent helicase
H2O17_RS00425	COG0095	Lipoate-protein ligase
H2O17_RS00450	COG3250	beta-galactosidase activity
H2O17_RS00460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H2O17_RS00475	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H2O17_RS00505	COG0246	Mannitol dehydrogenase
H2O17_RS00510	COG1312	Catalyzes the dehydration of D-mannonate
H2O17_RS00515	COG0800	Aldolase
H2O17_RS00520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2O17_RS00525	COG0477	Major facilitator Superfamily
H2O17_RS00540	COG1063	alcohol dehydrogenase
H2O17_RS00600	COG0561	phosphatase activity
H2O17_RS00605	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H2O17_RS00610	COG1597	lipid kinase activity
H2O17_RS00610	COG1803	Methylglyoxal synthase
H2O17_RS00615	COG0077	Prephenate dehydratase
H2O17_RS00625	COG1215	transferase activity, transferring glycosyl groups
H2O17_RS00645	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H2O17_RS00680	COG4974	Belongs to the 'phage' integrase family
H2O17_RS00695	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H2O17_RS00705	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H2O17_RS00715	COG0577	efflux transmembrane transporter activity
H2O17_RS00715	COG1136	(ABC) transporter
H2O17_RS00720	COG0577	efflux transmembrane transporter activity
H2O17_RS00735	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H2O17_RS00740	COG0747	negative chemotaxis
H2O17_RS00755	COG0601	transmembrane transport
H2O17_RS00765	COG0006	proline dipeptidase activity
H2O17_RS00795	COG3938	Belongs to the proline racemase family
H2O17_RS00805	COG1802	Transcriptional regulator
H2O17_RS00820	COG1408	metallophosphoesterase
H2O17_RS00825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H2O17_RS00825	COG4499	WXG100 protein secretion system (Wss), protein YukC
H2O17_RS00855	COG0596	Alpha beta hydrolase
H2O17_RS00905	COG1111	helicase
H2O17_RS00905	COG1205	dead DEAH box helicase
H2O17_RS00925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H2O17_RS00925	COG1754	DNA topoisomerase type I activity
H2O17_RS00930	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H2O17_RS00935	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H2O17_RS00980	COG1278	Cold shock
H2O17_RS00985	COG3328	transposase activity
H2O17_RS00995	COG3979	chitinase
H2O17_RS01000	COG5001	Diguanylate cyclase
H2O17_RS01000	COG3300	MHYT domain
H2O17_RS01015	COG1116	anion transmembrane transporter activity
H2O17_RS01020	COG0588	phosphoglycerate mutase activity
H2O17_RS01025	COG0704	Plays a role in the regulation of phosphate uptake
H2O17_RS01030	COG5002	protein histidine kinase activity
H2O17_RS01035	COG0745	RESPONSE REGULATOR receiver
H2O17_RS01040	COG1329	Transcriptional regulator
H2O17_RS01045	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H2O17_RS01050	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H2O17_RS01060	COG0215	cysteine-tRNA ligase activity
H2O17_RS01090	COG2066	Belongs to the glutaminase family
H2O17_RS01095	COG3415	Transposase
H2O17_RS01095	COG2801	Transposase and inactivated derivatives
H2O17_RS01140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H2O17_RS01160	COG3842	ATPase activity
H2O17_RS01190	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H2O17_RS01235	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H2O17_RS01250	COG0459	protein refolding
H2O17_RS01255	COG0179	Fumarylacetoacetate (FAA) hydrolase
H2O17_RS01275	COG2205	protein histidine kinase activity
H2O17_RS01280	COG0745	RESPONSE REGULATOR receiver
H2O17_RS01285	COG1842	Phage shock protein A
H2O17_RS01295	COG1278	Cold shock
H2O17_RS01305	COG1482	cell wall glycoprotein biosynthetic process
H2O17_RS01310	COG2252	PERMEase
H2O17_RS01315	COG2814	Major facilitator Superfamily
H2O17_RS01325	COG1321	iron dependent repressor
H2O17_RS01365	COG1970	mechanosensitive ion channel activity
H2O17_RS01375	COG0154	amidase activity
H2O17_RS01415	COG3415	Transposase
H2O17_RS01415	COG2801	Transposase and inactivated derivatives
H2O17_RS01445	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H2O17_RS01460	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H2O17_RS01480	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2O17_RS01495	COG1732	Glycine betaine
H2O17_RS01500	COG1174	glycine betaine transport
H2O17_RS01505	COG1174	glycine betaine transport
H2O17_RS01515	COG1695	Transcriptional regulator
H2O17_RS01525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2O17_RS01550	COG1175	transmembrane transport
H2O17_RS01555	COG3833	ABC-type maltose transport systems, permease component
H2O17_RS01560	COG1940	carbohydrate kinase activity
H2O17_RS01565	COG0778	Nitroreductase
H2O17_RS01580	COG0366	Alpha amylase catalytic
H2O17_RS01600	COG2076	Multidrug Resistance protein
H2O17_RS01610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H2O17_RS01615	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H2O17_RS01630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2O17_RS01635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2O17_RS01655	COG1335	isochorismatase
H2O17_RS01660	COG1349	DNA-binding transcription factor activity
H2O17_RS01670	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H2O17_RS01670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2O17_RS01670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2O17_RS01675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2O17_RS01680	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2O17_RS01685	COG0084	hydrolase, TatD family'
H2O17_RS01695	COG0390	transport system, permease component
H2O17_RS01700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H2O17_RS01725	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H2O17_RS01740	COG0490	domain, Protein
H2O17_RS01740	COG0471	metal ion transport
H2O17_RS01745	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H2O17_RS01750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H2O17_RS01760	COG2197	response regulator
H2O17_RS01775	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H2O17_RS01780	COG0488	(ABC) transporter
H2O17_RS01795	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H2O17_RS01825	COG4152	abc transporter atp-binding protein
H2O17_RS01840	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H2O17_RS01860	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H2O17_RS01865	COG0193	aminoacyl-tRNA hydrolase activity
H2O17_RS01880	COG0148	phosphopyruvate hydratase activity
H2O17_RS01900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H2O17_RS01925	COG1131	(ABC) transporter
H2O17_RS01935	COG0545	Peptidyl-prolyl cis-trans isomerase
H2O17_RS01940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H2O17_RS01945	COG1349	DNA-binding transcription factor activity
H2O17_RS01950	COG0698	ribose 5-phosphate isomerase
H2O17_RS01955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H2O17_RS01960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H2O17_RS01975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2O17_RS01980	COG1722	exodeoxyribonuclease VII activity
H2O17_RS01985	COG1570	exodeoxyribonuclease VII activity
H2O17_RS01990	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H2O17_RS02000	COG1322	Protein conserved in bacteria
H2O17_RS02005	COG0012	GTP binding
H2O17_RS02090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2O17_RS02095	COG0602	queuosine metabolic process
H2O17_RS02100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H2O17_RS02100	COG1328	CTP reductase activity
H2O17_RS02110	COG1132	(ABC) transporter
H2O17_RS02150	COG0644	oxidoreductase
H2O17_RS02155	COG0489	protein tyrosine kinase activity
H2O17_RS02160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H2O17_RS02170	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H2O17_RS02175	COG0702	epimerase
H2O17_RS02215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H2O17_RS02240	COG1131	(ABC) transporter
H2O17_RS02290	COG1442	glycosyl transferase family 8
H2O17_RS02290	COG1216	Glycosyl transferase, family 2
H2O17_RS02295	COG0438	transferase activity, transferring glycosyl groups
H2O17_RS02315	COG3189	MarR family transcriptional regulator
H2O17_RS02345	COG0601	transmembrane transport
H2O17_RS02355	COG4172	Belongs to the ABC transporter superfamily
H2O17_RS02360	COG0242	peptide deformylase activity
H2O17_RS02365	COG1113	amino acid transport
H2O17_RS02375	COG0601	transmembrane transport
H2O17_RS02380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2O17_RS02395	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H2O17_RS02415	COG3477	response to acidic pH
H2O17_RS02430	COG1113	amino acid transport
H2O17_RS02445	COG1022	Amp-dependent synthetase and ligase
H2O17_RS02460	COG1131	(ABC) transporter
H2O17_RS02480	COG3158	transport of potassium into the cell
H2O17_RS02485	COG1362	aminopeptidase activity
H2O17_RS02490	COG0318	PFAM AMP-dependent synthetase and ligase
H2O17_RS02495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H2O17_RS02500	COG0321	lipoyl(octanoyl) transferase activity
H2O17_RS02520	COG0747	negative chemotaxis
H2O17_RS02565	COG2171	N-acyltransferase activity
H2O17_RS02585	COG0745	RESPONSE REGULATOR receiver
H2O17_RS02590	COG2205	protein histidine kinase activity
H2O17_RS02610	COG1316	TRANSCRIPTIONal
H2O17_RS02615	COG1316	TRANSCRIPTIONal
H2O17_RS02630	COG1088	dTDP-glucose 4,6-dehydratase activity
H2O17_RS02670	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H2O17_RS02675	COG0463	Glycosyl transferase, family 2
H2O17_RS02700	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H2O17_RS02740	COG0745	RESPONSE REGULATOR receiver
H2O17_RS02745	COG5000	phosphorelay sensor kinase activity
H2O17_RS02745	COG5002	protein histidine kinase activity
H2O17_RS02750	COG5401	PFAM Sporulation and spore germination
H2O17_RS02760	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H2O17_RS02770	COG1666	GTP binding
H2O17_RS02795	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H2O17_RS02800	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H2O17_RS02810	COG0436	Aminotransferase
H2O17_RS02825	COG0250	Participates in transcription elongation, termination and antitermination
H2O17_RS02830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H2O17_RS02835	COG0081	regulation of translation
H2O17_RS02850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H2O17_RS02855	COG0222	ribosome binding
H2O17_RS02860	COG0085	RNA polymerase activity
H2O17_RS02865	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H2O17_RS02870	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H2O17_RS02875	COG0049	tRNA binding
H2O17_RS02880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H2O17_RS02885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H2O17_RS02900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2O17_RS02900	COG1263	PTS System
H2O17_RS02905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2O17_RS02905	COG1263	PTS System
H2O17_RS02905	COG2190	(PTS) system
H2O17_RS02915	COG0051	transcription antitermination factor activity, RNA binding
H2O17_RS02920	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H2O17_RS02925	COG0088	Forms part of the polypeptide exit tunnel
H2O17_RS02930	COG0089	rRNA binding
H2O17_RS02935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H2O17_RS02940	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H2O17_RS02945	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H2O17_RS02950	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H2O17_RS02955	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H2O17_RS02960	COG0255	Belongs to the universal ribosomal protein uL29 family
H2O17_RS02965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H2O17_RS02970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H2O17_RS02975	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H2O17_RS02980	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H2O17_RS02985	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H2O17_RS02990	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H2O17_RS02995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H2O17_RS03005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H2O17_RS03010	COG1841	ribosomal large subunit assembly
H2O17_RS03015	COG0200	Binds to the 23S rRNA
H2O17_RS03025	COG0563	adenylate kinase activity
H2O17_RS03030	COG0024	Methionine aminopeptidase
H2O17_RS03035	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H2O17_RS03040	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H2O17_RS03045	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H2O17_RS03050	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H2O17_RS03055	COG0202	RNA polymerase activity
H2O17_RS03060	COG0203	ribosomal protein L17
H2O17_RS03065	COG1940	carbohydrate kinase activity
H2O17_RS03070	COG0101	tRNA pseudouridine synthase activity
H2O17_RS03075	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H2O17_RS03080	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H2O17_RS03090	COG1072	(Pantothenic acid kinase))
H2O17_RS03095	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H2O17_RS03105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H2O17_RS03110	COG0802	atpase or kinase
H2O17_RS03135	COG1053	succinate dehydrogenase
H2O17_RS03140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H2O17_RS03145	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H2O17_RS03150	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H2O17_RS03160	COG2176	DNA-directed DNA polymerase activity
H2O17_RS03165	COG0516	GMP reductase activity
H2O17_RS03175	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H2O17_RS03175	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H2O17_RS03180	COG0726	polysaccharide deacetylase
H2O17_RS03200	COG4555	ABC transporter
H2O17_RS03235	COG0644	oxidoreductase
H2O17_RS03275	COG0644	oxidoreductase
H2O17_RS03285	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H2O17_RS03305	COG3655	Transcriptional regulator
H2O17_RS03310	COG1028	Short-chain dehydrogenase reductase Sdr
H2O17_RS03315	COG0028	Belongs to the TPP enzyme family
H2O17_RS03320	COG1024	Enoyl-CoA hydratase
H2O17_RS03330	COG1960	acyl-CoA dehydrogenase activity
H2O17_RS03335	COG0644	oxidoreductase
H2O17_RS03340	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H2O17_RS03360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H2O17_RS03365	COG0280	phosphate acetyltransferase
H2O17_RS03365	COG0857	belongs to the CobB CobQ family
H2O17_RS03370	COG0564	pseudouridine synthase activity
H2O17_RS03375	COG0519	Catalyzes the synthesis of GMP from XMP
H2O17_RS03375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H2O17_RS03390	COG4974	Belongs to the 'phage' integrase family
H2O17_RS03420	COG3177	Filamentation induced by cAMP protein fic
H2O17_RS03455	COG0792	nuclease activity
H2O17_RS03480	COG1192	Involved in chromosome partitioning
H2O17_RS03535	COG0583	DNA-binding transcription factor activity
H2O17_RS03550	COG1882	Formate acetyltransferase
H2O17_RS03555	COG1882	Formate acetyltransferase
H2O17_RS03565	COG1012	belongs to the aldehyde dehydrogenase family
H2O17_RS03575	COG0045	succinate-CoA ligase (ADP-forming) activity
H2O17_RS03585	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H2O17_RS03590	COG0363	glucosamine-6-phosphate deaminase activity
H2O17_RS03605	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H2O17_RS03610	COG0138	bifunctional purine biosynthesis protein purh
H2O17_RS03615	COG1012	belongs to the aldehyde dehydrogenase family
H2O17_RS03630	COG1253	flavin adenine dinucleotide binding
H2O17_RS03640	COG0205	6-phosphofructokinase activity
H2O17_RS03645	COG0166	Belongs to the GPI family
H2O17_RS03650	COG0039	L-malate dehydrogenase activity
H2O17_RS03655	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H2O17_RS03655	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H2O17_RS03660	COG4770	biotin carboxylase activity
H2O17_RS03665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H2O17_RS03675	COG0736	holo-[acyl-carrier-protein] synthase activity
H2O17_RS03680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H2O17_RS03685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H2O17_RS03700	COG0662	Cupin 2, conserved barrel domain protein
H2O17_RS03700	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H2O17_RS03740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H2O17_RS03750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H2O17_RS03755	COG1611	Belongs to the LOG family
H2O17_RS03795	COG2239	Acts as a magnesium transporter
H2O17_RS03800	COG0006	proline dipeptidase activity
H2O17_RS03810	COG2095	MarC family integral membrane protein
H2O17_RS03815	COG0561	phosphatase activity
H2O17_RS03820	COG0513	Belongs to the DEAD box helicase family
H2O17_RS03830	COG0210	DNA helicase
H2O17_RS03845	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H2O17_RS03850	COG2884	Cell division ATP-binding protein ftsE
H2O17_RS03855	COG2177	Part of the ABC transporter FtsEX involved in
H2O17_RS03860	COG0739	heme binding
H2O17_RS03865	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H2O17_RS03895	COG2226	methyltransferase
H2O17_RS03910	COG0477	Major facilitator Superfamily
H2O17_RS03925	COG0640	Transcriptional regulator
H2O17_RS04120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H2O17_RS04220	COG1063	alcohol dehydrogenase
H2O17_RS04245	COG1674	ftsk spoiiie
H2O17_RS04335	COG0671	phosphoesterase, PA-phosphatase related
H2O17_RS04360	COG3421	Type III restriction
H2O17_RS04365	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H2O17_RS04570	COG1022	Amp-dependent synthetase and ligase
H2O17_RS04585	COG0640	Transcriptional regulator
H2O17_RS04590	COG2217	Heavy metal translocating P-type atpase
H2O17_RS04615	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H2O17_RS04625	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H2O17_RS04630	COG1234	tRNA 3'-trailer cleavage
H2O17_RS04640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H2O17_RS04660	COG1470	cell adhesion involved in biofilm formation
H2O17_RS04670	COG0477	Major facilitator Superfamily
H2O17_RS04705	COG1131	(ABC) transporter
H2O17_RS04720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H2O17_RS04745	COG0395	ABC-type sugar transport system, permease component
H2O17_RS04750	COG1175	transmembrane transport
H2O17_RS04755	COG1653	transport
H2O17_RS04780	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H2O17_RS04785	COG0066	3-isopropylmalate dehydratase activity
H2O17_RS04790	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H2O17_RS04815	COG1181	Belongs to the D-alanine--D-alanine ligase family
H2O17_RS04835	COG2348	transferase activity, transferring amino-acyl groups
H2O17_RS04840	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H2O17_RS04845	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H2O17_RS04850	COG0742	ribosomal rna small subunit methyltransferase
H2O17_RS04855	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H2O17_RS04870	COG0571	ribonuclease III activity
H2O17_RS04875	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H2O17_RS04900	COG1472	Belongs to the glycosyl hydrolase 3 family
H2O17_RS04910	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H2O17_RS04915	COG4988	ABC transporter
H2O17_RS04920	COG1294	oxidase, subunit
H2O17_RS04925	COG1271	oxidase subunit
H2O17_RS04930	COG1530	ribonuclease E activity
H2O17_RS04935	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H2O17_RS04945	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H2O17_RS04950	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H2O17_RS04960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2O17_RS04965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H2O17_RS04970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H2O17_RS04980	COG0799	negative regulation of ribosome biogenesis
H2O17_RS04985	COG0406	alpha-ribazole phosphatase activity
H2O17_RS05030	COG1902	pentaerythritol trinitrate reductase activity
H2O17_RS05045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2O17_RS05050	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2O17_RS05055	COG1120	ATPase activity
H2O17_RS05085	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H2O17_RS05100	COG3588	fructose-bisphosphate aldolase
H2O17_RS05135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H2O17_RS05140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H2O17_RS05170	COG0667	Aldo Keto reductase
H2O17_RS05190	COG0604	alcohol dehydrogenase
H2O17_RS05190	COG3321	synthase
H2O17_RS05190	COG1028	Short-chain dehydrogenase reductase Sdr
H2O17_RS05195	COG1764	response to oxidative stress
H2O17_RS05200	COG1846	Transcriptional regulator
H2O17_RS05210	COG4591	ABC-type transport system involved in lipoprotein release permease component
H2O17_RS05210	COG1136	(ABC) transporter
H2O17_RS05225	COG0431	NADPH-dependent FMN reductase
H2O17_RS05240	COG0577	efflux transmembrane transporter activity
H2O17_RS05240	COG1136	(ABC) transporter
H2O17_RS05265	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H2O17_RS05280	COG1136	(ABC) transporter
H2O17_RS05290	COG0534	Mate efflux family protein
H2O17_RS05305	COG1464	Belongs to the NlpA lipoprotein family
H2O17_RS05310	COG2011	ABC-type metal ion transport system permease component
H2O17_RS05315	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H2O17_RS05325	COG0813	purine-nucleoside phosphorylase activity
H2O17_RS05345	COG0495	leucyl-tRNA aminoacylation
H2O17_RS05370	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H2O17_RS05375	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H2O17_RS05390	COG0268	Binds directly to 16S ribosomal RNA
H2O17_RS05400	COG1316	TRANSCRIPTIONal
H2O17_RS05425	COG0481	GTPase activity
H2O17_RS05430	COG0483	inositol monophosphate 1-phosphatase activity
H2O17_RS05435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H2O17_RS05450	COG1420	regulation of RNA biosynthetic process
H2O17_RS05455	COG0484	heat shock protein binding
H2O17_RS05470	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H2O17_RS05480	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H2O17_RS05490	COG0631	protein serine/threonine phosphatase activity
H2O17_RS05505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H2O17_RS05510	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H2O17_RS05515	COG0519	Catalyzes the synthesis of GMP from XMP
H2O17_RS05520	COG1381	Involved in DNA repair and RecF pathway recombination
H2O17_RS05525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H2O17_RS05550	COG0131	Imidazoleglycerol-phosphate dehydratase
H2O17_RS05560	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H2O17_RS05565	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H2O17_RS05575	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H2O17_RS05580	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H2O17_RS05590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H2O17_RS05600	COG0674	pyruvate-flavodoxin oxidoreductase activity
H2O17_RS05605	COG1013	pyruvate-flavodoxin oxidoreductase activity
H2O17_RS05620	COG0477	Major facilitator Superfamily
H2O17_RS05625	COG0778	Nitroreductase
H2O17_RS05635	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H2O17_RS05640	COG0165	Argininosuccinate lyase
H2O17_RS05645	COG2094	Belongs to the DNA glycosylase MPG family
H2O17_RS05650	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H2O17_RS05685	COG0647	UMP catabolic process
H2O17_RS05700	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H2O17_RS05725	COG0728	peptidoglycan biosynthetic process
H2O17_RS05730	COG0504	CTP synthase activity
H2O17_RS05755	COG0719	Fe-S assembly protein
H2O17_RS05765	COG0396	ATPase activity
H2O17_RS05780	COG2151	metal-sulfur cluster biosynthetic enzyme
H2O17_RS05785	COG0488	(ABC) transporter
H2O17_RS05800	COG0598	Magnesium transport protein CorA
H2O17_RS05805	COG3830	Belongs to the UPF0237 family
H2O17_RS05805	COG0560	Phosphoserine phosphatase
H2O17_RS05815	COG0297	glycogen (starch) synthase activity
H2O17_RS05820	COG1119	ATPase activity
H2O17_RS05845	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H2O17_RS05850	COG1881	PFAM PEBP family protein
H2O17_RS05865	COG0587	DNA-directed DNA polymerase activity
H2O17_RS05880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H2O17_RS05885	COG1263	PTS System
H2O17_RS05885	COG2190	(PTS) system
H2O17_RS05885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2O17_RS05890	COG2723	6-phospho-beta-galactosidase activity
H2O17_RS05910	COG1404	Belongs to the peptidase S8 family
H2O17_RS05920	COG0667	Aldo Keto reductase
H2O17_RS05925	COG1968	undecaprenyl-diphosphatase activity
H2O17_RS05940	COG1222	aaa ATPase
H2O17_RS05945	COG4122	O-methyltransferase activity
H2O17_RS05955	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H2O17_RS05965	COG0107	imidazoleglycerol-phosphate synthase activity
H2O17_RS05980	COG0134	indole-3-glycerol-phosphate synthase activity
H2O17_RS05985	COG0133	tryptophan synthase activity
H2O17_RS05995	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H2O17_RS06000	COG0069	glutamate synthase activity
H2O17_RS06000	COG0070	glutamate synthase
H2O17_RS06000	COG0067	glutamate synthase
H2O17_RS06035	COG2226	methyltransferase
H2O17_RS06040	COG0539	negative regulation of cytoplasmic translation
H2O17_RS06045	COG1959	2 iron, 2 sulfur cluster binding
H2O17_RS06050	COG0626	cystathionine gamma-synthase activity
H2O17_RS06055	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H2O17_RS06055	COG0237	dephospho-CoA kinase activity
H2O17_RS06060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H2O17_RS06065	COG0556	nucleotide-excision repair
H2O17_RS06090	COG0322	excinuclease ABC activity
H2O17_RS06095	COG1660	Displays ATPase and GTPase activities
H2O17_RS06105	COG1481	regulation of sporulation
H2O17_RS06110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H2O17_RS06115	COG0126	phosphoglycerate kinase activity
H2O17_RS06120	COG0149	triose-phosphate isomerase activity
H2O17_RS06125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H2O17_RS06155	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H2O17_RS06160	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H2O17_RS06170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H2O17_RS06175	COG1160	GTP binding
H2O17_RS06185	COG0561	phosphatase activity
H2O17_RS06190	COG0519	Catalyzes the synthesis of GMP from XMP
H2O17_RS06195	COG1309	transcriptional regulator
H2O17_RS06200	COG1053	succinate dehydrogenase
H2O17_RS06205	COG2235	arginine
H2O17_RS06230	COG0488	(ABC) transporter
H2O17_RS06250	COG0789	Transcriptional regulator
H2O17_RS06360	COG4221	oxidoreductase activity
H2O17_RS06360	COG3321	synthase
H2O17_RS06360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2O17_RS06360	COG0604	alcohol dehydrogenase
H2O17_RS06370	COG0747	negative chemotaxis
H2O17_RS06375	COG0601	transmembrane transport
H2O17_RS06395	COG2217	Heavy metal translocating P-type atpase
H2O17_RS06400	COG0488	(ABC) transporter
H2O17_RS06420	COG1874	Beta-galactosidase
H2O17_RS06430	COG2211	Major facilitator Superfamily
H2O17_RS06435	COG1063	alcohol dehydrogenase
H2O17_RS06440	COG1716	ATPase activity
H2O17_RS06460	COG0443	Heat shock 70 kDa protein
H2O17_RS06470	COG1216	Glycosyl transferase, family 2
H2O17_RS06485	COG1597	lipid kinase activity
H2O17_RS06510	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H2O17_RS06515	COG0140	phosphoribosyl-ATP diphosphatase activity
H2O17_RS06520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2O17_RS06525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2O17_RS06530	COG2409	Drug exporters of the RND superfamily
H2O17_RS06535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2O17_RS06540	COG2326	polyphosphate kinase activity
H2O17_RS06545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H2O17_RS06555	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H2O17_RS06565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H2O17_RS06575	COG1758	RNA polymerase activity
H2O17_RS06580	COG0194	GDP metabolic process
H2O17_RS06585	COG0194	GDP metabolic process
H2O17_RS06590	COG0284	orotidine-5'-phosphate decarboxylase activity
H2O17_RS06595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H2O17_RS06605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H2O17_RS06610	COG0540	Belongs to the ATCase OTCase family
H2O17_RS06615	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H2O17_RS06620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H2O17_RS06625	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H2O17_RS06640	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H2O17_RS06660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H2O17_RS06665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H2O17_RS06675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H2O17_RS06690	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H2O17_RS06695	COG0477	Major facilitator Superfamily
H2O17_RS06705	COG1966	Carbon starvation protein
H2O17_RS06720	COG0300	oxidoreductase activity
H2O17_RS06730	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H2O17_RS06745	COG0137	argininosuccinate synthase activity
H2O17_RS06755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H2O17_RS06760	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H2O17_RS06770	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H2O17_RS06785	COG0124	histidyl-tRNA synthetase
H2O17_RS06790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2O17_RS06795	COG1196	nuclear chromosome segregation
H2O17_RS06805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H2O17_RS06810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H2O17_RS06815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H2O17_RS06820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H2O17_RS06830	COG2255	four-way junction helicase activity
H2O17_RS06835	COG0632	four-way junction helicase activity
H2O17_RS06840	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H2O17_RS06845	COG0217	transcriptional regulatory protein
H2O17_RS06850	COG1051	belongs to the nudix hydrolase family
H2O17_RS06865	COG0438	transferase activity, transferring glycosyl groups
H2O17_RS06895	COG1175	transmembrane transport
H2O17_RS06900	COG0395	ABC-type sugar transport system, permease component
H2O17_RS06915	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H2O17_RS07000	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H2O17_RS07005	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H2O17_RS07010	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H2O17_RS07020	COG0569	domain protein
H2O17_RS07055	COG1435	thymidine kinase activity
H2O17_RS07070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H2O17_RS07080	COG0187	DNA topoisomerase II activity
H2O17_RS07090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H2O17_RS07095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H2O17_RS07100	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H2O17_RS07100	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H2O17_RS07105	COG0509	glycine decarboxylation via glycine cleavage system
H2O17_RS07110	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H2O17_RS07130	COG0477	Major facilitator Superfamily
H2O17_RS07145	COG0741	lytic transglycosylase activity
H2O17_RS07150	COG2815	serine threonine protein kinase
H2O17_RS07150	COG0515	serine threonine protein kinase
H2O17_RS07155	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H2O17_RS07180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H2O17_RS07210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H2O17_RS07220	COG0167	dihydroorotate dehydrogenase activity
H2O17_RS07230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H2O17_RS07240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2O17_RS07245	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2O17_RS07255	COG0174	glutamine synthetase
H2O17_RS07260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2O17_RS07265	COG0765	amino acid transport
H2O17_RS07275	COG0406	alpha-ribazole phosphatase activity
H2O17_RS07280	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H2O17_RS07285	COG0174	glutamine synthetase
H2O17_RS07295	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H2O17_RS07320	COG3022	response to hydroperoxide
H2O17_RS07330	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H2O17_RS07340	COG0446	pyridine nucleotide-disulphide oxidoreductase
H2O17_RS07370	COG1522	sequence-specific DNA binding
H2O17_RS07380	COG0494	nUDIX hydrolase
H2O17_RS07385	COG0028	Belongs to the TPP enzyme family
H2O17_RS07395	COG0393	Putative heavy-metal-binding
H2O17_RS07400	COG1126	abc transporter atp-binding protein
H2O17_RS07405	COG0765	amino acid transport
H2O17_RS07410	COG0765	amino acid transport
H2O17_RS07415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2O17_RS07435	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H2O17_RS07440	COG1834	amidinotransferase
H2O17_RS07455	COG3559	Exporter of polyketide antibiotics
H2O17_RS07460	COG1131	(ABC) transporter
H2O17_RS07485	COG2226	methyltransferase
H2O17_RS07500	COG0419	ATPase involved in DNA repair
H2O17_RS07530	COG0328	RNA-DNA hybrid ribonuclease activity
H2O17_RS07545	COG0488	(ABC) transporter
H2O17_RS07560	COG2826	transposase and inactivated derivatives, IS30 family
H2O17_RS07585	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H2O17_RS07605	COG0009	L-threonylcarbamoyladenylate synthase
H2O17_RS07665	COG0805	protein transport
H2O17_RS07670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H2O17_RS07700	COG0693	protein deglycase activity
H2O17_RS07705	COG1064	alcohol dehydrogenase
H2O17_RS07720	COG0358	DNA primase activity
H2O17_RS07735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H2O17_RS07740	COG0423	glycine-tRNA ligase activity
H2O17_RS07745	COG0803	Belongs to the bacterial solute-binding protein 9 family
H2O17_RS07750	COG1121	(ABC) transporter
H2O17_RS07755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H2O17_RS07760	COG0735	belongs to the Fur family
H2O17_RS07775	COG0587	DNA-directed DNA polymerase activity
H2O17_RS07790	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H2O17_RS07805	COG1799	cell septum assembly
H2O17_RS07815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H2O17_RS07825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H2O17_RS07835	COG0772	Belongs to the SEDS family
H2O17_RS07840	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H2O17_RS07845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H2O17_RS07850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H2O17_RS07855	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H2O17_RS07860	COG0768	penicillin binding
H2O17_RS07870	COG0275	rRNA processing
H2O17_RS07875	COG2001	Belongs to the MraZ family
H2O17_RS07885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2O17_RS07910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H2O17_RS07915	COG0318	PFAM AMP-dependent synthetase and ligase
H2O17_RS07920	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H2O17_RS07930	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H2O17_RS07945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H2O17_RS07950	COG2813	Specifically methylates the guanine in position
H2O17_RS07955	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H2O17_RS07960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H2O17_RS07965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H2O17_RS07970	COG2137	regulation of response to DNA damage stimulus
H2O17_RS07975	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H2O17_RS07985	COG1396	sequence-specific DNA binding
H2O17_RS07990	COG1058	Belongs to the CinA family
H2O17_RS07990	COG1546	Belongs to the CinA family
H2O17_RS08005	COG1674	ftsk spoiiie
H2O17_RS08015	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H2O17_RS08020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2O17_RS08030	COG0205	6-phosphofructokinase activity
H2O17_RS08035	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H2O17_RS08040	COG0612	Peptidase, M16
H2O17_RS08045	COG1185	polyribonucleotide nucleotidyltransferase activity
H2O17_RS08050	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H2O17_RS08065	COG2721	sulfolactate sulfo-lyase activity
H2O17_RS08070	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H2O17_RS08075	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H2O17_RS08080	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H2O17_RS08080	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H2O17_RS08095	COG0779	Required for maturation of 30S ribosomal subunits
H2O17_RS08130	COG0442	prolyl-tRNA aminoacylation
H2O17_RS08140	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H2O17_RS08145	COG0750	zinc metalloprotease
H2O17_RS08150	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H2O17_RS08160	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H2O17_RS08170	COG0233	cytoplasmic translational termination
H2O17_RS08180	COG3830	Belongs to the UPF0237 family
H2O17_RS08185	COG2848	UPF0210 protein
H2O17_RS08190	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H2O17_RS08195	COG0052	Belongs to the universal ribosomal protein uS2 family
H2O17_RS08205	COG4974	Belongs to the 'phage' integrase family
H2O17_RS08230	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H2O17_RS08235	COG0681	Belongs to the peptidase S26 family
H2O17_RS08240	COG0335	large ribosomal subunit rRNA binding
H2O17_RS08245	COG0336	Belongs to the RNA methyltransferase TrmD family
H2O17_RS08250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H2O17_RS08255	COG1837	Belongs to the UPF0109 family
H2O17_RS08260	COG0228	four-way junction DNA binding
H2O17_RS08265	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H2O17_RS08280	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H2O17_RS08310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2O17_RS08315	COG1461	Dihydroxyacetone kinase
H2O17_RS08320	COG2376	Dihydroxyacetone kinase
H2O17_RS08325	COG0105	UTP biosynthetic process
H2O17_RS08330	COG0285	dihydrofolate synthase activity
H2O17_RS08345	COG2723	6-phospho-beta-galactosidase activity
H2O17_RS08350	COG0395	ABC-type sugar transport system, permease component
H2O17_RS08355	COG1175	transmembrane transport
H2O17_RS08370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H2O17_RS08385	COG0823	Involved in the tonB-independent uptake of proteins
H2O17_RS08385	COG1506	peptidase
H2O17_RS08390	COG1022	Amp-dependent synthetase and ligase
H2O17_RS08395	COG1605	Chorismate mutase
H2O17_RS08395	COG0287	Prephenate dehydrogenase
H2O17_RS08400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H2O17_RS08405	COG0740	serine-type endopeptidase activity
H2O17_RS08410	COG0740	serine-type endopeptidase activity
H2O17_RS08415	COG0544	peptidyl-prolyl cis-trans isomerase activity
H2O17_RS08465	COG1309	transcriptional regulator
H2O17_RS08470	COG2409	Drug exporters of the RND superfamily
H2O17_RS08485	COG1739	Uncharacterized protein family UPF0029
H2O17_RS08495	COG1045	serine acetyltransferase
H2O17_RS08500	COG0698	ribose 5-phosphate isomerase
H2O17_RS08505	COG3590	peptidase
H2O17_RS08515	COG1263	PTS System
H2O17_RS08515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2O17_RS08515	COG2190	(PTS) system
H2O17_RS08520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2O17_RS08530	COG1946	Acyl-CoA thioesterase
H2O17_RS08585	COG1254	Belongs to the acylphosphatase family
H2O17_RS08595	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H2O17_RS08600	COG0477	Major facilitator Superfamily
H2O17_RS08610	COG1122	ATPase activity
H2O17_RS08615	COG1268	BioY protein
H2O17_RS08635	COG0765	amino acid transport
H2O17_RS08640	COG1126	abc transporter atp-binding protein
H2O17_RS08660	COG0148	phosphopyruvate hydratase activity
H2O17_RS08665	COG2910	NAD(P)H-binding
H2O17_RS08670	COG1733	regulation of RNA biosynthetic process
H2O17_RS08675	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H2O17_RS08685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2O17_RS08705	COG0604	alcohol dehydrogenase
H2O17_RS08770	COG1937	Protein conserved in bacteria
H2O17_RS08780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H2O17_RS08860	COG0629	single-stranded DNA binding
H2O17_RS08900	COG2985	domain, Protein
H2O17_RS08900	COG0569	domain protein
H2O17_RS08935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H2O17_RS08940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H2O17_RS08945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H2O17_RS08950	COG0473	3-isopropylmalate dehydrogenase activity
H2O17_RS08955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H2O17_RS08970	COG1136	(ABC) transporter
H2O17_RS08985	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H2O17_RS08990	COG0440	acetolactate synthase activity
H2O17_RS08995	COG0028	Belongs to the TPP enzyme family
H2O17_RS09010	COG0569	domain protein
H2O17_RS09010	COG2985	domain, Protein
H2O17_RS09015	COG0129	dihydroxy-acid dehydratase activity
H2O17_RS09020	COG1132	(ABC) transporter
H2O17_RS09025	COG4988	ABC transporter
H2O17_RS09030	COG1120	ATPase activity
H2O17_RS09035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2O17_RS09060	COG3459	Glycosyltransferase 36 associated
H2O17_RS09075	COG2353	YceI-like domain
H2O17_RS09100	COG1609	Transcriptional regulator
H2O17_RS09140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H2O17_RS09145	COG0154	amidase activity
H2O17_RS09150	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H2O17_RS09155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2O17_RS09160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H2O17_RS09190	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H2O17_RS09210	COG2514	catechol 2,3-dioxygenase activity
H2O17_RS09215	COG1132	(ABC) transporter
H2O17_RS09225	COG1309	transcriptional regulator
H2O17_RS09230	COG0114	fumarate hydratase activity
H2O17_RS09245	COG0505	Belongs to the CarA family
H2O17_RS09255	COG0676	glucose-6-phosphate 1-epimerase activity
H2O17_RS09260	COG1454	alcohol dehydrogenase
H2O17_RS09265	COG1309	transcriptional regulator
H2O17_RS09285	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H2O17_RS09290	COG1472	Belongs to the glycosyl hydrolase 3 family
H2O17_RS09300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H2O17_RS09320	COG1615	UPF0182 protein
H2O17_RS09330	COG3480	Lon protease (S16) C-terminal proteolytic domain
H2O17_RS09360	COG0180	Tryptophanyl-tRNA synthetase
H2O17_RS09370	COG0402	S-adenosylhomocysteine deaminase activity
H2O17_RS09385	COG0366	Alpha amylase catalytic
H2O17_RS09395	COG3281	Trehalose synthase
H2O17_RS09400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H2O17_RS09440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H2O17_RS09445	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
H2O17_RS09455	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H2O17_RS09460	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H2O17_RS09465	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H2O17_RS09470	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H2O17_RS09475	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H2O17_RS09480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H2O17_RS09485	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H2O17_RS09490	COG0356	it plays a direct role in the translocation of protons across the membrane
H2O17_RS09500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H2O17_RS09515	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H2O17_RS09530	COG0083	homoserine kinase activity
H2O17_RS09535	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H2O17_RS09540	COG0460	homoserine dehydrogenase
H2O17_RS09545	COG0710	3-dehydroquinate dehydratase activity
H2O17_RS09555	COG0018	arginyl-trna synthetase
H2O17_RS09565	COG3012	SEC-C Motif Domain Protein
H2O17_RS09570	COG0584	glycerophosphoryl diester phosphodiesterase
H2O17_RS09575	COG0741	lytic transglycosylase activity
H2O17_RS09575	COG1196	nuclear chromosome segregation
H2O17_RS09575	COG0739	heme binding
H2O17_RS09585	COG1253	flavin adenine dinucleotide binding
H2O17_RS09590	COG0567	Dehydrogenase, E1 component
H2O17_RS09590	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2O17_RS09620	COG1595	DNA-templated transcription, initiation
H2O17_RS09630	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H2O17_RS09635	COG1162	GTPase activity
H2O17_RS09640	COG0483	inositol monophosphate 1-phosphatase activity
H2O17_RS09645	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H2O17_RS09650	COG0420	3'-5' exonuclease activity
H2O17_RS09655	COG0419	ATPase involved in DNA repair
H2O17_RS09670	COG0653	protein targeting
H2O17_RS09680	COG1007	ATP synthesis coupled electron transport
H2O17_RS09690	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H2O17_RS09695	COG0713	ATP synthesis coupled electron transport
H2O17_RS09700	COG0839	Belongs to the complex I subunit 6 family
H2O17_RS09705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2O17_RS09710	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H2O17_RS09715	COG1034	ATP synthesis coupled electron transport
H2O17_RS09720	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H2O17_RS09730	COG0649	NAD binding
H2O17_RS09735	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2O17_RS09740	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2O17_RS09750	COG0644	oxidoreductase
H2O17_RS09755	COG2226	methyltransferase
H2O17_RS09760	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H2O17_RS09780	COG0406	alpha-ribazole phosphatase activity
H2O17_RS09800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H2O17_RS09810	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H2O17_RS09820	COG1194	a g-specific adenine glycosylase
H2O17_RS09830	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H2O17_RS09840	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H2O17_RS09850	COG0247	lactate metabolic process
H2O17_RS09855	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H2O17_RS09860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H2O17_RS09865	COG1620	l-lactate permease
H2O17_RS09870	COG0247	lactate metabolic process
H2O17_RS09875	COG1139	Iron-sulfur cluster binding protein
H2O17_RS09880	COG1556	Lactate utilization protein
H2O17_RS09895	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H2O17_RS09900	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H2O17_RS09905	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H2O17_RS09915	COG0386	Belongs to the glutathione peroxidase family
H2O17_RS09940	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H2O17_RS09945	COG0302	gtp cyclohydrolase
H2O17_RS09950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H2O17_RS09960	COG0037	tRNA processing
H2O17_RS09975	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H2O17_RS09985	COG2873	o-acetylhomoserine
H2O17_RS09990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2O17_RS10005	COG0277	FAD linked oxidase domain protein
H2O17_RS10005	COG0247	lactate metabolic process
H2O17_RS10020	COG0574	Belongs to the PEP-utilizing enzyme family
H2O17_RS10020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H2O17_RS10030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H2O17_RS10035	COG1609	Transcriptional regulator
H2O17_RS10045	COG2160	L-arabinose isomerase activity
H2O17_RS10070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2O17_RS10075	COG1063	alcohol dehydrogenase
H2O17_RS10080	COG2211	Major facilitator Superfamily
H2O17_RS10085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H2O17_RS10090	COG3959	Transketolase, thiamine diphosphate binding domain
H2O17_RS10100	COG1609	Transcriptional regulator
H2O17_RS10125	COG3507	Belongs to the glycosyl hydrolase 43 family
H2O17_RS10140	COG1175	transmembrane transport
H2O17_RS10145	COG0395	ABC-type sugar transport system, permease component
H2O17_RS10160	COG3458	cephalosporin-C deacetylase activity
H2O17_RS10185	COG1172	Belongs to the binding-protein-dependent transport system permease family
H2O17_RS10190	COG1129	ABC transporter
H2O17_RS10200	COG0025	NhaP-type Na H and K H
H2O17_RS10230	COG1070	Carbohydrate kinase
H2O17_RS10240	COG2017	converts alpha-aldose to the beta-anomer
H2O17_RS10250	COG0149	triose-phosphate isomerase activity
H2O17_RS10255	COG2376	Dihydroxyacetone kinase
H2O17_RS10265	COG1028	Short-chain dehydrogenase reductase Sdr
H2O17_RS10270	COG2271	Major facilitator Superfamily
H2O17_RS10290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2O17_RS10300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H2O17_RS10310	COG1490	D-aminoacyl-tRNA deacylase activity
H2O17_RS10325	COG3485	protocatechuate 3,4-dioxygenase
H2O17_RS10335	COG0745	RESPONSE REGULATOR receiver
H2O17_RS10345	COG0306	phosphate transporter
H2O17_RS10350	COG0025	NhaP-type Na H and K H
H2O17_RS10375	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H2O17_RS10405	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H2O17_RS10425	COG2205	protein histidine kinase activity
H2O17_RS10430	COG0745	RESPONSE REGULATOR receiver
H2O17_RS10435	COG5006	permease, DMT superfamily
H2O17_RS10445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H2O17_RS10515	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H2O17_RS10530	COG0737	Belongs to the 5'-nucleotidase family
H2O17_RS10530	COG1525	nuclease
H2O17_RS10530	COG4085	toxin activity
H2O17_RS10535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H2O17_RS10540	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H2O17_RS10545	COG0047	phosphoribosylformylglycinamidine synthase activity
H2O17_RS10555	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H2O17_RS10560	COG0151	Belongs to the GarS family
H2O17_RS10570	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H2O17_RS10580	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H2O17_RS10585	COG0058	SHG alpha-glucan phosphorylase activity
H2O17_RS10610	COG0191	fructose-bisphosphate aldolase activity
H2O17_RS10625	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H2O17_RS10630	COG0577	efflux transmembrane transporter activity
H2O17_RS10630	COG1136	(ABC) transporter
H2O17_RS10640	COG1136	(ABC) transporter
H2O17_RS10670	COG4221	oxidoreductase activity
H2O17_RS10675	COG0708	Exodeoxyribonuclease III
H2O17_RS10695	COG1115	amino acid carrier protein
H2O17_RS10710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H2O17_RS10725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H2O17_RS10755	COG2807	transmembrane transport
H2O17_RS10770	COG0443	Heat shock 70 kDa protein
H2O17_RS10775	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H2O17_RS10780	COG0484	heat shock protein binding
H2O17_RS10785	COG0789	Transcriptional regulator
H2O17_RS10795	COG3842	ATPase activity
H2O17_RS10800	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H2O17_RS10820	COG2212	antiporter activity
H2O17_RS10840	COG2111	Na H antiporter
H2O17_RS10840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H2O17_RS10845	COG0717	Belongs to the dCTP deaminase family
H2O17_RS10850	COG4948	Mandelate Racemase Muconate Lactonizing
H2O17_RS10855	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H2O17_RS10865	COG1169	isochorismate synthase
H2O17_RS10890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H2O17_RS10900	COG1950	PFAM Membrane protein of
H2O17_RS10905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H2O17_RS10910	COG0586	Pfam SNARE associated Golgi protein
H2O17_RS10930	COG2233	PERMEase
H2O17_RS10935	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H2O17_RS10940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H2O17_RS10955	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H2O17_RS10970	COG2186	Transcriptional regulator
H2O17_RS10975	COG1929	Belongs to the glycerate kinase type-1 family
H2O17_RS10980	COG4948	Mandelate Racemase Muconate Lactonizing
H2O17_RS10985	COG2084	Dehydrogenase
H2O17_RS10990	COG2610	gluconate transmembrane transporter activity
H2O17_RS11000	COG1414	Transcriptional regulator
H2O17_RS11010	COG2860	membrane
H2O17_RS11030	COG1643	Atp-dependent helicase
H2O17_RS11040	COG1201	RNA secondary structure unwinding
H2O17_RS11065	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H2O17_RS11075	COG0444	Belongs to the ABC transporter superfamily
H2O17_RS11090	COG0747	negative chemotaxis
H2O17_RS11095	COG1228	amidohydrolase
H2O17_RS11125	COG2072	flavoprotein involved in K transport
H2O17_RS11130	COG0640	Transcriptional regulator
H2O17_RS11155	COG0747	negative chemotaxis
H2O17_RS11165	COG0444	Belongs to the ABC transporter superfamily
H2O17_RS11170	COG4608	Belongs to the ABC transporter superfamily
H2O17_RS11175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2O17_RS11180	COG1940	carbohydrate kinase activity
H2O17_RS11185	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H2O17_RS11190	COG1175	transmembrane transport
H2O17_RS11195	COG0395	ABC-type sugar transport system, permease component
H2O17_RS11200	COG1653	transport
H2O17_RS11215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H2O17_RS11225	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H2O17_RS11235	COG0471	metal ion transport
H2O17_RS11240	COG3852	Histidine kinase
H2O17_RS11265	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H2O17_RS11270	COG1780	Probably involved in ribonucleotide reductase function
H2O17_RS11280	COG1760	l-serine dehydratase
H2O17_RS11305	COG1904	glucuronate isomerase
H2O17_RS11315	COG2211	Major facilitator Superfamily
H2O17_RS11320	COG0359	binds to the 23S rRNA
H2O17_RS11325	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H2O17_RS11335	COG0360	Binds together with S18 to 16S ribosomal RNA
H2O17_RS11340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H2O17_RS11345	COG0628	permease
H2O17_RS11355	COG1260	myo-inositol-1-phosphate synthase
H2O17_RS11365	COG0617	tRNA 3'-terminal CCA addition
H2O17_RS11395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2O17_RS11410	COG1192	Involved in chromosome partitioning
H2O17_RS11420	COG0357	Ribosomal RNA small subunit methyltransferase G
H2O17_RS11430	COG0706	membrane insertase activity
H2O17_RS11440	COG0594	ribonuclease P activity
H2O17_RS11445	COG0230	Belongs to the bacterial ribosomal protein bL34 family