locus-tag	class	description
AFULGI_RS00010	COG4604	ABC transporter, ATP-binding protein
AFULGI_RS00020	COG5012	cobalamin binding
AFULGI_RS00035	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
AFULGI_RS00045	COG5012	cobalamin binding
AFULGI_RS00080	COG0183	Belongs to the thiolase family
AFULGI_RS00095	COG3290	protein histidine kinase activity
AFULGI_RS00105	COG2414	aldehyde ferredoxin oxidoreductase
AFULGI_RS00125	COG4274	PFAM GYD family protein
AFULGI_RS00150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFULGI_RS00155	COG0183	Belongs to the thiolase family
AFULGI_RS00210	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
AFULGI_RS00215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFULGI_RS00260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AFULGI_RS00265	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AFULGI_RS00330	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AFULGI_RS00330	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AFULGI_RS00340	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AFULGI_RS00360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AFULGI_RS00395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFULGI_RS00405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFULGI_RS00405	COG1116	anion transmembrane transporter activity
AFULGI_RS00410	COG0318	PFAM AMP-dependent synthetase and ligase
AFULGI_RS00425	COG3842	ATPase activity
AFULGI_RS00430	COG4149	molybdate abc transporter
AFULGI_RS00435	COG0725	ABC transporter, periplasmic molybdate-binding protein
AFULGI_RS00490	COG0540	Belongs to the ATCase OTCase family
AFULGI_RS00495	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AFULGI_RS00500	COG1830	Aldolase
AFULGI_RS00510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AFULGI_RS00520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AFULGI_RS00535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFULGI_RS00655	COG2226	methyltransferase
AFULGI_RS00715	COG0672	)-iron permease
AFULGI_RS00730	COG0437	4 iron, 4 sulfur cluster binding
AFULGI_RS00765	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFULGI_RS00775	COG1141	Ferredoxin
AFULGI_RS00790	COG0822	iron-sulfur transferase activity
AFULGI_RS00795	COG1104	cysteine desulfurase activity
AFULGI_RS00805	COG0425	Belongs to the sulfur carrier protein TusA family
AFULGI_RS00840	COG0318	PFAM AMP-dependent synthetase and ligase
AFULGI_RS00845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFULGI_RS00850	COG1012	belongs to the aldehyde dehydrogenase family
AFULGI_RS00850	COG2030	dehydratase
AFULGI_RS00860	COG1022	Amp-dependent synthetase and ligase
AFULGI_RS00885	COG2264	protein methyltransferase activity
AFULGI_RS00905	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AFULGI_RS00915	COG2239	Acts as a magnesium transporter
AFULGI_RS00920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AFULGI_RS00940	COG2264	protein methyltransferase activity
AFULGI_RS00945	COG0569	domain protein
AFULGI_RS00945	COG0475	glutathione-regulated potassium exporter activity
AFULGI_RS00955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFULGI_RS00960	COG0439	Biotin carboxylase
AFULGI_RS00995	COG1605	Chorismate mutase
AFULGI_RS00995	COG0077	Prephenate dehydratase
AFULGI_RS01005	COG1465	3-dehydroquinate synthase
AFULGI_RS01010	COG1830	Aldolase
AFULGI_RS01015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFULGI_RS01020	COG0765	amino acid transport
AFULGI_RS01030	COG0501	Belongs to the peptidase M48B family
AFULGI_RS01040	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AFULGI_RS01045	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AFULGI_RS01060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AFULGI_RS01080	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AFULGI_RS01080	COG1918	ferrous iron import across plasma membrane
AFULGI_RS01110	COG2835	tetraacyldisaccharide 4'-kinase activity
AFULGI_RS01115	COG0504	CTP synthase activity
AFULGI_RS01120	COG0519	Catalyzes the synthesis of GMP from XMP
AFULGI_RS01120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AFULGI_RS01125	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFULGI_RS01165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFULGI_RS01175	COG0318	PFAM AMP-dependent synthetase and ligase
AFULGI_RS01185	COG1213	nucleotidyl transferase
AFULGI_RS01185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AFULGI_RS01215	COG0450	alkyl hydroperoxide reductase
AFULGI_RS01245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFULGI_RS01255	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AFULGI_RS01265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AFULGI_RS01280	COG0183	Belongs to the thiolase family
AFULGI_RS01290	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFULGI_RS01300	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AFULGI_RS01305	COG0529	Catalyzes the synthesis of activated sulfate
AFULGI_RS01485	COG1216	Glycosyl transferase, family 2
AFULGI_RS01485	COG1442	glycosyl transferase family 8
AFULGI_RS01495	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AFULGI_RS01500	COG1091	dTDP-4-dehydrorhamnose reductase activity
AFULGI_RS01505	COG1088	dTDP-glucose 4,6-dehydratase activity
AFULGI_RS01525	COG1216	Glycosyl transferase, family 2
AFULGI_RS01580	COG1454	alcohol dehydrogenase
AFULGI_RS01600	COG0655	NAD(P)H dehydrogenase (quinone) activity
AFULGI_RS01605	COG2033	superoxide reductase activity
AFULGI_RS01615	COG2217	Heavy metal translocating P-type atpase
AFULGI_RS01665	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AFULGI_RS01670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFULGI_RS01680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AFULGI_RS01710	COG0470	DNA polymerase III
AFULGI_RS01710	COG1067	ATP-dependent peptidase activity
AFULGI_RS01720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFULGI_RS01725	COG2223	nitrite transmembrane transporter activity
AFULGI_RS01735	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AFULGI_RS01740	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
AFULGI_RS01745	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AFULGI_RS01755	COG0647	UMP catabolic process
AFULGI_RS01810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AFULGI_RS01820	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AFULGI_RS01830	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AFULGI_RS01845	COG1131	(ABC) transporter
AFULGI_RS01855	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFULGI_RS01885	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFULGI_RS01895	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AFULGI_RS01930	COG0436	Aminotransferase
AFULGI_RS01935	COG4191	Histidine kinase
AFULGI_RS01940	COG0215	cysteine-tRNA ligase activity
AFULGI_RS01975	COG0434	BtpA family
AFULGI_RS01990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AFULGI_RS01990	COG1648	precorrin-2 dehydrogenase activity
AFULGI_RS01995	COG2221	Nitrite and sulphite reductase 4Fe-4S
AFULGI_RS02000	COG2221	Nitrite and sulphite reductase 4Fe-4S
AFULGI_RS02015	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AFULGI_RS02030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFULGI_RS02045	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFULGI_RS02050	COG1024	Enoyl-CoA hydratase
AFULGI_RS02055	COG1960	acyl-CoA dehydrogenase activity
AFULGI_RS02065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFULGI_RS02075	COG0720	synthase
AFULGI_RS02080	COG0602	queuosine metabolic process
AFULGI_RS02085	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AFULGI_RS02115	COG5002	protein histidine kinase activity
AFULGI_RS02120	COG2201	protein-glutamate methylesterase activity
AFULGI_RS02125	COG3290	protein histidine kinase activity
AFULGI_RS02150	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFULGI_RS02150	COG1902	pentaerythritol trinitrate reductase activity
AFULGI_RS02165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFULGI_RS02170	COG2409	Drug exporters of the RND superfamily
AFULGI_RS02210	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AFULGI_RS02225	COG2358	TRAP transporter, solute receptor (TAXI family
AFULGI_RS02230	COG1013	pyruvate-flavodoxin oxidoreductase activity
AFULGI_RS02235	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AFULGI_RS02235	COG0674	pyruvate-flavodoxin oxidoreductase activity
AFULGI_RS02255	COG2217	Heavy metal translocating P-type atpase
AFULGI_RS02260	COG1522	sequence-specific DNA binding
AFULGI_RS02265	COG0798	PFAM Bile acid sodium symporter
AFULGI_RS02275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFULGI_RS02280	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AFULGI_RS02295	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AFULGI_RS02300	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AFULGI_RS02310	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFULGI_RS02310	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFULGI_RS02350	COG1185	polyribonucleotide nucleotidyltransferase activity
AFULGI_RS02355	COG1185	polyribonucleotide nucleotidyltransferase activity
AFULGI_RS02360	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AFULGI_RS02375	COG0417	DNA replication proofreading
AFULGI_RS02420	COG0247	lactate metabolic process
AFULGI_RS02420	COG2181	nitrate reductase activity
AFULGI_RS02430	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AFULGI_RS02435	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AFULGI_RS02450	COG2226	methyltransferase
AFULGI_RS02495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFULGI_RS02520	COG1185	polyribonucleotide nucleotidyltransferase activity
AFULGI_RS02525	COG0543	2 iron, 2 sulfur cluster binding
AFULGI_RS02535	COG0187	DNA topoisomerase II activity
AFULGI_RS02540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AFULGI_RS02560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AFULGI_RS02575	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AFULGI_RS02605	COG0247	lactate metabolic process
AFULGI_RS02620	COG0247	lactate metabolic process
AFULGI_RS02625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AFULGI_RS02635	COG0402	S-adenosylhomocysteine deaminase activity
AFULGI_RS02640	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AFULGI_RS02645	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AFULGI_RS02650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AFULGI_RS02665	COG0425	Belongs to the sulfur carrier protein TusA family
AFULGI_RS02670	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFULGI_RS02680	COG0482	sulfurtransferase activity
AFULGI_RS02710	COG1104	cysteine desulfurase activity
AFULGI_RS02715	COG0822	iron-sulfur transferase activity
AFULGI_RS02745	COG1846	Transcriptional regulator
AFULGI_RS02810	COG0175	sulfate reduction
AFULGI_RS02840	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AFULGI_RS02845	COG0758	DNA mediated transformation
AFULGI_RS02860	COG0546	phosphoglycolate phosphatase activity
AFULGI_RS02910	COG0420	3'-5' exonuclease activity
AFULGI_RS02935	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AFULGI_RS02955	COG1353	crispr-associated protein
AFULGI_RS02965	COG1337	RAMP superfamily
AFULGI_RS03015	COG2002	toxin-antitoxin pair type II binding
AFULGI_RS03045	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AFULGI_RS03070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFULGI_RS03100	COG0463	Glycosyl transferase, family 2
AFULGI_RS03130	COG0343	queuine tRNA-ribosyltransferase activity
AFULGI_RS03135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AFULGI_RS03150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFULGI_RS03170	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFULGI_RS03215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AFULGI_RS03285	COG0297	glycogen (starch) synthase activity
AFULGI_RS03310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AFULGI_RS03320	COG1793	dna ligase
AFULGI_RS03345	COG0473	3-isopropylmalate dehydrogenase activity
AFULGI_RS03350	COG0066	3-isopropylmalate dehydratase activity
AFULGI_RS03365	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AFULGI_RS03370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AFULGI_RS03380	COG2358	TRAP transporter, solute receptor (TAXI family
AFULGI_RS03400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFULGI_RS03405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFULGI_RS03405	COG1116	anion transmembrane transporter activity
AFULGI_RS03420	COG0010	Belongs to the arginase family
AFULGI_RS03425	COG0538	isocitrate dehydrogenase activity
AFULGI_RS03460	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFULGI_RS03465	COG0312	modulator of DNA gyrase
AFULGI_RS03490	COG1694	Mazg nucleotide pyrophosphohydrolase
AFULGI_RS03500	COG1053	succinate dehydrogenase
AFULGI_RS03500	COG0431	NADPH-dependent FMN reductase
AFULGI_RS03500	COG3976	FMN-binding domain protein
AFULGI_RS03505	COG1233	COG1233 Phytoene dehydrogenase and related
AFULGI_RS03515	COG0515	serine threonine protein kinase
AFULGI_RS03515	COG2815	serine threonine protein kinase
AFULGI_RS03535	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AFULGI_RS03540	COG1960	acyl-CoA dehydrogenase activity
AFULGI_RS03545	COG0318	PFAM AMP-dependent synthetase and ligase
AFULGI_RS03565	COG0563	adenylate kinase activity
AFULGI_RS03570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFULGI_RS03590	COG1053	succinate dehydrogenase
AFULGI_RS03615	COG1024	Enoyl-CoA hydratase
AFULGI_RS03625	COG0318	PFAM AMP-dependent synthetase and ligase
AFULGI_RS03645	COG2871	sodium ion transport
AFULGI_RS03675	COG2894	cell division
AFULGI_RS03700	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
AFULGI_RS03725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AFULGI_RS03740	COG0574	Belongs to the PEP-utilizing enzyme family
AFULGI_RS03740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFULGI_RS03755	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AFULGI_RS03775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFULGI_RS03795	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AFULGI_RS03820	COG0310	cobalt ion transport
AFULGI_RS03835	COG1122	ATPase activity
AFULGI_RS03845	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AFULGI_RS03865	COG2104	thiamine diphosphate biosynthetic process
AFULGI_RS03885	COG0432	Pfam Uncharacterised protein family UPF0047
AFULGI_RS03895	COG0864	Transcriptional regulator
AFULGI_RS03905	COG0167	dihydroorotate dehydrogenase activity
AFULGI_RS03915	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AFULGI_RS03930	COG1013	pyruvate-flavodoxin oxidoreductase activity
AFULGI_RS03955	COG0247	lactate metabolic process
AFULGI_RS03955	COG2181	nitrate reductase activity
AFULGI_RS03960	COG1227	inorganic diphosphatase activity
AFULGI_RS04015	COG0105	UTP biosynthetic process
AFULGI_RS04020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AFULGI_RS04055	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AFULGI_RS04080	COG0009	L-threonylcarbamoyladenylate synthase
AFULGI_RS04095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFULGI_RS04105	COG0598	Magnesium transport protein CorA
AFULGI_RS04120	COG0697	spore germination
AFULGI_RS04165	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AFULGI_RS04170	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AFULGI_RS04180	COG0019	diaminopimelate decarboxylase activity
AFULGI_RS04215	COG1620	l-lactate permease
AFULGI_RS04225	COG0277	FAD linked oxidase domain protein
AFULGI_RS04245	COG1139	Iron-sulfur cluster binding protein
AFULGI_RS04260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFULGI_RS04270	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
AFULGI_RS04285	COG1254	Belongs to the acylphosphatase family
AFULGI_RS04290	COG0107	imidazoleglycerol-phosphate synthase activity
AFULGI_RS04340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AFULGI_RS04340	COG1773	rubredoxin
AFULGI_RS04345	COG1592	Rubrerythrin
AFULGI_RS04355	COG2033	superoxide reductase activity
AFULGI_RS04370	COG0569	domain protein
AFULGI_RS04380	COG0318	PFAM AMP-dependent synthetase and ligase
AFULGI_RS04385	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AFULGI_RS04405	COG1960	acyl-CoA dehydrogenase activity
AFULGI_RS04415	COG0517	IMP dehydrogenase activity
AFULGI_RS04415	COG1125	glycine betaine transport
AFULGI_RS04420	COG0517	IMP dehydrogenase activity
AFULGI_RS04440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AFULGI_RS04445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AFULGI_RS04445	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AFULGI_RS04455	COG0039	L-malate dehydrogenase activity
AFULGI_RS04505	COG0596	Alpha beta hydrolase
AFULGI_RS04515	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AFULGI_RS04525	COG0277	FAD linked oxidase domain protein
AFULGI_RS04530	COG0393	Putative heavy-metal-binding
AFULGI_RS04535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AFULGI_RS04545	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AFULGI_RS04565	COG1525	nuclease
AFULGI_RS04565	COG4085	toxin activity
AFULGI_RS04565	COG0737	Belongs to the 5'-nucleotidase family
AFULGI_RS04590	COG1773	rubredoxin
AFULGI_RS04600	COG2205	protein histidine kinase activity
AFULGI_RS04605	COG0252	asparaginase activity
AFULGI_RS04610	COG0165	Argininosuccinate lyase
AFULGI_RS04630	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AFULGI_RS04635	COG3845	ABC transporter
AFULGI_RS04640	COG4603	Belongs to the binding-protein-dependent transport system permease family
AFULGI_RS04645	COG1079	Belongs to the binding-protein-dependent transport system permease family
AFULGI_RS04665	COG3290	protein histidine kinase activity
AFULGI_RS04700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFULGI_RS04715	COG2271	Major facilitator Superfamily
AFULGI_RS04725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AFULGI_RS04730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AFULGI_RS04750	COG0023	Translation Initiation Factor
AFULGI_RS04760	COG0423	glycine-tRNA ligase activity
AFULGI_RS04765	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AFULGI_RS04780	COG0017	Asparaginyl-tRNA synthetase
AFULGI_RS04835	COG0546	phosphoglycolate phosphatase activity
AFULGI_RS04840	COG0284	orotidine-5'-phosphate decarboxylase activity
AFULGI_RS04845	COG0303	'Molybdopterin
AFULGI_RS04850	COG0303	'Molybdopterin
AFULGI_RS04860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AFULGI_RS04870	COG0460	homoserine dehydrogenase
AFULGI_RS04880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFULGI_RS04885	COG0051	transcription antitermination factor activity, RNA binding
AFULGI_RS04890	COG1234	tRNA 3'-trailer cleavage
AFULGI_RS04905	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AFULGI_RS04910	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AFULGI_RS04940	COG0174	glutamine synthetase
AFULGI_RS04950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFULGI_RS04955	COG0067	glutamate synthase
AFULGI_RS04980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFULGI_RS04990	COG1137	ATPase activity
AFULGI_RS05010	COG1024	Enoyl-CoA hydratase
AFULGI_RS05040	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFULGI_RS05055	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AFULGI_RS05060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AFULGI_RS05065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AFULGI_RS05070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFULGI_RS05075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFULGI_RS05080	COG0004	ammonium transporteR
AFULGI_RS05095	COG1174	glycine betaine transport
AFULGI_RS05100	COG0517	IMP dehydrogenase activity
AFULGI_RS05100	COG1125	glycine betaine transport
AFULGI_RS05120	COG4555	ABC transporter
AFULGI_RS05125	COG0131	Imidazoleglycerol-phosphate dehydratase
AFULGI_RS05125	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AFULGI_RS05130	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AFULGI_RS05155	COG0559	Belongs to the binding-protein-dependent transport system permease family
AFULGI_RS05185	COG1418	mRNA catabolic process
AFULGI_RS05200	COG0402	S-adenosylhomocysteine deaminase activity
AFULGI_RS05215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AFULGI_RS05240	COG0842	Transport permease protein
AFULGI_RS05245	COG1131	(ABC) transporter
AFULGI_RS05300	COG0129	dihydroxy-acid dehydratase activity
AFULGI_RS05315	COG0577	efflux transmembrane transporter activity
AFULGI_RS05320	COG1136	(ABC) transporter
AFULGI_RS05335	COG1131	(ABC) transporter
AFULGI_RS05345	COG0644	oxidoreductase
AFULGI_RS05350	COG1110	DNA topoisomerase II activity
AFULGI_RS05355	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFULGI_RS05360	COG1960	acyl-CoA dehydrogenase activity
AFULGI_RS05370	COG0183	Belongs to the thiolase family
AFULGI_RS05375	COG0318	PFAM AMP-dependent synthetase and ligase
AFULGI_RS05380	COG0433	COG0433 Predicted ATPase
AFULGI_RS05390	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AFULGI_RS05400	COG0840	transmembrane signaling receptor activity
AFULGI_RS05400	COG3290	protein histidine kinase activity
AFULGI_RS05420	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AFULGI_RS05425	COG1776	CheC inhibitor of MCP methylation
AFULGI_RS05430	COG2198	Histidine kinase
AFULGI_RS05430	COG0643	Histidine kinase
AFULGI_RS05435	COG2201	protein-glutamate methylesterase activity
AFULGI_RS05440	COG2201	protein-glutamate methylesterase activity
AFULGI_RS05450	COG0835	chemotaxis
AFULGI_RS05555	COG2201	protein-glutamate methylesterase activity
AFULGI_RS05560	COG1121	(ABC) transporter
AFULGI_RS05585	COG4145	pantothenate transmembrane transporter activity
AFULGI_RS05595	COG1598	PFAM Uncharacterised protein family UPF0150
AFULGI_RS05775	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AFULGI_RS05800	COG1185	polyribonucleotide nucleotidyltransferase activity
AFULGI_RS05825	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFULGI_RS05845	COG0535	radical SAM domain protein
AFULGI_RS05860	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AFULGI_RS05880	COG0148	phosphopyruvate hydratase activity
AFULGI_RS05885	COG0052	Belongs to the universal ribosomal protein uS2 family
AFULGI_RS05915	COG1131	(ABC) transporter
AFULGI_RS05930	COG1213	nucleotidyl transferase
AFULGI_RS05945	COG0427	acetyl-CoA hydrolase
AFULGI_RS05950	COG0126	phosphoglycerate kinase activity
AFULGI_RS05955	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AFULGI_RS05960	COG1522	sequence-specific DNA binding
AFULGI_RS05965	COG1201	RNA secondary structure unwinding
AFULGI_RS06015	COG0151	Belongs to the GarS family
AFULGI_RS06025	COG1269	ATP hydrolysis coupled proton transport
AFULGI_RS06040	COG1527	subunit (C
AFULGI_RS06050	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AFULGI_RS06055	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
AFULGI_RS06060	COG1394	ATPase activity, coupled to movement of substances
AFULGI_RS06065	COG1268	BioY protein
AFULGI_RS06070	COG1122	ATPase activity
AFULGI_RS06095	COG1960	acyl-CoA dehydrogenase activity
AFULGI_RS06105	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFULGI_RS06130	COG1160	GTP binding
AFULGI_RS06145	COG4191	Histidine kinase
AFULGI_RS06155	COG0516	GMP reductase activity
AFULGI_RS06155	COG0517	IMP dehydrogenase activity
AFULGI_RS06160	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AFULGI_RS06170	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFULGI_RS06175	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AFULGI_RS06195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AFULGI_RS06200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFULGI_RS06205	COG0183	Belongs to the thiolase family
AFULGI_RS06210	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AFULGI_RS06245	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFULGI_RS06250	COG1028	Short-chain dehydrogenase reductase Sdr
AFULGI_RS06265	COG3246	L-lysine catabolic process to acetate
AFULGI_RS06275	COG0857	belongs to the CobB CobQ family
AFULGI_RS06290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AFULGI_RS06295	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AFULGI_RS06310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AFULGI_RS06330	COG1418	mRNA catabolic process
AFULGI_RS06355	COG2409	Drug exporters of the RND superfamily
AFULGI_RS06365	COG1378	Sugar-specific transcriptional regulator TrmB
AFULGI_RS06405	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AFULGI_RS06410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AFULGI_RS06415	COG0181	hydroxymethylbilane synthase activity
AFULGI_RS06420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AFULGI_RS06430	COG0475	glutathione-regulated potassium exporter activity
AFULGI_RS06440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFULGI_RS06445	COG1811	Na channel or pump
AFULGI_RS06480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AFULGI_RS06485	COG2201	protein-glutamate methylesterase activity
AFULGI_RS06490	COG0116	Belongs to the methyltransferase superfamily
AFULGI_RS06500	COG0517	IMP dehydrogenase activity
AFULGI_RS06500	COG1125	glycine betaine transport
AFULGI_RS06505	COG0047	phosphoribosylformylglycinamidine synthase activity
AFULGI_RS06515	COG1902	pentaerythritol trinitrate reductase activity
AFULGI_RS06515	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFULGI_RS06530	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AFULGI_RS06560	COG0525	valine-tRNA ligase activity
AFULGI_RS06580	COG1429	ligase activity, forming nitrogen-metal bonds
AFULGI_RS06590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AFULGI_RS06600	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AFULGI_RS06605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AFULGI_RS06610	COG0505	Belongs to the CarA family
AFULGI_RS06615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AFULGI_RS06620	COG1691	(AIR) carboxylase
AFULGI_RS06630	COG0505	Belongs to the CarA family
AFULGI_RS06645	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AFULGI_RS06655	COG0693	protein deglycase activity
AFULGI_RS06675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFULGI_RS06685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFULGI_RS06690	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFULGI_RS06690	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFULGI_RS06710	COG0183	Belongs to the thiolase family
AFULGI_RS06720	COG1960	acyl-CoA dehydrogenase activity
AFULGI_RS06745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFULGI_RS06760	COG1131	(ABC) transporter
AFULGI_RS06770	COG0149	triose-phosphate isomerase activity
AFULGI_RS06775	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
AFULGI_RS06790	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AFULGI_RS06795	COG0170	dolichyl monophosphate biosynthetic process
AFULGI_RS06800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AFULGI_RS06820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AFULGI_RS06825	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AFULGI_RS06850	COG0519	Catalyzes the synthesis of GMP from XMP
AFULGI_RS06850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AFULGI_RS06855	COG0037	tRNA processing
AFULGI_RS06880	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AFULGI_RS06890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFULGI_RS06930	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AFULGI_RS06940	COG1492	cobalamin metabolic process
AFULGI_RS06945	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AFULGI_RS06950	COG0372	Belongs to the citrate synthase family
AFULGI_RS06965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFULGI_RS06970	COG0805	protein transport
AFULGI_RS06990	COG1773	rubredoxin
AFULGI_RS06995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFULGI_RS07015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AFULGI_RS07015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AFULGI_RS07030	COG0573	inorganic phosphate transmembrane transporter activity
AFULGI_RS07035	COG0581	inorganic phosphate transmembrane transporter activity
AFULGI_RS07040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AFULGI_RS07065	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AFULGI_RS07075	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AFULGI_RS07080	COG0375	protein maturation
AFULGI_RS07095	COG0409	Hydrogenase expression formation protein
AFULGI_RS07105	COG3259	Nickel-dependent hydrogenase
AFULGI_RS07110	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
AFULGI_RS07135	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AFULGI_RS07150	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AFULGI_RS07165	COG2201	protein-glutamate methylesterase activity
AFULGI_RS07175	COG2002	toxin-antitoxin pair type II binding
AFULGI_RS07225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFULGI_RS07230	COG1657	PFAM Prenyltransferase squalene oxidase
AFULGI_RS07285	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AFULGI_RS07335	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AFULGI_RS07350	COG0330	HflC and HflK could
AFULGI_RS07355	COG1615	UPF0182 protein
AFULGI_RS07360	COG1794	racemase activity, acting on amino acids and derivatives
AFULGI_RS07365	COG1078	dGTPase activity
AFULGI_RS07370	COG0072	phenylalanine-tRNA ligase activity
AFULGI_RS07375	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
AFULGI_RS07380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AFULGI_RS07415	COG1628	Protein of unknown function DUF99
AFULGI_RS07425	COG0430	RNA-3'-phosphate cyclase activity
AFULGI_RS07450	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFULGI_RS07460	COG1980	fructose-bisphosphate aldolase activity
AFULGI_RS07465	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AFULGI_RS07490	COG1522	sequence-specific DNA binding
AFULGI_RS07500	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AFULGI_RS07505	COG0459	protein refolding
AFULGI_RS07515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFULGI_RS07515	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFULGI_RS07665	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AFULGI_RS07775	COG1598	PFAM Uncharacterised protein family UPF0150
AFULGI_RS08135	COG1196	nuclear chromosome segregation
AFULGI_RS08140	COG0420	3'-5' exonuclease activity
AFULGI_RS08280	COG1136	(ABC) transporter
AFULGI_RS08285	COG1136	(ABC) transporter
AFULGI_RS08285	COG0577	efflux transmembrane transporter activity
AFULGI_RS08300	COG0784	Response regulator, receiver
AFULGI_RS08310	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AFULGI_RS08315	COG0346	lactoylglutathione lyase activity
AFULGI_RS08345	COG0343	queuine tRNA-ribosyltransferase activity
AFULGI_RS08350	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
AFULGI_RS08365	COG1051	belongs to the nudix hydrolase family
AFULGI_RS08365	COG1056	cytidyltransferase-related domain
AFULGI_RS08375	COG0081	regulation of translation
AFULGI_RS08380	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AFULGI_RS08410	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AFULGI_RS08475	COG0318	PFAM AMP-dependent synthetase and ligase
AFULGI_RS08485	COG0805	protein transport
AFULGI_RS08510	COG1489	DNA binding
AFULGI_RS08530	COG0426	domain, Protein
AFULGI_RS08545	COG1444	tRNA N-acetyltransferase activity
AFULGI_RS08620	COG2267	carboxylic ester hydrolase activity
AFULGI_RS08625	COG2031	fatty acid transporter
AFULGI_RS08630	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AFULGI_RS08645	COG1695	Transcriptional regulator
AFULGI_RS08665	COG0668	transmembrane transport
AFULGI_RS08685	COG0142	geranyltranstransferase activity
AFULGI_RS08695	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AFULGI_RS08710	COG0482	sulfurtransferase activity
AFULGI_RS08720	COG1196	nuclear chromosome segregation
AFULGI_RS08820	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AFULGI_RS08860	COG1850	ribulose-bisphosphate carboxylase activity
AFULGI_RS08895	COG0037	tRNA processing
AFULGI_RS08915	COG0133	tryptophan synthase activity
AFULGI_RS08920	COG0135	phosphoribosylanthranilate isomerase activity
AFULGI_RS08925	COG0512	Glutamine amidotransferase of anthranilate synthase
AFULGI_RS08925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFULGI_RS08930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AFULGI_RS08935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFULGI_RS08940	COG0134	indole-3-glycerol-phosphate synthase activity
AFULGI_RS08950	COG1177	transmembrane transport
AFULGI_RS08955	COG1176	ABC-type spermidine putrescine transport system, permease component I
AFULGI_RS08960	COG3842	ATPase activity
AFULGI_RS08965	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AFULGI_RS08970	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AFULGI_RS08980	COG1113	amino acid transport
AFULGI_RS08995	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AFULGI_RS09010	COG2855	membrane
AFULGI_RS09030	COG0436	Aminotransferase
AFULGI_RS09035	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AFULGI_RS09065	COG1945	arginine decarboxylase activity
AFULGI_RS09085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AFULGI_RS09100	COG1850	ribulose-bisphosphate carboxylase activity
AFULGI_RS09105	COG5002	protein histidine kinase activity
AFULGI_RS09110	COG1592	Rubrerythrin
AFULGI_RS09115	COG1024	Enoyl-CoA hydratase
AFULGI_RS09120	COG0124	histidyl-tRNA synthetase
AFULGI_RS09125	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AFULGI_RS09135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AFULGI_RS09170	COG1404	Belongs to the peptidase S8 family
AFULGI_RS09170	COG1404	Belongs to the peptidase S8 family
AFULGI_RS09260	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AFULGI_RS09275	COG0371	Dehydrogenase
AFULGI_RS09285	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AFULGI_RS09290	COG0585	pseudouridine synthase activity
AFULGI_RS09365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AFULGI_RS09370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AFULGI_RS09380	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AFULGI_RS09395	COG1881	PFAM PEBP family protein
AFULGI_RS09410	COG0674	pyruvate-flavodoxin oxidoreductase activity
AFULGI_RS09415	COG1013	pyruvate-flavodoxin oxidoreductase activity
AFULGI_RS09425	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AFULGI_RS09435	COG2267	carboxylic ester hydrolase activity
AFULGI_RS09445	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AFULGI_RS09480	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AFULGI_RS09490	COG0657	acetylesterase activity
AFULGI_RS09495	COG2427	Protein of unknown function (DUF1641)
AFULGI_RS09505	COG0440	acetolactate synthase activity
AFULGI_RS09510	COG0028	Belongs to the TPP enzyme family
AFULGI_RS09540	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AFULGI_RS09545	COG0281	malic enzyme
AFULGI_RS09550	COG0297	glycogen (starch) synthase activity
AFULGI_RS09560	COG0101	tRNA pseudouridine synthase activity
AFULGI_RS09595	COG1331	Highly conserved protein containing a thioredoxin domain
AFULGI_RS09615	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AFULGI_RS09630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AFULGI_RS09640	COG0004	ammonium transporteR
AFULGI_RS09645	COG0347	Belongs to the P(II) protein family
AFULGI_RS09650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFULGI_RS09655	COG0004	ammonium transporteR
AFULGI_RS09665	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
AFULGI_RS09670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AFULGI_RS09685	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AFULGI_RS09715	COG0066	3-isopropylmalate dehydratase activity
AFULGI_RS09725	COG2131	deaminase
AFULGI_RS09730	COG0084	hydrolase, TatD family'
AFULGI_RS09740	COG0747	negative chemotaxis
AFULGI_RS09745	COG0601	transmembrane transport
AFULGI_RS09750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFULGI_RS09755	COG0444	Belongs to the ABC transporter superfamily
AFULGI_RS09760	COG4608	Belongs to the ABC transporter superfamily
AFULGI_RS09765	COG0318	PFAM AMP-dependent synthetase and ligase
AFULGI_RS09770	COG0247	lactate metabolic process
AFULGI_RS09770	COG2181	nitrate reductase activity
AFULGI_RS09775	COG0531	amino acid
AFULGI_RS09790	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AFULGI_RS09795	COG2088	sporulation resulting in formation of a cellular spore
AFULGI_RS09800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AFULGI_RS09805	COG0028	Belongs to the TPP enzyme family
AFULGI_RS09820	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFULGI_RS09840	COG1426	Protein conserved in bacteria
AFULGI_RS09845	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AFULGI_RS09880	COG1363	Peptidase, m42
AFULGI_RS09910	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AFULGI_RS09950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AFULGI_RS09975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFULGI_RS09995	COG1309	transcriptional regulator
AFULGI_RS10005	COG1136	(ABC) transporter
AFULGI_RS10035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFULGI_RS10040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFULGI_RS10045	COG1007	ATP synthesis coupled electron transport
AFULGI_RS10055	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFULGI_RS10105	COG0157	Belongs to the NadC ModD family
AFULGI_RS10110	COG0024	Methionine aminopeptidase
AFULGI_RS10115	COG1122	ATPase activity
AFULGI_RS10125	COG0310	cobalt ion transport
AFULGI_RS10145	COG1151	hydroxylamine reductase activity
AFULGI_RS10170	COG0427	acetyl-CoA hydrolase
AFULGI_RS10175	COG0318	PFAM AMP-dependent synthetase and ligase
AFULGI_RS10190	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFULGI_RS10295	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AFULGI_RS10325	COG1131	(ABC) transporter
AFULGI_RS10340	COG0085	RNA polymerase activity
AFULGI_RS10355	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AFULGI_RS10365	COG0195	Participates in both transcription termination and antitermination
AFULGI_RS10380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AFULGI_RS10390	COG0655	NAD(P)H dehydrogenase (quinone) activity
AFULGI_RS10400	COG2201	protein-glutamate methylesterase activity
AFULGI_RS10405	COG0358	DNA primase activity
AFULGI_RS10425	COG0200	Binds to the 23S rRNA
AFULGI_RS10435	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AFULGI_RS10440	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AFULGI_RS10455	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AFULGI_RS10460	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AFULGI_RS10470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AFULGI_RS10480	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AFULGI_RS10485	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AFULGI_RS10490	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AFULGI_RS10500	COG0255	Belongs to the universal ribosomal protein uL29 family
AFULGI_RS10505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AFULGI_RS10510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AFULGI_RS10515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AFULGI_RS10520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AFULGI_RS10525	COG0089	rRNA binding
AFULGI_RS10535	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AFULGI_RS10560	COG1229	Formylmethanofuran dehydrogenase subunit A
AFULGI_RS10570	COG0318	PFAM AMP-dependent synthetase and ligase
AFULGI_RS10585	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
AFULGI_RS10590	COG1458	PINc domain ribonuclease
AFULGI_RS10605	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFULGI_RS10610	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFULGI_RS10650	COG0140	phosphoribosyl-ATP diphosphatase activity
AFULGI_RS10650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AFULGI_RS10655	COG4956	integral membrane protein (PIN domain superfamily)
AFULGI_RS10670	COG0154	amidase activity
AFULGI_RS10695	COG1924	4 iron, 4 sulfur cluster binding
AFULGI_RS10700	COG0194	GDP metabolic process
AFULGI_RS10720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AFULGI_RS10745	COG1940	carbohydrate kinase activity
AFULGI_RS10750	COG2078	PFAM AMMECR1 domain protein
AFULGI_RS10760	COG0071	Belongs to the small heat shock protein (HSP20) family
AFULGI_RS10770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AFULGI_RS10775	COG0113	porphobilinogen synthase activity
AFULGI_RS10780	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AFULGI_RS10785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFULGI_RS10805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFULGI_RS10810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFULGI_RS10820	COG0803	Belongs to the bacterial solute-binding protein 9 family
AFULGI_RS10830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AFULGI_RS10865	COG1047	Peptidyl-prolyl cis-trans
AFULGI_RS10895	COG0733	neurotransmitter:sodium symporter activity
AFULGI_RS10910	COG2181	nitrate reductase activity
AFULGI_RS10910	COG0247	lactate metabolic process
AFULGI_RS10920	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AFULGI_RS10930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFULGI_RS10940	COG0746	molybdenum cofactor guanylyltransferase activity
AFULGI_RS10945	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AFULGI_RS10950	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFULGI_RS10950	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFULGI_RS10985	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AFULGI_RS10995	COG0028	Belongs to the TPP enzyme family
AFULGI_RS11000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AFULGI_RS11005	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFULGI_RS11005	COG1024	Enoyl-CoA hydratase
AFULGI_RS11015	COG1454	alcohol dehydrogenase
AFULGI_RS11040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFULGI_RS11080	COG4191	Histidine kinase
AFULGI_RS11085	COG5002	protein histidine kinase activity
AFULGI_RS11090	COG0318	PFAM AMP-dependent synthetase and ligase
AFULGI_RS11095	COG0006	proline dipeptidase activity
AFULGI_RS11100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AFULGI_RS11105	COG0109	protoheme IX farnesyltransferase activity
AFULGI_RS11115	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AFULGI_RS11145	COG0528	UMP kinase activity
AFULGI_RS11155	COG1183	phosphatidylcholine synthase activity
AFULGI_RS11160	COG0688	phosphatidylethanolamine metabolic process
AFULGI_RS11185	COG0432	Pfam Uncharacterised protein family UPF0047
AFULGI_RS11190	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AFULGI_RS11195	COG1013	pyruvate-flavodoxin oxidoreductase activity
AFULGI_RS11200	COG0674	pyruvate-flavodoxin oxidoreductase activity
AFULGI_RS11205	COG1144	Oxidoreductase
AFULGI_RS11215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFULGI_RS11220	COG1960	acyl-CoA dehydrogenase activity
AFULGI_RS11235	COG2255	four-way junction helicase activity
AFULGI_RS11245	COG0552	protein localization to endoplasmic reticulum
AFULGI_RS11300	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
AFULGI_RS11305	COG0352	thiamine-phosphate diphosphorylase activity
AFULGI_RS11310	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AFULGI_RS11350	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AFULGI_RS11355	COG5016	pyruvate
AFULGI_RS11355	COG0511	ligase activity, forming carbon-carbon bonds
AFULGI_RS11375	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AFULGI_RS11410	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AFULGI_RS11415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFULGI_RS11425	COG0028	Belongs to the TPP enzyme family
AFULGI_RS11470	COG3290	protein histidine kinase activity
AFULGI_RS11480	COG2095	MarC family integral membrane protein
AFULGI_RS11505	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFULGI_RS11570	COG0583	DNA-binding transcription factor activity
AFULGI_RS11575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AFULGI_RS11580	COG0436	Aminotransferase
AFULGI_RS11615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AFULGI_RS11655	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AFULGI_RS11665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFULGI_RS11675	COG0315	cyclic pyranopterin monophosphate synthase activity
AFULGI_RS11680	COG1335	isochorismatase
AFULGI_RS11700	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AFULGI_RS11710	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AFULGI_RS11805	COG1201	RNA secondary structure unwinding
AFULGI_RS11810	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AFULGI_RS11810	COG0116	Belongs to the methyltransferase superfamily
AFULGI_RS11815	COG0314	molybdopterin synthase activity
AFULGI_RS11840	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AFULGI_RS11845	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AFULGI_RS11850	COG0045	succinate-CoA ligase (ADP-forming) activity
AFULGI_RS11905	COG2264	protein methyltransferase activity
AFULGI_RS11910	COG1899	peptidyl-lysine modification to peptidyl-hypusine
AFULGI_RS11915	COG1891	lyase activity
AFULGI_RS11930	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AFULGI_RS11935	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AFULGI_RS11970	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
AFULGI_RS11975	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AFULGI_RS11975	COG0352	thiamine-phosphate diphosphorylase activity
AFULGI_RS11975	COG0351	phosphomethylpyrimidine kinase
AFULGI_RS12015	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFULGI_RS12015	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFULGI_RS12020	COG0511	ligase activity, forming carbon-carbon bonds
AFULGI_RS12020	COG5016	pyruvate
AFULGI_RS12030	COG0346	lactoylglutathione lyase activity
AFULGI_RS12035	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFULGI_RS12035	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFULGI_RS12050	COG0525	valine-tRNA ligase activity
AFULGI_RS12060	COG0301	tRNA thio-modification
AFULGI_RS12060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFULGI_RS12145	COG1797	cobyrinic acid a,c-diamide synthase activity
AFULGI_RS12160	COG0735	belongs to the Fur family
AFULGI_RS12165	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AFULGI_RS12185	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AFULGI_RS12190	COG0459	protein refolding
AFULGI_RS12210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AFULGI_RS12215	COG0183	Belongs to the thiolase family
AFULGI_RS12220	COG1960	acyl-CoA dehydrogenase activity
AFULGI_RS12225	COG4581	dead DEAH box helicase
AFULGI_RS12250	COG2201	protein-glutamate methylesterase activity
AFULGI_RS12260	COG1546	Belongs to the CinA family
AFULGI_RS12260	COG1058	Belongs to the CinA family
AFULGI_RS12265	COG0137	argininosuccinate synthase activity
AFULGI_RS12270	COG1763	Mo-molybdopterin cofactor biosynthetic process
AFULGI_RS12275	COG0513	Belongs to the DEAD box helicase family
AFULGI_RS12280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AFULGI_RS12285	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AFULGI_RS12285	COG0778	Nitroreductase
AFULGI_RS12290	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFULGI_RS12300	COG2814	Major facilitator Superfamily
AFULGI_RS12335	COG2050	protein possibly involved in aromatic compounds catabolism
AFULGI_RS12340	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AFULGI_RS12345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFULGI_RS12350	COG0778	Nitroreductase
AFULGI_RS12360	COG0489	protein tyrosine kinase activity
AFULGI_RS12380	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFULGI_RS12395	COG1573	uracil-dna glycosylase
AFULGI_RS12415	COG2414	aldehyde ferredoxin oxidoreductase
AFULGI_RS12425	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AFULGI_RS12430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AFULGI_RS12435	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AFULGI_RS12440	COG0142	geranyltranstransferase activity
AFULGI_RS12445	COG1304	FMN binding
AFULGI_RS12450	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AFULGI_RS12460	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AFULGI_RS12465	COG0123	including yeast histone deacetylase and acetoin utilization protein
AFULGI_RS12510	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AFULGI_RS12510	COG1213	nucleotidyl transferase
AFULGI_RS12520	COG1945	arginine decarboxylase activity
AFULGI_RS12530	COG0189	ligase activity
AFULGI_RS12565	COG1355	regulation of microtubule-based process
AFULGI_RS12580	COG2030	dehydratase
AFULGI_RS12580	COG1012	belongs to the aldehyde dehydrogenase family
AFULGI_RS12585	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFULGI_RS12590	COG1056	cytidyltransferase-related domain
AFULGI_RS12590	COG1051	belongs to the nudix hydrolase family
AFULGI_RS12595	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AFULGI_RS12625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AFULGI_RS12650	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFULGI_RS12655	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFULGI_RS12660	COG0154	amidase activity
AFULGI_RS12685	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AFULGI_RS12690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AFULGI_RS12725	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFULGI_RS12735	COG0719	Fe-S assembly protein
AFULGI_RS12740	COG0436	Aminotransferase
AFULGI_RS12745	COG0456	acetyltransferase
AFULGI_RS12750	COG0318	PFAM AMP-dependent synthetase and ligase
AFULGI_RS12775	COG0483	inositol monophosphate 1-phosphatase activity
AFULGI_RS12780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AFULGI_RS12805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFULGI_RS12840	COG1111	helicase
AFULGI_RS12840	COG1205	dead DEAH box helicase
AFULGI_RS12845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFULGI_RS12855	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AFULGI_RS12870	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AFULGI_RS12905	COG0784	Response regulator, receiver
AFULGI_RS12915	COG0495	leucyl-tRNA aminoacylation
AFULGI_RS12935	COG0714	Associated with various cellular activities
AFULGI_RS12955	COG1024	Enoyl-CoA hydratase
AFULGI_RS12965	COG1945	arginine decarboxylase activity
AFULGI_RS12980	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AFULGI_RS12985	COG1518	maintenance of DNA repeat elements
AFULGI_RS13020	COG0642	Histidine kinase
AFULGI_RS13025	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AFULGI_RS13065	COG0318	PFAM AMP-dependent synthetase and ligase
AFULGI_RS13070	COG1401	restriction endodeoxyribonuclease activity
AFULGI_RS13075	COG1196	nuclear chromosome segregation
AFULGI_RS13105	COG5002	protein histidine kinase activity
AFULGI_RS13120	COG1378	Sugar-specific transcriptional regulator TrmB
AFULGI_RS13145	COG0318	PFAM AMP-dependent synthetase and ligase
AFULGI_RS13250	COG0640	Transcriptional regulator
AFULGI_RS13255	COG1138	Cytochrome C-type biogenesis protein
AFULGI_RS13260	COG5002	protein histidine kinase activity
AFULGI_RS13325	COG0438	transferase activity, transferring glycosyl groups
AFULGI_RS13345	COG1720	tRNA m6t6A37 methyltransferase activity
AFULGI_RS13360	COG4637	Psort location Cytoplasmic, score
AFULGI_RS13445	COG1429	ligase activity, forming nitrogen-metal bonds
AFULGI_RS13470	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AFULGI_RS13550	COG3335	DDE superfamily endonuclease