locus-tag	class	description
ACAN_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACAN_RS00010	COG0592	DNA-directed DNA polymerase activity
ACAN_RS00015	COG0187	DNA topoisomerase II activity
ACAN_RS00040	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACAN_RS00055	COG1238	metal cluster binding
ACAN_RS00065	COG0564	pseudouridine synthase activity
ACAN_RS00070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACAN_RS00075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACAN_RS00080	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACAN_RS00090	COG0778	Nitroreductase
ACAN_RS00095	COG1151	hydroxylamine reductase activity
ACAN_RS00100	COG0493	'glutamate synthase
ACAN_RS00120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACAN_RS00135	COG1858	cytochrome C peroxidase
ACAN_RS00145	COG4753	response regulator
ACAN_RS00145	COG2207	Transcriptional regulator
ACAN_RS00150	COG3852	Histidine kinase
ACAN_RS00155	COG4771	TonB-dependent receptor
ACAN_RS00165	COG0642	Histidine kinase
ACAN_RS00170	COG0745	RESPONSE REGULATOR receiver
ACAN_RS00180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACAN_RS00185	COG0348	domain, Protein
ACAN_RS00190	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACAN_RS00195	COG3118	belongs to the thioredoxin family
ACAN_RS00200	COG1733	regulation of RNA biosynthetic process
ACAN_RS00205	COG0604	alcohol dehydrogenase
ACAN_RS00210	COG1733	regulation of RNA biosynthetic process
ACAN_RS00215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACAN_RS00220	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACAN_RS00235	COG0107	imidazoleglycerol-phosphate synthase activity
ACAN_RS00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACAN_RS00245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ACAN_RS00250	COG0517	IMP dehydrogenase activity
ACAN_RS00250	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ACAN_RS00255	COG1187	pseudouridine synthase activity
ACAN_RS00260	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACAN_RS00260	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ACAN_RS00265	COG1981	membrane
ACAN_RS00270	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ACAN_RS00275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACAN_RS00285	COG0840	transmembrane signaling receptor activity
ACAN_RS00290	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ACAN_RS00295	COG0778	Nitroreductase
ACAN_RS00305	COG0367	asparagine synthase
ACAN_RS00315	COG0306	phosphate transporter
ACAN_RS00325	COG0513	Belongs to the DEAD box helicase family
ACAN_RS00330	COG0439	Biotin carboxylase
ACAN_RS00335	COG0511	ligase activity, forming carbon-carbon bonds
ACAN_RS00350	COG0247	lactate metabolic process
ACAN_RS00355	COG1139	Iron-sulfur cluster binding protein
ACAN_RS00360	COG1556	Lactate utilization protein
ACAN_RS00365	COG3852	Histidine kinase
ACAN_RS00370	COG0745	RESPONSE REGULATOR receiver
ACAN_RS00375	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ACAN_RS00400	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACAN_RS00405	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACAN_RS00415	COG0745	RESPONSE REGULATOR receiver
ACAN_RS00450	COG0390	transport system, permease component
ACAN_RS00455	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACAN_RS00460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACAN_RS00475	COG0642	Histidine kinase
ACAN_RS00480	COG0745	RESPONSE REGULATOR receiver
ACAN_RS00495	COG3220	belongs to the UPF0276 family
ACAN_RS00505	COG4191	Histidine kinase
ACAN_RS00510	COG0745	RESPONSE REGULATOR receiver
ACAN_RS00525	COG0534	Mate efflux family protein
ACAN_RS00530	COG0460	homoserine dehydrogenase
ACAN_RS00535	COG0436	Aminotransferase
ACAN_RS00550	COG0840	transmembrane signaling receptor activity
ACAN_RS00555	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ACAN_RS00560	COG0254	rRNA binding
ACAN_RS00565	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACAN_RS00580	COG2199	diguanylate cyclase activity
ACAN_RS00660	COG2378	regulation of single-species biofilm formation
ACAN_RS00730	COG2239	Acts as a magnesium transporter
ACAN_RS00735	COG5001	Diguanylate cyclase
ACAN_RS00735	COG4251	negative regulation of phosphorylation
ACAN_RS00735	COG3706	GGDEF domain
ACAN_RS00735	COG2203	Gaf domain
ACAN_RS00750	COG0492	ferredoxin-NADP+ reductase activity
ACAN_RS00755	COG0450	alkyl hydroperoxide reductase
ACAN_RS00760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACAN_RS00760	COG4191	Histidine kinase
ACAN_RS00770	COG5002	protein histidine kinase activity
ACAN_RS00770	COG5001	Diguanylate cyclase
ACAN_RS00770	COG3447	MASE1 domain protein
ACAN_RS00775	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ACAN_RS00780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACAN_RS00785	COG0237	dephospho-CoA kinase activity
ACAN_RS00790	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ACAN_RS00795	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACAN_RS00805	COG2353	YceI-like domain
ACAN_RS00810	COG1846	Transcriptional regulator
ACAN_RS00815	COG1280	lysine exporter protein (LysE YggA)
ACAN_RS00825	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ACAN_RS00830	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ACAN_RS00835	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACAN_RS00845	COG0505	Belongs to the CarA family
ACAN_RS00860	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACAN_RS00860	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACAN_RS00870	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACAN_RS00875	COG0489	protein tyrosine kinase activity
ACAN_RS00885	COG0140	phosphoribosyl-ATP diphosphatase activity
ACAN_RS00885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACAN_RS00905	COG0646	methionine synthase
ACAN_RS00905	COG1410	methionine synthase
ACAN_RS00940	COG5001	Diguanylate cyclase
ACAN_RS00940	COG4251	negative regulation of phosphorylation
ACAN_RS00940	COG3706	GGDEF domain
ACAN_RS00940	COG2203	Gaf domain
ACAN_RS00955	COG0277	FAD linked oxidase domain protein
ACAN_RS00965	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACAN_RS00970	COG2226	methyltransferase
ACAN_RS00985	COG1739	Uncharacterized protein family UPF0029
ACAN_RS00990	COG1450	Type ii and iii secretion system protein
ACAN_RS01005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACAN_RS01015	COG0069	glutamate synthase activity
ACAN_RS01035	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACAN_RS01040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACAN_RS01045	COG0284	orotidine-5'-phosphate decarboxylase activity
ACAN_RS01135	COG1854	S-ribosylhomocysteine lyase activity
ACAN_RS01140	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACAN_RS01140	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACAN_RS01140	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACAN_RS01140	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACAN_RS01145	COG0546	phosphoglycolate phosphatase activity
ACAN_RS01150	COG0747	negative chemotaxis
ACAN_RS01155	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACAN_RS01160	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACAN_RS01165	COG3850	Histidine kinase
ACAN_RS01165	COG5002	protein histidine kinase activity
ACAN_RS01170	COG0745	RESPONSE REGULATOR receiver
ACAN_RS01185	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACAN_RS01195	COG0573	inorganic phosphate transmembrane transporter activity
ACAN_RS01200	COG2199	diguanylate cyclase activity
ACAN_RS01200	COG2200	EAL domain
ACAN_RS01200	COG2203	Gaf domain
ACAN_RS01210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACAN_RS01215	COG0268	Binds directly to 16S ribosomal RNA
ACAN_RS01220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACAN_RS01225	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACAN_RS01230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACAN_RS01235	COG0746	molybdenum cofactor guanylyltransferase activity
ACAN_RS01250	COG0243	molybdopterin cofactor binding
ACAN_RS01255	COG0437	4 iron, 4 sulfur cluster binding
ACAN_RS01275	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACAN_RS01280	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACAN_RS01285	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACAN_RS01320	COG0575	Belongs to the CDS family
ACAN_RS01325	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ACAN_RS01345	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACAN_RS01350	COG0023	Translation Initiation Factor
ACAN_RS01355	COG1115	amino acid carrier protein
ACAN_RS01360	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ACAN_RS01360	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACAN_RS01370	COG2022	thiamine diphosphate biosynthetic process
ACAN_RS01425	COG4974	Belongs to the 'phage' integrase family
ACAN_RS01460	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ACAN_RS01465	COG3421	Type III restriction
ACAN_RS01470	COG3586	endonuclease activity
ACAN_RS01570	COG0745	RESPONSE REGULATOR receiver
ACAN_RS01575	COG2203	Gaf domain
ACAN_RS01575	COG4251	negative regulation of phosphorylation
ACAN_RS01575	COG5001	Diguanylate cyclase
ACAN_RS01575	COG3706	GGDEF domain
ACAN_RS01580	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ACAN_RS01585	COG0585	pseudouridine synthase activity
ACAN_RS01595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ACAN_RS01600	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACAN_RS01605	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACAN_RS01620	COG0793	Belongs to the peptidase S41A family
ACAN_RS01625	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ACAN_RS01630	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACAN_RS01635	COG0047	phosphoribosylformylglycinamidine synthase activity
ACAN_RS01645	COG0204	Acyl-transferase
ACAN_RS01650	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACAN_RS01660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACAN_RS01665	COG0018	arginyl-trna synthetase
ACAN_RS01675	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ACAN_RS01685	COG0126	phosphoglycerate kinase activity
ACAN_RS01690	COG0149	triose-phosphate isomerase activity
ACAN_RS01695	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACAN_RS01700	COG0019	diaminopimelate decarboxylase activity
ACAN_RS01705	COG0647	UMP catabolic process
ACAN_RS01710	COG0077	Prephenate dehydratase
ACAN_RS01710	COG1605	Chorismate mutase
ACAN_RS01715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACAN_RS01720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACAN_RS01725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACAN_RS01735	COG0424	maF-like protein
ACAN_RS01760	COG0791	NLP P60 protein
ACAN_RS01770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACAN_RS01775	COG3118	belongs to the thioredoxin family
ACAN_RS01780	COG5002	protein histidine kinase activity
ACAN_RS01785	COG0745	RESPONSE REGULATOR receiver
ACAN_RS01790	COG1115	amino acid carrier protein
ACAN_RS01795	COG0492	ferredoxin-NADP+ reductase activity
ACAN_RS01800	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACAN_RS01805	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ACAN_RS01810	COG1242	4 iron, 4 sulfur cluster binding
ACAN_RS01820	COG0210	DNA helicase
ACAN_RS01825	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACAN_RS01830	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACAN_RS01835	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACAN_RS01840	COG3278	Belongs to the heme-copper respiratory oxidase family
ACAN_RS01880	COG0814	amino acid
ACAN_RS01885	COG4773	Receptor
ACAN_RS01890	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACAN_RS01900	COG4773	Receptor
ACAN_RS01910	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ACAN_RS01920	COG0157	Belongs to the NadC ModD family
ACAN_RS01935	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ACAN_RS01945	COG0083	homoserine kinase activity
ACAN_RS01955	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACAN_RS01960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACAN_RS01965	COG0779	Required for maturation of 30S ribosomal subunits
ACAN_RS01970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACAN_RS01970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACAN_RS01990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACAN_RS01995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACAN_RS02000	COG0539	negative regulation of cytoplasmic translation
ACAN_RS02000	COG1185	polyribonucleotide nucleotidyltransferase activity
ACAN_RS02005	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACAN_RS02010	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACAN_RS02015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACAN_RS02015	COG0072	phenylalanine-tRNA ligase activity
ACAN_RS02020	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACAN_RS02025	COG0537	adenosine 5'-monophosphoramidase activity
ACAN_RS02030	COG0825	malonyl-CoA metabolic process
ACAN_RS02035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACAN_RS02040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACAN_RS02065	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACAN_RS02070	COG0303	'Molybdopterin
ACAN_RS02080	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACAN_RS02095	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ACAN_RS02105	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACAN_RS02110	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACAN_RS02115	COG3706	GGDEF domain
ACAN_RS02120	COG1074	ATP-dependent DNA helicase activity
ACAN_RS02125	COG0840	transmembrane signaling receptor activity
ACAN_RS02130	COG0352	thiamine-phosphate diphosphorylase activity
ACAN_RS02135	COG0840	transmembrane signaling receptor activity
ACAN_RS02140	COG0356	it plays a direct role in the translocation of protons across the membrane
ACAN_RS02145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACAN_RS02150	COG0336	Belongs to the RNA methyltransferase TrmD family
ACAN_RS02155	COG0335	large ribosomal subunit rRNA binding
ACAN_RS02175	COG1028	Short-chain dehydrogenase reductase Sdr
ACAN_RS02185	COG2966	Psort location CytoplasmicMembrane, score
ACAN_RS02200	COG3287	FIST C domain
ACAN_RS02200	COG2200	EAL domain
ACAN_RS02200	COG2199	diguanylate cyclase activity
ACAN_RS02210	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACAN_RS02215	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACAN_RS02255	COG1971	Probably functions as a manganese efflux pump
ACAN_RS02265	COG2814	Major facilitator Superfamily
ACAN_RS02270	COG1132	(ABC) transporter
ACAN_RS02275	COG1132	(ABC) transporter
ACAN_RS02280	COG4771	TonB-dependent receptor
ACAN_RS02290	COG4771	TonB-dependent receptor
ACAN_RS02300	COG1629	transport
ACAN_RS02305	COG0784	Response regulator, receiver
ACAN_RS02325	COG0848	biopolymer transport protein
ACAN_RS02330	COG0811	peptide transport
ACAN_RS02335	COG0811	peptide transport
ACAN_RS02370	COG4774	siderophore transport
ACAN_RS02375	COG1917	Cupin 2, conserved barrel domain protein
ACAN_RS02375	COG2169	Transcriptional regulator
ACAN_RS02385	COG4773	Receptor
ACAN_RS02390	COG2207	Transcriptional regulator
ACAN_RS02390	COG4753	response regulator
ACAN_RS02395	COG3852	Histidine kinase
ACAN_RS02415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACAN_RS02420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACAN_RS02420	COG1333	cytochrome c biogenesis protein
ACAN_RS02425	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ACAN_RS02430	COG3005	denitrification pathway
ACAN_RS02440	COG0840	transmembrane signaling receptor activity
ACAN_RS02460	COG3043	anaerobic respiration
ACAN_RS02465	COG0348	domain, Protein
ACAN_RS02470	COG0437	4 iron, 4 sulfur cluster binding
ACAN_RS02475	COG0243	molybdopterin cofactor binding
ACAN_RS02480	COG1648	precorrin-2 dehydrogenase activity
ACAN_RS02480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACAN_RS02495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACAN_RS02505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACAN_RS02515	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACAN_RS02525	COG2404	hydrolase activity, acting on ester bonds
ACAN_RS02535	COG0579	oxidoreductase
ACAN_RS02550	COG0745	RESPONSE REGULATOR receiver
ACAN_RS02565	COG0753	catalase activity
ACAN_RS02590	COG0642	Histidine kinase
ACAN_RS02595	COG0745	RESPONSE REGULATOR receiver
ACAN_RS02600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACAN_RS02605	COG0191	fructose-bisphosphate aldolase activity
ACAN_RS02610	COG0745	RESPONSE REGULATOR receiver
ACAN_RS02615	COG0642	Histidine kinase
ACAN_RS02625	COG0848	biopolymer transport protein
ACAN_RS02630	COG0811	peptide transport
ACAN_RS02645	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACAN_RS02650	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACAN_RS02660	COG0142	geranyltranstransferase activity
ACAN_RS02665	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACAN_RS02670	COG0442	prolyl-tRNA aminoacylation
ACAN_RS02675	COG0668	transmembrane transport
ACAN_RS02680	COG0617	tRNA 3'-terminal CCA addition
ACAN_RS02695	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ACAN_RS02700	COG1862	Preprotein translocase
ACAN_RS02705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACAN_RS02710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACAN_RS02735	COG0495	leucyl-tRNA aminoacylation
ACAN_RS02745	COG0285	dihydrofolate synthase activity
ACAN_RS02750	COG0739	heme binding
ACAN_RS02780	COG0577	efflux transmembrane transporter activity
ACAN_RS02780	COG1136	(ABC) transporter
ACAN_RS02785	COG0577	efflux transmembrane transporter activity
ACAN_RS02785	COG1136	(ABC) transporter
ACAN_RS02790	COG4771	TonB-dependent receptor
ACAN_RS02810	COG0784	Response regulator, receiver
ACAN_RS02835	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ACAN_RS02855	COG1053	succinate dehydrogenase
ACAN_RS02855	COG3976	FMN-binding domain protein
ACAN_RS02860	COG3852	Histidine kinase
ACAN_RS02865	COG0745	RESPONSE REGULATOR receiver
ACAN_RS02875	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACAN_RS02885	COG0745	RESPONSE REGULATOR receiver
ACAN_RS02890	COG0642	Histidine kinase
ACAN_RS02895	COG2081	HI0933 family
ACAN_RS02900	COG1692	metallophosphoesterase
ACAN_RS02920	COG2226	methyltransferase
ACAN_RS02925	COG1570	exodeoxyribonuclease VII activity
ACAN_RS02930	COG0840	transmembrane signaling receptor activity
ACAN_RS02935	COG0840	transmembrane signaling receptor activity
ACAN_RS02945	COG0745	RESPONSE REGULATOR receiver
ACAN_RS02950	COG2204	response regulator
ACAN_RS02955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACAN_RS02965	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ACAN_RS02970	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACAN_RS02985	COG0459	protein refolding
ACAN_RS03000	COG2076	Multidrug Resistance protein
ACAN_RS03015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACAN_RS03020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACAN_RS03025	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ACAN_RS03030	COG0352	thiamine-phosphate diphosphorylase activity
ACAN_RS03035	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ACAN_RS03050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACAN_RS03055	COG2264	protein methyltransferase activity
ACAN_RS03060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACAN_RS03070	COG3437	response regulator, receiver
ACAN_RS03070	COG0784	Response regulator, receiver
ACAN_RS03085	COG5001	Diguanylate cyclase
ACAN_RS03085	COG4251	negative regulation of phosphorylation
ACAN_RS03085	COG3706	GGDEF domain
ACAN_RS03085	COG2203	Gaf domain
ACAN_RS03090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACAN_RS03095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACAN_RS03095	COG0475	glutathione-regulated potassium exporter activity
ACAN_RS03120	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACAN_RS03130	COG1309	transcriptional regulator
ACAN_RS03135	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACAN_RS03145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACAN_RS03150	COG1090	epimerase
ACAN_RS03155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ACAN_RS03170	COG0481	GTPase activity
ACAN_RS03180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACAN_RS03185	COG0482	sulfurtransferase activity
ACAN_RS03190	COG0482	sulfurtransferase activity
ACAN_RS03195	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACAN_RS03200	COG0006	proline dipeptidase activity
ACAN_RS03205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACAN_RS03210	COG0402	S-adenosylhomocysteine deaminase activity
ACAN_RS03215	COG0616	signal peptide processing
ACAN_RS03220	COG0513	Belongs to the DEAD box helicase family
ACAN_RS03225	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACAN_RS03230	COG0280	phosphate acetyltransferase
ACAN_RS03235	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACAN_RS03240	COG2176	DNA-directed DNA polymerase activity
ACAN_RS03260	COG2176	DNA-directed DNA polymerase activity
ACAN_RS03270	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACAN_RS03280	COG0745	RESPONSE REGULATOR receiver
ACAN_RS03285	COG0642	Histidine kinase
ACAN_RS03355	COG0579	oxidoreductase
ACAN_RS03360	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACAN_RS03375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACAN_RS03400	COG0714	Associated with various cellular activities
ACAN_RS03405	COG0741	lytic transglycosylase activity
ACAN_RS03410	COG0052	Belongs to the universal ribosomal protein uS2 family
ACAN_RS03415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACAN_RS03420	COG1136	(ABC) transporter
ACAN_RS03430	COG0194	GDP metabolic process
ACAN_RS03435	COG5002	protein histidine kinase activity
ACAN_RS03435	COG5001	Diguanylate cyclase
ACAN_RS03440	COG0252	asparaginase activity
ACAN_RS03445	COG2217	Heavy metal translocating P-type atpase
ACAN_RS03460	COG1132	(ABC) transporter
ACAN_RS03465	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACAN_RS03475	COG3437	response regulator, receiver
ACAN_RS03475	COG0784	Response regulator, receiver
ACAN_RS03480	COG1355	regulation of microtubule-based process
ACAN_RS03485	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ACAN_RS03490	COG1121	(ABC) transporter
ACAN_RS03495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACAN_RS03500	COG2996	Protein conserved in bacteria
ACAN_RS03505	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ACAN_RS03515	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACAN_RS03520	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ACAN_RS03525	COG0300	oxidoreductase activity
ACAN_RS03555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACAN_RS03565	COG0210	DNA helicase
ACAN_RS03570	COG2199	diguanylate cyclase activity
ACAN_RS03575	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACAN_RS03645	COG0525	valine-tRNA ligase activity
ACAN_RS03650	COG1733	regulation of RNA biosynthetic process
ACAN_RS03670	COG0745	RESPONSE REGULATOR receiver
ACAN_RS03675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACAN_RS03695	COG2814	Major facilitator Superfamily
ACAN_RS03700	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACAN_RS03720	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ACAN_RS03725	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACAN_RS03730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACAN_RS03745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACAN_RS03760	COG0840	transmembrane signaling receptor activity
ACAN_RS03770	COG2217	Heavy metal translocating P-type atpase
ACAN_RS03790	COG0450	alkyl hydroperoxide reductase
ACAN_RS03795	COG2354	Protein conserved in bacteria
ACAN_RS03810	COG0444	Belongs to the ABC transporter superfamily
ACAN_RS03820	COG0601	transmembrane transport
ACAN_RS03825	COG0747	negative chemotaxis
ACAN_RS03840	COG0840	transmembrane signaling receptor activity
ACAN_RS03845	COG0840	transmembrane signaling receptor activity
ACAN_RS03850	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACAN_RS03880	COG1858	cytochrome C peroxidase
ACAN_RS03885	COG1028	Short-chain dehydrogenase reductase Sdr
ACAN_RS03905	COG2207	Transcriptional regulator
ACAN_RS03905	COG1917	Cupin 2, conserved barrel domain protein
ACAN_RS03915	COG0803	Belongs to the bacterial solute-binding protein 9 family
ACAN_RS03920	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ACAN_RS03955	COG0626	cystathionine gamma-synthase activity
ACAN_RS03960	COG1242	4 iron, 4 sulfur cluster binding
ACAN_RS03965	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ACAN_RS04010	COG2151	metal-sulfur cluster biosynthetic enzyme
ACAN_RS04015	COG2166	iron-sulfur cluster assembly
ACAN_RS04020	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACAN_RS04025	COG0719	Fe-S assembly protein
ACAN_RS04030	COG0396	ATPase activity
ACAN_RS04035	COG0719	Fe-S assembly protein
ACAN_RS04040	COG0765	amino acid transport
ACAN_RS04045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACAN_RS04055	COG2906	2 iron, 2 sulfur cluster binding
ACAN_RS04055	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ACAN_RS04055	COG0822	iron-sulfur transferase activity
ACAN_RS04075	COG0165	Argininosuccinate lyase
ACAN_RS04080	COG0835	chemotaxis
ACAN_RS04080	COG0784	Response regulator, receiver
ACAN_RS04085	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ACAN_RS04090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACAN_RS04095	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACAN_RS04110	COG0556	nucleotide-excision repair
ACAN_RS04125	COG0779	Required for maturation of 30S ribosomal subunits
ACAN_RS04130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ACAN_RS04165	COG0698	ribose 5-phosphate isomerase
ACAN_RS04170	COG0681	Belongs to the peptidase S26 family
ACAN_RS04175	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACAN_RS04185	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ACAN_RS04190	COG0193	aminoacyl-tRNA hydrolase activity
ACAN_RS04205	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACAN_RS04215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACAN_RS04220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACAN_RS04225	COG1758	RNA polymerase activity
ACAN_RS04230	COG0528	UMP kinase activity
ACAN_RS04240	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ACAN_RS04245	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ACAN_RS04250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACAN_RS04260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACAN_RS04265	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACAN_RS04280	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACAN_RS04285	COG0305	Participates in initiation and elongation during chromosome replication
ACAN_RS04295	COG0166	Belongs to the GPI family
ACAN_RS04315	COG1943	Transposase
ACAN_RS04320	COG1793	dna ligase
ACAN_RS04330	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACAN_RS04330	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACAN_RS04335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACAN_RS04345	COG0133	tryptophan synthase activity
ACAN_RS04355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACAN_RS04370	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ACAN_RS04375	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ACAN_RS04385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACAN_RS04395	COG2030	dehydratase
ACAN_RS04400	COG0463	Glycosyl transferase, family 2
ACAN_RS04400	COG1216	Glycosyl transferase, family 2
ACAN_RS04405	COG2089	acid synthase
ACAN_RS04425	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACAN_RS04445	COG0673	inositol 2-dehydrogenase activity
ACAN_RS04450	COG1063	alcohol dehydrogenase
ACAN_RS04485	COG2026	Addiction module toxin, RelE StbE family
ACAN_RS04490	COG2161	toxin-antitoxin pair type II binding
ACAN_RS04495	COG4115	mRNA cleavage
ACAN_RS04500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACAN_RS04505	COG1086	Polysaccharide biosynthesis protein
ACAN_RS04530	COG3123	guanosine phosphorylase activity
ACAN_RS04550	COG4139	cobalamin transport
ACAN_RS04555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACAN_RS04560	COG4974	Belongs to the 'phage' integrase family
ACAN_RS04570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACAN_RS04590	COG1475	DNA binding
ACAN_RS04615	COG3620	sequence-specific DNA binding
ACAN_RS04645	COG0582	viral genome integration into host DNA
ACAN_RS04810	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ACAN_RS04815	COG0585	pseudouridine synthase activity
ACAN_RS04825	COG0840	transmembrane signaling receptor activity
ACAN_RS04830	COG0632	four-way junction helicase activity
ACAN_RS04835	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACAN_RS04845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ACAN_RS04865	COG0581	inorganic phosphate transmembrane transporter activity
ACAN_RS04870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACAN_RS04880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACAN_RS04895	COG0051	transcription antitermination factor activity, RNA binding
ACAN_RS04900	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACAN_RS04905	COG0088	Forms part of the polypeptide exit tunnel
ACAN_RS04910	COG0089	rRNA binding
ACAN_RS04915	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACAN_RS04920	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACAN_RS04925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACAN_RS04930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACAN_RS04935	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACAN_RS04940	COG0255	Belongs to the universal ribosomal protein uL29 family
ACAN_RS04945	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACAN_RS04950	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACAN_RS04955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACAN_RS04960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACAN_RS04965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACAN_RS04970	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACAN_RS04975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACAN_RS04985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACAN_RS04990	COG0200	Binds to the 23S rRNA
ACAN_RS04995	COG0201	protein transport
ACAN_RS05000	COG0024	Methionine aminopeptidase
ACAN_RS05005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACAN_RS05020	COG1573	uracil-dna glycosylase
ACAN_RS05030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACAN_RS05045	COG1032	radical SAM domain protein
ACAN_RS05055	COG0563	adenylate kinase activity
ACAN_RS05070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACAN_RS05075	COG0322	excinuclease ABC activity
ACAN_RS05090	COG3201	nicotinamide mononucleotide transporter
ACAN_RS05110	COG0484	heat shock protein binding
ACAN_RS05115	COG1620	l-lactate permease
ACAN_RS05120	COG0840	transmembrane signaling receptor activity
ACAN_RS05125	COG0484	heat shock protein binding
ACAN_RS05140	COG0724	RNA recognition motif
ACAN_RS05145	COG0708	Exodeoxyribonuclease III
ACAN_RS05170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACAN_RS05175	COG0765	amino acid transport
ACAN_RS05190	COG1528	Iron-storage protein
ACAN_RS05195	COG1227	inorganic diphosphatase activity
ACAN_RS05205	COG0010	Belongs to the arginase family
ACAN_RS05250	COG0702	epimerase
ACAN_RS05275	COG0326	Molecular chaperone. Has ATPase activity
ACAN_RS05295	COG0583	DNA-binding transcription factor activity
ACAN_RS05305	COG1566	PFAM secretion protein HlyD family protein
ACAN_RS05325	COG1846	Transcriptional regulator
ACAN_RS05350	COG0840	transmembrane signaling receptor activity
ACAN_RS05355	COG0840	transmembrane signaling receptor activity
ACAN_RS05360	COG2207	Transcriptional regulator
ACAN_RS05360	COG4753	response regulator
ACAN_RS05365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACAN_RS05380	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ACAN_RS05390	COG1984	allophanate hydrolase subunit 2
ACAN_RS05415	COG2183	response to ionizing radiation
ACAN_RS05425	COG2890	protein-(glutamine-N5) methyltransferase activity
ACAN_RS05435	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
ACAN_RS05450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACAN_RS05465	COG0492	ferredoxin-NADP+ reductase activity
ACAN_RS05470	COG0475	glutathione-regulated potassium exporter activity
ACAN_RS05470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACAN_RS05480	COG0693	protein deglycase activity
ACAN_RS05490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ACAN_RS05505	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ACAN_RS05510	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ACAN_RS05520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACAN_RS05530	COG0439	Biotin carboxylase
ACAN_RS05535	COG0288	reversible hydration of carbon dioxide
ACAN_RS05615	COG0784	Response regulator, receiver
ACAN_RS05615	COG5002	protein histidine kinase activity
ACAN_RS05620	COG3437	response regulator, receiver
ACAN_RS05620	COG3850	Histidine kinase
ACAN_RS05620	COG4999	Histidine kinase
ACAN_RS05620	COG2205	protein histidine kinase activity
ACAN_RS05630	COG0745	RESPONSE REGULATOR receiver
ACAN_RS05635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACAN_RS05640	COG0745	RESPONSE REGULATOR receiver
ACAN_RS05645	COG3287	FIST C domain
ACAN_RS05645	COG2199	diguanylate cyclase activity
ACAN_RS05645	COG2200	EAL domain
ACAN_RS05670	COG0739	heme binding
ACAN_RS05675	COG0217	transcriptional regulatory protein
ACAN_RS05700	COG1960	acyl-CoA dehydrogenase activity
ACAN_RS05705	COG1049	propionate catabolic process, 2-methylcitrate cycle
ACAN_RS05715	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ACAN_RS05725	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ACAN_RS05730	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ACAN_RS05735	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
ACAN_RS05740	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ACAN_RS05750	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ACAN_RS05755	COG0733	neurotransmitter:sodium symporter activity
ACAN_RS05760	COG2814	Major facilitator Superfamily
ACAN_RS05765	COG0840	transmembrane signaling receptor activity
ACAN_RS05775	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ACAN_RS05780	COG0298	carbon dioxide binding
ACAN_RS05785	COG0409	Hydrogenase expression formation protein
ACAN_RS05790	COG0309	Hydrogenase expression formation protein (HypE)
ACAN_RS05795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACAN_RS05795	COG1024	Enoyl-CoA hydratase
ACAN_RS05800	COG0375	protein maturation
ACAN_RS05805	COG3706	GGDEF domain
ACAN_RS05815	COG1648	precorrin-2 dehydrogenase activity
ACAN_RS05815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACAN_RS05835	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACAN_RS05840	COG2171	N-acyltransferase activity
ACAN_RS05845	COG1047	Peptidyl-prolyl cis-trans
ACAN_RS05865	COG2884	Cell division ATP-binding protein ftsE
ACAN_RS05870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ACAN_RS05880	COG0564	pseudouridine synthase activity
ACAN_RS05885	COG0772	Belongs to the SEDS family
ACAN_RS05895	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACAN_RS05915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACAN_RS05920	COG0066	3-isopropylmalate dehydratase activity
ACAN_RS05925	COG0473	3-isopropylmalate dehydrogenase activity
ACAN_RS05940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACAN_RS05950	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ACAN_RS05955	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACAN_RS05960	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACAN_RS05965	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACAN_RS05970	COG0202	RNA polymerase activity
ACAN_RS05975	COG0203	ribosomal protein L17
ACAN_RS05980	COG0154	amidase activity
ACAN_RS05985	COG0516	GMP reductase activity
ACAN_RS05985	COG0517	IMP dehydrogenase activity
ACAN_RS06000	COG0456	acetyltransferase
ACAN_RS06065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACAN_RS06075	COG2003	Belongs to the UPF0758 family
ACAN_RS06095	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ACAN_RS06100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACAN_RS06105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACAN_RS06130	COG0420	3'-5' exonuclease activity
ACAN_RS06135	COG0419	ATPase involved in DNA repair
ACAN_RS06180	COG2084	Dehydrogenase
ACAN_RS06190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACAN_RS06195	COG0251	oxidation-reduction process
ACAN_RS06200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACAN_RS06205	COG1879	ABC-type sugar transport system periplasmic component
ACAN_RS06215	COG1846	Transcriptional regulator
ACAN_RS06235	COG1309	transcriptional regulator
ACAN_RS06240	COG0745	RESPONSE REGULATOR receiver
ACAN_RS06245	COG0745	RESPONSE REGULATOR receiver
ACAN_RS06250	COG0745	RESPONSE REGULATOR receiver
ACAN_RS06255	COG2198	Histidine kinase
ACAN_RS06255	COG0643	Histidine kinase
ACAN_RS06265	COG0835	chemotaxis
ACAN_RS06270	COG2201	protein-glutamate methylesterase activity
ACAN_RS06280	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACAN_RS06295	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACAN_RS06305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACAN_RS06310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACAN_RS06320	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACAN_RS06325	COG0471	metal ion transport
ACAN_RS06330	COG1193	negative regulation of DNA recombination
ACAN_RS06345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACAN_RS06365	COG0454	-acetyltransferase
ACAN_RS06380	COG1742	UPF0060 membrane protein
ACAN_RS06395	COG2258	MOSC domain
ACAN_RS06400	COG2824	Alkylphosphonate utilization operon protein PhnA
ACAN_RS06405	COG2207	Transcriptional regulator
ACAN_RS06440	COG1733	regulation of RNA biosynthetic process
ACAN_RS06445	COG2249	NAD(P)H dehydrogenase (quinone) activity
ACAN_RS06455	COG0778	Nitroreductase
ACAN_RS06465	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
ACAN_RS06470	COG0840	transmembrane signaling receptor activity
ACAN_RS06475	COG0840	transmembrane signaling receptor activity
ACAN_RS06480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACAN_RS06510	COG3046	protein related to deoxyribodipyrimidine photolyase
ACAN_RS06515	COG2200	EAL domain
ACAN_RS06520	COG0352	thiamine-phosphate diphosphorylase activity
ACAN_RS06525	COG0157	Belongs to the NadC ModD family
ACAN_RS06535	COG3842	ATPase activity
ACAN_RS06565	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACAN_RS06575	COG0488	(ABC) transporter
ACAN_RS06580	COG1607	acyl-coa hydrolase
ACAN_RS06585	COG1607	acyl-coa hydrolase
ACAN_RS06590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACAN_RS06595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACAN_RS06600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACAN_RS06605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACAN_RS06615	COG0114	fumarate hydratase activity
ACAN_RS06635	COG2030	dehydratase
ACAN_RS06640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACAN_RS06655	COG2195	Cleaves the N-terminal amino acid of tripeptides
ACAN_RS06660	COG3287	FIST C domain
ACAN_RS06660	COG2200	EAL domain
ACAN_RS06660	COG2199	diguanylate cyclase activity
ACAN_RS06665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACAN_RS06665	COG1333	cytochrome c biogenesis protein
ACAN_RS06670	COG0500	methyltransferase
ACAN_RS06675	COG5001	Diguanylate cyclase
ACAN_RS06675	COG4251	negative regulation of phosphorylation
ACAN_RS06675	COG3706	GGDEF domain
ACAN_RS06675	COG2203	Gaf domain
ACAN_RS06690	COG2833	Protein of unknown function (DUF455)
ACAN_RS06695	COG0133	tryptophan synthase activity
ACAN_RS06700	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ACAN_RS06705	COG0484	heat shock protein binding
ACAN_RS06715	COG0840	transmembrane signaling receptor activity
ACAN_RS06720	COG0840	transmembrane signaling receptor activity
ACAN_RS06740	COG3153	acetyltransferase
ACAN_RS06740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACAN_RS06755	COG0745	RESPONSE REGULATOR receiver
ACAN_RS06765	COG2207	Transcriptional regulator
ACAN_RS06765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACAN_RS06810	COG0840	transmembrane signaling receptor activity
ACAN_RS06820	COG0642	Histidine kinase
ACAN_RS06830	COG1794	racemase activity, acting on amino acids and derivatives
ACAN_RS06875	COG0137	argininosuccinate synthase activity
ACAN_RS06885	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACAN_RS06890	COG0802	atpase or kinase
ACAN_RS06895	COG1137	ATPase activity
ACAN_RS06900	COG3706	GGDEF domain
ACAN_RS06905	COG5001	Diguanylate cyclase
ACAN_RS06905	COG5002	protein histidine kinase activity
ACAN_RS06910	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ACAN_RS06920	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACAN_RS06920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACAN_RS06925	COG0745	RESPONSE REGULATOR receiver
ACAN_RS06940	COG0840	transmembrane signaling receptor activity
ACAN_RS06945	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACAN_RS06955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACAN_RS06960	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACAN_RS06985	COG0189	ligase activity
ACAN_RS07005	COG0113	porphobilinogen synthase activity
ACAN_RS07010	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACAN_RS07015	COG0357	Ribosomal RNA small subunit methyltransferase G
ACAN_RS07065	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ACAN_RS07070	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ACAN_RS07080	COG3630	sodium ion export across plasma membrane
ACAN_RS07095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACAN_RS07095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACAN_RS07105	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ACAN_RS07130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACAN_RS07135	COG0612	Peptidase, M16
ACAN_RS07140	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACAN_RS07145	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACAN_RS07150	COG0287	Prephenate dehydrogenase
ACAN_RS07155	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACAN_RS07170	COG0527	aspartate kinase activity
ACAN_RS07175	COG0494	nUDIX hydrolase
ACAN_RS07180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACAN_RS07185	COG2890	protein-(glutamine-N5) methyltransferase activity
ACAN_RS07190	COG0339	signal peptide processing
ACAN_RS07275	COG0515	serine threonine protein kinase
ACAN_RS07275	COG2815	serine threonine protein kinase
ACAN_RS07310	COG0582	viral genome integration into host DNA
ACAN_RS07315	COG2201	protein-glutamate methylesterase activity
ACAN_RS07320	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ACAN_RS07325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACAN_RS07340	COG1185	polyribonucleotide nucleotidyltransferase activity
ACAN_RS07350	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ACAN_RS07370	COG1160	GTP binding
ACAN_RS07380	COG1196	nuclear chromosome segregation
ACAN_RS07380	COG1674	ftsk spoiiie
ACAN_RS07385	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACAN_RS07390	COG0440	acetolactate synthase activity
ACAN_RS07395	COG0028	Belongs to the TPP enzyme family
ACAN_RS07400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ACAN_RS07405	COG0248	Ppx GppA phosphatase
ACAN_RS07415	COG2203	Gaf domain
ACAN_RS07415	COG3706	GGDEF domain
ACAN_RS07415	COG4251	negative regulation of phosphorylation
ACAN_RS07415	COG5001	Diguanylate cyclase
ACAN_RS07430	COG3118	belongs to the thioredoxin family
ACAN_RS07440	COG1683	Conserved Protein
ACAN_RS07445	COG0037	tRNA processing
ACAN_RS07450	COG2056	Na+-H+ antiporter family
ACAN_RS07460	COG4067	protein conserved in archaea
ACAN_RS07460	COG0189	ligase activity
ACAN_RS07475	COG1012	belongs to the aldehyde dehydrogenase family
ACAN_RS07480	COG0410	ABC transporter
ACAN_RS07520	COG0745	RESPONSE REGULATOR receiver
ACAN_RS07530	COG0303	'Molybdopterin
ACAN_RS07545	COG1322	Protein conserved in bacteria
ACAN_RS07550	COG0501	Belongs to the peptidase M48B family
ACAN_RS07560	COG5002	protein histidine kinase activity
ACAN_RS07565	COG0824	Thioesterase
ACAN_RS07580	COG0667	Aldo Keto reductase
ACAN_RS07595	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ACAN_RS07600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACAN_RS07610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACAN_RS07615	COG4206	TonB-dependent receptor
ACAN_RS07625	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ACAN_RS07645	COG1797	cobyrinic acid a,c-diamide synthase activity
ACAN_RS07660	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
ACAN_RS07700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACAN_RS07710	COG0546	phosphoglycolate phosphatase activity
ACAN_RS07730	COG0848	biopolymer transport protein
ACAN_RS07735	COG0811	peptide transport
ACAN_RS07740	COG0642	Histidine kinase
ACAN_RS07745	COG0745	RESPONSE REGULATOR receiver
ACAN_RS07765	COG0788	formyltetrahydrofolate deformylase activity
ACAN_RS07770	COG0281	malic enzyme
ACAN_RS07770	COG0280	phosphate acetyltransferase
ACAN_RS07775	COG1496	oxidoreductase activity
ACAN_RS07780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACAN_RS07800	COG0301	tRNA thio-modification
ACAN_RS07800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACAN_RS07810	COG0754	glutathionylspermidine amidase activity
ACAN_RS07820	COG1663	tetraacyldisaccharide 4'-kinase activity
ACAN_RS07825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACAN_RS07830	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACAN_RS07850	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACAN_RS07855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACAN_RS07860	COG0805	protein transport
ACAN_RS07865	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ACAN_RS07870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ACAN_RS07875	COG0733	neurotransmitter:sodium symporter activity
ACAN_RS07910	COG4865	methylaspartate mutase activity
ACAN_RS07925	COG2863	cytochrome
ACAN_RS07930	COG2199	diguanylate cyclase activity
ACAN_RS07955	COG0275	rRNA processing
ACAN_RS07965	COG0776	regulation of translation
ACAN_RS07990	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACAN_RS08000	COG0456	acetyltransferase
ACAN_RS08005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACAN_RS08010	COG1917	Cupin 2, conserved barrel domain protein
ACAN_RS08020	COG0527	aspartate kinase activity
ACAN_RS08040	COG2863	cytochrome
ACAN_RS08050	COG0642	Histidine kinase
ACAN_RS08055	COG0745	RESPONSE REGULATOR receiver
ACAN_RS08140	COG3287	FIST C domain
ACAN_RS08140	COG2200	EAL domain
ACAN_RS08140	COG2199	diguanylate cyclase activity
ACAN_RS08145	COG0840	transmembrane signaling receptor activity
ACAN_RS08145	COG0840	transmembrane signaling receptor activity
ACAN_RS08150	COG1132	(ABC) transporter
ACAN_RS08155	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ACAN_RS08175	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ACAN_RS08180	COG0653	protein targeting
ACAN_RS08195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACAN_RS08210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACAN_RS08210	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ACAN_RS08220	COG2201	protein-glutamate methylesterase activity
ACAN_RS08235	COG0484	heat shock protein binding
ACAN_RS08240	COG0789	Transcriptional regulator
ACAN_RS08245	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACAN_RS08250	COG0849	cell division
ACAN_RS08260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACAN_RS08285	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACAN_RS08295	COG0768	penicillin binding
ACAN_RS08300	COG1338	Plays a role in the flagellum-specific transport system
ACAN_RS08325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACAN_RS08330	COG0456	acetyltransferase
ACAN_RS08335	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACAN_RS08350	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACAN_RS08355	COG0131	Imidazoleglycerol-phosphate dehydratase
ACAN_RS08360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACAN_RS08370	COG0084	hydrolase, TatD family'
ACAN_RS08385	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ACAN_RS08390	COG0359	binds to the 23S rRNA
ACAN_RS08400	COG0163	prenyltransferase activity
ACAN_RS08405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACAN_RS08410	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACAN_RS08415	COG0124	histidyl-tRNA synthetase
ACAN_RS08420	COG1166	arginine decarboxylase activity
ACAN_RS08425	COG1045	serine acetyltransferase
ACAN_RS08435	COG1473	amidohydrolase
ACAN_RS08440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACAN_RS08445	COG1012	belongs to the aldehyde dehydrogenase family
ACAN_RS08450	COG0006	proline dipeptidase activity
ACAN_RS08455	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACAN_RS08465	COG1301	dicarboxylic acid transport
ACAN_RS08475	COG4536	flavin adenine dinucleotide binding
ACAN_RS08480	COG0748	coenzyme F420 binding
ACAN_RS08490	COG0259	pyridoxamine-phosphate oxidase activity
ACAN_RS08495	COG0386	Belongs to the glutathione peroxidase family
ACAN_RS08530	COG2011	ABC-type metal ion transport system permease component
ACAN_RS08535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACAN_RS08540	COG2223	nitrite transmembrane transporter activity
ACAN_RS08545	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ACAN_RS08550	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ACAN_RS08555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACAN_RS08570	COG0659	secondary active sulfate transmembrane transporter activity
ACAN_RS08580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACAN_RS08590	COG2264	protein methyltransferase activity
ACAN_RS08600	COG1489	DNA binding
ACAN_RS08615	COG2133	pyrroloquinoline quinone binding
ACAN_RS08620	COG1643	Atp-dependent helicase
ACAN_RS08625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACAN_RS08655	COG2226	methyltransferase
ACAN_RS08655	COG0596	Alpha beta hydrolase
ACAN_RS08655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACAN_RS08675	COG1278	Cold shock
ACAN_RS08690	COG0513	Belongs to the DEAD box helicase family
ACAN_RS08775	COG0519	Catalyzes the synthesis of GMP from XMP
ACAN_RS08775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACAN_RS08790	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACAN_RS08810	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ACAN_RS08820	COG0840	transmembrane signaling receptor activity
ACAN_RS08825	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACAN_RS08835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACAN_RS08840	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACAN_RS08845	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ACAN_RS08850	COG0095	Lipoate-protein ligase
ACAN_RS08855	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACAN_RS08860	COG0039	L-malate dehydrogenase activity
ACAN_RS08865	COG0488	(ABC) transporter
ACAN_RS08870	COG1610	YqeY-like protein
ACAN_RS08885	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ACAN_RS08895	COG1136	(ABC) transporter
ACAN_RS08910	COG1320	monovalent cation:proton antiporter activity
ACAN_RS08915	COG2212	antiporter activity
ACAN_RS08920	COG1863	multisubunit Na H antiporter MnhE subunit
ACAN_RS08925	COG0651	ATP synthesis coupled electron transport
ACAN_RS08930	COG1006	Multisubunit Na H antiporter MnhC subunit
ACAN_RS08935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACAN_RS08935	COG2111	Na H antiporter
ACAN_RS08940	COG0300	oxidoreductase activity
ACAN_RS08945	COG1757	Na H antiporter
ACAN_RS08950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACAN_RS08955	COG0742	ribosomal rna small subunit methyltransferase
ACAN_RS08960	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACAN_RS08965	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ACAN_RS08975	COG1418	mRNA catabolic process
ACAN_RS08985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACAN_RS08990	COG0552	protein localization to endoplasmic reticulum
ACAN_RS09005	COG5002	protein histidine kinase activity
ACAN_RS09010	COG3258	Cytochrome c
ACAN_RS09015	COG3150	esterase
ACAN_RS09035	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ACAN_RS09050	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACAN_RS09060	COG0735	belongs to the Fur family
ACAN_RS09065	COG0783	Belongs to the Dps family
ACAN_RS09070	COG1592	Rubrerythrin
ACAN_RS09085	COG0728	peptidoglycan biosynthetic process
ACAN_RS09090	COG1132	(ABC) transporter
ACAN_RS09095	COG0167	dihydroorotate dehydrogenase activity
ACAN_RS09105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACAN_RS09110	COG1028	Short-chain dehydrogenase reductase Sdr
ACAN_RS09115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACAN_RS09120	COG0750	zinc metalloprotease
ACAN_RS09125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ACAN_RS09145	COG0189	ligase activity
ACAN_RS09150	COG0134	indole-3-glycerol-phosphate synthase activity
ACAN_RS09160	COG0727	PFAM Uncharacterised protein family (UPF0153)
ACAN_RS09165	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ACAN_RS09175	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACAN_RS09175	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACAN_RS09180	COG0028	Belongs to the TPP enzyme family
ACAN_RS09200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACAN_RS09205	COG2176	DNA-directed DNA polymerase activity
ACAN_RS09210	COG0135	phosphoribosylanthranilate isomerase activity
ACAN_RS09215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACAN_RS09220	COG3008	intermembrane lipid transfer
ACAN_RS09225	COG2995	paraquat-inducible protein a
ACAN_RS09230	COG2995	paraquat-inducible protein a
ACAN_RS09235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACAN_RS09280	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ACAN_RS09290	COG3706	GGDEF domain
ACAN_RS09295	COG0666	response to abiotic stimulus
ACAN_RS09315	COG0642	Histidine kinase
ACAN_RS09320	COG0745	RESPONSE REGULATOR receiver
ACAN_RS09325	COG2855	membrane
ACAN_RS09330	COG0583	DNA-binding transcription factor activity
ACAN_RS09340	COG1666	GTP binding
ACAN_RS09360	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ACAN_RS09370	COG2363	Small membrane protein
ACAN_RS09380	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ACAN_RS09385	COG2252	PERMEase
ACAN_RS09395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACAN_RS09400	COG4977	sequence-specific DNA binding
ACAN_RS09405	COG3437	response regulator, receiver
ACAN_RS09405	COG0784	Response regulator, receiver
ACAN_RS09410	COG0640	Transcriptional regulator
ACAN_RS09415	COG2217	Heavy metal translocating P-type atpase
ACAN_RS09435	COG1979	alcohol dehydrogenase
ACAN_RS09445	COG1918	ferrous iron import across plasma membrane
ACAN_RS09450	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ACAN_RS09450	COG1918	ferrous iron import across plasma membrane
ACAN_RS09480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACAN_RS09580	COG4695	Portal protein
ACAN_RS09720	COG0731	radical SAM domain protein
ACAN_RS09725	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACAN_RS09735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ACAN_RS09750	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ACAN_RS09760	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACAN_RS09770	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ACAN_RS09775	COG0859	PFAM glycosyl transferase family 9
ACAN_RS09785	COG0515	serine threonine protein kinase
ACAN_RS09790	COG0859	PFAM glycosyl transferase family 9
ACAN_RS09800	COG2194	sulfuric ester hydrolase activity
ACAN_RS09810	COG0297	glycogen (starch) synthase activity
ACAN_RS09815	COG0463	Glycosyl transferase, family 2
ACAN_RS09850	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ACAN_RS09860	COG0859	PFAM glycosyl transferase family 9
ACAN_RS09870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACAN_RS09880	COG0493	'glutamate synthase
ACAN_RS09885	COG0067	glutamate synthase
ACAN_RS09885	COG0069	glutamate synthase activity
ACAN_RS09885	COG0070	glutamate synthase
ACAN_RS09925	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACAN_RS09940	COG1942	4-Oxalocrotonate Tautomerase
ACAN_RS09975	COG1472	Belongs to the glycosyl hydrolase 3 family
ACAN_RS09990	COG2116	formate transmembrane transporter activity
ACAN_RS10005	COG3260	NADH ubiquinone oxidoreductase 20
ACAN_RS10015	COG3261	NADH dehydrogenase
ACAN_RS10015	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ACAN_RS10020	COG0651	ATP synthesis coupled electron transport
ACAN_RS10025	COG4237	Hydrogenase 4 membrane
ACAN_RS10030	COG0650	Formate hydrogenlyase subunit 4
ACAN_RS10035	COG0651	ATP synthesis coupled electron transport
ACAN_RS10040	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACAN_RS10045	COG3383	formate dehydrogenase (NAD+) activity
ACAN_RS10050	COG3383	formate dehydrogenase (NAD+) activity
ACAN_RS10065	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ACAN_RS10070	COG3842	ATPase activity
ACAN_RS10075	COG0725	ABC transporter, periplasmic molybdate-binding protein
ACAN_RS10085	COG4662	Binding-protein-dependent transport system inner membrane component
ACAN_RS10090	COG2998	abc-type tungstate transport system, permease component
ACAN_RS10095	COG0303	'Molybdopterin
ACAN_RS10100	COG1104	cysteine desulfurase activity
ACAN_RS10115	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ACAN_RS10125	COG0437	4 iron, 4 sulfur cluster binding
ACAN_RS10160	COG2204	response regulator
ACAN_RS10175	COG1305	Transglutaminase-like
ACAN_RS10180	COG0709	Synthesizes selenophosphate from selenide and ATP
ACAN_RS10190	COG1921	L-seryl-tRNASec selenium transferase activity
ACAN_RS10205	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ACAN_RS10220	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ACAN_RS10225	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ACAN_RS10230	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACAN_RS10240	COG0840	transmembrane signaling receptor activity
ACAN_RS10245	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACAN_RS10255	COG0513	Belongs to the DEAD box helicase family
ACAN_RS10260	COG0840	transmembrane signaling receptor activity
ACAN_RS10265	COG0419	ATPase involved in DNA repair
ACAN_RS10305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACAN_RS10310	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ACAN_RS10315	COG1047	Peptidyl-prolyl cis-trans
ACAN_RS10330	COG0823	Involved in the tonB-independent uptake of proteins
ACAN_RS10340	COG0848	biopolymer transport protein
ACAN_RS10345	COG0811	peptide transport
ACAN_RS10350	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACAN_RS10355	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACAN_RS10360	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACAN_RS10365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACAN_RS10370	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACAN_RS10375	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ACAN_RS10385	COG1475	DNA binding
ACAN_RS10390	COG1192	Involved in chromosome partitioning
ACAN_RS10410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACAN_RS10415	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACAN_RS10420	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACAN_RS10425	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACAN_RS10430	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACAN_RS10435	COG0251	oxidation-reduction process
ACAN_RS10440	COG0358	DNA primase activity
ACAN_RS10450	COG0328	RNA-DNA hybrid ribonuclease activity
ACAN_RS10455	COG0571	ribonuclease III activity
ACAN_RS10460	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACAN_RS10470	COG1342	Belongs to the UPF0251 family
ACAN_RS10475	COG0501	Belongs to the peptidase M48B family
ACAN_RS10490	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACAN_RS10500	COG0706	membrane insertase activity
ACAN_RS10505	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACAN_RS10515	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ACAN_RS10525	COG0542	response to heat
ACAN_RS10540	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACAN_RS10555	COG5002	protein histidine kinase activity
ACAN_RS10555	COG5001	Diguanylate cyclase
ACAN_RS10565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACAN_RS10565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACAN_RS10570	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACAN_RS10580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACAN_RS10595	COG2610	gluconate transmembrane transporter activity
ACAN_RS10605	COG3118	belongs to the thioredoxin family
ACAN_RS10610	COG0450	alkyl hydroperoxide reductase
ACAN_RS10615	COG0028	Belongs to the TPP enzyme family
ACAN_RS10645	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACAN_RS10655	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ACAN_RS10670	COG0138	bifunctional purine biosynthesis protein purh
ACAN_RS10675	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACAN_RS10685	COG0739	heme binding
ACAN_RS10685	COG1196	nuclear chromosome segregation
ACAN_RS10685	COG0741	lytic transglycosylase activity
ACAN_RS10690	COG2239	Acts as a magnesium transporter
ACAN_RS10700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACAN_RS10715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACAN_RS10730	COG0415	Belongs to the DNA photolyase family
ACAN_RS10750	COG0351	phosphomethylpyrimidine kinase
ACAN_RS10755	COG3279	Response regulator of the LytR AlgR family
ACAN_RS10760	COG3275	phosphorelay sensor kinase activity
ACAN_RS10770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACAN_RS10780	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACAN_RS10785	COG0606	chelatase, subunit chli
ACAN_RS10795	COG0840	transmembrane signaling receptor activity
ACAN_RS10805	COG0242	peptide deformylase activity
ACAN_RS10810	COG0740	serine-type endopeptidase activity
ACAN_RS10815	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACAN_RS10835	COG2326	polyphosphate kinase activity
ACAN_RS10850	COG1773	rubredoxin
ACAN_RS10880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACAN_RS10890	COG0840	transmembrane signaling receptor activity
ACAN_RS10900	COG0668	transmembrane transport
ACAN_RS10915	COG1271	oxidase subunit
ACAN_RS10925	COG1342	Belongs to the UPF0251 family
ACAN_RS10965	COG0716	FMN binding
ACAN_RS10970	COG0716	FMN binding
ACAN_RS10975	COG0716	FMN binding
ACAN_RS11020	COG3706	GGDEF domain
ACAN_RS11030	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ACAN_RS11055	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ACAN_RS11060	COG0159	tryptophan synthase activity
ACAN_RS11065	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACAN_RS11070	COG2255	four-way junction helicase activity
ACAN_RS11075	COG0628	permease
ACAN_RS11095	COG1518	maintenance of DNA repeat elements
ACAN_RS11135	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ACAN_RS11140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ACAN_RS11140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ACAN_RS11150	COG0542	response to heat
ACAN_RS11155	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ACAN_RS11160	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACAN_RS11175	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ACAN_RS11190	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACAN_RS11200	COG1157	protein secretion by the type III secretion system
ACAN_RS11210	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACAN_RS11230	COG1677	Flagellar hook-basal body complex protein FliE
ACAN_RS11240	COG0455	bacterial-type flagellum organization
ACAN_RS11245	COG1419	protein localization to endoplasmic reticulum
ACAN_RS11260	COG3951	Flagellar rod assembly protein muramidase FlgJ
ACAN_RS11270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ACAN_RS11295	COG1749	Flagellar hook protein flgE
ACAN_RS11300	COG1749	Flagellar hook protein flgE
ACAN_RS11310	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACAN_RS11320	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACAN_RS11325	COG1766	The M ring may be actively involved in energy transduction
ACAN_RS11330	COG1815	bacterial-type flagellum-dependent cell motility
ACAN_RS11335	COG4786	Flagellar basal body rod
ACAN_RS11345	COG0745	RESPONSE REGULATOR receiver
ACAN_RS11365	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACAN_RS11375	COG0228	four-way junction DNA binding
ACAN_RS11380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACAN_RS11390	COG1519	Transferase
ACAN_RS11400	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACAN_RS11405	COG0752	glycyl-tRNA synthetase alpha subunit
ACAN_RS11410	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACAN_RS11420	COG0826	peptidase U32
ACAN_RS11425	COG0840	transmembrane signaling receptor activity
ACAN_RS11425	COG0840	transmembrane signaling receptor activity
ACAN_RS11435	COG0497	DNA recombination
ACAN_RS11440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACAN_RS11445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACAN_RS11450	COG0049	tRNA binding
ACAN_RS11455	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACAN_RS11460	COG2814	Major facilitator Superfamily
ACAN_RS11465	COG2267	carboxylic ester hydrolase activity
ACAN_RS11480	COG1671	Belongs to the UPF0178 family
ACAN_RS11485	COG4895	conserved protein (DUF2196)
ACAN_RS11540	COG0745	RESPONSE REGULATOR receiver
ACAN_RS11555	COG2860	membrane
ACAN_RS11565	COG0582	viral genome integration into host DNA
ACAN_RS11585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACAN_RS11590	COG0085	RNA polymerase activity
ACAN_RS11595	COG0222	ribosome binding
ACAN_RS11600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACAN_RS11605	COG0081	regulation of translation
ACAN_RS11610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACAN_RS11615	COG0250	Participates in transcription elongation, termination and antitermination
ACAN_RS11630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACAN_RS11635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACAN_RS11660	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACAN_RS11665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACAN_RS11670	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ACAN_RS11680	COG4172	Belongs to the ABC transporter superfamily
ACAN_RS11685	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ACAN_RS11690	COG0174	glutamine synthetase
ACAN_RS11695	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ACAN_RS11705	COG0314	molybdopterin synthase activity
ACAN_RS11715	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACAN_RS11720	COG1968	undecaprenyl-diphosphatase activity
ACAN_RS11730	COG0772	Belongs to the SEDS family
ACAN_RS11735	COG0768	penicillin binding
ACAN_RS11740	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACAN_RS11785	COG0512	Glutamine amidotransferase of anthranilate synthase
ACAN_RS11795	COG1840	ABC-type Fe3 transport system, periplasmic component
ACAN_RS11805	COG3842	ATPase activity
ACAN_RS11810	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACAN_RS11815	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ACAN_RS11820	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAN_RS11825	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAN_RS11830	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAN_RS11830	COG0649	NAD binding
ACAN_RS11835	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ACAN_RS11845	COG0372	Belongs to the citrate synthase family
ACAN_RS11855	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACAN_RS11860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAN_RS11865	COG0839	Belongs to the complex I subunit 6 family
ACAN_RS11870	COG0713	ATP synthesis coupled electron transport
ACAN_RS11875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACAN_RS11885	COG1007	ATP synthesis coupled electron transport
ACAN_RS11895	COG1053	succinate dehydrogenase
ACAN_RS11900	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACAN_RS11910	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ACAN_RS11915	COG1929	Belongs to the glycerate kinase type-1 family
ACAN_RS11930	COG0038	chloride channel
ACAN_RS11945	COG1012	belongs to the aldehyde dehydrogenase family
ACAN_RS11980	COG2095	MarC family integral membrane protein
ACAN_RS11985	COG0765	amino acid transport
ACAN_RS12005	COG0500	methyltransferase
ACAN_RS12015	COG1335	isochorismatase
ACAN_RS12025	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ACAN_RS12030	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ACAN_RS12035	COG0514	ATP-dependent DNA helicase (RecQ)
ACAN_RS12040	COG1280	lysine exporter protein (LysE YggA)
ACAN_RS12050	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ACAN_RS12060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACAN_RS12065	COG2828	Protein conserved in bacteria
ACAN_RS12075	COG0181	hydroxymethylbilane synthase activity
ACAN_RS12090	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ACAN_RS12105	COG0784	Response regulator, receiver
ACAN_RS12110	COG4774	siderophore transport
ACAN_RS12110	COG1629	transport
ACAN_RS12115	COG2382	esterase
ACAN_RS12120	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ACAN_RS12125	COG0450	alkyl hydroperoxide reductase
ACAN_RS12135	COG0105	UTP biosynthetic process
ACAN_RS12145	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACAN_RS12150	COG0416	fatty acid biosynthetic process
ACAN_RS12155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACAN_RS12165	COG1687	branched-chain amino acid
ACAN_RS12170	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ACAN_RS12200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACAN_RS12205	COG0540	Belongs to the ATCase OTCase family
ACAN_RS12210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACAN_RS12225	COG0469	pyruvate kinase activity
ACAN_RS12245	COG0642	Histidine kinase
ACAN_RS12250	COG0745	RESPONSE REGULATOR receiver
ACAN_RS12260	COG0792	nuclease activity
ACAN_RS12265	COG0840	transmembrane signaling receptor activity
ACAN_RS12270	COG0156	8-amino-7-oxononanoate synthase activity
ACAN_RS12280	COG0288	reversible hydration of carbon dioxide
ACAN_RS12290	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACAN_RS12300	COG2121	Domain of unknown function (DUF374)
ACAN_RS12305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACAN_RS12315	COG0195	Participates in both transcription termination and antitermination
ACAN_RS12320	COG0215	cysteine-tRNA ligase activity
ACAN_RS12325	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACAN_RS12330	COG0629	single-stranded DNA binding
ACAN_RS12335	COG0360	Binds together with S18 to 16S ribosomal RNA
ACAN_RS12340	COG1466	dna polymerase III delta subunit
ACAN_RS12345	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ACAN_RS12350	COG0557	exoribonuclease II activity
ACAN_RS12365	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACAN_RS12425	COG0640	Transcriptional regulator
ACAN_RS12445	COG3328	transposase activity
ACAN_RS12495	COG4974	Belongs to the 'phage' integrase family
ACAN_RS12520	COG5002	protein histidine kinase activity
ACAN_RS12525	COG0745	RESPONSE REGULATOR receiver
ACAN_RS12530	COG3301	Polysulphide reductase, NrfD
ACAN_RS12535	COG0437	4 iron, 4 sulfur cluster binding
ACAN_RS12555	COG0436	Aminotransferase
ACAN_RS12565	COG0343	queuine tRNA-ribosyltransferase activity
ACAN_RS12570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACAN_RS12575	COG1393	Belongs to the ArsC family
ACAN_RS12580	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ACAN_RS12590	COG0560	Phosphoserine phosphatase
ACAN_RS12595	COG0646	methionine synthase
ACAN_RS12595	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ACAN_RS12600	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACAN_RS12605	COG0736	holo-[acyl-carrier-protein] synthase activity
ACAN_RS12610	COG0601	transmembrane transport
ACAN_RS12615	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACAN_RS12620	COG0745	RESPONSE REGULATOR receiver
ACAN_RS12625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACAN_RS12645	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ACAN_RS12650	COG4786	Flagellar basal body rod
ACAN_RS12650	COG1256	bacterial-type flagellum assembly
ACAN_RS12680	COG1987	bacterial-type flagellum assembly
ACAN_RS12690	COG1706	bacterial-type flagellum-dependent cell motility
ACAN_RS12695	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACAN_RS12700	COG0418	dihydroorotase activity
ACAN_RS12710	COG0004	ammonium transporteR
ACAN_RS12715	COG0347	Belongs to the P(II) protein family
ACAN_RS12720	COG0004	ammonium transporteR
ACAN_RS12740	COG0204	Acyl-transferase
ACAN_RS12740	COG0318	PFAM AMP-dependent synthetase and ligase
ACAN_RS12745	COG0640	Transcriptional regulator
ACAN_RS12750	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ACAN_RS12770	COG0598	Magnesium transport protein CorA
ACAN_RS12775	COG0659	secondary active sulfate transmembrane transporter activity
ACAN_RS12785	COG2962	Rard protein
ACAN_RS12790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACAN_RS12800	COG4536	flavin adenine dinucleotide binding
ACAN_RS12805	COG1346	cytolysis
ACAN_RS12810	COG1380	Effector of murein hydrolase LrgA
ACAN_RS12820	COG0840	transmembrane signaling receptor activity
ACAN_RS12825	COG0745	RESPONSE REGULATOR receiver
ACAN_RS12830	COG3852	Histidine kinase
ACAN_RS12835	COG0252	asparaginase activity
ACAN_RS12840	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ACAN_RS12845	COG1027	Aspartate ammonia-lyase
ACAN_RS12850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACAN_RS12855	COG1053	succinate dehydrogenase
ACAN_RS12865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACAN_RS12920	COG0628	permease
ACAN_RS12925	COG3852	Histidine kinase
ACAN_RS12955	COG0129	dihydroxy-acid dehydratase activity
ACAN_RS12965	COG0745	RESPONSE REGULATOR receiver
ACAN_RS12970	COG0642	Histidine kinase
ACAN_RS12975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ACAN_RS12985	COG0745	RESPONSE REGULATOR receiver
ACAN_RS13000	COG1492	cobalamin metabolic process
ACAN_RS13005	COG1490	D-aminoacyl-tRNA deacylase activity
ACAN_RS13010	COG1401	restriction endodeoxyribonuclease activity
ACAN_RS13015	COG4804	nuclease activity
ACAN_RS13030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACAN_RS13035	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ACAN_RS13045	COG2095	MarC family integral membrane protein
ACAN_RS13050	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ACAN_RS13080	COG3118	belongs to the thioredoxin family
ACAN_RS13110	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ACAN_RS13115	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ACAN_RS13125	COG0443	Heat shock 70 kDa protein
ACAN_RS13130	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACAN_RS13135	COG1420	regulation of RNA biosynthetic process
ACAN_RS13155	COG2358	TRAP transporter, solute receptor (TAXI family
ACAN_RS13170	COG0745	RESPONSE REGULATOR receiver
ACAN_RS13180	COG0101	tRNA pseudouridine synthase activity
ACAN_RS13195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACAN_RS13200	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACAN_RS13205	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACAN_RS13220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACAN_RS13285	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ACAN_RS13295	COG2089	acid synthase
ACAN_RS13300	COG2226	methyltransferase
ACAN_RS13320	COG3980	spore coat polysaccharide biosynthesis protein
ACAN_RS13325	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ACAN_RS13335	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACAN_RS13340	COG1086	Polysaccharide biosynthesis protein
ACAN_RS13345	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACAN_RS13350	COG0148	phosphopyruvate hydratase activity
ACAN_RS13365	COG0569	domain protein
ACAN_RS13365	COG0475	glutathione-regulated potassium exporter activity
ACAN_RS13370	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACAN_RS13390	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACAN_RS13400	COG1007	ATP synthesis coupled electron transport
ACAN_RS13410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACAN_RS13415	COG0713	ATP synthesis coupled electron transport
ACAN_RS13420	COG0839	Belongs to the complex I subunit 6 family
ACAN_RS13425	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAN_RS13430	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACAN_RS13450	COG0649	NAD binding
ACAN_RS13460	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAN_RS13465	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAN_RS13470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACAN_RS13490	COG0488	(ABC) transporter
ACAN_RS13495	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ACAN_RS13505	COG3287	FIST C domain
ACAN_RS13505	COG2200	EAL domain
ACAN_RS13505	COG2199	diguanylate cyclase activity
ACAN_RS13515	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACAN_RS13525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACAN_RS13530	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACAN_RS13535	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACAN_RS13540	COG1077	Cell shape determining protein MreB Mrl
ACAN_RS13565	COG0445	tRNA wobble uridine modification
ACAN_RS13570	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ACAN_RS13580	COG0348	domain, Protein
ACAN_RS13585	COG0504	CTP synthase activity
ACAN_RS13590	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACAN_RS13610	COG0471	metal ion transport
ACAN_RS13625	COG0587	DNA-directed DNA polymerase activity
ACAN_RS13630	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ACAN_RS13655	COG0315	cyclic pyranopterin monophosphate synthase activity
ACAN_RS13660	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ACAN_RS13665	COG0471	metal ion transport
ACAN_RS13670	COG0628	permease
ACAN_RS13705	COG0670	Belongs to the BI1 family
ACAN_RS13710	COG0352	thiamine-phosphate diphosphorylase activity
ACAN_RS13720	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACAN_RS13730	COG0233	cytoplasmic translational termination
ACAN_RS13735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACAN_RS13745	COG2814	Major facilitator Superfamily
ACAN_RS13750	COG3022	response to hydroperoxide
ACAN_RS13755	COG3012	SEC-C Motif Domain Protein
ACAN_RS13770	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ACAN_RS13775	COG1704	LemA family
ACAN_RS13815	COG0415	Belongs to the DNA photolyase family
ACAN_RS13820	COG2081	HI0933 family
ACAN_RS13835	COG1959	2 iron, 2 sulfur cluster binding
ACAN_RS13850	COG0175	sulfate reduction
ACAN_RS13855	COG0175	sulfate reduction
ACAN_RS13860	COG2895	sulfate adenylyltransferase (ATP) activity
ACAN_RS13865	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACAN_RS13870	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACAN_RS13875	COG0840	transmembrane signaling receptor activity
ACAN_RS13880	COG1408	metallophosphoesterase
ACAN_RS13895	COG1217	gtp-binding protein TYPA
ACAN_RS13900	COG2391	methyltransferase activity
ACAN_RS13905	COG0425	Belongs to the sulfur carrier protein TusA family
ACAN_RS13910	COG2066	Belongs to the glutaminase family
ACAN_RS13915	COG2860	membrane
ACAN_RS13920	COG0840	transmembrane signaling receptor activity
ACAN_RS13925	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ACAN_RS13930	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group