locus-tag	class	description
FM022_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FM022_RS00015	COG0592	DNA-directed DNA polymerase activity
FM022_RS00020	COG0187	DNA topoisomerase II activity
FM022_RS00025	COG0492	ferredoxin-NADP+ reductase activity
FM022_RS00030	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FM022_RS00040	COG1238	metal cluster binding
FM022_RS00045	COG0500	methyltransferase
FM022_RS00050	COG3842	ATPase activity
FM022_RS00095	COG0564	pseudouridine synthase activity
FM022_RS00100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FM022_RS00105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FM022_RS00140	COG0604	alcohol dehydrogenase
FM022_RS00145	COG1733	regulation of RNA biosynthetic process
FM022_RS00150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FM022_RS00155	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FM022_RS00170	COG1620	l-lactate permease
FM022_RS00175	COG0745	RESPONSE REGULATOR receiver
FM022_RS00180	COG3852	Histidine kinase
FM022_RS00185	COG1556	Lactate utilization protein
FM022_RS00190	COG1139	Iron-sulfur cluster binding protein
FM022_RS00195	COG0247	lactate metabolic process
FM022_RS00200	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FM022_RS00205	COG0511	ligase activity, forming carbon-carbon bonds
FM022_RS00210	COG0439	Biotin carboxylase
FM022_RS00215	COG0513	Belongs to the DEAD box helicase family
FM022_RS00220	COG0306	phosphate transporter
FM022_RS00230	COG0367	asparagine synthase
FM022_RS00245	COG1981	membrane
FM022_RS00250	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FM022_RS00250	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FM022_RS00260	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FM022_RS00260	COG0517	IMP dehydrogenase activity
FM022_RS00265	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FM022_RS00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FM022_RS00275	COG0107	imidazoleglycerol-phosphate synthase activity
FM022_RS00290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FM022_RS00295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FM022_RS00300	COG0724	RNA recognition motif
FM022_RS00310	COG0642	Histidine kinase
FM022_RS00365	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FM022_RS00370	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FM022_RS00375	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FM022_RS00395	COG0746	molybdenum cofactor guanylyltransferase activity
FM022_RS00400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FM022_RS00405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FM022_RS00410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FM022_RS00415	COG0268	Binds directly to 16S ribosomal RNA
FM022_RS00420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FM022_RS00430	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FM022_RS00435	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FM022_RS00440	COG0573	inorganic phosphate transmembrane transporter activity
FM022_RS00445	COG0581	inorganic phosphate transmembrane transporter activity
FM022_RS00450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FM022_RS00465	COG0745	RESPONSE REGULATOR receiver
FM022_RS00470	COG5002	protein histidine kinase activity
FM022_RS00475	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FM022_RS00480	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FM022_RS00490	COG0546	phosphoglycolate phosphatase activity
FM022_RS00515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FM022_RS00520	COG1854	S-ribosylhomocysteine lyase activity
FM022_RS00535	COG1686	Belongs to the peptidase S11 family
FM022_RS00550	COG0646	methionine synthase
FM022_RS00550	COG1410	methionine synthase
FM022_RS00570	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FM022_RS00570	COG0140	phosphoribosyl-ATP diphosphatase activity
FM022_RS00580	COG0489	protein tyrosine kinase activity
FM022_RS00585	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FM022_RS00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FM022_RS00595	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FM022_RS00605	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FM022_RS00610	COG0505	Belongs to the CarA family
FM022_RS00620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FM022_RS00625	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FM022_RS00630	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FM022_RS00635	COG2353	YceI-like domain
FM022_RS00640	COG1846	Transcriptional regulator
FM022_RS00645	COG2353	YceI-like domain
FM022_RS00665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FM022_RS00670	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FM022_RS00675	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FM022_RS00680	COG0237	dephospho-CoA kinase activity
FM022_RS00685	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FM022_RS00690	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FM022_RS00695	COG0456	acetyltransferase
FM022_RS00725	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FM022_RS00730	COG0254	rRNA binding
FM022_RS00735	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FM022_RS00750	COG0436	Aminotransferase
FM022_RS00755	COG0460	homoserine dehydrogenase
FM022_RS00765	COG0575	Belongs to the CDS family
FM022_RS00770	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FM022_RS00785	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FM022_RS00790	COG0023	Translation Initiation Factor
FM022_RS00795	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FM022_RS00795	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FM022_RS00800	COG1324	tolerance protein
FM022_RS00805	COG2022	thiamine diphosphate biosynthetic process
FM022_RS00880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FM022_RS00890	COG1346	cytolysis
FM022_RS00900	COG3766	membrane
FM022_RS00905	COG1301	dicarboxylic acid transport
FM022_RS00925	COG4589	Belongs to the CDS family
FM022_RS00935	COG0318	PFAM AMP-dependent synthetase and ligase
FM022_RS00935	COG0204	Acyl-transferase
FM022_RS00940	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FM022_RS00955	COG0666	response to abiotic stimulus
FM022_RS00965	COG0418	dihydroorotase activity
FM022_RS00975	COG1706	bacterial-type flagellum-dependent cell motility
FM022_RS01010	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FM022_RS01040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FM022_RS01045	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FM022_RS01050	COG0601	transmembrane transport
FM022_RS01060	COG0786	glutamate:sodium symporter activity
FM022_RS01065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FM022_RS01075	COG0560	Phosphoserine phosphatase
FM022_RS01085	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FM022_RS01090	COG3248	Nucleoside-binding outer membrane protein
FM022_RS01095	COG1393	Belongs to the ArsC family
FM022_RS01100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FM022_RS01105	COG0343	queuine tRNA-ribosyltransferase activity
FM022_RS01115	COG0436	Aminotransferase
FM022_RS01140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FM022_RS01145	COG0557	exoribonuclease II activity
FM022_RS01150	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
FM022_RS01160	COG0360	Binds together with S18 to 16S ribosomal RNA
FM022_RS01165	COG0629	single-stranded DNA binding
FM022_RS01170	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FM022_RS01180	COG0215	cysteine-tRNA ligase activity
FM022_RS01185	COG0195	Participates in both transcription termination and antitermination
FM022_RS01195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FM022_RS01200	COG2121	Domain of unknown function (DUF374)
FM022_RS01210	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FM022_RS01220	COG0288	reversible hydration of carbon dioxide
FM022_RS01225	COG0156	8-amino-7-oxononanoate synthase activity
FM022_RS01230	COG0792	nuclease activity
FM022_RS01260	COG0540	Belongs to the ATCase OTCase family
FM022_RS01265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FM022_RS01280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FM022_RS01285	COG2824	Alkylphosphonate utilization operon protein PhnA
FM022_RS01290	COG1451	nucleotide metabolic process
FM022_RS01295	COG0730	response to heat
FM022_RS01320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FM022_RS01330	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FM022_RS01335	COG0372	Belongs to the citrate synthase family
FM022_RS01340	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FM022_RS01345	COG2828	Protein conserved in bacteria
FM022_RS01355	COG1335	isochorismatase
FM022_RS01365	COG0181	hydroxymethylbilane synthase activity
FM022_RS01375	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FM022_RS01380	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FM022_RS01385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FM022_RS01390	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FM022_RS01395	COG0450	alkyl hydroperoxide reductase
FM022_RS01405	COG0105	UTP biosynthetic process
FM022_RS01415	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FM022_RS01420	COG0416	fatty acid biosynthetic process
FM022_RS01425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FM022_RS01445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FM022_RS01450	COG1053	succinate dehydrogenase
FM022_RS01460	COG1007	ATP synthesis coupled electron transport
FM022_RS01470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FM022_RS01475	COG0713	ATP synthesis coupled electron transport
FM022_RS01480	COG0839	Belongs to the complex I subunit 6 family
FM022_RS01485	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FM022_RS01490	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FM022_RS01495	COG1034	ATP synthesis coupled electron transport
FM022_RS01500	COG0372	Belongs to the citrate synthase family
FM022_RS01515	COG0649	NAD binding
FM022_RS01515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FM022_RS01520	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FM022_RS01525	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FM022_RS01535	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FM022_RS01540	COG3610	response to peptide
FM022_RS01545	COG2966	Psort location CytoplasmicMembrane, score
FM022_RS01560	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FM022_RS01585	COG4774	siderophore transport
FM022_RS01610	COG4771	TonB-dependent receptor
FM022_RS01620	COG1971	Probably functions as a manganese efflux pump
FM022_RS01655	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FM022_RS01660	COG1333	cytochrome c biogenesis protein
FM022_RS01660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FM022_RS01665	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FM022_RS01670	COG3005	denitrification pathway
FM022_RS01680	COG2199	diguanylate cyclase activity
FM022_RS01680	COG3287	FIST C domain
FM022_RS01680	COG2200	EAL domain
FM022_RS01685	COG0840	transmembrane signaling receptor activity
FM022_RS01705	COG3043	anaerobic respiration
FM022_RS01710	COG0348	domain, Protein
FM022_RS01715	COG0437	4 iron, 4 sulfur cluster binding
FM022_RS01720	COG0243	molybdopterin cofactor binding
FM022_RS01730	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FM022_RS01735	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FM022_RS01745	COG2207	Transcriptional regulator
FM022_RS01745	COG4753	response regulator
FM022_RS01750	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FM022_RS01755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FM022_RS01755	COG1648	precorrin-2 dehydrogenase activity
FM022_RS01770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FM022_RS01775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FM022_RS01780	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FM022_RS01790	COG2404	hydrolase activity, acting on ester bonds
FM022_RS01795	COG1832	CoA-binding protein
FM022_RS01800	COG0642	Histidine kinase
FM022_RS01805	COG0745	RESPONSE REGULATOR receiver
FM022_RS01810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FM022_RS01815	COG0191	fructose-bisphosphate aldolase activity
FM022_RS01835	COG0811	peptide transport
FM022_RS01845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FM022_RS01850	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FM022_RS01860	COG0142	geranyltranstransferase activity
FM022_RS01865	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FM022_RS01870	COG0442	prolyl-tRNA aminoacylation
FM022_RS01875	COG0668	transmembrane transport
FM022_RS01905	COG1862	Preprotein translocase
FM022_RS01910	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FM022_RS01915	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FM022_RS01930	COG1360	Flagellar Motor Protein
FM022_RS01935	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FM022_RS01945	COG0495	leucyl-tRNA aminoacylation
FM022_RS01955	COG0285	dihydrofolate synthase activity
FM022_RS01985	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FM022_RS02005	COG0745	RESPONSE REGULATOR receiver
FM022_RS02015	COG2081	HI0933 family
FM022_RS02020	COG0840	transmembrane signaling receptor activity
FM022_RS02040	COG1692	metallophosphoesterase
FM022_RS02055	COG2226	methyltransferase
FM022_RS02060	COG1570	exodeoxyribonuclease VII activity
FM022_RS02065	COG0835	chemotaxis
FM022_RS02070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FM022_RS02075	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FM022_RS02080	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FM022_RS02090	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FM022_RS02095	COG0459	protein refolding
FM022_RS02105	COG0745	RESPONSE REGULATOR receiver
FM022_RS02110	COG1408	metallophosphoesterase
FM022_RS02135	COG1136	(ABC) transporter
FM022_RS02155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FM022_RS02160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FM022_RS02165	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FM022_RS02170	COG0352	thiamine-phosphate diphosphorylase activity
FM022_RS02175	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FM022_RS02185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FM022_RS02190	COG2264	protein methyltransferase activity
FM022_RS02195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FM022_RS02210	COG3437	response regulator, receiver
FM022_RS02210	COG0784	Response regulator, receiver
FM022_RS02225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FM022_RS02240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FM022_RS02250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FM022_RS02290	COG1132	(ABC) transporter
FM022_RS02310	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FM022_RS02315	COG1090	epimerase
FM022_RS02340	COG0481	GTPase activity
FM022_RS02345	COG1937	Protein conserved in bacteria
FM022_RS02360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FM022_RS02370	COG0482	sulfurtransferase activity
FM022_RS02375	COG0482	sulfurtransferase activity
FM022_RS02380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FM022_RS02385	COG0006	proline dipeptidase activity
FM022_RS02390	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FM022_RS02395	COG0402	S-adenosylhomocysteine deaminase activity
FM022_RS02400	COG0616	signal peptide processing
FM022_RS02410	COG0280	phosphate acetyltransferase
FM022_RS02415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FM022_RS02430	COG2176	DNA-directed DNA polymerase activity
FM022_RS02460	COG2176	DNA-directed DNA polymerase activity
FM022_RS02470	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FM022_RS02485	COG5002	protein histidine kinase activity
FM022_RS02530	COG1058	Belongs to the CinA family
FM022_RS02530	COG1546	Belongs to the CinA family
FM022_RS02535	COG0579	oxidoreductase
FM022_RS02540	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FM022_RS02555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FM022_RS02580	COG4585	Histidine kinase
FM022_RS02595	COG0667	Aldo Keto reductase
FM022_RS02600	COG0306	phosphate transporter
FM022_RS02605	COG0840	transmembrane signaling receptor activity
FM022_RS02615	COG0840	transmembrane signaling receptor activity
FM022_RS02645	COG0824	Thioesterase
FM022_RS02655	COG0501	Belongs to the peptidase M48B family
FM022_RS02660	COG1322	Protein conserved in bacteria
FM022_RS02680	COG0037	tRNA processing
FM022_RS02700	COG0052	Belongs to the universal ribosomal protein uS2 family
FM022_RS02705	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FM022_RS02710	COG1136	(ABC) transporter
FM022_RS02720	COG0194	GDP metabolic process
FM022_RS02725	COG5001	Diguanylate cyclase
FM022_RS02725	COG5002	protein histidine kinase activity
FM022_RS02730	COG2217	Heavy metal translocating P-type atpase
FM022_RS02745	COG4608	Belongs to the ABC transporter superfamily
FM022_RS02750	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FM022_RS02765	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FM022_RS02770	COG1121	(ABC) transporter
FM022_RS02775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FM022_RS02780	COG2996	Protein conserved in bacteria
FM022_RS02785	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FM022_RS02805	COG0210	DNA helicase
FM022_RS02810	COG0569	domain protein
FM022_RS02810	COG0475	glutathione-regulated potassium exporter activity
FM022_RS02815	COG0525	valine-tRNA ligase activity
FM022_RS02820	COG4895	conserved protein (DUF2196)
FM022_RS02830	COG2814	Major facilitator Superfamily
FM022_RS02835	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FM022_RS02855	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FM022_RS02860	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FM022_RS02865	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FM022_RS02940	COG0439	Biotin carboxylase
FM022_RS02945	COG2151	metal-sulfur cluster biosynthetic enzyme
FM022_RS02950	COG2166	iron-sulfur cluster assembly
FM022_RS02955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FM022_RS02965	COG0396	ATPase activity
FM022_RS02970	COG0719	Fe-S assembly protein
FM022_RS02980	COG0822	iron-sulfur transferase activity
FM022_RS02980	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FM022_RS02980	COG2906	2 iron, 2 sulfur cluster binding
FM022_RS02985	COG2239	Acts as a magnesium transporter
FM022_RS02990	COG3706	GGDEF domain
FM022_RS02995	COG0165	Argininosuccinate lyase
FM022_RS03000	COG0835	chemotaxis
FM022_RS03000	COG0784	Response regulator, receiver
FM022_RS03005	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FM022_RS03010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FM022_RS03020	COG0556	nucleotide-excision repair
FM022_RS03030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FM022_RS03050	COG0840	transmembrane signaling receptor activity
FM022_RS03100	COG0698	ribose 5-phosphate isomerase
FM022_RS03105	COG0681	Belongs to the peptidase S26 family
FM022_RS03110	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FM022_RS03115	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FM022_RS03120	COG0193	aminoacyl-tRNA hydrolase activity
FM022_RS03145	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FM022_RS03160	COG0528	UMP kinase activity
FM022_RS03170	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FM022_RS03175	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FM022_RS03180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FM022_RS03190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FM022_RS03195	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FM022_RS03205	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FM022_RS03215	COG0305	Participates in initiation and elongation during chromosome replication
FM022_RS03230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FM022_RS03240	COG2089	acid synthase
FM022_RS03245	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FM022_RS03255	COG1083	cytidylyl-transferase
FM022_RS03260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FM022_RS03270	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FM022_RS03290	COG1028	Short-chain dehydrogenase reductase Sdr
FM022_RS03305	COG0110	maltose O-acetyltransferase activity
FM022_RS03340	COG1086	Polysaccharide biosynthesis protein
FM022_RS03365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FM022_RS03370	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FM022_RS03385	COG1793	dna ligase
FM022_RS03390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FM022_RS03395	COG0133	tryptophan synthase activity
FM022_RS03415	COG0848	biopolymer transport protein
FM022_RS03435	COG1136	(ABC) transporter
FM022_RS03435	COG0577	efflux transmembrane transporter activity
FM022_RS03440	COG1136	(ABC) transporter
FM022_RS03440	COG0577	efflux transmembrane transporter activity
FM022_RS03485	COG0735	belongs to the Fur family
FM022_RS03495	COG0114	fumarate hydratase activity
FM022_RS03505	COG3920	Histidine kinase
FM022_RS03510	COG0784	Response regulator, receiver
FM022_RS03515	COG4774	siderophore transport
FM022_RS03520	COG3128	pkhd-type hydroxylase
FM022_RS03530	COG4771	TonB-dependent receptor
FM022_RS03550	COG1966	Carbon starvation protein
FM022_RS03555	COG0012	GTP binding
FM022_RS03575	COG3123	guanosine phosphorylase activity
FM022_RS03585	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FM022_RS03590	COG0585	pseudouridine synthase activity
FM022_RS03605	COG0632	four-way junction helicase activity
FM022_RS03610	COG1181	Belongs to the D-alanine--D-alanine ligase family
FM022_RS03635	COG0051	transcription antitermination factor activity, RNA binding
FM022_RS03640	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FM022_RS03645	COG0088	Forms part of the polypeptide exit tunnel
FM022_RS03650	COG0089	rRNA binding
FM022_RS03655	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FM022_RS03660	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FM022_RS03665	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FM022_RS03670	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FM022_RS03675	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FM022_RS03680	COG0255	Belongs to the universal ribosomal protein uL29 family
FM022_RS03685	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FM022_RS03690	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FM022_RS03695	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FM022_RS03700	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FM022_RS03705	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FM022_RS03710	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FM022_RS03715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FM022_RS03720	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FM022_RS03725	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FM022_RS03730	COG0200	Binds to the 23S rRNA
FM022_RS03735	COG0201	protein transport
FM022_RS03740	COG0024	Methionine aminopeptidase
FM022_RS03745	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FM022_RS03750	COG1573	uracil-dna glycosylase
FM022_RS03760	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FM022_RS03780	COG0563	adenylate kinase activity
FM022_RS03805	COG1979	alcohol dehydrogenase
FM022_RS03810	COG0840	transmembrane signaling receptor activity
FM022_RS03815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FM022_RS03820	COG0322	excinuclease ABC activity
FM022_RS03825	COG0840	transmembrane signaling receptor activity
FM022_RS03835	COG0840	transmembrane signaling receptor activity
FM022_RS03840	COG0840	transmembrane signaling receptor activity
FM022_RS03890	COG3706	GGDEF domain
FM022_RS03895	COG0708	Exodeoxyribonuclease III
FM022_RS03915	COG3040	lipid binding
FM022_RS03930	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FM022_RS03940	COG2200	EAL domain
FM022_RS03945	COG3279	Response regulator of the LytR AlgR family
FM022_RS03950	COG3275	phosphorelay sensor kinase activity
FM022_RS03955	COG1233	COG1233 Phytoene dehydrogenase and related
FM022_RS03960	COG0415	Belongs to the DNA photolyase family
FM022_RS03980	COG0166	Belongs to the GPI family
FM022_RS04025	COG0840	transmembrane signaling receptor activity
FM022_RS04030	COG1942	4-Oxalocrotonate Tautomerase
FM022_RS04035	COG0583	DNA-binding transcription factor activity
FM022_RS04040	COG0134	indole-3-glycerol-phosphate synthase activity
FM022_RS04050	COG0727	PFAM Uncharacterised protein family (UPF0153)
FM022_RS04065	COG0674	pyruvate-flavodoxin oxidoreductase activity
FM022_RS04065	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FM022_RS04070	COG1013	pyruvate-flavodoxin oxidoreductase activity
FM022_RS04080	COG2176	DNA-directed DNA polymerase activity
FM022_RS04085	COG0135	phosphoribosylanthranilate isomerase activity
FM022_RS04090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FM022_RS04110	COG1666	GTP binding
FM022_RS04120	COG2363	Small membrane protein
FM022_RS04125	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FM022_RS04140	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FM022_RS04145	COG0750	zinc metalloprotease
FM022_RS04155	COG1028	Short-chain dehydrogenase reductase Sdr
FM022_RS04160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FM022_RS04170	COG0167	dihydroorotate dehydrogenase activity
FM022_RS04175	COG1132	(ABC) transporter
FM022_RS04180	COG0728	peptidoglycan biosynthetic process
FM022_RS04195	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FM022_RS04205	COG3340	Belongs to the peptidase S51 family
FM022_RS04210	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FM022_RS04215	COG3150	esterase
FM022_RS04220	COG1858	cytochrome C peroxidase
FM022_RS04235	COG0552	protein localization to endoplasmic reticulum
FM022_RS04240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FM022_RS04245	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FM022_RS04250	COG1418	mRNA catabolic process
FM022_RS04255	COG0742	ribosomal rna small subunit methyltransferase
FM022_RS04260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FM022_RS04265	COG0300	oxidoreductase activity
FM022_RS04285	COG3258	Cytochrome c
FM022_RS04295	COG0745	RESPONSE REGULATOR receiver
FM022_RS04300	COG0642	Histidine kinase
FM022_RS04305	COG0157	Belongs to the NadC ModD family
FM022_RS04315	COG1610	YqeY-like protein
FM022_RS04320	COG0488	(ABC) transporter
FM022_RS04330	COG0492	ferredoxin-NADP+ reductase activity
FM022_RS04335	COG0596	Alpha beta hydrolase
FM022_RS04370	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FM022_RS04370	COG0519	Catalyzes the synthesis of GMP from XMP
FM022_RS04375	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FM022_RS04385	COG1451	nucleotide metabolic process
FM022_RS04390	COG0436	Aminotransferase
FM022_RS04395	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FM022_RS04440	COG2223	nitrite transmembrane transporter activity
FM022_RS04450	COG0310	cobalt ion transport
FM022_RS04470	COG2831	hemolysin activation secretion protein
FM022_RS04475	COG3210	domain, Protein
FM022_RS04475	COG3210	domain, Protein
FM022_RS04515	COG3077	Addiction module antitoxin, RelB DinJ family
FM022_RS04530	COG0628	permease
FM022_RS04555	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FM022_RS04565	COG0840	transmembrane signaling receptor activity
FM022_RS04570	COG0730	response to heat
FM022_RS04575	COG1045	serine acetyltransferase
FM022_RS04580	COG1166	arginine decarboxylase activity
FM022_RS04585	COG0124	histidyl-tRNA synthetase
FM022_RS04590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FM022_RS04595	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FM022_RS04600	COG0163	prenyltransferase activity
FM022_RS04610	COG0359	binds to the 23S rRNA
FM022_RS04615	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FM022_RS04640	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FM022_RS04645	COG0131	Imidazoleglycerol-phosphate dehydratase
FM022_RS04650	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FM022_RS04665	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FM022_RS04670	COG0456	acetyltransferase
FM022_RS04690	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FM022_RS04730	COG3437	response regulator, receiver
FM022_RS04730	COG0784	Response regulator, receiver
FM022_RS04740	COG0768	penicillin binding
FM022_RS04760	COG2884	Cell division ATP-binding protein ftsE
FM022_RS04765	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FM022_RS04775	COG0564	pseudouridine synthase activity
FM022_RS04790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FM022_RS04795	COG3123	guanosine phosphorylase activity
FM022_RS04815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FM022_RS04820	COG0066	3-isopropylmalate dehydratase activity
FM022_RS04825	COG0473	3-isopropylmalate dehydrogenase activity
FM022_RS04840	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FM022_RS04845	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FM022_RS04850	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FM022_RS04855	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FM022_RS04860	COG0202	RNA polymerase activity
FM022_RS04865	COG0203	ribosomal protein L17
FM022_RS04870	COG0154	amidase activity
FM022_RS04875	COG0516	GMP reductase activity
FM022_RS04875	COG0517	IMP dehydrogenase activity
FM022_RS04925	COG0484	heat shock protein binding
FM022_RS04945	COG2205	protein histidine kinase activity
FM022_RS04945	COG0784	Response regulator, receiver
FM022_RS04965	COG1119	ATPase activity
FM022_RS05000	COG1733	regulation of RNA biosynthetic process
FM022_RS05005	COG2249	NAD(P)H dehydrogenase (quinone) activity
FM022_RS05015	COG2076	Multidrug Resistance protein
FM022_RS05030	COG1881	PFAM PEBP family protein
FM022_RS05035	COG0583	DNA-binding transcription factor activity
FM022_RS05070	COG1733	regulation of RNA biosynthetic process
FM022_RS05075	COG2249	NAD(P)H dehydrogenase (quinone) activity
FM022_RS05080	COG2249	NAD(P)H dehydrogenase (quinone) activity
FM022_RS05085	COG0778	Nitroreductase
FM022_RS05105	COG0778	Nitroreductase
FM022_RS05115	COG0488	(ABC) transporter
FM022_RS05120	COG1607	acyl-coa hydrolase
FM022_RS05130	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FM022_RS05135	COG0754	glutathionylspermidine amidase activity
FM022_RS05150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FM022_RS05160	COG1496	oxidoreductase activity
FM022_RS05165	COG0280	phosphate acetyltransferase
FM022_RS05165	COG0281	malic enzyme
FM022_RS05170	COG0788	formyltetrahydrofolate deformylase activity
FM022_RS05175	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FM022_RS05200	COG0745	RESPONSE REGULATOR receiver
FM022_RS05210	COG0330	HflC and HflK could
FM022_RS05235	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FM022_RS05245	COG0546	phosphoglycolate phosphatase activity
FM022_RS05265	COG4206	TonB-dependent receptor
FM022_RS05270	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FM022_RS05275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FM022_RS05280	COG0475	glutathione-regulated potassium exporter activity
FM022_RS05285	COG0406	alpha-ribazole phosphatase activity
FM022_RS05290	COG1132	(ABC) transporter
FM022_RS05300	COG0745	RESPONSE REGULATOR receiver
FM022_RS05305	COG0642	Histidine kinase
FM022_RS05340	COG0513	Belongs to the DEAD box helicase family
FM022_RS05350	COG0745	RESPONSE REGULATOR receiver
FM022_RS05385	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FM022_RS05395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FM022_RS05410	COG0521	Mo-molybdopterin cofactor biosynthetic process
FM022_RS05415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FM022_RS05465	COG0243	molybdopterin cofactor binding
FM022_RS05480	COG1193	negative regulation of DNA recombination
FM022_RS05485	COG1253	flavin adenine dinucleotide binding
FM022_RS05495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FM022_RS05500	COG0004	ammonium transporteR
FM022_RS05525	COG0028	Belongs to the TPP enzyme family
FM022_RS05530	COG0440	acetolactate synthase activity
FM022_RS05535	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FM022_RS05540	COG1674	ftsk spoiiie
FM022_RS05540	COG1196	nuclear chromosome segregation
FM022_RS05555	COG3012	SEC-C Motif Domain Protein
FM022_RS05565	COG1160	GTP binding
FM022_RS05570	COG0659	secondary active sulfate transmembrane transporter activity
FM022_RS05600	COG1185	polyribonucleotide nucleotidyltransferase activity
FM022_RS05610	COG2198	Histidine kinase
FM022_RS05610	COG0643	Histidine kinase
FM022_RS05615	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FM022_RS05620	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FM022_RS05625	COG2201	protein-glutamate methylesterase activity
FM022_RS05635	COG2223	nitrite transmembrane transporter activity
FM022_RS05640	COG0582	viral genome integration into host DNA
FM022_RS05660	COG0339	signal peptide processing
FM022_RS05665	COG2890	protein-(glutamine-N5) methyltransferase activity
FM022_RS05670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FM022_RS05675	COG0494	nUDIX hydrolase
FM022_RS05680	COG0527	aspartate kinase activity
FM022_RS05705	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FM022_RS05710	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FM022_RS05715	COG0612	Peptidase, M16
FM022_RS05720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FM022_RS05745	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FM022_RS05755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FM022_RS05755	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FM022_RS05780	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FM022_RS05805	COG0751	glycine-tRNA ligase activity
FM022_RS05820	COG0357	Ribosomal RNA small subunit methyltransferase G
FM022_RS05825	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FM022_RS05830	COG0113	porphobilinogen synthase activity
FM022_RS05840	COG0745	RESPONSE REGULATOR receiver
FM022_RS05855	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FM022_RS05855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FM022_RS05860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FM022_RS05865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FM022_RS05890	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FM022_RS05910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FM022_RS05915	COG0805	protein transport
FM022_RS05920	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FM022_RS05925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FM022_RS05940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FM022_RS05960	COG2181	nitrate reductase activity
FM022_RS05960	COG0247	lactate metabolic process
FM022_RS05965	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FM022_RS05985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FM022_RS05990	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FM022_RS06000	COG1137	ATPase activity
FM022_RS06005	COG0802	atpase or kinase
FM022_RS06010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FM022_RS06025	COG0137	argininosuccinate synthase activity
FM022_RS06030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FM022_RS06035	COG1696	Membrane protein involved in D-alanine export
FM022_RS06045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FM022_RS06055	COG0569	domain protein
FM022_RS06060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FM022_RS06065	COG0745	RESPONSE REGULATOR receiver
FM022_RS06070	COG2205	protein histidine kinase activity
FM022_RS06085	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FM022_RS06090	COG0484	heat shock protein binding
FM022_RS06095	COG0133	tryptophan synthase activity
FM022_RS06115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FM022_RS06125	COG2199	diguanylate cyclase activity
FM022_RS06130	COG0500	methyltransferase
FM022_RS06140	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FM022_RS06140	COG1333	cytochrome c biogenesis protein
FM022_RS06145	COG2195	Cleaves the N-terminal amino acid of tripeptides
FM022_RS06155	COG0840	transmembrane signaling receptor activity
FM022_RS06170	COG0653	protein targeting
FM022_RS06175	COG4591	ABC-type transport system involved in lipoprotein release permease component
FM022_RS06195	COG0039	L-malate dehydrogenase activity
FM022_RS06220	COG0275	rRNA processing
FM022_RS06265	COG3278	Belongs to the heme-copper respiratory oxidase family
FM022_RS06270	COG2207	Transcriptional regulator
FM022_RS06270	COG4753	response regulator
FM022_RS06280	COG1959	2 iron, 2 sulfur cluster binding
FM022_RS06295	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FM022_RS06295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FM022_RS06305	COG2201	protein-glutamate methylesterase activity
FM022_RS06320	COG0484	heat shock protein binding
FM022_RS06325	COG0789	Transcriptional regulator
FM022_RS06330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FM022_RS06335	COG1131	(ABC) transporter
FM022_RS06340	COG0842	Transport permease protein
FM022_RS06345	COG0842	Transport permease protein
FM022_RS06350	COG0861	Integral membrane protein TerC family
FM022_RS06355	COG1114	Component of the transport system for branched-chain amino acids
FM022_RS06375	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FM022_RS06385	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FM022_RS06395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FM022_RS06400	COG4773	Receptor
FM022_RS06410	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FM022_RS06435	COG1393	Belongs to the ArsC family
FM022_RS06475	COG2171	N-acyltransferase activity
FM022_RS06480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FM022_RS06490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FM022_RS06520	COG0309	Hydrogenase expression formation protein (HypE)
FM022_RS06530	COG2084	Dehydrogenase
FM022_RS06535	COG0409	Hydrogenase expression formation protein
FM022_RS06540	COG0298	carbon dioxide binding
FM022_RS06545	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FM022_RS06565	COG2081	HI0933 family
FM022_RS06570	COG2354	Protein conserved in bacteria
FM022_RS06585	COG2814	Major facilitator Superfamily
FM022_RS06595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FM022_RS06595	COG0301	tRNA thio-modification
FM022_RS06615	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FM022_RS06620	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FM022_RS06625	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FM022_RS06630	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
FM022_RS06635	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
FM022_RS06640	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
FM022_RS06655	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FM022_RS06670	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
FM022_RS06675	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
FM022_RS06690	COG1309	transcriptional regulator
FM022_RS06695	COG1049	propionate catabolic process, 2-methylcitrate cycle
FM022_RS06710	COG0217	transcriptional regulatory protein
FM022_RS06715	COG2853	Lipoprotein
FM022_RS06730	COG1611	Belongs to the LOG family
FM022_RS06735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FM022_RS06750	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FM022_RS06800	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FM022_RS06825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FM022_RS06830	COG2258	MOSC domain
FM022_RS06835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FM022_RS06840	COG0095	Lipoate-protein ligase
FM022_RS06845	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FM022_RS06850	COG0508	dehydrogenase complex catalyzes the overall conversion of
FM022_RS06860	COG1492	cobalamin metabolic process
FM022_RS06880	COG0513	Belongs to the DEAD box helicase family
FM022_RS06885	COG1944	ATP diphosphatase activity
FM022_RS06900	COG0840	transmembrane signaling receptor activity
FM022_RS06910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FM022_RS06940	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FM022_RS06950	COG0437	4 iron, 4 sulfur cluster binding
FM022_RS07005	COG1305	Transglutaminase-like
FM022_RS07015	COG0437	4 iron, 4 sulfur cluster binding
FM022_RS07020	COG3383	formate dehydrogenase (NAD+) activity
FM022_RS07020	COG0243	molybdopterin cofactor binding
FM022_RS07030	COG0709	Synthesizes selenophosphate from selenide and ATP
FM022_RS07150	COG1078	dGTPase activity
FM022_RS07160	COG0259	pyridoxamine-phosphate oxidase activity
FM022_RS07170	COG0513	Belongs to the DEAD box helicase family
FM022_RS07190	COG0326	Molecular chaperone. Has ATPase activity
FM022_RS07215	COG2995	paraquat-inducible protein a
FM022_RS07230	COG5002	protein histidine kinase activity
FM022_RS07230	COG5001	Diguanylate cyclase
FM022_RS07260	COG4335	DNA alkylation repair
FM022_RS07290	COG1595	DNA-templated transcription, initiation
FM022_RS07295	COG0010	Belongs to the arginase family
FM022_RS07300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FM022_RS07310	COG0519	Catalyzes the synthesis of GMP from XMP
FM022_RS07315	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FM022_RS07320	COG0668	transmembrane transport
FM022_RS07325	COG1227	inorganic diphosphatase activity
FM022_RS07340	COG1027	Aspartate ammonia-lyase
FM022_RS07345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FM022_RS07350	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FM022_RS07355	COG1047	Peptidyl-prolyl cis-trans
FM022_RS07370	COG0823	Involved in the tonB-independent uptake of proteins
FM022_RS07380	COG0848	biopolymer transport protein
FM022_RS07385	COG0811	peptide transport
FM022_RS07390	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FM022_RS07395	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FM022_RS07400	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FM022_RS07405	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FM022_RS07410	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FM022_RS07425	COG1475	DNA binding
FM022_RS07430	COG1192	Involved in chromosome partitioning
FM022_RS07445	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FM022_RS07450	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FM022_RS07455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FM022_RS07460	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FM022_RS07465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FM022_RS07470	COG0358	DNA primase activity
FM022_RS07480	COG0571	ribonuclease III activity
FM022_RS07485	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FM022_RS07495	COG0501	Belongs to the peptidase M48B family
FM022_RS07515	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FM022_RS07525	COG0706	membrane insertase activity
FM022_RS07530	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FM022_RS07535	COG0594	ribonuclease P activity
FM022_RS07540	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FM022_RS07545	COG0542	response to heat
FM022_RS07550	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FM022_RS07560	COG2326	polyphosphate kinase activity
FM022_RS07570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FM022_RS07575	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FM022_RS07580	COG0179	Fumarylacetoacetate (FAA) hydrolase
FM022_RS07605	COG0138	bifunctional purine biosynthesis protein purh
FM022_RS07610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FM022_RS07620	COG0739	heme binding
FM022_RS07625	COG0302	gtp cyclohydrolase
FM022_RS07630	COG0598	Magnesium transport protein CorA
FM022_RS07655	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FM022_RS07700	COG0840	transmembrane signaling receptor activity
FM022_RS07715	COG0242	peptide deformylase activity
FM022_RS07720	COG0740	serine-type endopeptidase activity
FM022_RS07725	COG0544	peptidyl-prolyl cis-trans isomerase activity
FM022_RS07735	COG2326	polyphosphate kinase activity
FM022_RS07765	COG0626	cystathionine gamma-synthase activity
FM022_RS07780	COG0840	transmembrane signaling receptor activity
FM022_RS07790	COG0784	Response regulator, receiver
FM022_RS07790	COG3437	response regulator, receiver
FM022_RS07795	COG0840	transmembrane signaling receptor activity
FM022_RS07800	COG2205	protein histidine kinase activity
FM022_RS07855	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FM022_RS07860	COG1858	cytochrome C peroxidase
FM022_RS07890	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FM022_RS07915	COG0351	phosphomethylpyrimidine kinase
FM022_RS07920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FM022_RS07945	COG2207	Transcriptional regulator
FM022_RS07945	COG4753	response regulator
FM022_RS07960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FM022_RS07980	COG0716	FMN binding
FM022_RS07995	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FM022_RS08000	COG0159	tryptophan synthase activity
FM022_RS08005	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FM022_RS08015	COG0628	permease
FM022_RS08055	COG0731	radical SAM domain protein
FM022_RS08060	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FM022_RS08070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FM022_RS08085	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FM022_RS08095	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FM022_RS08105	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FM022_RS08115	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FM022_RS08115	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FM022_RS08160	COG0438	transferase activity, transferring glycosyl groups
FM022_RS08185	COG1696	Membrane protein involved in D-alanine export
FM022_RS08195	COG1696	Membrane protein involved in D-alanine export
FM022_RS08260	COG0859	PFAM glycosyl transferase family 9
FM022_RS08270	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FM022_RS08280	COG0493	'glutamate synthase
FM022_RS08285	COG0067	glutamate synthase
FM022_RS08285	COG0070	glutamate synthase
FM022_RS08285	COG0069	glutamate synthase activity
FM022_RS08300	COG0840	transmembrane signaling receptor activity
FM022_RS08305	COG0840	transmembrane signaling receptor activity
FM022_RS08315	COG1739	Uncharacterized protein family UPF0029
FM022_RS08325	COG0196	riboflavin kinase activity
FM022_RS08330	COG2226	methyltransferase
FM022_RS08335	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FM022_RS08350	COG1295	ribonuclease BN
FM022_RS08360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FM022_RS08370	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FM022_RS08375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FM022_RS08380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FM022_RS08385	COG0284	orotidine-5'-phosphate decarboxylase activity
FM022_RS08450	COG1918	ferrous iron import across plasma membrane
FM022_RS08455	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FM022_RS08455	COG1918	ferrous iron import across plasma membrane
FM022_RS08480	COG2217	Heavy metal translocating P-type atpase
FM022_RS08490	COG4773	Receptor
FM022_RS08500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FM022_RS08515	COG1278	Cold shock
FM022_RS08520	COG0745	RESPONSE REGULATOR receiver
FM022_RS08525	COG3852	Histidine kinase
FM022_RS08555	COG3135	benzoate transporter
FM022_RS08570	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FM022_RS08575	COG0085	RNA polymerase activity
FM022_RS08580	COG0222	ribosome binding
FM022_RS08585	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FM022_RS08590	COG0081	regulation of translation
FM022_RS08595	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FM022_RS08600	COG0250	Participates in transcription elongation, termination and antitermination
FM022_RS08615	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FM022_RS08620	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FM022_RS08650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FM022_RS08655	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FM022_RS08660	COG0444	Belongs to the ABC transporter superfamily
FM022_RS08665	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FM022_RS08675	COG1696	Membrane protein involved in D-alanine export
FM022_RS08680	COG0174	glutamine synthetase
FM022_RS08690	COG0314	molybdopterin synthase activity
FM022_RS08700	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FM022_RS08705	COG1968	undecaprenyl-diphosphatase activity
FM022_RS08715	COG0772	Belongs to the SEDS family
FM022_RS08725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FM022_RS08765	COG0542	response to heat
FM022_RS08770	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FM022_RS08790	COG2030	dehydratase
FM022_RS08810	COG0840	transmembrane signaling receptor activity
FM022_RS08815	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FM022_RS08835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FM022_RS08840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FM022_RS08850	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FM022_RS08855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FM022_RS08860	COG1157	protein secretion by the type III secretion system
FM022_RS08870	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FM022_RS08890	COG1677	Flagellar hook-basal body complex protein FliE
FM022_RS08900	COG0455	bacterial-type flagellum organization
FM022_RS08905	COG1419	protein localization to endoplasmic reticulum
FM022_RS08920	COG3951	Flagellar rod assembly protein muramidase FlgJ
FM022_RS08945	COG1749	Flagellar hook protein flgE
FM022_RS08960	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FM022_RS08970	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FM022_RS08975	COG1766	The M ring may be actively involved in energy transduction
FM022_RS08980	COG1815	bacterial-type flagellum-dependent cell motility
FM022_RS08985	COG4786	Flagellar basal body rod
FM022_RS08995	COG0745	RESPONSE REGULATOR receiver
FM022_RS09000	COG4786	Flagellar basal body rod
FM022_RS09015	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FM022_RS09025	COG0228	four-way junction DNA binding
FM022_RS09030	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FM022_RS09035	COG0564	pseudouridine synthase activity
FM022_RS09040	COG1519	Transferase
FM022_RS09050	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FM022_RS09055	COG0752	glycyl-tRNA synthetase alpha subunit
FM022_RS09065	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FM022_RS09075	COG0826	peptidase U32
FM022_RS09080	COG0840	transmembrane signaling receptor activity
FM022_RS09080	COG0840	transmembrane signaling receptor activity
FM022_RS09085	COG0497	DNA recombination
FM022_RS09090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FM022_RS09095	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FM022_RS09100	COG0049	tRNA binding
FM022_RS09105	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FM022_RS09120	COG4771	TonB-dependent receptor
FM022_RS09140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FM022_RS09180	COG0512	Glutamine amidotransferase of anthranilate synthase
FM022_RS09185	COG1840	ABC-type Fe3 transport system, periplasmic component
FM022_RS09190	COG1178	ABC-type Fe3 transport system permease component
FM022_RS09205	COG4774	siderophore transport
FM022_RS09250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FM022_RS09260	COG0251	oxidation-reduction process
FM022_RS09275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FM022_RS09285	COG0586	Pfam SNARE associated Golgi protein
FM022_RS09290	COG0335	large ribosomal subunit rRNA binding
FM022_RS09295	COG0336	Belongs to the RNA methyltransferase TrmD family
FM022_RS09305	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FM022_RS09310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FM022_RS09315	COG0356	it plays a direct role in the translocation of protons across the membrane
FM022_RS09325	COG4773	Receptor
FM022_RS09335	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FM022_RS09345	COG0157	Belongs to the NadC ModD family
FM022_RS09360	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FM022_RS09370	COG0083	homoserine kinase activity
FM022_RS09385	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FM022_RS09390	COG0779	Required for maturation of 30S ribosomal subunits
FM022_RS09395	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FM022_RS09395	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FM022_RS09400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FM022_RS09405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FM022_RS09410	COG0539	negative regulation of cytoplasmic translation
FM022_RS09410	COG1185	polyribonucleotide nucleotidyltransferase activity
FM022_RS09415	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FM022_RS09420	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FM022_RS09425	COG0072	phenylalanine-tRNA ligase activity
FM022_RS09425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FM022_RS09430	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FM022_RS09435	COG0537	adenosine 5'-monophosphoramidase activity
FM022_RS09440	COG0825	malonyl-CoA metabolic process
FM022_RS09445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FM022_RS09450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FM022_RS09460	COG0602	queuosine metabolic process
FM022_RS09470	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FM022_RS09480	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FM022_RS09490	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FM022_RS09500	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FM022_RS09505	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FM022_RS09510	COG1074	ATP-dependent DNA helicase activity
FM022_RS09520	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FM022_RS09565	COG3278	Belongs to the heme-copper respiratory oxidase family
FM022_RS09570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FM022_RS09575	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FM022_RS09580	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FM022_RS09595	COG1242	4 iron, 4 sulfur cluster binding
FM022_RS09600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FM022_RS09605	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FM022_RS09610	COG0492	ferredoxin-NADP+ reductase activity
FM022_RS09615	COG3118	belongs to the thioredoxin family
FM022_RS09620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FM022_RS09645	COG0642	Histidine kinase
FM022_RS09650	COG0745	RESPONSE REGULATOR receiver
FM022_RS09660	COG0129	dihydroxy-acid dehydratase activity
FM022_RS09690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FM022_RS09725	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FM022_RS09730	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FM022_RS09735	COG0047	phosphoribosylformylglycinamidine synthase activity
FM022_RS09745	COG0204	Acyl-transferase
FM022_RS09750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FM022_RS09755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FM022_RS09760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FM022_RS09765	COG0018	arginyl-trna synthetase
FM022_RS09775	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FM022_RS09785	COG0126	phosphoglycerate kinase activity
FM022_RS09795	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FM022_RS09800	COG0019	diaminopimelate decarboxylase activity
FM022_RS09805	COG1605	Chorismate mutase
FM022_RS09805	COG0077	Prephenate dehydratase
FM022_RS09810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FM022_RS09815	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FM022_RS09855	COG0791	NLP P60 protein
FM022_RS09870	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FM022_RS09875	COG1012	belongs to the aldehyde dehydrogenase family
FM022_RS09885	COG1704	LemA family
FM022_RS09900	COG0546	phosphoglycolate phosphatase activity
FM022_RS09920	COG2814	Major facilitator Superfamily
FM022_RS09940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FM022_RS09970	COG2081	HI0933 family
FM022_RS09985	COG1959	2 iron, 2 sulfur cluster binding
FM022_RS10000	COG0175	sulfate reduction
FM022_RS10005	COG0175	sulfate reduction
FM022_RS10010	COG2895	sulfate adenylyltransferase (ATP) activity
FM022_RS10060	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FM022_RS10075	COG4232	protein-disulfide reductase activity
FM022_RS10080	COG0189	ligase activity
FM022_RS10095	COG3287	FIST C domain
FM022_RS10095	COG2200	EAL domain
FM022_RS10095	COG2199	diguanylate cyclase activity
FM022_RS10100	COG0688	phosphatidylethanolamine metabolic process
FM022_RS10110	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FM022_RS10115	COG0443	Heat shock 70 kDa protein
FM022_RS10120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FM022_RS10135	COG0101	tRNA pseudouridine synthase activity
FM022_RS10150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FM022_RS10155	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FM022_RS10160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FM022_RS10175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FM022_RS10180	COG0494	nUDIX hydrolase
FM022_RS10210	COG0445	tRNA wobble uridine modification
FM022_RS10230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FM022_RS10235	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FM022_RS10240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FM022_RS10245	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FM022_RS10250	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FM022_RS10260	COG1252	NADH dehydrogenase
FM022_RS10265	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FM022_RS10290	COG2814	Major facilitator Superfamily
FM022_RS10295	COG0659	secondary active sulfate transmembrane transporter activity
FM022_RS10315	COG1222	aaa ATPase
FM022_RS10325	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FM022_RS10330	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FM022_RS10345	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FM022_RS10360	COG0148	phosphopyruvate hydratase activity
FM022_RS10365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FM022_RS10375	COG1086	Polysaccharide biosynthesis protein
FM022_RS10380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FM022_RS10390	COG2089	acid synthase
FM022_RS10410	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FM022_RS10430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FM022_RS10440	COG0348	domain, Protein
FM022_RS10445	COG0504	CTP synthase activity
FM022_RS10450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FM022_RS10475	COG0587	DNA-directed DNA polymerase activity
FM022_RS10480	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FM022_RS10495	COG0315	cyclic pyranopterin monophosphate synthase activity
FM022_RS10500	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FM022_RS10575	COG3022	response to hydroperoxide
FM022_RS10605	COG0840	transmembrane signaling receptor activity
FM022_RS10625	COG1305	Transglutaminase-like
FM022_RS10635	COG4208	sulfate ABC transporter
FM022_RS10665	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FM022_RS10675	COG1116	anion transmembrane transporter activity
FM022_RS10685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FM022_RS10690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FM022_RS10700	COG1116	anion transmembrane transporter activity
FM022_RS10705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FM022_RS10715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FM022_RS10740	COG2308	Evidence 4 Homologs of previously reported genes of
FM022_RS10745	COG1217	gtp-binding protein TYPA
FM022_RS10750	COG2391	methyltransferase activity
FM022_RS10755	COG0425	Belongs to the sulfur carrier protein TusA family
FM022_RS10790	COG3706	GGDEF domain
FM022_RS10835	COG0745	RESPONSE REGULATOR receiver
FM022_RS10840	COG0642	Histidine kinase
FM022_RS10845	COG2226	methyltransferase
FM022_RS10855	COG3437	response regulator, receiver
FM022_RS10855	COG0784	Response regulator, receiver
FM022_RS10860	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
FM022_RS10880	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group