locus-tag	class	description
ACIB15232_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACIB15232_RS00010	COG0592	DNA-directed DNA polymerase activity
ACIB15232_RS00015	COG0187	DNA topoisomerase II activity
ACIB15232_RS00020	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACIB15232_RS00035	COG0500	methyltransferase
ACIB15232_RS00040	COG3842	ATPase activity
ACIB15232_RS00060	COG3174	membrane
ACIB15232_RS00080	COG2895	sulfate adenylyltransferase (ATP) activity
ACIB15232_RS00085	COG0175	sulfate reduction
ACIB15232_RS00105	COG1959	2 iron, 2 sulfur cluster binding
ACIB15232_RS00120	COG2081	HI0933 family
ACIB15232_RS00125	COG0840	transmembrane signaling receptor activity
ACIB15232_RS00145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACIB15232_RS00155	COG3706	GGDEF domain
ACIB15232_RS00165	COG2814	Major facilitator Superfamily
ACIB15232_RS00170	COG0783	Belongs to the Dps family
ACIB15232_RS00175	COG0546	phosphoglycolate phosphatase activity
ACIB15232_RS00185	COG1012	belongs to the aldehyde dehydrogenase family
ACIB15232_RS00190	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ACIB15232_RS00215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ACIB15232_RS00220	COG3022	response to hydroperoxide
ACIB15232_RS00240	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACIB15232_RS00245	COG0233	cytoplasmic translational termination
ACIB15232_RS00255	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACIB15232_RS00265	COG0352	thiamine-phosphate diphosphorylase activity
ACIB15232_RS00270	COG0670	Belongs to the BI1 family
ACIB15232_RS00320	COG1028	Short-chain dehydrogenase reductase Sdr
ACIB15232_RS00325	COG1083	cytidylyl-transferase
ACIB15232_RS00340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACIB15232_RS00345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACIB15232_RS00345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACIB15232_RS00350	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ACIB15232_RS00355	COG2089	acid synthase
ACIB15232_RS00365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACIB15232_RS00380	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACIB15232_RS00385	COG0148	phosphopyruvate hydratase activity
ACIB15232_RS00400	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACIB15232_RS00415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ACIB15232_RS00420	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACIB15232_RS00425	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ACIB15232_RS00430	COG0315	cyclic pyranopterin monophosphate synthase activity
ACIB15232_RS00445	COG1007	ATP synthesis coupled electron transport
ACIB15232_RS00455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACIB15232_RS00460	COG0713	ATP synthesis coupled electron transport
ACIB15232_RS00465	COG0839	Belongs to the complex I subunit 6 family
ACIB15232_RS00470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIB15232_RS00475	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACIB15232_RS00495	COG0649	NAD binding
ACIB15232_RS00500	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIB15232_RS00505	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIB15232_RS00510	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIB15232_RS00515	COG1222	aaa ATPase
ACIB15232_RS00530	COG0659	secondary active sulfate transmembrane transporter activity
ACIB15232_RS00535	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ACIB15232_RS00540	COG1252	NADH dehydrogenase
ACIB15232_RS00550	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACIB15232_RS00555	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACIB15232_RS00560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACIB15232_RS00565	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACIB15232_RS00570	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACIB15232_RS00590	COG0445	tRNA wobble uridine modification
ACIB15232_RS00595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACIB15232_RS00600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ACIB15232_RS00610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACIB15232_RS00615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACIB15232_RS00620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACIB15232_RS00635	COG0101	tRNA pseudouridine synthase activity
ACIB15232_RS00645	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACIB15232_RS00650	COG0443	Heat shock 70 kDa protein
ACIB15232_RS00655	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ACIB15232_RS00665	COG0688	phosphatidylethanolamine metabolic process
ACIB15232_RS00670	COG3287	FIST C domain
ACIB15232_RS00670	COG2199	diguanylate cyclase activity
ACIB15232_RS00670	COG2200	EAL domain
ACIB15232_RS00685	COG0189	ligase activity
ACIB15232_RS00690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACIB15232_RS00695	COG3118	belongs to the thioredoxin family
ACIB15232_RS00725	COG1028	Short-chain dehydrogenase reductase Sdr
ACIB15232_RS00735	COG0642	Histidine kinase
ACIB15232_RS00740	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS00750	COG0129	dihydroxy-acid dehydratase activity
ACIB15232_RS00810	COG0849	cell division
ACIB15232_RS00850	COG0642	Histidine kinase
ACIB15232_RS00855	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS00895	COG1136	(ABC) transporter
ACIB15232_RS00905	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ACIB15232_RS00910	COG0585	pseudouridine synthase activity
ACIB15232_RS00925	COG0793	Belongs to the peptidase S41A family
ACIB15232_RS00935	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACIB15232_RS00940	COG0047	phosphoribosylformylglycinamidine synthase activity
ACIB15232_RS00950	COG0204	Acyl-transferase
ACIB15232_RS00960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACIB15232_RS00965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACIB15232_RS00970	COG0018	arginyl-trna synthetase
ACIB15232_RS00980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ACIB15232_RS00985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACIB15232_RS00990	COG0126	phosphoglycerate kinase activity
ACIB15232_RS00995	COG0149	triose-phosphate isomerase activity
ACIB15232_RS01000	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACIB15232_RS01005	COG0019	diaminopimelate decarboxylase activity
ACIB15232_RS01010	COG0077	Prephenate dehydratase
ACIB15232_RS01010	COG1605	Chorismate mutase
ACIB15232_RS01015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACIB15232_RS01020	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACIB15232_RS01030	COG0424	maF-like protein
ACIB15232_RS01040	COG0791	NLP P60 protein
ACIB15232_RS01045	COG0791	NLP P60 protein
ACIB15232_RS01065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACIB15232_RS01070	COG3118	belongs to the thioredoxin family
ACIB15232_RS01075	COG0492	ferredoxin-NADP+ reductase activity
ACIB15232_RS01080	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACIB15232_RS01085	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ACIB15232_RS01105	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACIB15232_RS01110	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACIB15232_RS01115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACIB15232_RS01120	COG3278	Belongs to the heme-copper respiratory oxidase family
ACIB15232_RS01165	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACIB15232_RS01170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACIB15232_RS01175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACIB15232_RS01180	COG0539	negative regulation of cytoplasmic translation
ACIB15232_RS01180	COG1185	polyribonucleotide nucleotidyltransferase activity
ACIB15232_RS01185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACIB15232_RS01190	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACIB15232_RS01195	COG0072	phenylalanine-tRNA ligase activity
ACIB15232_RS01195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACIB15232_RS01200	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACIB15232_RS01205	COG0537	adenosine 5'-monophosphoramidase activity
ACIB15232_RS01210	COG0825	malonyl-CoA metabolic process
ACIB15232_RS01215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACIB15232_RS01220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACIB15232_RS01230	COG0602	queuosine metabolic process
ACIB15232_RS01240	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACIB15232_RS01265	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ACIB15232_RS01275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACIB15232_RS01280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACIB15232_RS01295	COG0356	it plays a direct role in the translocation of protons across the membrane
ACIB15232_RS01300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACIB15232_RS01305	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACIB15232_RS01315	COG0336	Belongs to the RNA methyltransferase TrmD family
ACIB15232_RS01320	COG0335	large ribosomal subunit rRNA binding
ACIB15232_RS01325	COG0586	Pfam SNARE associated Golgi protein
ACIB15232_RS01330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACIB15232_RS01345	COG0251	oxidation-reduction process
ACIB15232_RS01355	COG2183	response to ionizing radiation
ACIB15232_RS01385	COG1178	ABC-type Fe3 transport system permease component
ACIB15232_RS01390	COG1840	ABC-type Fe3 transport system, periplasmic component
ACIB15232_RS01395	COG0512	Glutamine amidotransferase of anthranilate synthase
ACIB15232_RS01435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACIB15232_RS01440	COG0768	penicillin binding
ACIB15232_RS01445	COG0772	Belongs to the SEDS family
ACIB15232_RS01450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACIB15232_RS01455	COG1968	undecaprenyl-diphosphatase activity
ACIB15232_RS01460	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACIB15232_RS01470	COG0314	molybdopterin synthase activity
ACIB15232_RS01480	COG0174	glutamine synthetase
ACIB15232_RS01485	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ACIB15232_RS01495	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ACIB15232_RS01500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACIB15232_RS01505	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACIB15232_RS01530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACIB15232_RS01535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACIB15232_RS01550	COG0250	Participates in transcription elongation, termination and antitermination
ACIB15232_RS01555	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACIB15232_RS01560	COG0081	regulation of translation
ACIB15232_RS01565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACIB15232_RS01570	COG0222	ribosome binding
ACIB15232_RS01575	COG0085	RNA polymerase activity
ACIB15232_RS01580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACIB15232_RS01595	COG0840	transmembrane signaling receptor activity
ACIB15232_RS01600	COG0450	alkyl hydroperoxide reductase
ACIB15232_RS01605	COG3118	belongs to the thioredoxin family
ACIB15232_RS01610	COG1971	Probably functions as a manganese efflux pump
ACIB15232_RS01640	COG0840	transmembrane signaling receptor activity
ACIB15232_RS01645	COG2814	Major facilitator Superfamily
ACIB15232_RS01655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACIB15232_RS01660	COG0049	tRNA binding
ACIB15232_RS01665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACIB15232_RS01670	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACIB15232_RS01675	COG0497	DNA recombination
ACIB15232_RS01680	COG0840	transmembrane signaling receptor activity
ACIB15232_RS01680	COG0840	transmembrane signaling receptor activity
ACIB15232_RS01685	COG0826	peptidase U32
ACIB15232_RS01695	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACIB15232_RS01705	COG0752	glycyl-tRNA synthetase alpha subunit
ACIB15232_RS01710	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACIB15232_RS01720	COG1519	Transferase
ACIB15232_RS01720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ACIB15232_RS01725	COG0564	pseudouridine synthase activity
ACIB15232_RS01730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACIB15232_RS01735	COG0228	four-way junction DNA binding
ACIB15232_RS01740	COG1837	Belongs to the UPF0109 family
ACIB15232_RS01745	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACIB15232_RS01765	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS01775	COG4786	Flagellar basal body rod
ACIB15232_RS01780	COG1815	bacterial-type flagellum-dependent cell motility
ACIB15232_RS01785	COG1766	The M ring may be actively involved in energy transduction
ACIB15232_RS01790	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACIB15232_RS01800	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACIB15232_RS01810	COG1749	Flagellar hook protein flgE
ACIB15232_RS01815	COG1749	Flagellar hook protein flgE
ACIB15232_RS01835	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACIB15232_RS01855	COG1419	protein localization to endoplasmic reticulum
ACIB15232_RS01860	COG0455	bacterial-type flagellum organization
ACIB15232_RS01870	COG1677	Flagellar hook-basal body complex protein FliE
ACIB15232_RS01890	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACIB15232_RS01900	COG1157	protein secretion by the type III secretion system
ACIB15232_RS01905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ACIB15232_RS01910	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACIB15232_RS01920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACIB15232_RS01925	COG1970	mechanosensitive ion channel activity
ACIB15232_RS01950	COG2030	dehydratase
ACIB15232_RS01965	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACIB15232_RS01970	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ACIB15232_RS01975	COG0542	response to heat
ACIB15232_RS02010	COG2801	Transposase and inactivated derivatives
ACIB15232_RS02015	COG1295	ribonuclease BN
ACIB15232_RS02020	COG0277	FAD linked oxidase domain protein
ACIB15232_RS02030	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACIB15232_RS02035	COG2226	methyltransferase
ACIB15232_RS02050	COG1739	Uncharacterized protein family UPF0029
ACIB15232_RS02065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACIB15232_RS02075	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ACIB15232_RS02080	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACIB15232_RS02085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACIB15232_RS02090	COG0284	orotidine-5'-phosphate decarboxylase activity
ACIB15232_RS02155	COG0483	inositol monophosphate 1-phosphatase activity
ACIB15232_RS02160	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACIB15232_RS02170	COG0859	PFAM glycosyl transferase family 9
ACIB15232_RS02185	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ACIB15232_RS02225	COG1216	Glycosyl transferase, family 2
ACIB15232_RS02230	COG1216	Glycosyl transferase, family 2
ACIB15232_RS02240	COG1696	Membrane protein involved in D-alanine export
ACIB15232_RS02250	COG1696	Membrane protein involved in D-alanine export
ACIB15232_RS02260	COG0438	transferase activity, transferring glycosyl groups
ACIB15232_RS02275	COG0463	Glycosyl transferase, family 2
ACIB15232_RS02290	COG0859	PFAM glycosyl transferase family 9
ACIB15232_RS02295	COG1368	sulfuric ester hydrolase activity
ACIB15232_RS02300	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ACIB15232_RS02305	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACIB15232_RS02305	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACIB15232_RS02325	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACIB15232_RS02335	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ACIB15232_RS02350	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ACIB15232_RS02360	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACIB15232_RS02400	COG4628	conserved protein (DUF2132)
ACIB15232_RS02425	COG1570	exodeoxyribonuclease VII activity
ACIB15232_RS02430	COG0835	chemotaxis
ACIB15232_RS02435	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS02445	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ACIB15232_RS02450	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACIB15232_RS02460	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACIB15232_RS02465	COG0459	protein refolding
ACIB15232_RS02485	COG5002	protein histidine kinase activity
ACIB15232_RS02495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACIB15232_RS02500	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACIB15232_RS02505	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ACIB15232_RS02510	COG0352	thiamine-phosphate diphosphorylase activity
ACIB15232_RS02515	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ACIB15232_RS02525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACIB15232_RS02530	COG2264	protein methyltransferase activity
ACIB15232_RS02535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACIB15232_RS02540	COG0628	permease
ACIB15232_RS02545	COG2255	four-way junction helicase activity
ACIB15232_RS02550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACIB15232_RS02555	COG0159	tryptophan synthase activity
ACIB15232_RS02560	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ACIB15232_RS02570	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ACIB15232_RS02595	COG2207	Transcriptional regulator
ACIB15232_RS02595	COG4753	response regulator
ACIB15232_RS02600	COG4191	Histidine kinase
ACIB15232_RS02625	COG3706	GGDEF domain
ACIB15232_RS02635	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACIB15232_RS02655	COG1846	Transcriptional regulator
ACIB15232_RS02660	COG1028	Short-chain dehydrogenase reductase Sdr
ACIB15232_RS02700	COG2326	polyphosphate kinase activity
ACIB15232_RS02705	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACIB15232_RS02710	COG0740	serine-type endopeptidase activity
ACIB15232_RS02715	COG0242	peptide deformylase activity
ACIB15232_RS02725	COG0606	chelatase, subunit chli
ACIB15232_RS02735	COG1484	DNA-dependent DNA replication
ACIB15232_RS02770	COG0606	chelatase, subunit chli
ACIB15232_RS02775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACIB15232_RS02845	COG1309	transcriptional regulator
ACIB15232_RS02855	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ACIB15232_RS02860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ACIB15232_RS02865	COG0653	protein targeting
ACIB15232_RS02875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACIB15232_RS02880	COG2095	MarC family integral membrane protein
ACIB15232_RS02890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACIB15232_RS02895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ACIB15232_RS02905	COG0481	GTPase activity
ACIB15232_RS02910	COG2885	chlorophyll binding
ACIB15232_RS02920	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACIB15232_RS02945	COG0482	sulfurtransferase activity
ACIB15232_RS02950	COG0482	sulfurtransferase activity
ACIB15232_RS02955	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACIB15232_RS02960	COG0006	proline dipeptidase activity
ACIB15232_RS02965	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACIB15232_RS02970	COG0402	S-adenosylhomocysteine deaminase activity
ACIB15232_RS02975	COG0616	signal peptide processing
ACIB15232_RS02985	COG0280	phosphate acetyltransferase
ACIB15232_RS02990	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACIB15232_RS02995	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACIB15232_RS03000	COG2176	DNA-directed DNA polymerase activity
ACIB15232_RS03010	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACIB15232_RS03040	COG2176	DNA-directed DNA polymerase activity
ACIB15232_RS03050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACIB15232_RS03060	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS03110	COG1058	Belongs to the CinA family
ACIB15232_RS03110	COG1546	Belongs to the CinA family
ACIB15232_RS03115	COG0579	oxidoreductase
ACIB15232_RS03120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACIB15232_RS03135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACIB15232_RS03140	COG0052	Belongs to the universal ribosomal protein uS2 family
ACIB15232_RS03145	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACIB15232_RS03150	COG1136	(ABC) transporter
ACIB15232_RS03160	COG0194	GDP metabolic process
ACIB15232_RS03170	COG2217	Heavy metal translocating P-type atpase
ACIB15232_RS03185	COG4608	Belongs to the ABC transporter superfamily
ACIB15232_RS03190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACIB15232_RS03195	COG1227	inorganic diphosphatase activity
ACIB15232_RS03200	COG0668	transmembrane transport
ACIB15232_RS03205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ACIB15232_RS03215	COG0010	Belongs to the arginase family
ACIB15232_RS03220	COG1278	Cold shock
ACIB15232_RS03225	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACIB15232_RS03230	COG0581	inorganic phosphate transmembrane transporter activity
ACIB15232_RS03235	COG0573	inorganic phosphate transmembrane transporter activity
ACIB15232_RS03275	COG2995	paraquat-inducible protein a
ACIB15232_RS03280	COG3008	intermembrane lipid transfer
ACIB15232_RS03300	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ACIB15232_RS03310	COG0326	Molecular chaperone. Has ATPase activity
ACIB15232_RS03315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIB15232_RS03320	COG0842	Transport permease protein
ACIB15232_RS03320	COG1129	ABC transporter
ACIB15232_RS03325	COG0842	Transport permease protein
ACIB15232_RS03335	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACIB15232_RS03340	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ACIB15232_RS03345	COG0840	transmembrane signaling receptor activity
ACIB15232_RS03360	COG2199	diguanylate cyclase activity
ACIB15232_RS03360	COG2200	EAL domain
ACIB15232_RS03360	COG3287	FIST C domain
ACIB15232_RS03375	COG0513	Belongs to the DEAD box helicase family
ACIB15232_RS03385	COG0259	pyridoxamine-phosphate oxidase activity
ACIB15232_RS03405	COG5002	protein histidine kinase activity
ACIB15232_RS03405	COG5001	Diguanylate cyclase
ACIB15232_RS03415	COG5002	protein histidine kinase activity
ACIB15232_RS03420	COG1121	(ABC) transporter
ACIB15232_RS03425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACIB15232_RS03430	COG2996	Protein conserved in bacteria
ACIB15232_RS03435	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ACIB15232_RS03445	COG0673	inositol 2-dehydrogenase activity
ACIB15232_RS03460	COG0210	DNA helicase
ACIB15232_RS03465	COG0569	domain protein
ACIB15232_RS03465	COG0475	glutathione-regulated potassium exporter activity
ACIB15232_RS03470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACIB15232_RS03550	COG0582	viral genome integration into host DNA
ACIB15232_RS03600	COG1921	L-seryl-tRNASec selenium transferase activity
ACIB15232_RS03625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACIB15232_RS03635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACIB15232_RS03645	COG0386	Belongs to the glutathione peroxidase family
ACIB15232_RS03655	COG1078	dGTPase activity
ACIB15232_RS03670	COG0709	Synthesizes selenophosphate from selenide and ATP
ACIB15232_RS03675	COG1305	Transglutaminase-like
ACIB15232_RS03690	COG4565	transcriptional regulatory protein
ACIB15232_RS03730	COG0437	4 iron, 4 sulfur cluster binding
ACIB15232_RS03740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ACIB15232_RS03760	COG2998	abc-type tungstate transport system, permease component
ACIB15232_RS03765	COG4662	Binding-protein-dependent transport system inner membrane component
ACIB15232_RS03785	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACIB15232_RS03790	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACIB15232_RS03800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACIB15232_RS03805	COG0306	phosphate transporter
ACIB15232_RS03820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACIB15232_RS03825	COG0328	RNA-DNA hybrid ribonuclease activity
ACIB15232_RS03830	COG0840	transmembrane signaling receptor activity
ACIB15232_RS03845	COG0513	Belongs to the DEAD box helicase family
ACIB15232_RS03850	COG2217	Heavy metal translocating P-type atpase
ACIB15232_RS03860	COG1032	radical SAM domain protein
ACIB15232_RS03865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACIB15232_RS03870	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACIB15232_RS03875	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ACIB15232_RS03880	COG0095	Lipoate-protein ligase
ACIB15232_RS03885	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACIB15232_RS03900	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACIB15232_RS03905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACIB15232_RS03905	COG0519	Catalyzes the synthesis of GMP from XMP
ACIB15232_RS03930	COG0596	Alpha beta hydrolase
ACIB15232_RS03940	COG0116	Belongs to the methyltransferase superfamily
ACIB15232_RS03940	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ACIB15232_RS03950	COG2989	Protein conserved in bacteria
ACIB15232_RS03975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACIB15232_RS03995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACIB15232_RS03995	COG0301	tRNA thio-modification
ACIB15232_RS04010	COG2814	Major facilitator Superfamily
ACIB15232_RS04025	COG2354	Protein conserved in bacteria
ACIB15232_RS04030	COG0726	polysaccharide deacetylase
ACIB15232_RS04035	COG2081	HI0933 family
ACIB15232_RS04060	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACIB15232_RS04065	COG2171	N-acyltransferase activity
ACIB15232_RS04075	COG0488	(ABC) transporter
ACIB15232_RS04080	COG1944	ATP diphosphatase activity
ACIB15232_RS04090	COG2169	Transcriptional regulator
ACIB15232_RS04090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACIB15232_RS04095	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACIB15232_RS04105	COG0475	glutathione-regulated potassium exporter activity
ACIB15232_RS04105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACIB15232_RS04115	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ACIB15232_RS04135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACIB15232_RS04140	COG1611	Belongs to the LOG family
ACIB15232_RS04160	COG0217	transcriptional regulatory protein
ACIB15232_RS04190	COG1049	propionate catabolic process, 2-methylcitrate cycle
ACIB15232_RS04195	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ACIB15232_RS04205	COG1451	nucleotide metabolic process
ACIB15232_RS04225	COG2884	Cell division ATP-binding protein ftsE
ACIB15232_RS04230	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ACIB15232_RS04240	COG0564	pseudouridine synthase activity
ACIB15232_RS04245	COG0772	Belongs to the SEDS family
ACIB15232_RS04250	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ACIB15232_RS04255	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACIB15232_RS04260	COG3123	guanosine phosphorylase activity
ACIB15232_RS04275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACIB15232_RS04280	COG0066	3-isopropylmalate dehydratase activity
ACIB15232_RS04285	COG0473	3-isopropylmalate dehydrogenase activity
ACIB15232_RS04300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ACIB15232_RS04305	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACIB15232_RS04310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACIB15232_RS04315	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACIB15232_RS04320	COG0202	RNA polymerase activity
ACIB15232_RS04325	COG0203	ribosomal protein L17
ACIB15232_RS04330	COG0154	amidase activity
ACIB15232_RS04335	COG0516	GMP reductase activity
ACIB15232_RS04335	COG0517	IMP dehydrogenase activity
ACIB15232_RS04350	COG0840	transmembrane signaling receptor activity
ACIB15232_RS04355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACIB15232_RS04360	COG0840	transmembrane signaling receptor activity
ACIB15232_RS04365	COG0754	glutathionylspermidine amidase activity
ACIB15232_RS04375	COG1119	ATPase activity
ACIB15232_RS04380	COG2076	Multidrug Resistance protein
ACIB15232_RS04400	COG2249	NAD(P)H dehydrogenase (quinone) activity
ACIB15232_RS04405	COG1881	PFAM PEBP family protein
ACIB15232_RS04430	COG2855	membrane
ACIB15232_RS04455	COG1733	regulation of RNA biosynthetic process
ACIB15232_RS04460	COG2249	NAD(P)H dehydrogenase (quinone) activity
ACIB15232_RS04470	COG0778	Nitroreductase
ACIB15232_RS04480	COG0488	(ABC) transporter
ACIB15232_RS04485	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACIB15232_RS04500	COG0702	epimerase
ACIB15232_RS04505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACIB15232_RS04525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIB15232_RS04535	COG3437	response regulator, receiver
ACIB15232_RS04535	COG0784	Response regulator, receiver
ACIB15232_RS04540	COG1338	Plays a role in the flagellum-specific transport system
ACIB15232_RS04545	COG0768	penicillin binding
ACIB15232_RS04570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACIB15232_RS04575	COG0322	excinuclease ABC activity
ACIB15232_RS04580	COG3201	nicotinamide mononucleotide transporter
ACIB15232_RS04625	COG1741	Belongs to the pirin family
ACIB15232_RS04630	COG2205	protein histidine kinase activity
ACIB15232_RS04635	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS04645	COG4895	conserved protein (DUF2196)
ACIB15232_RS04650	COG0784	Response regulator, receiver
ACIB15232_RS04650	COG3437	response regulator, receiver
ACIB15232_RS04665	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ACIB15232_RS04670	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS04675	COG0642	Histidine kinase
ACIB15232_RS04680	COG3111	PFAM Bacterial OB fold (BOF) protein
ACIB15232_RS04685	COG3328	transposase activity
ACIB15232_RS04690	COG3328	transposase activity
ACIB15232_RS04720	COG0659	secondary active sulfate transmembrane transporter activity
ACIB15232_RS04745	COG1484	DNA-dependent DNA replication
ACIB15232_RS04750	COG4584	PFAM Integrase catalytic
ACIB15232_RS04785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ACIB15232_RS04860	COG0582	viral genome integration into host DNA
ACIB15232_RS04865	COG0824	Thioesterase
ACIB15232_RS04875	COG0501	Belongs to the peptidase M48B family
ACIB15232_RS04880	COG1322	Protein conserved in bacteria
ACIB15232_RS04885	COG2321	neutral zinc metallopeptidase
ACIB15232_RS04895	COG0303	'Molybdopterin
ACIB15232_RS04905	COG0037	tRNA processing
ACIB15232_RS04915	COG3118	belongs to the thioredoxin family
ACIB15232_RS04930	COG2203	Gaf domain
ACIB15232_RS04930	COG5001	Diguanylate cyclase
ACIB15232_RS04930	COG4251	negative regulation of phosphorylation
ACIB15232_RS04930	COG3706	GGDEF domain
ACIB15232_RS04940	COG0248	Ppx GppA phosphatase
ACIB15232_RS04950	COG0028	Belongs to the TPP enzyme family
ACIB15232_RS04955	COG0440	acetolactate synthase activity
ACIB15232_RS04960	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACIB15232_RS04965	COG1196	nuclear chromosome segregation
ACIB15232_RS04965	COG1674	ftsk spoiiie
ACIB15232_RS04975	COG1114	Component of the transport system for branched-chain amino acids
ACIB15232_RS04980	COG0861	Integral membrane protein TerC family
ACIB15232_RS04985	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS04995	COG0113	porphobilinogen synthase activity
ACIB15232_RS05000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACIB15232_RS05005	COG0357	Ribosomal RNA small subunit methyltransferase G
ACIB15232_RS05020	COG0751	glycine-tRNA ligase activity
ACIB15232_RS05025	COG0582	viral genome integration into host DNA
ACIB15232_RS05035	COG1137	ATPase activity
ACIB15232_RS05045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACIB15232_RS05055	COG0137	argininosuccinate synthase activity
ACIB15232_RS05060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACIB15232_RS05065	COG1696	Membrane protein involved in D-alanine export
ACIB15232_RS05075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACIB15232_RS05100	COG0310	cobalt ion transport
ACIB15232_RS05110	COG0375	protein maturation
ACIB15232_RS05115	COG0309	Hydrogenase expression formation protein (HypE)
ACIB15232_RS05125	COG2084	Dehydrogenase
ACIB15232_RS05135	COG0298	carbon dioxide binding
ACIB15232_RS05140	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ACIB15232_RS05155	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ACIB15232_RS05175	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ACIB15232_RS05180	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ACIB15232_RS05205	COG0484	heat shock protein binding
ACIB15232_RS05225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACIB15232_RS05230	COG3300	MHYT domain
ACIB15232_RS05230	COG5001	Diguanylate cyclase
ACIB15232_RS05235	COG4251	negative regulation of phosphorylation
ACIB15232_RS05235	COG2203	Gaf domain
ACIB15232_RS05235	COG3706	GGDEF domain
ACIB15232_RS05235	COG5001	Diguanylate cyclase
ACIB15232_RS05255	COG0166	Belongs to the GPI family
ACIB15232_RS05275	COG0708	Exodeoxyribonuclease III
ACIB15232_RS05280	COG0500	methyltransferase
ACIB15232_RS05285	COG1333	cytochrome c biogenesis protein
ACIB15232_RS05285	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACIB15232_RS05290	COG2195	Cleaves the N-terminal amino acid of tripeptides
ACIB15232_RS05300	COG1193	negative regulation of DNA recombination
ACIB15232_RS05310	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACIB15232_RS05320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACIB15232_RS05325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACIB15232_RS05335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACIB15232_RS05350	COG0339	signal peptide processing
ACIB15232_RS05355	COG2890	protein-(glutamine-N5) methyltransferase activity
ACIB15232_RS05360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACIB15232_RS05365	COG0494	nUDIX hydrolase
ACIB15232_RS05370	COG0527	aspartate kinase activity
ACIB15232_RS05385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACIB15232_RS05390	COG1253	flavin adenine dinucleotide binding
ACIB15232_RS05400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACIB15232_RS05420	COG2211	Major facilitator Superfamily
ACIB15232_RS05425	COG0300	oxidoreductase activity
ACIB15232_RS05430	COG0287	Prephenate dehydrogenase
ACIB15232_RS05435	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACIB15232_RS05440	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACIB15232_RS05445	COG0612	Peptidase, M16
ACIB15232_RS05450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACIB15232_RS05475	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ACIB15232_RS05485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACIB15232_RS05485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACIB15232_RS05500	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ACIB15232_RS05505	COG2201	protein-glutamate methylesterase activity
ACIB15232_RS05510	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ACIB15232_RS05515	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACIB15232_RS05525	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS05530	COG1185	polyribonucleotide nucleotidyltransferase activity
ACIB15232_RS05560	COG1160	GTP binding
ACIB15232_RS05585	COG0039	L-malate dehydrogenase activity
ACIB15232_RS05610	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ACIB15232_RS05610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACIB15232_RS05615	COG2201	protein-glutamate methylesterase activity
ACIB15232_RS05630	COG0484	heat shock protein binding
ACIB15232_RS05635	COG0789	Transcriptional regulator
ACIB15232_RS05655	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACIB15232_RS05660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACIB15232_RS05665	COG1663	tetraacyldisaccharide 4'-kinase activity
ACIB15232_RS05670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACIB15232_RS05690	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACIB15232_RS05710	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ACIB15232_RS05715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACIB15232_RS05720	COG0805	protein transport
ACIB15232_RS05725	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ACIB15232_RS05750	COG0247	lactate metabolic process
ACIB15232_RS05750	COG2181	nitrate reductase activity
ACIB15232_RS05755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACIB15232_RS05770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACIB15232_RS05770	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACIB15232_RS05775	COG3706	GGDEF domain
ACIB15232_RS05785	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ACIB15232_RS05800	COG0275	rRNA processing
ACIB15232_RS05810	COG0776	regulation of translation
ACIB15232_RS05825	COG4974	Belongs to the 'phage' integrase family
ACIB15232_RS05885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACIB15232_RS05890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACIB15232_RS05895	COG1722	exodeoxyribonuclease VII activity
ACIB15232_RS05900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACIB15232_RS05910	COG2391	methyltransferase activity
ACIB15232_RS05915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACIB15232_RS05920	COG0849	cell division
ACIB15232_RS05940	COG1393	Belongs to the ArsC family
ACIB15232_RS05960	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ACIB15232_RS05965	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ACIB15232_RS05970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACIB15232_RS05975	COG3328	transposase activity
ACIB15232_RS06010	COG0330	HflC and HflK could
ACIB15232_RS06025	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS06040	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ACIB15232_RS06045	COG0788	formyltetrahydrofolate deformylase activity
ACIB15232_RS06060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACIB15232_RS06210	COG1917	Cupin 2, conserved barrel domain protein
ACIB15232_RS06210	COG2207	Transcriptional regulator
ACIB15232_RS06215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACIB15232_RS06245	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ACIB15232_RS06285	COG3706	GGDEF domain
ACIB15232_RS06295	COG0840	transmembrane signaling receptor activity
ACIB15232_RS06315	COG0513	Belongs to the DEAD box helicase family
ACIB15232_RS06320	COG0667	Aldo Keto reductase
ACIB15232_RS06340	COG2176	DNA-directed DNA polymerase activity
ACIB15232_RS06345	COG0135	phosphoribosylanthranilate isomerase activity
ACIB15232_RS06350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACIB15232_RS06370	COG0642	Histidine kinase
ACIB15232_RS06375	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS06380	COG1666	GTP binding
ACIB15232_RS06385	COG2363	Small membrane protein
ACIB15232_RS06390	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ACIB15232_RS06420	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS06425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACIB15232_RS06425	COG4191	Histidine kinase
ACIB15232_RS06430	COG0513	Belongs to the DEAD box helicase family
ACIB15232_RS06435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACIB15232_RS06445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACIB15232_RS06450	COG4771	TonB-dependent receptor
ACIB15232_RS06475	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ACIB15232_RS06480	COG0653	protein targeting
ACIB15232_RS06505	COG0642	Histidine kinase
ACIB15232_RS06510	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS06520	COG1132	(ABC) transporter
ACIB15232_RS06530	COG5001	Diguanylate cyclase
ACIB15232_RS06530	COG3300	MHYT domain
ACIB15232_RS06540	COG3040	lipid binding
ACIB15232_RS06545	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACIB15232_RS06550	COG3046	protein related to deoxyribodipyrimidine photolyase
ACIB15232_RS06565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACIB15232_RS06575	COG2200	EAL domain
ACIB15232_RS06580	COG3279	Response regulator of the LytR AlgR family
ACIB15232_RS06585	COG3275	phosphorelay sensor kinase activity
ACIB15232_RS06590	COG1233	COG1233 Phytoene dehydrogenase and related
ACIB15232_RS06595	COG0415	Belongs to the DNA photolyase family
ACIB15232_RS06605	COG1090	epimerase
ACIB15232_RS06610	COG1472	Belongs to the glycosyl hydrolase 3 family
ACIB15232_RS06615	COG0484	heat shock protein binding
ACIB15232_RS06620	COG0484	heat shock protein binding
ACIB15232_RS06630	COG1607	acyl-coa hydrolase
ACIB15232_RS06635	COG0456	acetyltransferase
ACIB15232_RS06640	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACIB15232_RS06655	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACIB15232_RS06660	COG0131	Imidazoleglycerol-phosphate dehydratase
ACIB15232_RS06665	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACIB15232_RS06670	COG1388	LysM domain
ACIB15232_RS06670	COG0741	lytic transglycosylase activity
ACIB15232_RS06675	COG0084	hydrolase, TatD family'
ACIB15232_RS06690	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ACIB15232_RS06695	COG0359	binds to the 23S rRNA
ACIB15232_RS06705	COG0163	prenyltransferase activity
ACIB15232_RS06710	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACIB15232_RS06715	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACIB15232_RS06720	COG0124	histidyl-tRNA synthetase
ACIB15232_RS06725	COG1166	arginine decarboxylase activity
ACIB15232_RS06730	COG1045	serine acetyltransferase
ACIB15232_RS06735	COG0730	response to heat
ACIB15232_RS06750	COG0488	(ABC) transporter
ACIB15232_RS06760	COG3706	GGDEF domain
ACIB15232_RS06765	COG0642	Histidine kinase
ACIB15232_RS06770	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS06780	COG3258	Cytochrome c
ACIB15232_RS06790	COG0300	oxidoreductase activity
ACIB15232_RS06795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACIB15232_RS06800	COG0742	ribosomal rna small subunit methyltransferase
ACIB15232_RS06805	COG1418	mRNA catabolic process
ACIB15232_RS06810	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ACIB15232_RS06820	COG0552	protein localization to endoplasmic reticulum
ACIB15232_RS06835	COG1858	cytochrome C peroxidase
ACIB15232_RS06860	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ACIB15232_RS06870	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACIB15232_RS06875	COG0735	belongs to the Fur family
ACIB15232_RS06885	COG0728	peptidoglycan biosynthetic process
ACIB15232_RS06890	COG1132	(ABC) transporter
ACIB15232_RS06895	COG0167	dihydroorotate dehydrogenase activity
ACIB15232_RS06905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACIB15232_RS06910	COG1028	Short-chain dehydrogenase reductase Sdr
ACIB15232_RS06915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACIB15232_RS06920	COG0750	zinc metalloprotease
ACIB15232_RS06925	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ACIB15232_RS06930	COG1942	4-Oxalocrotonate Tautomerase
ACIB15232_RS06940	COG0134	indole-3-glycerol-phosphate synthase activity
ACIB15232_RS06950	COG0727	PFAM Uncharacterised protein family (UPF0153)
ACIB15232_RS06955	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ACIB15232_RS06965	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACIB15232_RS06965	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACIB15232_RS06970	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACIB15232_RS06980	COG1979	alcohol dehydrogenase
ACIB15232_RS06985	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ACIB15232_RS06995	COG0563	adenylate kinase activity
ACIB15232_RS07000	COG0563	adenylate kinase activity
ACIB15232_RS07010	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACIB15232_RS07020	COG1573	uracil-dna glycosylase
ACIB15232_RS07025	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACIB15232_RS07030	COG0024	Methionine aminopeptidase
ACIB15232_RS07035	COG0201	protein transport
ACIB15232_RS07040	COG0200	Binds to the 23S rRNA
ACIB15232_RS07045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACIB15232_RS07050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACIB15232_RS07055	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACIB15232_RS07060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACIB15232_RS07065	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACIB15232_RS07070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACIB15232_RS07075	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACIB15232_RS07080	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACIB15232_RS07085	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACIB15232_RS07090	COG0255	Belongs to the universal ribosomal protein uL29 family
ACIB15232_RS07095	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACIB15232_RS07100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACIB15232_RS07105	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACIB15232_RS07110	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACIB15232_RS07115	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACIB15232_RS07120	COG0089	rRNA binding
ACIB15232_RS07125	COG0088	Forms part of the polypeptide exit tunnel
ACIB15232_RS07130	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACIB15232_RS07135	COG0051	transcription antitermination factor activity, RNA binding
ACIB15232_RS07150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACIB15232_RS07155	COG2267	carboxylic ester hydrolase activity
ACIB15232_RS07160	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACIB15232_RS07165	COG0632	four-way junction helicase activity
ACIB15232_RS07170	COG0840	transmembrane signaling receptor activity
ACIB15232_RS07185	COG0585	pseudouridine synthase activity
ACIB15232_RS07190	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ACIB15232_RS07205	COG3123	guanosine phosphorylase activity
ACIB15232_RS07225	COG0012	GTP binding
ACIB15232_RS07235	COG1879	ABC-type sugar transport system periplasmic component
ACIB15232_RS07240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACIB15232_RS07240	COG4191	Histidine kinase
ACIB15232_RS07245	COG1966	Carbon starvation protein
ACIB15232_RS07280	COG4771	TonB-dependent receptor
ACIB15232_RS07285	COG3706	GGDEF domain
ACIB15232_RS07290	COG0577	efflux transmembrane transporter activity
ACIB15232_RS07290	COG1136	(ABC) transporter
ACIB15232_RS07295	COG1136	(ABC) transporter
ACIB15232_RS07295	COG0577	efflux transmembrane transporter activity
ACIB15232_RS07310	COG0811	peptide transport
ACIB15232_RS07315	COG0848	biopolymer transport protein
ACIB15232_RS07325	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACIB15232_RS07335	COG0133	tryptophan synthase activity
ACIB15232_RS07340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACIB15232_RS07350	COG0305	Participates in initiation and elongation during chromosome replication
ACIB15232_RS07355	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACIB15232_RS07370	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACIB15232_RS07375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACIB15232_RS07385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACIB15232_RS07390	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ACIB15232_RS07395	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ACIB15232_RS07405	COG0528	UMP kinase activity
ACIB15232_RS07410	COG1758	RNA polymerase activity
ACIB15232_RS07420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACIB15232_RS07430	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACIB15232_RS07445	COG0193	aminoacyl-tRNA hydrolase activity
ACIB15232_RS07450	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ACIB15232_RS07455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACIB15232_RS07460	COG0681	Belongs to the peptidase S26 family
ACIB15232_RS07465	COG0698	ribose 5-phosphate isomerase
ACIB15232_RS07485	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ACIB15232_RS07490	COG0556	nucleotide-excision repair
ACIB15232_RS07500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACIB15232_RS07505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ACIB15232_RS07510	COG0835	chemotaxis
ACIB15232_RS07510	COG0784	Response regulator, receiver
ACIB15232_RS07515	COG0165	Argininosuccinate lyase
ACIB15232_RS07520	COG3706	GGDEF domain
ACIB15232_RS07525	COG2239	Acts as a magnesium transporter
ACIB15232_RS07530	COG2906	2 iron, 2 sulfur cluster binding
ACIB15232_RS07530	COG0822	iron-sulfur transferase activity
ACIB15232_RS07530	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ACIB15232_RS07535	COG0719	Fe-S assembly protein
ACIB15232_RS07540	COG0396	ATPase activity
ACIB15232_RS07550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACIB15232_RS07555	COG2166	iron-sulfur cluster assembly
ACIB15232_RS07565	COG0439	Biotin carboxylase
ACIB15232_RS07575	COG0840	transmembrane signaling receptor activity
ACIB15232_RS07580	COG0840	transmembrane signaling receptor activity
ACIB15232_RS07605	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACIB15232_RS07610	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACIB15232_RS07615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ACIB15232_RS07635	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACIB15232_RS07640	COG2814	Major facilitator Superfamily
ACIB15232_RS07655	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ACIB15232_RS07675	COG0525	valine-tRNA ligase activity
ACIB15232_RS07680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACIB15232_RS07680	COG1648	precorrin-2 dehydrogenase activity
ACIB15232_RS07690	COG0252	asparaginase activity
ACIB15232_RS07695	COG1027	Aspartate ammonia-lyase
ACIB15232_RS07700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACIB15232_RS07705	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ACIB15232_RS07710	COG1047	Peptidyl-prolyl cis-trans
ACIB15232_RS07725	COG0823	Involved in the tonB-independent uptake of proteins
ACIB15232_RS07735	COG0848	biopolymer transport protein
ACIB15232_RS07740	COG0811	peptide transport
ACIB15232_RS07745	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACIB15232_RS07750	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACIB15232_RS07755	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACIB15232_RS07760	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACIB15232_RS07765	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACIB15232_RS07770	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ACIB15232_RS07780	COG1475	DNA binding
ACIB15232_RS07785	COG1192	Involved in chromosome partitioning
ACIB15232_RS07800	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACIB15232_RS07805	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACIB15232_RS07810	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACIB15232_RS07815	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACIB15232_RS07820	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACIB15232_RS07825	COG0358	DNA primase activity
ACIB15232_RS07835	COG0571	ribonuclease III activity
ACIB15232_RS07840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACIB15232_RS07850	COG2194	sulfuric ester hydrolase activity
ACIB15232_RS07855	COG0501	Belongs to the peptidase M48B family
ACIB15232_RS07875	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACIB15232_RS07885	COG0706	membrane insertase activity
ACIB15232_RS07890	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACIB15232_RS07895	COG0594	ribonuclease P activity
ACIB15232_RS07900	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ACIB15232_RS07905	COG0542	response to heat
ACIB15232_RS07910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACIB15232_RS07915	COG2326	polyphosphate kinase activity
ACIB15232_RS07930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACIB15232_RS07940	COG0494	nUDIX hydrolase
ACIB15232_RS07960	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACIB15232_RS07970	COG0739	heme binding
ACIB15232_RS07980	COG0598	Magnesium transport protein CorA
ACIB15232_RS08000	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACIB15232_RS08040	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ACIB15232_RS08045	COG1858	cytochrome C peroxidase
ACIB15232_RS08075	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACIB15232_RS08105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACIB15232_RS08115	COG1692	metallophosphoesterase
ACIB15232_RS08125	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACIB15232_RS08135	COG0840	transmembrane signaling receptor activity
ACIB15232_RS08140	COG2081	HI0933 family
ACIB15232_RS08145	COG0642	Histidine kinase
ACIB15232_RS08150	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS08160	COG4251	negative regulation of phosphorylation
ACIB15232_RS08160	COG5001	Diguanylate cyclase
ACIB15232_RS08160	COG3706	GGDEF domain
ACIB15232_RS08160	COG2203	Gaf domain
ACIB15232_RS08185	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ACIB15232_RS08220	COG0285	dihydrofolate synthase activity
ACIB15232_RS08230	COG0495	leucyl-tRNA aminoacylation
ACIB15232_RS08240	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ACIB15232_RS08245	COG1360	Flagellar Motor Protein
ACIB15232_RS08255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACIB15232_RS08260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACIB15232_RS08265	COG1862	Preprotein translocase
ACIB15232_RS08270	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ACIB15232_RS08285	COG0617	tRNA 3'-terminal CCA addition
ACIB15232_RS08290	COG0668	transmembrane transport
ACIB15232_RS08295	COG0442	prolyl-tRNA aminoacylation
ACIB15232_RS08300	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACIB15232_RS08305	COG0142	geranyltranstransferase activity
ACIB15232_RS08315	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACIB15232_RS08320	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACIB15232_RS08330	COG0811	peptide transport
ACIB15232_RS08335	COG0848	biopolymer transport protein
ACIB15232_RS08340	COG0191	fructose-bisphosphate aldolase activity
ACIB15232_RS08345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACIB15232_RS08350	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS08355	COG0642	Histidine kinase
ACIB15232_RS08360	COG1832	CoA-binding protein
ACIB15232_RS08365	COG2404	hydrolase activity, acting on ester bonds
ACIB15232_RS08375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACIB15232_RS08380	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACIB15232_RS08385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACIB15232_RS08405	COG0243	molybdopterin cofactor binding
ACIB15232_RS08410	COG0437	4 iron, 4 sulfur cluster binding
ACIB15232_RS08415	COG0348	domain, Protein
ACIB15232_RS08420	COG3043	anaerobic respiration
ACIB15232_RS08440	COG0840	transmembrane signaling receptor activity
ACIB15232_RS08445	COG5002	protein histidine kinase activity
ACIB15232_RS08445	COG5001	Diguanylate cyclase
ACIB15232_RS08460	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACIB15232_RS08470	COG3204	pilus organization
ACIB15232_RS08480	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACIB15232_RS08495	COG3610	response to peptide
ACIB15232_RS08500	COG3610	response to peptide
ACIB15232_RS08505	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACIB15232_RS08510	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIB15232_RS08515	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIB15232_RS08520	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIB15232_RS08520	COG0649	NAD binding
ACIB15232_RS08525	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ACIB15232_RS08535	COG0372	Belongs to the citrate synthase family
ACIB15232_RS08540	COG1034	ATP synthesis coupled electron transport
ACIB15232_RS08545	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACIB15232_RS08550	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIB15232_RS08555	COG0839	Belongs to the complex I subunit 6 family
ACIB15232_RS08560	COG0713	ATP synthesis coupled electron transport
ACIB15232_RS08565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACIB15232_RS08575	COG1007	ATP synthesis coupled electron transport
ACIB15232_RS08585	COG1053	succinate dehydrogenase
ACIB15232_RS08590	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACIB15232_RS08605	COG2824	Alkylphosphonate utilization operon protein PhnA
ACIB15232_RS08630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACIB15232_RS08640	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ACIB15232_RS08650	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACIB15232_RS08655	COG2828	Protein conserved in bacteria
ACIB15232_RS08660	COG1335	isochorismatase
ACIB15232_RS08665	COG0181	hydroxymethylbilane synthase activity
ACIB15232_RS08675	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ACIB15232_RS08680	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ACIB15232_RS08685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACIB15232_RS08690	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ACIB15232_RS08695	COG0450	alkyl hydroperoxide reductase
ACIB15232_RS08705	COG0105	UTP biosynthetic process
ACIB15232_RS08715	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACIB15232_RS08720	COG0416	fatty acid biosynthetic process
ACIB15232_RS08725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACIB15232_RS08745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACIB15232_RS08750	COG0540	Belongs to the ATCase OTCase family
ACIB15232_RS08760	COG4773	Receptor
ACIB15232_RS08770	COG1706	bacterial-type flagellum-dependent cell motility
ACIB15232_RS08805	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ACIB15232_RS08815	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ACIB15232_RS08830	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACIB15232_RS08840	COG0288	reversible hydration of carbon dioxide
ACIB15232_RS08845	COG0156	8-amino-7-oxononanoate synthase activity
ACIB15232_RS08855	COG0792	nuclease activity
ACIB15232_RS08870	COG2885	chlorophyll binding
ACIB15232_RS08890	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ACIB15232_RS08895	COG0587	DNA-directed DNA polymerase activity
ACIB15232_RS08915	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ACIB15232_RS08915	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACIB15232_RS08920	COG0504	CTP synthase activity
ACIB15232_RS08925	COG0348	domain, Protein
ACIB15232_RS08935	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACIB15232_RS08945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ACIB15232_RS08955	COG0157	Belongs to the NadC ModD family
ACIB15232_RS08960	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ACIB15232_RS08970	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ACIB15232_RS08980	COG0083	homoserine kinase activity
ACIB15232_RS08990	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACIB15232_RS08995	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACIB15232_RS09000	COG0779	Required for maturation of 30S ribosomal subunits
ACIB15232_RS09005	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACIB15232_RS09005	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACIB15232_RS09015	COG2121	Domain of unknown function (DUF374)
ACIB15232_RS09020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACIB15232_RS09030	COG0195	Participates in both transcription termination and antitermination
ACIB15232_RS09035	COG0215	cysteine-tRNA ligase activity
ACIB15232_RS09040	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACIB15232_RS09045	COG0629	single-stranded DNA binding
ACIB15232_RS09050	COG0360	Binds together with S18 to 16S ribosomal RNA
ACIB15232_RS09065	COG0557	exoribonuclease II activity
ACIB15232_RS09070	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACIB15232_RS09100	COG0343	queuine tRNA-ribosyltransferase activity
ACIB15232_RS09105	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACIB15232_RS09110	COG1393	Belongs to the ArsC family
ACIB15232_RS09115	COG3248	Nucleoside-binding outer membrane protein
ACIB15232_RS09120	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ACIB15232_RS09130	COG0560	Phosphoserine phosphatase
ACIB15232_RS09140	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACIB15232_RS09155	COG0736	holo-[acyl-carrier-protein] synthase activity
ACIB15232_RS09160	COG0601	transmembrane transport
ACIB15232_RS09165	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACIB15232_RS09175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACIB15232_RS09185	COG0418	dihydroorotase activity
ACIB15232_RS09205	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ACIB15232_RS09215	COG1301	dicarboxylic acid transport
ACIB15232_RS09245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACIB15232_RS09250	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ACIB15232_RS09270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACIB15232_RS09285	COG4191	Histidine kinase
ACIB15232_RS09295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIB15232_RS09330	COG0840	transmembrane signaling receptor activity
ACIB15232_RS09350	COG0511	ligase activity, forming carbon-carbon bonds
ACIB15232_RS09385	COG2022	thiamine diphosphate biosynthetic process
ACIB15232_RS09395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACIB15232_RS09395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ACIB15232_RS09405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACIB15232_RS09420	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ACIB15232_RS09425	COG0575	Belongs to the CDS family
ACIB15232_RS09450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACIB15232_RS09460	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACIB15232_RS09465	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACIB15232_RS09480	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACIB15232_RS09485	COG0746	molybdenum cofactor guanylyltransferase activity
ACIB15232_RS09490	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACIB15232_RS09495	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACIB15232_RS09500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACIB15232_RS09505	COG0268	Binds directly to 16S ribosomal RNA
ACIB15232_RS09510	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACIB15232_RS09515	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ACIB15232_RS09520	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ACIB15232_RS09525	COG0573	inorganic phosphate transmembrane transporter activity
ACIB15232_RS09530	COG0581	inorganic phosphate transmembrane transporter activity
ACIB15232_RS09535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACIB15232_RS09540	COG0704	Plays a role in the regulation of phosphate uptake
ACIB15232_RS09550	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS09555	COG2205	protein histidine kinase activity
ACIB15232_RS09560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACIB15232_RS09565	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACIB15232_RS09575	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ACIB15232_RS09585	COG0351	phosphomethylpyrimidine kinase
ACIB15232_RS09585	COG0352	thiamine-phosphate diphosphorylase activity
ACIB15232_RS09595	COG0546	phosphoglycolate phosphatase activity
ACIB15232_RS09620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACIB15232_RS09625	COG1854	S-ribosylhomocysteine lyase activity
ACIB15232_RS09635	COG1686	Belongs to the peptidase S11 family
ACIB15232_RS09645	COG0505	Belongs to the CarA family
ACIB15232_RS09655	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACIB15232_RS09660	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ACIB15232_RS09665	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ACIB15232_RS09680	COG2353	YceI-like domain
ACIB15232_RS09700	COG0460	homoserine dehydrogenase
ACIB15232_RS09705	COG0436	Aminotransferase
ACIB15232_RS09715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACIB15232_RS09720	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ACIB15232_RS09725	COG0254	rRNA binding
ACIB15232_RS09730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACIB15232_RS09765	COG4974	Belongs to the 'phage' integrase family
ACIB15232_RS09770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACIB15232_RS09775	COG1086	Polysaccharide biosynthesis protein
ACIB15232_RS09785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACIB15232_RS09810	COG1086	Polysaccharide biosynthesis protein
ACIB15232_RS09875	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ACIB15232_RS10030	COG3550	peptidyl-serine autophosphorylation
ACIB15232_RS10055	COG0556	nucleotide-excision repair
ACIB15232_RS10080	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ACIB15232_RS10105	COG4584	PFAM Integrase catalytic
ACIB15232_RS10205	COG0237	dephospho-CoA kinase activity
ACIB15232_RS10210	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACIB15232_RS10225	COG1410	methionine synthase
ACIB15232_RS10225	COG0646	methionine synthase
ACIB15232_RS10235	COG0803	Belongs to the bacterial solute-binding protein 9 family
ACIB15232_RS10245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACIB15232_RS10270	COG0140	phosphoribosyl-ATP diphosphatase activity
ACIB15232_RS10270	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACIB15232_RS10280	COG0489	protein tyrosine kinase activity
ACIB15232_RS10295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACIB15232_RS10295	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACIB15232_RS10300	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS10305	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ACIB15232_RS10310	COG2353	YceI-like domain
ACIB15232_RS10315	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACIB15232_RS10340	COG0642	Histidine kinase
ACIB15232_RS10345	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS10350	COG0724	RNA recognition motif
ACIB15232_RS10355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACIB15232_RS10360	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACIB15232_RS10375	COG0107	imidazoleglycerol-phosphate synthase activity
ACIB15232_RS10380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACIB15232_RS10390	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ACIB15232_RS10390	COG0517	IMP dehydrogenase activity
ACIB15232_RS10395	COG1187	pseudouridine synthase activity
ACIB15232_RS10400	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACIB15232_RS10400	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ACIB15232_RS10405	COG1981	membrane
ACIB15232_RS10410	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ACIB15232_RS10420	COG0367	asparagine synthase
ACIB15232_RS10430	COG0306	phosphate transporter
ACIB15232_RS10435	COG0513	Belongs to the DEAD box helicase family
ACIB15232_RS10440	COG0439	Biotin carboxylase
ACIB15232_RS10445	COG0511	ligase activity, forming carbon-carbon bonds
ACIB15232_RS10450	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACIB15232_RS10450	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACIB15232_RS10460	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACIB15232_RS10465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACIB15232_RS10470	COG0604	alcohol dehydrogenase
ACIB15232_RS10485	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACIB15232_RS10490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACIB15232_RS10495	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACIB15232_RS10500	COG0564	pseudouridine synthase activity
ACIB15232_RS10510	COG2860	membrane
ACIB15232_RS10515	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ACIB15232_RS10525	COG0642	Histidine kinase
ACIB15232_RS10530	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS10570	COG0425	Belongs to the sulfur carrier protein TusA family
ACIB15232_RS10585	COG1217	gtp-binding protein TYPA
ACIB15232_RS10590	COG1959	2 iron, 2 sulfur cluster binding
ACIB15232_RS10595	COG2199	diguanylate cyclase activity
ACIB15232_RS10595	COG2200	EAL domain
ACIB15232_RS10595	COG3287	FIST C domain
ACIB15232_RS10600	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ACIB15232_RS10605	COG4208	sulfate ABC transporter
ACIB15232_RS10620	COG1408	metallophosphoesterase
ACIB15232_RS10625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACIB15232_RS10635	COG0133	tryptophan synthase activity
ACIB15232_RS10645	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ACIB15232_RS10670	COG0305	Participates in initiation and elongation during chromosome replication
ACIB15232_RS10680	COG1475	DNA binding
ACIB15232_RS10685	COG1192	Involved in chromosome partitioning
ACIB15232_RS10690	COG0514	ATP-dependent DNA helicase (RecQ)
ACIB15232_RS10755	COG0071	Belongs to the small heat shock protein (HSP20) family
ACIB15232_RS10760	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS10765	COG4191	Histidine kinase
ACIB15232_RS10830	COG3152	Membrane
ACIB15232_RS10880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACIB15232_RS10885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACIB15232_RS10890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIB15232_RS10895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACIB15232_RS10900	COG1116	anion transmembrane transporter activity
ACIB15232_RS10915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACIB15232_RS10920	COG0765	amino acid transport
ACIB15232_RS10925	COG4215	(ABC) transporter
ACIB15232_RS10930	COG1126	abc transporter atp-binding protein
ACIB15232_RS10935	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ACIB15232_RS10940	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACIB15232_RS10975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACIB15232_RS10980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACIB15232_RS10985	COG1045	serine acetyltransferase
ACIB15232_RS11000	COG0840	transmembrane signaling receptor activity
ACIB15232_RS11005	COG0840	transmembrane signaling receptor activity
ACIB15232_RS11025	COG0840	transmembrane signaling receptor activity
ACIB15232_RS11040	COG1742	UPF0060 membrane protein
ACIB15232_RS11050	COG0840	transmembrane signaling receptor activity
ACIB15232_RS11055	COG0428	transporter
ACIB15232_RS11060	COG4771	TonB-dependent receptor
ACIB15232_RS11080	COG0071	Belongs to the small heat shock protein (HSP20) family
ACIB15232_RS11095	COG0582	viral genome integration into host DNA
ACIB15232_RS11100	COG4895	conserved protein (DUF2196)
ACIB15232_RS11105	COG4191	Histidine kinase
ACIB15232_RS11125	COG2337	Toxic component of a toxin-antitoxin (TA) module
ACIB15232_RS11130	COG1278	Cold shock
ACIB15232_RS11155	COG4584	PFAM Integrase catalytic
ACIB15232_RS11230	COG4895	conserved protein (DUF2196)
ACIB15232_RS11235	COG1222	aaa ATPase
ACIB15232_RS11330	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ACIB15232_RS11365	COG0776	regulation of translation
ACIB15232_RS11505	COG0210	DNA helicase
ACIB15232_RS11530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACIB15232_RS11650	COG2207	Transcriptional regulator
ACIB15232_RS11650	COG1917	Cupin 2, conserved barrel domain protein
ACIB15232_RS11675	COG3111	PFAM Bacterial OB fold (BOF) protein
ACIB15232_RS11680	COG0642	Histidine kinase
ACIB15232_RS11695	COG0745	RESPONSE REGULATOR receiver
ACIB15232_RS11740	COG2356	endonuclease I
ACIB15232_RS11765	COG3118	belongs to the thioredoxin family
ACIB15232_RS11770	COG0450	alkyl hydroperoxide reductase
ACIB15232_RS11775	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ACIB15232_RS11780	COG0840	transmembrane signaling receptor activity
ACIB15232_RS11785	COG0840	transmembrane signaling receptor activity
ACIB15232_RS11795	COG4628	conserved protein (DUF2132)