locus-tag	class	description
AA314_RS00025	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_RS00025	COG2319	Wd-40 repeat
AA314_RS00035	COG0243	molybdopterin cofactor binding
AA314_RS00130	COG2124	cytochrome p450
AA314_RS00135	COG2124	cytochrome p450
AA314_RS00160	COG0456	acetyltransferase
AA314_RS00170	COG1131	(ABC) transporter
AA314_RS00180	COG1131	(ABC) transporter
AA314_RS00185	COG1725	Transcriptional regulator
AA314_RS00265	COG0515	serine threonine protein kinase
AA314_RS00265	COG2815	serine threonine protein kinase
AA314_RS00295	COG1404	Belongs to the peptidase S8 family
AA314_RS00305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA314_RS00335	COG1902	pentaerythritol trinitrate reductase activity
AA314_RS00355	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AA314_RS00380	COG1595	DNA-templated transcription, initiation
AA314_RS00390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AA314_RS00390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AA314_RS00395	COG1404	Belongs to the peptidase S8 family
AA314_RS00400	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AA314_RS00495	COG2311	Membrane
AA314_RS00510	COG0242	peptide deformylase activity
AA314_RS00565	COG1672	PFAM Archaeal ATPase
AA314_RS00565	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA314_RS00595	COG3852	Histidine kinase
AA314_RS00655	COG0625	glutathione transferase activity
AA314_RS00660	COG2223	nitrite transmembrane transporter activity
AA314_RS00675	COG2814	Major facilitator Superfamily
AA314_RS00740	COG0745	RESPONSE REGULATOR receiver
AA314_RS00825	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AA314_RS00830	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AA314_RS00835	COG0235	Class ii aldolase
AA314_RS00845	COG5002	protein histidine kinase activity
AA314_RS00860	COG0003	Pfam Anion-transporting ATPase
AA314_RS00915	COG5002	protein histidine kinase activity
AA314_RS00915	COG0784	Response regulator, receiver
AA314_RS00935	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AA314_RS00960	COG0535	radical SAM domain protein
AA314_RS00980	COG5002	protein histidine kinase activity
AA314_RS01025	COG3483	tryptophan 2,3-dioxygenase activity
AA314_RS01045	COG2267	carboxylic ester hydrolase activity
AA314_RS01050	COG0506	proline dehydrogenase activity
AA314_RS01060	COG1695	Transcriptional regulator
AA314_RS01110	COG0604	alcohol dehydrogenase
AA314_RS01115	COG1739	Uncharacterized protein family UPF0029
AA314_RS01150	COG4221	oxidoreductase activity
AA314_RS01220	COG0243	molybdopterin cofactor binding
AA314_RS01220	COG3383	formate dehydrogenase (NAD+) activity
AA314_RS01225	COG0437	4 iron, 4 sulfur cluster binding
AA314_RS01235	COG0277	FAD linked oxidase domain protein
AA314_RS01270	COG1876	peptidase activity
AA314_RS01285	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS01295	COG0583	DNA-binding transcription factor activity
AA314_RS01300	COG3384	dioxygenase
AA314_RS01315	COG1763	Mo-molybdopterin cofactor biosynthetic process
AA314_RS01320	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AA314_RS01330	COG1234	tRNA 3'-trailer cleavage
AA314_RS01350	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AA314_RS01395	COG3268	Saccharopine dehydrogenase
AA314_RS01410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA314_RS01470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA314_RS01475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AA314_RS01485	COG1024	Enoyl-CoA hydratase
AA314_RS01495	COG2124	cytochrome p450
AA314_RS01515	COG0784	Response regulator, receiver
AA314_RS01515	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA314_RS01540	COG0714	Associated with various cellular activities
AA314_RS01550	COG0483	inositol monophosphate 1-phosphatase activity
AA314_RS01575	COG3584	3D domain protein
AA314_RS01575	COG1388	LysM domain
AA314_RS01620	COG3290	protein histidine kinase activity
AA314_RS01620	COG0840	transmembrane signaling receptor activity
AA314_RS01625	COG0656	L-ascorbic acid biosynthetic process
AA314_RS01650	COG3034	peptidoglycan biosynthetic process
AA314_RS01685	COG0697	spore germination
AA314_RS01715	COG1940	carbohydrate kinase activity
AA314_RS01725	COG1899	peptidyl-lysine modification to peptidyl-hypusine
AA314_RS01790	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA314_RS01870	COG1845	cytochrome c oxidase, subunit III
AA314_RS01870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA314_RS01905	COG0437	4 iron, 4 sulfur cluster binding
AA314_RS01940	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AA314_RS01955	COG0405	Gamma-glutamyltransferase
AA314_RS01970	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA314_RS01975	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AA314_RS01980	COG2186	Transcriptional regulator
AA314_RS01995	COG3174	membrane
AA314_RS02010	COG1475	DNA binding
AA314_RS02015	COG1192	Involved in chromosome partitioning
AA314_RS02030	COG4191	Histidine kinase
AA314_RS02035	COG0357	Ribosomal RNA small subunit methyltransferase G
AA314_RS02040	COG0445	tRNA wobble uridine modification
AA314_RS02055	COG2226	methyltransferase
AA314_RS02090	COG0612	Peptidase, M16
AA314_RS02095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA314_RS02105	COG2267	carboxylic ester hydrolase activity
AA314_RS02110	COG0616	signal peptide processing
AA314_RS02165	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AA314_RS02190	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AA314_RS02195	COG0594	ribonuclease P activity
AA314_RS02200	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AA314_RS02205	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AA314_RS02250	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AA314_RS02275	COG2124	cytochrome p450
AA314_RS02280	COG2226	methyltransferase
AA314_RS02285	COG4191	Histidine kinase
AA314_RS02355	COG1733	regulation of RNA biosynthetic process
AA314_RS02360	COG0702	epimerase
AA314_RS02375	COG2814	Major facilitator Superfamily
AA314_RS02385	COG2843	Capsule synthesis protein
AA314_RS02455	COG0477	Major facilitator Superfamily
AA314_RS02460	COG0583	DNA-binding transcription factor activity
AA314_RS02465	COG3214	Protein conserved in bacteria
AA314_RS02495	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AA314_RS02510	COG3005	denitrification pathway
AA314_RS02515	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AA314_RS02530	COG0189	ligase activity
AA314_RS02550	COG0515	serine threonine protein kinase
AA314_RS02580	COG1562	ergosterol biosynthetic process
AA314_RS02585	COG0667	Aldo Keto reductase
AA314_RS02590	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA314_RS02600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_RS02610	COG0515	serine threonine protein kinase
AA314_RS02675	COG0515	serine threonine protein kinase
AA314_RS02720	COG3387	PFAM Glycoside hydrolase 15-related
AA314_RS02730	COG3220	belongs to the UPF0276 family
AA314_RS02740	COG2319	Wd-40 repeat
AA314_RS02740	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_RS02745	COG4804	nuclease activity
AA314_RS02750	COG0702	epimerase
AA314_RS02820	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AA314_RS02875	COG1994	Peptidase M50
AA314_RS02885	COG2234	aminopeptidase activity
AA314_RS02975	COG1690	Belongs to the RtcB family
AA314_RS02985	COG1819	glycosyl
AA314_RS03005	COG0515	serine threonine protein kinase
AA314_RS03005	COG2815	serine threonine protein kinase
AA314_RS03045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA314_RS03080	COG4771	TonB-dependent receptor
AA314_RS03110	COG2815	serine threonine protein kinase
AA314_RS03110	COG0515	serine threonine protein kinase
AA314_RS03125	COG3781	membrane
AA314_RS03135	COG0823	Involved in the tonB-independent uptake of proteins
AA314_RS03135	COG1506	peptidase
AA314_RS03135	COG4946	Tricorn protease homolog
AA314_RS03150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AA314_RS03150	COG2755	lipolytic protein G-D-S-L family
AA314_RS03170	COG0154	amidase activity
AA314_RS03215	COG2815	serine threonine protein kinase
AA314_RS03215	COG0515	serine threonine protein kinase
AA314_RS03230	COG1045	serine acetyltransferase
AA314_RS03235	COG1216	Glycosyl transferase, family 2
AA314_RS03255	COG2239	Acts as a magnesium transporter
AA314_RS03270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AA314_RS03275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA314_RS03280	COG1877	trehalose-phosphatase activity
AA314_RS03280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA314_RS03295	COG2124	cytochrome p450
AA314_RS03305	COG3387	PFAM Glycoside hydrolase 15-related
AA314_RS03315	COG1404	Belongs to the peptidase S8 family
AA314_RS03325	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_RS03335	COG3173	Aminoglycoside phosphotransferase
AA314_RS03355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AA314_RS03385	COG0535	radical SAM domain protein
AA314_RS03390	COG4191	Histidine kinase
AA314_RS03390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA314_RS03405	COG0297	glycogen (starch) synthase activity
AA314_RS03435	COG0281	malic enzyme
AA314_RS03440	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AA314_RS03495	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AA314_RS03500	COG0346	lactoylglutathione lyase activity
AA314_RS03560	COG3540	Alkaline phosphatase
AA314_RS03565	COG1672	PFAM Archaeal ATPase
AA314_RS03565	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA314_RS03570	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AA314_RS03680	COG0673	inositol 2-dehydrogenase activity
AA314_RS03685	COG4191	Histidine kinase
AA314_RS03700	COG5000	phosphorelay sensor kinase activity
AA314_RS03730	COG0596	Alpha beta hydrolase
AA314_RS03770	COG4221	oxidoreductase activity
AA314_RS03805	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AA314_RS03845	COG1309	transcriptional regulator
AA314_RS03850	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AA314_RS03860	COG4191	Histidine kinase
AA314_RS03905	COG4191	Histidine kinase
AA314_RS03910	COG2204	response regulator
AA314_RS03950	COG3228	Belongs to the MtfA family
AA314_RS03955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AA314_RS03965	COG3268	Saccharopine dehydrogenase
AA314_RS03985	COG0730	response to heat
AA314_RS04005	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA314_RS04015	COG0435	Glutathione S-transferase
AA314_RS04120	COG5002	protein histidine kinase activity
AA314_RS04125	COG0784	Response regulator, receiver
AA314_RS04125	COG2205	protein histidine kinase activity
AA314_RS04125	COG5002	protein histidine kinase activity
AA314_RS04135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AA314_RS04140	COG2271	Major facilitator Superfamily
AA314_RS04145	COG0596	Alpha beta hydrolase
AA314_RS04160	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AA314_RS04175	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS04185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA314_RS04190	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_RS04205	COG2267	carboxylic ester hydrolase activity
AA314_RS04270	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AA314_RS04285	COG2137	regulation of response to DNA damage stimulus
AA314_RS04290	COG1960	acyl-CoA dehydrogenase activity
AA314_RS04330	COG0840	transmembrane signaling receptor activity
AA314_RS04340	COG0784	Response regulator, receiver
AA314_RS04340	COG5002	protein histidine kinase activity
AA314_RS04345	COG5002	protein histidine kinase activity
AA314_RS04345	COG0784	Response regulator, receiver
AA314_RS04345	COG2205	protein histidine kinase activity
AA314_RS04430	COG4191	Histidine kinase
AA314_RS04450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA314_RS04455	COG0592	DNA-directed DNA polymerase activity
AA314_RS04465	COG2205	protein histidine kinase activity
AA314_RS04475	COG0515	serine threonine protein kinase
AA314_RS04475	COG2815	serine threonine protein kinase
AA314_RS04495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AA314_RS04500	COG3550	peptidyl-serine autophosphorylation
AA314_RS04510	COG3186	Phenylalanine-4-hydroxylase
AA314_RS04530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA314_RS04540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA314_RS04575	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AA314_RS04580	COG1127	ABC transporter
AA314_RS04600	COG2207	Transcriptional regulator
AA314_RS04605	COG4221	oxidoreductase activity
AA314_RS04630	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS04660	COG3387	PFAM Glycoside hydrolase 15-related
AA314_RS04665	COG4106	trans-aconitate 2-methyltransferase activity
AA314_RS04690	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AA314_RS04735	COG2205	protein histidine kinase activity
AA314_RS04735	COG2202	Pas domain
AA314_RS04740	COG0784	Response regulator, receiver
AA314_RS04750	COG0745	RESPONSE REGULATOR receiver
AA314_RS04770	COG0515	serine threonine protein kinase
AA314_RS04820	COG0848	biopolymer transport protein
AA314_RS04845	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AA314_RS04870	COG0247	lactate metabolic process
AA314_RS04870	COG2181	nitrate reductase activity
AA314_RS04910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA314_RS04945	COG2204	response regulator
AA314_RS04950	COG0515	serine threonine protein kinase
AA314_RS04960	COG4638	Rieske (2fe-2S)
AA314_RS04970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AA314_RS04995	COG2205	protein histidine kinase activity
AA314_RS05010	COG1012	belongs to the aldehyde dehydrogenase family
AA314_RS05050	COG1573	uracil-dna glycosylase
AA314_RS05065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA314_RS05065	COG0784	Response regulator, receiver
AA314_RS05080	COG0484	heat shock protein binding
AA314_RS05085	COG0443	Heat shock 70 kDa protein
AA314_RS05115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA314_RS05120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA314_RS05125	COG2197	response regulator
AA314_RS05170	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS05210	COG0596	Alpha beta hydrolase
AA314_RS05225	COG2124	cytochrome p450
AA314_RS05255	COG0640	Transcriptional regulator
AA314_RS05275	COG1695	Transcriptional regulator
AA314_RS05285	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AA314_RS05290	COG1793	dna ligase
AA314_RS05440	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS05450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA314_RS05475	COG1671	Belongs to the UPF0178 family
AA314_RS05495	COG0784	Response regulator, receiver
AA314_RS05495	COG4191	Histidine kinase
AA314_RS05500	COG0584	glycerophosphoryl diester phosphodiesterase
AA314_RS05505	COG0823	Involved in the tonB-independent uptake of proteins
AA314_RS05505	COG1506	peptidase
AA314_RS05505	COG4946	Tricorn protease homolog
AA314_RS05510	COG0235	Class ii aldolase
AA314_RS05515	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AA314_RS05520	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AA314_RS05525	COG4974	Belongs to the 'phage' integrase family
AA314_RS05530	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS05540	COG0583	DNA-binding transcription factor activity
AA314_RS05590	COG0753	catalase activity
AA314_RS05600	COG2155	Conserved Protein
AA314_RS05605	COG2205	protein histidine kinase activity
AA314_RS05605	COG3437	response regulator, receiver
AA314_RS05605	COG3850	Histidine kinase
AA314_RS05605	COG4999	Histidine kinase
AA314_RS05610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA314_RS05660	COG0189	ligase activity
AA314_RS05660	COG0569	domain protein
AA314_RS05665	COG2204	response regulator
AA314_RS05690	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AA314_RS05695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AA314_RS05705	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AA314_RS05710	COG4221	oxidoreductase activity
AA314_RS05745	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AA314_RS05750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AA314_RS05755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AA314_RS05765	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AA314_RS05795	COG1846	Transcriptional regulator
AA314_RS05800	COG2329	Antibiotic biosynthesis monooxygenase
AA314_RS05820	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AA314_RS05825	COG0515	serine threonine protein kinase
AA314_RS05830	COG1366	Belongs to the anti-sigma-factor antagonist family
AA314_RS05835	COG1366	Belongs to the anti-sigma-factor antagonist family
AA314_RS05840	COG2172	sigma factor antagonist activity
AA314_RS05860	COG3409	Peptidoglycan-binding domain 1 protein
AA314_RS05860	COG3773	Cell wall hydrolase
AA314_RS05865	COG0667	Aldo Keto reductase
AA314_RS05895	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AA314_RS05925	COG1515	deoxyribonuclease V activity
AA314_RS05930	COG0596	Alpha beta hydrolase
AA314_RS05955	COG0515	serine threonine protein kinase
AA314_RS05955	COG0457	Tetratricopeptide repeat
AA314_RS05965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA314_RS06005	COG2010	Cytochrome c
AA314_RS06095	COG1595	DNA-templated transcription, initiation
AA314_RS06125	COG3852	Histidine kinase
AA314_RS06130	COG1881	PFAM PEBP family protein
AA314_RS06170	COG0356	it plays a direct role in the translocation of protons across the membrane
AA314_RS06180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AA314_RS06185	COG0012	GTP binding
AA314_RS06195	COG0372	Belongs to the citrate synthase family
AA314_RS06200	COG2264	protein methyltransferase activity
AA314_RS06235	COG1408	metallophosphoesterase
AA314_RS06265	COG0667	Aldo Keto reductase
AA314_RS06270	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS06295	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA314_RS06295	COG1672	PFAM Archaeal ATPase
AA314_RS06315	COG0644	oxidoreductase
AA314_RS06340	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AA314_RS06355	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AA314_RS06450	COG4999	Histidine kinase
AA314_RS06450	COG3850	Histidine kinase
AA314_RS06450	COG3437	response regulator, receiver
AA314_RS06450	COG2205	protein histidine kinase activity
AA314_RS06475	COG3852	Histidine kinase
AA314_RS06500	COG0662	Cupin 2, conserved barrel domain protein
AA314_RS06510	COG3844	kynureninase activity
AA314_RS06515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA314_RS06520	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS06565	COG1073	alpha beta
AA314_RS06580	COG0166	Belongs to the GPI family
AA314_RS06610	COG2319	Wd-40 repeat
AA314_RS06610	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_RS06660	COG0346	lactoylglutathione lyase activity
AA314_RS06690	COG0386	Belongs to the glutathione peroxidase family
AA314_RS06710	COG2843	Capsule synthesis protein
AA314_RS06745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA314_RS06750	COG0604	alcohol dehydrogenase
AA314_RS06750	COG3321	synthase
AA314_RS06765	COG3387	PFAM Glycoside hydrolase 15-related
AA314_RS06775	COG1126	abc transporter atp-binding protein
AA314_RS06780	COG0765	amino acid transport
AA314_RS06895	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AA314_RS06900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AA314_RS06905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AA314_RS06930	COG2827	Endonuclease containing a URI domain
AA314_RS06955	COG0602	queuosine metabolic process
AA314_RS06960	COG2816	NAD+ diphosphatase activity
AA314_RS06970	COG1132	(ABC) transporter
AA314_RS06975	COG1132	(ABC) transporter
AA314_RS06995	COG0515	serine threonine protein kinase
AA314_RS07000	COG4771	TonB-dependent receptor
AA314_RS07015	COG0745	RESPONSE REGULATOR receiver
AA314_RS07020	COG0515	serine threonine protein kinase
AA314_RS07020	COG2815	serine threonine protein kinase
AA314_RS07035	COG1360	Flagellar Motor Protein
AA314_RS07080	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_RS07085	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AA314_RS07100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA314_RS07150	COG0436	Aminotransferase
AA314_RS07170	COG0551	DNA topoisomerase type I activity
AA314_RS07170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AA314_RS07180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA314_RS07205	COG0739	heme binding
AA314_RS07205	COG0741	lytic transglycosylase activity
AA314_RS07205	COG1196	nuclear chromosome segregation
AA314_RS07235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AA314_RS07250	COG4191	Histidine kinase
AA314_RS07250	COG0784	Response regulator, receiver
AA314_RS07255	COG2252	PERMEase
AA314_RS07260	COG1278	Cold shock
AA314_RS07325	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AA314_RS07340	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA314_RS07345	COG0515	serine threonine protein kinase
AA314_RS07350	COG0842	Transport permease protein
AA314_RS07355	COG1131	(ABC) transporter
AA314_RS07360	COG0488	(ABC) transporter
AA314_RS07395	COG1525	nuclease
AA314_RS07420	COG0640	Transcriptional regulator
AA314_RS07455	COG1125	glycine betaine transport
AA314_RS07455	COG0517	IMP dehydrogenase activity
AA314_RS07460	COG1174	glycine betaine transport
AA314_RS07475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AA314_RS07475	COG0574	Belongs to the PEP-utilizing enzyme family
AA314_RS07500	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AA314_RS07505	COG1612	heme a metabolic process
AA314_RS07505	COG0109	protoheme IX farnesyltransferase activity
AA314_RS07530	COG1012	belongs to the aldehyde dehydrogenase family
AA314_RS07540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA314_RS07555	COG0671	phosphoesterase, PA-phosphatase related
AA314_RS07580	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA314_RS07595	COG3852	Histidine kinase
AA314_RS07600	COG2204	response regulator
AA314_RS07610	COG0110	maltose O-acetyltransferase activity
AA314_RS07615	COG5002	protein histidine kinase activity
AA314_RS07635	COG3265	gluconokinase activity
AA314_RS07655	COG1309	transcriptional regulator
AA314_RS07665	COG4191	Histidine kinase
AA314_RS07725	COG1192	Involved in chromosome partitioning
AA314_RS07755	COG1131	(ABC) transporter
AA314_RS07800	COG2205	protein histidine kinase activity
AA314_RS07815	COG5002	protein histidine kinase activity
AA314_RS07835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA314_RS07850	COG1764	response to oxidative stress
AA314_RS07860	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA314_RS07890	COG0515	serine threonine protein kinase
AA314_RS07895	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AA314_RS07920	COG0596	Alpha beta hydrolase
AA314_RS07935	COG1234	tRNA 3'-trailer cleavage
AA314_RS07945	COG1309	transcriptional regulator
AA314_RS07950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA314_RS07985	COG1278	Cold shock
AA314_RS08000	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AA314_RS08010	COG2031	fatty acid transporter
AA314_RS08025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AA314_RS08045	COG2197	response regulator
AA314_RS08055	COG2205	protein histidine kinase activity
AA314_RS08055	COG3850	Histidine kinase
AA314_RS08055	COG3437	response regulator, receiver
AA314_RS08055	COG4999	Histidine kinase
AA314_RS08075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA314_RS08080	COG2205	protein histidine kinase activity
AA314_RS08100	COG1132	(ABC) transporter
AA314_RS08110	COG0484	heat shock protein binding
AA314_RS08120	COG0515	serine threonine protein kinase
AA314_RS08210	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AA314_RS08220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AA314_RS08240	COG0644	oxidoreductase
AA314_RS08285	COG2130	NADP-dependent
AA314_RS08340	COG0438	transferase activity, transferring glycosyl groups
AA314_RS08350	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AA314_RS08355	COG0583	DNA-binding transcription factor activity
AA314_RS08365	COG1074	ATP-dependent DNA helicase activity
AA314_RS08430	COG3227	Zinc metalloprotease (Elastase)
AA314_RS08450	COG1960	acyl-CoA dehydrogenase activity
AA314_RS08470	COG4772	TonB-dependent receptor
AA314_RS08480	COG4251	negative regulation of phosphorylation
AA314_RS08485	COG0784	Response regulator, receiver
AA314_RS08490	COG5002	protein histidine kinase activity
AA314_RS08530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AA314_RS08530	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA314_RS08535	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AA314_RS08540	COG4242	Belongs to the peptidase S51 family
AA314_RS08560	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS08575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AA314_RS08630	COG1605	Chorismate mutase
AA314_RS08630	COG0287	Prephenate dehydrogenase
AA314_RS08640	COG0826	peptidase U32
AA314_RS08655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA314_RS08675	COG2124	cytochrome p450
AA314_RS08700	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA314_RS08760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA314_RS08765	COG1522	sequence-specific DNA binding
AA314_RS08845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_RS08870	COG2234	aminopeptidase activity
AA314_RS08875	COG0242	peptide deformylase activity
AA314_RS08890	COG0443	Heat shock 70 kDa protein
AA314_RS08905	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AA314_RS08915	COG0625	glutathione transferase activity
AA314_RS08925	COG0783	Belongs to the Dps family
AA314_RS08930	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AA314_RS09030	COG1309	transcriptional regulator
AA314_RS09035	COG1408	metallophosphoesterase
AA314_RS09040	COG1090	epimerase
AA314_RS09050	COG0142	geranyltranstransferase activity
AA314_RS09060	COG1562	ergosterol biosynthetic process
AA314_RS09070	COG1233	COG1233 Phytoene dehydrogenase and related
AA314_RS09130	COG0028	Belongs to the TPP enzyme family
AA314_RS09180	COG3425	synthase
AA314_RS09185	COG3361	conserved protein (COG2071)
AA314_RS09195	COG0515	serine threonine protein kinase
AA314_RS09200	COG4191	Histidine kinase
AA314_RS09240	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AA314_RS09250	COG0583	DNA-binding transcription factor activity
AA314_RS09255	COG0515	serine threonine protein kinase
AA314_RS09270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA314_RS09285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AA314_RS09290	COG3002	Belongs to the UPF0753 family
AA314_RS09295	COG0659	secondary active sulfate transmembrane transporter activity
AA314_RS09300	COG1595	DNA-templated transcription, initiation
AA314_RS09315	COG2204	response regulator
AA314_RS09345	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA314_RS09360	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AA314_RS09365	COG0363	glucosamine-6-phosphate deaminase activity
AA314_RS09370	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AA314_RS09380	COG0515	serine threonine protein kinase
AA314_RS09420	COG1668	transmembrane transport
AA314_RS09425	COG4555	ABC transporter
AA314_RS09485	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA314_RS09535	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS09545	COG0420	3'-5' exonuclease activity
AA314_RS09615	COG1335	isochorismatase
AA314_RS09620	COG1522	sequence-specific DNA binding
AA314_RS09645	COG1309	transcriptional regulator
AA314_RS09650	COG0596	Alpha beta hydrolase
AA314_RS09730	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AA314_RS09735	COG4181	ATPase activity
AA314_RS09750	COG2072	flavoprotein involved in K transport
AA314_RS09810	COG1846	Transcriptional regulator
AA314_RS09815	COG2085	NADP oxidoreductase coenzyme F420-dependent
AA314_RS09820	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS09830	COG2814	Major facilitator Superfamily
AA314_RS09835	COG0583	DNA-binding transcription factor activity
AA314_RS09850	COG0643	Histidine kinase
AA314_RS09850	COG2198	Histidine kinase
AA314_RS09860	COG0745	RESPONSE REGULATOR receiver
AA314_RS09865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA314_RS09900	COG1858	cytochrome C peroxidase
AA314_RS09980	COG1201	RNA secondary structure unwinding
AA314_RS10000	COG0395	ABC-type sugar transport system, permease component
AA314_RS10010	COG3842	ATPase activity
AA314_RS10020	COG1404	Belongs to the peptidase S8 family
AA314_RS10030	COG4251	negative regulation of phosphorylation
AA314_RS10035	COG0784	Response regulator, receiver
AA314_RS10040	COG2205	protein histidine kinase activity
AA314_RS10085	COG0601	transmembrane transport
AA314_RS10125	COG2322	membrane
AA314_RS10155	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AA314_RS10185	COG3706	GGDEF domain
AA314_RS10195	COG1360	Flagellar Motor Protein
AA314_RS10210	COG0419	ATPase involved in DNA repair
AA314_RS10250	COG0489	protein tyrosine kinase activity
AA314_RS10265	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AA314_RS10290	COG0438	transferase activity, transferring glycosyl groups
AA314_RS10330	COG0438	transferase activity, transferring glycosyl groups
AA314_RS10335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AA314_RS10360	COG2311	Membrane
AA314_RS10380	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_RS10380	COG2319	Wd-40 repeat
AA314_RS10395	COG0596	Alpha beta hydrolase
AA314_RS10400	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS10425	COG3724	N-succinylarginine dihydrolase activity
AA314_RS10430	COG1560	Kdo2-lipid A biosynthetic process
AA314_RS10445	COG1137	ATPase activity
AA314_RS10460	COG0438	transferase activity, transferring glycosyl groups
AA314_RS10465	COG2130	NADP-dependent
AA314_RS10475	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS10490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA314_RS10625	COG3942	CHAP domain
AA314_RS10625	COG1388	LysM domain
AA314_RS10635	COG0625	glutathione transferase activity
AA314_RS10660	COG0515	serine threonine protein kinase
AA314_RS10705	COG2304	oxidoreductase activity
AA314_RS10755	COG0515	serine threonine protein kinase
AA314_RS10780	COG2815	serine threonine protein kinase
AA314_RS10780	COG0515	serine threonine protein kinase
AA314_RS10785	COG0515	serine threonine protein kinase
AA314_RS10785	COG2815	serine threonine protein kinase
AA314_RS10795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA314_RS10795	COG5549	protein import
AA314_RS10860	COG5002	protein histidine kinase activity
AA314_RS10865	COG5002	protein histidine kinase activity
AA314_RS10875	COG1472	Belongs to the glycosyl hydrolase 3 family
AA314_RS10880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AA314_RS10880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AA314_RS10880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AA314_RS10885	COG1490	D-aminoacyl-tRNA deacylase activity
AA314_RS10930	COG0629	single-stranded DNA binding
AA314_RS10935	COG2009	succinate dehydrogenase
AA314_RS10940	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AA314_RS10945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AA314_RS10955	COG4191	Histidine kinase
AA314_RS10960	COG2204	response regulator
AA314_RS10965	COG0456	acetyltransferase
AA314_RS10970	COG1007	ATP synthesis coupled electron transport
AA314_RS10980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AA314_RS10985	COG0713	ATP synthesis coupled electron transport
AA314_RS10990	COG0839	Belongs to the complex I subunit 6 family
AA314_RS11010	COG2815	serine threonine protein kinase
AA314_RS11010	COG0515	serine threonine protein kinase
AA314_RS11015	COG3830	Belongs to the UPF0237 family
AA314_RS11015	COG0560	Phosphoserine phosphatase
AA314_RS11035	COG0071	Belongs to the small heat shock protein (HSP20) family
AA314_RS11045	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AA314_RS11050	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AA314_RS11055	COG0504	CTP synthase activity
AA314_RS11065	COG1132	(ABC) transporter
AA314_RS11070	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AA314_RS11085	COG0745	RESPONSE REGULATOR receiver
AA314_RS11110	COG0564	pseudouridine synthase activity
AA314_RS11160	COG0501	Belongs to the peptidase M48B family
AA314_RS11175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_RS11180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_RS11195	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AA314_RS11210	COG0484	heat shock protein binding
AA314_RS11260	COG0511	ligase activity, forming carbon-carbon bonds
AA314_RS11260	COG5016	pyruvate
AA314_RS11265	COG0439	Biotin carboxylase
AA314_RS11275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA314_RS11290	COG2267	carboxylic ester hydrolase activity
AA314_RS11295	COG0339	signal peptide processing
AA314_RS11325	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AA314_RS11330	COG2264	protein methyltransferase activity
AA314_RS11350	COG0515	serine threonine protein kinase
AA314_RS11375	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AA314_RS11385	COG2204	response regulator
AA314_RS11415	COG4191	Histidine kinase
AA314_RS11425	COG1714	RDD family
AA314_RS11435	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AA314_RS11465	COG2264	protein methyltransferase activity
AA314_RS11495	COG3344	reverse transcriptase
AA314_RS11500	COG0612	Peptidase, M16
AA314_RS11510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA314_RS11555	COG2124	cytochrome p450
AA314_RS11590	COG0300	oxidoreductase activity
AA314_RS11595	COG1959	2 iron, 2 sulfur cluster binding
AA314_RS11600	COG0719	Fe-S assembly protein
AA314_RS11605	COG0396	ATPase activity
AA314_RS11610	COG0719	Fe-S assembly protein
AA314_RS11620	COG0822	iron-sulfur transferase activity
AA314_RS11625	COG2151	metal-sulfur cluster biosynthetic enzyme
AA314_RS11640	COG1024	Enoyl-CoA hydratase
AA314_RS11665	COG0515	serine threonine protein kinase
AA314_RS11665	COG2815	serine threonine protein kinase
AA314_RS11670	COG0514	ATP-dependent DNA helicase (RecQ)
AA314_RS11685	COG1696	Membrane protein involved in D-alanine export
AA314_RS11695	COG1136	(ABC) transporter
AA314_RS11695	COG0577	efflux transmembrane transporter activity
AA314_RS11700	COG0577	efflux transmembrane transporter activity
AA314_RS11700	COG1136	(ABC) transporter
AA314_RS11715	COG0577	efflux transmembrane transporter activity
AA314_RS11715	COG1136	(ABC) transporter
AA314_RS11735	COG2204	response regulator
AA314_RS11740	COG2204	response regulator
AA314_RS11745	COG0432	Pfam Uncharacterised protein family UPF0047
AA314_RS11795	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AA314_RS11800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA314_RS11855	COG0515	serine threonine protein kinase
AA314_RS11880	COG0633	Ferredoxin
AA314_RS11890	COG2814	Major facilitator Superfamily
AA314_RS11910	COG2124	cytochrome p450
AA314_RS11930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA314_RS11955	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS11960	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_RS11965	COG2124	cytochrome p450
AA314_RS12055	COG4191	Histidine kinase
AA314_RS12100	COG0205	6-phosphofructokinase activity
AA314_RS12110	COG0625	glutathione transferase activity
AA314_RS12115	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AA314_RS12125	COG1690	Belongs to the RtcB family
AA314_RS12130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AA314_RS12165	COG2204	response regulator
AA314_RS12185	COG0667	Aldo Keto reductase
AA314_RS12205	COG4251	negative regulation of phosphorylation
AA314_RS12220	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AA314_RS12230	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AA314_RS12235	COG0156	8-amino-7-oxononanoate synthase activity
AA314_RS12240	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AA314_RS12250	COG0436	Aminotransferase
AA314_RS12260	COG0784	Response regulator, receiver
AA314_RS12265	COG1297	OPT oligopeptide transporter protein
AA314_RS12285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA314_RS12285	COG3321	synthase
AA314_RS12285	COG4221	oxidoreductase activity
AA314_RS12285	COG0300	oxidoreductase activity
AA314_RS12305	COG2165	general secretion pathway protein
AA314_RS12325	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AA314_RS12330	COG0471	metal ion transport
AA314_RS12330	COG3273	potassium ion transport
AA314_RS12355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA314_RS12375	COG0644	oxidoreductase
AA314_RS12390	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AA314_RS12420	COG3279	Response regulator of the LytR AlgR family
AA314_RS12455	COG1201	RNA secondary structure unwinding
AA314_RS12460	COG1793	dna ligase
AA314_RS12480	COG0564	pseudouridine synthase activity
AA314_RS12495	COG1940	carbohydrate kinase activity
AA314_RS12535	COG3275	phosphorelay sensor kinase activity
AA314_RS12555	COG0297	glycogen (starch) synthase activity
AA314_RS12560	COG0515	serine threonine protein kinase
AA314_RS12560	COG2815	serine threonine protein kinase
AA314_RS12615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA314_RS12615	COG4651	solute:proton antiporter activity
AA314_RS12710	COG2124	cytochrome p450
AA314_RS12735	COG5464	transposase or invertase
AA314_RS12785	COG0784	Response regulator, receiver
AA314_RS12785	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA314_RS12795	COG0402	S-adenosylhomocysteine deaminase activity
AA314_RS12845	COG1228	amidohydrolase
AA314_RS12875	COG0745	RESPONSE REGULATOR receiver
AA314_RS12880	COG5002	protein histidine kinase activity
AA314_RS12890	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AA314_RS12905	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AA314_RS12925	COG1716	ATPase activity
AA314_RS12930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA314_RS12940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA314_RS12955	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AA314_RS12965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AA314_RS12970	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AA314_RS12985	COG1741	Belongs to the pirin family
AA314_RS12990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA314_RS13040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA314_RS13055	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS13065	COG2755	lipolytic protein G-D-S-L family
AA314_RS13065	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AA314_RS13075	COG2304	oxidoreductase activity
AA314_RS13085	COG3119	arylsulfatase activity
AA314_RS13090	COG3119	arylsulfatase activity
AA314_RS13095	COG0123	including yeast histone deacetylase and acetoin utilization protein
AA314_RS13115	COG2267	carboxylic ester hydrolase activity
AA314_RS13135	COG1131	(ABC) transporter
AA314_RS13165	COG0405	Gamma-glutamyltransferase
AA314_RS13170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AA314_RS13175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AA314_RS13180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AA314_RS13190	COG0515	serine threonine protein kinase
AA314_RS13275	COG2723	6-phospho-beta-galactosidase activity
AA314_RS13280	COG4608	Belongs to the ABC transporter superfamily
AA314_RS13285	COG0444	Belongs to the ABC transporter superfamily
AA314_RS13290	COG0601	transmembrane transport
AA314_RS13320	COG2124	cytochrome p450
AA314_RS13330	COG0183	Belongs to the thiolase family
AA314_RS13355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA314_RS13360	COG4948	Mandelate Racemase Muconate Lactonizing
AA314_RS13385	COG0438	transferase activity, transferring glycosyl groups
AA314_RS13390	COG0438	transferase activity, transferring glycosyl groups
AA314_RS13400	COG1115	amino acid carrier protein
AA314_RS13425	COG2183	response to ionizing radiation
AA314_RS13450	COG0667	Aldo Keto reductase
AA314_RS13465	COG0326	Molecular chaperone. Has ATPase activity
AA314_RS13470	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA314_RS13500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AA314_RS13505	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AA314_RS13510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA314_RS13510	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA314_RS13545	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AA314_RS13550	COG5002	protein histidine kinase activity
AA314_RS13580	COG0515	serine threonine protein kinase
AA314_RS13595	COG0248	Ppx GppA phosphatase
AA314_RS13600	COG2272	Belongs to the type-B carboxylesterase lipase family
AA314_RS13660	COG0515	serine threonine protein kinase
AA314_RS13670	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA314_RS13670	COG0784	Response regulator, receiver
AA314_RS13675	COG3321	synthase
AA314_RS13675	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS13675	COG0604	alcohol dehydrogenase
AA314_RS13700	COG1960	acyl-CoA dehydrogenase activity
AA314_RS13710	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AA314_RS13715	COG2205	protein histidine kinase activity
AA314_RS13780	COG0513	Belongs to the DEAD box helicase family
AA314_RS13795	COG1819	glycosyl
AA314_RS13830	COG0515	serine threonine protein kinase
AA314_RS13860	COG0564	pseudouridine synthase activity
AA314_RS13910	COG4191	Histidine kinase
AA314_RS13925	COG1215	transferase activity, transferring glycosyl groups
AA314_RS13945	COG0495	leucyl-tRNA aminoacylation
AA314_RS13950	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA314_RS13970	COG0398	Pfam SNARE associated Golgi protein
AA314_RS13985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AA314_RS13990	COG0484	heat shock protein binding
AA314_RS14000	COG0242	peptide deformylase activity
AA314_RS14005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AA314_RS14010	COG0739	heme binding
AA314_RS14015	COG0776	regulation of translation
AA314_RS14030	COG1183	phosphatidylcholine synthase activity
AA314_RS14035	COG1058	Belongs to the CinA family
AA314_RS14035	COG1546	Belongs to the CinA family
AA314_RS14055	COG0204	Acyl-transferase
AA314_RS14060	COG1252	NADH dehydrogenase
AA314_RS14085	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AA314_RS14150	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AA314_RS14155	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AA314_RS14155	COG0116	Belongs to the methyltransferase superfamily
AA314_RS14180	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA314_RS14185	COG0154	amidase activity
AA314_RS14190	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA314_RS14195	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA314_RS14230	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AA314_RS14235	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AA314_RS14240	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AA314_RS14245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AA314_RS14260	COG0515	serine threonine protein kinase
AA314_RS14260	COG0457	Tetratricopeptide repeat
AA314_RS14275	COG4221	oxidoreductase activity
AA314_RS14280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA314_RS14290	COG1666	GTP binding
AA314_RS14295	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AA314_RS14315	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS14350	COG3850	Histidine kinase
AA314_RS14350	COG5002	protein histidine kinase activity
AA314_RS14395	COG4257	antibiotic catabolic process
AA314_RS14410	COG1072	(Pantothenic acid kinase))
AA314_RS14415	COG1090	epimerase
AA314_RS14460	COG5002	protein histidine kinase activity
AA314_RS14465	COG0204	Acyl-transferase
AA314_RS14465	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_RS14485	COG2755	lipolytic protein G-D-S-L family
AA314_RS14485	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AA314_RS14650	COG4251	negative regulation of phosphorylation
AA314_RS14660	COG5002	protein histidine kinase activity
AA314_RS14685	COG0848	biopolymer transport protein
AA314_RS14705	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AA314_RS14715	COG2205	protein histidine kinase activity
AA314_RS14715	COG0784	Response regulator, receiver
AA314_RS14740	COG0702	epimerase
AA314_RS14785	COG0625	glutathione transferase activity
AA314_RS14805	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AA314_RS14825	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AA314_RS14835	COG2205	protein histidine kinase activity
AA314_RS14840	COG2205	protein histidine kinase activity
AA314_RS14855	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AA314_RS14865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA314_RS14870	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_RS14915	COG2967	ApaG domain
AA314_RS14920	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AA314_RS14940	COG2815	serine threonine protein kinase
AA314_RS14940	COG0515	serine threonine protein kinase
AA314_RS14945	COG0009	L-threonylcarbamoyladenylate synthase
AA314_RS14990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA314_RS14990	COG0723	plastoquinol--plastocyanin reductase activity
AA314_RS15005	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AA314_RS15015	COG1205	dead DEAH box helicase
AA314_RS15015	COG1111	helicase
AA314_RS15020	COG3359	exonuclease
AA314_RS15025	COG2010	Cytochrome c
AA314_RS15035	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AA314_RS15045	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AA314_RS15065	COG3243	poly(R)-hydroxyalkanoic acid synthase
AA314_RS15085	COG0546	phosphoglycolate phosphatase activity
AA314_RS15095	COG2814	Major facilitator Superfamily
AA314_RS15105	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AA314_RS15125	COG2259	Doxx family
AA314_RS15130	COG3590	peptidase
AA314_RS15135	COG1505	serine-type exopeptidase activity
AA314_RS15145	COG0783	Belongs to the Dps family
AA314_RS15150	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AA314_RS15155	COG0450	alkyl hydroperoxide reductase
AA314_RS15160	COG3604	Transcriptional regulator
AA314_RS15175	COG0739	heme binding
AA314_RS15175	COG1196	nuclear chromosome segregation
AA314_RS15175	COG0741	lytic transglycosylase activity
AA314_RS15215	COG3854	ATPases associated with a variety of cellular activities
AA314_RS15245	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_RS15355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA314_RS15375	COG1187	pseudouridine synthase activity
AA314_RS15385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA314_RS15390	COG3545	Serine hydrolase
AA314_RS15410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AA314_RS15430	COG2813	Specifically methylates the guanine in position
AA314_RS15500	COG0534	Mate efflux family protein
AA314_RS15510	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA314_RS15555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA314_RS15555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA314_RS15560	COG1619	proteins homologs of microcin C7 resistance protein MccF
AA314_RS15565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA314_RS15570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AA314_RS15575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA314_RS15600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_RS15645	COG1100	Small GTP-binding protein
AA314_RS15665	COG0515	serine threonine protein kinase
AA314_RS15670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AA314_RS15675	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AA314_RS15685	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AA314_RS15705	COG0590	tRNA wobble adenosine to inosine editing
AA314_RS15725	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AA314_RS15740	COG0463	Glycosyl transferase, family 2
AA314_RS15750	COG0515	serine threonine protein kinase
AA314_RS15750	COG2815	serine threonine protein kinase
AA314_RS15760	COG0204	Acyl-transferase
AA314_RS15800	COG5002	protein histidine kinase activity
AA314_RS15805	COG0156	8-amino-7-oxononanoate synthase activity
AA314_RS15835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AA314_RS15850	COG0514	ATP-dependent DNA helicase (RecQ)
AA314_RS15860	COG2003	Belongs to the UPF0758 family
AA314_RS15880	COG0745	RESPONSE REGULATOR receiver
AA314_RS15885	COG5002	protein histidine kinase activity
AA314_RS15895	COG0492	ferredoxin-NADP+ reductase activity
AA314_RS15905	COG0315	cyclic pyranopterin monophosphate synthase activity
AA314_RS15920	COG1819	glycosyl
AA314_RS15935	COG1999	signal sequence binding
AA314_RS15955	COG1309	transcriptional regulator
AA314_RS15975	COG3425	synthase
AA314_RS16140	COG1832	CoA-binding protein
AA314_RS16150	COG2226	methyltransferase
AA314_RS16155	COG0646	methionine synthase
AA314_RS16155	COG1410	methionine synthase
AA314_RS16165	COG1657	PFAM Prenyltransferase squalene oxidase
AA314_RS16170	COG2124	cytochrome p450
AA314_RS16245	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS16260	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AA314_RS16265	COG0084	hydrolase, TatD family'
AA314_RS16290	COG4970	Tfp pilus assembly protein FimT
AA314_RS16335	COG0210	DNA helicase
AA314_RS16340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AA314_RS16360	COG2137	regulation of response to DNA damage stimulus
AA314_RS16365	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA314_RS16385	COG0860	N-Acetylmuramoyl-L-alanine amidase
AA314_RS16390	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AA314_RS16395	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AA314_RS16435	COG0544	peptidyl-prolyl cis-trans isomerase activity
AA314_RS16440	COG0740	serine-type endopeptidase activity
AA314_RS16450	COG1505	serine-type exopeptidase activity
AA314_RS16460	COG4166	transmembrane transport
AA314_RS16475	COG4565	transcriptional regulatory protein
AA314_RS16480	COG1678	Uncharacterized ACR, COG1678
AA314_RS16485	COG0271	Belongs to the BolA IbaG family
AA314_RS16490	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AA314_RS16510	COG0006	proline dipeptidase activity
AA314_RS16565	COG3148	PFAM DTW domain containing protein
AA314_RS16620	COG0437	4 iron, 4 sulfur cluster binding
AA314_RS16660	COG0515	serine threonine protein kinase
AA314_RS16670	COG2815	serine threonine protein kinase
AA314_RS16670	COG0515	serine threonine protein kinase
AA314_RS16705	COG3278	Belongs to the heme-copper respiratory oxidase family
AA314_RS16750	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_RS16750	COG2319	Wd-40 repeat
AA314_RS16795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA314_RS16815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA314_RS16835	COG2304	oxidoreductase activity
AA314_RS16905	COG0515	serine threonine protein kinase
AA314_RS16905	COG2815	serine threonine protein kinase
AA314_RS16910	COG0531	amino acid
AA314_RS16945	COG2204	response regulator
AA314_RS16960	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA314_RS16970	COG0515	serine threonine protein kinase
AA314_RS16970	COG2815	serine threonine protein kinase
AA314_RS16975	COG0515	serine threonine protein kinase
AA314_RS16975	COG2815	serine threonine protein kinase
AA314_RS16990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AA314_RS17030	COG0625	glutathione transferase activity
AA314_RS17035	COG0583	DNA-binding transcription factor activity
AA314_RS17090	COG4974	Belongs to the 'phage' integrase family
AA314_RS17105	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AA314_RS17120	COG0183	Belongs to the thiolase family
AA314_RS17125	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA314_RS17125	COG1024	Enoyl-CoA hydratase
AA314_RS17145	COG3394	polysaccharide catabolic process
AA314_RS17150	COG0463	Glycosyl transferase, family 2
AA314_RS17155	COG3706	GGDEF domain
AA314_RS17170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AA314_RS17175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AA314_RS17185	COG0737	Belongs to the 5'-nucleotidase family
AA314_RS17195	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AA314_RS17200	COG2223	nitrite transmembrane transporter activity
AA314_RS17210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AA314_RS17220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA314_RS17225	COG0497	DNA recombination
AA314_RS17230	COG0631	protein serine/threonine phosphatase activity
AA314_RS17235	COG0739	heme binding
AA314_RS17245	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AA314_RS17250	COG0653	protein targeting
AA314_RS17255	COG0052	Belongs to the universal ribosomal protein uS2 family
AA314_RS17260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AA314_RS17265	COG0528	UMP kinase activity
AA314_RS17270	COG0233	cytoplasmic translational termination
AA314_RS17280	COG1965	Belongs to the frataxin family
AA314_RS17295	COG0543	2 iron, 2 sulfur cluster binding
AA314_RS17295	COG0493	'glutamate synthase
AA314_RS17310	COG0463	Glycosyl transferase, family 2
AA314_RS17405	COG0443	Heat shock 70 kDa protein
AA314_RS17410	COG0443	Heat shock 70 kDa protein
AA314_RS17430	COG0109	protoheme IX farnesyltransferase activity
AA314_RS17450	COG2205	protein histidine kinase activity
AA314_RS17455	COG0745	RESPONSE REGULATOR receiver
AA314_RS17470	COG1278	Cold shock
AA314_RS17530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AA314_RS17530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AA314_RS17540	COG0585	pseudouridine synthase activity
AA314_RS17560	COG3047	cAMP biosynthetic process
AA314_RS17560	COG2885	chlorophyll binding
AA314_RS17600	COG2084	Dehydrogenase
AA314_RS17635	COG0513	Belongs to the DEAD box helicase family
AA314_RS17680	COG0708	Exodeoxyribonuclease III
AA314_RS17735	COG0517	IMP dehydrogenase activity
AA314_RS17735	COG0516	GMP reductase activity
AA314_RS17740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA314_RS17745	COG2204	response regulator
AA314_RS17765	COG2885	chlorophyll binding
AA314_RS17795	COG2201	protein-glutamate methylesterase activity
AA314_RS17815	COG0254	rRNA binding
AA314_RS17835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA314_RS17840	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AA314_RS17845	COG1690	Belongs to the RtcB family
AA314_RS17860	COG4191	Histidine kinase
AA314_RS17860	COG0784	Response regulator, receiver
AA314_RS17895	COG0513	Belongs to the DEAD box helicase family
AA314_RS17935	COG0513	Belongs to the DEAD box helicase family
AA314_RS17985	COG1024	Enoyl-CoA hydratase
AA314_RS17985	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA314_RS17990	COG0183	Belongs to the thiolase family
AA314_RS18025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_RS18030	COG2204	response regulator
AA314_RS18035	COG0642	Histidine kinase
AA314_RS18095	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AA314_RS18105	COG0300	oxidoreductase activity
AA314_RS18130	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS18175	COG0300	oxidoreductase activity
AA314_RS18180	COG0515	serine threonine protein kinase
AA314_RS18230	COG2815	serine threonine protein kinase
AA314_RS18230	COG0515	serine threonine protein kinase
AA314_RS18255	COG0517	IMP dehydrogenase activity
AA314_RS18255	COG1994	Peptidase M50
AA314_RS18260	COG2815	serine threonine protein kinase
AA314_RS18260	COG0515	serine threonine protein kinase
AA314_RS18265	COG1396	sequence-specific DNA binding
AA314_RS18275	COG3507	Belongs to the glycosyl hydrolase 43 family
AA314_RS18325	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AA314_RS18395	COG0515	serine threonine protein kinase
AA314_RS18395	COG2815	serine threonine protein kinase
AA314_RS18415	COG4771	TonB-dependent receptor
AA314_RS18420	COG0542	response to heat
AA314_RS18445	COG0352	thiamine-phosphate diphosphorylase activity
AA314_RS18450	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AA314_RS18455	COG0351	phosphomethylpyrimidine kinase
AA314_RS18470	COG0359	binds to the 23S rRNA
AA314_RS18475	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AA314_RS18480	COG0360	Binds together with S18 to 16S ribosomal RNA
AA314_RS18485	COG0193	aminoacyl-tRNA hydrolase activity
AA314_RS18490	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AA314_RS18495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AA314_RS18500	COG2088	sporulation resulting in formation of a cellular spore
AA314_RS18515	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AA314_RS18525	COG2274	protein secretion by the type I secretion system
AA314_RS18530	COG0189	ligase activity
AA314_RS18530	COG4067	protein conserved in archaea
AA314_RS18570	COG0745	RESPONSE REGULATOR receiver
AA314_RS18580	COG0784	Response regulator, receiver
AA314_RS18585	COG4251	negative regulation of phosphorylation
AA314_RS18605	COG2226	methyltransferase
AA314_RS18610	COG0300	oxidoreductase activity
AA314_RS18620	COG1773	rubredoxin
AA314_RS18635	COG0612	Peptidase, M16
AA314_RS18640	COG4191	Histidine kinase
AA314_RS18670	COG1304	FMN binding
AA314_RS18705	COG5002	protein histidine kinase activity
AA314_RS18730	COG0633	Ferredoxin
AA314_RS18740	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AA314_RS18745	COG0316	Belongs to the HesB IscA family
AA314_RS18750	COG0822	iron-sulfur transferase activity
AA314_RS18755	COG1104	cysteine desulfurase activity
AA314_RS18795	COG2030	dehydratase
AA314_RS18805	COG2814	Major facilitator Superfamily
AA314_RS18825	COG0457	Tetratricopeptide repeat
AA314_RS18825	COG0515	serine threonine protein kinase
AA314_RS18855	COG0697	spore germination
AA314_RS18865	COG0534	Mate efflux family protein
AA314_RS18875	COG3220	belongs to the UPF0276 family
AA314_RS18965	COG4650	regulator
AA314_RS18970	COG1690	Belongs to the RtcB family
AA314_RS18975	COG0430	RNA-3'-phosphate cyclase activity
AA314_RS18985	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA314_RS19010	COG0835	chemotaxis
AA314_RS19010	COG0784	Response regulator, receiver
AA314_RS19015	COG0217	transcriptional regulatory protein
AA314_RS19020	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AA314_RS19025	COG0632	four-way junction helicase activity
AA314_RS19110	COG1063	alcohol dehydrogenase
AA314_RS19115	COG2255	four-way junction helicase activity
AA314_RS19125	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AA314_RS19130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AA314_RS19130	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AA314_RS19150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AA314_RS19160	COG0730	response to heat
AA314_RS19190	COG3220	belongs to the UPF0276 family
AA314_RS19225	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AA314_RS19245	COG2989	Protein conserved in bacteria
AA314_RS19275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AA314_RS19280	COG2890	protein-(glutamine-N5) methyltransferase activity
AA314_RS19285	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AA314_RS19295	COG1253	flavin adenine dinucleotide binding
AA314_RS19305	COG1196	nuclear chromosome segregation
AA314_RS19330	COG3829	transcription factor binding
AA314_RS19345	COG0459	protein refolding
AA314_RS19350	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AA314_RS19370	COG1758	RNA polymerase activity
AA314_RS19380	COG0683	leucine binding
AA314_RS19385	COG0477	Major facilitator Superfamily
AA314_RS19410	COG1595	DNA-templated transcription, initiation
AA314_RS19435	COG2124	cytochrome p450
AA314_RS19440	COG4585	Histidine kinase
AA314_RS19445	COG2197	response regulator
AA314_RS19455	COG1335	isochorismatase
AA314_RS19460	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AA314_RS19465	COG2814	Major facilitator Superfamily
AA314_RS19495	COG1268	BioY protein
AA314_RS19500	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_RS19505	COG2205	protein histidine kinase activity
AA314_RS19505	COG0784	Response regulator, receiver
AA314_RS19510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA314_RS19545	COG0583	DNA-binding transcription factor activity
AA314_RS19565	COG0412	Dienelactone hydrolase
AA314_RS19710	COG1129	ABC transporter
AA314_RS19710	COG0842	Transport permease protein
AA314_RS19805	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AA314_RS19815	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA314_RS19820	COG0737	Belongs to the 5'-nucleotidase family
AA314_RS19830	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA314_RS19835	COG1132	(ABC) transporter
AA314_RS19960	COG1136	(ABC) transporter
AA314_RS19965	COG0577	efflux transmembrane transporter activity
AA314_RS19965	COG1136	(ABC) transporter
AA314_RS19995	COG1253	flavin adenine dinucleotide binding
AA314_RS20000	COG5002	protein histidine kinase activity
AA314_RS20000	COG2205	protein histidine kinase activity
AA314_RS20000	COG0784	Response regulator, receiver
AA314_RS20005	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AA314_RS20015	COG0704	Plays a role in the regulation of phosphate uptake
AA314_RS20020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AA314_RS20025	COG0581	inorganic phosphate transmembrane transporter activity
AA314_RS20030	COG0573	inorganic phosphate transmembrane transporter activity
AA314_RS20035	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AA314_RS20045	COG2062	phosphohistidine phosphatase, SixA
AA314_RS20055	COG5002	protein histidine kinase activity
AA314_RS20060	COG0745	RESPONSE REGULATOR receiver
AA314_RS20075	COG1399	metal-binding, possibly nucleic acid-binding protein
AA314_RS20130	COG3158	transport of potassium into the cell
AA314_RS20135	COG2066	Belongs to the glutaminase family
AA314_RS20145	COG0667	Aldo Keto reductase
AA314_RS20150	COG1595	DNA-templated transcription, initiation
AA314_RS20155	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AA314_RS20190	COG0739	heme binding
AA314_RS20190	COG1196	nuclear chromosome segregation
AA314_RS20190	COG0741	lytic transglycosylase activity
AA314_RS20215	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AA314_RS20230	COG0583	DNA-binding transcription factor activity
AA314_RS20235	COG4974	Belongs to the 'phage' integrase family
AA314_RS20260	COG0028	Belongs to the TPP enzyme family
AA314_RS20270	COG0668	transmembrane transport
AA314_RS20275	COG3387	PFAM Glycoside hydrolase 15-related
AA314_RS20285	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AA314_RS20290	COG0416	fatty acid biosynthetic process
AA314_RS20295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA314_RS20305	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS20310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA314_RS20315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA314_RS20320	COG0698	ribose 5-phosphate isomerase
AA314_RS20325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AA314_RS20330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AA314_RS20335	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA314_RS20335	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA314_RS20340	COG1657	PFAM Prenyltransferase squalene oxidase
AA314_RS20385	COG2124	cytochrome p450
AA314_RS20395	COG2124	cytochrome p450
AA314_RS20405	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA314_RS20405	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA314_RS20410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AA314_RS20415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA314_RS20425	COG0745	RESPONSE REGULATOR receiver
AA314_RS20430	COG0784	Response regulator, receiver
AA314_RS20430	COG0643	Histidine kinase
AA314_RS20430	COG2198	Histidine kinase
AA314_RS20430	COG0643	Histidine kinase
AA314_RS20430	COG0784	Response regulator, receiver
AA314_RS20430	COG2198	Histidine kinase
AA314_RS20435	COG0835	chemotaxis
AA314_RS20450	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AA314_RS20455	COG2201	protein-glutamate methylesterase activity
AA314_RS20465	COG5280	Phage tail tape measure protein TP901
AA314_RS20465	COG3953	SLT domain
AA314_RS20480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AA314_RS20520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AA314_RS20525	COG0745	RESPONSE REGULATOR receiver
AA314_RS20530	COG0495	leucyl-tRNA aminoacylation
AA314_RS20550	COG3956	TIGRFAM MazG family protein
AA314_RS20560	COG0457	Tetratricopeptide repeat
AA314_RS20570	COG1480	7TM receptor with intracellular HD hydrolase
AA314_RS20575	COG0662	Cupin 2, conserved barrel domain protein
AA314_RS20575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AA314_RS20610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AA314_RS20615	COG4591	ABC-type transport system involved in lipoprotein release permease component
AA314_RS20620	COG1136	(ABC) transporter
AA314_RS20625	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA314_RS20635	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA314_RS20640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AA314_RS20645	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA314_RS20665	COG2095	MarC family integral membrane protein
AA314_RS20675	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA314_RS20695	COG1247	-acetyltransferase
AA314_RS20705	COG2985	domain, Protein
AA314_RS20705	COG0569	domain protein
AA314_RS20720	COG1132	(ABC) transporter
AA314_RS20730	COG3227	Zinc metalloprotease (Elastase)
AA314_RS20735	COG1519	Transferase
AA314_RS20745	COG1663	tetraacyldisaccharide 4'-kinase activity
AA314_RS20750	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AA314_RS20750	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AA314_RS20755	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AA314_RS20755	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AA314_RS20765	COG1561	YicC-like family, N-terminal region
AA314_RS20770	COG0194	GDP metabolic process
AA314_RS20810	COG1509	lysine 2,3-aminomutase activity
AA314_RS20840	COG0343	queuine tRNA-ribosyltransferase activity
AA314_RS20845	COG1862	Preprotein translocase
AA314_RS20850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AA314_RS20855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AA314_RS20865	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AA314_RS20865	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AA314_RS20895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AA314_RS20900	COG1597	lipid kinase activity
AA314_RS20910	COG2204	response regulator
AA314_RS20915	COG2205	protein histidine kinase activity
AA314_RS20920	COG0659	secondary active sulfate transmembrane transporter activity
AA314_RS20925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA314_RS20930	COG0402	S-adenosylhomocysteine deaminase activity
AA314_RS20980	COG1193	negative regulation of DNA recombination
AA314_RS20990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA314_RS21000	COG0714	Associated with various cellular activities
AA314_RS21010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AA314_RS21025	COG2030	dehydratase
AA314_RS21035	COG1960	acyl-CoA dehydrogenase activity
AA314_RS21040	COG0077	Prephenate dehydratase
AA314_RS21040	COG1605	Chorismate mutase
AA314_RS21065	COG0811	peptide transport
AA314_RS21085	COG0444	Belongs to the ABC transporter superfamily
AA314_RS21090	COG4608	Belongs to the ABC transporter superfamily
AA314_RS21170	COG1716	ATPase activity
AA314_RS21190	COG0745	RESPONSE REGULATOR receiver
AA314_RS21195	COG0142	geranyltranstransferase activity
AA314_RS21200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AA314_RS21205	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AA314_RS21280	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AA314_RS21300	COG0741	lytic transglycosylase activity
AA314_RS21395	COG1295	ribonuclease BN
AA314_RS21400	COG0488	(ABC) transporter
AA314_RS21425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_RS21435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA314_RS21440	COG0343	queuine tRNA-ribosyltransferase activity
AA314_RS21475	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AA314_RS21480	COG2814	Major facilitator Superfamily
AA314_RS21500	COG0022	dehydrogenase e1 component
AA314_RS21510	COG0038	chloride channel
AA314_RS21515	COG5002	protein histidine kinase activity
AA314_RS21520	COG2208	phosphoserine phosphatase activity
AA314_RS21535	COG4771	TonB-dependent receptor
AA314_RS21545	COG0515	serine threonine protein kinase
AA314_RS21565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA314_RS21565	COG2022	thiamine diphosphate biosynthetic process
AA314_RS21590	COG2124	cytochrome p450
AA314_RS21600	COG4245	von Willebrand factor, type A
AA314_RS21605	COG0631	protein serine/threonine phosphatase activity
AA314_RS21610	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
AA314_RS21655	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS21660	COG1169	isochorismate synthase
AA314_RS21665	COG1021	2,3-dihydroxybenzoate-AMP ligase
AA314_RS21670	COG1535	isochorismatase
AA314_RS21670	COG3433	isochorismatase activity
AA314_RS21680	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AA314_RS21730	COG3596	GTP binding
AA314_RS21760	COG4104	PAAR repeat-containing protein
AA314_RS21760	COG3209	COG3209 Rhs family protein
AA314_RS21760	COG3209	COG3209 Rhs family protein
AA314_RS21760	COG4104	PAAR repeat-containing protein
AA314_RS21800	COG0459	protein refolding
AA314_RS21815	COG3706	GGDEF domain
AA314_RS21830	COG0525	valine-tRNA ligase activity
AA314_RS21845	COG0824	Thioesterase
AA314_RS21850	COG1494	fructose-1,6-bisphosphatase
AA314_RS21870	COG0148	phosphopyruvate hydratase activity
AA314_RS21875	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AA314_RS21885	COG2723	6-phospho-beta-galactosidase activity
AA314_RS21910	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AA314_RS21915	COG5002	protein histidine kinase activity
AA314_RS21965	COG1215	transferase activity, transferring glycosyl groups
AA314_RS21975	COG0515	serine threonine protein kinase
AA314_RS21990	COG0010	Belongs to the arginase family
AA314_RS22000	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AA314_RS22005	COG2814	Major facilitator Superfamily
AA314_RS22010	COG1984	allophanate hydrolase subunit 2
AA314_RS22015	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AA314_RS22020	COG4336	lyase activity
AA314_RS22030	COG0583	DNA-binding transcription factor activity
AA314_RS22045	COG2815	serine threonine protein kinase
AA314_RS22045	COG0515	serine threonine protein kinase
AA314_RS22050	COG1643	Atp-dependent helicase
AA314_RS22065	COG2124	cytochrome p450
AA314_RS22070	COG3321	synthase
AA314_RS22070	COG0604	alcohol dehydrogenase
AA314_RS22080	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AA314_RS22085	COG4464	protein tyrosine phosphatase activity
AA314_RS22225	COG2204	response regulator
AA314_RS22245	COG0529	Catalyzes the synthesis of activated sulfate
AA314_RS22270	COG0631	protein serine/threonine phosphatase activity
AA314_RS22285	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AA314_RS22290	COG1573	uracil-dna glycosylase
AA314_RS22300	COG0604	alcohol dehydrogenase
AA314_RS22305	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AA314_RS22315	COG5012	cobalamin binding
AA314_RS22320	COG1607	acyl-coa hydrolase
AA314_RS22325	COG3246	L-lysine catabolic process to acetate
AA314_RS22335	COG0183	Belongs to the thiolase family
AA314_RS22340	COG1309	transcriptional regulator
AA314_RS22345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA314_RS22395	COG0697	spore germination
AA314_RS22400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA314_RS22425	COG1819	glycosyl
AA314_RS22460	COG0784	Response regulator, receiver
AA314_RS22460	COG4191	Histidine kinase
AA314_RS22465	COG4251	negative regulation of phosphorylation
AA314_RS22480	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AA314_RS22570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA314_RS22635	COG0037	tRNA processing
AA314_RS22640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA314_RS22645	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AA314_RS22650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA314_RS22655	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AA314_RS22660	COG0736	holo-[acyl-carrier-protein] synthase activity
AA314_RS22665	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AA314_RS22665	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AA314_RS22670	COG0802	atpase or kinase
AA314_RS22690	COG4191	Histidine kinase
AA314_RS22705	COG1228	amidohydrolase
AA314_RS22710	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AA314_RS22725	COG3321	synthase
AA314_RS22725	COG0604	alcohol dehydrogenase
AA314_RS22735	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AA314_RS22770	COG1138	Cytochrome C-type biogenesis protein
AA314_RS22775	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AA314_RS22780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AA314_RS22790	COG4133	protoheme IX ABC transporter activity
AA314_RS22815	COG0438	transferase activity, transferring glycosyl groups
AA314_RS22890	COG0352	thiamine-phosphate diphosphorylase activity
AA314_RS22895	COG2022	thiamine diphosphate biosynthetic process
AA314_RS22915	COG3550	peptidyl-serine autophosphorylation
AA314_RS22970	COG0328	RNA-DNA hybrid ribonuclease activity
AA314_RS22990	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AA314_RS22995	COG0745	RESPONSE REGULATOR receiver
AA314_RS23005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA314_RS23010	COG0598	Magnesium transport protein CorA
AA314_RS23120	COG2937	Belongs to the GPAT DAPAT family
AA314_RS23125	COG0018	arginyl-trna synthetase
AA314_RS23130	COG2205	protein histidine kinase activity
AA314_RS23130	COG2202	Pas domain
AA314_RS23155	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AA314_RS23160	COG0049	tRNA binding
AA314_RS23165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AA314_RS23170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AA314_RS23175	COG0051	transcription antitermination factor activity, RNA binding
AA314_RS23180	COG0088	Forms part of the polypeptide exit tunnel
AA314_RS23185	COG0089	rRNA binding
AA314_RS23190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AA314_RS23195	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AA314_RS23200	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AA314_RS23205	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AA314_RS23210	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AA314_RS23215	COG0255	Belongs to the universal ribosomal protein uL29 family
AA314_RS23220	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AA314_RS23225	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AA314_RS23230	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AA314_RS23240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AA314_RS23245	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AA314_RS23250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AA314_RS23255	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AA314_RS23260	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AA314_RS23265	COG1841	ribosomal large subunit assembly
AA314_RS23270	COG0200	Binds to the 23S rRNA
AA314_RS23280	COG0563	adenylate kinase activity
AA314_RS23290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AA314_RS23295	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AA314_RS23300	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AA314_RS23305	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AA314_RS23310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AA314_RS23315	COG0202	RNA polymerase activity
AA314_RS23320	COG0203	ribosomal protein L17
AA314_RS23365	COG2313	pseudouridylate synthase activity
AA314_RS23400	COG0741	lytic transglycosylase activity
AA314_RS23425	COG3706	GGDEF domain
AA314_RS23440	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AA314_RS23475	COG3781	membrane
AA314_RS23485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AA314_RS23490	COG4266	Belongs to the allantoicase family
AA314_RS23495	COG2351	hydroxyisourate hydrolase activity
AA314_RS23500	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AA314_RS23510	COG0829	nickel cation binding
AA314_RS23515	COG0832	Belongs to the urease beta subunit family
AA314_RS23515	COG0831	urea catabolic process
AA314_RS23520	COG0804	urea catabolic process
AA314_RS23530	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AA314_RS23535	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AA314_RS23540	COG3250	beta-galactosidase activity
AA314_RS23615	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AA314_RS23625	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AA314_RS23645	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AA314_RS23650	COG1058	Belongs to the CinA family
AA314_RS23650	COG1546	Belongs to the CinA family
AA314_RS23655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_RS23660	COG0531	amino acid
AA314_RS23665	COG0017	Asparaginyl-tRNA synthetase
AA314_RS23685	COG1999	signal sequence binding
AA314_RS23690	COG2205	protein histidine kinase activity
AA314_RS23845	COG1100	Small GTP-binding protein
AA314_RS23860	COG2133	pyrroloquinoline quinone binding
AA314_RS23870	COG0641	radical SAM
AA314_RS23925	COG0515	serine threonine protein kinase
AA314_RS23925	COG2815	serine threonine protein kinase
AA314_RS23935	COG5464	transposase or invertase
AA314_RS23995	COG0217	transcriptional regulatory protein
AA314_RS24010	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AA314_RS24020	COG1136	(ABC) transporter
AA314_RS24020	COG0577	efflux transmembrane transporter activity
AA314_RS24050	COG3179	chitinase
AA314_RS24085	COG1819	glycosyl
AA314_RS24100	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA314_RS24125	COG3852	Histidine kinase
AA314_RS24145	COG2986	histidine ammonia-lyase
AA314_RS24150	COG0527	aspartate kinase activity
AA314_RS24190	COG1902	pentaerythritol trinitrate reductase activity
AA314_RS24210	COG0210	DNA helicase
AA314_RS24215	COG0443	Heat shock 70 kDa protein
AA314_RS24245	COG0501	Belongs to the peptidase M48B family
AA314_RS24255	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA314_RS24255	COG2146	nitrite reductase [NAD(P)H] activity
AA314_RS24275	COG1215	transferase activity, transferring glycosyl groups
AA314_RS24290	COG3420	alginic acid biosynthetic process
AA314_RS24295	COG1215	transferase activity, transferring glycosyl groups
AA314_RS24340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AA314_RS24360	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AA314_RS24380	COG1132	(ABC) transporter
AA314_RS24395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA314_RS24405	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS24415	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS24435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AA314_RS24435	COG0512	Glutamine amidotransferase of anthranilate synthase
AA314_RS24460	COG0025	NhaP-type Na H and K H
AA314_RS24465	COG0617	tRNA 3'-terminal CCA addition
AA314_RS24470	COG0482	sulfurtransferase activity
AA314_RS24505	COG0481	GTPase activity
AA314_RS24520	COG0540	Belongs to the ATCase OTCase family
AA314_RS24530	COG0505	Belongs to the CarA family
AA314_RS24555	COG1022	Amp-dependent synthetase and ligase
AA314_RS24560	COG0372	Belongs to the citrate synthase family
AA314_RS24565	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AA314_RS24575	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AA314_RS24585	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AA314_RS24585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AA314_RS24590	COG2226	methyltransferase
AA314_RS24595	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AA314_RS24595	COG1605	Chorismate mutase
AA314_RS24605	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AA314_RS24615	COG1575	Belongs to the MenA family. Type 1 subfamily
AA314_RS24620	COG4948	Mandelate Racemase Muconate Lactonizing
AA314_RS24660	COG2378	regulation of single-species biofilm formation
AA314_RS24670	COG4106	trans-aconitate 2-methyltransferase activity
AA314_RS24675	COG0538	isocitrate dehydrogenase activity
AA314_RS24685	COG1053	succinate dehydrogenase
AA314_RS24690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AA314_RS24695	COG0045	succinate-CoA ligase (ADP-forming) activity
AA314_RS24700	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AA314_RS24710	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AA314_RS24715	COG0228	four-way junction DNA binding
AA314_RS24720	COG1837	Belongs to the UPF0109 family
AA314_RS24725	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AA314_RS24730	COG0336	Belongs to the RNA methyltransferase TrmD family
AA314_RS24735	COG0335	large ribosomal subunit rRNA binding
AA314_RS24745	COG0792	nuclease activity
AA314_RS24750	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AA314_RS24765	COG2204	response regulator
AA314_RS24780	COG0728	peptidoglycan biosynthetic process
AA314_RS24785	COG0539	negative regulation of cytoplasmic translation
AA314_RS24840	COG2255	four-way junction helicase activity
AA314_RS24860	COG4191	Histidine kinase
AA314_RS24885	COG0457	Tetratricopeptide repeat
AA314_RS24895	COG2204	response regulator
AA314_RS24920	COG0515	serine threonine protein kinase
AA314_RS24985	COG2085	NADP oxidoreductase coenzyme F420-dependent
AA314_RS24995	COG2366	antibiotic biosynthetic process
AA314_RS25045	COG0693	protein deglycase activity
AA314_RS25045	COG0753	catalase activity
AA314_RS25060	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AA314_RS25085	COG2304	oxidoreductase activity
AA314_RS25110	COG1278	Cold shock
AA314_RS25135	COG0142	geranyltranstransferase activity
AA314_RS25145	COG0545	Peptidyl-prolyl cis-trans isomerase
AA314_RS25170	COG0628	permease
AA314_RS25185	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AA314_RS25195	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AA314_RS25200	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AA314_RS25205	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AA314_RS25210	COG0072	phenylalanine-tRNA ligase activity
AA314_RS25215	COG0776	regulation of translation
AA314_RS25230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA314_RS25235	COG2274	protein secretion by the type I secretion system
AA314_RS25260	COG0840	transmembrane signaling receptor activity
AA314_RS25270	COG2226	methyltransferase
AA314_RS25275	COG4104	PAAR repeat-containing protein
AA314_RS25290	COG1946	Acyl-CoA thioesterase
AA314_RS25305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA314_RS25310	COG1116	anion transmembrane transporter activity
AA314_RS25350	COG1131	(ABC) transporter
AA314_RS25385	COG0525	valine-tRNA ligase activity
AA314_RS25420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA314_RS25490	COG0386	Belongs to the glutathione peroxidase family
AA314_RS25510	COG0726	polysaccharide deacetylase
AA314_RS25590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AA314_RS25620	COG0702	epimerase
AA314_RS25625	COG0657	acetylesterase activity
AA314_RS25670	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS25670	COG3321	synthase
AA314_RS25670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AA314_RS25670	COG4221	oxidoreductase activity
AA314_RS25680	COG1047	Peptidyl-prolyl cis-trans
AA314_RS25745	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AA314_RS25750	COG3281	Trehalose synthase
AA314_RS25760	COG0366	Alpha amylase catalytic
AA314_RS25840	COG2136	Putative SAM-dependent methyltransferase
AA314_RS25840	COG2521	methyltransferase
AA314_RS25845	COG4968	Prepilin-type N-terminal cleavage methylation domain
AA314_RS25865	COG0515	serine threonine protein kinase
AA314_RS25910	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA314_RS25950	COG5001	Diguanylate cyclase
AA314_RS25950	COG3447	MASE1 domain protein
AA314_RS25950	COG5002	protein histidine kinase activity
AA314_RS25965	COG5002	protein histidine kinase activity
AA314_RS25975	COG2124	cytochrome p450
AA314_RS26000	COG1196	nuclear chromosome segregation
AA314_RS26005	COG0612	Peptidase, M16
AA314_RS26015	COG0564	pseudouridine synthase activity
AA314_RS26040	COG2080	2 iron, 2 sulfur cluster binding
AA314_RS26055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA314_RS26065	COG0583	DNA-binding transcription factor activity
AA314_RS26070	COG0697	spore germination
AA314_RS26100	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AA314_RS26135	COG0688	phosphatidylethanolamine metabolic process
AA314_RS26140	COG0124	histidyl-tRNA synthetase
AA314_RS26185	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AA314_RS26205	COG0745	RESPONSE REGULATOR receiver
AA314_RS26230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA314_RS26230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA314_RS26250	COG0142	geranyltranstransferase activity
AA314_RS26255	COG1830	Aldolase
AA314_RS26275	COG1033	growth of symbiont in host cell
AA314_RS26275	COG2409	Drug exporters of the RND superfamily
AA314_RS26295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA314_RS26300	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA314_RS26300	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA314_RS26300	COG1703	isobutyryl-CoA mutase activity
AA314_RS26305	COG1388	LysM domain
AA314_RS26305	COG1705	Flagellar rod assembly protein muramidase FlgJ
AA314_RS26335	COG2319	Wd-40 repeat
AA314_RS26335	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_RS26360	COG1024	Enoyl-CoA hydratase
AA314_RS26370	COG0784	Response regulator, receiver
AA314_RS26400	COG1131	(ABC) transporter
AA314_RS26420	COG3590	peptidase
AA314_RS26445	COG1012	belongs to the aldehyde dehydrogenase family
AA314_RS26450	COG5006	permease, DMT superfamily
AA314_RS26520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_RS26530	COG2319	Wd-40 repeat
AA314_RS26530	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_RS26550	COG0596	Alpha beta hydrolase
AA314_RS26570	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA314_RS26595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA314_RS26670	COG0574	Belongs to the PEP-utilizing enzyme family
AA314_RS26670	COG3848	Pyruvate phosphate dikinase
AA314_RS26685	COG0596	Alpha beta hydrolase
AA314_RS26700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AA314_RS26750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA314_RS26755	COG1960	acyl-CoA dehydrogenase activity
AA314_RS26760	COG0571	ribonuclease III activity
AA314_RS26770	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AA314_RS26775	COG1160	GTP binding
AA314_RS26790	COG0494	nUDIX hydrolase
AA314_RS26815	COG0519	Catalyzes the synthesis of GMP from XMP
AA314_RS26815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AA314_RS26825	COG0516	GMP reductase activity
AA314_RS26825	COG0517	IMP dehydrogenase activity
AA314_RS26830	COG0443	Heat shock 70 kDa protein
AA314_RS26835	COG0586	Pfam SNARE associated Golgi protein
AA314_RS26845	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AA314_RS26850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA314_RS26865	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS26880	COG0720	synthase
AA314_RS26885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AA314_RS26890	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AA314_RS26895	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AA314_RS26900	COG0183	Belongs to the thiolase family
AA314_RS26910	COG1960	acyl-CoA dehydrogenase activity
AA314_RS26920	COG1960	acyl-CoA dehydrogenase activity
AA314_RS26925	COG1024	Enoyl-CoA hydratase
AA314_RS26930	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA314_RS26945	COG0489	protein tyrosine kinase activity
AA314_RS27010	COG0776	regulation of translation
AA314_RS27035	COG0583	DNA-binding transcription factor activity
AA314_RS27040	COG0604	alcohol dehydrogenase
AA314_RS27040	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS27040	COG3321	synthase
AA314_RS27050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AA314_RS27060	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AA314_RS27100	COG2124	cytochrome p450
AA314_RS27105	COG4566	intracellular signal transduction
AA314_RS27115	COG0626	cystathionine gamma-synthase activity
AA314_RS27130	COG0412	Dienelactone hydrolase
AA314_RS27150	COG1131	(ABC) transporter
AA314_RS27165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA314_RS27190	COG3227	Zinc metalloprotease (Elastase)
AA314_RS27195	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AA314_RS27215	COG0534	Mate efflux family protein
AA314_RS27235	COG0004	ammonium transporteR
AA314_RS27245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA314_RS27260	COG2378	regulation of single-species biofilm formation
AA314_RS27280	COG0745	RESPONSE REGULATOR receiver
AA314_RS27315	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AA314_RS27340	COG1309	transcriptional regulator
AA314_RS27360	COG2124	cytochrome p450
AA314_RS27395	COG5002	protein histidine kinase activity
AA314_RS27425	COG2205	protein histidine kinase activity
AA314_RS27430	COG0745	RESPONSE REGULATOR receiver
AA314_RS27450	COG0531	amino acid
AA314_RS27460	COG0477	Major facilitator Superfamily
AA314_RS27545	COG0542	response to heat
AA314_RS27550	COG0542	response to heat
AA314_RS27600	COG0430	RNA-3'-phosphate cyclase activity
AA314_RS27615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_RS27625	COG1187	pseudouridine synthase activity
AA314_RS27630	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AA314_RS27635	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AA314_RS27660	COG4974	Belongs to the 'phage' integrase family
AA314_RS27715	COG0009	L-threonylcarbamoyladenylate synthase
AA314_RS27720	COG0475	glutathione-regulated potassium exporter activity
AA314_RS27720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA314_RS27745	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AA314_RS27795	COG0860	N-Acetylmuramoyl-L-alanine amidase
AA314_RS27815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AA314_RS27825	COG5520	Belongs to the glycosyl hydrolase 30 family
AA314_RS27825	COG4447	cellulose binding
AA314_RS27825	COG3291	Pkd domain containing protein
AA314_RS27830	COG3831	ATPase activity
AA314_RS27840	COG2205	protein histidine kinase activity
AA314_RS27840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA314_RS27845	COG0714	Associated with various cellular activities
AA314_RS27850	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AA314_RS27855	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AA314_RS27870	COG1695	Transcriptional regulator
AA314_RS27875	COG5002	protein histidine kinase activity
AA314_RS27885	COG0006	proline dipeptidase activity
AA314_RS27905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AA314_RS27925	COG2706	6-phosphogluconolactonase activity
AA314_RS27930	COG0784	Response regulator, receiver
AA314_RS27930	COG2205	protein histidine kinase activity
AA314_RS28095	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AA314_RS28100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AA314_RS28115	COG0515	serine threonine protein kinase
AA314_RS28135	COG3227	Zinc metalloprotease (Elastase)
AA314_RS28140	COG3227	Zinc metalloprotease (Elastase)
AA314_RS28175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AA314_RS28190	COG1595	DNA-templated transcription, initiation
AA314_RS28225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AA314_RS28230	COG1116	anion transmembrane transporter activity
AA314_RS28235	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AA314_RS28275	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AA314_RS28295	COG5002	protein histidine kinase activity
AA314_RS28310	COG0515	serine threonine protein kinase
AA314_RS28310	COG2815	serine threonine protein kinase
AA314_RS28325	COG0585	pseudouridine synthase activity
AA314_RS28330	COG1595	DNA-templated transcription, initiation
AA314_RS28360	COG0300	oxidoreductase activity
AA314_RS28400	COG3239	Fatty acid desaturase
AA314_RS28415	COG0708	Exodeoxyribonuclease III
AA314_RS28420	COG0515	serine threonine protein kinase
AA314_RS28430	COG0667	Aldo Keto reductase
AA314_RS28455	COG0596	Alpha beta hydrolase
AA314_RS28460	COG0667	Aldo Keto reductase
AA314_RS28490	COG1960	acyl-CoA dehydrogenase activity
AA314_RS28495	COG1073	alpha beta
AA314_RS28575	COG0488	(ABC) transporter
AA314_RS28620	COG0463	Glycosyl transferase, family 2
AA314_RS28705	COG2234	aminopeptidase activity
AA314_RS28710	COG0667	Aldo Keto reductase
AA314_RS28720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA314_RS28735	COG2894	cell division
AA314_RS28745	COG0515	serine threonine protein kinase
AA314_RS28745	COG2815	serine threonine protein kinase
AA314_RS28755	COG2204	response regulator
AA314_RS28780	COG0628	permease
AA314_RS28790	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AA314_RS28795	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AA314_RS28800	COG1438	arginine binding
AA314_RS28805	COG0165	Argininosuccinate lyase
AA314_RS28810	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AA314_RS28830	COG2027	D-alanyl-D-alanine carboxypeptidase
AA314_RS28835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AA314_RS28855	COG0436	Aminotransferase
AA314_RS28860	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AA314_RS28865	COG0742	ribosomal rna small subunit methyltransferase
AA314_RS28900	COG1217	gtp-binding protein TYPA
AA314_RS28910	COG0217	transcriptional regulatory protein
AA314_RS28935	COG1858	cytochrome C peroxidase
AA314_RS28940	COG2207	Transcriptional regulator
AA314_RS28965	COG0477	Major facilitator Superfamily
AA314_RS28980	COG1741	Belongs to the pirin family
AA314_RS28985	COG0506	proline dehydrogenase activity
AA314_RS29045	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AA314_RS29070	COG0741	lytic transglycosylase activity
AA314_RS29070	COG0739	heme binding
AA314_RS29070	COG1196	nuclear chromosome segregation
AA314_RS29090	COG0714	Associated with various cellular activities
AA314_RS29105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA314_RS29110	COG1297	OPT oligopeptide transporter protein
AA314_RS29145	COG0493	'glutamate synthase
AA314_RS29145	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AA314_RS29155	COG0564	pseudouridine synthase activity
AA314_RS29185	COG1921	L-seryl-tRNASec selenium transferase activity
AA314_RS29190	COG0741	lytic transglycosylase activity
AA314_RS29195	COG4191	Histidine kinase
AA314_RS29215	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AA314_RS29250	COG0488	(ABC) transporter
AA314_RS29265	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AA314_RS29270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AA314_RS29275	COG0825	malonyl-CoA metabolic process
AA314_RS29315	COG2766	serine protein kinase
AA314_RS29325	COG0443	Heat shock 70 kDa protein
AA314_RS29350	COG0101	tRNA pseudouridine synthase activity
AA314_RS29355	COG1606	tRNA processing
AA314_RS29360	COG2046	Belongs to the sulfate adenylyltransferase family
AA314_RS29360	COG0529	Catalyzes the synthesis of activated sulfate
AA314_RS29380	COG0425	Belongs to the sulfur carrier protein TusA family
AA314_RS29385	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AA314_RS29395	COG4585	Histidine kinase
AA314_RS29440	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AA314_RS29455	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA314_RS29470	COG0113	porphobilinogen synthase activity
AA314_RS29480	COG1131	(ABC) transporter
AA314_RS29495	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AA314_RS29550	COG0745	RESPONSE REGULATOR receiver
AA314_RS29560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AA314_RS29565	COG0686	Belongs to the AlaDH PNT family
AA314_RS29570	COG1595	DNA-templated transcription, initiation
AA314_RS29610	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AA314_RS29615	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AA314_RS29615	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AA314_RS29620	COG0460	homoserine dehydrogenase
AA314_RS29645	COG2070	2-Nitropropane dioxygenase
AA314_RS29655	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA314_RS29665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA314_RS29670	COG0572	uridine kinase
AA314_RS29700	COG1595	DNA-templated transcription, initiation
AA314_RS29705	COG2391	methyltransferase activity
AA314_RS29720	COG0427	acetyl-CoA hydrolase
AA314_RS29725	COG5002	protein histidine kinase activity
AA314_RS29725	COG5001	Diguanylate cyclase
AA314_RS29725	COG3447	MASE1 domain protein
AA314_RS29730	COG1063	alcohol dehydrogenase
AA314_RS29785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA314_RS29790	COG1803	Methylglyoxal synthase
AA314_RS29870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AA314_RS29875	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS29890	COG1309	transcriptional regulator
AA314_RS29910	COG0544	peptidyl-prolyl cis-trans isomerase activity
AA314_RS29955	COG0475	glutathione-regulated potassium exporter activity
AA314_RS29955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA314_RS29960	COG0583	DNA-binding transcription factor activity
AA314_RS29990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AA314_RS30005	COG2124	cytochrome p450
AA314_RS30010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AA314_RS30030	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA314_RS30035	COG0577	efflux transmembrane transporter activity
AA314_RS30035	COG1136	(ABC) transporter
AA314_RS30040	COG0577	efflux transmembrane transporter activity
AA314_RS30040	COG1136	(ABC) transporter
AA314_RS30045	COG0577	efflux transmembrane transporter activity
AA314_RS30045	COG1136	(ABC) transporter
AA314_RS30065	COG0542	response to heat
AA314_RS30175	COG0457	Tetratricopeptide repeat
AA314_RS30175	COG0515	serine threonine protein kinase
AA314_RS30210	COG2205	protein histidine kinase activity
AA314_RS30215	COG0745	RESPONSE REGULATOR receiver
AA314_RS30270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AA314_RS30280	COG3876	Protein conserved in bacteria
AA314_RS30295	COG1193	negative regulation of DNA recombination
AA314_RS30300	COG0515	serine threonine protein kinase
AA314_RS30310	COG0557	exoribonuclease II activity
AA314_RS30320	COG0303	'Molybdopterin
AA314_RS30325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA314_RS30325	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA314_RS30350	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AA314_RS30360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA314_RS30380	COG0557	exoribonuclease II activity
AA314_RS30385	COG0739	heme binding
AA314_RS30420	COG0107	imidazoleglycerol-phosphate synthase activity
AA314_RS30425	COG0131	Imidazoleglycerol-phosphate dehydratase
AA314_RS30430	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AA314_RS30435	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AA314_RS30445	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AA314_RS30450	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AA314_RS30455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA314_RS30455	COG2022	thiamine diphosphate biosynthetic process
AA314_RS30465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AA314_RS30475	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AA314_RS30480	COG0517	IMP dehydrogenase activity
AA314_RS30480	COG0516	GMP reductase activity
AA314_RS30500	COG2204	response regulator
AA314_RS30505	COG4191	Histidine kinase
AA314_RS30510	COG0745	RESPONSE REGULATOR receiver
AA314_RS30510	COG4566	intracellular signal transduction
AA314_RS30515	COG2205	protein histidine kinase activity
AA314_RS30535	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AA314_RS30580	COG1335	isochorismatase
AA314_RS30635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AA314_RS30655	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AA314_RS30680	COG0515	serine threonine protein kinase
AA314_RS30680	COG2815	serine threonine protein kinase
AA314_RS30745	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AA314_RS30750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AA314_RS30755	COG0489	protein tyrosine kinase activity
AA314_RS30820	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AA314_RS30880	COG1278	Cold shock
AA314_RS30920	COG1595	DNA-templated transcription, initiation
AA314_RS30945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA314_RS30960	COG2204	response regulator
AA314_RS30965	COG3706	GGDEF domain
AA314_RS30985	COG0564	pseudouridine synthase activity
AA314_RS31005	COG1131	(ABC) transporter
AA314_RS31010	COG0425	Belongs to the sulfur carrier protein TusA family
AA314_RS31015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AA314_RS31015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AA314_RS31060	COG1454	alcohol dehydrogenase
AA314_RS31085	COG0443	Heat shock 70 kDa protein
AA314_RS31105	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AA314_RS31110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA314_RS31130	COG0535	radical SAM domain protein
AA314_RS31150	COG2272	Belongs to the type-B carboxylesterase lipase family
AA314_RS31165	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS31170	COG3304	Inner membrane component domain
AA314_RS31185	COG4104	PAAR repeat-containing protein
AA314_RS31200	COG0577	efflux transmembrane transporter activity
AA314_RS31200	COG1136	(ABC) transporter
AA314_RS31210	COG0436	Aminotransferase
AA314_RS31225	COG4191	Histidine kinase
AA314_RS31230	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA314_RS31230	COG1672	PFAM Archaeal ATPase
AA314_RS31345	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AA314_RS31345	COG2755	lipolytic protein G-D-S-L family
AA314_RS31350	COG2354	Protein conserved in bacteria
AA314_RS31355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA314_RS31380	COG0583	DNA-binding transcription factor activity
AA314_RS31385	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS31415	COG0596	Alpha beta hydrolase
AA314_RS31460	COG5002	protein histidine kinase activity
AA314_RS31480	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AA314_RS31490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA314_RS31495	COG3940	Belongs to the glycosyl hydrolase 43 family
AA314_RS31535	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AA314_RS31540	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AA314_RS31550	COG0175	sulfate reduction
AA314_RS31555	COG1648	precorrin-2 dehydrogenase activity
AA314_RS31555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AA314_RS31560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AA314_RS31560	COG1648	precorrin-2 dehydrogenase activity
AA314_RS31570	COG0175	sulfate reduction
AA314_RS31580	COG1672	PFAM Archaeal ATPase
AA314_RS31580	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA314_RS31585	COG1295	ribonuclease BN
AA314_RS31585	COG1959	2 iron, 2 sulfur cluster binding
AA314_RS31600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_RS31615	COG2133	pyrroloquinoline quinone binding
AA314_RS31620	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS31635	COG0745	RESPONSE REGULATOR receiver
AA314_RS31665	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA314_RS31690	COG1999	signal sequence binding
AA314_RS31730	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AA314_RS31765	COG2897	thiosulfate sulfurtransferase activity
AA314_RS31775	COG2226	methyltransferase
AA314_RS31800	COG2197	response regulator
AA314_RS31805	COG0071	Belongs to the small heat shock protein (HSP20) family
AA314_RS31875	COG0484	heat shock protein binding
AA314_RS31880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AA314_RS31925	COG1450	Type ii and iii secretion system protein
AA314_RS31950	COG0751	glycine-tRNA ligase activity
AA314_RS31955	COG0752	glycyl-tRNA synthetase alpha subunit
AA314_RS31970	COG1381	Involved in DNA repair and RecF pathway recombination
AA314_RS32005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AA314_RS32010	COG0085	RNA polymerase activity
AA314_RS32015	COG0222	ribosome binding
AA314_RS32020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AA314_RS32025	COG0081	regulation of translation
AA314_RS32030	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AA314_RS32050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AA314_RS32055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AA314_RS32080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AA314_RS32120	COG1643	Atp-dependent helicase
AA314_RS32150	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AA314_RS32160	COG1960	acyl-CoA dehydrogenase activity
AA314_RS32190	COG1064	alcohol dehydrogenase
AA314_RS32205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AA314_RS32205	COG0047	phosphoribosylformylglycinamidine synthase activity
AA314_RS32215	COG3383	formate dehydrogenase (NAD+) activity
AA314_RS32225	COG2226	methyltransferase
AA314_RS32270	COG2385	sporulation resulting in formation of a cellular spore
AA314_RS32295	COG2205	protein histidine kinase activity
AA314_RS32305	COG2080	2 iron, 2 sulfur cluster binding
AA314_RS32310	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AA314_RS32315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AA314_RS32345	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA314_RS32345	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA314_RS32350	COG0509	glycine decarboxylation via glycine cleavage system
AA314_RS32355	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA314_RS32360	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AA314_RS32370	COG0596	Alpha beta hydrolase
AA314_RS32380	COG4771	TonB-dependent receptor
AA314_RS32390	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AA314_RS32395	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AA314_RS32405	COG0626	cystathionine gamma-synthase activity
AA314_RS32410	COG0626	cystathionine gamma-synthase activity
AA314_RS32415	COG0527	aspartate kinase activity
AA314_RS32415	COG0460	homoserine dehydrogenase
AA314_RS32440	COG2840	Smr protein MutS2
AA314_RS32445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AA314_RS32450	COG0167	dihydroorotate dehydrogenase activity
AA314_RS32455	COG2124	cytochrome p450
AA314_RS32460	COG4977	sequence-specific DNA binding
AA314_RS32490	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AA314_RS32505	COG0237	dephospho-CoA kinase activity
AA314_RS32530	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AA314_RS32535	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AA314_RS32540	COG5464	transposase or invertase
AA314_RS32555	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AA314_RS32580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AA314_RS32600	COG1496	oxidoreductase activity
AA314_RS32615	COG1543	Belongs to the glycosyl hydrolase 57 family
AA314_RS32625	COG0438	transferase activity, transferring glycosyl groups
AA314_RS32630	COG1196	nuclear chromosome segregation
AA314_RS32630	COG0745	RESPONSE REGULATOR receiver
AA314_RS32645	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AA314_RS32655	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AA314_RS32665	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AA314_RS32670	COG1227	inorganic diphosphatase activity
AA314_RS32685	COG0515	serine threonine protein kinase
AA314_RS32700	COG1692	metallophosphoesterase
AA314_RS32705	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AA314_RS32715	COG2135	peptidase activity
AA314_RS32725	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AA314_RS32750	COG5002	protein histidine kinase activity
AA314_RS32760	COG1960	acyl-CoA dehydrogenase activity
AA314_RS32795	COG0604	alcohol dehydrogenase
AA314_RS32795	COG3321	synthase
AA314_RS32805	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS32805	COG3321	synthase
AA314_RS32805	COG0604	alcohol dehydrogenase
AA314_RS32810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA314_RS32820	COG0745	RESPONSE REGULATOR receiver
AA314_RS32830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AA314_RS32835	COG1022	Amp-dependent synthetase and ligase
AA314_RS32845	COG0277	FAD linked oxidase domain protein
AA314_RS32850	COG0302	gtp cyclohydrolase
AA314_RS32880	COG1121	(ABC) transporter
AA314_RS32920	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_RS32920	COG2319	Wd-40 repeat
AA314_RS32930	COG2319	Wd-40 repeat
AA314_RS32930	COG1672	PFAM Archaeal ATPase
AA314_RS32935	COG1335	isochorismatase
AA314_RS32940	COG0517	IMP dehydrogenase activity
AA314_RS32990	COG0670	Belongs to the BI1 family
AA314_RS33000	COG3411	Ferredoxin
AA314_RS33005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AA314_RS33025	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AA314_RS33030	COG0297	glycogen (starch) synthase activity
AA314_RS33035	COG0438	transferase activity, transferring glycosyl groups
AA314_RS33040	COG4335	DNA alkylation repair
AA314_RS33045	COG0322	excinuclease ABC activity
AA314_RS33050	COG0745	RESPONSE REGULATOR receiver
AA314_RS33055	COG3620	sequence-specific DNA binding
AA314_RS33070	COG2815	serine threonine protein kinase
AA314_RS33070	COG0515	serine threonine protein kinase
AA314_RS33085	COG0795	lipopolysaccharide-transporting ATPase activity
AA314_RS33090	COG0151	Belongs to the GarS family
AA314_RS33100	COG0138	bifunctional purine biosynthesis protein purh
AA314_RS33105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA314_RS33115	COG0515	serine threonine protein kinase
AA314_RS33120	COG0515	serine threonine protein kinase
AA314_RS33160	COG0351	phosphomethylpyrimidine kinase
AA314_RS33170	COG4191	Histidine kinase
AA314_RS33185	COG0457	Tetratricopeptide repeat
AA314_RS33185	COG0515	serine threonine protein kinase
AA314_RS33195	COG3852	Histidine kinase
AA314_RS33205	COG0577	efflux transmembrane transporter activity
AA314_RS33205	COG1136	(ABC) transporter
AA314_RS33215	COG1136	(ABC) transporter
AA314_RS33225	COG2304	oxidoreductase activity
AA314_RS33245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA314_RS33255	COG0840	transmembrane signaling receptor activity
AA314_RS33260	COG2890	protein-(glutamine-N5) methyltransferase activity
AA314_RS33265	COG1793	dna ligase
AA314_RS33300	COG1012	belongs to the aldehyde dehydrogenase family
AA314_RS33310	COG0583	DNA-binding transcription factor activity
AA314_RS33315	COG0427	acetyl-CoA hydrolase
AA314_RS33330	COG0840	transmembrane signaling receptor activity
AA314_RS33335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA314_RS33360	COG0149	triose-phosphate isomerase activity
AA314_RS33365	COG0126	phosphoglycerate kinase activity
AA314_RS33370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AA314_RS33380	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AA314_RS33390	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AA314_RS33415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AA314_RS33420	COG0084	hydrolase, TatD family'
AA314_RS33430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA314_RS33430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA314_RS33460	COG2208	phosphoserine phosphatase activity
AA314_RS33465	COG0596	Alpha beta hydrolase
AA314_RS33470	COG1522	sequence-specific DNA binding
AA314_RS33495	COG2124	cytochrome p450
AA314_RS33555	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AA314_RS33590	COG0243	molybdopterin cofactor binding
AA314_RS33620	COG0521	Mo-molybdopterin cofactor biosynthetic process
AA314_RS33635	COG1796	DNA polymerase
AA314_RS33635	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AA314_RS33655	COG0443	Heat shock 70 kDa protein
AA314_RS33660	COG0484	heat shock protein binding
AA314_RS33670	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AA314_RS33675	COG1166	arginine decarboxylase activity
AA314_RS33710	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AA314_RS33715	COG0438	transferase activity, transferring glycosyl groups
AA314_RS33725	COG1408	metallophosphoesterase
AA314_RS33770	COG1899	peptidyl-lysine modification to peptidyl-hypusine
AA314_RS33780	COG0613	PHP domain protein
AA314_RS33785	COG2124	cytochrome p450
AA314_RS33810	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA314_RS33815	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA314_RS33825	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA314_RS33830	COG0649	NAD binding
AA314_RS33835	COG1034	ATP synthesis coupled electron transport
AA314_RS33840	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AA314_RS33845	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA314_RS33910	COG3246	L-lysine catabolic process to acetate
AA314_RS33915	COG1024	Enoyl-CoA hydratase
AA314_RS33920	COG1309	transcriptional regulator
AA314_RS33930	COG1396	sequence-specific DNA binding
AA314_RS33950	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AA314_RS33960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_RS33965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AA314_RS33970	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AA314_RS33975	COG1683	Conserved Protein
AA314_RS33980	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AA314_RS34005	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AA314_RS34010	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AA314_RS34030	COG1473	amidohydrolase
AA314_RS34065	COG1100	Small GTP-binding protein
AA314_RS34070	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AA314_RS34165	COG2814	Major facilitator Superfamily
AA314_RS34185	COG1760	l-serine dehydratase
AA314_RS34210	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS34295	COG0596	Alpha beta hydrolase
AA314_RS34300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AA314_RS34300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AA314_RS34300	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AA314_RS34305	COG1105	Belongs to the carbohydrate kinase PfkB family
AA314_RS34310	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AA314_RS34310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AA314_RS34315	COG1609	Transcriptional regulator
AA314_RS34320	COG0667	Aldo Keto reductase
AA314_RS34325	COG1024	Enoyl-CoA hydratase
AA314_RS34325	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA314_RS34330	COG1960	acyl-CoA dehydrogenase activity
AA314_RS34340	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AA314_RS34345	COG0352	thiamine-phosphate diphosphorylase activity
AA314_RS34355	COG2815	serine threonine protein kinase
AA314_RS34355	COG0515	serine threonine protein kinase
AA314_RS34370	COG4213	ABC transporter substrate-binding protein
AA314_RS34380	COG4214	carbohydrate transport
AA314_RS34395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AA314_RS34455	COG0312	modulator of DNA gyrase
AA314_RS34460	COG4221	oxidoreductase activity
AA314_RS34480	COG4681	YaeQ
AA314_RS34505	COG0586	Pfam SNARE associated Golgi protein
AA314_RS34520	COG0784	Response regulator, receiver
AA314_RS34565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA314_RS34600	COG4191	Histidine kinase
AA314_RS34615	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA314_RS34620	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA314_RS34620	COG0022	dehydrogenase e1 component
AA314_RS34625	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AA314_RS34640	COG0475	glutathione-regulated potassium exporter activity
AA314_RS34645	COG1396	sequence-specific DNA binding
AA314_RS34650	COG0475	glutathione-regulated potassium exporter activity
AA314_RS34665	COG0737	Belongs to the 5'-nucleotidase family
AA314_RS34695	COG0312	modulator of DNA gyrase
AA314_RS34700	COG0312	modulator of DNA gyrase
AA314_RS34705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AA314_RS34725	COG0181	hydroxymethylbilane synthase activity
AA314_RS34730	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AA314_RS34735	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AA314_RS34745	COG3118	belongs to the thioredoxin family
AA314_RS34755	COG2239	Acts as a magnesium transporter
AA314_RS34765	COG0772	Belongs to the SEDS family
AA314_RS34785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AA314_RS34810	COG3706	GGDEF domain
AA314_RS34815	COG0424	maF-like protein
AA314_RS34865	COG0322	excinuclease ABC activity
AA314_RS34870	COG0556	nucleotide-excision repair
AA314_RS34885	COG0215	cysteine-tRNA ligase activity
AA314_RS34890	COG1716	ATPase activity
AA314_RS34900	COG1329	Transcriptional regulator
AA314_RS34905	COG2333	competence protein COMEC
AA314_RS34905	COG0658	competence protein
AA314_RS34930	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AA314_RS34935	COG1074	ATP-dependent DNA helicase activity
AA314_RS34960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA314_RS35000	COG0745	RESPONSE REGULATOR receiver
AA314_RS35005	COG1819	glycosyl
AA314_RS35055	COG3104	oligopeptide transport
AA314_RS35075	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AA314_RS35120	COG0584	glycerophosphoryl diester phosphodiesterase
AA314_RS35130	COG1607	acyl-coa hydrolase
AA314_RS35135	COG2205	protein histidine kinase activity
AA314_RS35145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AA314_RS35155	COG0515	serine threonine protein kinase
AA314_RS35180	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AA314_RS35190	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AA314_RS35205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AA314_RS35235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA314_RS35235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA314_RS35260	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AA314_RS35275	COG3550	peptidyl-serine autophosphorylation
AA314_RS35290	COG0750	zinc metalloprotease
AA314_RS35300	COG0314	molybdopterin synthase activity
AA314_RS35320	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AA314_RS35340	COG0544	peptidyl-prolyl cis-trans isomerase activity
AA314_RS35360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AA314_RS35365	COG0750	zinc metalloprotease
AA314_RS35370	COG4589	Belongs to the CDS family
AA314_RS35375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AA314_RS35385	COG0564	pseudouridine synthase activity
AA314_RS35390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AA314_RS35400	COG0617	tRNA 3'-terminal CCA addition
AA314_RS35410	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AA314_RS35415	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AA314_RS35430	COG0372	Belongs to the citrate synthase family
AA314_RS35435	COG2124	cytochrome p450
AA314_RS35455	COG0673	inositol 2-dehydrogenase activity
AA314_RS35490	COG0243	molybdopterin cofactor binding
AA314_RS35505	COG0437	4 iron, 4 sulfur cluster binding
AA314_RS35515	COG3916	Acyl-homoserine-lactone synthase
AA314_RS35520	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AA314_RS35525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA314_RS35540	COG1917	Cupin 2, conserved barrel domain protein
AA314_RS35545	COG0583	DNA-binding transcription factor activity
AA314_RS35550	COG0740	serine-type endopeptidase activity
AA314_RS35595	COG0416	fatty acid biosynthetic process
AA314_RS35630	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AA314_RS35635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AA314_RS35645	COG1063	alcohol dehydrogenase
AA314_RS35650	COG0596	Alpha beta hydrolase
AA314_RS35655	COG2205	protein histidine kinase activity
AA314_RS35655	COG0784	Response regulator, receiver
AA314_RS35660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AA314_RS35695	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AA314_RS35745	COG2353	YceI-like domain
AA314_RS35750	COG0583	DNA-binding transcription factor activity
AA314_RS35755	COG1741	Belongs to the pirin family
AA314_RS35770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AA314_RS35775	COG1858	cytochrome C peroxidase
AA314_RS35795	COG0612	Peptidase, M16
AA314_RS35805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA314_RS35840	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS35845	COG0583	DNA-binding transcription factor activity
AA314_RS35890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AA314_RS35895	COG1459	type II secretion system
AA314_RS35950	COG1595	DNA-templated transcription, initiation
AA314_RS35960	COG4990	cell redox homeostasis
AA314_RS35960	COG3591	Belongs to the peptidase S1B family
AA314_RS35970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA314_RS35980	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AA314_RS35985	COG0187	DNA topoisomerase II activity
AA314_RS36000	COG0616	signal peptide processing
AA314_RS36005	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AA314_RS36010	COG2267	carboxylic ester hydrolase activity
AA314_RS36020	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AA314_RS36030	COG0516	GMP reductase activity
AA314_RS36030	COG0517	IMP dehydrogenase activity
AA314_RS36095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AA314_RS36115	COG0714	Associated with various cellular activities
AA314_RS36170	COG4305	rare lipoprotein A
AA314_RS36200	COG2204	response regulator
AA314_RS36205	COG0515	serine threonine protein kinase
AA314_RS36205	COG2815	serine threonine protein kinase
AA314_RS36270	COG1716	ATPase activity
AA314_RS36275	COG4789	Type iii secretion
AA314_RS36305	COG0471	metal ion transport
AA314_RS36305	COG3273	potassium ion transport
AA314_RS36360	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AA314_RS36365	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AA314_RS36380	COG1338	Plays a role in the flagellum-specific transport system
AA314_RS36390	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AA314_RS36390	COG1776	CheC inhibitor of MCP methylation
AA314_RS36405	COG1157	protein secretion by the type III secretion system
AA314_RS36410	COG1317	bacterial-type flagellum organization
AA314_RS36420	COG4669	(LipO)protein
AA314_RS36430	COG1191	sigma factor activity
AA314_RS36465	COG1136	(ABC) transporter
AA314_RS36475	COG1136	(ABC) transporter
AA314_RS36475	COG0577	efflux transmembrane transporter activity
AA314_RS36500	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AA314_RS36520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA314_RS36565	COG0456	acetyltransferase
AA314_RS36595	COG1187	pseudouridine synthase activity
AA314_RS36605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AA314_RS36610	COG0513	Belongs to the DEAD box helicase family
AA314_RS36615	COG0488	(ABC) transporter
AA314_RS36620	COG0488	(ABC) transporter
AA314_RS36635	COG0277	FAD linked oxidase domain protein
AA314_RS36650	COG1047	Peptidyl-prolyl cis-trans
AA314_RS36655	COG1301	dicarboxylic acid transport
AA314_RS36680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AA314_RS36710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA314_RS36720	COG0596	Alpha beta hydrolase
AA314_RS36730	COG1960	acyl-CoA dehydrogenase activity
AA314_RS36735	COG0076	glutamate decarboxylase activity
AA314_RS36850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA314_RS36860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_RS36870	COG0515	serine threonine protein kinase
AA314_RS36880	COG1362	aminopeptidase activity
AA314_RS36915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA314_RS36965	COG1045	serine acetyltransferase
AA314_RS37020	COG0515	serine threonine protein kinase
AA314_RS37040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA314_RS37050	COG0823	Involved in the tonB-independent uptake of proteins
AA314_RS37050	COG1506	peptidase
AA314_RS37060	COG2363	Small membrane protein
AA314_RS37075	COG2205	protein histidine kinase activity
AA314_RS37080	COG3850	Histidine kinase
AA314_RS37080	COG3437	response regulator, receiver
AA314_RS37080	COG2205	protein histidine kinase activity
AA314_RS37080	COG4999	Histidine kinase
AA314_RS37085	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AA314_RS37095	COG1032	radical SAM domain protein
AA314_RS37105	COG0546	phosphoglycolate phosphatase activity
AA314_RS37120	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS37160	COG0745	RESPONSE REGULATOR receiver
AA314_RS37165	COG2201	protein-glutamate methylesterase activity
AA314_RS37175	COG0840	transmembrane signaling receptor activity
AA314_RS37185	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AA314_RS37205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AA314_RS37250	COG2205	protein histidine kinase activity
AA314_RS37265	COG0300	oxidoreductase activity
AA314_RS37275	COG0628	permease
AA314_RS37330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_RS37330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA314_RS37345	COG0681	Belongs to the peptidase S26 family
AA314_RS37355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AA314_RS37365	COG4968	Prepilin-type N-terminal cleavage methylation domain
AA314_RS37435	COG1404	Belongs to the peptidase S8 family
AA314_RS37465	COG1162	GTPase activity
AA314_RS37505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA314_RS37525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AA314_RS37535	COG0823	Involved in the tonB-independent uptake of proteins
AA314_RS37545	COG2373	Large extracellular alpha-helical protein
AA314_RS37550	COG4953	penicillin-binding protein 1C
AA314_RS37555	COG0454	-acetyltransferase
AA314_RS37560	COG2226	methyltransferase
AA314_RS37580	COG2815	serine threonine protein kinase
AA314_RS37580	COG0515	serine threonine protein kinase
AA314_RS37605	COG3227	Zinc metalloprotease (Elastase)
AA314_RS37610	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA314_RS37635	COG2832	Protein of unknown function (DUF454)
AA314_RS37680	COG1744	ABC transporter substrate-binding protein PnrA-like
AA314_RS37695	COG1131	(ABC) transporter
AA314_RS37705	COG3118	belongs to the thioredoxin family
AA314_RS37710	COG2879	small protein
AA314_RS37715	COG1966	Carbon starvation protein
AA314_RS37830	COG0574	Belongs to the PEP-utilizing enzyme family
AA314_RS37830	COG3848	Pyruvate phosphate dikinase
AA314_RS37845	COG0515	serine threonine protein kinase
AA314_RS37845	COG2815	serine threonine protein kinase
AA314_RS37865	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AA314_RS37875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA314_RS37880	COG0604	alcohol dehydrogenase
AA314_RS37905	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AA314_RS37920	COG2124	cytochrome p450
AA314_RS37920	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AA314_RS37935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AA314_RS37950	COG0395	ABC-type sugar transport system, permease component
AA314_RS37955	COG1175	transmembrane transport
AA314_RS37985	COG0423	glycine-tRNA ligase activity
AA314_RS38050	COG1960	acyl-CoA dehydrogenase activity
AA314_RS38055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA314_RS38065	COG0840	transmembrane signaling receptor activity
AA314_RS38070	COG1012	belongs to the aldehyde dehydrogenase family
AA314_RS38095	COG0402	S-adenosylhomocysteine deaminase activity
AA314_RS38100	COG0515	serine threonine protein kinase
AA314_RS38115	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS38185	COG0300	oxidoreductase activity
AA314_RS38190	COG1733	regulation of RNA biosynthetic process
AA314_RS38195	COG0300	oxidoreductase activity
AA314_RS38240	COG0612	Peptidase, M16
AA314_RS38300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA314_RS38330	COG0840	transmembrane signaling receptor activity
AA314_RS38395	COG0697	spore germination
AA314_RS38420	COG0583	DNA-binding transcription factor activity
AA314_RS38435	COG2319	Wd-40 repeat
AA314_RS38435	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_RS38445	COG2267	carboxylic ester hydrolase activity
AA314_RS38455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA314_RS38465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AA314_RS38475	COG2815	serine threonine protein kinase
AA314_RS38475	COG0515	serine threonine protein kinase
AA314_RS38480	COG0756	dUTP diphosphatase activity
AA314_RS38490	COG0739	heme binding
AA314_RS38500	COG3344	reverse transcriptase
AA314_RS38505	COG1185	polyribonucleotide nucleotidyltransferase activity
AA314_RS38510	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AA314_RS38515	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AA314_RS38540	COG0779	Required for maturation of 30S ribosomal subunits
AA314_RS38560	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AA314_RS38580	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AA314_RS38585	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AA314_RS38590	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AA314_RS38595	COG1428	Deoxynucleoside kinase
AA314_RS38610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AA314_RS38615	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AA314_RS38655	COG0631	protein serine/threonine phosphatase activity
AA314_RS38670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AA314_RS38685	COG1971	Probably functions as a manganese efflux pump
AA314_RS38690	COG5002	protein histidine kinase activity
AA314_RS38690	COG2198	Histidine kinase
AA314_RS38690	COG0784	Response regulator, receiver
AA314_RS38695	COG0745	RESPONSE REGULATOR receiver
AA314_RS38705	COG0339	signal peptide processing
AA314_RS38735	COG0583	DNA-binding transcription factor activity
AA314_RS38740	COG0823	Involved in the tonB-independent uptake of proteins
AA314_RS38740	COG1506	peptidase
AA314_RS38815	COG5002	protein histidine kinase activity
AA314_RS38830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA314_RS38840	COG0626	cystathionine gamma-synthase activity
AA314_RS38860	COG3030	protein affecting phage T7 exclusion by the F plasmid
AA314_RS38870	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AA314_RS38885	COG1929	Belongs to the glycerate kinase type-1 family
AA314_RS38935	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AA314_RS38965	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AA314_RS39000	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AA314_RS39030	COG0745	RESPONSE REGULATOR receiver
AA314_RS39035	COG1024	Enoyl-CoA hydratase
AA314_RS39040	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AA314_RS39045	COG0439	Biotin carboxylase
AA314_RS39055	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AA314_RS39075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA314_RS39125	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AA314_RS39130	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA314_RS39135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AA314_RS39140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AA314_RS39145	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AA314_RS39150	COG0772	Belongs to the SEDS family
AA314_RS39155	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AA314_RS39160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AA314_RS39165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AA314_RS39170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AA314_RS39180	COG3116	cell division
AA314_RS39185	COG0275	rRNA processing
AA314_RS39195	COG2001	Belongs to the MraZ family
AA314_RS39210	COG1960	acyl-CoA dehydrogenase activity
AA314_RS39265	COG0174	glutamine synthetase
AA314_RS39270	COG1012	belongs to the aldehyde dehydrogenase family
AA314_RS39275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AA314_RS39275	COG0519	Catalyzes the synthesis of GMP from XMP
AA314_RS39285	COG0628	permease
AA314_RS39295	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AA314_RS39305	COG1254	Belongs to the acylphosphatase family
AA314_RS39320	COG1295	ribonuclease BN
AA314_RS39325	COG0776	regulation of translation
AA314_RS39335	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AA314_RS39345	COG1987	bacterial-type flagellum assembly
AA314_RS39350	COG4790	Type iii secretion
AA314_RS39370	COG4669	(LipO)protein
AA314_RS39390	COG0745	RESPONSE REGULATOR receiver
AA314_RS39395	COG0577	efflux transmembrane transporter activity
AA314_RS39435	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AA314_RS39470	COG1136	(ABC) transporter
AA314_RS39510	COG0714	Associated with various cellular activities
AA314_RS39530	COG3541	Predicted nucleotidyltransferase
AA314_RS39645	COG1215	transferase activity, transferring glycosyl groups
AA314_RS39650	COG0484	heat shock protein binding
AA314_RS39670	COG5507	3-demethylubiquinone-9 3-methyltransferase
AA314_RS39730	COG3279	Response regulator of the LytR AlgR family
AA314_RS39735	COG3275	phosphorelay sensor kinase activity
AA314_RS39740	COG0596	Alpha beta hydrolase
AA314_RS39750	COG0789	Transcriptional regulator
AA314_RS39755	COG2226	methyltransferase
AA314_RS39760	COG2124	cytochrome p450
AA314_RS39835	COG2239	Acts as a magnesium transporter
AA314_RS39855	COG1301	dicarboxylic acid transport
AA314_RS39880	COG0668	transmembrane transport
AA314_RS39895	COG1705	Flagellar rod assembly protein muramidase FlgJ
AA314_RS39895	COG1388	LysM domain
AA314_RS39940	COG0515	serine threonine protein kinase
AA314_RS39955	COG1136	(ABC) transporter
AA314_RS39955	COG0577	efflux transmembrane transporter activity
AA314_RS39985	COG0402	S-adenosylhomocysteine deaminase activity
AA314_RS40005	COG3845	ABC transporter
AA314_RS40010	COG4603	Belongs to the binding-protein-dependent transport system permease family
AA314_RS40015	COG1079	Belongs to the binding-protein-dependent transport system permease family
AA314_RS40030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA314_RS40040	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AA314_RS40090	COG0552	protein localization to endoplasmic reticulum
AA314_RS40120	COG1215	transferase activity, transferring glycosyl groups
AA314_RS40125	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA314_RS40135	COG2124	cytochrome p450
AA314_RS40185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA314_RS40200	COG0753	catalase activity
AA314_RS40240	COG0793	Belongs to the peptidase S41A family
AA314_RS40250	COG4942	peptidase
AA314_RS40255	COG2177	Part of the ABC transporter FtsEX involved in
AA314_RS40260	COG2884	Cell division ATP-binding protein ftsE
AA314_RS40275	COG0471	metal ion transport
AA314_RS40290	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AA314_RS40300	COG0811	peptide transport
AA314_RS40315	COG0823	Involved in the tonB-independent uptake of proteins
AA314_RS40345	COG0248	Ppx GppA phosphatase
AA314_RS40355	COG1902	pentaerythritol trinitrate reductase activity
AA314_RS40360	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AA314_RS40370	COG1024	Enoyl-CoA hydratase
AA314_RS40420	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA314_RS40430	COG3409	Peptidoglycan-binding domain 1 protein
AA314_RS40430	COG3267	Type II secretory pathway component ExeA
AA314_RS40440	COG0439	Biotin carboxylase
AA314_RS40445	COG0511	ligase activity, forming carbon-carbon bonds
AA314_RS40450	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AA314_RS40490	COG2204	response regulator
AA314_RS40495	COG4191	Histidine kinase
AA314_RS40500	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AA314_RS40505	COG4968	Prepilin-type N-terminal cleavage methylation domain
AA314_RS40515	COG1131	(ABC) transporter
AA314_RS40530	COG3852	Histidine kinase
AA314_RS40535	COG1459	type II secretion system
AA314_RS40545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AA314_RS40550	COG0196	riboflavin kinase activity
AA314_RS40555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AA314_RS40610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AA314_RS40620	COG0443	Heat shock 70 kDa protein
AA314_RS40630	COG1253	flavin adenine dinucleotide binding
AA314_RS40635	COG4191	Histidine kinase
AA314_RS40635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA314_RS40640	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AA314_RS40650	COG0793	Belongs to the peptidase S41A family
AA314_RS40660	COG0584	glycerophosphoryl diester phosphodiesterase
AA314_RS40665	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AA314_RS40695	COG1192	Involved in chromosome partitioning
AA314_RS40765	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AA314_RS40770	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AA314_RS40785	COG5002	protein histidine kinase activity
AA314_RS40790	COG5002	protein histidine kinase activity
AA314_RS40810	COG4191	Histidine kinase
AA314_RS40830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA314_RS40830	COG0784	Response regulator, receiver
AA314_RS40830	COG2198	Histidine kinase
AA314_RS40830	COG2205	protein histidine kinase activity
AA314_RS40835	COG4555	ABC transporter
AA314_RS40845	COG2766	serine protein kinase
AA314_RS40850	COG2718	Belongs to the UPF0229 family
AA314_RS40855	COG2719	SpoVR family
AA314_RS40860	COG0739	heme binding
AA314_RS40875	COG0058	SHG alpha-glucan phosphorylase activity
AA314_RS40890	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS40895	COG1024	Enoyl-CoA hydratase
AA314_RS40900	COG0587	DNA-directed DNA polymerase activity
AA314_RS40915	COG0667	Aldo Keto reductase
AA314_RS40925	COG0277	FAD linked oxidase domain protein
AA314_RS40930	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AA314_RS41000	COG0154	amidase activity
AA314_RS41030	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
AA314_RS41135	COG2264	protein methyltransferase activity
AA314_RS41140	COG0531	amino acid
AA314_RS41145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA314_RS41155	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AA314_RS41180	COG0326	Molecular chaperone. Has ATPase activity
AA314_RS41240	COG3157	Type VI secretion system effector, Hcp
AA314_RS41285	COG2032	superoxide dismutase activity
AA314_RS41290	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS41300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AA314_RS41305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AA314_RS41355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AA314_RS41370	COG3321	synthase
AA314_RS41370	COG0604	alcohol dehydrogenase
AA314_RS41370	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS41430	COG0667	Aldo Keto reductase
AA314_RS41510	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA314_RS41555	COG4941	Belongs to the sigma-70 factor family
AA314_RS41560	COG3620	sequence-specific DNA binding
AA314_RS41565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AA314_RS41570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AA314_RS41610	COG0183	Belongs to the thiolase family
AA314_RS41635	COG3118	belongs to the thioredoxin family
AA314_RS41650	COG0667	Aldo Keto reductase
AA314_RS41655	COG1012	belongs to the aldehyde dehydrogenase family
AA314_RS41665	COG0813	purine-nucleoside phosphorylase activity
AA314_RS41680	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA314_RS41700	COG2032	superoxide dismutase activity
AA314_RS41710	COG0805	protein transport
AA314_RS41710	COG0805	protein transport
AA314_RS41730	COG0123	including yeast histone deacetylase and acetoin utilization protein
AA314_RS41740	COG0625	glutathione transferase activity
AA314_RS41770	COG0300	oxidoreductase activity
AA314_RS41795	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AA314_RS41795	COG1793	dna ligase
AA314_RS41835	COG2086	electron transfer activity
AA314_RS41840	COG1960	acyl-CoA dehydrogenase activity
AA314_RS41845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AA314_RS41865	COG1595	DNA-templated transcription, initiation
AA314_RS41885	COG0564	pseudouridine synthase activity
AA314_RS41900	COG2124	cytochrome p450
AA314_RS41925	COG2124	cytochrome p450
AA314_RS41950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AA314_RS41955	COG0179	Fumarylacetoacetate (FAA) hydrolase
AA314_RS41960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AA314_RS41965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA314_RS41980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AA314_RS41985	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AA314_RS41995	COG0501	Belongs to the peptidase M48B family
AA314_RS42000	COG1295	ribonuclease BN
AA314_RS42010	COG0697	spore germination
AA314_RS42020	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AA314_RS42025	COG2096	Adenosyltransferase
AA314_RS42030	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AA314_RS42035	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AA314_RS42050	COG0784	Response regulator, receiver
AA314_RS42055	COG4251	negative regulation of phosphorylation
AA314_RS42060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA314_RS42065	COG1078	dGTPase activity
AA314_RS42070	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA314_RS42090	COG1331	Highly conserved protein containing a thioredoxin domain
AA314_RS42120	COG4974	Belongs to the 'phage' integrase family
AA314_RS42155	COG1695	Transcriptional regulator
AA314_RS42165	COG2326	polyphosphate kinase activity
AA314_RS42170	COG1196	nuclear chromosome segregation
AA314_RS42215	COG2311	Membrane
AA314_RS42230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AA314_RS42235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA314_RS42275	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA314_RS42275	COG0596	Alpha beta hydrolase
AA314_RS42285	COG0515	serine threonine protein kinase
AA314_RS42335	COG0037	tRNA processing
AA314_RS42340	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AA314_RS42375	COG0477	Major facilitator Superfamily
AA314_RS42390	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AA314_RS42405	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AA314_RS42415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_RS42435	COG1131	(ABC) transporter
AA314_RS42455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA314_RS42460	COG2197	response regulator
AA314_RS42470	COG4191	Histidine kinase
AA314_RS42490	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AA314_RS42510	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AA314_RS42525	COG2201	protein-glutamate methylesterase activity
AA314_RS42540	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AA314_RS42550	COG2197	response regulator
AA314_RS42555	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AA314_RS42565	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA314_RS42570	COG1278	Cold shock
AA314_RS42595	COG1472	Belongs to the glycosyl hydrolase 3 family
AA314_RS42610	COG2267	carboxylic ester hydrolase activity
AA314_RS42650	COG0657	acetylesterase activity
AA314_RS42665	COG0745	RESPONSE REGULATOR receiver
AA314_RS42670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AA314_RS42685	COG4771	TonB-dependent receptor
AA314_RS42695	COG2204	response regulator
AA314_RS42700	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AA314_RS42705	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AA314_RS42730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AA314_RS42735	COG0134	indole-3-glycerol-phosphate synthase activity
AA314_RS42740	COG0135	phosphoribosylanthranilate isomerase activity
AA314_RS42745	COG0133	tryptophan synthase activity
AA314_RS42750	COG0159	tryptophan synthase activity
AA314_RS42765	COG0406	alpha-ribazole phosphatase activity
AA314_RS42770	COG2124	cytochrome p450
AA314_RS42805	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AA314_RS42815	COG0693	protein deglycase activity
AA314_RS42835	COG0300	oxidoreductase activity
AA314_RS42850	COG0437	4 iron, 4 sulfur cluster binding
AA314_RS42885	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AA314_RS42890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA314_RS42975	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AA314_RS43015	COG0515	serine threonine protein kinase
AA314_RS43020	COG4191	Histidine kinase
AA314_RS43020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA314_RS43030	COG1764	response to oxidative stress
AA314_RS43035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA314_RS43040	COG1846	Transcriptional regulator
AA314_RS43090	COG1505	serine-type exopeptidase activity
AA314_RS43105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA314_RS43155	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AA314_RS43160	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AA314_RS43165	COG0469	pyruvate kinase activity
AA314_RS43225	COG5001	Diguanylate cyclase
AA314_RS43260	COG3179	chitinase
AA314_RS43280	COG2815	serine threonine protein kinase
AA314_RS43280	COG0515	serine threonine protein kinase
AA314_RS43315	COG0402	S-adenosylhomocysteine deaminase activity
AA314_RS43335	COG3394	polysaccharide catabolic process
AA314_RS43340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA314_RS43370	COG0067	glutamate synthase
AA314_RS43370	COG0069	glutamate synthase activity
AA314_RS43370	COG0070	glutamate synthase
AA314_RS43375	COG5002	protein histidine kinase activity
AA314_RS43380	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AA314_RS43390	COG0515	serine threonine protein kinase
AA314_RS43390	COG2815	serine threonine protein kinase
AA314_RS43395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA314_RS43400	COG0745	RESPONSE REGULATOR receiver
AA314_RS43410	COG5002	protein histidine kinase activity
AA314_RS43420	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AA314_RS43425	COG0248	Ppx GppA phosphatase
AA314_RS43440	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AA314_RS43445	COG0300	oxidoreductase activity
AA314_RS43460	COG3234	Protein of unknown function (DUF1175)
AA314_RS43465	COG2373	Large extracellular alpha-helical protein
AA314_RS43470	COG4676	Protein conserved in bacteria
AA314_RS43510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA314_RS43530	COG0473	3-isopropylmalate dehydrogenase activity
AA314_RS43540	COG0326	Molecular chaperone. Has ATPase activity
AA314_RS43545	COG0023	Translation Initiation Factor
AA314_RS43560	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA314_RS43570	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AA314_RS43575	COG0625	glutathione transferase activity
AA314_RS43605	COG0745	RESPONSE REGULATOR receiver
AA314_RS43610	COG5000	phosphorelay sensor kinase activity
AA314_RS43610	COG5002	protein histidine kinase activity
AA314_RS43615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA314_RS43620	COG1136	(ABC) transporter
AA314_RS43625	COG0577	efflux transmembrane transporter activity
AA314_RS43625	COG1136	(ABC) transporter
AA314_RS43645	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS43675	COG0515	serine threonine protein kinase
AA314_RS43720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AA314_RS43730	COG0277	FAD linked oxidase domain protein
AA314_RS43825	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AA314_RS43830	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AA314_RS43855	COG1131	(ABC) transporter
AA314_RS43875	COG0741	lytic transglycosylase activity
AA314_RS43895	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AA314_RS43895	COG3608	succinylglutamate desuccinylase aspartoacylase
AA314_RS43910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AA314_RS43915	COG0676	glucose-6-phosphate 1-epimerase activity
AA314_RS43930	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AA314_RS43975	COG4191	Histidine kinase
AA314_RS43980	COG5002	protein histidine kinase activity
AA314_RS44025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AA314_RS44045	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AA314_RS44050	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AA314_RS44055	COG0456	acetyltransferase
AA314_RS44065	COG0667	Aldo Keto reductase
AA314_RS44080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AA314_RS44095	COG4783	chaperone-mediated protein folding
AA314_RS44130	COG0443	Heat shock 70 kDa protein
AA314_RS44145	COG1022	Amp-dependent synthetase and ligase
AA314_RS44155	COG0681	Belongs to the peptidase S26 family
AA314_RS44170	COG0737	Belongs to the 5'-nucleotidase family
AA314_RS44185	COG0740	serine-type endopeptidase activity
AA314_RS44220	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AA314_RS44240	COG0114	fumarate hydratase activity
AA314_RS44265	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AA314_RS44270	COG2224	Isocitrate lyase
AA314_RS44275	COG4717	serine-type aminopeptidase activity
AA314_RS44280	COG0420	3'-5' exonuclease activity
AA314_RS44290	COG1819	glycosyl
AA314_RS44295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA314_RS44360	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AA314_RS44375	COG2094	Belongs to the DNA glycosylase MPG family
AA314_RS44380	COG1640	4-alpha-glucanotransferase
AA314_RS44390	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA314_RS44425	COG2124	cytochrome p450
AA314_RS44495	COG1131	(ABC) transporter
AA314_RS44505	COG0714	Associated with various cellular activities
AA314_RS44530	COG4771	TonB-dependent receptor
AA314_RS44540	COG0443	Heat shock 70 kDa protein
AA314_RS44650	COG2205	protein histidine kinase activity
AA314_RS44720	COG2885	chlorophyll binding
AA314_RS44725	COG1744	ABC transporter substrate-binding protein PnrA-like
AA314_RS44730	COG1940	carbohydrate kinase activity
AA314_RS44750	COG0515	serine threonine protein kinase
AA314_RS44825	COG2204	response regulator
AA314_RS44835	COG1968	undecaprenyl-diphosphatase activity
AA314_RS44840	COG3012	SEC-C Motif Domain Protein
AA314_RS44890	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AA314_RS44895	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AA314_RS44920	COG0076	glutamate decarboxylase activity
AA314_RS44930	COG0745	RESPONSE REGULATOR receiver
AA314_RS44965	COG1285	pathogenesis
AA314_RS44970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AA314_RS44980	COG3716	PTS system mannose fructose sorbose family IID component
AA314_RS44990	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AA314_RS44995	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AA314_RS44995	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AA314_RS45000	COG1660	Displays ATPase and GTPase activities
AA314_RS45005	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AA314_RS45015	COG0537	adenosine 5'-monophosphoramidase activity
AA314_RS45030	COG0038	chloride channel
AA314_RS45040	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AA314_RS45055	COG0723	plastoquinol--plastocyanin reductase activity
AA314_RS45115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA314_RS45120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AA314_RS45145	COG1596	polysaccharide export
AA314_RS45145	COG1555	photosystem II stabilization
AA314_RS45160	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AA314_RS45175	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AA314_RS45180	COG4208	sulfate ABC transporter
AA314_RS45185	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AA314_RS45190	COG2814	Major facilitator Superfamily
AA314_RS45205	COG1846	Transcriptional regulator
AA314_RS45225	COG2124	cytochrome p450
AA314_RS45235	COG3119	arylsulfatase activity
AA314_RS45250	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AA314_RS45255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AA314_RS45280	COG0784	Response regulator, receiver
AA314_RS45280	COG2205	protein histidine kinase activity
AA314_RS45280	COG5002	protein histidine kinase activity
AA314_RS45290	COG0443	Heat shock 70 kDa protein
AA314_RS45300	COG0714	Associated with various cellular activities
AA314_RS45315	COG0745	RESPONSE REGULATOR receiver
AA314_RS45330	COG1472	Belongs to the glycosyl hydrolase 3 family
AA314_RS45365	COG0745	RESPONSE REGULATOR receiver
AA314_RS45380	COG0546	phosphoglycolate phosphatase activity
AA314_RS45380	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AA314_RS45400	COG3424	synthase
AA314_RS45405	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_RS45450	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_RS45460	COG1755	Isoprenylcysteine carboxyl methyltransferase
AA314_RS45515	COG2204	response regulator
AA314_RS45585	COG2124	cytochrome p450
AA314_RS45590	COG3387	PFAM Glycoside hydrolase 15-related
AA314_RS45660	COG1215	transferase activity, transferring glycosyl groups
AA314_RS45675	COG4969	Belongs to the N-Me-Phe pilin family
AA314_RS45700	COG0442	prolyl-tRNA aminoacylation
AA314_RS45755	COG4106	trans-aconitate 2-methyltransferase activity
AA314_RS45790	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA314_RS45805	COG0515	serine threonine protein kinase
AA314_RS45810	COG0443	Heat shock 70 kDa protein
AA314_RS45815	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AA314_RS45865	COG4948	Mandelate Racemase Muconate Lactonizing
AA314_RS45890	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AA314_RS45895	COG1691	(AIR) carboxylase
AA314_RS45905	COG0366	Alpha amylase catalytic
AA314_RS45925	COG3833	ABC-type maltose transport systems, permease component
AA314_RS45940	COG3842	ATPase activity
AA314_RS45960	COG2198	Histidine kinase
AA314_RS45960	COG0643	Histidine kinase
AA314_RS45965	COG2201	protein-glutamate methylesterase activity
AA314_RS45970	COG0835	chemotaxis
AA314_RS45980	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AA314_RS45995	COG5002	protein histidine kinase activity
AA314_RS46000	COG1100	Small GTP-binding protein
AA314_RS46025	COG1199	ATP-dependent helicase activity
AA314_RS46045	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AA314_RS46075	COG0546	phosphoglycolate phosphatase activity
AA314_RS46095	COG1597	lipid kinase activity
AA314_RS46105	COG2267	carboxylic ester hydrolase activity
AA314_RS46120	COG1420	regulation of RNA biosynthetic process
AA314_RS46140	COG0697	spore germination
AA314_RS46185	COG2133	pyrroloquinoline quinone binding
AA314_RS46195	COG0025	NhaP-type Na H and K H
AA314_RS46200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_RS46225	COG4651	solute:proton antiporter activity
AA314_RS46225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA314_RS46270	COG1120	ATPase activity
AA314_RS46290	COG0408	coproporphyrinogen oxidase activity
AA314_RS46320	COG0577	efflux transmembrane transporter activity
AA314_RS46340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA314_RS46355	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AA314_RS46360	COG2154	pterin-4-alpha-carbinolamine dehydratase
AA314_RS46400	COG2264	protein methyltransferase activity
AA314_RS46405	COG2171	N-acyltransferase activity
AA314_RS46425	COG0076	glutamate decarboxylase activity
AA314_RS46435	COG1215	transferase activity, transferring glycosyl groups
AA314_RS46445	COG1077	Cell shape determining protein MreB Mrl
AA314_RS46455	COG1136	(ABC) transporter
AA314_RS46455	COG0577	efflux transmembrane transporter activity
AA314_RS46465	COG1136	(ABC) transporter
AA314_RS46530	COG0308	aminopeptidase N
AA314_RS46590	COG1132	(ABC) transporter
AA314_RS46595	COG1132	(ABC) transporter
AA314_RS46610	COG1668	transmembrane transport
AA314_RS46615	COG4555	ABC transporter
AA314_RS46630	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AA314_RS46650	COG2204	response regulator
AA314_RS46700	COG0546	phosphoglycolate phosphatase activity
AA314_RS46705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA314_RS46710	COG0545	Peptidyl-prolyl cis-trans isomerase
AA314_RS46730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AA314_RS46730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA314_RS46735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AA314_RS46755	COG0546	phosphoglycolate phosphatase activity
AA314_RS46780	COG3852	Histidine kinase
AA314_RS46795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA314_RS46840	COG2204	response regulator
AA314_RS46850	COG1160	GTP binding
AA314_RS46925	COG5002	protein histidine kinase activity
AA314_RS46945	COG2201	protein-glutamate methylesterase activity
AA314_RS46950	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AA314_RS46960	COG0835	chemotaxis
AA314_RS46965	COG0840	transmembrane signaling receptor activity
AA314_RS46970	COG0643	Histidine kinase
AA314_RS46970	COG2198	Histidine kinase
AA314_RS46975	COG0835	chemotaxis
AA314_RS46980	COG0840	transmembrane signaling receptor activity
AA314_RS46985	COG2204	response regulator
AA314_RS47015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AA314_RS47020	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS47035	COG0402	S-adenosylhomocysteine deaminase activity
AA314_RS47045	COG1505	serine-type exopeptidase activity
AA314_RS47100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA314_RS47110	COG0537	adenosine 5'-monophosphoramidase activity
AA314_RS47120	COG1022	Amp-dependent synthetase and ligase
AA314_RS47145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA314_RS47165	COG1271	oxidase subunit
AA314_RS47190	COG1959	2 iron, 2 sulfur cluster binding
AA314_RS47200	COG2346	COG2346, Truncated hemoglobins
AA314_RS47205	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AA314_RS47215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AA314_RS47220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AA314_RS47230	COG2949	membrane
AA314_RS47255	COG3118	belongs to the thioredoxin family
AA314_RS47265	COG0673	inositol 2-dehydrogenase activity
AA314_RS47310	COG0135	phosphoribosylanthranilate isomerase activity
AA314_RS47315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AA314_RS47330	COG2304	oxidoreductase activity
AA314_RS47350	COG0588	phosphoglycerate mutase activity
AA314_RS47385	COG2321	neutral zinc metallopeptidase
AA314_RS47395	COG0531	amino acid
AA314_RS47470	COG5002	protein histidine kinase activity
AA314_RS47475	COG0835	chemotaxis
AA314_RS47490	COG0840	transmembrane signaling receptor activity
AA314_RS47490	COG5278	phosphoserine phosphatase activity
AA314_RS47500	COG2201	protein-glutamate methylesterase activity
AA314_RS47505	COG5002	protein histidine kinase activity
AA314_RS47535	COG0835	chemotaxis
AA314_RS47540	COG0840	transmembrane signaling receptor activity
AA314_RS47545	COG0840	transmembrane signaling receptor activity
AA314_RS47560	COG0745	RESPONSE REGULATOR receiver
AA314_RS47570	COG1324	tolerance protein
AA314_RS47595	COG0542	response to heat
AA314_RS47650	COG5464	transposase or invertase
AA314_RS47665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA314_RS47665	COG2198	Histidine kinase
AA314_RS47665	COG0784	Response regulator, receiver
AA314_RS47665	COG2205	protein histidine kinase activity
AA314_RS47730	COG0534	Mate efflux family protein
AA314_RS47765	COG0443	Heat shock 70 kDa protein
AA314_RS47770	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AA314_RS47805	COG2198	Histidine kinase
AA314_RS47805	COG0784	Response regulator, receiver
AA314_RS47805	COG2205	protein histidine kinase activity
AA314_RS47810	COG2205	protein histidine kinase activity
AA314_RS47850	COG0596	Alpha beta hydrolase
AA314_RS47885	COG0653	protein targeting
AA314_RS47915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AA314_RS47955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_RS48005	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AA314_RS48205	COG0583	DNA-binding transcription factor activity
AA314_RS48220	COG1100	Small GTP-binding protein
AA314_RS48225	COG1960	acyl-CoA dehydrogenase activity
AA314_RS48250	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS48260	COG0583	DNA-binding transcription factor activity
AA314_RS48280	COG2764	glyoxalase bleomycin resistance protein dioxygenase
AA314_RS48285	COG0010	Belongs to the arginase family
AA314_RS48305	COG0412	Dienelactone hydrolase
AA314_RS48310	COG0545	Peptidyl-prolyl cis-trans isomerase
AA314_RS48370	COG3852	Histidine kinase
AA314_RS48375	COG0477	Major facilitator Superfamily
AA314_RS48445	COG1546	Belongs to the CinA family
AA314_RS48460	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_RS48465	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AA314_RS48475	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AA314_RS48490	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AA314_RS48510	COG1024	Enoyl-CoA hydratase
AA314_RS48525	COG1560	Kdo2-lipid A biosynthetic process
AA314_RS48540	COG3118	belongs to the thioredoxin family
AA314_RS48550	COG1446	asparaginase
AA314_RS48590	COG0515	serine threonine protein kinase
AA314_RS48590	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA314_RS48615	COG0589	response to stress
AA314_RS48635	COG5002	protein histidine kinase activity
AA314_RS48660	COG1051	belongs to the nudix hydrolase family
AA314_RS48660	COG1056	cytidyltransferase-related domain
AA314_RS48740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AA314_RS48835	COG2201	protein-glutamate methylesterase activity
AA314_RS48855	COG1858	cytochrome C peroxidase
AA314_RS48865	COG1268	BioY protein
AA314_RS48870	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AA314_RS48875	COG1122	ATPase activity
AA314_RS48880	COG1252	NADH dehydrogenase
AA314_RS48895	COG4191	Histidine kinase
AA314_RS48920	COG0625	glutathione transferase activity
AA314_RS48925	COG0154	amidase activity
AA314_RS48965	COG3591	Belongs to the peptidase S1B family
AA314_RS48990	COG3128	pkhd-type hydroxylase
AA314_RS49005	COG4774	siderophore transport
AA314_RS49015	COG3842	ATPase activity
AA314_RS49050	COG2204	response regulator
AA314_RS49055	COG2356	endonuclease I
AA314_RS49095	COG1653	transport
AA314_RS49100	COG2205	protein histidine kinase activity
AA314_RS49105	COG1278	Cold shock
AA314_RS49125	COG0745	RESPONSE REGULATOR receiver
AA314_RS49160	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA314_RS49160	COG1672	PFAM Archaeal ATPase
AA314_RS49200	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA314_RS49200	COG1672	PFAM Archaeal ATPase
AA314_RS49250	COG2814	Major facilitator Superfamily
AA314_RS49275	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_RS49275	COG2319	Wd-40 repeat
AA314_RS49420	COG0784	Response regulator, receiver
AA314_RS49420	COG2205	protein histidine kinase activity
AA314_RS49430	COG5635	Nacht domain
AA314_RS49430	COG2319	Wd-40 repeat
AA314_RS49435	COG2205	protein histidine kinase activity
AA314_RS49445	COG0517	IMP dehydrogenase activity
AA314_RS49465	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AA314_RS49480	COG4999	Histidine kinase
AA314_RS49480	COG3850	Histidine kinase
AA314_RS49480	COG2205	protein histidine kinase activity
AA314_RS49480	COG3437	response regulator, receiver
AA314_RS49485	COG1846	Transcriptional regulator
AA314_RS49520	COG0515	serine threonine protein kinase
AA314_RS49520	COG3064	Membrane
AA314_RS49520	COG4991	sh3 domain protein
AA314_RS49535	COG0666	response to abiotic stimulus
AA314_RS49555	COG3852	Histidine kinase
AA314_RS49585	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA314_RS49590	COG5002	protein histidine kinase activity
AA314_RS49595	COG5002	protein histidine kinase activity
AA314_RS49640	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA314_RS49675	COG2205	protein histidine kinase activity
AA314_RS49675	COG2202	Pas domain
AA314_RS49695	COG0515	serine threonine protein kinase
AA314_RS49725	COG2205	protein histidine kinase activity
AA314_RS49775	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AA314_RS49800	COG2205	protein histidine kinase activity
AA314_RS49800	COG0784	Response regulator, receiver
AA314_RS49840	COG4191	Histidine kinase
AA314_RS49850	COG5002	protein histidine kinase activity
AA314_RS49855	COG4251	negative regulation of phosphorylation
AA314_RS49860	COG4251	negative regulation of phosphorylation
AA314_RS49870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA314_RS49875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA314_RS49885	COG5002	protein histidine kinase activity
AA314_RS49920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA314_RS49925	COG0516	GMP reductase activity
AA314_RS49925	COG0517	IMP dehydrogenase activity
AA314_RS49945	COG2319	Wd-40 repeat
AA314_RS49945	COG5635	Nacht domain
AA314_RS50000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA314_RS50055	COG4191	Histidine kinase
AA314_RS50060	COG0745	RESPONSE REGULATOR receiver
AA314_RS50060	COG2205	protein histidine kinase activity
AA314_RS50060	COG3292	Two component regulator propeller
AA314_RS50090	COG1309	transcriptional regulator
AA314_RS50105	COG4251	negative regulation of phosphorylation
AA314_RS50110	COG2205	protein histidine kinase activity
AA314_RS50115	COG0840	transmembrane signaling receptor activity
AA314_RS50150	COG2339	peptidase activity
AA314_RS50155	COG1073	alpha beta
AA314_RS50165	COG1611	Belongs to the LOG family
AA314_RS50175	COG4191	Histidine kinase
AA314_RS50175	COG0784	Response regulator, receiver
AA314_RS50195	COG2202	Pas domain
AA314_RS50195	COG2205	protein histidine kinase activity
AA314_RS50200	COG0840	transmembrane signaling receptor activity
AA314_RS50240	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AA314_RS50245	COG5002	protein histidine kinase activity
AA314_RS50255	COG5183	chlorophyll binding
AA314_RS50255	COG2133	pyrroloquinoline quinone binding
AA314_RS50265	COG0784	Response regulator, receiver
AA314_RS50265	COG2205	protein histidine kinase activity
AA314_RS50275	COG2819	hydrolase of the alpha beta superfamily
AA314_RS50285	COG5002	protein histidine kinase activity
AA314_RS50315	COG0515	serine threonine protein kinase
AA314_RS50320	COG0438	transferase activity, transferring glycosyl groups
AA314_RS50325	COG0438	transferase activity, transferring glycosyl groups
AA314_RS50340	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AA314_RS50345	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AA314_RS50360	COG4191	Histidine kinase
AA314_RS50365	COG5002	protein histidine kinase activity
AA314_RS50380	COG0741	lytic transglycosylase activity
AA314_RS50380	COG1388	LysM domain
AA314_RS50385	COG0840	transmembrane signaling receptor activity
AA314_RS50390	COG1657	PFAM Prenyltransferase squalene oxidase
AA314_RS50410	COG0515	serine threonine protein kinase
AA314_RS50415	COG2319	Wd-40 repeat
AA314_RS50415	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_RS50435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA314_RS50435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA314_RS50440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA314_RS50520	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA314_RS50525	COG2234	aminopeptidase activity
AA314_RS50530	COG0642	Histidine kinase
AA314_RS50550	COG0515	serine threonine protein kinase
AA314_RS50585	COG5002	protein histidine kinase activity
AA314_RS50600	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA314_RS50605	COG5002	protein histidine kinase activity
AA314_RS50625	COG2202	Pas domain
AA314_RS50625	COG2205	protein histidine kinase activity
AA314_RS50635	COG5002	protein histidine kinase activity
AA314_RS50640	COG2205	protein histidine kinase activity
AA314_RS50640	COG0784	Response regulator, receiver
AA314_RS50660	COG5464	transposase or invertase
AA314_RS50685	COG0515	serine threonine protein kinase
AA314_RS50715	COG1028	Short-chain dehydrogenase reductase Sdr
AA314_RS50750	COG5002	protein histidine kinase activity
AA314_RS50760	COG5002	protein histidine kinase activity
AA314_RS50790	COG4251	negative regulation of phosphorylation
AA314_RS50800	COG2205	protein histidine kinase activity
AA314_RS50850	COG4191	Histidine kinase
AA314_RS50865	COG2815	serine threonine protein kinase
AA314_RS50865	COG0515	serine threonine protein kinase
AA314_RS50870	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AA314_RS50875	COG5002	protein histidine kinase activity
AA314_RS50875	COG2198	Histidine kinase
AA314_RS50875	COG0784	Response regulator, receiver
AA314_RS50905	COG0515	serine threonine protein kinase
AA314_RS50905	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA314_RS50940	COG2205	protein histidine kinase activity
AA314_RS51000	COG0791	NLP P60 protein
AA314_RS51075	COG5002	protein histidine kinase activity
AA314_RS51125	COG4191	Histidine kinase
AA314_RS51140	COG1309	transcriptional regulator
AA314_RS51190	COG0515	serine threonine protein kinase
AA314_RS51190	COG1357	PFAM Pentapeptide repeats (8 copies)
AA314_RS51195	COG0515	serine threonine protein kinase
AA314_RS51195	COG1357	PFAM Pentapeptide repeats (8 copies)
AA314_RS51255	COG0471	metal ion transport
AA314_RS51255	COG0490	domain, Protein
AA314_RS51270	COG0631	protein serine/threonine phosphatase activity
AA314_RS51315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA314_RS51370	COG2226	methyltransferase
AA314_RS51495	COG4249	Peptidase C14 caspase catalytic subunit p20
AA314_RS51495	COG2319	Wd-40 repeat
AA314_RS51510	COG5002	protein histidine kinase activity
AA314_RS51515	COG5002	protein histidine kinase activity
AA314_RS51515	COG3850	Histidine kinase
AA314_RS51520	COG0745	RESPONSE REGULATOR receiver
AA314_RS51530	COG0515	serine threonine protein kinase
AA314_RS51555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AA314_RS51620	COG0438	transferase activity, transferring glycosyl groups
AA314_RS51640	COG2385	sporulation resulting in formation of a cellular spore
AA314_RS51660	COG0438	transferase activity, transferring glycosyl groups
AA314_RS51715	COG0745	RESPONSE REGULATOR receiver
AA314_RS51740	COG4191	Histidine kinase
AA314_RS51745	COG2885	chlorophyll binding
AA314_RS51745	COG3047	cAMP biosynthetic process
AA314_RS51815	COG0318	PFAM AMP-dependent synthetase and ligase
AA314_RS51850	COG5002	protein histidine kinase activity
AA314_RS51855	COG1309	transcriptional regulator
AA314_RS51880	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AA314_RS51885	COG5002	protein histidine kinase activity
AA314_RS51895	COG4191	Histidine kinase
AA314_RS51895	COG2205	protein histidine kinase activity
AA314_RS51895	COG0745	RESPONSE REGULATOR receiver
AA314_RS51925	COG0653	protein targeting
AA314_RS51935	COG5002	protein histidine kinase activity