locus-tag	class	description
AAQM_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AAQM_RS00010	COG0592	DNA-directed DNA polymerase activity
AAQM_RS00015	COG0187	DNA topoisomerase II activity
AAQM_RS00020	COG0492	ferredoxin-NADP+ reductase activity
AAQM_RS00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AAQM_RS00035	COG1238	metal cluster binding
AAQM_RS00045	COG0564	pseudouridine synthase activity
AAQM_RS00050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AAQM_RS00055	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AAQM_RS00060	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AAQM_RS00090	COG2954	triphosphatase activity
AAQM_RS00095	COG1151	hydroxylamine reductase activity
AAQM_RS00105	COG0493	'glutamate synthase
AAQM_RS00110	COG3047	cAMP biosynthetic process
AAQM_RS00110	COG2885	chlorophyll binding
AAQM_RS00115	COG0052	Belongs to the universal ribosomal protein uS2 family
AAQM_RS00120	COG0604	alcohol dehydrogenase
AAQM_RS00125	COG1733	regulation of RNA biosynthetic process
AAQM_RS00135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AAQM_RS00140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AAQM_RS00155	COG0745	RESPONSE REGULATOR receiver
AAQM_RS00160	COG4191	Histidine kinase
AAQM_RS00165	COG1556	Lactate utilization protein
AAQM_RS00170	COG1139	Iron-sulfur cluster binding protein
AAQM_RS00175	COG0247	lactate metabolic process
AAQM_RS00185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AAQM_RS00185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AAQM_RS00190	COG0511	ligase activity, forming carbon-carbon bonds
AAQM_RS00195	COG0439	Biotin carboxylase
AAQM_RS00200	COG0513	Belongs to the DEAD box helicase family
AAQM_RS00205	COG0306	phosphate transporter
AAQM_RS00215	COG0367	asparagine synthase
AAQM_RS00225	COG0778	Nitroreductase
AAQM_RS00235	COG1053	succinate dehydrogenase
AAQM_RS00245	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AAQM_RS00255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AAQM_RS00255	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AAQM_RS00260	COG1187	pseudouridine synthase activity
AAQM_RS00265	COG0517	IMP dehydrogenase activity
AAQM_RS00265	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AAQM_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AAQM_RS00280	COG0107	imidazoleglycerol-phosphate synthase activity
AAQM_RS00295	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AAQM_RS00300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AAQM_RS00305	COG0724	RNA recognition motif
AAQM_RS00310	COG0745	RESPONSE REGULATOR receiver
AAQM_RS00315	COG0642	Histidine kinase
AAQM_RS00335	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AAQM_RS00340	COG2353	YceI-like domain
AAQM_RS00350	COG0534	Mate efflux family protein
AAQM_RS00355	COG0460	homoserine dehydrogenase
AAQM_RS00360	COG0436	Aminotransferase
AAQM_RS00375	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AAQM_RS00380	COG0254	rRNA binding
AAQM_RS00385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AAQM_RS00415	COG0582	viral genome integration into host DNA
AAQM_RS00495	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AAQM_RS00505	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AAQM_RS00510	COG0237	dephospho-CoA kinase activity
AAQM_RS00515	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AAQM_RS00520	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AAQM_RS00525	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AAQM_RS00530	COG1741	Belongs to the pirin family
AAQM_RS00535	COG3384	dioxygenase
AAQM_RS00545	COG1846	Transcriptional regulator
AAQM_RS00550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AAQM_RS00555	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AAQM_RS00560	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AAQM_RS00570	COG0505	Belongs to the CarA family
AAQM_RS00590	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AAQM_RS00590	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AAQM_RS00605	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AAQM_RS00610	COG0489	protein tyrosine kinase activity
AAQM_RS00620	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AAQM_RS00620	COG0140	phosphoribosyl-ATP diphosphatase activity
AAQM_RS00645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AAQM_RS00655	COG0646	methionine synthase
AAQM_RS00655	COG1410	methionine synthase
AAQM_RS00660	COG0450	alkyl hydroperoxide reductase
AAQM_RS00675	COG1979	alcohol dehydrogenase
AAQM_RS00680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AAQM_RS00680	COG2205	protein histidine kinase activity
AAQM_RS00690	COG1686	Belongs to the peptidase S11 family
AAQM_RS00705	COG1854	S-ribosylhomocysteine lyase activity
AAQM_RS00730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AAQM_RS00735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AAQM_RS00750	COG3180	Ammonia monooxygenase
AAQM_RS00755	COG1733	regulation of RNA biosynthetic process
AAQM_RS00760	COG2249	NAD(P)H dehydrogenase (quinone) activity
AAQM_RS00765	COG1013	pyruvate-flavodoxin oxidoreductase activity
AAQM_RS00770	COG0674	pyruvate-flavodoxin oxidoreductase activity
AAQM_RS00780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AAQM_RS00785	COG0546	phosphoglycolate phosphatase activity
AAQM_RS00795	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AAQM_RS00800	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AAQM_RS00805	COG2205	protein histidine kinase activity
AAQM_RS00810	COG0745	RESPONSE REGULATOR receiver
AAQM_RS00820	COG0704	Plays a role in the regulation of phosphate uptake
AAQM_RS00825	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AAQM_RS00830	COG0581	inorganic phosphate transmembrane transporter activity
AAQM_RS00835	COG0573	inorganic phosphate transmembrane transporter activity
AAQM_RS00840	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AAQM_RS00850	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AAQM_RS00855	COG0268	Binds directly to 16S ribosomal RNA
AAQM_RS00860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AAQM_RS00865	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AAQM_RS00870	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AAQM_RS00875	COG0746	molybdenum cofactor guanylyltransferase activity
AAQM_RS00880	COG0446	pyridine nucleotide-disulphide oxidoreductase
AAQM_RS00895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AAQM_RS00900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AAQM_RS00905	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AAQM_RS00945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AAQM_RS00965	COG3321	synthase
AAQM_RS00965	COG4221	oxidoreductase activity
AAQM_RS00965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AAQM_RS00965	COG1028	Short-chain dehydrogenase reductase Sdr
AAQM_RS00970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AAQM_RS00980	COG1131	(ABC) transporter
AAQM_RS01005	COG1028	Short-chain dehydrogenase reductase Sdr
AAQM_RS01010	COG2986	histidine ammonia-lyase
AAQM_RS01035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AAQM_RS01040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AAQM_RS01065	COG0575	Belongs to the CDS family
AAQM_RS01070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AAQM_RS01090	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AAQM_RS01100	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AAQM_RS01100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AAQM_RS01105	COG1324	tolerance protein
AAQM_RS01110	COG2022	thiamine diphosphate biosynthetic process
AAQM_RS01150	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AAQM_RS01155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AAQM_RS01175	COG0840	transmembrane signaling receptor activity
AAQM_RS01195	COG0745	RESPONSE REGULATOR receiver
AAQM_RS01220	COG4191	Histidine kinase
AAQM_RS01225	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AAQM_RS01245	COG1346	cytolysis
AAQM_RS01275	COG0659	secondary active sulfate transmembrane transporter activity
AAQM_RS01290	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AAQM_RS01300	COG3290	protein histidine kinase activity
AAQM_RS01315	COG0004	ammonium transporteR
AAQM_RS01320	COG0347	Belongs to the P(II) protein family
AAQM_RS01325	COG0004	ammonium transporteR
AAQM_RS01335	COG0418	dihydroorotase activity
AAQM_RS01345	COG1706	bacterial-type flagellum-dependent cell motility
AAQM_RS01380	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AAQM_RS01385	COG1256	bacterial-type flagellum assembly
AAQM_RS01385	COG4786	Flagellar basal body rod
AAQM_RS01390	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AAQM_RS01410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AAQM_RS01415	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AAQM_RS01420	COG0601	transmembrane transport
AAQM_RS01425	COG0736	holo-[acyl-carrier-protein] synthase activity
AAQM_RS01430	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AAQM_RS01440	COG0560	Phosphoserine phosphatase
AAQM_RS01445	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AAQM_RS01450	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AAQM_RS01455	COG3248	Nucleoside-binding outer membrane protein
AAQM_RS01460	COG1393	Belongs to the ArsC family
AAQM_RS01465	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AAQM_RS01470	COG0343	queuine tRNA-ribosyltransferase activity
AAQM_RS01480	COG0436	Aminotransferase
AAQM_RS01500	COG2861	carbohydrate metabolic process
AAQM_RS01505	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AAQM_RS01510	COG0557	exoribonuclease II activity
AAQM_RS01515	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AAQM_RS01525	COG0360	Binds together with S18 to 16S ribosomal RNA
AAQM_RS01530	COG0629	single-stranded DNA binding
AAQM_RS01535	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AAQM_RS01545	COG0215	cysteine-tRNA ligase activity
AAQM_RS01550	COG0195	Participates in both transcription termination and antitermination
AAQM_RS01560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AAQM_RS01565	COG2121	Domain of unknown function (DUF374)
AAQM_RS01575	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AAQM_RS01585	COG0288	reversible hydration of carbon dioxide
AAQM_RS01590	COG0156	8-amino-7-oxononanoate synthase activity
AAQM_RS01595	COG0792	nuclease activity
AAQM_RS01610	COG2885	chlorophyll binding
AAQM_RS01615	COG0469	pyruvate kinase activity
AAQM_RS01625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AAQM_RS01635	COG0540	Belongs to the ATCase OTCase family
AAQM_RS01640	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AAQM_RS01645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AAQM_RS01660	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AAQM_RS01665	COG1687	branched-chain amino acid
AAQM_RS01670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AAQM_RS01675	COG0416	fatty acid biosynthetic process
AAQM_RS01680	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AAQM_RS01690	COG0105	UTP biosynthetic process
AAQM_RS01700	COG0450	alkyl hydroperoxide reductase
AAQM_RS01705	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AAQM_RS01710	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AAQM_RS01715	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AAQM_RS01720	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AAQM_RS01730	COG0181	hydroxymethylbilane synthase activity
AAQM_RS01745	COG2828	Protein conserved in bacteria
AAQM_RS01750	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AAQM_RS01760	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AAQM_RS01770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AAQM_RS01795	COG0514	ATP-dependent DNA helicase (RecQ)
AAQM_RS01800	COG0500	methyltransferase
AAQM_RS01815	COG1451	nucleotide metabolic process
AAQM_RS01840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AAQM_RS01845	COG1053	succinate dehydrogenase
AAQM_RS01855	COG1007	ATP synthesis coupled electron transport
AAQM_RS01865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AAQM_RS01870	COG0713	ATP synthesis coupled electron transport
AAQM_RS01875	COG0839	Belongs to the complex I subunit 6 family
AAQM_RS01880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAQM_RS01885	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AAQM_RS01890	COG1034	ATP synthesis coupled electron transport
AAQM_RS01895	COG0372	Belongs to the citrate synthase family
AAQM_RS01910	COG0649	NAD binding
AAQM_RS01910	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAQM_RS01915	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAQM_RS01920	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAQM_RS01925	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AAQM_RS01930	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AAQM_RS01935	COG3610	response to peptide
AAQM_RS01940	COG2966	Psort location CytoplasmicMembrane, score
AAQM_RS01950	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AAQM_RS01955	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AAQM_RS01965	COG0840	transmembrane signaling receptor activity
AAQM_RS01990	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AAQM_RS02005	COG0840	transmembrane signaling receptor activity
AAQM_RS02025	COG3043	anaerobic respiration
AAQM_RS02030	COG0348	domain, Protein
AAQM_RS02035	COG0437	4 iron, 4 sulfur cluster binding
AAQM_RS02040	COG0243	molybdopterin cofactor binding
AAQM_RS02065	COG2204	response regulator
AAQM_RS02070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AAQM_RS02075	COG1648	precorrin-2 dehydrogenase activity
AAQM_RS02075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AAQM_RS02090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AAQM_RS02095	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AAQM_RS02110	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AAQM_RS02115	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AAQM_RS02120	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AAQM_RS02125	COG1959	2 iron, 2 sulfur cluster binding
AAQM_RS02130	COG2404	hydrolase activity, acting on ester bonds
AAQM_RS02140	COG0642	Histidine kinase
AAQM_RS02145	COG0745	RESPONSE REGULATOR receiver
AAQM_RS02155	COG0191	fructose-bisphosphate aldolase activity
AAQM_RS02160	COG3842	ATPase activity
AAQM_RS02170	COG1177	transmembrane transport
AAQM_RS02175	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AAQM_RS02200	COG1278	Cold shock
AAQM_RS02210	COG0811	peptide transport
AAQM_RS02220	COG4191	Histidine kinase
AAQM_RS02235	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AAQM_RS02245	COG0142	geranyltranstransferase activity
AAQM_RS02250	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AAQM_RS02255	COG0442	prolyl-tRNA aminoacylation
AAQM_RS02260	COG0668	transmembrane transport
AAQM_RS02265	COG0617	tRNA 3'-terminal CCA addition
AAQM_RS02280	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AAQM_RS02285	COG1862	Preprotein translocase
AAQM_RS02290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AAQM_RS02295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AAQM_RS02305	COG0495	leucyl-tRNA aminoacylation
AAQM_RS02315	COG0285	dihydrofolate synthase activity
AAQM_RS02355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AAQM_RS02365	COG3706	GGDEF domain
AAQM_RS02365	COG5001	Diguanylate cyclase
AAQM_RS02365	COG4251	negative regulation of phosphorylation
AAQM_RS02365	COG2203	Gaf domain
AAQM_RS02375	COG0745	RESPONSE REGULATOR receiver
AAQM_RS02380	COG0642	Histidine kinase
AAQM_RS02385	COG2081	HI0933 family
AAQM_RS02390	COG0840	transmembrane signaling receptor activity
AAQM_RS02400	COG3920	Histidine kinase
AAQM_RS02405	COG5000	phosphorelay sensor kinase activity
AAQM_RS02410	COG1692	metallophosphoesterase
AAQM_RS02425	COG2226	methyltransferase
AAQM_RS02430	COG1570	exodeoxyribonuclease VII activity
AAQM_RS02435	COG0835	chemotaxis
AAQM_RS02445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AAQM_RS02455	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AAQM_RS02460	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AAQM_RS02475	COG0459	protein refolding
AAQM_RS02480	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AAQM_RS02495	COG1408	metallophosphoesterase
AAQM_RS02520	COG1136	(ABC) transporter
AAQM_RS02520	COG0577	efflux transmembrane transporter activity
AAQM_RS02525	COG0577	efflux transmembrane transporter activity
AAQM_RS02525	COG1136	(ABC) transporter
AAQM_RS02535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AAQM_RS02550	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AAQM_RS02555	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AAQM_RS02560	COG0352	thiamine-phosphate diphosphorylase activity
AAQM_RS02565	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AAQM_RS02575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AAQM_RS02580	COG2264	protein methyltransferase activity
AAQM_RS02585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AAQM_RS02590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AAQM_RS02605	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AAQM_RS02610	COG3706	GGDEF domain
AAQM_RS02615	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AAQM_RS02620	COG1090	epimerase
AAQM_RS02625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AAQM_RS02640	COG0481	GTPase activity
AAQM_RS02655	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AAQM_RS02665	COG0482	sulfurtransferase activity
AAQM_RS02670	COG0482	sulfurtransferase activity
AAQM_RS02675	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AAQM_RS02680	COG0006	proline dipeptidase activity
AAQM_RS02685	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AAQM_RS02690	COG0402	S-adenosylhomocysteine deaminase activity
AAQM_RS02695	COG0616	signal peptide processing
AAQM_RS02705	COG0280	phosphate acetyltransferase
AAQM_RS02710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AAQM_RS02720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AAQM_RS02740	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AAQM_RS02750	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AAQM_RS02760	COG0745	RESPONSE REGULATOR receiver
AAQM_RS02765	COG5002	protein histidine kinase activity
AAQM_RS02810	COG1058	Belongs to the CinA family
AAQM_RS02810	COG1546	Belongs to the CinA family
AAQM_RS02815	COG0579	oxidoreductase
AAQM_RS02820	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AAQM_RS02835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AAQM_RS02860	COG0714	Associated with various cellular activities
AAQM_RS02865	COG0052	Belongs to the universal ribosomal protein uS2 family
AAQM_RS02870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AAQM_RS02875	COG1136	(ABC) transporter
AAQM_RS02885	COG0194	GDP metabolic process
AAQM_RS02890	COG5002	protein histidine kinase activity
AAQM_RS02890	COG5001	Diguanylate cyclase
AAQM_RS02895	COG2217	Heavy metal translocating P-type atpase
AAQM_RS02910	COG4608	Belongs to the ABC transporter superfamily
AAQM_RS02915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AAQM_RS02920	COG2078	PFAM AMMECR1 domain protein
AAQM_RS02925	COG1355	regulation of microtubule-based process
AAQM_RS02930	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AAQM_RS02935	COG1121	(ABC) transporter
AAQM_RS02940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AAQM_RS02945	COG1283	sodium-dependent phosphate transmembrane transporter activity
AAQM_RS02970	COG2996	Protein conserved in bacteria
AAQM_RS02975	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AAQM_RS02990	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AAQM_RS02995	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AAQM_RS03000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AAQM_RS03015	COG0582	viral genome integration into host DNA
AAQM_RS03045	COG0210	DNA helicase
AAQM_RS03050	COG0569	domain protein
AAQM_RS03050	COG0475	glutathione-regulated potassium exporter activity
AAQM_RS03055	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AAQM_RS03080	COG3258	Cytochrome c
AAQM_RS03130	COG0525	valine-tRNA ligase activity
AAQM_RS03140	COG0454	-acetyltransferase
AAQM_RS03150	COG4895	conserved protein (DUF2196)
AAQM_RS03155	COG1047	Peptidyl-prolyl cis-trans
AAQM_RS03165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AAQM_RS03175	COG1917	Cupin 2, conserved barrel domain protein
AAQM_RS03180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AAQM_RS03195	COG0739	heme binding
AAQM_RS03205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AAQM_RS03210	COG0138	bifunctional purine biosynthesis protein purh
AAQM_RS03235	COG0179	Fumarylacetoacetate (FAA) hydrolase
AAQM_RS03240	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AAQM_RS03245	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AAQM_RS03260	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AAQM_RS03275	COG0542	response to heat
AAQM_RS03280	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AAQM_RS03285	COG0594	ribonuclease P activity
AAQM_RS03290	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AAQM_RS03295	COG0706	membrane insertase activity
AAQM_RS03305	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AAQM_RS03320	COG0501	Belongs to the peptidase M48B family
AAQM_RS03325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AAQM_RS03330	COG0571	ribonuclease III activity
AAQM_RS03340	COG0358	DNA primase activity
AAQM_RS03350	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AAQM_RS03355	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AAQM_RS03360	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AAQM_RS03365	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AAQM_RS03370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AAQM_RS03380	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AAQM_RS03380	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AAQM_RS03385	COG1192	Involved in chromosome partitioning
AAQM_RS03390	COG1475	DNA binding
AAQM_RS03400	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AAQM_RS03405	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AAQM_RS03410	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AAQM_RS03415	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AAQM_RS03420	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AAQM_RS03425	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AAQM_RS03430	COG0811	peptide transport
AAQM_RS03435	COG0848	biopolymer transport protein
AAQM_RS03445	COG0823	Involved in the tonB-independent uptake of proteins
AAQM_RS03450	COG2193	ferroxidase activity
AAQM_RS03465	COG1047	Peptidyl-prolyl cis-trans
AAQM_RS03470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AAQM_RS03475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AAQM_RS03480	COG1115	amino acid carrier protein
AAQM_RS03490	COG0745	RESPONSE REGULATOR receiver
AAQM_RS03495	COG1027	Aspartate ammonia-lyase
AAQM_RS03510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AAQM_RS03515	COG0519	Catalyzes the synthesis of GMP from XMP
AAQM_RS03525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AAQM_RS03530	COG0010	Belongs to the arginase family
AAQM_RS03545	COG4773	Receptor
AAQM_RS03550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AAQM_RS03565	COG4335	DNA alkylation repair
AAQM_RS03590	COG5001	Diguanylate cyclase
AAQM_RS03590	COG5002	protein histidine kinase activity
AAQM_RS03605	COG2995	paraquat-inducible protein a
AAQM_RS03610	COG3008	intermembrane lipid transfer
AAQM_RS03620	COG3437	response regulator, receiver
AAQM_RS03625	COG4999	Histidine kinase
AAQM_RS03625	COG3437	response regulator, receiver
AAQM_RS03625	COG2205	protein histidine kinase activity
AAQM_RS03625	COG3850	Histidine kinase
AAQM_RS03635	COG3920	Histidine kinase
AAQM_RS03650	COG3111	PFAM Bacterial OB fold (BOF) protein
AAQM_RS03655	COG0642	Histidine kinase
AAQM_RS03660	COG0745	RESPONSE REGULATOR receiver
AAQM_RS03670	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AAQM_RS03675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AAQM_RS03680	COG0326	Molecular chaperone. Has ATPase activity
AAQM_RS03710	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AAQM_RS03720	COG1984	allophanate hydrolase subunit 2
AAQM_RS03745	COG0513	Belongs to the DEAD box helicase family
AAQM_RS03755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AAQM_RS03765	COG0259	pyridoxamine-phosphate oxidase activity
AAQM_RS03770	COG1078	dGTPase activity
AAQM_RS03775	COG0720	synthase
AAQM_RS03780	COG0418	dihydroorotase activity
AAQM_RS03785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AAQM_RS03785	COG0140	phosphoribosyl-ATP diphosphatase activity
AAQM_RS03790	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AAQM_RS03825	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AAQM_RS03825	COG1918	ferrous iron import across plasma membrane
AAQM_RS03830	COG1918	ferrous iron import across plasma membrane
AAQM_RS03855	COG4771	TonB-dependent receptor
AAQM_RS03865	COG0784	Response regulator, receiver
AAQM_RS03870	COG1538	Outer membrane efflux protein
AAQM_RS03875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AAQM_RS03885	COG0500	methyltransferase
AAQM_RS03890	COG4771	TonB-dependent receptor
AAQM_RS03910	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AAQM_RS03915	COG0585	pseudouridine synthase activity
AAQM_RS03925	COG0840	transmembrane signaling receptor activity
AAQM_RS03930	COG0632	four-way junction helicase activity
AAQM_RS03935	COG1181	Belongs to the D-alanine--D-alanine ligase family
AAQM_RS03940	COG2267	carboxylic ester hydrolase activity
AAQM_RS03945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AAQM_RS03960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AAQM_RS03965	COG0051	transcription antitermination factor activity, RNA binding
AAQM_RS03970	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AAQM_RS03975	COG0088	Forms part of the polypeptide exit tunnel
AAQM_RS03980	COG0089	rRNA binding
AAQM_RS03985	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AAQM_RS03990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AAQM_RS03995	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AAQM_RS04000	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AAQM_RS04005	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AAQM_RS04010	COG0255	Belongs to the universal ribosomal protein uL29 family
AAQM_RS04015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AAQM_RS04020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AAQM_RS04025	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AAQM_RS04030	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AAQM_RS04035	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AAQM_RS04040	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AAQM_RS04045	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AAQM_RS04050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AAQM_RS04055	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AAQM_RS04060	COG0200	Binds to the 23S rRNA
AAQM_RS04065	COG0201	protein transport
AAQM_RS04070	COG0024	Methionine aminopeptidase
AAQM_RS04075	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AAQM_RS04085	COG1573	uracil-dna glycosylase
AAQM_RS04095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AAQM_RS04110	COG1032	radical SAM domain protein
AAQM_RS04115	COG1280	lysine exporter protein (LysE YggA)
AAQM_RS04125	COG0563	adenylate kinase activity
AAQM_RS04145	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AAQM_RS04150	COG0322	excinuclease ABC activity
AAQM_RS04155	COG3706	GGDEF domain
AAQM_RS04165	COG3201	nicotinamide mononucleotide transporter
AAQM_RS04170	COG0386	Belongs to the glutathione peroxidase family
AAQM_RS04180	COG0840	transmembrane signaling receptor activity
AAQM_RS04185	COG0840	transmembrane signaling receptor activity
AAQM_RS04190	COG0726	polysaccharide deacetylase
AAQM_RS04230	COG3706	GGDEF domain
AAQM_RS04235	COG0708	Exodeoxyribonuclease III
AAQM_RS04265	COG0166	Belongs to the GPI family
AAQM_RS04310	COG3123	guanosine phosphorylase activity
AAQM_RS04330	COG0012	GTP binding
AAQM_RS04335	COG2252	PERMEase
AAQM_RS04340	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AAQM_RS04345	COG2363	Small membrane protein
AAQM_RS04355	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AAQM_RS04360	COG2233	PERMEase
AAQM_RS04365	COG1666	GTP binding
AAQM_RS04375	COG0745	RESPONSE REGULATOR receiver
AAQM_RS04380	COG0642	Histidine kinase
AAQM_RS04400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AAQM_RS04405	COG0135	phosphoribosylanthranilate isomerase activity
AAQM_RS04410	COG2176	DNA-directed DNA polymerase activity
AAQM_RS04415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AAQM_RS04425	COG1013	pyruvate-flavodoxin oxidoreductase activity
AAQM_RS04430	COG0674	pyruvate-flavodoxin oxidoreductase activity
AAQM_RS04430	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AAQM_RS04440	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AAQM_RS04445	COG0727	PFAM Uncharacterised protein family (UPF0153)
AAQM_RS04455	COG0134	indole-3-glycerol-phosphate synthase activity
AAQM_RS04460	COG0583	DNA-binding transcription factor activity
AAQM_RS04465	COG1942	4-Oxalocrotonate Tautomerase
AAQM_RS04470	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AAQM_RS04475	COG0750	zinc metalloprotease
AAQM_RS04480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AAQM_RS04485	COG1028	Short-chain dehydrogenase reductase Sdr
AAQM_RS04490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AAQM_RS04505	COG0167	dihydroorotate dehydrogenase activity
AAQM_RS04510	COG1132	(ABC) transporter
AAQM_RS04515	COG0728	peptidoglycan biosynthetic process
AAQM_RS04525	COG1592	Rubrerythrin
AAQM_RS04535	COG0530	calcium, potassium:sodium antiporter activity
AAQM_RS04540	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AAQM_RS04550	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AAQM_RS04585	COG1858	cytochrome C peroxidase
AAQM_RS04600	COG0552	protein localization to endoplasmic reticulum
AAQM_RS04605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AAQM_RS04615	COG1418	mRNA catabolic process
AAQM_RS04620	COG0742	ribosomal rna small subunit methyltransferase
AAQM_RS04625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AAQM_RS04635	COG0300	oxidoreductase activity
AAQM_RS04650	COG3258	Cytochrome c
AAQM_RS04665	COG0642	Histidine kinase
AAQM_RS04675	COG0157	Belongs to the NadC ModD family
AAQM_RS04685	COG1610	YqeY-like protein
AAQM_RS04695	COG0840	transmembrane signaling receptor activity
AAQM_RS04700	COG0840	transmembrane signaling receptor activity
AAQM_RS04720	COG0745	RESPONSE REGULATOR receiver
AAQM_RS04765	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AAQM_RS04770	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AAQM_RS04775	COG0436	Aminotransferase
AAQM_RS04795	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AAQM_RS04800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AAQM_RS04800	COG0519	Catalyzes the synthesis of GMP from XMP
AAQM_RS04815	COG2336	PFAM SpoVT AbrB
AAQM_RS04825	COG0473	3-isopropylmalate dehydrogenase activity
AAQM_RS04830	COG1028	Short-chain dehydrogenase reductase Sdr
AAQM_RS04835	COG2204	response regulator
AAQM_RS04875	COG0730	response to heat
AAQM_RS04880	COG0633	Ferredoxin
AAQM_RS04880	COG0543	2 iron, 2 sulfur cluster binding
AAQM_RS04905	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AAQM_RS04925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AAQM_RS04930	COG2267	carboxylic ester hydrolase activity
AAQM_RS04935	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AAQM_RS04950	COG0077	Prephenate dehydratase
AAQM_RS04950	COG1605	Chorismate mutase
AAQM_RS04955	COG2205	protein histidine kinase activity
AAQM_RS04990	COG0114	fumarate hydratase activity
AAQM_RS05025	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AAQM_RS05035	COG1643	Atp-dependent helicase
AAQM_RS05050	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AAQM_RS05070	COG0251	oxidation-reduction process
AAQM_RS05095	COG0596	Alpha beta hydrolase
AAQM_RS05100	COG1489	DNA binding
AAQM_RS05115	COG1696	Membrane protein involved in D-alanine export
AAQM_RS05120	COG0564	pseudouridine synthase activity
AAQM_RS05125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AAQM_RS05135	COG2223	nitrite transmembrane transporter activity
AAQM_RS05155	COG0300	oxidoreductase activity
AAQM_RS05160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AAQM_RS05160	COG0519	Catalyzes the synthesis of GMP from XMP
AAQM_RS05205	COG2815	serine threonine protein kinase
AAQM_RS05205	COG0515	serine threonine protein kinase
AAQM_RS05220	COG1253	flavin adenine dinucleotide binding
AAQM_RS05225	COG2989	Protein conserved in bacteria
AAQM_RS05230	COG0628	permease
AAQM_RS05245	COG4536	flavin adenine dinucleotide binding
AAQM_RS05260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AAQM_RS05270	COG1309	transcriptional regulator
AAQM_RS05285	COG0513	Belongs to the DEAD box helicase family
AAQM_RS05295	COG1045	serine acetyltransferase
AAQM_RS05300	COG1166	arginine decarboxylase activity
AAQM_RS05305	COG0124	histidyl-tRNA synthetase
AAQM_RS05310	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AAQM_RS05315	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AAQM_RS05320	COG0163	prenyltransferase activity
AAQM_RS05330	COG0359	binds to the 23S rRNA
AAQM_RS05335	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AAQM_RS05340	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AAQM_RS05350	COG0084	hydrolase, TatD family'
AAQM_RS05360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AAQM_RS05365	COG0131	Imidazoleglycerol-phosphate dehydratase
AAQM_RS05370	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AAQM_RS05385	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AAQM_RS05390	COG0456	acetyltransferase
AAQM_RS05395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AAQM_RS05400	COG3576	pyridoxamine 5-phosphate
AAQM_RS05430	COG1338	Plays a role in the flagellum-specific transport system
AAQM_RS05485	COG0849	cell division
AAQM_RS05490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AAQM_RS05505	COG0408	coproporphyrinogen oxidase activity
AAQM_RS05515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AAQM_RS05525	COG1193	negative regulation of DNA recombination
AAQM_RS05545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AAQM_RS05555	COG1119	ATPase activity
AAQM_RS05570	COG0077	Prephenate dehydratase
AAQM_RS05570	COG1605	Chorismate mutase
AAQM_RS05595	COG1396	sequence-specific DNA binding
AAQM_RS05610	COG2824	Alkylphosphonate utilization operon protein PhnA
AAQM_RS05645	COG1881	PFAM PEBP family protein
AAQM_RS05655	COG0840	transmembrane signaling receptor activity
AAQM_RS05670	COG0643	Histidine kinase
AAQM_RS05670	COG2198	Histidine kinase
AAQM_RS05675	COG2197	response regulator
AAQM_RS05685	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AAQM_RS05690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AAQM_RS05700	COG0784	Response regulator, receiver
AAQM_RS05700	COG3437	response regulator, receiver
AAQM_RS05710	COG3040	lipid binding
AAQM_RS05725	COG3046	protein related to deoxyribodipyrimidine photolyase
AAQM_RS05740	COG3287	FIST C domain
AAQM_RS05740	COG2200	EAL domain
AAQM_RS05740	COG2199	diguanylate cyclase activity
AAQM_RS05750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AAQM_RS05765	COG3040	lipid binding
AAQM_RS05775	COG0300	oxidoreductase activity
AAQM_RS05785	COG0488	(ABC) transporter
AAQM_RS05790	COG1607	acyl-coa hydrolase
AAQM_RS05795	COG0784	Response regulator, receiver
AAQM_RS05795	COG3437	response regulator, receiver
AAQM_RS05805	COG0840	transmembrane signaling receptor activity
AAQM_RS05810	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AAQM_RS05830	COG1733	regulation of RNA biosynthetic process
AAQM_RS05835	COG2249	NAD(P)H dehydrogenase (quinone) activity
AAQM_RS05850	COG0778	Nitroreductase
AAQM_RS05865	COG4191	Histidine kinase
AAQM_RS05875	COG0776	regulation of translation
AAQM_RS05885	COG0275	rRNA processing
AAQM_RS05915	COG0318	PFAM AMP-dependent synthetase and ligase
AAQM_RS05925	COG4865	methylaspartate mutase activity
AAQM_RS05940	COG0039	L-malate dehydrogenase activity
AAQM_RS05960	COG4591	ABC-type transport system involved in lipoprotein release permease component
AAQM_RS05965	COG0653	protein targeting
AAQM_RS05970	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AAQM_RS05985	COG1879	ABC-type sugar transport system periplasmic component
AAQM_RS05990	COG4191	Histidine kinase
AAQM_RS05990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AAQM_RS05995	COG0754	glutathionylspermidine amidase activity
AAQM_RS06005	COG0640	Transcriptional regulator
AAQM_RS06020	COG2059	Chromate
AAQM_RS06035	COG0840	transmembrane signaling receptor activity
AAQM_RS06045	COG0824	Thioesterase
AAQM_RS06055	COG0501	Belongs to the peptidase M48B family
AAQM_RS06060	COG1322	Protein conserved in bacteria
AAQM_RS06085	COG0037	tRNA processing
AAQM_RS06110	COG2203	Gaf domain
AAQM_RS06110	COG3706	GGDEF domain
AAQM_RS06110	COG4251	negative regulation of phosphorylation
AAQM_RS06110	COG5001	Diguanylate cyclase
AAQM_RS06120	COG0248	Ppx GppA phosphatase
AAQM_RS06130	COG0028	Belongs to the TPP enzyme family
AAQM_RS06135	COG0440	acetolactate synthase activity
AAQM_RS06140	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AAQM_RS06145	COG1196	nuclear chromosome segregation
AAQM_RS06145	COG1674	ftsk spoiiie
AAQM_RS06155	COG1160	GTP binding
AAQM_RS06160	COG0659	secondary active sulfate transmembrane transporter activity
AAQM_RS06180	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AAQM_RS06190	COG1185	polyribonucleotide nucleotidyltransferase activity
AAQM_RS06205	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AAQM_RS06210	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AAQM_RS06215	COG2201	protein-glutamate methylesterase activity
AAQM_RS06235	COG0582	viral genome integration into host DNA
AAQM_RS06285	COG0514	ATP-dependent DNA helicase (RecQ)
AAQM_RS06290	COG0582	viral genome integration into host DNA
AAQM_RS06295	COG3842	ATPase activity
AAQM_RS06335	COG0339	signal peptide processing
AAQM_RS06340	COG2890	protein-(glutamine-N5) methyltransferase activity
AAQM_RS06345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AAQM_RS06350	COG0494	nUDIX hydrolase
AAQM_RS06355	COG0527	aspartate kinase activity
AAQM_RS06370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AAQM_RS06375	COG0287	Prephenate dehydrogenase
AAQM_RS06380	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AAQM_RS06385	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AAQM_RS06390	COG0612	Peptidase, M16
AAQM_RS06395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AAQM_RS06425	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AAQM_RS06435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AAQM_RS06435	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AAQM_RS06455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AAQM_RS06460	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AAQM_RS06465	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AAQM_RS06605	COG0788	formyltetrahydrofolate deformylase activity
AAQM_RS06610	COG0281	malic enzyme
AAQM_RS06610	COG0280	phosphate acetyltransferase
AAQM_RS06625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AAQM_RS06690	COG0582	viral genome integration into host DNA
AAQM_RS06710	COG0667	Aldo Keto reductase
AAQM_RS06735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AAQM_RS06750	COG4206	TonB-dependent receptor
AAQM_RS06785	COG1187	pseudouridine synthase activity
AAQM_RS06790	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AAQM_RS06795	COG3706	GGDEF domain
AAQM_RS06810	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AAQM_RS06815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AAQM_RS06835	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AAQM_RS06850	COG0419	ATPase involved in DNA repair
AAQM_RS06865	COG0848	biopolymer transport protein
AAQM_RS06870	COG0811	peptide transport
AAQM_RS06880	COG4771	TonB-dependent receptor
AAQM_RS06910	COG0330	HflC and HflK could
AAQM_RS06920	COG0745	RESPONSE REGULATOR receiver
AAQM_RS06935	COG0751	glycine-tRNA ligase activity
AAQM_RS06955	COG0357	Ribosomal RNA small subunit methyltransferase G
AAQM_RS06960	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AAQM_RS06965	COG0113	porphobilinogen synthase activity
AAQM_RS06990	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AAQM_RS06990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AAQM_RS06995	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AAQM_RS07000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AAQM_RS07010	COG1663	tetraacyldisaccharide 4'-kinase activity
AAQM_RS07020	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AAQM_RS07040	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AAQM_RS07045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AAQM_RS07050	COG0805	protein transport
AAQM_RS07055	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AAQM_RS07285	COG4608	Belongs to the ABC transporter superfamily
AAQM_RS07340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AAQM_RS07350	COG0247	lactate metabolic process
AAQM_RS07350	COG2181	nitrate reductase activity
AAQM_RS07355	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AAQM_RS07375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AAQM_RS07375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AAQM_RS07380	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AAQM_RS07385	COG3287	FIST C domain
AAQM_RS07385	COG2199	diguanylate cyclase activity
AAQM_RS07385	COG2200	EAL domain
AAQM_RS07390	COG3706	GGDEF domain
AAQM_RS07395	COG1137	ATPase activity
AAQM_RS07400	COG0802	atpase or kinase
AAQM_RS07405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AAQM_RS07415	COG4771	TonB-dependent receptor
AAQM_RS07425	COG0137	argininosuccinate synthase activity
AAQM_RS07450	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AAQM_RS07455	COG0484	heat shock protein binding
AAQM_RS07460	COG0133	tryptophan synthase activity
AAQM_RS07480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AAQM_RS07485	COG5001	Diguanylate cyclase
AAQM_RS07490	COG2203	Gaf domain
AAQM_RS07490	COG3706	GGDEF domain
AAQM_RS07490	COG4251	negative regulation of phosphorylation
AAQM_RS07490	COG5001	Diguanylate cyclase
AAQM_RS07495	COG0500	methyltransferase
AAQM_RS07500	COG1333	cytochrome c biogenesis protein
AAQM_RS07500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AAQM_RS07505	COG0745	RESPONSE REGULATOR receiver
AAQM_RS07515	COG2195	Cleaves the N-terminal amino acid of tripeptides
AAQM_RS07535	COG2201	protein-glutamate methylesterase activity
AAQM_RS07550	COG0484	heat shock protein binding
AAQM_RS07555	COG0789	Transcriptional regulator
AAQM_RS07570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AAQM_RS07580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AAQM_RS07585	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AAQM_RS07595	COG0471	metal ion transport
AAQM_RS07600	COG0521	Mo-molybdopterin cofactor biosynthetic process
AAQM_RS07610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AAQM_RS07615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AAQM_RS07625	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AAQM_RS07630	COG0513	Belongs to the DEAD box helicase family
AAQM_RS07635	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AAQM_RS07645	COG3279	Response regulator of the LytR AlgR family
AAQM_RS07695	COG0642	Histidine kinase
AAQM_RS07700	COG0745	RESPONSE REGULATOR receiver
AAQM_RS07720	COG1132	(ABC) transporter
AAQM_RS07725	COG0628	permease
AAQM_RS07735	COG5001	Diguanylate cyclase
AAQM_RS07735	COG3300	MHYT domain
AAQM_RS07740	COG3118	belongs to the thioredoxin family
AAQM_RS07745	COG0450	alkyl hydroperoxide reductase
AAQM_RS07755	COG0784	Response regulator, receiver
AAQM_RS07755	COG2205	protein histidine kinase activity
AAQM_RS07755	COG5002	protein histidine kinase activity
AAQM_RS07765	COG1472	Belongs to the glycosyl hydrolase 3 family
AAQM_RS07785	COG1620	l-lactate permease
AAQM_RS07820	COG0745	RESPONSE REGULATOR receiver
AAQM_RS07835	COG1047	Peptidyl-prolyl cis-trans
AAQM_RS07840	COG0516	GMP reductase activity
AAQM_RS07840	COG0517	IMP dehydrogenase activity
AAQM_RS07845	COG0154	amidase activity
AAQM_RS07850	COG0203	ribosomal protein L17
AAQM_RS07855	COG0202	RNA polymerase activity
AAQM_RS07860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AAQM_RS07865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AAQM_RS07870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AAQM_RS07875	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AAQM_RS07890	COG0473	3-isopropylmalate dehydrogenase activity
AAQM_RS07895	COG0066	3-isopropylmalate dehydratase activity
AAQM_RS07900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AAQM_RS07920	COG3123	guanosine phosphorylase activity
AAQM_RS07925	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AAQM_RS07945	COG0772	Belongs to the SEDS family
AAQM_RS07950	COG0564	pseudouridine synthase activity
AAQM_RS07955	COG0366	Alpha amylase catalytic
AAQM_RS07955	COG3103	Sh3 type 3 domain protein
AAQM_RS07960	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AAQM_RS07965	COG2884	Cell division ATP-binding protein ftsE
AAQM_RS07980	COG1671	Belongs to the UPF0178 family
AAQM_RS07990	COG0488	(ABC) transporter
AAQM_RS08020	COG2171	N-acyltransferase activity
AAQM_RS08025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AAQM_RS08055	COG0309	Hydrogenase expression formation protein (HypE)
AAQM_RS08065	COG1401	restriction endodeoxyribonuclease activity
AAQM_RS08075	COG0409	Hydrogenase expression formation protein
AAQM_RS08080	COG0298	carbon dioxide binding
AAQM_RS08085	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AAQM_RS08105	COG0310	cobalt ion transport
AAQM_RS08125	COG2081	HI0933 family
AAQM_RS08140	COG2814	Major facilitator Superfamily
AAQM_RS08150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AAQM_RS08150	COG0301	tRNA thio-modification
AAQM_RS08165	COG3263	regulation of cellular component size
AAQM_RS08180	COG0517	IMP dehydrogenase activity
AAQM_RS08200	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AAQM_RS08215	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
AAQM_RS08220	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AAQM_RS08225	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AAQM_RS08230	COG3259	Nickel-dependent hydrogenase
AAQM_RS08245	COG1049	propionate catabolic process, 2-methylcitrate cycle
AAQM_RS08255	COG3706	GGDEF domain
AAQM_RS08255	COG2203	Gaf domain
AAQM_RS08255	COG5001	Diguanylate cyclase
AAQM_RS08255	COG4251	negative regulation of phosphorylation
AAQM_RS08265	COG1022	Amp-dependent synthetase and ligase
AAQM_RS08270	COG0183	Belongs to the thiolase family
AAQM_RS08275	COG1024	Enoyl-CoA hydratase
AAQM_RS08275	COG1250	3-hydroxyacyl-CoA dehydrogenase
AAQM_RS08280	COG1960	acyl-CoA dehydrogenase activity
AAQM_RS08315	COG0217	transcriptional regulatory protein
AAQM_RS08320	COG0739	heme binding
AAQM_RS08325	COG2853	Lipoprotein
AAQM_RS08340	COG1611	Belongs to the LOG family
AAQM_RS08345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AAQM_RS08370	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AAQM_RS08390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AAQM_RS08415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AAQM_RS08420	COG2169	Transcriptional regulator
AAQM_RS08420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AAQM_RS08435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AAQM_RS08440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AAQM_RS08445	COG2258	MOSC domain
AAQM_RS08465	COG0513	Belongs to the DEAD box helicase family
AAQM_RS08470	COG1944	ATP diphosphatase activity
AAQM_RS08490	COG0840	transmembrane signaling receptor activity
AAQM_RS08500	COG0328	RNA-DNA hybrid ribonuclease activity
AAQM_RS08515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AAQM_RS08525	COG0446	pyridine nucleotide-disulphide oxidoreductase
AAQM_RS08535	COG1104	cysteine desulfurase activity
AAQM_RS08545	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AAQM_RS08555	COG0437	4 iron, 4 sulfur cluster binding
AAQM_RS08570	COG3381	protein complex oligomerization
AAQM_RS08590	COG4565	transcriptional regulatory protein
AAQM_RS08610	COG1305	Transglutaminase-like
AAQM_RS08615	COG0709	Synthesizes selenophosphate from selenide and ATP
AAQM_RS08625	COG1921	L-seryl-tRNASec selenium transferase activity
AAQM_RS08660	COG2204	response regulator
AAQM_RS08675	COG3850	Histidine kinase
AAQM_RS08675	COG4999	Histidine kinase
AAQM_RS08675	COG3437	response regulator, receiver
AAQM_RS08675	COG2205	protein histidine kinase activity
AAQM_RS08685	COG2205	protein histidine kinase activity
AAQM_RS08685	COG0784	Response regulator, receiver
AAQM_RS08715	COG0735	belongs to the Fur family
AAQM_RS08760	COG0577	efflux transmembrane transporter activity
AAQM_RS08760	COG1136	(ABC) transporter
AAQM_RS08765	COG0577	efflux transmembrane transporter activity
AAQM_RS08765	COG1136	(ABC) transporter
AAQM_RS08785	COG0848	biopolymer transport protein
AAQM_RS08795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AAQM_RS08805	COG0133	tryptophan synthase activity
AAQM_RS08810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AAQM_RS08815	COG1793	dna ligase
AAQM_RS08825	COG0305	Participates in initiation and elongation during chromosome replication
AAQM_RS08835	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AAQM_RS08850	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AAQM_RS08855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AAQM_RS08865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AAQM_RS08870	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AAQM_RS08875	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AAQM_RS08885	COG0528	UMP kinase activity
AAQM_RS08890	COG1758	RNA polymerase activity
AAQM_RS08900	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AAQM_RS08910	COG0860	N-Acetylmuramoyl-L-alanine amidase
AAQM_RS08925	COG0193	aminoacyl-tRNA hydrolase activity
AAQM_RS08930	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AAQM_RS08935	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AAQM_RS08940	COG0681	Belongs to the peptidase S26 family
AAQM_RS08945	COG0698	ribose 5-phosphate isomerase
AAQM_RS08980	COG0556	nucleotide-excision repair
AAQM_RS08995	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AAQM_RS09000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AAQM_RS09005	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AAQM_RS09010	COG0784	Response regulator, receiver
AAQM_RS09010	COG0835	chemotaxis
AAQM_RS09015	COG0165	Argininosuccinate lyase
AAQM_RS09035	COG3706	GGDEF domain
AAQM_RS09045	COG2239	Acts as a magnesium transporter
AAQM_RS09055	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AAQM_RS09055	COG0822	iron-sulfur transferase activity
AAQM_RS09055	COG2906	2 iron, 2 sulfur cluster binding
AAQM_RS09065	COG0719	Fe-S assembly protein
AAQM_RS09070	COG0396	ATPase activity
AAQM_RS09080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AAQM_RS09085	COG2166	iron-sulfur cluster assembly
AAQM_RS09100	COG0840	transmembrane signaling receptor activity
AAQM_RS09110	COG0439	Biotin carboxylase
AAQM_RS09115	COG3706	GGDEF domain
AAQM_RS09150	COG1309	transcriptional regulator
AAQM_RS09155	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AAQM_RS09160	COG2199	diguanylate cyclase activity
AAQM_RS09160	COG2203	Gaf domain
AAQM_RS09165	COG0840	transmembrane signaling receptor activity
AAQM_RS09170	COG0840	transmembrane signaling receptor activity
AAQM_RS09200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AAQM_RS09205	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AAQM_RS09210	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AAQM_RS09230	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AAQM_RS09235	COG2814	Major facilitator Superfamily
AAQM_RS09245	COG3706	GGDEF domain
AAQM_RS09250	COG0302	gtp cyclohydrolase
AAQM_RS09255	COG0598	Magnesium transport protein CorA
AAQM_RS09260	COG1459	type II secretion system
AAQM_RS09265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AAQM_RS09280	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AAQM_RS09285	COG0606	chelatase, subunit chli
AAQM_RS09295	COG0242	peptide deformylase activity
AAQM_RS09300	COG0740	serine-type endopeptidase activity
AAQM_RS09305	COG0544	peptidyl-prolyl cis-trans isomerase activity
AAQM_RS09310	COG2304	oxidoreductase activity
AAQM_RS09315	COG2326	polyphosphate kinase activity
AAQM_RS09330	COG1773	rubredoxin
AAQM_RS09345	COG0582	viral genome integration into host DNA
AAQM_RS09410	COG3077	Addiction module antitoxin, RelB DinJ family
AAQM_RS09435	COG4681	YaeQ
AAQM_RS09455	COG0626	cystathionine gamma-synthase activity
AAQM_RS09475	COG0745	RESPONSE REGULATOR receiver
AAQM_RS09485	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AAQM_RS09500	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AAQM_RS09500	COG2111	Na H antiporter
AAQM_RS09505	COG1006	Multisubunit Na H antiporter MnhC subunit
AAQM_RS09510	COG0651	ATP synthesis coupled electron transport
AAQM_RS09515	COG1863	multisubunit Na H antiporter MnhE subunit
AAQM_RS09520	COG2212	antiporter activity
AAQM_RS09525	COG1320	monovalent cation:proton antiporter activity
AAQM_RS09530	COG1028	Short-chain dehydrogenase reductase Sdr
AAQM_RS09540	COG1858	cytochrome C peroxidase
AAQM_RS09575	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AAQM_RS09585	COG0668	transmembrane transport
AAQM_RS09610	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AAQM_RS09625	COG0348	domain, Protein
AAQM_RS09630	COG4191	Histidine kinase
AAQM_RS09635	COG4753	response regulator
AAQM_RS09635	COG2207	Transcriptional regulator
AAQM_RS09675	COG0716	FMN binding
AAQM_RS09690	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AAQM_RS09705	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AAQM_RS09710	COG0159	tryptophan synthase activity
AAQM_RS09715	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AAQM_RS09720	COG2255	four-way junction helicase activity
AAQM_RS09725	COG0628	permease
AAQM_RS09735	COG4628	conserved protein (DUF2132)
AAQM_RS09780	COG0731	radical SAM domain protein
AAQM_RS09785	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AAQM_RS09795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AAQM_RS09805	COG2841	Protein conserved in bacteria
AAQM_RS09810	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AAQM_RS09820	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AAQM_RS09830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AAQM_RS09840	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AAQM_RS09840	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AAQM_RS09845	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AAQM_RS09850	COG0859	PFAM glycosyl transferase family 9
AAQM_RS09865	COG1216	Glycosyl transferase, family 2
AAQM_RS09880	COG0438	transferase activity, transferring glycosyl groups
AAQM_RS09895	COG1696	Membrane protein involved in D-alanine export
AAQM_RS09905	COG1696	Membrane protein involved in D-alanine export
AAQM_RS09915	COG1216	Glycosyl transferase, family 2
AAQM_RS09925	COG1216	Glycosyl transferase, family 2
AAQM_RS09965	COG0859	PFAM glycosyl transferase family 9
AAQM_RS09975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AAQM_RS09985	COG0493	'glutamate synthase
AAQM_RS09990	COG0069	glutamate synthase activity
AAQM_RS09990	COG0070	glutamate synthase
AAQM_RS09990	COG0067	glutamate synthase
AAQM_RS09995	COG0584	glycerophosphoryl diester phosphodiesterase
AAQM_RS10060	COG1086	Polysaccharide biosynthesis protein
AAQM_RS10070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AAQM_RS10095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AAQM_RS10125	COG0463	Glycosyl transferase, family 2
AAQM_RS10150	COG0028	Belongs to the TPP enzyme family
AAQM_RS10180	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AAQM_RS10185	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AAQM_RS10190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AAQM_RS10195	COG0284	orotidine-5'-phosphate decarboxylase activity
AAQM_RS10210	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AAQM_RS10235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AAQM_RS10255	COG1739	Uncharacterized protein family UPF0029
AAQM_RS10260	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AAQM_RS10265	COG0196	riboflavin kinase activity
AAQM_RS10270	COG2226	methyltransferase
AAQM_RS10275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AAQM_RS10285	COG0277	FAD linked oxidase domain protein
AAQM_RS10290	COG1295	ribonuclease BN
AAQM_RS10345	COG0542	response to heat
AAQM_RS10350	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AAQM_RS10355	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AAQM_RS10370	COG2030	dehydratase
AAQM_RS10395	COG1970	mechanosensitive ion channel activity
AAQM_RS10400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AAQM_RS10430	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AAQM_RS10435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AAQM_RS10440	COG1157	protein secretion by the type III secretion system
AAQM_RS10450	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AAQM_RS10470	COG1677	Flagellar hook-basal body complex protein FliE
AAQM_RS10480	COG0455	bacterial-type flagellum organization
AAQM_RS10485	COG1419	protein localization to endoplasmic reticulum
AAQM_RS10510	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AAQM_RS10535	COG1749	Flagellar hook protein flgE
AAQM_RS10540	COG4786	Flagellar basal body rod
AAQM_RS10550	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AAQM_RS10560	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AAQM_RS10565	COG1766	The M ring may be actively involved in energy transduction
AAQM_RS10570	COG1815	bacterial-type flagellum-dependent cell motility
AAQM_RS10575	COG4786	Flagellar basal body rod
AAQM_RS10585	COG0745	RESPONSE REGULATOR receiver
AAQM_RS10605	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AAQM_RS10615	COG0228	four-way junction DNA binding
AAQM_RS10620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AAQM_RS10625	COG0564	pseudouridine synthase activity
AAQM_RS10630	COG1519	Transferase
AAQM_RS10640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AAQM_RS10645	COG0752	glycyl-tRNA synthetase alpha subunit
AAQM_RS10655	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AAQM_RS10670	COG0840	transmembrane signaling receptor activity
AAQM_RS10670	COG0840	transmembrane signaling receptor activity
AAQM_RS10675	COG0497	DNA recombination
AAQM_RS10680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AAQM_RS10685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AAQM_RS10690	COG0049	tRNA binding
AAQM_RS10695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AAQM_RS10700	COG2814	Major facilitator Superfamily
AAQM_RS10745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AAQM_RS10750	COG0085	RNA polymerase activity
AAQM_RS10755	COG0222	ribosome binding
AAQM_RS10760	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AAQM_RS10765	COG0081	regulation of translation
AAQM_RS10770	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AAQM_RS10775	COG0250	Participates in transcription elongation, termination and antitermination
AAQM_RS10790	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AAQM_RS10795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AAQM_RS10825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AAQM_RS10830	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AAQM_RS10835	COG0444	Belongs to the ABC transporter superfamily
AAQM_RS10845	COG0174	glutamine synthetase
AAQM_RS10860	COG0314	molybdopterin synthase activity
AAQM_RS10870	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AAQM_RS10885	COG0772	Belongs to the SEDS family
AAQM_RS10895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AAQM_RS10935	COG0512	Glutamine amidotransferase of anthranilate synthase
AAQM_RS10940	COG1840	ABC-type Fe3 transport system, periplasmic component
AAQM_RS10945	COG1178	ABC-type Fe3 transport system permease component
AAQM_RS10950	COG3842	ATPase activity
AAQM_RS10980	COG2183	response to ionizing radiation
AAQM_RS10990	COG5002	protein histidine kinase activity
AAQM_RS10990	COG5001	Diguanylate cyclase
AAQM_RS10995	COG0251	oxidation-reduction process
AAQM_RS11010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AAQM_RS11025	COG0335	large ribosomal subunit rRNA binding
AAQM_RS11030	COG0336	Belongs to the RNA methyltransferase TrmD family
AAQM_RS11040	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AAQM_RS11045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AAQM_RS11050	COG0356	it plays a direct role in the translocation of protons across the membrane
AAQM_RS11055	COG0352	thiamine-phosphate diphosphorylase activity
AAQM_RS11060	COG1074	ATP-dependent DNA helicase activity
AAQM_RS11065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AAQM_RS11070	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AAQM_RS11075	COG0723	plastoquinol--plastocyanin reductase activity
AAQM_RS11080	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AAQM_RS11095	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AAQM_RS11110	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AAQM_RS11120	COG0602	queuosine metabolic process
AAQM_RS11125	COG1028	Short-chain dehydrogenase reductase Sdr
AAQM_RS11130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AAQM_RS11135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AAQM_RS11140	COG0825	malonyl-CoA metabolic process
AAQM_RS11145	COG0537	adenosine 5'-monophosphoramidase activity
AAQM_RS11150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AAQM_RS11155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AAQM_RS11155	COG0072	phenylalanine-tRNA ligase activity
AAQM_RS11160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AAQM_RS11165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AAQM_RS11170	COG0539	negative regulation of cytoplasmic translation
AAQM_RS11170	COG1185	polyribonucleotide nucleotidyltransferase activity
AAQM_RS11175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AAQM_RS11180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AAQM_RS11185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AAQM_RS11185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AAQM_RS11190	COG0779	Required for maturation of 30S ribosomal subunits
AAQM_RS11195	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AAQM_RS11200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AAQM_RS11210	COG0083	homoserine kinase activity
AAQM_RS11220	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AAQM_RS11230	COG2404	hydrolase activity, acting on ester bonds
AAQM_RS11235	COG0157	Belongs to the NadC ModD family
AAQM_RS11245	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AAQM_RS11255	COG4773	Receptor
AAQM_RS11265	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AAQM_RS11305	COG3278	Belongs to the heme-copper respiratory oxidase family
AAQM_RS11310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AAQM_RS11315	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AAQM_RS11320	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AAQM_RS11325	COG0210	DNA helicase
AAQM_RS11335	COG1242	4 iron, 4 sulfur cluster binding
AAQM_RS11340	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AAQM_RS11345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AAQM_RS11350	COG0492	ferredoxin-NADP+ reductase activity
AAQM_RS11355	COG3118	belongs to the thioredoxin family
AAQM_RS11360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AAQM_RS11385	COG0791	NLP P60 protein
AAQM_RS11390	COG0791	NLP P60 protein
AAQM_RS11400	COG0697	spore germination
AAQM_RS11405	COG0424	maF-like protein
AAQM_RS11415	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AAQM_RS11420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AAQM_RS11425	COG1605	Chorismate mutase
AAQM_RS11425	COG0077	Prephenate dehydratase
AAQM_RS11430	COG0019	diaminopimelate decarboxylase activity
AAQM_RS11435	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AAQM_RS11440	COG0149	triose-phosphate isomerase activity
AAQM_RS11445	COG0126	phosphoglycerate kinase activity
AAQM_RS11450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AAQM_RS11455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AAQM_RS11465	COG0018	arginyl-trna synthetase
AAQM_RS11470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AAQM_RS11475	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AAQM_RS11480	COG0204	Acyl-transferase
AAQM_RS11490	COG0047	phosphoribosylformylglycinamidine synthase activity
AAQM_RS11495	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AAQM_RS11500	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AAQM_RS11505	COG0793	Belongs to the peptidase S41A family
AAQM_RS11520	COG0585	pseudouridine synthase activity
AAQM_RS11535	COG0577	efflux transmembrane transporter activity
AAQM_RS11535	COG1136	(ABC) transporter
AAQM_RS11605	COG0129	dihydroxy-acid dehydratase activity
AAQM_RS11615	COG0745	RESPONSE REGULATOR receiver
AAQM_RS11620	COG0642	Histidine kinase
AAQM_RS11630	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AAQM_RS11635	COG0702	epimerase
AAQM_RS11640	COG1492	cobalamin metabolic process
AAQM_RS11670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AAQM_RS11675	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AAQM_RS11685	COG2095	MarC family integral membrane protein
AAQM_RS11690	COG2755	lipolytic protein G-D-S-L family
AAQM_RS11690	COG1083	cytidylyl-transferase
AAQM_RS11695	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AAQM_RS11710	COG4232	protein-disulfide reductase activity
AAQM_RS11715	COG3118	belongs to the thioredoxin family
AAQM_RS11720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AAQM_RS11735	COG0189	ligase activity
AAQM_RS11750	COG2200	EAL domain
AAQM_RS11750	COG3287	FIST C domain
AAQM_RS11750	COG2199	diguanylate cyclase activity
AAQM_RS11755	COG0688	phosphatidylethanolamine metabolic process
AAQM_RS11765	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AAQM_RS11775	COG0443	Heat shock 70 kDa protein
AAQM_RS11780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AAQM_RS11800	COG2204	response regulator
AAQM_RS11810	COG0101	tRNA pseudouridine synthase activity
AAQM_RS11820	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AAQM_RS11825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AAQM_RS11830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AAQM_RS11835	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AAQM_RS11845	COG4581	dead DEAH box helicase
AAQM_RS11850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AAQM_RS11870	COG2089	acid synthase
AAQM_RS11885	COG1083	cytidylyl-transferase
AAQM_RS11890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AAQM_RS11895	COG1086	Polysaccharide biosynthesis protein
AAQM_RS11920	COG0673	inositol 2-dehydrogenase activity
AAQM_RS11945	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AAQM_RS11950	COG0148	phosphopyruvate hydratase activity
AAQM_RS11965	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AAQM_RS11980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AAQM_RS11985	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AAQM_RS11995	COG1007	ATP synthesis coupled electron transport
AAQM_RS12005	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AAQM_RS12010	COG0713	ATP synthesis coupled electron transport
AAQM_RS12015	COG0839	Belongs to the complex I subunit 6 family
AAQM_RS12020	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAQM_RS12025	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AAQM_RS12045	COG0649	NAD binding
AAQM_RS12050	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAQM_RS12055	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAQM_RS12060	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AAQM_RS12065	COG1222	aaa ATPase
AAQM_RS12090	COG0659	secondary active sulfate transmembrane transporter activity
AAQM_RS12095	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AAQM_RS12100	COG1252	NADH dehydrogenase
AAQM_RS12105	COG0733	neurotransmitter:sodium symporter activity
AAQM_RS12115	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AAQM_RS12125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AAQM_RS12130	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AAQM_RS12135	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AAQM_RS12155	COG0445	tRNA wobble uridine modification
AAQM_RS12165	COG0708	Exodeoxyribonuclease III
AAQM_RS12175	COG0210	DNA helicase
AAQM_RS12210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AAQM_RS12235	COG0348	domain, Protein
AAQM_RS12240	COG0504	CTP synthase activity
AAQM_RS12245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AAQM_RS12245	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AAQM_RS12275	COG0587	DNA-directed DNA polymerase activity
AAQM_RS12280	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AAQM_RS12290	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AAQM_RS12295	COG0315	cyclic pyranopterin monophosphate synthase activity
AAQM_RS12330	COG0670	Belongs to the BI1 family
AAQM_RS12335	COG0352	thiamine-phosphate diphosphorylase activity
AAQM_RS12345	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AAQM_RS12355	COG0233	cytoplasmic translational termination
AAQM_RS12360	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AAQM_RS12370	COG2814	Major facilitator Superfamily
AAQM_RS12375	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AAQM_RS12375	COG3264	Mechanosensitive ion channel
AAQM_RS12385	COG3022	response to hydroperoxide
AAQM_RS12390	COG3012	SEC-C Motif Domain Protein
AAQM_RS12415	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AAQM_RS12420	COG1012	belongs to the aldehyde dehydrogenase family
AAQM_RS12430	COG1704	LemA family
AAQM_RS12445	COG0546	phosphoglycolate phosphatase activity
AAQM_RS12460	COG2814	Major facilitator Superfamily
AAQM_RS12465	COG0840	transmembrane signaling receptor activity
AAQM_RS12500	COG2081	HI0933 family
AAQM_RS12515	COG1959	2 iron, 2 sulfur cluster binding
AAQM_RS12530	COG0175	sulfate reduction
AAQM_RS12535	COG0175	sulfate reduction
AAQM_RS12540	COG2895	sulfate adenylyltransferase (ATP) activity
AAQM_RS12545	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AAQM_RS12565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AAQM_RS12570	COG1408	metallophosphoesterase
AAQM_RS12575	COG0071	Belongs to the small heat shock protein (HSP20) family
AAQM_RS12590	COG1305	Transglutaminase-like
AAQM_RS12595	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AAQM_RS12600	COG4208	sulfate ABC transporter
AAQM_RS12605	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AAQM_RS12610	COG3287	FIST C domain
AAQM_RS12610	COG2199	diguanylate cyclase activity
AAQM_RS12610	COG2200	EAL domain
AAQM_RS12615	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AAQM_RS12620	COG1959	2 iron, 2 sulfur cluster binding
AAQM_RS12640	COG2308	Evidence 4 Homologs of previously reported genes of
AAQM_RS12650	COG1368	sulfuric ester hydrolase activity
AAQM_RS12665	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AAQM_RS12685	COG0745	RESPONSE REGULATOR receiver
AAQM_RS12690	COG0642	Histidine kinase
AAQM_RS12700	COG0425	Belongs to the sulfur carrier protein TusA family
AAQM_RS12705	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AAQM_RS12710	COG2066	Belongs to the glutaminase family
AAQM_RS12715	COG2860	membrane
AAQM_RS12725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AAQM_RS12730	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group