locus-tag	class	description
ACLO_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACLO_RS00010	COG0592	DNA-directed DNA polymerase activity
ACLO_RS00015	COG0187	DNA topoisomerase II activity
ACLO_RS00020	COG0492	ferredoxin-NADP+ reductase activity
ACLO_RS00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACLO_RS00035	COG1238	metal cluster binding
ACLO_RS00040	COG0477	Major facilitator Superfamily
ACLO_RS00045	COG0564	pseudouridine synthase activity
ACLO_RS00050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACLO_RS00055	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACLO_RS00060	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACLO_RS00085	COG2954	triphosphatase activity
ACLO_RS00090	COG1151	hydroxylamine reductase activity
ACLO_RS00100	COG0493	'glutamate synthase
ACLO_RS00110	COG0052	Belongs to the universal ribosomal protein uS2 family
ACLO_RS00115	COG0604	alcohol dehydrogenase
ACLO_RS00125	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACLO_RS00130	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACLO_RS00145	COG0745	RESPONSE REGULATOR receiver
ACLO_RS00150	COG4191	Histidine kinase
ACLO_RS00155	COG1556	Lactate utilization protein
ACLO_RS00160	COG1139	Iron-sulfur cluster binding protein
ACLO_RS00165	COG0247	lactate metabolic process
ACLO_RS00175	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACLO_RS00180	COG0511	ligase activity, forming carbon-carbon bonds
ACLO_RS00185	COG0439	Biotin carboxylase
ACLO_RS00190	COG0513	Belongs to the DEAD box helicase family
ACLO_RS00195	COG0306	phosphate transporter
ACLO_RS00205	COG0367	asparagine synthase
ACLO_RS00215	COG0778	Nitroreductase
ACLO_RS00225	COG1053	succinate dehydrogenase
ACLO_RS00235	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ACLO_RS00245	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ACLO_RS00245	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACLO_RS00250	COG1187	pseudouridine synthase activity
ACLO_RS00255	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ACLO_RS00255	COG0517	IMP dehydrogenase activity
ACLO_RS00265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACLO_RS00270	COG0107	imidazoleglycerol-phosphate synthase activity
ACLO_RS00285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACLO_RS00290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACLO_RS00295	COG0724	RNA recognition motif
ACLO_RS00300	COG0745	RESPONSE REGULATOR receiver
ACLO_RS00305	COG0642	Histidine kinase
ACLO_RS00310	COG3706	GGDEF domain
ACLO_RS00330	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACLO_RS00335	COG2353	YceI-like domain
ACLO_RS00345	COG0534	Mate efflux family protein
ACLO_RS00350	COG0460	homoserine dehydrogenase
ACLO_RS00355	COG0436	Aminotransferase
ACLO_RS00370	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ACLO_RS00375	COG0254	rRNA binding
ACLO_RS00380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACLO_RS00495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACLO_RS00525	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ACLO_RS00530	COG3951	Flagellar rod assembly protein muramidase FlgJ
ACLO_RS00530	COG1705	Flagellar rod assembly protein muramidase FlgJ
ACLO_RS00535	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACLO_RS00540	COG0237	dephospho-CoA kinase activity
ACLO_RS00545	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ACLO_RS00550	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACLO_RS00555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACLO_RS00565	COG3384	dioxygenase
ACLO_RS00575	COG1846	Transcriptional regulator
ACLO_RS00580	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ACLO_RS00585	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ACLO_RS00590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACLO_RS00600	COG0505	Belongs to the CarA family
ACLO_RS00615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACLO_RS00615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACLO_RS00630	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACLO_RS00635	COG0489	protein tyrosine kinase activity
ACLO_RS00645	COG0140	phosphoribosyl-ATP diphosphatase activity
ACLO_RS00645	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACLO_RS00665	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACLO_RS00670	COG0840	transmembrane signaling receptor activity
ACLO_RS00680	COG0646	methionine synthase
ACLO_RS00680	COG1410	methionine synthase
ACLO_RS00685	COG0450	alkyl hydroperoxide reductase
ACLO_RS00700	COG1979	alcohol dehydrogenase
ACLO_RS00705	COG4191	Histidine kinase
ACLO_RS00715	COG1686	Belongs to the peptidase S11 family
ACLO_RS00730	COG1854	S-ribosylhomocysteine lyase activity
ACLO_RS00760	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACLO_RS00765	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACLO_RS00780	COG3180	Ammonia monooxygenase
ACLO_RS00785	COG1733	regulation of RNA biosynthetic process
ACLO_RS00790	COG2249	NAD(P)H dehydrogenase (quinone) activity
ACLO_RS00795	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACLO_RS00800	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACLO_RS00810	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACLO_RS00815	COG0546	phosphoglycolate phosphatase activity
ACLO_RS00825	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACLO_RS00830	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACLO_RS00840	COG0745	RESPONSE REGULATOR receiver
ACLO_RS00850	COG0704	Plays a role in the regulation of phosphate uptake
ACLO_RS00855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACLO_RS00860	COG0581	inorganic phosphate transmembrane transporter activity
ACLO_RS00865	COG0573	inorganic phosphate transmembrane transporter activity
ACLO_RS00870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ACLO_RS00880	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACLO_RS00885	COG0268	Binds directly to 16S ribosomal RNA
ACLO_RS00890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACLO_RS00895	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACLO_RS00900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACLO_RS00910	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACLO_RS00920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACLO_RS00925	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACLO_RS00930	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACLO_RS00960	COG0575	Belongs to the CDS family
ACLO_RS00965	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ACLO_RS00985	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACLO_RS00995	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ACLO_RS00995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACLO_RS01000	COG1324	tolerance protein
ACLO_RS01005	COG2022	thiamine diphosphate biosynthetic process
ACLO_RS01045	COG1002	Type II restriction enzyme, methylase subunits
ACLO_RS01060	COG3177	Filamentation induced by cAMP protein fic
ACLO_RS01065	COG1061	Type III restriction enzyme res subunit
ACLO_RS01070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ACLO_RS01090	COG0745	RESPONSE REGULATOR receiver
ACLO_RS01105	COG2337	Toxic component of a toxin-antitoxin (TA) module
ACLO_RS01110	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ACLO_RS01120	COG1742	UPF0060 membrane protein
ACLO_RS01125	COG2217	Heavy metal translocating P-type atpase
ACLO_RS01160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ACLO_RS01165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACLO_RS01170	COG0745	RESPONSE REGULATOR receiver
ACLO_RS01190	COG0642	Histidine kinase
ACLO_RS01200	COG5002	protein histidine kinase activity
ACLO_RS01220	COG2217	Heavy metal translocating P-type atpase
ACLO_RS01240	COG2132	Multicopper oxidase
ACLO_RS01265	COG0628	permease
ACLO_RS01270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACLO_RS01285	COG1968	undecaprenyl-diphosphatase activity
ACLO_RS01425	COG0582	viral genome integration into host DNA
ACLO_RS01445	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ACLO_RS01450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACLO_RS01470	COG0840	transmembrane signaling receptor activity
ACLO_RS01515	COG4191	Histidine kinase
ACLO_RS01520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACLO_RS01540	COG1346	cytolysis
ACLO_RS01565	COG0659	secondary active sulfate transmembrane transporter activity
ACLO_RS01595	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ACLO_RS01605	COG3290	protein histidine kinase activity
ACLO_RS01620	COG0004	ammonium transporteR
ACLO_RS01625	COG0347	Belongs to the P(II) protein family
ACLO_RS01630	COG0004	ammonium transporteR
ACLO_RS01640	COG0418	dihydroorotase activity
ACLO_RS01650	COG1706	bacterial-type flagellum-dependent cell motility
ACLO_RS01685	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ACLO_RS01690	COG1256	bacterial-type flagellum assembly
ACLO_RS01690	COG4786	Flagellar basal body rod
ACLO_RS01695	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ACLO_RS01715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACLO_RS01720	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACLO_RS01725	COG0601	transmembrane transport
ACLO_RS01730	COG0736	holo-[acyl-carrier-protein] synthase activity
ACLO_RS01735	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACLO_RS01745	COG0560	Phosphoserine phosphatase
ACLO_RS01750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACLO_RS01755	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ACLO_RS01760	COG3248	Nucleoside-binding outer membrane protein
ACLO_RS01765	COG1393	Belongs to the ArsC family
ACLO_RS01770	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACLO_RS01775	COG0343	queuine tRNA-ribosyltransferase activity
ACLO_RS01785	COG0436	Aminotransferase
ACLO_RS01805	COG2861	carbohydrate metabolic process
ACLO_RS01810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACLO_RS01815	COG0557	exoribonuclease II activity
ACLO_RS01820	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ACLO_RS01830	COG0360	Binds together with S18 to 16S ribosomal RNA
ACLO_RS01835	COG0629	single-stranded DNA binding
ACLO_RS01840	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACLO_RS01850	COG0215	cysteine-tRNA ligase activity
ACLO_RS01855	COG0195	Participates in both transcription termination and antitermination
ACLO_RS01865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACLO_RS01870	COG2121	Domain of unknown function (DUF374)
ACLO_RS01880	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACLO_RS01890	COG0288	reversible hydration of carbon dioxide
ACLO_RS01895	COG0156	8-amino-7-oxononanoate synthase activity
ACLO_RS01900	COG0792	nuclease activity
ACLO_RS01920	COG0469	pyruvate kinase activity
ACLO_RS01925	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ACLO_RS01935	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACLO_RS01945	COG0540	Belongs to the ATCase OTCase family
ACLO_RS01950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACLO_RS01955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACLO_RS01970	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ACLO_RS01975	COG1687	branched-chain amino acid
ACLO_RS01980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACLO_RS01985	COG0416	fatty acid biosynthetic process
ACLO_RS01990	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACLO_RS02000	COG0105	UTP biosynthetic process
ACLO_RS02010	COG0450	alkyl hydroperoxide reductase
ACLO_RS02015	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ACLO_RS02020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACLO_RS02025	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ACLO_RS02030	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ACLO_RS02040	COG0181	hydroxymethylbilane synthase activity
ACLO_RS02050	COG5001	Diguanylate cyclase
ACLO_RS02055	COG2828	Protein conserved in bacteria
ACLO_RS02060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACLO_RS02070	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ACLO_RS02080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACLO_RS02105	COG0514	ATP-dependent DNA helicase (RecQ)
ACLO_RS02110	COG0500	methyltransferase
ACLO_RS02125	COG1451	nucleotide metabolic process
ACLO_RS02140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACLO_RS02145	COG1053	succinate dehydrogenase
ACLO_RS02155	COG1007	ATP synthesis coupled electron transport
ACLO_RS02165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACLO_RS02170	COG0713	ATP synthesis coupled electron transport
ACLO_RS02180	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACLO_RS02185	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACLO_RS02190	COG1034	ATP synthesis coupled electron transport
ACLO_RS02195	COG0372	Belongs to the citrate synthase family
ACLO_RS02210	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACLO_RS02210	COG0649	NAD binding
ACLO_RS02215	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACLO_RS02220	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACLO_RS02225	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ACLO_RS02230	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACLO_RS02235	COG3610	response to peptide
ACLO_RS02240	COG2966	Psort location CytoplasmicMembrane, score
ACLO_RS02250	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACLO_RS02255	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACLO_RS02270	COG3706	GGDEF domain
ACLO_RS02290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACLO_RS02305	COG0840	transmembrane signaling receptor activity
ACLO_RS02325	COG3043	anaerobic respiration
ACLO_RS02330	COG0348	domain, Protein
ACLO_RS02335	COG0437	4 iron, 4 sulfur cluster binding
ACLO_RS02340	COG0243	molybdopterin cofactor binding
ACLO_RS02365	COG2204	response regulator
ACLO_RS02370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACLO_RS02390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACLO_RS02395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACLO_RS02410	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ACLO_RS02415	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACLO_RS02420	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACLO_RS02425	COG1959	2 iron, 2 sulfur cluster binding
ACLO_RS02430	COG2404	hydrolase activity, acting on ester bonds
ACLO_RS02440	COG0642	Histidine kinase
ACLO_RS02445	COG0745	RESPONSE REGULATOR receiver
ACLO_RS02455	COG0191	fructose-bisphosphate aldolase activity
ACLO_RS02460	COG3842	ATPase activity
ACLO_RS02470	COG1177	transmembrane transport
ACLO_RS02475	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ACLO_RS02480	COG1278	Cold shock
ACLO_RS02490	COG0811	peptide transport
ACLO_RS02500	COG4191	Histidine kinase
ACLO_RS02510	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACLO_RS02515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACLO_RS02525	COG0142	geranyltranstransferase activity
ACLO_RS02530	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACLO_RS02535	COG0442	prolyl-tRNA aminoacylation
ACLO_RS02540	COG0668	transmembrane transport
ACLO_RS02545	COG0617	tRNA 3'-terminal CCA addition
ACLO_RS02565	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ACLO_RS02570	COG1862	Preprotein translocase
ACLO_RS02575	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACLO_RS02580	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACLO_RS02590	COG0495	leucyl-tRNA aminoacylation
ACLO_RS02600	COG0285	dihydrofolate synthase activity
ACLO_RS02675	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ACLO_RS02685	COG2203	Gaf domain
ACLO_RS02685	COG4251	negative regulation of phosphorylation
ACLO_RS02685	COG5001	Diguanylate cyclase
ACLO_RS02685	COG3706	GGDEF domain
ACLO_RS02695	COG0745	RESPONSE REGULATOR receiver
ACLO_RS02700	COG0642	Histidine kinase
ACLO_RS02705	COG2081	HI0933 family
ACLO_RS02710	COG0840	transmembrane signaling receptor activity
ACLO_RS02720	COG3920	Histidine kinase
ACLO_RS02725	COG5000	phosphorelay sensor kinase activity
ACLO_RS02730	COG1692	metallophosphoesterase
ACLO_RS02745	COG2226	methyltransferase
ACLO_RS02750	COG1570	exodeoxyribonuclease VII activity
ACLO_RS02765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACLO_RS02775	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ACLO_RS02780	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACLO_RS02795	COG0459	protein refolding
ACLO_RS02805	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACLO_RS02820	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACLO_RS02825	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ACLO_RS02830	COG0352	thiamine-phosphate diphosphorylase activity
ACLO_RS02835	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ACLO_RS02845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACLO_RS02850	COG2264	protein methyltransferase activity
ACLO_RS02855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACLO_RS02860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACLO_RS02875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACLO_RS02890	COG1320	monovalent cation:proton antiporter activity
ACLO_RS02910	COG1007	ATP synthesis coupled electron transport
ACLO_RS02915	COG0651	ATP synthesis coupled electron transport
ACLO_RS02920	COG0651	ATP synthesis coupled electron transport
ACLO_RS02925	COG3706	GGDEF domain
ACLO_RS02930	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACLO_RS02935	COG1090	epimerase
ACLO_RS02940	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ACLO_RS03000	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ACLO_RS03005	COG0732	type I restriction modification DNA specificity domain
ACLO_RS03020	COG3177	Filamentation induced by cAMP protein fic
ACLO_RS03025	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ACLO_RS03060	COG0481	GTPase activity
ACLO_RS03075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACLO_RS03090	COG0482	sulfurtransferase activity
ACLO_RS03095	COG0482	sulfurtransferase activity
ACLO_RS03100	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACLO_RS03105	COG0006	proline dipeptidase activity
ACLO_RS03110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACLO_RS03115	COG0402	S-adenosylhomocysteine deaminase activity
ACLO_RS03120	COG0616	signal peptide processing
ACLO_RS03130	COG0280	phosphate acetyltransferase
ACLO_RS03135	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACLO_RS03145	COG2176	DNA-directed DNA polymerase activity
ACLO_RS03165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACLO_RS03175	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ACLO_RS03185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACLO_RS03195	COG0745	RESPONSE REGULATOR receiver
ACLO_RS03200	COG5002	protein histidine kinase activity
ACLO_RS03245	COG1546	Belongs to the CinA family
ACLO_RS03245	COG1058	Belongs to the CinA family
ACLO_RS03250	COG0579	oxidoreductase
ACLO_RS03255	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACLO_RS03270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACLO_RS03295	COG0714	Associated with various cellular activities
ACLO_RS03300	COG0052	Belongs to the universal ribosomal protein uS2 family
ACLO_RS03305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACLO_RS03310	COG1136	(ABC) transporter
ACLO_RS03320	COG0194	GDP metabolic process
ACLO_RS03325	COG5001	Diguanylate cyclase
ACLO_RS03325	COG5002	protein histidine kinase activity
ACLO_RS03330	COG2217	Heavy metal translocating P-type atpase
ACLO_RS03345	COG4608	Belongs to the ABC transporter superfamily
ACLO_RS03350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACLO_RS03355	COG2078	PFAM AMMECR1 domain protein
ACLO_RS03360	COG1355	regulation of microtubule-based process
ACLO_RS03365	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ACLO_RS03370	COG1121	(ABC) transporter
ACLO_RS03375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACLO_RS03385	COG1283	sodium-dependent phosphate transmembrane transporter activity
ACLO_RS03395	COG2996	Protein conserved in bacteria
ACLO_RS03400	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ACLO_RS03415	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACLO_RS03420	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ACLO_RS03440	COG0210	DNA helicase
ACLO_RS03445	COG0569	domain protein
ACLO_RS03445	COG0475	glutathione-regulated potassium exporter activity
ACLO_RS03450	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACLO_RS03475	COG3258	Cytochrome c
ACLO_RS03490	COG1331	Highly conserved protein containing a thioredoxin domain
ACLO_RS03540	COG0525	valine-tRNA ligase activity
ACLO_RS03550	COG0454	-acetyltransferase
ACLO_RS03560	COG4895	conserved protein (DUF2196)
ACLO_RS03565	COG1047	Peptidyl-prolyl cis-trans
ACLO_RS03570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACLO_RS03590	COG3706	GGDEF domain
ACLO_RS03600	COG2814	Major facilitator Superfamily
ACLO_RS03605	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACLO_RS03625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ACLO_RS03630	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACLO_RS03635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACLO_RS03685	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ACLO_RS03705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACLO_RS03725	COG3706	GGDEF domain
ACLO_RS03735	COG0439	Biotin carboxylase
ACLO_RS03740	COG0840	transmembrane signaling receptor activity
ACLO_RS03745	COG0840	transmembrane signaling receptor activity
ACLO_RS03775	COG2166	iron-sulfur cluster assembly
ACLO_RS03780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACLO_RS03790	COG0396	ATPase activity
ACLO_RS03795	COG0719	Fe-S assembly protein
ACLO_RS03805	COG2906	2 iron, 2 sulfur cluster binding
ACLO_RS03805	COG0822	iron-sulfur transferase activity
ACLO_RS03805	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ACLO_RS03815	COG2239	Acts as a magnesium transporter
ACLO_RS03850	COG0165	Argininosuccinate lyase
ACLO_RS03855	COG0835	chemotaxis
ACLO_RS03855	COG0784	Response regulator, receiver
ACLO_RS03860	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ACLO_RS03865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACLO_RS03870	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACLO_RS03885	COG0556	nucleotide-excision repair
ACLO_RS03920	COG0698	ribose 5-phosphate isomerase
ACLO_RS03925	COG0681	Belongs to the peptidase S26 family
ACLO_RS03930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACLO_RS03935	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ACLO_RS03940	COG0193	aminoacyl-tRNA hydrolase activity
ACLO_RS03955	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACLO_RS03965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACLO_RS03975	COG1758	RNA polymerase activity
ACLO_RS03980	COG0528	UMP kinase activity
ACLO_RS03990	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ACLO_RS03995	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ACLO_RS04000	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACLO_RS04010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACLO_RS04015	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACLO_RS04030	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACLO_RS04040	COG0305	Participates in initiation and elongation during chromosome replication
ACLO_RS04050	COG1793	dna ligase
ACLO_RS04055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACLO_RS04060	COG0133	tryptophan synthase activity
ACLO_RS04070	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACLO_RS04080	COG0848	biopolymer transport protein
ACLO_RS04100	COG1136	(ABC) transporter
ACLO_RS04100	COG0577	efflux transmembrane transporter activity
ACLO_RS04105	COG1136	(ABC) transporter
ACLO_RS04105	COG0577	efflux transmembrane transporter activity
ACLO_RS04125	COG1082	Xylose isomerase domain protein TIM barrel
ACLO_RS04190	COG0735	belongs to the Fur family
ACLO_RS04205	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ACLO_RS04205	COG1918	ferrous iron import across plasma membrane
ACLO_RS04210	COG1918	ferrous iron import across plasma membrane
ACLO_RS04235	COG4774	siderophore transport
ACLO_RS04240	COG3128	pkhd-type hydroxylase
ACLO_RS04250	COG4771	TonB-dependent receptor
ACLO_RS04265	COG2202	Pas domain
ACLO_RS04265	COG1366	Belongs to the anti-sigma-factor antagonist family
ACLO_RS04275	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ACLO_RS04280	COG0585	pseudouridine synthase activity
ACLO_RS04295	COG0632	four-way junction helicase activity
ACLO_RS04300	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACLO_RS04305	COG2267	carboxylic ester hydrolase activity
ACLO_RS04310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACLO_RS04325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACLO_RS04330	COG0051	transcription antitermination factor activity, RNA binding
ACLO_RS04335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACLO_RS04340	COG0088	Forms part of the polypeptide exit tunnel
ACLO_RS04345	COG0089	rRNA binding
ACLO_RS04350	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACLO_RS04355	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACLO_RS04360	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACLO_RS04365	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACLO_RS04370	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACLO_RS04375	COG0255	Belongs to the universal ribosomal protein uL29 family
ACLO_RS04380	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACLO_RS04385	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACLO_RS04390	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACLO_RS04395	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACLO_RS04400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACLO_RS04405	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACLO_RS04410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACLO_RS04415	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACLO_RS04420	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACLO_RS04425	COG0200	Binds to the 23S rRNA
ACLO_RS04430	COG0201	protein transport
ACLO_RS04435	COG0024	Methionine aminopeptidase
ACLO_RS04440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACLO_RS04450	COG1573	uracil-dna glycosylase
ACLO_RS04460	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACLO_RS04475	COG1032	radical SAM domain protein
ACLO_RS04485	COG0563	adenylate kinase activity
ACLO_RS04530	COG0829	nickel cation binding
ACLO_RS04535	COG0832	Belongs to the urease beta subunit family
ACLO_RS04535	COG0831	urea catabolic process
ACLO_RS04540	COG0804	urea catabolic process
ACLO_RS04545	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
ACLO_RS04555	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ACLO_RS04585	COG3706	GGDEF domain
ACLO_RS04590	COG0708	Exodeoxyribonuclease III
ACLO_RS04620	COG0166	Belongs to the GPI family
ACLO_RS04665	COG3123	guanosine phosphorylase activity
ACLO_RS04685	COG0012	GTP binding
ACLO_RS04690	COG2252	PERMEase
ACLO_RS04695	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ACLO_RS04700	COG2363	Small membrane protein
ACLO_RS04710	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ACLO_RS04715	COG2233	PERMEase
ACLO_RS04720	COG1666	GTP binding
ACLO_RS04730	COG0745	RESPONSE REGULATOR receiver
ACLO_RS04735	COG0642	Histidine kinase
ACLO_RS04755	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACLO_RS04760	COG0135	phosphoribosylanthranilate isomerase activity
ACLO_RS04765	COG2176	DNA-directed DNA polymerase activity
ACLO_RS04770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACLO_RS04780	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACLO_RS04785	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACLO_RS04785	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACLO_RS04795	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ACLO_RS04800	COG0727	PFAM Uncharacterised protein family (UPF0153)
ACLO_RS04810	COG0134	indole-3-glycerol-phosphate synthase activity
ACLO_RS04815	COG0583	DNA-binding transcription factor activity
ACLO_RS04820	COG1942	4-Oxalocrotonate Tautomerase
ACLO_RS04830	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ACLO_RS04835	COG0750	zinc metalloprotease
ACLO_RS04840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACLO_RS04845	COG1028	Short-chain dehydrogenase reductase Sdr
ACLO_RS04850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACLO_RS04865	COG0167	dihydroorotate dehydrogenase activity
ACLO_RS04870	COG1132	(ABC) transporter
ACLO_RS04875	COG0728	peptidoglycan biosynthetic process
ACLO_RS04885	COG1592	Rubrerythrin
ACLO_RS04895	COG0530	calcium, potassium:sodium antiporter activity
ACLO_RS04900	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACLO_RS04905	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ACLO_RS04945	COG0552	protein localization to endoplasmic reticulum
ACLO_RS04950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACLO_RS04960	COG1418	mRNA catabolic process
ACLO_RS04965	COG0742	ribosomal rna small subunit methyltransferase
ACLO_RS04970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACLO_RS04980	COG0300	oxidoreductase activity
ACLO_RS04995	COG3258	Cytochrome c
ACLO_RS05010	COG0642	Histidine kinase
ACLO_RS05020	COG0157	Belongs to the NadC ModD family
ACLO_RS05030	COG1610	YqeY-like protein
ACLO_RS05045	COG0428	transporter
ACLO_RS05050	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ACLO_RS05055	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ACLO_RS05060	COG0436	Aminotransferase
ACLO_RS05065	COG1451	nucleotide metabolic process
ACLO_RS05080	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACLO_RS05085	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACLO_RS05085	COG0519	Catalyzes the synthesis of GMP from XMP
ACLO_RS05100	COG2336	PFAM SpoVT AbrB
ACLO_RS05115	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACLO_RS05155	COG0596	Alpha beta hydrolase
ACLO_RS05160	COG1489	DNA binding
ACLO_RS05175	COG1696	Membrane protein involved in D-alanine export
ACLO_RS05180	COG0564	pseudouridine synthase activity
ACLO_RS05185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACLO_RS05195	COG2223	nitrite transmembrane transporter activity
ACLO_RS05215	COG0300	oxidoreductase activity
ACLO_RS05220	COG0519	Catalyzes the synthesis of GMP from XMP
ACLO_RS05220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACLO_RS05280	COG2989	Protein conserved in bacteria
ACLO_RS05285	COG0628	permease
ACLO_RS05290	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ACLO_RS05305	COG4536	flavin adenine dinucleotide binding
ACLO_RS05320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACLO_RS05325	COG1309	transcriptional regulator
ACLO_RS05340	COG0513	Belongs to the DEAD box helicase family
ACLO_RS05350	COG1045	serine acetyltransferase
ACLO_RS05355	COG1166	arginine decarboxylase activity
ACLO_RS05360	COG0124	histidyl-tRNA synthetase
ACLO_RS05365	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACLO_RS05370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACLO_RS05375	COG0163	prenyltransferase activity
ACLO_RS05385	COG0359	binds to the 23S rRNA
ACLO_RS05390	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ACLO_RS05395	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ACLO_RS05405	COG0084	hydrolase, TatD family'
ACLO_RS05415	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACLO_RS05420	COG0131	Imidazoleglycerol-phosphate dehydratase
ACLO_RS05425	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACLO_RS05440	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACLO_RS05445	COG0456	acetyltransferase
ACLO_RS05450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACLO_RS05455	COG3576	pyridoxamine 5-phosphate
ACLO_RS05475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACLO_RS05485	COG2897	thiosulfate sulfurtransferase activity
ACLO_RS05495	COG1338	Plays a role in the flagellum-specific transport system
ACLO_RS05550	COG0849	cell division
ACLO_RS05555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACLO_RS05570	COG0408	coproporphyrinogen oxidase activity
ACLO_RS05580	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACLO_RS05590	COG1193	negative regulation of DNA recombination
ACLO_RS05610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACLO_RS05630	COG1396	sequence-specific DNA binding
ACLO_RS05635	COG1119	ATPase activity
ACLO_RS05650	COG1605	Chorismate mutase
ACLO_RS05650	COG0077	Prephenate dehydratase
ACLO_RS05655	COG2824	Alkylphosphonate utilization operon protein PhnA
ACLO_RS05675	COG1881	PFAM PEBP family protein
ACLO_RS05680	COG0583	DNA-binding transcription factor activity
ACLO_RS05685	COG2855	membrane
ACLO_RS05710	COG1733	regulation of RNA biosynthetic process
ACLO_RS05715	COG2249	NAD(P)H dehydrogenase (quinone) activity
ACLO_RS05730	COG0778	Nitroreductase
ACLO_RS05740	COG5002	protein histidine kinase activity
ACLO_RS05770	COG2198	Histidine kinase
ACLO_RS05770	COG0643	Histidine kinase
ACLO_RS05785	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
ACLO_RS05790	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACLO_RS05800	COG3437	response regulator, receiver
ACLO_RS05800	COG0784	Response regulator, receiver
ACLO_RS05810	COG3040	lipid binding
ACLO_RS05825	COG3046	protein related to deoxyribodipyrimidine photolyase
ACLO_RS05840	COG2200	EAL domain
ACLO_RS05840	COG2199	diguanylate cyclase activity
ACLO_RS05840	COG3287	FIST C domain
ACLO_RS05850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACLO_RS05865	COG3040	lipid binding
ACLO_RS05870	COG2211	Major facilitator Superfamily
ACLO_RS05875	COG0300	oxidoreductase activity
ACLO_RS05885	COG0488	(ABC) transporter
ACLO_RS05890	COG1607	acyl-coa hydrolase
ACLO_RS05895	COG0784	Response regulator, receiver
ACLO_RS05895	COG3437	response regulator, receiver
ACLO_RS05900	COG0840	transmembrane signaling receptor activity
ACLO_RS05905	COG0840	transmembrane signaling receptor activity
ACLO_RS05910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACLO_RS06030	COG0393	Putative heavy-metal-binding
ACLO_RS06090	COG2195	Cleaves the N-terminal amino acid of tripeptides
ACLO_RS06100	COG0745	RESPONSE REGULATOR receiver
ACLO_RS06105	COG1333	cytochrome c biogenesis protein
ACLO_RS06105	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACLO_RS06140	COG0582	viral genome integration into host DNA
ACLO_RS06145	COG0500	methyltransferase
ACLO_RS06150	COG2203	Gaf domain
ACLO_RS06150	COG5001	Diguanylate cyclase
ACLO_RS06150	COG4251	negative regulation of phosphorylation
ACLO_RS06150	COG3706	GGDEF domain
ACLO_RS06155	COG5001	Diguanylate cyclase
ACLO_RS06160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACLO_RS06180	COG0133	tryptophan synthase activity
ACLO_RS06185	COG0484	heat shock protein binding
ACLO_RS06190	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACLO_RS06215	COG0137	argininosuccinate synthase activity
ACLO_RS06225	COG4771	TonB-dependent receptor
ACLO_RS06235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACLO_RS06240	COG0802	atpase or kinase
ACLO_RS06245	COG1137	ATPase activity
ACLO_RS06250	COG3706	GGDEF domain
ACLO_RS06255	COG3287	FIST C domain
ACLO_RS06255	COG2199	diguanylate cyclase activity
ACLO_RS06255	COG2200	EAL domain
ACLO_RS06260	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ACLO_RS06265	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACLO_RS06265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACLO_RS06285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACLO_RS06290	COG2181	nitrate reductase activity
ACLO_RS06290	COG0247	lactate metabolic process
ACLO_RS06300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACLO_RS06330	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ACLO_RS06335	COG0805	protein transport
ACLO_RS06340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACLO_RS06345	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACLO_RS06365	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACLO_RS06375	COG1663	tetraacyldisaccharide 4'-kinase activity
ACLO_RS06385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACLO_RS06390	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACLO_RS06395	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACLO_RS06395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACLO_RS06410	COG0745	RESPONSE REGULATOR receiver
ACLO_RS06415	COG0840	transmembrane signaling receptor activity
ACLO_RS06420	COG0113	porphobilinogen synthase activity
ACLO_RS06425	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACLO_RS06430	COG0357	Ribosomal RNA small subunit methyltransferase G
ACLO_RS06460	COG0745	RESPONSE REGULATOR receiver
ACLO_RS06470	COG0330	HflC and HflK could
ACLO_RS06515	COG0848	biopolymer transport protein
ACLO_RS06530	COG0419	ATPase involved in DNA repair
ACLO_RS06570	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACLO_RS06575	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ACLO_RS06580	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ACLO_RS06585	COG1187	pseudouridine synthase activity
ACLO_RS06620	COG4206	TonB-dependent receptor
ACLO_RS06635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACLO_RS06660	COG0667	Aldo Keto reductase
ACLO_RS06665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACLO_RS06670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACLO_RS06680	COG0281	malic enzyme
ACLO_RS06680	COG0280	phosphate acetyltransferase
ACLO_RS06685	COG0788	formyltetrahydrofolate deformylase activity
ACLO_RS06690	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ACLO_RS06720	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ACLO_RS06725	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ACLO_RS06730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACLO_RS06750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACLO_RS06750	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACLO_RS06760	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ACLO_RS06790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACLO_RS06795	COG0612	Peptidase, M16
ACLO_RS06800	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACLO_RS06805	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACLO_RS06810	COG0287	Prephenate dehydrogenase
ACLO_RS06815	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACLO_RS06830	COG0527	aspartate kinase activity
ACLO_RS06835	COG0494	nUDIX hydrolase
ACLO_RS06840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACLO_RS06845	COG2890	protein-(glutamine-N5) methyltransferase activity
ACLO_RS06850	COG0339	signal peptide processing
ACLO_RS06895	COG0582	viral genome integration into host DNA
ACLO_RS06900	COG2201	protein-glutamate methylesterase activity
ACLO_RS06910	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACLO_RS06915	COG2198	Histidine kinase
ACLO_RS06915	COG0643	Histidine kinase
ACLO_RS06925	COG1185	polyribonucleotide nucleotidyltransferase activity
ACLO_RS06935	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ACLO_RS06955	COG0659	secondary active sulfate transmembrane transporter activity
ACLO_RS06960	COG1160	GTP binding
ACLO_RS06970	COG1674	ftsk spoiiie
ACLO_RS06970	COG1196	nuclear chromosome segregation
ACLO_RS06975	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACLO_RS06980	COG0440	acetolactate synthase activity
ACLO_RS06985	COG0028	Belongs to the TPP enzyme family
ACLO_RS06990	COG5001	Diguanylate cyclase
ACLO_RS06990	COG3300	MHYT domain
ACLO_RS07015	COG2203	Gaf domain
ACLO_RS07015	COG3706	GGDEF domain
ACLO_RS07015	COG4251	negative regulation of phosphorylation
ACLO_RS07015	COG5001	Diguanylate cyclase
ACLO_RS07040	COG0037	tRNA processing
ACLO_RS07065	COG1322	Protein conserved in bacteria
ACLO_RS07070	COG0501	Belongs to the peptidase M48B family
ACLO_RS07080	COG0824	Thioesterase
ACLO_RS07090	COG4191	Histidine kinase
ACLO_RS07095	COG0784	Response regulator, receiver
ACLO_RS07095	COG3437	response regulator, receiver
ACLO_RS07100	COG0840	transmembrane signaling receptor activity
ACLO_RS07105	COG0840	transmembrane signaling receptor activity
ACLO_RS07115	COG0745	RESPONSE REGULATOR receiver
ACLO_RS07125	COG4999	Histidine kinase
ACLO_RS07125	COG3850	Histidine kinase
ACLO_RS07125	COG3437	response regulator, receiver
ACLO_RS07125	COG2205	protein histidine kinase activity
ACLO_RS07130	COG0840	transmembrane signaling receptor activity
ACLO_RS07145	COG2059	Chromate
ACLO_RS07150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACLO_RS07165	COG0640	Transcriptional regulator
ACLO_RS07175	COG0754	glutathionylspermidine amidase activity
ACLO_RS07180	COG4191	Histidine kinase
ACLO_RS07180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACLO_RS07185	COG1879	ABC-type sugar transport system periplasmic component
ACLO_RS07205	COG0653	protein targeting
ACLO_RS07210	COG4591	ABC-type transport system involved in lipoprotein release permease component
ACLO_RS07230	COG0039	L-malate dehydrogenase activity
ACLO_RS07245	COG4865	methylaspartate mutase activity
ACLO_RS07255	COG0318	PFAM AMP-dependent synthetase and ligase
ACLO_RS07285	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACLO_RS07305	COG0275	rRNA processing
ACLO_RS07315	COG0776	regulation of translation
ACLO_RS07330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACLO_RS07330	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ACLO_RS07340	COG2201	protein-glutamate methylesterase activity
ACLO_RS07355	COG0484	heat shock protein binding
ACLO_RS07360	COG0789	Transcriptional regulator
ACLO_RS07365	COG4974	Belongs to the 'phage' integrase family
ACLO_RS07435	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACLO_RS07440	COG1280	lysine exporter protein (LysE YggA)
ACLO_RS07445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACLO_RS07450	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ACLO_RS07460	COG0471	metal ion transport
ACLO_RS07465	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACLO_RS07475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACLO_RS07480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACLO_RS07490	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACLO_RS07495	COG0513	Belongs to the DEAD box helicase family
ACLO_RS07500	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACLO_RS07530	COG3279	Response regulator of the LytR AlgR family
ACLO_RS07590	COG0642	Histidine kinase
ACLO_RS07595	COG0745	RESPONSE REGULATOR receiver
ACLO_RS07615	COG1132	(ABC) transporter
ACLO_RS07620	COG0628	permease
ACLO_RS07630	COG3300	MHYT domain
ACLO_RS07630	COG5001	Diguanylate cyclase
ACLO_RS07635	COG3118	belongs to the thioredoxin family
ACLO_RS07640	COG0450	alkyl hydroperoxide reductase
ACLO_RS07645	COG2205	protein histidine kinase activity
ACLO_RS07645	COG5002	protein histidine kinase activity
ACLO_RS07645	COG0784	Response regulator, receiver
ACLO_RS07655	COG1472	Belongs to the glycosyl hydrolase 3 family
ACLO_RS07680	COG1620	l-lactate permease
ACLO_RS07685	COG0484	heat shock protein binding
ACLO_RS07715	COG2204	response regulator
ACLO_RS07720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACLO_RS07720	COG2198	Histidine kinase
ACLO_RS07720	COG2205	protein histidine kinase activity
ACLO_RS07720	COG0784	Response regulator, receiver
ACLO_RS07730	COG1047	Peptidyl-prolyl cis-trans
ACLO_RS07735	COG0516	GMP reductase activity
ACLO_RS07735	COG0517	IMP dehydrogenase activity
ACLO_RS07740	COG0154	amidase activity
ACLO_RS07745	COG0203	ribosomal protein L17
ACLO_RS07750	COG0202	RNA polymerase activity
ACLO_RS07755	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACLO_RS07760	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACLO_RS07765	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACLO_RS07770	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ACLO_RS07785	COG0473	3-isopropylmalate dehydrogenase activity
ACLO_RS07790	COG0066	3-isopropylmalate dehydratase activity
ACLO_RS07795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACLO_RS07815	COG3123	guanosine phosphorylase activity
ACLO_RS07820	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACLO_RS07845	COG0772	Belongs to the SEDS family
ACLO_RS07850	COG0564	pseudouridine synthase activity
ACLO_RS07855	COG0366	Alpha amylase catalytic
ACLO_RS07855	COG3103	Sh3 type 3 domain protein
ACLO_RS07860	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ACLO_RS07865	COG2884	Cell division ATP-binding protein ftsE
ACLO_RS07880	COG1671	Belongs to the UPF0178 family
ACLO_RS07890	COG0488	(ABC) transporter
ACLO_RS07905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACLO_RS07920	COG2171	N-acyltransferase activity
ACLO_RS07925	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACLO_RS07955	COG0309	Hydrogenase expression formation protein (HypE)
ACLO_RS07980	COG0298	carbon dioxide binding
ACLO_RS07985	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ACLO_RS08005	COG0310	cobalt ion transport
ACLO_RS08015	COG0840	transmembrane signaling receptor activity
ACLO_RS08025	COG2081	HI0933 family
ACLO_RS08040	COG2814	Major facilitator Superfamily
ACLO_RS08050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACLO_RS08050	COG0301	tRNA thio-modification
ACLO_RS08090	COG0517	IMP dehydrogenase activity
ACLO_RS08110	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ACLO_RS08125	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
ACLO_RS08130	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ACLO_RS08135	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ACLO_RS08140	COG3259	Nickel-dependent hydrogenase
ACLO_RS08150	COG1309	transcriptional regulator
ACLO_RS08155	COG1049	propionate catabolic process, 2-methylcitrate cycle
ACLO_RS08165	COG2203	Gaf domain
ACLO_RS08165	COG4251	negative regulation of phosphorylation
ACLO_RS08165	COG5001	Diguanylate cyclase
ACLO_RS08165	COG3706	GGDEF domain
ACLO_RS08180	COG1022	Amp-dependent synthetase and ligase
ACLO_RS08185	COG0183	Belongs to the thiolase family
ACLO_RS08190	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACLO_RS08190	COG1024	Enoyl-CoA hydratase
ACLO_RS08195	COG1960	acyl-CoA dehydrogenase activity
ACLO_RS08270	COG0217	transcriptional regulatory protein
ACLO_RS08275	COG0739	heme binding
ACLO_RS08280	COG2853	Lipoprotein
ACLO_RS08295	COG1611	Belongs to the LOG family
ACLO_RS08300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACLO_RS08325	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ACLO_RS08345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACLO_RS08370	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACLO_RS08385	COG1696	Membrane protein involved in D-alanine export
ACLO_RS08405	COG0513	Belongs to the DEAD box helicase family
ACLO_RS08410	COG1944	ATP diphosphatase activity
ACLO_RS08430	COG0840	transmembrane signaling receptor activity
ACLO_RS08440	COG0328	RNA-DNA hybrid ribonuclease activity
ACLO_RS08460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACLO_RS08470	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACLO_RS08490	COG4662	Binding-protein-dependent transport system inner membrane component
ACLO_RS08495	COG2998	abc-type tungstate transport system, permease component
ACLO_RS08500	COG0303	'Molybdopterin
ACLO_RS08510	COG2005	Transcriptional regulator
ACLO_RS08520	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ACLO_RS08530	COG0437	4 iron, 4 sulfur cluster binding
ACLO_RS08565	COG2204	response regulator
ACLO_RS08605	COG0714	Associated with various cellular activities
ACLO_RS08625	COG2304	oxidoreductase activity
ACLO_RS08645	COG1305	Transglutaminase-like
ACLO_RS08650	COG0709	Synthesizes selenophosphate from selenide and ATP
ACLO_RS08660	COG1921	L-seryl-tRNASec selenium transferase activity
ACLO_RS08690	COG2204	response regulator
ACLO_RS08705	COG2205	protein histidine kinase activity
ACLO_RS08705	COG4999	Histidine kinase
ACLO_RS08705	COG3850	Histidine kinase
ACLO_RS08705	COG3437	response regulator, receiver
ACLO_RS08710	COG3437	response regulator, receiver
ACLO_RS08715	COG4999	Histidine kinase
ACLO_RS08715	COG3850	Histidine kinase
ACLO_RS08715	COG3437	response regulator, receiver
ACLO_RS08715	COG2205	protein histidine kinase activity
ACLO_RS08750	COG5001	Diguanylate cyclase
ACLO_RS08750	COG5002	protein histidine kinase activity
ACLO_RS08770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACLO_RS08775	COG0418	dihydroorotase activity
ACLO_RS08780	COG0720	synthase
ACLO_RS08790	COG1078	dGTPase activity
ACLO_RS08795	COG0259	pyridoxamine-phosphate oxidase activity
ACLO_RS08805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACLO_RS08815	COG0513	Belongs to the DEAD box helicase family
ACLO_RS08840	COG1984	allophanate hydrolase subunit 2
ACLO_RS08850	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ACLO_RS08870	COG0842	Transport permease protein
ACLO_RS08875	COG0842	Transport permease protein
ACLO_RS08875	COG1129	ABC transporter
ACLO_RS08880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACLO_RS08890	COG0306	phosphate transporter
ACLO_RS08905	COG0326	Molecular chaperone. Has ATPase activity
ACLO_RS08910	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ACLO_RS08915	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ACLO_RS08930	COG3437	response regulator, receiver
ACLO_RS08945	COG2995	paraquat-inducible protein a
ACLO_RS08960	COG5001	Diguanylate cyclase
ACLO_RS08960	COG5002	protein histidine kinase activity
ACLO_RS08970	COG2205	protein histidine kinase activity
ACLO_RS08975	COG0745	RESPONSE REGULATOR receiver
ACLO_RS08980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ACLO_RS08985	COG0569	domain protein
ACLO_RS09000	COG2902	Dehydrogenase
ACLO_RS09010	COG4335	DNA alkylation repair
ACLO_RS09020	COG0010	Belongs to the arginase family
ACLO_RS09025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACLO_RS09030	COG2207	Transcriptional regulator
ACLO_RS09035	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ACLO_RS09050	COG1027	Aspartate ammonia-lyase
ACLO_RS09055	COG0745	RESPONSE REGULATOR receiver
ACLO_RS09065	COG1115	amino acid carrier protein
ACLO_RS09070	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACLO_RS09075	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ACLO_RS09080	COG1047	Peptidyl-prolyl cis-trans
ACLO_RS09095	COG2193	ferroxidase activity
ACLO_RS09100	COG0823	Involved in the tonB-independent uptake of proteins
ACLO_RS09110	COG0848	biopolymer transport protein
ACLO_RS09115	COG0811	peptide transport
ACLO_RS09120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACLO_RS09125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACLO_RS09130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACLO_RS09135	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACLO_RS09140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACLO_RS09145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ACLO_RS09155	COG1475	DNA binding
ACLO_RS09160	COG1192	Involved in chromosome partitioning
ACLO_RS09165	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ACLO_RS09165	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ACLO_RS09175	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACLO_RS09180	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACLO_RS09185	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACLO_RS09190	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACLO_RS09195	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACLO_RS09205	COG0358	DNA primase activity
ACLO_RS09215	COG0571	ribonuclease III activity
ACLO_RS09220	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACLO_RS09230	COG0501	Belongs to the peptidase M48B family
ACLO_RS09245	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACLO_RS09255	COG0706	membrane insertase activity
ACLO_RS09260	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACLO_RS09265	COG0594	ribonuclease P activity
ACLO_RS09270	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ACLO_RS09275	COG0542	response to heat
ACLO_RS09290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACLO_RS09305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACLO_RS09310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACLO_RS09315	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACLO_RS09335	COG0784	Response regulator, receiver
ACLO_RS09335	COG2205	protein histidine kinase activity
ACLO_RS09345	COG0745	RESPONSE REGULATOR receiver
ACLO_RS09355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACLO_RS09365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACLO_RS09370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACLO_RS09375	COG0861	Integral membrane protein TerC family
ACLO_RS09380	COG0726	polysaccharide deacetylase
ACLO_RS09385	COG0840	transmembrane signaling receptor activity
ACLO_RS09390	COG0840	transmembrane signaling receptor activity
ACLO_RS09395	COG0840	transmembrane signaling receptor activity
ACLO_RS09400	COG0386	Belongs to the glutathione peroxidase family
ACLO_RS09405	COG3201	nicotinamide mononucleotide transporter
ACLO_RS09415	COG3706	GGDEF domain
ACLO_RS09420	COG0322	excinuclease ABC activity
ACLO_RS09425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACLO_RS09450	COG0138	bifunctional purine biosynthesis protein purh
ACLO_RS09455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACLO_RS09465	COG0739	heme binding
ACLO_RS09480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACLO_RS09485	COG1917	Cupin 2, conserved barrel domain protein
ACLO_RS09495	COG0527	aspartate kinase activity
ACLO_RS09500	COG0302	gtp cyclohydrolase
ACLO_RS09505	COG0598	Magnesium transport protein CorA
ACLO_RS09510	COG1459	type II secretion system
ACLO_RS09515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACLO_RS09530	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACLO_RS09535	COG0606	chelatase, subunit chli
ACLO_RS09545	COG0242	peptide deformylase activity
ACLO_RS09550	COG0740	serine-type endopeptidase activity
ACLO_RS09555	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACLO_RS09560	COG2304	oxidoreductase activity
ACLO_RS09565	COG2326	polyphosphate kinase activity
ACLO_RS09580	COG1773	rubredoxin
ACLO_RS09595	COG0582	viral genome integration into host DNA
ACLO_RS09600	COG0653	protein targeting
ACLO_RS09785	COG4681	YaeQ
ACLO_RS09805	COG0626	cystathionine gamma-synthase activity
ACLO_RS09825	COG0745	RESPONSE REGULATOR receiver
ACLO_RS09830	COG0456	acetyltransferase
ACLO_RS09840	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ACLO_RS09855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACLO_RS09855	COG2111	Na H antiporter
ACLO_RS09860	COG1006	Multisubunit Na H antiporter MnhC subunit
ACLO_RS09865	COG0651	ATP synthesis coupled electron transport
ACLO_RS09870	COG1863	multisubunit Na H antiporter MnhE subunit
ACLO_RS09875	COG2212	antiporter activity
ACLO_RS09885	COG1028	Short-chain dehydrogenase reductase Sdr
ACLO_RS09900	COG0840	transmembrane signaling receptor activity
ACLO_RS09905	COG2200	EAL domain
ACLO_RS09910	COG1116	anion transmembrane transporter activity
ACLO_RS09920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACLO_RS09920	COG1116	anion transmembrane transporter activity
ACLO_RS09925	COG0243	molybdopterin cofactor binding
ACLO_RS09930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACLO_RS09945	COG1858	cytochrome C peroxidase
ACLO_RS09980	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACLO_RS09985	COG0840	transmembrane signaling receptor activity
ACLO_RS10130	COG4974	Belongs to the 'phage' integrase family
ACLO_RS10140	COG4974	Belongs to the 'phage' integrase family
ACLO_RS10145	COG0668	transmembrane transport
ACLO_RS10170	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACLO_RS10185	COG0348	domain, Protein
ACLO_RS10190	COG4191	Histidine kinase
ACLO_RS10195	COG2207	Transcriptional regulator
ACLO_RS10195	COG4753	response regulator
ACLO_RS10235	COG0716	FMN binding
ACLO_RS10250	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ACLO_RS10265	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ACLO_RS10270	COG0159	tryptophan synthase activity
ACLO_RS10275	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACLO_RS10280	COG2255	four-way junction helicase activity
ACLO_RS10285	COG0628	permease
ACLO_RS10295	COG4628	conserved protein (DUF2132)
ACLO_RS10350	COG0731	radical SAM domain protein
ACLO_RS10355	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACLO_RS10365	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ACLO_RS10380	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ACLO_RS10390	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACLO_RS10400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ACLO_RS10405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACLO_RS10410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACLO_RS10410	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACLO_RS10415	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ACLO_RS10420	COG0859	PFAM glycosyl transferase family 9
ACLO_RS10435	COG1216	Glycosyl transferase, family 2
ACLO_RS10450	COG0438	transferase activity, transferring glycosyl groups
ACLO_RS10455	COG1216	Glycosyl transferase, family 2
ACLO_RS10470	COG1216	Glycosyl transferase, family 2
ACLO_RS10515	COG0859	PFAM glycosyl transferase family 9
ACLO_RS10525	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACLO_RS10535	COG0493	'glutamate synthase
ACLO_RS10540	COG0067	glutamate synthase
ACLO_RS10540	COG0069	glutamate synthase activity
ACLO_RS10540	COG0070	glutamate synthase
ACLO_RS10545	COG0584	glycerophosphoryl diester phosphodiesterase
ACLO_RS10610	COG1086	Polysaccharide biosynthesis protein
ACLO_RS10620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACLO_RS10635	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
ACLO_RS10685	COG0463	Glycosyl transferase, family 2
ACLO_RS10700	COG0438	transferase activity, transferring glycosyl groups
ACLO_RS10700	COG4641	Protein conserved in bacteria
ACLO_RS10705	COG0110	maltose O-acetyltransferase activity
ACLO_RS10720	COG0546	phosphoglycolate phosphatase activity
ACLO_RS10725	COG1083	cytidylyl-transferase
ACLO_RS10770	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACLO_RS10775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACLO_RS10780	COG0284	orotidine-5'-phosphate decarboxylase activity
ACLO_RS10815	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ACLO_RS10835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACLO_RS10855	COG1739	Uncharacterized protein family UPF0029
ACLO_RS10860	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ACLO_RS10865	COG0196	riboflavin kinase activity
ACLO_RS10870	COG2226	methyltransferase
ACLO_RS10875	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACLO_RS10885	COG0277	FAD linked oxidase domain protein
ACLO_RS10930	COG0542	response to heat
ACLO_RS10935	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ACLO_RS10940	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACLO_RS10955	COG2030	dehydratase
ACLO_RS10980	COG1970	mechanosensitive ion channel activity
ACLO_RS10985	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACLO_RS11015	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACLO_RS11020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ACLO_RS11025	COG1157	protein secretion by the type III secretion system
ACLO_RS11035	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACLO_RS11055	COG1677	Flagellar hook-basal body complex protein FliE
ACLO_RS11065	COG0455	bacterial-type flagellum organization
ACLO_RS11070	COG1419	protein localization to endoplasmic reticulum
ACLO_RS11095	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ACLO_RS11120	COG1749	Flagellar hook protein flgE
ACLO_RS11125	COG4786	Flagellar basal body rod
ACLO_RS11135	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACLO_RS11145	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACLO_RS11150	COG1766	The M ring may be actively involved in energy transduction
ACLO_RS11155	COG1815	bacterial-type flagellum-dependent cell motility
ACLO_RS11160	COG4786	Flagellar basal body rod
ACLO_RS11170	COG0745	RESPONSE REGULATOR receiver
ACLO_RS11190	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACLO_RS11200	COG0228	four-way junction DNA binding
ACLO_RS11205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACLO_RS11210	COG0564	pseudouridine synthase activity
ACLO_RS11215	COG1519	Transferase
ACLO_RS11225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACLO_RS11230	COG0752	glycyl-tRNA synthetase alpha subunit
ACLO_RS11240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACLO_RS11255	COG0840	transmembrane signaling receptor activity
ACLO_RS11255	COG0840	transmembrane signaling receptor activity
ACLO_RS11260	COG0497	DNA recombination
ACLO_RS11265	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACLO_RS11270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACLO_RS11275	COG0049	tRNA binding
ACLO_RS11280	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACLO_RS11345	COG3706	GGDEF domain
ACLO_RS11375	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACLO_RS11430	COG0582	viral genome integration into host DNA
ACLO_RS11445	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACLO_RS11450	COG0085	RNA polymerase activity
ACLO_RS11455	COG0222	ribosome binding
ACLO_RS11460	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACLO_RS11465	COG0081	regulation of translation
ACLO_RS11470	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACLO_RS11475	COG0250	Participates in transcription elongation, termination and antitermination
ACLO_RS11490	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACLO_RS11495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACLO_RS11520	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACLO_RS11525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACLO_RS11530	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ACLO_RS11535	COG0444	Belongs to the ABC transporter superfamily
ACLO_RS11545	COG0174	glutamine synthetase
ACLO_RS11555	COG2199	diguanylate cyclase activity
ACLO_RS11560	COG0314	molybdopterin synthase activity
ACLO_RS11570	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACLO_RS11585	COG0772	Belongs to the SEDS family
ACLO_RS11595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACLO_RS11635	COG0512	Glutamine amidotransferase of anthranilate synthase
ACLO_RS11640	COG1840	ABC-type Fe3 transport system, periplasmic component
ACLO_RS11645	COG1178	ABC-type Fe3 transport system permease component
ACLO_RS11650	COG3842	ATPase activity
ACLO_RS11690	COG2183	response to ionizing radiation
ACLO_RS11695	COG5001	Diguanylate cyclase
ACLO_RS11695	COG5002	protein histidine kinase activity
ACLO_RS11700	COG0251	oxidation-reduction process
ACLO_RS11715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACLO_RS11720	COG0586	Pfam SNARE associated Golgi protein
ACLO_RS11730	COG0335	large ribosomal subunit rRNA binding
ACLO_RS11735	COG0336	Belongs to the RNA methyltransferase TrmD family
ACLO_RS11745	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACLO_RS11750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACLO_RS11755	COG0356	it plays a direct role in the translocation of protons across the membrane
ACLO_RS11765	COG1074	ATP-dependent DNA helicase activity
ACLO_RS11770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACLO_RS11775	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACLO_RS11785	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ACLO_RS11800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACLO_RS11810	COG0303	'Molybdopterin
ACLO_RS11815	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACLO_RS11825	COG0602	queuosine metabolic process
ACLO_RS11835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACLO_RS11840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACLO_RS11845	COG0825	malonyl-CoA metabolic process
ACLO_RS11850	COG0537	adenosine 5'-monophosphoramidase activity
ACLO_RS11855	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACLO_RS11860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACLO_RS11860	COG0072	phenylalanine-tRNA ligase activity
ACLO_RS11865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACLO_RS11870	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACLO_RS11875	COG0539	negative regulation of cytoplasmic translation
ACLO_RS11875	COG1185	polyribonucleotide nucleotidyltransferase activity
ACLO_RS11880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACLO_RS11885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACLO_RS11890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACLO_RS11890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACLO_RS11895	COG0779	Required for maturation of 30S ribosomal subunits
ACLO_RS11900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACLO_RS11905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACLO_RS11915	COG0083	homoserine kinase activity
ACLO_RS11925	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ACLO_RS11935	COG2404	hydrolase activity, acting on ester bonds
ACLO_RS11940	COG0157	Belongs to the NadC ModD family
ACLO_RS11950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ACLO_RS11960	COG4773	Receptor
ACLO_RS11990	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACLO_RS12030	COG3278	Belongs to the heme-copper respiratory oxidase family
ACLO_RS12035	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACLO_RS12040	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACLO_RS12045	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACLO_RS12050	COG0210	DNA helicase
ACLO_RS12060	COG1242	4 iron, 4 sulfur cluster binding
ACLO_RS12065	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ACLO_RS12070	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACLO_RS12075	COG0492	ferredoxin-NADP+ reductase activity
ACLO_RS12080	COG3118	belongs to the thioredoxin family
ACLO_RS12085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACLO_RS12110	COG0791	NLP P60 protein
ACLO_RS12115	COG0791	NLP P60 protein
ACLO_RS12130	COG0424	maF-like protein
ACLO_RS12140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACLO_RS12145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACLO_RS12150	COG0077	Prephenate dehydratase
ACLO_RS12150	COG1605	Chorismate mutase
ACLO_RS12155	COG0019	diaminopimelate decarboxylase activity
ACLO_RS12160	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACLO_RS12165	COG0149	triose-phosphate isomerase activity
ACLO_RS12170	COG0126	phosphoglycerate kinase activity
ACLO_RS12175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACLO_RS12180	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ACLO_RS12190	COG0018	arginyl-trna synthetase
ACLO_RS12195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACLO_RS12200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACLO_RS12205	COG0204	Acyl-transferase
ACLO_RS12215	COG0047	phosphoribosylformylglycinamidine synthase activity
ACLO_RS12220	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACLO_RS12225	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ACLO_RS12230	COG0793	Belongs to the peptidase S41A family
ACLO_RS12245	COG0585	pseudouridine synthase activity
ACLO_RS12260	COG0577	efflux transmembrane transporter activity
ACLO_RS12260	COG1136	(ABC) transporter
ACLO_RS12290	COG0129	dihydroxy-acid dehydratase activity
ACLO_RS12300	COG0745	RESPONSE REGULATOR receiver
ACLO_RS12305	COG0642	Histidine kinase
ACLO_RS12315	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ACLO_RS12320	COG0702	epimerase
ACLO_RS12335	COG1492	cobalamin metabolic process
ACLO_RS12355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACLO_RS12360	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ACLO_RS12370	COG2095	MarC family integral membrane protein
ACLO_RS12375	COG1083	cytidylyl-transferase
ACLO_RS12375	COG2755	lipolytic protein G-D-S-L family
ACLO_RS12380	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ACLO_RS12395	COG4232	protein-disulfide reductase activity
ACLO_RS12400	COG3118	belongs to the thioredoxin family
ACLO_RS12405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACLO_RS12420	COG0189	ligase activity
ACLO_RS12435	COG2199	diguanylate cyclase activity
ACLO_RS12435	COG2200	EAL domain
ACLO_RS12435	COG3287	FIST C domain
ACLO_RS12440	COG0688	phosphatidylethanolamine metabolic process
ACLO_RS12450	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ACLO_RS12460	COG0443	Heat shock 70 kDa protein
ACLO_RS12465	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACLO_RS12475	COG2358	TRAP transporter, solute receptor (TAXI family
ACLO_RS12485	COG2197	response regulator
ACLO_RS12495	COG0101	tRNA pseudouridine synthase activity
ACLO_RS12510	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACLO_RS12515	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACLO_RS12520	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACLO_RS12530	COG4581	dead DEAH box helicase
ACLO_RS12535	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACLO_RS12565	COG1083	cytidylyl-transferase
ACLO_RS12570	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACLO_RS12580	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ACLO_RS12585	COG1011	Hydrolase
ACLO_RS12600	COG1233	COG1233 Phytoene dehydrogenase and related
ACLO_RS12605	COG2089	acid synthase
ACLO_RS12615	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACLO_RS12635	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACLO_RS12640	COG0148	phosphopyruvate hydratase activity
ACLO_RS12655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACLO_RS12675	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACLO_RS12685	COG1007	ATP synthesis coupled electron transport
ACLO_RS12695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACLO_RS12700	COG0713	ATP synthesis coupled electron transport
ACLO_RS12705	COG0839	Belongs to the complex I subunit 6 family
ACLO_RS12710	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACLO_RS12715	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACLO_RS12735	COG0649	NAD binding
ACLO_RS12740	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACLO_RS12745	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACLO_RS12750	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACLO_RS12755	COG1222	aaa ATPase
ACLO_RS12780	COG0659	secondary active sulfate transmembrane transporter activity
ACLO_RS12785	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ACLO_RS12790	COG1252	NADH dehydrogenase
ACLO_RS12795	COG0733	neurotransmitter:sodium symporter activity
ACLO_RS12805	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACLO_RS12815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACLO_RS12820	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACLO_RS12825	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACLO_RS12845	COG0445	tRNA wobble uridine modification
ACLO_RS12860	COG0348	domain, Protein
ACLO_RS12865	COG0504	CTP synthase activity
ACLO_RS12870	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ACLO_RS12870	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACLO_RS12900	COG0587	DNA-directed DNA polymerase activity
ACLO_RS12905	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ACLO_RS12915	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ACLO_RS12920	COG0315	cyclic pyranopterin monophosphate synthase activity
ACLO_RS12955	COG0670	Belongs to the BI1 family
ACLO_RS12960	COG0352	thiamine-phosphate diphosphorylase activity
ACLO_RS12970	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACLO_RS12980	COG0233	cytoplasmic translational termination
ACLO_RS12985	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACLO_RS12995	COG2814	Major facilitator Superfamily
ACLO_RS13000	COG3264	Mechanosensitive ion channel
ACLO_RS13000	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ACLO_RS13010	COG3022	response to hydroperoxide
ACLO_RS13015	COG3012	SEC-C Motif Domain Protein
ACLO_RS13040	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ACLO_RS13045	COG1012	belongs to the aldehyde dehydrogenase family
ACLO_RS13055	COG1704	LemA family
ACLO_RS13070	COG0546	phosphoglycolate phosphatase activity
ACLO_RS13080	COG0783	Belongs to the Dps family
ACLO_RS13090	COG2814	Major facilitator Superfamily
ACLO_RS13095	COG0840	transmembrane signaling receptor activity
ACLO_RS13140	COG2081	HI0933 family
ACLO_RS13160	COG1959	2 iron, 2 sulfur cluster binding
ACLO_RS13175	COG0175	sulfate reduction
ACLO_RS13180	COG0175	sulfate reduction
ACLO_RS13185	COG2895	sulfate adenylyltransferase (ATP) activity
ACLO_RS13190	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACLO_RS13195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACLO_RS13210	COG1408	metallophosphoesterase
ACLO_RS13215	COG0071	Belongs to the small heat shock protein (HSP20) family
ACLO_RS13230	COG1305	Transglutaminase-like
ACLO_RS13235	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ACLO_RS13240	COG4208	sulfate ABC transporter
ACLO_RS13245	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ACLO_RS13250	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ACLO_RS13255	COG1959	2 iron, 2 sulfur cluster binding
ACLO_RS13275	COG2308	Evidence 4 Homologs of previously reported genes of
ACLO_RS13295	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ACLO_RS13315	COG0745	RESPONSE REGULATOR receiver
ACLO_RS13320	COG0642	Histidine kinase
ACLO_RS13330	COG0425	Belongs to the sulfur carrier protein TusA family
ACLO_RS13335	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ACLO_RS13340	COG2066	Belongs to the glutaminase family
ACLO_RS13345	COG2860	membrane
ACLO_RS13355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACLO_RS13360	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ACLO_RS13370	COG0305	Participates in initiation and elongation during chromosome replication
ACLO_RS13380	COG1475	DNA binding
ACLO_RS13385	COG1192	Involved in chromosome partitioning
ACLO_RS13395	COG4771	TonB-dependent receptor
ACLO_RS13430	COG4771	TonB-dependent receptor
ACLO_RS13445	COG0745	RESPONSE REGULATOR receiver
ACLO_RS13455	COG3550	peptidyl-serine autophosphorylation
ACLO_RS13505	COG0840	transmembrane signaling receptor activity
ACLO_RS13510	COG0840	transmembrane signaling receptor activity
ACLO_RS13515	COG0840	transmembrane signaling receptor activity
ACLO_RS13535	COG0840	transmembrane signaling receptor activity
ACLO_RS13540	COG0840	transmembrane signaling receptor activity
ACLO_RS13550	COG0643	Histidine kinase
ACLO_RS13550	COG2198	Histidine kinase
ACLO_RS13560	COG2203	Gaf domain
ACLO_RS13560	COG4251	negative regulation of phosphorylation
ACLO_RS13560	COG5001	Diguanylate cyclase
ACLO_RS13560	COG3706	GGDEF domain
ACLO_RS13570	COG3328	transposase activity
ACLO_RS13580	COG3328	transposase activity
ACLO_RS13600	COG1518	maintenance of DNA repeat elements
ACLO_RS13615	COG1373	ATPase (AAA superfamily
ACLO_RS13695	COG1337	RAMP superfamily
ACLO_RS13730	COG3550	peptidyl-serine autophosphorylation
ACLO_RS13740	COG1518	maintenance of DNA repeat elements
ACLO_RS13745	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ACLO_RS13785	COG0840	transmembrane signaling receptor activity
ACLO_RS13815	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ACLO_RS13840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACLO_RS13855	COG0745	RESPONSE REGULATOR receiver
ACLO_RS13875	COG4774	siderophore transport
ACLO_RS13885	COG5002	protein histidine kinase activity
ACLO_RS13885	COG5001	Diguanylate cyclase
ACLO_RS13925	COG2207	Transcriptional regulator
ACLO_RS13970	COG2207	Transcriptional regulator
ACLO_RS13970	COG4753	response regulator
ACLO_RS13975	COG3852	Histidine kinase
ACLO_RS13990	COG0114	fumarate hydratase activity
ACLO_RS14030	COG0840	transmembrane signaling receptor activity
ACLO_RS14040	COG0077	Prephenate dehydratase
ACLO_RS14040	COG1605	Chorismate mutase
ACLO_RS14055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ACLO_RS14060	COG2267	carboxylic ester hydrolase activity
ACLO_RS14065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACLO_RS14085	COG4569	acetaldehyde dehydrogenase (acetylating) activity
ACLO_RS14110	COG0543	2 iron, 2 sulfur cluster binding
ACLO_RS14110	COG0633	Ferredoxin
ACLO_RS14130	COG0730	response to heat
ACLO_RS14170	COG2204	response regulator
ACLO_RS14175	COG1028	Short-chain dehydrogenase reductase Sdr
ACLO_RS14180	COG0473	3-isopropylmalate dehydrogenase activity