locus-tag	class	description
ASULF_RS00030	COG1487	ribonuclease activity
ASULF_RS00060	COG0067	glutamate synthase
ASULF_RS00065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ASULF_RS00070	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ASULF_RS00070	COG0493	'glutamate synthase
ASULF_RS00080	COG1509	lysine 2,3-aminomutase activity
ASULF_RS00085	COG1960	acyl-CoA dehydrogenase activity
ASULF_RS00135	COG0438	transferase activity, transferring glycosyl groups
ASULF_RS00155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ASULF_RS00170	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ASULF_RS00180	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ASULF_RS00185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ASULF_RS00195	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ASULF_RS00200	COG0438	transferase activity, transferring glycosyl groups
ASULF_RS00220	COG0438	transferase activity, transferring glycosyl groups
ASULF_RS00230	COG3408	Glycogen debranching enzyme
ASULF_RS00230	COG3119	arylsulfatase activity
ASULF_RS00235	COG2194	sulfuric ester hydrolase activity
ASULF_RS00240	COG0673	inositol 2-dehydrogenase activity
ASULF_RS00250	COG1028	Short-chain dehydrogenase reductase Sdr
ASULF_RS00290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ASULF_RS00295	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ASULF_RS00340	COG0552	protein localization to endoplasmic reticulum
ASULF_RS00395	COG2255	four-way junction helicase activity
ASULF_RS00400	COG1024	Enoyl-CoA hydratase
ASULF_RS00410	COG5002	protein histidine kinase activity
ASULF_RS00420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ASULF_RS00445	COG0539	negative regulation of cytoplasmic translation
ASULF_RS00480	COG1136	(ABC) transporter
ASULF_RS00505	COG1444	tRNA N-acetyltransferase activity
ASULF_RS00515	COG0535	radical SAM domain protein
ASULF_RS00525	COG1102	Psort location Cytoplasmic, score
ASULF_RS00540	COG0200	Binds to the 23S rRNA
ASULF_RS00550	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ASULF_RS00575	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ASULF_RS00595	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ASULF_RS00600	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ASULF_RS00605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ASULF_RS00615	COG0255	Belongs to the universal ribosomal protein uL29 family
ASULF_RS00620	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ASULF_RS00625	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ASULF_RS00630	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ASULF_RS00640	COG0089	rRNA binding
ASULF_RS00645	COG0088	Forms part of the polypeptide exit tunnel
ASULF_RS00650	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ASULF_RS00660	COG0505	Belongs to the CarA family
ASULF_RS00675	COG0785	Cytochrome C biogenesis protein
ASULF_RS00685	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ASULF_RS00695	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ASULF_RS00700	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASULF_RS00735	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ASULF_RS00765	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ASULF_RS00775	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ASULF_RS00785	COG1078	dGTPase activity
ASULF_RS00790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ASULF_RS00795	COG0084	hydrolase, TatD family'
ASULF_RS00825	COG0284	orotidine-5'-phosphate decarboxylase activity
ASULF_RS00840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ASULF_RS00845	COG1363	Peptidase, m42
ASULF_RS00860	COG0647	UMP catabolic process
ASULF_RS00890	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ASULF_RS00895	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ASULF_RS00900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASULF_RS00915	COG2414	aldehyde ferredoxin oxidoreductase
ASULF_RS00920	COG5002	protein histidine kinase activity
ASULF_RS00945	COG1113	amino acid transport
ASULF_RS00955	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ASULF_RS00955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ASULF_RS00990	COG0039	L-malate dehydrogenase activity
ASULF_RS01010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ASULF_RS01020	COG0174	glutamine synthetase
ASULF_RS01025	COG0163	prenyltransferase activity
ASULF_RS01040	COG1321	iron dependent repressor
ASULF_RS01050	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
ASULF_RS01070	COG2210	Belongs to the sulfur carrier protein TusA family
ASULF_RS01080	COG1252	NADH dehydrogenase
ASULF_RS01090	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
ASULF_RS01095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ASULF_RS01105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ASULF_RS01115	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ASULF_RS01125	COG0688	phosphatidylethanolamine metabolic process
ASULF_RS01150	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ASULF_RS01170	COG3842	ATPase activity
ASULF_RS01190	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ASULF_RS01205	COG2078	PFAM AMMECR1 domain protein
ASULF_RS01210	COG3118	belongs to the thioredoxin family
ASULF_RS01215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASULF_RS01220	COG0585	pseudouridine synthase activity
ASULF_RS01275	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ASULF_RS01295	COG0409	Hydrogenase expression formation protein
ASULF_RS01305	COG1773	rubredoxin
ASULF_RS01305	COG1592	Rubrerythrin
ASULF_RS01320	COG0517	IMP dehydrogenase activity
ASULF_RS01320	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ASULF_RS01355	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
ASULF_RS01360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASULF_RS01380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ASULF_RS01385	COG0045	succinate-CoA ligase (ADP-forming) activity
ASULF_RS01420	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ASULF_RS01425	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ASULF_RS01440	COG1227	inorganic diphosphatase activity
ASULF_RS01445	COG1683	Conserved Protein
ASULF_RS01485	COG2217	Heavy metal translocating P-type atpase
ASULF_RS01495	COG2226	methyltransferase
ASULF_RS01525	COG0640	Transcriptional regulator
ASULF_RS01530	COG2217	Heavy metal translocating P-type atpase
ASULF_RS01550	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ASULF_RS01560	COG0137	argininosuccinate synthase activity
ASULF_RS01580	COG1013	pyruvate-flavodoxin oxidoreductase activity
ASULF_RS01585	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ASULF_RS01585	COG0674	pyruvate-flavodoxin oxidoreductase activity
ASULF_RS01600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ASULF_RS01605	COG0483	inositol monophosphate 1-phosphatase activity
ASULF_RS01610	COG1013	pyruvate-flavodoxin oxidoreductase activity
ASULF_RS01635	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ASULF_RS01640	COG0215	cysteine-tRNA ligase activity
ASULF_RS01650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ASULF_RS01660	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ASULF_RS01665	COG0560	Phosphoserine phosphatase
ASULF_RS01665	COG3830	Belongs to the UPF0237 family
ASULF_RS01675	COG0358	DNA primase activity
ASULF_RS01705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ASULF_RS01745	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ASULF_RS01765	COG2855	membrane
ASULF_RS01775	COG2855	membrane
ASULF_RS01795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ASULF_RS01810	COG1355	regulation of microtubule-based process
ASULF_RS01820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ASULF_RS01840	COG0419	ATPase involved in DNA repair
ASULF_RS01855	COG0433	COG0433 Predicted ATPase
ASULF_RS01860	COG0577	efflux transmembrane transporter activity
ASULF_RS01860	COG1136	(ABC) transporter
ASULF_RS01865	COG1136	(ABC) transporter
ASULF_RS01880	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ASULF_RS01880	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ASULF_RS01885	COG0543	2 iron, 2 sulfur cluster binding
ASULF_RS01890	COG0167	dihydroorotate dehydrogenase activity
ASULF_RS01920	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ASULF_RS01925	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ASULF_RS01935	COG4608	Belongs to the ABC transporter superfamily
ASULF_RS01940	COG0444	Belongs to the ABC transporter superfamily
ASULF_RS01945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASULF_RS01950	COG0601	transmembrane transport
ASULF_RS01955	COG0747	negative chemotaxis
ASULF_RS01995	COG0730	response to heat
ASULF_RS02020	COG0489	protein tyrosine kinase activity
ASULF_RS02060	COG0538	isocitrate dehydrogenase activity
ASULF_RS02065	COG1606	tRNA processing
ASULF_RS02075	COG1691	(AIR) carboxylase
ASULF_RS02080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ASULF_RS02085	COG0505	Belongs to the CarA family
ASULF_RS02095	COG2345	Transcriptional regulator
ASULF_RS02120	COG0281	malic enzyme
ASULF_RS02130	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ASULF_RS02145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ASULF_RS02150	COG0581	inorganic phosphate transmembrane transporter activity
ASULF_RS02155	COG0573	inorganic phosphate transmembrane transporter activity
ASULF_RS02170	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ASULF_RS02175	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ASULF_RS02190	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ASULF_RS02205	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ASULF_RS02205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ASULF_RS02235	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ASULF_RS02245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ASULF_RS02255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ASULF_RS02280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ASULF_RS02290	COG0531	amino acid
ASULF_RS02320	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
ASULF_RS02350	COG0129	dihydroxy-acid dehydratase activity
ASULF_RS02355	COG1378	Sugar-specific transcriptional regulator TrmB
ASULF_RS02365	COG2409	Drug exporters of the RND superfamily
ASULF_RS02365	COG1033	growth of symbiont in host cell
ASULF_RS02385	COG0183	Belongs to the thiolase family
ASULF_RS02395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASULF_RS02415	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ASULF_RS02430	COG1131	(ABC) transporter
ASULF_RS02455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASULF_RS02460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ASULF_RS02485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ASULF_RS02495	COG0142	geranyltranstransferase activity
ASULF_RS02505	COG1324	tolerance protein
ASULF_RS02525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ASULF_RS02535	COG0018	arginyl-trna synthetase
ASULF_RS02540	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASULF_RS02540	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASULF_RS02545	COG0511	ligase activity, forming carbon-carbon bonds
ASULF_RS02550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ASULF_RS02555	COG0346	lactoylglutathione lyase activity
ASULF_RS02560	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASULF_RS02560	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASULF_RS02575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ASULF_RS02575	COG0574	Belongs to the PEP-utilizing enzyme family
ASULF_RS02590	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ASULF_RS02605	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ASULF_RS02610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ASULF_RS02650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASULF_RS02655	COG0142	geranyltranstransferase activity
ASULF_RS02660	COG1304	FMN binding
ASULF_RS02685	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ASULF_RS02705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ASULF_RS02735	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
ASULF_RS02770	COG1469	GTP cyclohydrolase I activity
ASULF_RS02780	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ASULF_RS02785	COG0113	porphobilinogen synthase activity
ASULF_RS02790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ASULF_RS02795	COG0181	hydroxymethylbilane synthase activity
ASULF_RS02800	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASULF_RS02800	COG1648	precorrin-2 dehydrogenase activity
ASULF_RS02810	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ASULF_RS02815	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ASULF_RS02870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ASULF_RS02875	COG2119	membrane
ASULF_RS02915	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
ASULF_RS02925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ASULF_RS02940	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ASULF_RS02965	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
ASULF_RS02985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASULF_RS02995	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ASULF_RS03010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ASULF_RS03015	COG1648	precorrin-2 dehydrogenase activity
ASULF_RS03015	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASULF_RS03045	COG0084	hydrolase, TatD family'
ASULF_RS03060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ASULF_RS03075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ASULF_RS03085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ASULF_RS03095	COG0475	glutathione-regulated potassium exporter activity
ASULF_RS03105	COG0200	Binds to the 23S rRNA
ASULF_RS03115	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ASULF_RS03130	COG0148	phosphopyruvate hydratase activity
ASULF_RS03135	COG0052	Belongs to the universal ribosomal protein uS2 family
ASULF_RS03155	COG0277	FAD linked oxidase domain protein
ASULF_RS03175	COG1139	Iron-sulfur cluster binding protein
ASULF_RS03190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ASULF_RS03200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ASULF_RS03200	COG0512	Glutamine amidotransferase of anthranilate synthase
ASULF_RS03205	COG0135	phosphoribosylanthranilate isomerase activity
ASULF_RS03210	COG0133	tryptophan synthase activity
ASULF_RS03215	COG0159	tryptophan synthase activity
ASULF_RS03220	COG1458	PINc domain ribonuclease
ASULF_RS03225	COG0124	histidyl-tRNA synthetase
ASULF_RS03230	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ASULF_RS03240	COG2855	membrane
ASULF_RS03245	COG0589	response to stress
ASULF_RS03255	COG0671	phosphoesterase, PA-phosphatase related
ASULF_RS03315	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASULF_RS03325	COG3118	belongs to the thioredoxin family
ASULF_RS03335	COG1245	4Fe-4S binding domain
ASULF_RS03335	COG2878	Part of a membrane complex involved in electron transport
ASULF_RS03355	COG0525	valine-tRNA ligase activity
ASULF_RS03395	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ASULF_RS03400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ASULF_RS03425	COG0110	maltose O-acetyltransferase activity
ASULF_RS03430	COG1234	tRNA 3'-trailer cleavage
ASULF_RS03435	COG0051	transcription antitermination factor activity, RNA binding
ASULF_RS03440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASULF_RS03450	COG0049	tRNA binding
ASULF_RS03460	COG0195	Participates in both transcription termination and antitermination
ASULF_RS03470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ASULF_RS03475	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ASULF_RS03480	COG0085	RNA polymerase activity
ASULF_RS03485	COG0085	RNA polymerase activity
ASULF_RS03485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ASULF_RS03510	COG0009	L-threonylcarbamoyladenylate synthase
ASULF_RS03520	COG1073	alpha beta
ASULF_RS03525	COG0563	adenylate kinase activity
ASULF_RS03545	COG0697	spore germination
ASULF_RS03550	COG0352	thiamine-phosphate diphosphorylase activity
ASULF_RS03615	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ASULF_RS03630	COG1891	lyase activity
ASULF_RS03635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ASULF_RS03640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ASULF_RS03645	COG0131	Imidazoleglycerol-phosphate dehydratase
ASULF_RS03650	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ASULF_RS03655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASULF_RS03685	COG1185	polyribonucleotide nucleotidyltransferase activity
ASULF_RS03710	COG1185	polyribonucleotide nucleotidyltransferase activity
ASULF_RS03720	COG5002	protein histidine kinase activity
ASULF_RS03730	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
ASULF_RS03745	COG0477	Major facilitator Superfamily
ASULF_RS03750	COG2814	Major facilitator Superfamily
ASULF_RS03765	COG0778	Nitroreductase
ASULF_RS03770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ASULF_RS03775	COG0430	RNA-3'-phosphate cyclase activity
ASULF_RS03785	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASULF_RS03795	COG0459	protein refolding
ASULF_RS03805	COG1196	nuclear chromosome segregation
ASULF_RS03815	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ASULF_RS03825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ASULF_RS03825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ASULF_RS03830	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ASULF_RS03840	COG0432	Pfam Uncharacterised protein family UPF0047
ASULF_RS03845	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ASULF_RS03855	COG0138	bifunctional purine biosynthesis protein purh
ASULF_RS03865	COG1960	acyl-CoA dehydrogenase activity
ASULF_RS03895	COG1584	GPR1 FUN34 yaaH family protein
ASULF_RS03900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASULF_RS03920	COG0765	amino acid transport
ASULF_RS03925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASULF_RS03945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ASULF_RS03945	COG0519	Catalyzes the synthesis of GMP from XMP
ASULF_RS03950	COG0504	CTP synthase activity
ASULF_RS03960	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ASULF_RS03965	COG0343	queuine tRNA-ribosyltransferase activity
ASULF_RS04000	COG1111	helicase
ASULF_RS04000	COG1205	dead DEAH box helicase
ASULF_RS04005	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASULF_RS04015	COG0303	'Molybdopterin
ASULF_RS04020	COG0303	'Molybdopterin
ASULF_RS04030	COG0351	phosphomethylpyrimidine kinase
ASULF_RS04030	COG0352	thiamine-phosphate diphosphorylase activity
ASULF_RS04035	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ASULF_RS04055	COG0438	transferase activity, transferring glycosyl groups
ASULF_RS04065	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ASULF_RS04080	COG0076	glutamate decarboxylase activity
ASULF_RS04085	COG0390	transport system, permease component
ASULF_RS04090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ASULF_RS04095	COG1695	Transcriptional regulator
ASULF_RS04110	COG0534	Mate efflux family protein
ASULF_RS04115	COG2814	Major facilitator Superfamily
ASULF_RS04140	COG2050	protein possibly involved in aromatic compounds catabolism
ASULF_RS04205	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ASULF_RS04245	COG0116	Belongs to the methyltransferase superfamily
ASULF_RS04255	COG0519	Catalyzes the synthesis of GMP from XMP
ASULF_RS04260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ASULF_RS04260	COG1213	nucleotidyl transferase
ASULF_RS04270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ASULF_RS04285	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ASULF_RS04300	COG1042	CoA-binding domain protein
ASULF_RS04300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ASULF_RS04300	COG0045	succinate-CoA ligase (ADP-forming) activity
ASULF_RS04315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ASULF_RS04330	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ASULF_RS04330	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ASULF_RS04345	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
ASULF_RS04360	COG1013	pyruvate-flavodoxin oxidoreductase activity
ASULF_RS04365	COG0674	pyruvate-flavodoxin oxidoreductase activity
ASULF_RS04390	COG1053	succinate dehydrogenase
ASULF_RS04430	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ASULF_RS04470	COG0126	phosphoglycerate kinase activity
ASULF_RS04500	COG0517	IMP dehydrogenase activity
ASULF_RS04500	COG0516	GMP reductase activity
ASULF_RS04505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASULF_RS04515	COG1615	UPF0182 protein
ASULF_RS04530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ASULF_RS04545	COG2221	Nitrite and sulphite reductase 4Fe-4S
ASULF_RS04550	COG2221	Nitrite and sulphite reductase 4Fe-4S
ASULF_RS04555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASULF_RS04575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ASULF_RS04595	COG0444	Belongs to the ABC transporter superfamily
ASULF_RS04605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASULF_RS04610	COG0601	transmembrane transport
ASULF_RS04615	COG0747	negative chemotaxis
ASULF_RS04625	COG2226	methyltransferase
ASULF_RS04630	COG0347	Belongs to the P(II) protein family
ASULF_RS04635	COG0004	ammonium transporteR
ASULF_RS04650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASULF_RS04665	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ASULF_RS04670	COG1830	Aldolase
ASULF_RS04820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASULF_RS04820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASULF_RS04825	COG0517	IMP dehydrogenase activity
ASULF_RS04825	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ASULF_RS04830	COG0077	Prephenate dehydratase
ASULF_RS04830	COG1605	Chorismate mutase
ASULF_RS04840	COG1465	3-dehydroquinate synthase
ASULF_RS04845	COG1830	Aldolase
ASULF_RS04850	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ASULF_RS04855	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
ASULF_RS04895	COG0436	Aminotransferase
ASULF_RS04905	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ASULF_RS04910	COG1160	GTP binding
ASULF_RS04930	COG1573	uracil-dna glycosylase
ASULF_RS04945	COG0165	Argininosuccinate lyase
ASULF_RS04950	COG0252	asparaginase activity
ASULF_RS04960	COG2264	protein methyltransferase activity
ASULF_RS04970	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ASULF_RS05005	COG1185	polyribonucleotide nucleotidyltransferase activity
ASULF_RS05010	COG0140	phosphoribosyl-ATP diphosphatase activity
ASULF_RS05010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ASULF_RS05025	COG0314	molybdopterin synthase activity
ASULF_RS05040	COG0109	protoheme IX farnesyltransferase activity
ASULF_RS05050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASULF_RS05085	COG4191	Histidine kinase
ASULF_RS05090	COG2855	membrane
ASULF_RS05110	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ASULF_RS05115	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ASULF_RS05125	COG0531	amino acid
ASULF_RS05130	COG0668	transmembrane transport
ASULF_RS05160	COG0714	Associated with various cellular activities
ASULF_RS05190	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ASULF_RS05195	COG1227	inorganic diphosphatase activity
ASULF_RS05205	COG0306	phosphate transporter
ASULF_RS05215	COG1126	abc transporter atp-binding protein
ASULF_RS05235	COG1335	isochorismatase
ASULF_RS05240	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ASULF_RS05265	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ASULF_RS05270	COG0587	DNA-directed DNA polymerase activity
ASULF_RS05290	COG0528	UMP kinase activity
ASULF_RS05295	COG0495	leucyl-tRNA aminoacylation
ASULF_RS05300	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ASULF_RS05305	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ASULF_RS05335	COG3259	Nickel-dependent hydrogenase
ASULF_RS05350	COG2048	Heterodisulfide reductase, subunit B
ASULF_RS05365	COG0589	response to stress
ASULF_RS05390	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
ASULF_RS05395	COG0149	triose-phosphate isomerase activity
ASULF_RS05400	COG0473	3-isopropylmalate dehydrogenase activity
ASULF_RS05405	COG0066	3-isopropylmalate dehydratase activity
ASULF_RS05410	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ASULF_RS05415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ASULF_RS05425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ASULF_RS05470	COG1216	Glycosyl transferase, family 2
ASULF_RS05485	COG0297	glycogen (starch) synthase activity
ASULF_RS05485	COG0438	transferase activity, transferring glycosyl groups
ASULF_RS05500	COG0471	metal ion transport
ASULF_RS05510	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ASULF_RS05540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ASULF_RS05565	COG3290	protein histidine kinase activity
ASULF_RS05570	COG0183	Belongs to the thiolase family
ASULF_RS05575	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ASULF_RS05580	COG4145	pantothenate transmembrane transporter activity
ASULF_RS05585	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ASULF_RS05595	COG1047	Peptidyl-prolyl cis-trans
ASULF_RS05600	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ASULF_RS05615	COG0154	amidase activity
ASULF_RS05620	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ASULF_RS05625	COG1515	deoxyribonuclease V activity
ASULF_RS05630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ASULF_RS05645	COG1231	oxidoreductase activity
ASULF_RS05660	COG1882	Formate acetyltransferase
ASULF_RS05710	COG3794	PFAM blue (type 1) copper domain protein
ASULF_RS05730	COG0561	phosphatase activity
ASULF_RS05735	COG1960	acyl-CoA dehydrogenase activity
ASULF_RS05740	COG0318	PFAM AMP-dependent synthetase and ligase
ASULF_RS05770	COG1598	PFAM Uncharacterised protein family UPF0150
ASULF_RS05800	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ASULF_RS05830	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ASULF_RS05875	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASULF_RS05880	COG1024	Enoyl-CoA hydratase
ASULF_RS05885	COG1960	acyl-CoA dehydrogenase activity
ASULF_RS05895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASULF_RS05905	COG0655	NAD(P)H dehydrogenase (quinone) activity
ASULF_RS05920	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ASULF_RS05925	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASULF_RS05930	COG1522	sequence-specific DNA binding
ASULF_RS05935	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ASULF_RS05940	COG0540	Belongs to the ATCase OTCase family
ASULF_RS05950	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ASULF_RS05970	COG4145	pantothenate transmembrane transporter activity
ASULF_RS05980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ASULF_RS05985	COG1201	RNA secondary structure unwinding
ASULF_RS06015	COG2033	superoxide reductase activity
ASULF_RS06020	COG2201	protein-glutamate methylesterase activity
ASULF_RS06055	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ASULF_RS06080	COG1151	hydroxylamine reductase activity
ASULF_RS06120	COG4608	Belongs to the ABC transporter superfamily
ASULF_RS06125	COG0444	Belongs to the ABC transporter superfamily
ASULF_RS06130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASULF_RS06135	COG0601	transmembrane transport
ASULF_RS06140	COG0747	negative chemotaxis
ASULF_RS06150	COG1518	maintenance of DNA repeat elements
ASULF_RS06155	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ASULF_RS06165	COG1203	CRISPR-associated helicase, Cas3
ASULF_RS06215	COG0426	domain, Protein
ASULF_RS06225	COG1960	acyl-CoA dehydrogenase activity
ASULF_RS06230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ASULF_RS06245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ASULF_RS06255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASULF_RS06275	COG2201	protein-glutamate methylesterase activity
ASULF_RS06310	COG1268	BioY protein
ASULF_RS06315	COG4172	Belongs to the ABC transporter superfamily
ASULF_RS06325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ASULF_RS06335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ASULF_RS06370	COG0107	imidazoleglycerol-phosphate synthase activity
ASULF_RS06375	COG1254	Belongs to the acylphosphatase family
ASULF_RS06390	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ASULF_RS06475	COG1846	Transcriptional regulator
ASULF_RS06650	COG0546	phosphoglycolate phosphatase activity
ASULF_RS06665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ASULF_RS06695	COG0514	ATP-dependent DNA helicase (RecQ)
ASULF_RS06710	COG4637	Psort location Cytoplasmic, score
ASULF_RS06740	COG1074	ATP-dependent DNA helicase activity
ASULF_RS06765	COG0827	DNA restriction-modification system
ASULF_RS06785	COG1598	PFAM Uncharacterised protein family UPF0150
ASULF_RS06965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASULF_RS06970	COG1960	acyl-CoA dehydrogenase activity
ASULF_RS06990	COG1372	Participates in initiation and elongation during chromosome replication
ASULF_RS06990	COG0719	Fe-S assembly protein
ASULF_RS07010	COG1960	acyl-CoA dehydrogenase activity
ASULF_RS07015	COG0183	Belongs to the thiolase family
ASULF_RS07025	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASULF_RS07055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASULF_RS07200	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ASULF_RS07225	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ASULF_RS07230	COG0315	cyclic pyranopterin monophosphate synthase activity
ASULF_RS07235	COG0277	FAD linked oxidase domain protein
ASULF_RS07240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ASULF_RS07540	COG0037	tRNA processing
ASULF_RS07565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ASULF_RS07570	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ASULF_RS07575	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ASULF_RS07575	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ASULF_RS07590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASULF_RS07595	COG0492	ferredoxin-NADP+ reductase activity
ASULF_RS07605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ASULF_RS07610	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
ASULF_RS07610	COG0778	Nitroreductase
ASULF_RS07615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ASULF_RS07620	COG3118	belongs to the thioredoxin family
ASULF_RS07625	COG0301	tRNA thio-modification
ASULF_RS07630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ASULF_RS07630	COG1773	rubredoxin
ASULF_RS07640	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ASULF_RS07645	COG1793	dna ligase
ASULF_RS07650	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ASULF_RS07660	COG0010	Belongs to the arginase family
ASULF_RS07665	COG1592	Rubrerythrin
ASULF_RS07675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ASULF_RS07680	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ASULF_RS07695	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ASULF_RS07715	COG0006	proline dipeptidase activity
ASULF_RS07725	COG0747	negative chemotaxis
ASULF_RS07730	COG0601	transmembrane transport
ASULF_RS07735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASULF_RS07740	COG0444	Belongs to the ABC transporter superfamily
ASULF_RS07745	COG4608	Belongs to the ABC transporter superfamily
ASULF_RS07750	COG0017	Asparaginyl-tRNA synthetase
ASULF_RS07755	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ASULF_RS07795	COG1229	Formylmethanofuran dehydrogenase subunit A
ASULF_RS07810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ASULF_RS07815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ASULF_RS07820	COG0183	Belongs to the thiolase family
ASULF_RS07830	COG1960	acyl-CoA dehydrogenase activity
ASULF_RS07835	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASULF_RS07865	COG2442	InterPro IPR007367
ASULF_RS07905	COG0442	prolyl-tRNA aminoacylation
ASULF_RS07920	COG1945	arginine decarboxylase activity
ASULF_RS07925	COG0531	amino acid
ASULF_RS07930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ASULF_RS07940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ASULF_RS07950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ASULF_RS07965	COG1793	dna ligase
ASULF_RS07980	COG2181	nitrate reductase activity
ASULF_RS07980	COG0247	lactate metabolic process
ASULF_RS07990	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ASULF_RS07995	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ASULF_RS08005	COG0583	DNA-binding transcription factor activity
ASULF_RS08050	COG1993	acr, cog1993
ASULF_RS08055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ASULF_RS08065	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASULF_RS08080	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ASULF_RS08085	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ASULF_RS08090	COG1763	Mo-molybdopterin cofactor biosynthetic process
ASULF_RS08100	COG0460	homoserine dehydrogenase
ASULF_RS08110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ASULF_RS08125	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ASULF_RS08130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASULF_RS08140	COG5002	protein histidine kinase activity
ASULF_RS08155	COG0318	PFAM AMP-dependent synthetase and ligase
ASULF_RS08180	COG5002	protein histidine kinase activity
ASULF_RS08190	COG2890	protein-(glutamine-N5) methyltransferase activity
ASULF_RS08195	COG0864	Transcriptional regulator
ASULF_RS08210	COG1522	sequence-specific DNA binding
ASULF_RS08215	COG1794	racemase activity, acting on amino acids and derivatives
ASULF_RS08220	COG2181	nitrate reductase activity
ASULF_RS08220	COG0247	lactate metabolic process
ASULF_RS08225	COG0028	Belongs to the TPP enzyme family
ASULF_RS08230	COG0440	acetolactate synthase activity
ASULF_RS08240	COG1067	ATP-dependent peptidase activity
ASULF_RS08240	COG0470	DNA polymerase III
ASULF_RS08245	COG0312	modulator of DNA gyrase
ASULF_RS08275	COG0463	Glycosyl transferase, family 2
ASULF_RS08305	COG0826	peptidase U32
ASULF_RS08320	COG5002	protein histidine kinase activity
ASULF_RS08330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ASULF_RS08350	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASULF_RS08350	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASULF_RS08355	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASULF_RS08355	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASULF_RS08390	COG0805	protein transport
ASULF_RS08395	COG0569	domain protein
ASULF_RS08415	COG1024	Enoyl-CoA hydratase
ASULF_RS08480	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ASULF_RS08485	COG0649	NAD binding
ASULF_RS08490	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASULF_RS08505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ASULF_RS08510	COG0651	ATP synthesis coupled electron transport
ASULF_RS08535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASULF_RS08540	COG0247	lactate metabolic process
ASULF_RS08540	COG2181	nitrate reductase activity
ASULF_RS08560	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ASULF_RS08580	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ASULF_RS08585	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ASULF_RS08600	COG0019	diaminopimelate decarboxylase activity
ASULF_RS08605	COG0436	Aminotransferase
ASULF_RS08610	COG0372	Belongs to the citrate synthase family
ASULF_RS08625	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ASULF_RS08630	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ASULF_RS08635	COG0047	phosphoribosylformylglycinamidine synthase activity
ASULF_RS08640	COG0730	response to heat
ASULF_RS08710	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ASULF_RS08715	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ASULF_RS08755	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASULF_RS08760	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASULF_RS08765	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASULF_RS08775	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ASULF_RS08780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASULF_RS08790	COG0713	ATP synthesis coupled electron transport
ASULF_RS08795	COG0651	ATP synthesis coupled electron transport
ASULF_RS08805	COG0651	ATP synthesis coupled electron transport
ASULF_RS08815	COG1007	ATP synthesis coupled electron transport
ASULF_RS08840	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASULF_RS08860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ASULF_RS08860	COG1017	nitric oxide dioxygenase activity
ASULF_RS08875	COG0516	GMP reductase activity
ASULF_RS08875	COG0517	IMP dehydrogenase activity
ASULF_RS08925	COG1138	Cytochrome C-type biogenesis protein
ASULF_RS08930	COG2339	peptidase activity
ASULF_RS08935	COG4399	Belongs to the UPF0754 family
ASULF_RS08955	COG0247	lactate metabolic process
ASULF_RS08955	COG2181	nitrate reductase activity
ASULF_RS08965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASULF_RS08975	COG0517	IMP dehydrogenase activity
ASULF_RS08975	COG1994	Peptidase M50
ASULF_RS09000	COG0180	Tryptophanyl-tRNA synthetase
ASULF_RS09010	COG1615	UPF0182 protein
ASULF_RS09025	COG0805	protein transport
ASULF_RS09030	COG2414	aldehyde ferredoxin oxidoreductase
ASULF_RS09055	COG0410	ABC transporter
ASULF_RS09075	COG2201	protein-glutamate methylesterase activity
ASULF_RS09100	COG2373	Large extracellular alpha-helical protein
ASULF_RS09105	COG1404	Belongs to the peptidase S8 family
ASULF_RS09110	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ASULF_RS09130	COG1122	ATPase activity
ASULF_RS09145	COG0310	cobalt ion transport
ASULF_RS09150	COG0436	Aminotransferase
ASULF_RS09160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASULF_RS09165	COG0101	tRNA pseudouridine synthase activity
ASULF_RS09175	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ASULF_RS09195	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ASULF_RS09215	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ASULF_RS09230	COG0066	3-isopropylmalate dehydratase activity
ASULF_RS09245	COG0443	Heat shock 70 kDa protein
ASULF_RS09260	COG2814	Major facilitator Superfamily
ASULF_RS09270	COG2095	MarC family integral membrane protein
ASULF_RS09280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ASULF_RS09295	COG1131	(ABC) transporter
ASULF_RS09365	COG0529	Catalyzes the synthesis of activated sulfate
ASULF_RS09425	COG0318	PFAM AMP-dependent synthetase and ligase
ASULF_RS09430	COG0187	DNA topoisomerase II activity
ASULF_RS09435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ASULF_RS09440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASULF_RS09460	COG2358	TRAP transporter, solute receptor (TAXI family
ASULF_RS09510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ASULF_RS09515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASULF_RS09535	COG0003	Pfam Anion-transporting ATPase
ASULF_RS09550	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ASULF_RS09560	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
ASULF_RS09565	COG1234	tRNA 3'-trailer cleavage
ASULF_RS09585	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ASULF_RS09595	COG0330	HflC and HflK could
ASULF_RS09600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ASULF_RS09615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ASULF_RS09620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ASULF_RS09625	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ASULF_RS09630	COG1850	ribulose-bisphosphate carboxylase activity
ASULF_RS09635	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ASULF_RS09640	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ASULF_RS09680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ASULF_RS09695	COG1522	sequence-specific DNA binding
ASULF_RS09700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ASULF_RS09710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ASULF_RS09715	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ASULF_RS09725	COG1183	phosphatidylcholine synthase activity
ASULF_RS09755	COG1811	Na channel or pump
ASULF_RS09760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ASULF_RS09795	COG1899	peptidyl-lysine modification to peptidyl-hypusine
ASULF_RS09810	COG0371	Dehydrogenase
ASULF_RS09815	COG0501	Belongs to the peptidase M48B family
ASULF_RS09835	COG0154	amidase activity
ASULF_RS09890	COG0427	acetyl-CoA hydrolase
ASULF_RS09950	COG1522	sequence-specific DNA binding
ASULF_RS09955	COG4948	Mandelate Racemase Muconate Lactonizing
ASULF_RS10000	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ASULF_RS10030	COG0081	regulation of translation
ASULF_RS10035	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ASULF_RS10045	COG0439	Biotin carboxylase
ASULF_RS10055	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ASULF_RS10070	COG1378	Sugar-specific transcriptional regulator TrmB
ASULF_RS10075	COG1088	dTDP-glucose 4,6-dehydratase activity
ASULF_RS10085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ASULF_RS10090	COG1331	Highly conserved protein containing a thioredoxin domain
ASULF_RS10100	COG0004	ammonium transporteR
ASULF_RS10105	COG0347	Belongs to the P(II) protein family
ASULF_RS10110	COG0004	ammonium transporteR
ASULF_RS10135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASULF_RS10145	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ASULF_RS10150	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ASULF_RS10180	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ASULF_RS10200	COG0708	Exodeoxyribonuclease III
ASULF_RS10215	COG1079	Belongs to the binding-protein-dependent transport system permease family
ASULF_RS10220	COG4603	Belongs to the binding-protein-dependent transport system permease family
ASULF_RS10225	COG3845	ABC transporter
ASULF_RS10230	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ASULF_RS10245	COG0521	Mo-molybdopterin cofactor biosynthetic process
ASULF_RS10265	COG2264	protein methyltransferase activity
ASULF_RS10280	COG1233	COG1233 Phytoene dehydrogenase and related
ASULF_RS10315	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ASULF_RS10320	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ASULF_RS10325	COG0535	radical SAM domain protein
ASULF_RS10340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASULF_RS10350	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ASULF_RS10385	COG2414	aldehyde ferredoxin oxidoreductase
ASULF_RS10390	COG0778	Nitroreductase
ASULF_RS10400	COG1418	mRNA catabolic process
ASULF_RS10405	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASULF_RS10415	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASULF_RS10430	COG0247	lactate metabolic process
ASULF_RS10470	COG1121	(ABC) transporter
ASULF_RS10475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ASULF_RS10480	COG0151	Belongs to the GarS family
ASULF_RS10485	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASULF_RS10485	COG1902	pentaerythritol trinitrate reductase activity
ASULF_RS10515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASULF_RS10520	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ASULF_RS10520	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ASULF_RS10540	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ASULF_RS10545	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ASULF_RS10565	COG1201	RNA secondary structure unwinding
ASULF_RS10570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ASULF_RS10620	COG2201	protein-glutamate methylesterase activity
ASULF_RS10630	COG0516	GMP reductase activity
ASULF_RS10630	COG0517	IMP dehydrogenase activity
ASULF_RS10635	COG0517	IMP dehydrogenase activity
ASULF_RS10650	COG2414	aldehyde ferredoxin oxidoreductase
ASULF_RS10675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASULF_RS10685	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ASULF_RS10700	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
ASULF_RS10705	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
ASULF_RS10755	COG0489	protein tyrosine kinase activity
ASULF_RS10760	COG1342	Belongs to the UPF0251 family
ASULF_RS10800	COG5002	protein histidine kinase activity
ASULF_RS10810	COG0084	hydrolase, TatD family'
ASULF_RS10820	COG0045	succinate-CoA ligase (ADP-forming) activity
ASULF_RS10825	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ASULF_RS10830	COG1053	succinate dehydrogenase
ASULF_RS10850	COG2985	domain, Protein
ASULF_RS10850	COG0569	domain protein
ASULF_RS10880	COG1185	polyribonucleotide nucleotidyltransferase activity
ASULF_RS10885	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ASULF_RS10900	COG1773	rubredoxin
ASULF_RS10915	COG1492	cobalamin metabolic process
ASULF_RS10935	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ASULF_RS10940	COG1122	ATPase activity
ASULF_RS10960	COG2264	protein methyltransferase activity
ASULF_RS10970	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ASULF_RS10975	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ASULF_RS11000	COG1110	DNA topoisomerase II activity
ASULF_RS11030	COG0105	UTP biosynthetic process
ASULF_RS11035	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ASULF_RS11035	COG3266	domain, Protein
ASULF_RS11045	COG2226	methyltransferase
ASULF_RS11055	COG0857	belongs to the CobB CobQ family
ASULF_RS11090	COG0746	molybdenum cofactor guanylyltransferase activity
ASULF_RS11095	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ASULF_RS11115	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ASULF_RS11120	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ASULF_RS11155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ASULF_RS11160	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ASULF_RS11190	COG0437	4 iron, 4 sulfur cluster binding
ASULF_RS11195	COG2920	part of a sulfur-relay system
ASULF_RS11235	COG1980	fructose-bisphosphate aldolase activity
ASULF_RS11280	COG1620	l-lactate permease
ASULF_RS11285	COG1620	l-lactate permease
ASULF_RS11290	COG0784	Response regulator, receiver
ASULF_RS11325	COG1401	restriction endodeoxyribonuclease activity
ASULF_RS11330	COG1525	nuclease
ASULF_RS11390	COG2340	Cysteine-rich secretory protein family
ASULF_RS11400	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ASULF_RS11405	COG3290	protein histidine kinase activity
ASULF_RS11415	COG5002	protein histidine kinase activity
ASULF_RS11550	COG1598	PFAM Uncharacterised protein family UPF0150
ASULF_RS11585	COG0463	Glycosyl transferase, family 2