locus-tag	class	description
AF_RS00010	COG4604	ABC transporter, ATP-binding protein
AF_RS00020	COG5012	cobalamin binding
AF_RS00035	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
AF_RS00045	COG5012	cobalamin binding
AF_RS00075	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_RS00080	COG0183	Belongs to the thiolase family
AF_RS00095	COG3290	protein histidine kinase activity
AF_RS00105	COG2414	aldehyde ferredoxin oxidoreductase
AF_RS00125	COG4274	PFAM GYD family protein
AF_RS00150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AF_RS00155	COG0183	Belongs to the thiolase family
AF_RS00165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AF_RS00170	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AF_RS00175	COG0438	transferase activity, transferring glycosyl groups
AF_RS00180	COG1216	Glycosyl transferase, family 2
AF_RS00200	COG0438	transferase activity, transferring glycosyl groups
AF_RS00240	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
AF_RS00245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AF_RS00290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AF_RS00295	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AF_RS00360	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AF_RS00360	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AF_RS00370	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AF_RS00390	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AF_RS00425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AF_RS00435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AF_RS00435	COG1116	anion transmembrane transporter activity
AF_RS00440	COG0318	PFAM AMP-dependent synthetase and ligase
AF_RS00455	COG3842	ATPase activity
AF_RS00460	COG4149	molybdate abc transporter
AF_RS00465	COG0725	ABC transporter, periplasmic molybdate-binding protein
AF_RS00520	COG0540	Belongs to the ATCase OTCase family
AF_RS00525	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AF_RS00530	COG1830	Aldolase
AF_RS00540	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AF_RS00550	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AF_RS00565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AF_RS00690	COG2226	methyltransferase
AF_RS00760	COG0672	)-iron permease
AF_RS00775	COG0437	4 iron, 4 sulfur cluster binding
AF_RS00810	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AF_RS00820	COG1141	Ferredoxin
AF_RS00875	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AF_RS00925	COG0822	iron-sulfur transferase activity
AF_RS00930	COG1104	cysteine desulfurase activity
AF_RS00940	COG0425	Belongs to the sulfur carrier protein TusA family
AF_RS00975	COG0318	PFAM AMP-dependent synthetase and ligase
AF_RS00980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AF_RS00985	COG2030	dehydratase
AF_RS00985	COG1012	belongs to the aldehyde dehydrogenase family
AF_RS00995	COG1022	Amp-dependent synthetase and ligase
AF_RS01020	COG2264	protein methyltransferase activity
AF_RS01040	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AF_RS01050	COG2239	Acts as a magnesium transporter
AF_RS01055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AF_RS01075	COG2264	protein methyltransferase activity
AF_RS01080	COG0475	glutathione-regulated potassium exporter activity
AF_RS01080	COG0569	domain protein
AF_RS01090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AF_RS01095	COG0439	Biotin carboxylase
AF_RS01130	COG1605	Chorismate mutase
AF_RS01130	COG0077	Prephenate dehydratase
AF_RS01135	COG0710	3-dehydroquinate dehydratase activity
AF_RS01140	COG1465	3-dehydroquinate synthase
AF_RS01145	COG1830	Aldolase
AF_RS01150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AF_RS01155	COG0765	amino acid transport
AF_RS01165	COG0501	Belongs to the peptidase M48B family
AF_RS01175	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AF_RS01180	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AF_RS01185	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AF_RS01195	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AF_RS01215	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AF_RS01215	COG1918	ferrous iron import across plasma membrane
AF_RS01245	COG2835	tetraacyldisaccharide 4'-kinase activity
AF_RS01250	COG0504	CTP synthase activity
AF_RS01255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AF_RS01255	COG0519	Catalyzes the synthesis of GMP from XMP
AF_RS01260	COG0446	pyridine nucleotide-disulphide oxidoreductase
AF_RS01315	COG0318	PFAM AMP-dependent synthetase and ligase
AF_RS01325	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AF_RS01325	COG1213	nucleotidyl transferase
AF_RS01355	COG0450	alkyl hydroperoxide reductase
AF_RS01385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AF_RS01395	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AF_RS01415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AF_RS01430	COG0183	Belongs to the thiolase family
AF_RS01440	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_RS01450	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AF_RS01580	COG0438	transferase activity, transferring glycosyl groups
AF_RS01580	COG1216	Glycosyl transferase, family 2
AF_RS01640	COG1216	Glycosyl transferase, family 2
AF_RS01640	COG1442	glycosyl transferase family 8
AF_RS01650	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AF_RS01655	COG1091	dTDP-4-dehydrorhamnose reductase activity
AF_RS01660	COG1088	dTDP-glucose 4,6-dehydratase activity
AF_RS01675	COG0438	transferase activity, transferring glycosyl groups
AF_RS01680	COG1216	Glycosyl transferase, family 2
AF_RS01735	COG1454	alcohol dehydrogenase
AF_RS01755	COG0655	NAD(P)H dehydrogenase (quinone) activity
AF_RS01760	COG2033	superoxide reductase activity
AF_RS01770	COG2217	Heavy metal translocating P-type atpase
AF_RS01820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AF_RS01825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AF_RS01835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AF_RS01865	COG0470	DNA polymerase III
AF_RS01865	COG1067	ATP-dependent peptidase activity
AF_RS01875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AF_RS01880	COG2223	nitrite transmembrane transporter activity
AF_RS01890	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AF_RS01895	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
AF_RS01900	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AF_RS01910	COG0647	UMP catabolic process
AF_RS01965	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AF_RS01975	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AF_RS01985	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AF_RS02000	COG1131	(ABC) transporter
AF_RS02005	COG0277	FAD linked oxidase domain protein
AF_RS02010	COG0446	pyridine nucleotide-disulphide oxidoreductase
AF_RS02040	COG0446	pyridine nucleotide-disulphide oxidoreductase
AF_RS02050	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AF_RS02085	COG0436	Aminotransferase
AF_RS02090	COG4191	Histidine kinase
AF_RS02095	COG0215	cysteine-tRNA ligase activity
AF_RS02135	COG0434	BtpA family
AF_RS02150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AF_RS02150	COG1648	precorrin-2 dehydrogenase activity
AF_RS02155	COG2221	Nitrite and sulphite reductase 4Fe-4S
AF_RS02160	COG2221	Nitrite and sulphite reductase 4Fe-4S
AF_RS02175	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AF_RS02190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AF_RS02205	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_RS02210	COG1024	Enoyl-CoA hydratase
AF_RS02215	COG1960	acyl-CoA dehydrogenase activity
AF_RS02225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AF_RS02235	COG0720	synthase
AF_RS02240	COG0602	queuosine metabolic process
AF_RS02245	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AF_RS02270	COG5002	protein histidine kinase activity
AF_RS02275	COG2201	protein-glutamate methylesterase activity
AF_RS02280	COG3290	protein histidine kinase activity
AF_RS02290	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AF_RS02305	COG1902	pentaerythritol trinitrate reductase activity
AF_RS02305	COG0446	pyridine nucleotide-disulphide oxidoreductase
AF_RS02320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AF_RS02325	COG2409	Drug exporters of the RND superfamily
AF_RS02365	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AF_RS02380	COG2358	TRAP transporter, solute receptor (TAXI family
AF_RS02385	COG1013	pyruvate-flavodoxin oxidoreductase activity
AF_RS02390	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AF_RS02390	COG0674	pyruvate-flavodoxin oxidoreductase activity
AF_RS02410	COG2217	Heavy metal translocating P-type atpase
AF_RS02415	COG1522	sequence-specific DNA binding
AF_RS02420	COG0798	PFAM Bile acid sodium symporter
AF_RS02430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AF_RS02435	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AF_RS02450	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AF_RS02455	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AF_RS02465	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AF_RS02465	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AF_RS02505	COG1185	polyribonucleotide nucleotidyltransferase activity
AF_RS02510	COG1185	polyribonucleotide nucleotidyltransferase activity
AF_RS02515	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AF_RS02530	COG0417	DNA replication proofreading
AF_RS02575	COG2181	nitrate reductase activity
AF_RS02575	COG0247	lactate metabolic process
AF_RS02585	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AF_RS02590	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AF_RS02605	COG2226	methyltransferase
AF_RS02655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AF_RS02680	COG1185	polyribonucleotide nucleotidyltransferase activity
AF_RS02685	COG0543	2 iron, 2 sulfur cluster binding
AF_RS02700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AF_RS02720	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AF_RS02735	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AF_RS02765	COG0247	lactate metabolic process
AF_RS02780	COG0247	lactate metabolic process
AF_RS02795	COG0402	S-adenosylhomocysteine deaminase activity
AF_RS02800	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AF_RS02805	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AF_RS02810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AF_RS02825	COG0425	Belongs to the sulfur carrier protein TusA family
AF_RS02830	COG0446	pyridine nucleotide-disulphide oxidoreductase
AF_RS02840	COG0482	sulfurtransferase activity
AF_RS02865	COG1104	cysteine desulfurase activity
AF_RS02870	COG0822	iron-sulfur transferase activity
AF_RS02895	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AF_RS02920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AF_RS02950	COG0463	Glycosyl transferase, family 2
AF_RS02985	COG0343	queuine tRNA-ribosyltransferase activity
AF_RS02990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AF_RS02995	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AF_RS03005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AF_RS03025	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AF_RS03140	COG0297	glycogen (starch) synthase activity
AF_RS03165	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AF_RS03175	COG1793	dna ligase
AF_RS03200	COG0473	3-isopropylmalate dehydrogenase activity
AF_RS03205	COG0066	3-isopropylmalate dehydratase activity
AF_RS03220	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AF_RS03225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AF_RS03235	COG2358	TRAP transporter, solute receptor (TAXI family
AF_RS03255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AF_RS03260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AF_RS03260	COG1116	anion transmembrane transporter activity
AF_RS03285	COG0010	Belongs to the arginase family
AF_RS03290	COG0538	isocitrate dehydrogenase activity
AF_RS03325	COG0446	pyridine nucleotide-disulphide oxidoreductase
AF_RS03330	COG0312	modulator of DNA gyrase
AF_RS03355	COG1694	Mazg nucleotide pyrophosphohydrolase
AF_RS03365	COG1053	succinate dehydrogenase
AF_RS03365	COG0431	NADPH-dependent FMN reductase
AF_RS03365	COG3976	FMN-binding domain protein
AF_RS03370	COG1233	COG1233 Phytoene dehydrogenase and related
AF_RS03380	COG0515	serine threonine protein kinase
AF_RS03380	COG2815	serine threonine protein kinase
AF_RS03400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AF_RS03405	COG1960	acyl-CoA dehydrogenase activity
AF_RS03410	COG0318	PFAM AMP-dependent synthetase and ligase
AF_RS03430	COG0563	adenylate kinase activity
AF_RS03435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AF_RS03455	COG1053	succinate dehydrogenase
AF_RS03480	COG1024	Enoyl-CoA hydratase
AF_RS03490	COG0318	PFAM AMP-dependent synthetase and ligase
AF_RS03510	COG2871	sodium ion transport
AF_RS03540	COG2894	cell division
AF_RS03565	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
AF_RS03590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AF_RS03605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AF_RS03605	COG0574	Belongs to the PEP-utilizing enzyme family
AF_RS03620	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AF_RS03665	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AF_RS03690	COG0310	cobalt ion transport
AF_RS03705	COG1122	ATPase activity
AF_RS03715	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AF_RS03735	COG2104	thiamine diphosphate biosynthetic process
AF_RS03755	COG0432	Pfam Uncharacterised protein family UPF0047
AF_RS03765	COG0864	Transcriptional regulator
AF_RS03775	COG0167	dihydroorotate dehydrogenase activity
AF_RS03785	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AF_RS03800	COG1013	pyruvate-flavodoxin oxidoreductase activity
AF_RS03825	COG2181	nitrate reductase activity
AF_RS03825	COG0247	lactate metabolic process
AF_RS03830	COG1227	inorganic diphosphatase activity
AF_RS03885	COG0105	UTP biosynthetic process
AF_RS03890	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AF_RS03930	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AF_RS03955	COG0009	L-threonylcarbamoyladenylate synthase
AF_RS03970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AF_RS03980	COG0598	Magnesium transport protein CorA
AF_RS03995	COG0697	spore germination
AF_RS04040	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AF_RS04045	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AF_RS04055	COG0019	diaminopimelate decarboxylase activity
AF_RS04085	COG1620	l-lactate permease
AF_RS04095	COG0277	FAD linked oxidase domain protein
AF_RS04115	COG1139	Iron-sulfur cluster binding protein
AF_RS04130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AF_RS04140	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
AF_RS04155	COG1254	Belongs to the acylphosphatase family
AF_RS04160	COG0107	imidazoleglycerol-phosphate synthase activity
AF_RS04215	COG1773	rubredoxin
AF_RS04215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AF_RS04220	COG1592	Rubrerythrin
AF_RS04230	COG2033	superoxide reductase activity
AF_RS04250	COG0569	domain protein
AF_RS04260	COG0318	PFAM AMP-dependent synthetase and ligase
AF_RS04265	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AF_RS04285	COG1960	acyl-CoA dehydrogenase activity
AF_RS04295	COG0517	IMP dehydrogenase activity
AF_RS04295	COG1125	glycine betaine transport
AF_RS04300	COG0517	IMP dehydrogenase activity
AF_RS04320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AF_RS04325	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AF_RS04325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AF_RS04335	COG0039	L-malate dehydrogenase activity
AF_RS04385	COG0596	Alpha beta hydrolase
AF_RS04400	COG0277	FAD linked oxidase domain protein
AF_RS04405	COG0393	Putative heavy-metal-binding
AF_RS04410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AF_RS04420	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AF_RS04440	COG0737	Belongs to the 5'-nucleotidase family
AF_RS04440	COG1525	nuclease
AF_RS04440	COG4085	toxin activity
AF_RS04460	COG1773	rubredoxin
AF_RS04470	COG2205	protein histidine kinase activity
AF_RS04475	COG0252	asparaginase activity
AF_RS04480	COG0165	Argininosuccinate lyase
AF_RS04500	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AF_RS04505	COG3845	ABC transporter
AF_RS04510	COG4603	Belongs to the binding-protein-dependent transport system permease family
AF_RS04515	COG1079	Belongs to the binding-protein-dependent transport system permease family
AF_RS04535	COG3290	protein histidine kinase activity
AF_RS04585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AF_RS04600	COG2271	Major facilitator Superfamily
AF_RS04610	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AF_RS04615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AF_RS04635	COG0023	Translation Initiation Factor
AF_RS04645	COG0423	glycine-tRNA ligase activity
AF_RS04650	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AF_RS04665	COG0017	Asparaginyl-tRNA synthetase
AF_RS04700	COG0546	phosphoglycolate phosphatase activity
AF_RS04705	COG0284	orotidine-5'-phosphate decarboxylase activity
AF_RS04710	COG0303	'Molybdopterin
AF_RS04715	COG0303	'Molybdopterin
AF_RS04725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AF_RS04735	COG0460	homoserine dehydrogenase
AF_RS04745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AF_RS04750	COG0051	transcription antitermination factor activity, RNA binding
AF_RS04755	COG1234	tRNA 3'-trailer cleavage
AF_RS04770	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AF_RS04775	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AF_RS04805	COG0174	glutamine synthetase
AF_RS04815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AF_RS04820	COG0067	glutamate synthase
AF_RS04845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AF_RS04855	COG1137	ATPase activity
AF_RS04875	COG1024	Enoyl-CoA hydratase
AF_RS04905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AF_RS04920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AF_RS04925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AF_RS04930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AF_RS04935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AF_RS04940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AF_RS04945	COG0004	ammonium transporteR
AF_RS04960	COG1174	glycine betaine transport
AF_RS04965	COG1125	glycine betaine transport
AF_RS04965	COG0517	IMP dehydrogenase activity
AF_RS04985	COG4555	ABC transporter
AF_RS04990	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AF_RS04990	COG0131	Imidazoleglycerol-phosphate dehydratase
AF_RS04995	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AF_RS05035	COG1418	mRNA catabolic process
AF_RS05050	COG0402	S-adenosylhomocysteine deaminase activity
AF_RS05065	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AF_RS05090	COG0842	Transport permease protein
AF_RS05095	COG1131	(ABC) transporter
AF_RS05140	COG0129	dihydroxy-acid dehydratase activity
AF_RS05155	COG0577	efflux transmembrane transporter activity
AF_RS05160	COG1136	(ABC) transporter
AF_RS05175	COG1131	(ABC) transporter
AF_RS05185	COG0644	oxidoreductase
AF_RS05190	COG1110	DNA topoisomerase II activity
AF_RS05195	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_RS05200	COG1960	acyl-CoA dehydrogenase activity
AF_RS05210	COG0183	Belongs to the thiolase family
AF_RS05215	COG0318	PFAM AMP-dependent synthetase and ligase
AF_RS05220	COG0433	COG0433 Predicted ATPase
AF_RS05230	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AF_RS05240	COG3290	protein histidine kinase activity
AF_RS05240	COG0840	transmembrane signaling receptor activity
AF_RS05260	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AF_RS05265	COG1776	CheC inhibitor of MCP methylation
AF_RS05270	COG0643	Histidine kinase
AF_RS05270	COG2198	Histidine kinase
AF_RS05275	COG2201	protein-glutamate methylesterase activity
AF_RS05280	COG2201	protein-glutamate methylesterase activity
AF_RS05290	COG0835	chemotaxis
AF_RS05295	COG0840	transmembrane signaling receptor activity
AF_RS05295	COG3290	protein histidine kinase activity
AF_RS05390	COG2201	protein-glutamate methylesterase activity
AF_RS05395	COG1121	(ABC) transporter
AF_RS05420	COG4145	pantothenate transmembrane transporter activity
AF_RS05435	COG1598	PFAM Uncharacterised protein family UPF0150
AF_RS05620	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AF_RS05645	COG1185	polyribonucleotide nucleotidyltransferase activity
AF_RS05670	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_RS05690	COG0535	radical SAM domain protein
AF_RS05705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AF_RS05710	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AF_RS05725	COG0148	phosphopyruvate hydratase activity
AF_RS05730	COG0052	Belongs to the universal ribosomal protein uS2 family
AF_RS05760	COG1131	(ABC) transporter
AF_RS05775	COG1213	nucleotidyl transferase
AF_RS05790	COG0427	acetyl-CoA hydrolase
AF_RS05795	COG0126	phosphoglycerate kinase activity
AF_RS05800	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AF_RS05805	COG1522	sequence-specific DNA binding
AF_RS05810	COG1201	RNA secondary structure unwinding
AF_RS05860	COG0151	Belongs to the GarS family
AF_RS05870	COG1269	ATP hydrolysis coupled proton transport
AF_RS05895	COG1527	subunit (C
AF_RS05905	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AF_RS05910	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
AF_RS05915	COG1394	ATPase activity, coupled to movement of substances
AF_RS05920	COG1268	BioY protein
AF_RS05925	COG1122	ATPase activity
AF_RS05950	COG1960	acyl-CoA dehydrogenase activity
AF_RS05960	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_RS05985	COG1160	GTP binding
AF_RS06000	COG4191	Histidine kinase
AF_RS06010	COG0517	IMP dehydrogenase activity
AF_RS06010	COG0516	GMP reductase activity
AF_RS06030	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_RS06035	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AF_RS06055	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AF_RS06060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AF_RS06065	COG0183	Belongs to the thiolase family
AF_RS06105	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_RS06110	COG1028	Short-chain dehydrogenase reductase Sdr
AF_RS06125	COG3246	L-lysine catabolic process to acetate
AF_RS06135	COG0857	belongs to the CobB CobQ family
AF_RS06150	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AF_RS06155	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AF_RS06170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AF_RS06190	COG1418	mRNA catabolic process
AF_RS06215	COG2409	Drug exporters of the RND superfamily
AF_RS06225	COG1378	Sugar-specific transcriptional regulator TrmB
AF_RS06265	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AF_RS06270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AF_RS06275	COG0181	hydroxymethylbilane synthase activity
AF_RS06280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AF_RS06290	COG0475	glutathione-regulated potassium exporter activity
AF_RS06300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AF_RS06305	COG1811	Na channel or pump
AF_RS06340	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AF_RS06345	COG2201	protein-glutamate methylesterase activity
AF_RS06350	COG0116	Belongs to the methyltransferase superfamily
AF_RS06360	COG0517	IMP dehydrogenase activity
AF_RS06360	COG1125	glycine betaine transport
AF_RS06365	COG0047	phosphoribosylformylglycinamidine synthase activity
AF_RS06370	COG0318	PFAM AMP-dependent synthetase and ligase
AF_RS06375	COG0446	pyridine nucleotide-disulphide oxidoreductase
AF_RS06375	COG1902	pentaerythritol trinitrate reductase activity
AF_RS06390	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AF_RS06405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AF_RS06415	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AF_RS06420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AF_RS06425	COG0505	Belongs to the CarA family
AF_RS06430	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AF_RS06435	COG1691	(AIR) carboxylase
AF_RS06445	COG0505	Belongs to the CarA family
AF_RS06460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AF_RS06470	COG0693	protein deglycase activity
AF_RS06490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AF_RS06500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AF_RS06505	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AF_RS06505	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AF_RS06525	COG0183	Belongs to the thiolase family
AF_RS06535	COG1960	acyl-CoA dehydrogenase activity
AF_RS06560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AF_RS06575	COG1131	(ABC) transporter
AF_RS06585	COG0149	triose-phosphate isomerase activity
AF_RS06590	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
AF_RS06605	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AF_RS06610	COG0170	dolichyl monophosphate biosynthetic process
AF_RS06620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AF_RS06640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AF_RS06645	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AF_RS06670	COG0519	Catalyzes the synthesis of GMP from XMP
AF_RS06670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AF_RS06675	COG0037	tRNA processing
AF_RS06700	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AF_RS06710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AF_RS06750	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AF_RS06760	COG1492	cobalamin metabolic process
AF_RS06765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AF_RS06770	COG0372	Belongs to the citrate synthase family
AF_RS06785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AF_RS06790	COG0805	protein transport
AF_RS06810	COG1773	rubredoxin
AF_RS06815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AF_RS06835	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AF_RS06835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AF_RS06845	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AF_RS06850	COG0573	inorganic phosphate transmembrane transporter activity
AF_RS06855	COG0581	inorganic phosphate transmembrane transporter activity
AF_RS06860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AF_RS06865	COG0704	Plays a role in the regulation of phosphate uptake
AF_RS06885	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AF_RS06895	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AF_RS06900	COG0375	protein maturation
AF_RS06915	COG0409	Hydrogenase expression formation protein
AF_RS06925	COG3259	Nickel-dependent hydrogenase
AF_RS06930	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
AF_RS06955	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AF_RS06970	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AF_RS06985	COG2201	protein-glutamate methylesterase activity
AF_RS07045	COG1657	PFAM Prenyltransferase squalene oxidase
AF_RS07060	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AF_RS07065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AF_RS07100	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AF_RS07150	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AF_RS07165	COG0330	HflC and HflK could
AF_RS07170	COG1615	UPF0182 protein
AF_RS07175	COG1794	racemase activity, acting on amino acids and derivatives
AF_RS07180	COG1078	dGTPase activity
AF_RS07185	COG0072	phenylalanine-tRNA ligase activity
AF_RS07190	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
AF_RS07195	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AF_RS07230	COG1628	Protein of unknown function DUF99
AF_RS07240	COG0430	RNA-3'-phosphate cyclase activity
AF_RS07265	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AF_RS07275	COG1980	fructose-bisphosphate aldolase activity
AF_RS07280	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AF_RS07305	COG1522	sequence-specific DNA binding
AF_RS07310	COG1882	Formate acetyltransferase
AF_RS07315	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AF_RS07320	COG0459	protein refolding
AF_RS07330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AF_RS07330	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AF_RS07385	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AF_RS07415	COG1136	(ABC) transporter
AF_RS07420	COG1136	(ABC) transporter
AF_RS07420	COG0577	efflux transmembrane transporter activity
AF_RS07435	COG0784	Response regulator, receiver
AF_RS07445	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AF_RS07450	COG0346	lactoylglutathione lyase activity
AF_RS07480	COG0343	queuine tRNA-ribosyltransferase activity
AF_RS07485	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
AF_RS07500	COG1056	cytidyltransferase-related domain
AF_RS07500	COG1051	belongs to the nudix hydrolase family
AF_RS07510	COG0081	regulation of translation
AF_RS07515	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AF_RS07545	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AF_RS07610	COG0318	PFAM AMP-dependent synthetase and ligase
AF_RS07620	COG0805	protein transport
AF_RS07645	COG1489	DNA binding
AF_RS07665	COG0426	domain, Protein
AF_RS07680	COG1444	tRNA N-acetyltransferase activity
AF_RS07755	COG2267	carboxylic ester hydrolase activity
AF_RS07760	COG2031	fatty acid transporter
AF_RS07765	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AF_RS07780	COG1695	Transcriptional regulator
AF_RS07800	COG0668	transmembrane transport
AF_RS07820	COG0142	geranyltranstransferase activity
AF_RS07830	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AF_RS07840	COG0482	sulfurtransferase activity
AF_RS07850	COG1196	nuclear chromosome segregation
AF_RS07955	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AF_RS07995	COG1850	ribulose-bisphosphate carboxylase activity
AF_RS08030	COG0037	tRNA processing
AF_RS08050	COG0133	tryptophan synthase activity
AF_RS08055	COG0135	phosphoribosylanthranilate isomerase activity
AF_RS08060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AF_RS08060	COG0512	Glutamine amidotransferase of anthranilate synthase
AF_RS08065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AF_RS08070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AF_RS08085	COG1177	transmembrane transport
AF_RS08090	COG1176	ABC-type spermidine putrescine transport system, permease component I
AF_RS08095	COG3842	ATPase activity
AF_RS08100	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AF_RS08105	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AF_RS08115	COG1113	amino acid transport
AF_RS08130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AF_RS08160	COG1522	sequence-specific DNA binding
AF_RS08165	COG0436	Aminotransferase
AF_RS08170	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AF_RS08200	COG1945	arginine decarboxylase activity
AF_RS08240	COG1850	ribulose-bisphosphate carboxylase activity
AF_RS08245	COG5002	protein histidine kinase activity
AF_RS08250	COG1592	Rubrerythrin
AF_RS08255	COG1024	Enoyl-CoA hydratase
AF_RS08260	COG0124	histidyl-tRNA synthetase
AF_RS08265	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AF_RS08275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AF_RS08310	COG1404	Belongs to the peptidase S8 family
AF_RS08315	COG1404	Belongs to the peptidase S8 family
AF_RS08405	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AF_RS08420	COG0371	Dehydrogenase
AF_RS08430	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AF_RS08435	COG0585	pseudouridine synthase activity
AF_RS08510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AF_RS08515	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AF_RS08525	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AF_RS08540	COG1881	PFAM PEBP family protein
AF_RS08555	COG0674	pyruvate-flavodoxin oxidoreductase activity
AF_RS08560	COG1013	pyruvate-flavodoxin oxidoreductase activity
AF_RS08570	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AF_RS08580	COG2267	carboxylic ester hydrolase activity
AF_RS08590	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AF_RS08635	COG0657	acetylesterase activity
AF_RS08640	COG2427	Protein of unknown function (DUF1641)
AF_RS08650	COG0440	acetolactate synthase activity
AF_RS08655	COG0028	Belongs to the TPP enzyme family
AF_RS08685	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AF_RS08690	COG0281	malic enzyme
AF_RS08695	COG0297	glycogen (starch) synthase activity
AF_RS08705	COG0101	tRNA pseudouridine synthase activity
AF_RS08740	COG1331	Highly conserved protein containing a thioredoxin domain
AF_RS08760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AF_RS08775	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AF_RS08785	COG0004	ammonium transporteR
AF_RS08790	COG0347	Belongs to the P(II) protein family
AF_RS08795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AF_RS08800	COG0004	ammonium transporteR
AF_RS08810	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
AF_RS08815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AF_RS08830	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AF_RS08860	COG0066	3-isopropylmalate dehydratase activity
AF_RS08870	COG2131	deaminase
AF_RS08875	COG0084	hydrolase, TatD family'
AF_RS08885	COG0747	negative chemotaxis
AF_RS08890	COG0601	transmembrane transport
AF_RS08895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AF_RS08900	COG0444	Belongs to the ABC transporter superfamily
AF_RS08905	COG4608	Belongs to the ABC transporter superfamily
AF_RS08910	COG0318	PFAM AMP-dependent synthetase and ligase
AF_RS08915	COG0247	lactate metabolic process
AF_RS08915	COG2181	nitrate reductase activity
AF_RS08920	COG0531	amino acid
AF_RS08935	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AF_RS08940	COG2088	sporulation resulting in formation of a cellular spore
AF_RS08945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AF_RS08950	COG0028	Belongs to the TPP enzyme family
AF_RS08965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AF_RS08985	COG1426	Protein conserved in bacteria
AF_RS08990	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AF_RS09025	COG1363	Peptidase, m42
AF_RS09040	COG0306	phosphate transporter
AF_RS09055	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AF_RS09125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AF_RS09145	COG1309	transcriptional regulator
AF_RS09155	COG1136	(ABC) transporter
AF_RS09185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AF_RS09190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AF_RS09195	COG1007	ATP synthesis coupled electron transport
AF_RS09205	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AF_RS09255	COG0157	Belongs to the NadC ModD family
AF_RS09260	COG0024	Methionine aminopeptidase
AF_RS09265	COG1122	ATPase activity
AF_RS09275	COG0310	cobalt ion transport
AF_RS09300	COG1151	hydroxylamine reductase activity
AF_RS09325	COG0427	acetyl-CoA hydrolase
AF_RS09330	COG0318	PFAM AMP-dependent synthetase and ligase
AF_RS09345	COG0446	pyridine nucleotide-disulphide oxidoreductase
AF_RS09430	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AF_RS09460	COG1131	(ABC) transporter
AF_RS09475	COG0085	RNA polymerase activity
AF_RS09490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AF_RS09500	COG0195	Participates in both transcription termination and antitermination
AF_RS09515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AF_RS09525	COG0655	NAD(P)H dehydrogenase (quinone) activity
AF_RS09535	COG2201	protein-glutamate methylesterase activity
AF_RS09540	COG0358	DNA primase activity
AF_RS09560	COG0200	Binds to the 23S rRNA
AF_RS09570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AF_RS09575	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AF_RS09590	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AF_RS09595	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AF_RS09605	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AF_RS09615	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AF_RS09620	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AF_RS09625	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AF_RS09635	COG0255	Belongs to the universal ribosomal protein uL29 family
AF_RS09640	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AF_RS09645	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AF_RS09650	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AF_RS09655	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AF_RS09660	COG0089	rRNA binding
AF_RS09670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AF_RS09695	COG1229	Formylmethanofuran dehydrogenase subunit A
AF_RS09705	COG0318	PFAM AMP-dependent synthetase and ligase
AF_RS09720	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
AF_RS09725	COG1458	PINc domain ribonuclease
AF_RS09740	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AF_RS09745	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AF_RS09790	COG0140	phosphoribosyl-ATP diphosphatase activity
AF_RS09790	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AF_RS09795	COG4956	integral membrane protein (PIN domain superfamily)
AF_RS09810	COG0154	amidase activity
AF_RS09835	COG1924	4 iron, 4 sulfur cluster binding
AF_RS09840	COG0194	GDP metabolic process
AF_RS09860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AF_RS09885	COG1940	carbohydrate kinase activity
AF_RS09890	COG2078	PFAM AMMECR1 domain protein
AF_RS09900	COG0071	Belongs to the small heat shock protein (HSP20) family
AF_RS09910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AF_RS09915	COG0113	porphobilinogen synthase activity
AF_RS09920	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AF_RS09925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AF_RS09945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AF_RS09950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AF_RS09955	COG1121	(ABC) transporter
AF_RS09960	COG0803	Belongs to the bacterial solute-binding protein 9 family
AF_RS09970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AF_RS10005	COG1047	Peptidyl-prolyl cis-trans
AF_RS10035	COG0733	neurotransmitter:sodium symporter activity
AF_RS10050	COG2181	nitrate reductase activity
AF_RS10050	COG0247	lactate metabolic process
AF_RS10060	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AF_RS10070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AF_RS10080	COG0746	molybdenum cofactor guanylyltransferase activity
AF_RS10085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AF_RS10090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AF_RS10090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AF_RS10100	COG0535	radical SAM domain protein
AF_RS10125	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AF_RS10135	COG0028	Belongs to the TPP enzyme family
AF_RS10140	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AF_RS10145	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_RS10145	COG1024	Enoyl-CoA hydratase
AF_RS10155	COG1454	alcohol dehydrogenase
AF_RS10180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AF_RS10220	COG5002	protein histidine kinase activity
AF_RS10225	COG0318	PFAM AMP-dependent synthetase and ligase
AF_RS10230	COG0006	proline dipeptidase activity
AF_RS10235	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AF_RS10240	COG0109	protoheme IX farnesyltransferase activity
AF_RS10245	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AF_RS10275	COG0528	UMP kinase activity
AF_RS10285	COG1183	phosphatidylcholine synthase activity
AF_RS10290	COG0688	phosphatidylethanolamine metabolic process
AF_RS10315	COG0432	Pfam Uncharacterised protein family UPF0047
AF_RS10320	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AF_RS10325	COG1013	pyruvate-flavodoxin oxidoreductase activity
AF_RS10330	COG0674	pyruvate-flavodoxin oxidoreductase activity
AF_RS10335	COG1144	Oxidoreductase
AF_RS10345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AF_RS10350	COG1960	acyl-CoA dehydrogenase activity
AF_RS10365	COG2255	four-way junction helicase activity
AF_RS10375	COG0552	protein localization to endoplasmic reticulum
AF_RS10420	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AF_RS10430	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
AF_RS10435	COG0352	thiamine-phosphate diphosphorylase activity
AF_RS10440	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AF_RS10480	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AF_RS10485	COG5016	pyruvate
AF_RS10485	COG0511	ligase activity, forming carbon-carbon bonds
AF_RS10505	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AF_RS10555	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AF_RS10560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AF_RS10570	COG0028	Belongs to the TPP enzyme family
AF_RS10615	COG3290	protein histidine kinase activity
AF_RS10625	COG2095	MarC family integral membrane protein
AF_RS10650	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AF_RS10710	COG0583	DNA-binding transcription factor activity
AF_RS10715	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AF_RS10720	COG0436	Aminotransferase
AF_RS10755	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AF_RS10795	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AF_RS10805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AF_RS10815	COG0315	cyclic pyranopterin monophosphate synthase activity
AF_RS10820	COG1335	isochorismatase
AF_RS10840	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AF_RS10850	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AF_RS10950	COG0116	Belongs to the methyltransferase superfamily
AF_RS10950	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AF_RS10955	COG0314	molybdopterin synthase activity
AF_RS10980	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AF_RS10985	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AF_RS10990	COG0045	succinate-CoA ligase (ADP-forming) activity
AF_RS11040	COG2264	protein methyltransferase activity
AF_RS11045	COG1899	peptidyl-lysine modification to peptidyl-hypusine
AF_RS11050	COG1891	lyase activity
AF_RS11065	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AF_RS11070	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AF_RS11105	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
AF_RS11110	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AF_RS11110	COG0352	thiamine-phosphate diphosphorylase activity
AF_RS11110	COG0351	phosphomethylpyrimidine kinase
AF_RS11150	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AF_RS11150	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AF_RS11155	COG5016	pyruvate
AF_RS11155	COG0511	ligase activity, forming carbon-carbon bonds
AF_RS11165	COG0346	lactoylglutathione lyase activity
AF_RS11170	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AF_RS11170	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AF_RS11195	COG0525	valine-tRNA ligase activity
AF_RS11205	COG0301	tRNA thio-modification
AF_RS11205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AF_RS11225	COG1797	cobyrinic acid a,c-diamide synthase activity
AF_RS11240	COG0735	belongs to the Fur family
AF_RS11245	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AF_RS11265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AF_RS11270	COG0459	protein refolding
AF_RS11290	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AF_RS11295	COG0183	Belongs to the thiolase family
AF_RS11300	COG1960	acyl-CoA dehydrogenase activity
AF_RS11330	COG2201	protein-glutamate methylesterase activity
AF_RS11340	COG1546	Belongs to the CinA family
AF_RS11340	COG1058	Belongs to the CinA family
AF_RS11345	COG0137	argininosuccinate synthase activity
AF_RS11350	COG1763	Mo-molybdopterin cofactor biosynthetic process
AF_RS11355	COG0513	Belongs to the DEAD box helicase family
AF_RS11360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AF_RS11365	COG0778	Nitroreductase
AF_RS11365	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AF_RS11370	COG1181	Belongs to the D-alanine--D-alanine ligase family
AF_RS11380	COG2814	Major facilitator Superfamily
AF_RS11415	COG2050	protein possibly involved in aromatic compounds catabolism
AF_RS11420	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AF_RS11425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AF_RS11430	COG0778	Nitroreductase
AF_RS11440	COG0489	protein tyrosine kinase activity
AF_RS11460	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF_RS11475	COG1573	uracil-dna glycosylase
AF_RS11495	COG2414	aldehyde ferredoxin oxidoreductase
AF_RS11505	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AF_RS11510	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AF_RS11515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AF_RS11520	COG0142	geranyltranstransferase activity
AF_RS11525	COG1304	FMN binding
AF_RS11530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AF_RS11535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AF_RS11540	COG0123	including yeast histone deacetylase and acetoin utilization protein
AF_RS11585	COG1213	nucleotidyl transferase
AF_RS11585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AF_RS11595	COG1945	arginine decarboxylase activity
AF_RS11605	COG0189	ligase activity
AF_RS11640	COG1355	regulation of microtubule-based process
AF_RS11655	COG1012	belongs to the aldehyde dehydrogenase family
AF_RS11655	COG2030	dehydratase
AF_RS11660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AF_RS11665	COG1051	belongs to the nudix hydrolase family
AF_RS11665	COG1056	cytidyltransferase-related domain
AF_RS11670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AF_RS11700	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AF_RS11725	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AF_RS11730	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AF_RS11735	COG0154	amidase activity
AF_RS11760	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AF_RS11840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AF_RS11910	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AF_RS11920	COG0719	Fe-S assembly protein
AF_RS11925	COG0436	Aminotransferase
AF_RS11930	COG0456	acetyltransferase
AF_RS11935	COG0318	PFAM AMP-dependent synthetase and ligase
AF_RS11960	COG0483	inositol monophosphate 1-phosphatase activity
AF_RS11965	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AF_RS12000	COG0489	protein tyrosine kinase activity
AF_RS12010	COG0489	protein tyrosine kinase activity
AF_RS12040	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AF_RS12055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AF_RS12100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AF_RS12135	COG1111	helicase
AF_RS12135	COG1205	dead DEAH box helicase
AF_RS12140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AF_RS12150	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AF_RS12165	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AF_RS12170	COG0535	radical SAM domain protein
AF_RS12200	COG0784	Response regulator, receiver
AF_RS12210	COG0495	leucyl-tRNA aminoacylation
AF_RS12230	COG0714	Associated with various cellular activities
AF_RS12250	COG1024	Enoyl-CoA hydratase
AF_RS12260	COG1945	arginine decarboxylase activity
AF_RS12275	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AF_RS12280	COG1518	maintenance of DNA repeat elements
AF_RS12320	COG0642	Histidine kinase
AF_RS12325	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AF_RS12340	COG0438	transferase activity, transferring glycosyl groups
AF_RS12340	COG1216	Glycosyl transferase, family 2
AF_RS12365	COG0318	PFAM AMP-dependent synthetase and ligase
AF_RS12380	COG5002	protein histidine kinase activity
AF_RS12395	COG1378	Sugar-specific transcriptional regulator TrmB
AF_RS12465	COG0640	Transcriptional regulator
AF_RS12470	COG1138	Cytochrome C-type biogenesis protein
AF_RS12495	COG5002	protein histidine kinase activity
AF_RS12585	COG1720	tRNA m6t6A37 methyltransferase activity
AF_RS12600	COG2226	methyltransferase
AF_RS12710	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AF_RS12790	COG3335	DDE superfamily endonuclease