locus-tag	class	description
ALEK_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ALEK_RS00010	COG0592	DNA-directed DNA polymerase activity
ALEK_RS00015	COG0187	DNA topoisomerase II activity
ALEK_RS00030	COG0492	ferredoxin-NADP+ reductase activity
ALEK_RS00035	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ALEK_RS00060	COG0564	pseudouridine synthase activity
ALEK_RS00065	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ALEK_RS00070	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ALEK_RS00075	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ALEK_RS00135	COG0493	'glutamate synthase
ALEK_RS00170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ALEK_RS00175	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ALEK_RS00190	COG4753	response regulator
ALEK_RS00190	COG2207	Transcriptional regulator
ALEK_RS00195	COG4191	Histidine kinase
ALEK_RS00205	COG0348	domain, Protein
ALEK_RS00210	COG1280	lysine exporter protein (LysE YggA)
ALEK_RS00230	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ALEK_RS00235	COG0604	alcohol dehydrogenase
ALEK_RS00240	COG1733	regulation of RNA biosynthetic process
ALEK_RS00245	COG0390	transport system, permease component
ALEK_RS00265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ALEK_RS00270	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ALEK_RS00295	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ALEK_RS00300	COG1252	NADH dehydrogenase
ALEK_RS00305	COG2030	dehydratase
ALEK_RS00310	COG0659	secondary active sulfate transmembrane transporter activity
ALEK_RS00315	COG1960	acyl-CoA dehydrogenase activity
ALEK_RS00320	COG2181	nitrate reductase activity
ALEK_RS00320	COG0247	lactate metabolic process
ALEK_RS00325	COG2086	electron transfer activity
ALEK_RS00330	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ALEK_RS00335	COG0500	methyltransferase
ALEK_RS00340	COG1250	3-hydroxyacyl-CoA dehydrogenase
ALEK_RS00345	COG2050	protein possibly involved in aromatic compounds catabolism
ALEK_RS00350	COG0824	Thioesterase
ALEK_RS00355	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ALEK_RS00365	COG0183	Belongs to the thiolase family
ALEK_RS00370	COG5002	protein histidine kinase activity
ALEK_RS00380	COG0745	RESPONSE REGULATOR receiver
ALEK_RS00385	COG4191	Histidine kinase
ALEK_RS00390	COG1556	Lactate utilization protein
ALEK_RS00395	COG1139	Iron-sulfur cluster binding protein
ALEK_RS00400	COG0247	lactate metabolic process
ALEK_RS00410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ALEK_RS00410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ALEK_RS00420	COG0439	Biotin carboxylase
ALEK_RS00425	COG0513	Belongs to the DEAD box helicase family
ALEK_RS00435	COG0306	phosphate transporter
ALEK_RS00440	COG0745	RESPONSE REGULATOR receiver
ALEK_RS00450	COG0367	asparagine synthase
ALEK_RS00460	COG0778	Nitroreductase
ALEK_RS00465	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ALEK_RS00470	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ALEK_RS00475	COG1053	succinate dehydrogenase
ALEK_RS00485	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ALEK_RS00495	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ALEK_RS00495	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ALEK_RS00500	COG1187	pseudouridine synthase activity
ALEK_RS00505	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ALEK_RS00505	COG0517	IMP dehydrogenase activity
ALEK_RS00515	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ALEK_RS00520	COG0107	imidazoleglycerol-phosphate synthase activity
ALEK_RS00535	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ALEK_RS00540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ALEK_RS00545	COG0724	RNA recognition motif
ALEK_RS00550	COG0840	transmembrane signaling receptor activity
ALEK_RS00555	COG0745	RESPONSE REGULATOR receiver
ALEK_RS00560	COG0642	Histidine kinase
ALEK_RS00580	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ALEK_RS00590	COG3220	belongs to the UPF0276 family
ALEK_RS00600	COG0534	Mate efflux family protein
ALEK_RS00605	COG0460	homoserine dehydrogenase
ALEK_RS00610	COG0436	Aminotransferase
ALEK_RS00625	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ALEK_RS00630	COG0254	rRNA binding
ALEK_RS00635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ALEK_RS00650	COG2199	diguanylate cyclase activity
ALEK_RS00665	COG0840	transmembrane signaling receptor activity
ALEK_RS00670	COG3706	GGDEF domain
ALEK_RS00675	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ALEK_RS00685	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ALEK_RS00690	COG0237	dephospho-CoA kinase activity
ALEK_RS00695	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ALEK_RS00700	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ALEK_RS00705	COG0840	transmembrane signaling receptor activity
ALEK_RS00710	COG2814	Major facilitator Superfamily
ALEK_RS00715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ALEK_RS00720	COG1741	Belongs to the pirin family
ALEK_RS00730	COG0431	NADPH-dependent FMN reductase
ALEK_RS00735	COG2353	YceI-like domain
ALEK_RS00745	COG1280	lysine exporter protein (LysE YggA)
ALEK_RS00750	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ALEK_RS00755	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ALEK_RS00760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ALEK_RS00770	COG0505	Belongs to the CarA family
ALEK_RS00780	COG1733	regulation of RNA biosynthetic process
ALEK_RS00795	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ALEK_RS00795	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ALEK_RS00805	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ALEK_RS00815	COG0348	domain, Protein
ALEK_RS00815	COG3901	Regulator of nitric oxide reductase transcription
ALEK_RS00820	COG0489	protein tyrosine kinase activity
ALEK_RS00825	COG2249	NAD(P)H dehydrogenase (quinone) activity
ALEK_RS00840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ALEK_RS00840	COG0140	phosphoribosyl-ATP diphosphatase activity
ALEK_RS00870	COG2315	Protein conserved in bacteria
ALEK_RS00875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ALEK_RS00880	COG1121	(ABC) transporter
ALEK_RS00890	COG1410	methionine synthase
ALEK_RS00890	COG0646	methionine synthase
ALEK_RS00915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ALEK_RS00930	COG4773	Receptor
ALEK_RS00935	COG1979	alcohol dehydrogenase
ALEK_RS00940	COG2207	Transcriptional regulator
ALEK_RS00945	COG1979	alcohol dehydrogenase
ALEK_RS00950	COG2207	Transcriptional regulator
ALEK_RS00955	COG0243	molybdopterin cofactor binding
ALEK_RS00965	COG0745	RESPONSE REGULATOR receiver
ALEK_RS00990	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ALEK_RS00995	COG0405	Gamma-glutamyltransferase
ALEK_RS01020	COG1854	S-ribosylhomocysteine lyase activity
ALEK_RS01030	COG2200	EAL domain
ALEK_RS01035	COG3180	Ammonia monooxygenase
ALEK_RS01045	COG0288	reversible hydration of carbon dioxide
ALEK_RS01055	COG0745	RESPONSE REGULATOR receiver
ALEK_RS01075	COG1733	regulation of RNA biosynthetic process
ALEK_RS01080	COG2249	NAD(P)H dehydrogenase (quinone) activity
ALEK_RS01085	COG1013	pyruvate-flavodoxin oxidoreductase activity
ALEK_RS01090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALEK_RS01090	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ALEK_RS01090	COG1013	pyruvate-flavodoxin oxidoreductase activity
ALEK_RS01090	COG0674	pyruvate-flavodoxin oxidoreductase activity
ALEK_RS01100	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ALEK_RS01105	COG0546	phosphoglycolate phosphatase activity
ALEK_RS01115	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ALEK_RS01120	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ALEK_RS01125	COG5002	protein histidine kinase activity
ALEK_RS01130	COG0745	RESPONSE REGULATOR receiver
ALEK_RS01140	COG0704	Plays a role in the regulation of phosphate uptake
ALEK_RS01145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ALEK_RS01150	COG0581	inorganic phosphate transmembrane transporter activity
ALEK_RS01155	COG0573	inorganic phosphate transmembrane transporter activity
ALEK_RS01160	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ALEK_RS01175	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ALEK_RS01180	COG0268	Binds directly to 16S ribosomal RNA
ALEK_RS01185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ALEK_RS01190	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ALEK_RS01195	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ALEK_RS01215	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ALEK_RS01220	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ALEK_RS01225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ALEK_RS01270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ALEK_RS01290	COG0300	oxidoreductase activity
ALEK_RS01290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ALEK_RS01290	COG0318	PFAM AMP-dependent synthetase and ligase
ALEK_RS01290	COG1028	Short-chain dehydrogenase reductase Sdr
ALEK_RS01290	COG3321	synthase
ALEK_RS01305	COG1131	(ABC) transporter
ALEK_RS01330	COG1028	Short-chain dehydrogenase reductase Sdr
ALEK_RS01335	COG2986	histidine ammonia-lyase
ALEK_RS01355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ALEK_RS01360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ALEK_RS01385	COG0575	Belongs to the CDS family
ALEK_RS01390	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ALEK_RS01410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ALEK_RS01420	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ALEK_RS01420	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ALEK_RS01425	COG1324	tolerance protein
ALEK_RS01430	COG2022	thiamine diphosphate biosynthetic process
ALEK_RS01525	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ALEK_RS01555	COG0793	Belongs to the peptidase S41A family
ALEK_RS01560	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ALEK_RS01565	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ALEK_RS01570	COG0047	phosphoribosylformylglycinamidine synthase activity
ALEK_RS01580	COG0204	Acyl-transferase
ALEK_RS01585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ALEK_RS01590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ALEK_RS01595	COG0018	arginyl-trna synthetase
ALEK_RS01605	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ALEK_RS01610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ALEK_RS01615	COG0126	phosphoglycerate kinase activity
ALEK_RS01620	COG0149	triose-phosphate isomerase activity
ALEK_RS01625	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ALEK_RS01630	COG0019	diaminopimelate decarboxylase activity
ALEK_RS01635	COG0077	Prephenate dehydratase
ALEK_RS01635	COG1605	Chorismate mutase
ALEK_RS01640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ALEK_RS01645	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ALEK_RS01655	COG0778	Nitroreductase
ALEK_RS01680	COG1012	belongs to the aldehyde dehydrogenase family
ALEK_RS01690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ALEK_RS01700	COG0243	molybdopterin cofactor binding
ALEK_RS01715	COG1802	Transcriptional regulator
ALEK_RS01720	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ALEK_RS01730	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ALEK_RS01735	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ALEK_RS01745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ALEK_RS01760	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ALEK_RS01765	COG1845	cytochrome c oxidase, subunit III
ALEK_RS01775	COG0424	maF-like protein
ALEK_RS01785	COG0077	Prephenate dehydratase
ALEK_RS01785	COG1605	Chorismate mutase
ALEK_RS01790	COG0473	3-isopropylmalate dehydrogenase activity
ALEK_RS01795	COG1028	Short-chain dehydrogenase reductase Sdr
ALEK_RS01815	COG0398	Pfam SNARE associated Golgi protein
ALEK_RS01825	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ALEK_RS01840	COG0745	RESPONSE REGULATOR receiver
ALEK_RS01880	COG0730	response to heat
ALEK_RS01910	COG4569	acetaldehyde dehydrogenase (acetylating) activity
ALEK_RS01930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ALEK_RS01935	COG2267	carboxylic ester hydrolase activity
ALEK_RS01955	COG0791	NLP P60 protein
ALEK_RS01960	COG0791	NLP P60 protein
ALEK_RS01980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ALEK_RS01985	COG3118	belongs to the thioredoxin family
ALEK_RS01990	COG3118	belongs to the thioredoxin family
ALEK_RS02000	COG4191	Histidine kinase
ALEK_RS02005	COG0745	RESPONSE REGULATOR receiver
ALEK_RS02010	COG1115	amino acid carrier protein
ALEK_RS02015	COG0492	ferredoxin-NADP+ reductase activity
ALEK_RS02020	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ALEK_RS02025	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ALEK_RS02030	COG1242	4 iron, 4 sulfur cluster binding
ALEK_RS02040	COG0210	DNA helicase
ALEK_RS02045	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ALEK_RS02050	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ALEK_RS02055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ALEK_RS02060	COG3278	Belongs to the heme-copper respiratory oxidase family
ALEK_RS02100	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ALEK_RS02120	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ALEK_RS02130	COG0157	Belongs to the NadC ModD family
ALEK_RS02145	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ALEK_RS02155	COG0083	homoserine kinase activity
ALEK_RS02165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ALEK_RS02170	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ALEK_RS02175	COG0779	Required for maturation of 30S ribosomal subunits
ALEK_RS02185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ALEK_RS02190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ALEK_RS02195	COG1185	polyribonucleotide nucleotidyltransferase activity
ALEK_RS02195	COG0539	negative regulation of cytoplasmic translation
ALEK_RS02200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ALEK_RS02205	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ALEK_RS02210	COG0072	phenylalanine-tRNA ligase activity
ALEK_RS02210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ALEK_RS02215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ALEK_RS02220	COG0537	adenosine 5'-monophosphoramidase activity
ALEK_RS02225	COG0825	malonyl-CoA metabolic process
ALEK_RS02230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ALEK_RS02235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ALEK_RS02245	COG0602	queuosine metabolic process
ALEK_RS02255	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ALEK_RS02270	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ALEK_RS02285	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ALEK_RS02295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ALEK_RS02300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ALEK_RS02305	COG3706	GGDEF domain
ALEK_RS02310	COG1074	ATP-dependent DNA helicase activity
ALEK_RS02320	COG0356	it plays a direct role in the translocation of protons across the membrane
ALEK_RS02325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ALEK_RS02330	COG0336	Belongs to the RNA methyltransferase TrmD family
ALEK_RS02335	COG0335	large ribosomal subunit rRNA binding
ALEK_RS02345	COG0586	Pfam SNARE associated Golgi protein
ALEK_RS02355	COG1119	ATPase activity
ALEK_RS02365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ALEK_RS02375	COG2423	ornithine cyclodeaminase activity
ALEK_RS02380	COG3938	Belongs to the proline racemase family
ALEK_RS02385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ALEK_RS02390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALEK_RS02395	COG4215	(ABC) transporter
ALEK_RS02400	COG0765	amino acid transport
ALEK_RS02405	COG1126	abc transporter atp-binding protein
ALEK_RS02410	COG4948	Mandelate Racemase Muconate Lactonizing
ALEK_RS02465	COG0410	ABC transporter
ALEK_RS02470	COG1012	belongs to the aldehyde dehydrogenase family
ALEK_RS02480	COG0840	transmembrane signaling receptor activity
ALEK_RS02520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ALEK_RS02540	COG2885	chlorophyll binding
ALEK_RS02550	COG0745	RESPONSE REGULATOR receiver
ALEK_RS02580	COG2197	response regulator
ALEK_RS02600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ALEK_RS02625	COG1648	precorrin-2 dehydrogenase activity
ALEK_RS02625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ALEK_RS02635	COG0535	radical SAM domain protein
ALEK_RS02670	COG3256	nitric oxide reductase
ALEK_RS02685	COG4753	response regulator
ALEK_RS02685	COG2207	Transcriptional regulator
ALEK_RS02700	COG4773	Receptor
ALEK_RS02705	COG5002	protein histidine kinase activity
ALEK_RS02765	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ALEK_RS02770	COG0848	biopolymer transport protein
ALEK_RS02775	COG0811	peptide transport
ALEK_RS02780	COG0811	peptide transport
ALEK_RS02800	COG4774	siderophore transport
ALEK_RS02800	COG1629	transport
ALEK_RS02805	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ALEK_RS02820	COG0604	alcohol dehydrogenase
ALEK_RS02855	COG3043	anaerobic respiration
ALEK_RS02860	COG0348	domain, Protein
ALEK_RS02865	COG0437	4 iron, 4 sulfur cluster binding
ALEK_RS02870	COG0243	molybdopterin cofactor binding
ALEK_RS02880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ALEK_RS02880	COG1648	precorrin-2 dehydrogenase activity
ALEK_RS02895	COG1760	l-serine dehydratase
ALEK_RS02900	COG1126	abc transporter atp-binding protein
ALEK_RS02905	COG0765	amino acid transport
ALEK_RS02910	COG4597	amino acid ABC transporter
ALEK_RS02915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALEK_RS02920	COG1648	precorrin-2 dehydrogenase activity
ALEK_RS02920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ALEK_RS02935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ALEK_RS02940	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ALEK_RS02945	COG3287	FIST C domain
ALEK_RS02945	COG2200	EAL domain
ALEK_RS02945	COG2199	diguanylate cyclase activity
ALEK_RS02960	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ALEK_RS02970	COG2404	hydrolase activity, acting on ester bonds
ALEK_RS02975	COG1832	CoA-binding protein
ALEK_RS02980	COG0642	Histidine kinase
ALEK_RS02985	COG0745	RESPONSE REGULATOR receiver
ALEK_RS02990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ALEK_RS02995	COG0191	fructose-bisphosphate aldolase activity
ALEK_RS03010	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ALEK_RS03030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ALEK_RS03075	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ALEK_RS03090	COG0535	radical SAM domain protein
ALEK_RS03100	COG0745	RESPONSE REGULATOR receiver
ALEK_RS03105	COG0784	Response regulator, receiver
ALEK_RS03105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALEK_RS03105	COG2198	Histidine kinase
ALEK_RS03105	COG2205	protein histidine kinase activity
ALEK_RS03110	COG1012	belongs to the aldehyde dehydrogenase family
ALEK_RS03120	COG0848	biopolymer transport protein
ALEK_RS03125	COG0811	peptide transport
ALEK_RS03140	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ALEK_RS03145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ALEK_RS03155	COG0142	geranyltranstransferase activity
ALEK_RS03160	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ALEK_RS03165	COG0442	prolyl-tRNA aminoacylation
ALEK_RS03170	COG0668	transmembrane transport
ALEK_RS03175	COG0617	tRNA 3'-terminal CCA addition
ALEK_RS03180	COG0668	transmembrane transport
ALEK_RS03185	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ALEK_RS03190	COG1862	Preprotein translocase
ALEK_RS03195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ALEK_RS03200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ALEK_RS03225	COG0495	leucyl-tRNA aminoacylation
ALEK_RS03235	COG0285	dihydrofolate synthase activity
ALEK_RS03240	COG0739	heme binding
ALEK_RS03250	COG0513	Belongs to the DEAD box helicase family
ALEK_RS03265	COG0745	RESPONSE REGULATOR receiver
ALEK_RS03315	COG4399	Belongs to the UPF0754 family
ALEK_RS03320	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ALEK_RS03340	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ALEK_RS03340	COG0140	phosphoribosyl-ATP diphosphatase activity
ALEK_RS03345	COG0418	dihydroorotase activity
ALEK_RS03350	COG0745	RESPONSE REGULATOR receiver
ALEK_RS03355	COG5002	protein histidine kinase activity
ALEK_RS03365	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ALEK_RS03370	COG2816	NAD+ diphosphatase activity
ALEK_RS03385	COG2081	HI0933 family
ALEK_RS03395	COG4251	negative regulation of phosphorylation
ALEK_RS03395	COG5001	Diguanylate cyclase
ALEK_RS03395	COG2203	Gaf domain
ALEK_RS03395	COG3706	GGDEF domain
ALEK_RS03410	COG1999	signal sequence binding
ALEK_RS03420	COG0745	RESPONSE REGULATOR receiver
ALEK_RS03425	COG0642	Histidine kinase
ALEK_RS03430	COG2081	HI0933 family
ALEK_RS03435	COG1692	metallophosphoesterase
ALEK_RS03455	COG2226	methyltransferase
ALEK_RS03460	COG1570	exodeoxyribonuclease VII activity
ALEK_RS03465	COG0835	chemotaxis
ALEK_RS03470	COG0745	RESPONSE REGULATOR receiver
ALEK_RS03480	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ALEK_RS03490	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ALEK_RS03495	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ALEK_RS03505	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ALEK_RS03510	COG0459	protein refolding
ALEK_RS03520	COG2207	Transcriptional regulator
ALEK_RS03535	COG2201	protein-glutamate methylesterase activity
ALEK_RS03550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ALEK_RS03555	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ALEK_RS03560	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ALEK_RS03565	COG0352	thiamine-phosphate diphosphorylase activity
ALEK_RS03570	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ALEK_RS03585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ALEK_RS03590	COG2264	protein methyltransferase activity
ALEK_RS03595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ALEK_RS03605	COG5001	Diguanylate cyclase
ALEK_RS03605	COG4251	negative regulation of phosphorylation
ALEK_RS03605	COG3706	GGDEF domain
ALEK_RS03605	COG2203	Gaf domain
ALEK_RS03610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ALEK_RS03630	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ALEK_RS03650	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ALEK_RS03660	COG1090	epimerase
ALEK_RS03665	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ALEK_RS03675	COG0784	Response regulator, receiver
ALEK_RS03675	COG3437	response regulator, receiver
ALEK_RS03685	COG0481	GTPase activity
ALEK_RS03690	COG2885	chlorophyll binding
ALEK_RS03705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ALEK_RS03710	COG0482	sulfurtransferase activity
ALEK_RS03715	COG0482	sulfurtransferase activity
ALEK_RS03720	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ALEK_RS03725	COG0006	proline dipeptidase activity
ALEK_RS03730	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ALEK_RS03735	COG0402	S-adenosylhomocysteine deaminase activity
ALEK_RS03740	COG0616	signal peptide processing
ALEK_RS03745	COG0513	Belongs to the DEAD box helicase family
ALEK_RS03755	COG0280	phosphate acetyltransferase
ALEK_RS03760	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ALEK_RS03765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ALEK_RS03785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ALEK_RS03805	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ALEK_RS03815	COG0745	RESPONSE REGULATOR receiver
ALEK_RS03820	COG5002	protein histidine kinase activity
ALEK_RS03925	COG1546	Belongs to the CinA family
ALEK_RS03925	COG1058	Belongs to the CinA family
ALEK_RS03930	COG0579	oxidoreductase
ALEK_RS03935	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ALEK_RS03950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ALEK_RS03975	COG0714	Associated with various cellular activities
ALEK_RS03985	COG0745	RESPONSE REGULATOR receiver
ALEK_RS04000	COG0052	Belongs to the universal ribosomal protein uS2 family
ALEK_RS04005	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ALEK_RS04010	COG1136	(ABC) transporter
ALEK_RS04020	COG0194	GDP metabolic process
ALEK_RS04025	COG5001	Diguanylate cyclase
ALEK_RS04025	COG5002	protein histidine kinase activity
ALEK_RS04030	COG2217	Heavy metal translocating P-type atpase
ALEK_RS04050	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ALEK_RS04065	COG1355	regulation of microtubule-based process
ALEK_RS04070	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ALEK_RS04075	COG1121	(ABC) transporter
ALEK_RS04080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ALEK_RS04085	COG2996	Protein conserved in bacteria
ALEK_RS04090	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ALEK_RS04100	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ALEK_RS04105	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ALEK_RS04110	COG0210	DNA helicase
ALEK_RS04120	COG0525	valine-tRNA ligase activity
ALEK_RS04130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ALEK_RS04145	COG2814	Major facilitator Superfamily
ALEK_RS04150	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ALEK_RS04170	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ALEK_RS04175	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ALEK_RS04180	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ALEK_RS04195	COG1917	Cupin 2, conserved barrel domain protein
ALEK_RS04195	COG2207	Transcriptional regulator
ALEK_RS04225	COG0840	transmembrane signaling receptor activity
ALEK_RS04230	COG0668	transmembrane transport
ALEK_RS04270	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ALEK_RS04275	COG0840	transmembrane signaling receptor activity
ALEK_RS04305	COG1858	cytochrome C peroxidase
ALEK_RS04315	COG1028	Short-chain dehydrogenase reductase Sdr
ALEK_RS04325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ALEK_RS04340	COG1301	dicarboxylic acid transport
ALEK_RS04355	COG1917	Cupin 2, conserved barrel domain protein
ALEK_RS04355	COG2207	Transcriptional regulator
ALEK_RS04360	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ALEK_RS04385	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ALEK_RS04405	COG0626	cystathionine gamma-synthase activity
ALEK_RS04440	COG0585	pseudouridine synthase activity
ALEK_RS04450	COG3118	belongs to the thioredoxin family
ALEK_RS04455	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ALEK_RS04500	COG0432	Pfam Uncharacterised protein family UPF0047
ALEK_RS04530	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ALEK_RS04535	COG2056	Na+-H+ antiporter family
ALEK_RS04545	COG3287	FIST C domain
ALEK_RS04545	COG2200	EAL domain
ALEK_RS04545	COG2199	diguanylate cyclase activity
ALEK_RS04550	COG2151	metal-sulfur cluster biosynthetic enzyme
ALEK_RS04555	COG2166	iron-sulfur cluster assembly
ALEK_RS04560	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ALEK_RS04570	COG0396	ATPase activity
ALEK_RS04575	COG0719	Fe-S assembly protein
ALEK_RS04580	COG0765	amino acid transport
ALEK_RS04590	COG1104	cysteine desulfurase activity
ALEK_RS04620	COG0165	Argininosuccinate lyase
ALEK_RS04625	COG0784	Response regulator, receiver
ALEK_RS04625	COG0835	chemotaxis
ALEK_RS04630	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ALEK_RS04635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ALEK_RS04640	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ALEK_RS04655	COG0556	nucleotide-excision repair
ALEK_RS04660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ALEK_RS04665	COG1234	tRNA 3'-trailer cleavage
ALEK_RS04685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ALEK_RS04705	COG0698	ribose 5-phosphate isomerase
ALEK_RS04710	COG0681	Belongs to the peptidase S26 family
ALEK_RS04715	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ALEK_RS04720	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ALEK_RS04725	COG0193	aminoacyl-tRNA hydrolase activity
ALEK_RS04740	COG0860	N-Acetylmuramoyl-L-alanine amidase
ALEK_RS04750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ALEK_RS04760	COG1758	RNA polymerase activity
ALEK_RS04765	COG0528	UMP kinase activity
ALEK_RS04775	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ALEK_RS04780	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ALEK_RS04785	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ALEK_RS04795	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ALEK_RS04800	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ALEK_RS04810	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ALEK_RS04815	COG0305	Participates in initiation and elongation during chromosome replication
ALEK_RS04825	COG1793	dna ligase
ALEK_RS04860	COG0166	Belongs to the GPI family
ALEK_RS04865	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ALEK_RS04870	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ALEK_RS04880	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ALEK_RS04885	COG2089	acid synthase
ALEK_RS04895	COG0107	imidazoleglycerol-phosphate synthase activity
ALEK_RS04925	COG2089	acid synthase
ALEK_RS04930	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ALEK_RS04960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ALEK_RS05010	COG1063	alcohol dehydrogenase
ALEK_RS05025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ALEK_RS05050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ALEK_RS05055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ALEK_RS05060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ALEK_RS05065	COG0133	tryptophan synthase activity
ALEK_RS05075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ALEK_RS05080	COG0243	molybdopterin cofactor binding
ALEK_RS05085	COG3043	anaerobic respiration
ALEK_RS05090	COG3043	anaerobic respiration
ALEK_RS05100	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ALEK_RS05105	COG0732	type I restriction modification DNA specificity domain
ALEK_RS05130	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ALEK_RS05205	COG0012	GTP binding
ALEK_RS05230	COG3123	guanosine phosphorylase activity
ALEK_RS05245	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ALEK_RS05250	COG0585	pseudouridine synthase activity
ALEK_RS05260	COG0840	transmembrane signaling receptor activity
ALEK_RS05265	COG0632	four-way junction helicase activity
ALEK_RS05270	COG1181	Belongs to the D-alanine--D-alanine ligase family
ALEK_RS05280	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ALEK_RS05340	COG2207	Transcriptional regulator
ALEK_RS05350	COG0051	transcription antitermination factor activity, RNA binding
ALEK_RS05355	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ALEK_RS05360	COG0088	Forms part of the polypeptide exit tunnel
ALEK_RS05365	COG0089	rRNA binding
ALEK_RS05370	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ALEK_RS05375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ALEK_RS05380	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ALEK_RS05385	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ALEK_RS05390	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ALEK_RS05395	COG0255	Belongs to the universal ribosomal protein uL29 family
ALEK_RS05400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ALEK_RS05405	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ALEK_RS05410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ALEK_RS05415	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ALEK_RS05420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ALEK_RS05425	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ALEK_RS05430	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ALEK_RS05435	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ALEK_RS05440	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ALEK_RS05445	COG0200	Binds to the 23S rRNA
ALEK_RS05450	COG0201	protein transport
ALEK_RS05455	COG0024	Methionine aminopeptidase
ALEK_RS05460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ALEK_RS05470	COG1573	uracil-dna glycosylase
ALEK_RS05480	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ALEK_RS05495	COG1032	radical SAM domain protein
ALEK_RS05500	COG0563	adenylate kinase activity
ALEK_RS05505	COG0840	transmembrane signaling receptor activity
ALEK_RS05520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ALEK_RS05525	COG0322	excinuclease ABC activity
ALEK_RS05550	COG0386	Belongs to the glutathione peroxidase family
ALEK_RS05555	COG3706	GGDEF domain
ALEK_RS05580	COG1620	l-lactate permease
ALEK_RS05590	COG3852	Histidine kinase
ALEK_RS05625	COG0840	transmembrane signaling receptor activity
ALEK_RS05625	COG0840	transmembrane signaling receptor activity
ALEK_RS05640	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ALEK_RS05645	COG1472	Belongs to the glycosyl hydrolase 3 family
ALEK_RS05675	COG0708	Exodeoxyribonuclease III
ALEK_RS05680	COG1309	transcriptional regulator
ALEK_RS05715	COG2271	Major facilitator Superfamily
ALEK_RS05740	COG0745	RESPONSE REGULATOR receiver
ALEK_RS05785	COG0579	oxidoreductase
ALEK_RS05790	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ALEK_RS05795	COG2169	Transcriptional regulator
ALEK_RS05795	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ALEK_RS05805	COG1115	amino acid carrier protein
ALEK_RS05820	COG0745	RESPONSE REGULATOR receiver
ALEK_RS05825	COG1027	Aspartate ammonia-lyase
ALEK_RS05835	COG1528	Iron-storage protein
ALEK_RS05845	COG4191	Histidine kinase
ALEK_RS05845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALEK_RS05855	COG5001	Diguanylate cyclase
ALEK_RS05855	COG3300	MHYT domain
ALEK_RS05865	COG1227	inorganic diphosphatase activity
ALEK_RS05875	COG4335	DNA alkylation repair
ALEK_RS05880	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ALEK_RS05910	COG2995	paraquat-inducible protein a
ALEK_RS05915	COG3008	intermembrane lipid transfer
ALEK_RS05920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ALEK_RS05925	COG4175	Glycine betaine
ALEK_RS05930	COG4176	ABC-type proline glycine betaine transport system permease component
ALEK_RS05935	COG2113	Glycine betaine
ALEK_RS05945	COG2113	Glycine betaine
ALEK_RS05955	COG1509	lysine 2,3-aminomutase activity
ALEK_RS05970	COG0702	epimerase
ALEK_RS05985	COG0326	Molecular chaperone. Has ATPase activity
ALEK_RS06010	COG0583	DNA-binding transcription factor activity
ALEK_RS06030	COG0840	transmembrane signaling receptor activity
ALEK_RS06035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ALEK_RS06045	COG0840	transmembrane signaling receptor activity
ALEK_RS06090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ALEK_RS06095	COG0745	RESPONSE REGULATOR receiver
ALEK_RS06115	COG0840	transmembrane signaling receptor activity
ALEK_RS06130	COG0745	RESPONSE REGULATOR receiver
ALEK_RS06135	COG0642	Histidine kinase
ALEK_RS06140	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ALEK_RS06165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ALEK_RS06190	COG1611	Belongs to the LOG family
ALEK_RS06200	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ALEK_RS06205	COG2207	Transcriptional regulator
ALEK_RS06205	COG4753	response regulator
ALEK_RS06210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ALEK_RS06230	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ALEK_RS06240	COG1984	allophanate hydrolase subunit 2
ALEK_RS06250	COG2200	EAL domain
ALEK_RS06250	COG3287	FIST C domain
ALEK_RS06250	COG2199	diguanylate cyclase activity
ALEK_RS06265	COG0840	transmembrane signaling receptor activity
ALEK_RS06270	COG0513	Belongs to the DEAD box helicase family
ALEK_RS06280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ALEK_RS06290	COG4771	TonB-dependent receptor
ALEK_RS06295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ALEK_RS06300	COG1116	anion transmembrane transporter activity
ALEK_RS06325	COG4771	TonB-dependent receptor
ALEK_RS06330	COG0784	Response regulator, receiver
ALEK_RS06340	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ALEK_RS06350	COG0840	transmembrane signaling receptor activity
ALEK_RS06355	COG0259	pyridoxamine-phosphate oxidase activity
ALEK_RS06360	COG3287	FIST C domain
ALEK_RS06360	COG2200	EAL domain
ALEK_RS06360	COG2199	diguanylate cyclase activity
ALEK_RS06370	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ALEK_RS06380	COG2201	protein-glutamate methylesterase activity
ALEK_RS06390	COG2200	EAL domain
ALEK_RS06390	COG2199	diguanylate cyclase activity
ALEK_RS06390	COG3287	FIST C domain
ALEK_RS06395	COG0745	RESPONSE REGULATOR receiver
ALEK_RS06405	COG0110	maltose O-acetyltransferase activity
ALEK_RS06410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ALEK_RS06420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ALEK_RS06435	COG2205	protein histidine kinase activity
ALEK_RS06435	COG5002	protein histidine kinase activity
ALEK_RS06435	COG0784	Response regulator, receiver
ALEK_RS06510	COG1921	L-seryl-tRNASec selenium transferase activity
ALEK_RS06530	COG0709	Synthesizes selenophosphate from selenide and ATP
ALEK_RS06535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALEK_RS06535	COG4191	Histidine kinase
ALEK_RS06540	COG3437	response regulator, receiver
ALEK_RS06540	COG0784	Response regulator, receiver
ALEK_RS06545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALEK_RS06545	COG4191	Histidine kinase
ALEK_RS06550	COG0784	Response regulator, receiver
ALEK_RS06550	COG3437	response regulator, receiver
ALEK_RS06555	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ALEK_RS06560	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ALEK_RS06565	COG3639	organic phosphonate transmembrane transporter activity
ALEK_RS06585	COG2204	response regulator
ALEK_RS06615	COG0243	molybdopterin cofactor binding
ALEK_RS06620	COG3383	formate dehydrogenase (NAD+) activity
ALEK_RS06620	COG0243	molybdopterin cofactor binding
ALEK_RS06625	COG0437	4 iron, 4 sulfur cluster binding
ALEK_RS06635	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ALEK_RS06660	COG2998	abc-type tungstate transport system, permease component
ALEK_RS06665	COG4662	Binding-protein-dependent transport system inner membrane component
ALEK_RS06675	COG3041	Addiction module toxin RelE StbE family
ALEK_RS06680	COG3077	Addiction module antitoxin, RelB DinJ family
ALEK_RS06725	COG1187	pseudouridine synthase activity
ALEK_RS06740	COG4232	protein-disulfide reductase activity
ALEK_RS06805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ALEK_RS06840	COG0251	oxidation-reduction process
ALEK_RS06845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ALEK_RS06850	COG1115	amino acid carrier protein
ALEK_RS06855	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ALEK_RS06860	COG1280	lysine exporter protein (LysE YggA)
ALEK_RS06885	COG0745	RESPONSE REGULATOR receiver
ALEK_RS06895	COG0328	RNA-DNA hybrid ribonuclease activity
ALEK_RS06930	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ALEK_RS06960	COG0716	FMN binding
ALEK_RS06970	COG2201	protein-glutamate methylesterase activity
ALEK_RS06985	COG0784	Response regulator, receiver
ALEK_RS06985	COG0835	chemotaxis
ALEK_RS06990	COG0835	chemotaxis
ALEK_RS06995	COG0840	transmembrane signaling receptor activity
ALEK_RS07000	COG0840	transmembrane signaling receptor activity
ALEK_RS07005	COG2198	Histidine kinase
ALEK_RS07005	COG0643	Histidine kinase
ALEK_RS07015	COG2201	protein-glutamate methylesterase activity
ALEK_RS07020	COG0745	RESPONSE REGULATOR receiver
ALEK_RS07035	COG2204	response regulator
ALEK_RS07040	COG3287	FIST C domain
ALEK_RS07040	COG2200	EAL domain
ALEK_RS07040	COG2199	diguanylate cyclase activity
ALEK_RS07055	COG2204	response regulator
ALEK_RS07100	COG3706	GGDEF domain
ALEK_RS07110	COG2885	chlorophyll binding
ALEK_RS07115	COG0693	protein deglycase activity
ALEK_RS07120	COG1414	Transcriptional regulator
ALEK_RS07135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ALEK_RS07155	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ALEK_RS07160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ALEK_RS07160	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ALEK_RS07185	COG0436	Aminotransferase
ALEK_RS07195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ALEK_RS07220	COG2853	Lipoprotein
ALEK_RS07225	COG0739	heme binding
ALEK_RS07230	COG1067	ATP-dependent peptidase activity
ALEK_RS07235	COG1027	Aspartate ammonia-lyase
ALEK_RS07240	COG0217	transcriptional regulatory protein
ALEK_RS07285	COG1477	protein flavinylation
ALEK_RS07290	COG4783	chaperone-mediated protein folding
ALEK_RS07305	COG1250	3-hydroxyacyl-CoA dehydrogenase
ALEK_RS07305	COG1024	Enoyl-CoA hydratase
ALEK_RS07310	COG0183	Belongs to the thiolase family
ALEK_RS07315	COG1022	Amp-dependent synthetase and ligase
ALEK_RS07320	COG0697	spore germination
ALEK_RS07330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ALEK_RS07335	COG0242	peptide deformylase activity
ALEK_RS07345	COG0114	fumarate hydratase activity
ALEK_RS07360	COG1012	belongs to the aldehyde dehydrogenase family
ALEK_RS07385	COG1049	propionate catabolic process, 2-methylcitrate cycle
ALEK_RS07395	COG0564	pseudouridine synthase activity
ALEK_RS07420	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ALEK_RS07425	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ALEK_RS07455	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ALEK_RS07460	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ALEK_RS07465	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ALEK_RS07470	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
ALEK_RS07475	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ALEK_RS07480	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ALEK_RS07485	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ALEK_RS07495	COG0778	Nitroreductase
ALEK_RS07530	COG0733	neurotransmitter:sodium symporter activity
ALEK_RS07535	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ALEK_RS07540	COG2894	cell division
ALEK_RS07545	COG0850	regulation of cytokinetic process
ALEK_RS07550	COG0513	Belongs to the DEAD box helicase family
ALEK_RS07565	COG1858	cytochrome C peroxidase
ALEK_RS07570	COG0300	oxidoreductase activity
ALEK_RS07580	COG0300	oxidoreductase activity
ALEK_RS07590	COG2814	Major facilitator Superfamily
ALEK_RS07600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALEK_RS07600	COG4191	Histidine kinase
ALEK_RS07615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ALEK_RS07640	COG0840	transmembrane signaling receptor activity
ALEK_RS07645	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ALEK_RS07650	COG0298	carbon dioxide binding
ALEK_RS07655	COG0409	Hydrogenase expression formation protein
ALEK_RS07660	COG0309	Hydrogenase expression formation protein (HypE)
ALEK_RS07665	COG1024	Enoyl-CoA hydratase
ALEK_RS07665	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ALEK_RS07670	COG0375	protein maturation
ALEK_RS07710	COG2095	MarC family integral membrane protein
ALEK_RS07735	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ALEK_RS07745	COG0330	HflC and HflK could
ALEK_RS07750	COG2171	N-acyltransferase activity
ALEK_RS07760	COG0488	(ABC) transporter
ALEK_RS07770	COG2076	Multidrug Resistance protein
ALEK_RS07785	COG1584	GPR1 FUN34 yaaH family protein
ALEK_RS07800	COG2884	Cell division ATP-binding protein ftsE
ALEK_RS07805	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ALEK_RS07815	COG0564	pseudouridine synthase activity
ALEK_RS07820	COG0772	Belongs to the SEDS family
ALEK_RS07825	COG0010	Belongs to the arginase family
ALEK_RS07845	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ALEK_RS07850	COG3123	guanosine phosphorylase activity
ALEK_RS07870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ALEK_RS07875	COG0066	3-isopropylmalate dehydratase activity
ALEK_RS07880	COG0473	3-isopropylmalate dehydrogenase activity
ALEK_RS07895	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ALEK_RS07900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ALEK_RS07905	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ALEK_RS07910	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ALEK_RS07915	COG0202	RNA polymerase activity
ALEK_RS07920	COG0203	ribosomal protein L17
ALEK_RS07925	COG0154	amidase activity
ALEK_RS07930	COG0517	IMP dehydrogenase activity
ALEK_RS07930	COG0516	GMP reductase activity
ALEK_RS07975	COG0563	adenylate kinase activity
ALEK_RS08000	COG1047	Peptidyl-prolyl cis-trans
ALEK_RS08020	COG1047	Peptidyl-prolyl cis-trans
ALEK_RS08030	COG2391	methyltransferase activity
ALEK_RS08045	COG1280	lysine exporter protein (LysE YggA)
ALEK_RS08050	COG1280	lysine exporter protein (LysE YggA)
ALEK_RS08065	COG4772	TonB-dependent receptor
ALEK_RS08085	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ALEK_RS08095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ALEK_RS08105	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ALEK_RS08110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ALEK_RS08135	COG2274	protein secretion by the type I secretion system
ALEK_RS08185	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ALEK_RS08195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ALEK_RS08200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ALEK_RS08210	COG0521	Mo-molybdopterin cofactor biosynthetic process
ALEK_RS08215	COG0471	metal ion transport
ALEK_RS08220	COG1193	negative regulation of DNA recombination
ALEK_RS08240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ALEK_RS08255	COG0456	acetyltransferase
ALEK_RS08260	COG1742	UPF0060 membrane protein
ALEK_RS08275	COG4977	sequence-specific DNA binding
ALEK_RS08285	COG2824	Alkylphosphonate utilization operon protein PhnA
ALEK_RS08295	COG1119	ATPase activity
ALEK_RS08315	COG2207	Transcriptional regulator
ALEK_RS08315	COG1609	Transcriptional regulator
ALEK_RS08320	COG1881	PFAM PEBP family protein
ALEK_RS08350	COG1794	racemase activity, acting on amino acids and derivatives
ALEK_RS08355	COG0583	DNA-binding transcription factor activity
ALEK_RS08360	COG2855	membrane
ALEK_RS08375	COG1733	regulation of RNA biosynthetic process
ALEK_RS08380	COG2249	NAD(P)H dehydrogenase (quinone) activity
ALEK_RS08390	COG0778	Nitroreductase
ALEK_RS08400	COG2197	response regulator
ALEK_RS08410	COG2201	protein-glutamate methylesterase activity
ALEK_RS08415	COG0840	transmembrane signaling receptor activity
ALEK_RS08420	COG3842	ATPase activity
ALEK_RS08475	COG5002	protein histidine kinase activity
ALEK_RS08485	COG0010	Belongs to the arginase family
ALEK_RS08495	COG0301	tRNA thio-modification
ALEK_RS08495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ALEK_RS08510	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ALEK_RS08520	COG0488	(ABC) transporter
ALEK_RS08525	COG1607	acyl-coa hydrolase
ALEK_RS08535	COG5002	protein histidine kinase activity
ALEK_RS08535	COG2205	protein histidine kinase activity
ALEK_RS08535	COG0784	Response regulator, receiver
ALEK_RS08540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ALEK_RS08590	COG2195	Cleaves the N-terminal amino acid of tripeptides
ALEK_RS08595	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ALEK_RS08635	COG0745	RESPONSE REGULATOR receiver
ALEK_RS08640	COG2205	protein histidine kinase activity
ALEK_RS08640	COG4191	Histidine kinase
ALEK_RS08640	COG0745	RESPONSE REGULATOR receiver
ALEK_RS08655	COG4221	oxidoreductase activity
ALEK_RS08660	COG1333	cytochrome c biogenesis protein
ALEK_RS08660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ALEK_RS08665	COG0500	methyltransferase
ALEK_RS08670	COG4251	negative regulation of phosphorylation
ALEK_RS08670	COG3706	GGDEF domain
ALEK_RS08670	COG2203	Gaf domain
ALEK_RS08670	COG5001	Diguanylate cyclase
ALEK_RS08675	COG3706	GGDEF domain
ALEK_RS08680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ALEK_RS08690	COG2188	Transcriptional regulator
ALEK_RS08695	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ALEK_RS08705	COG3639	organic phosphonate transmembrane transporter activity
ALEK_RS08725	COG3627	carbon phosphorus lyase activity
ALEK_RS08730	COG4107	phosphonate C-P lyase system protein PhnK
ALEK_RS08735	COG4778	phosphonate C-P lyase system protein PhnL
ALEK_RS08740	COG3454	Phosphonate metabolism
ALEK_RS08755	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ALEK_RS08755	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ALEK_RS08775	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ALEK_RS08790	COG3040	lipid binding
ALEK_RS08805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ALEK_RS08820	COG3040	lipid binding
ALEK_RS08825	COG2211	Major facilitator Superfamily
ALEK_RS08835	COG0300	oxidoreductase activity
ALEK_RS08855	COG2274	protein secretion by the type I secretion system
ALEK_RS08875	COG0133	tryptophan synthase activity
ALEK_RS08880	COG4191	Histidine kinase
ALEK_RS08885	COG0484	heat shock protein binding
ALEK_RS08890	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ALEK_RS08895	COG0840	transmembrane signaling receptor activity
ALEK_RS08900	COG0840	transmembrane signaling receptor activity
ALEK_RS08910	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ALEK_RS08925	COG0189	ligase activity
ALEK_RS08935	COG0137	argininosuccinate synthase activity
ALEK_RS08945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ALEK_RS08950	COG0802	atpase or kinase
ALEK_RS08955	COG1137	ATPase activity
ALEK_RS08960	COG3706	GGDEF domain
ALEK_RS08965	COG2199	diguanylate cyclase activity
ALEK_RS08965	COG3287	FIST C domain
ALEK_RS08965	COG2200	EAL domain
ALEK_RS08970	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ALEK_RS08975	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ALEK_RS08975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ALEK_RS08995	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ALEK_RS09000	COG2181	nitrate reductase activity
ALEK_RS09000	COG0247	lactate metabolic process
ALEK_RS09005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ALEK_RS09010	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ALEK_RS09015	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ALEK_RS09015	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ALEK_RS09030	COG0745	RESPONSE REGULATOR receiver
ALEK_RS09035	COG0840	transmembrane signaling receptor activity
ALEK_RS09040	COG0113	porphobilinogen synthase activity
ALEK_RS09045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ALEK_RS09050	COG0357	Ribosomal RNA small subunit methyltransferase G
ALEK_RS09125	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ALEK_RS09130	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ALEK_RS09155	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ALEK_RS09155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ALEK_RS09165	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ALEK_RS09175	COG2356	endonuclease I
ALEK_RS09195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ALEK_RS09200	COG0612	Peptidase, M16
ALEK_RS09205	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ALEK_RS09210	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ALEK_RS09220	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ALEK_RS09235	COG0527	aspartate kinase activity
ALEK_RS09240	COG0494	nUDIX hydrolase
ALEK_RS09245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ALEK_RS09250	COG2890	protein-(glutamine-N5) methyltransferase activity
ALEK_RS09255	COG0339	signal peptide processing
ALEK_RS09270	COG0582	viral genome integration into host DNA
ALEK_RS09275	COG2201	protein-glutamate methylesterase activity
ALEK_RS09285	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ALEK_RS09290	COG0643	Histidine kinase
ALEK_RS09290	COG2198	Histidine kinase
ALEK_RS09300	COG1185	polyribonucleotide nucleotidyltransferase activity
ALEK_RS09310	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ALEK_RS09330	COG0659	secondary active sulfate transmembrane transporter activity
ALEK_RS09335	COG1160	GTP binding
ALEK_RS09345	COG1674	ftsk spoiiie
ALEK_RS09345	COG1196	nuclear chromosome segregation
ALEK_RS09350	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALEK_RS09355	COG0440	acetolactate synthase activity
ALEK_RS09360	COG0028	Belongs to the TPP enzyme family
ALEK_RS09375	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ALEK_RS09380	COG4251	negative regulation of phosphorylation
ALEK_RS09380	COG5001	Diguanylate cyclase
ALEK_RS09380	COG2203	Gaf domain
ALEK_RS09380	COG3706	GGDEF domain
ALEK_RS09385	COG0659	secondary active sulfate transmembrane transporter activity
ALEK_RS09410	COG0037	tRNA processing
ALEK_RS09425	COG0303	'Molybdopterin
ALEK_RS09430	COG2203	Gaf domain
ALEK_RS09430	COG3706	GGDEF domain
ALEK_RS09430	COG5001	Diguanylate cyclase
ALEK_RS09430	COG4251	negative regulation of phosphorylation
ALEK_RS09440	COG1322	Protein conserved in bacteria
ALEK_RS09445	COG0501	Belongs to the peptidase M48B family
ALEK_RS09450	COG3706	GGDEF domain
ALEK_RS09460	COG0824	Thioesterase
ALEK_RS09500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ALEK_RS09505	COG4172	Belongs to the ABC transporter superfamily
ALEK_RS09510	COG0534	Mate efflux family protein
ALEK_RS09520	COG0840	transmembrane signaling receptor activity
ALEK_RS09525	COG0840	transmembrane signaling receptor activity
ALEK_RS09530	COG0667	Aldo Keto reductase
ALEK_RS09560	COG1797	cobyrinic acid a,c-diamide synthase activity
ALEK_RS09620	COG2226	methyltransferase
ALEK_RS09645	COG2207	Transcriptional regulator
ALEK_RS09650	COG2226	methyltransferase
ALEK_RS09660	COG1122	ATPase activity
ALEK_RS09685	COG0546	phosphoglycolate phosphatase activity
ALEK_RS09695	COG0330	HflC and HflK could
ALEK_RS09705	COG0745	RESPONSE REGULATOR receiver
ALEK_RS09715	COG0788	formyltetrahydrofolate deformylase activity
ALEK_RS09720	COG0469	pyruvate kinase activity
ALEK_RS09725	COG1012	belongs to the aldehyde dehydrogenase family
ALEK_RS09730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ALEK_RS09745	COG0395	ABC-type sugar transport system, permease component
ALEK_RS09765	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ALEK_RS09770	COG2188	Transcriptional regulator
ALEK_RS09775	COG2188	Transcriptional regulator
ALEK_RS09780	COG0280	phosphate acetyltransferase
ALEK_RS09780	COG0281	malic enzyme
ALEK_RS09785	COG1027	Aspartate ammonia-lyase
ALEK_RS09790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ALEK_RS09795	COG3852	Histidine kinase
ALEK_RS09800	COG0745	RESPONSE REGULATOR receiver
ALEK_RS09820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ALEK_RS09840	COG3681	Belongs to the UPF0597 family
ALEK_RS09845	COG0583	DNA-binding transcription factor activity
ALEK_RS09855	COG2239	Acts as a magnesium transporter
ALEK_RS09870	COG0754	glutathionylspermidine amidase activity
ALEK_RS09905	COG0672	)-iron permease
ALEK_RS09910	COG0010	Belongs to the arginase family
ALEK_RS09915	COG1228	amidohydrolase
ALEK_RS09920	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ALEK_RS09925	COG2986	histidine ammonia-lyase
ALEK_RS09930	COG2188	Transcriptional regulator
ALEK_RS09965	COG1663	tetraacyldisaccharide 4'-kinase activity
ALEK_RS09975	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ALEK_RS10000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ALEK_RS10005	COG0805	protein transport
ALEK_RS10010	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ALEK_RS10040	COG0733	neurotransmitter:sodium symporter activity
ALEK_RS10060	COG1929	Belongs to the glycerate kinase type-1 family
ALEK_RS10065	COG3011	Protein conserved in bacteria
ALEK_RS10080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ALEK_RS10100	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ALEK_RS10115	COG0745	RESPONSE REGULATOR receiver
ALEK_RS10125	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ALEK_RS10170	COG3813	Protein conserved in bacteria
ALEK_RS10180	COG4991	sh3 domain protein
ALEK_RS10195	COG0745	RESPONSE REGULATOR receiver
ALEK_RS10200	COG3850	Histidine kinase
ALEK_RS10200	COG5002	protein histidine kinase activity
ALEK_RS10205	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ALEK_RS10210	COG4269	membrane
ALEK_RS10215	COG0501	Belongs to the peptidase M48B family
ALEK_RS10220	COG0419	ATPase involved in DNA repair
ALEK_RS10230	COG2199	diguanylate cyclase activity
ALEK_RS10230	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ALEK_RS10240	COG2205	protein histidine kinase activity
ALEK_RS10245	COG0840	transmembrane signaling receptor activity
ALEK_RS10275	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ALEK_RS10290	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ALEK_RS10295	COG1073	alpha beta
ALEK_RS10310	COG2203	Gaf domain
ALEK_RS10310	COG2199	diguanylate cyclase activity
ALEK_RS10320	COG4865	methylaspartate mutase activity
ALEK_RS10330	COG0318	PFAM AMP-dependent synthetase and ligase
ALEK_RS10360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ALEK_RS10380	COG0275	rRNA processing
ALEK_RS10390	COG0776	regulation of translation
ALEK_RS10405	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ALEK_RS10415	COG3279	Response regulator of the LytR AlgR family
ALEK_RS10420	COG3275	phosphorelay sensor kinase activity
ALEK_RS10425	COG1233	COG1233 Phytoene dehydrogenase and related
ALEK_RS10435	COG3272	Protein of unknown function (DUF1722)
ALEK_RS10440	COG1643	Atp-dependent helicase
ALEK_RS10450	COG1283	sodium-dependent phosphate transmembrane transporter activity
ALEK_RS10455	COG0513	Belongs to the DEAD box helicase family
ALEK_RS10470	COG4977	sequence-specific DNA binding
ALEK_RS10470	COG1917	Cupin 2, conserved barrel domain protein
ALEK_RS10480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ALEK_RS10480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ALEK_RS10495	COG0642	Histidine kinase
ALEK_RS10500	COG0745	RESPONSE REGULATOR receiver
ALEK_RS10530	COG1132	(ABC) transporter
ALEK_RS10540	COG0628	permease
ALEK_RS10555	COG1280	lysine exporter protein (LysE YggA)
ALEK_RS10565	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ALEK_RS10570	COG0653	protein targeting
ALEK_RS10575	COG4591	ABC-type transport system involved in lipoprotein release permease component
ALEK_RS10580	COG4191	Histidine kinase
ALEK_RS10580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALEK_RS10590	COG0784	Response regulator, receiver
ALEK_RS10590	COG3437	response regulator, receiver
ALEK_RS10610	COG0039	L-malate dehydrogenase activity
ALEK_RS10620	COG1230	cation diffusion facilitator family transporter
ALEK_RS10635	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ALEK_RS10635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ALEK_RS10645	COG0484	heat shock protein binding
ALEK_RS10650	COG0789	Transcriptional regulator
ALEK_RS10655	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ALEK_RS10660	COG0849	cell division
ALEK_RS10670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ALEK_RS10695	COG4783	chaperone-mediated protein folding
ALEK_RS10715	COG0768	penicillin binding
ALEK_RS10725	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ALEK_RS10730	COG1338	Plays a role in the flagellum-specific transport system
ALEK_RS10735	COG1047	Peptidyl-prolyl cis-trans
ALEK_RS10765	COG2205	protein histidine kinase activity
ALEK_RS10770	COG0747	negative chemotaxis
ALEK_RS10775	COG0601	transmembrane transport
ALEK_RS10780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ALEK_RS10785	COG0444	Belongs to the ABC transporter superfamily
ALEK_RS10790	COG4608	Belongs to the ABC transporter superfamily
ALEK_RS10815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ALEK_RS10830	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ALEK_RS10835	COG0131	Imidazoleglycerol-phosphate dehydratase
ALEK_RS10840	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ALEK_RS10845	COG0084	hydrolase, TatD family'
ALEK_RS10855	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ALEK_RS10860	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ALEK_RS10865	COG0359	binds to the 23S rRNA
ALEK_RS10870	COG0642	Histidine kinase
ALEK_RS10875	COG0745	RESPONSE REGULATOR receiver
ALEK_RS10890	COG0163	prenyltransferase activity
ALEK_RS10895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ALEK_RS10900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ALEK_RS10905	COG0124	histidyl-tRNA synthetase
ALEK_RS10910	COG1166	arginine decarboxylase activity
ALEK_RS10915	COG1045	serine acetyltransferase
ALEK_RS10930	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ALEK_RS10950	COG0753	catalase activity
ALEK_RS10955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ALEK_RS10975	COG4536	flavin adenine dinucleotide binding
ALEK_RS10980	COG3338	carbonate dehydratase activity
ALEK_RS10985	COG0748	coenzyme F420 binding
ALEK_RS11000	COG0628	permease
ALEK_RS11030	COG2199	diguanylate cyclase activity
ALEK_RS11030	COG2200	EAL domain
ALEK_RS11030	COG3287	FIST C domain
ALEK_RS11035	COG1028	Short-chain dehydrogenase reductase Sdr
ALEK_RS11040	COG2346	COG2346, Truncated hemoglobins
ALEK_RS11050	COG2223	nitrite transmembrane transporter activity
ALEK_RS11055	COG0205	6-phosphofructokinase activity
ALEK_RS11060	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ALEK_RS11070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ALEK_RS11075	COG2203	Gaf domain
ALEK_RS11075	COG2199	diguanylate cyclase activity
ALEK_RS11085	COG4565	transcriptional regulatory protein
ALEK_RS11095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ALEK_RS11105	COG2207	Transcriptional regulator
ALEK_RS11105	COG1917	Cupin 2, conserved barrel domain protein
ALEK_RS11110	COG3708	Transcriptional regulator
ALEK_RS11110	COG2207	Transcriptional regulator
ALEK_RS11130	COG1489	DNA binding
ALEK_RS11145	COG2207	Transcriptional regulator
ALEK_RS11145	COG1917	Cupin 2, conserved barrel domain protein
ALEK_RS11155	COG1253	flavin adenine dinucleotide binding
ALEK_RS11175	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ALEK_RS11200	COG0251	oxidation-reduction process
ALEK_RS11205	COG2860	membrane
ALEK_RS11215	COG4999	Histidine kinase
ALEK_RS11215	COG3850	Histidine kinase
ALEK_RS11215	COG3437	response regulator, receiver
ALEK_RS11215	COG2205	protein histidine kinase activity
ALEK_RS11220	COG1231	oxidoreductase activity
ALEK_RS11225	COG3852	Histidine kinase
ALEK_RS11250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ALEK_RS11260	COG2010	Cytochrome c
ALEK_RS11265	COG3256	nitric oxide reductase
ALEK_RS11280	COG0716	FMN binding
ALEK_RS11290	COG2133	pyrroloquinoline quinone binding
ALEK_RS11300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ALEK_RS11330	COG0596	Alpha beta hydrolase
ALEK_RS11340	COG2207	Transcriptional regulator
ALEK_RS11345	COG2249	NAD(P)H dehydrogenase (quinone) activity
ALEK_RS11355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ALEK_RS11360	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ALEK_RS11365	COG1794	racemase activity, acting on amino acids and derivatives
ALEK_RS11425	COG2831	hemolysin activation secretion protein
ALEK_RS11430	COG0745	RESPONSE REGULATOR receiver
ALEK_RS11435	COG3852	Histidine kinase
ALEK_RS11440	COG4753	response regulator
ALEK_RS11440	COG2207	Transcriptional regulator
ALEK_RS11490	COG1773	rubredoxin
ALEK_RS11510	COG1187	pseudouridine synthase activity
ALEK_RS11550	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ALEK_RS11570	COG0251	oxidation-reduction process
ALEK_RS11590	COG0519	Catalyzes the synthesis of GMP from XMP
ALEK_RS11590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ALEK_RS11600	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ALEK_RS11605	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ALEK_RS11615	COG1451	nucleotide metabolic process
ALEK_RS11625	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ALEK_RS11640	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ALEK_RS11670	COG0745	RESPONSE REGULATOR receiver
ALEK_RS11675	COG0745	RESPONSE REGULATOR receiver
ALEK_RS11680	COG2202	Pas domain
ALEK_RS11680	COG2205	protein histidine kinase activity
ALEK_RS11695	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ALEK_RS11725	COG0438	transferase activity, transferring glycosyl groups
ALEK_RS11735	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ALEK_RS11740	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ALEK_RS11740	COG0662	Cupin 2, conserved barrel domain protein
ALEK_RS11785	COG1045	serine acetyltransferase
ALEK_RS11820	COG1610	YqeY-like protein
ALEK_RS11825	COG3706	GGDEF domain
ALEK_RS11840	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ALEK_RS11880	COG1902	pentaerythritol trinitrate reductase activity
ALEK_RS11890	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ALEK_RS11900	COG0840	transmembrane signaling receptor activity
ALEK_RS11915	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ALEK_RS11925	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ALEK_RS11945	COG5000	phosphorelay sensor kinase activity
ALEK_RS11975	COG0745	RESPONSE REGULATOR receiver
ALEK_RS11980	COG0642	Histidine kinase
ALEK_RS11990	COG0488	(ABC) transporter
ALEK_RS12005	COG2226	methyltransferase
ALEK_RS12015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ALEK_RS12025	COG0784	Response regulator, receiver
ALEK_RS12025	COG4191	Histidine kinase
ALEK_RS12035	COG2207	Transcriptional regulator
ALEK_RS12080	COG0300	oxidoreductase activity
ALEK_RS12085	COG1757	Na H antiporter
ALEK_RS12100	COG2207	Transcriptional regulator
ALEK_RS12100	COG4753	response regulator
ALEK_RS12115	COG1566	PFAM secretion protein HlyD family protein
ALEK_RS12130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ALEK_RS12135	COG0742	ribosomal rna small subunit methyltransferase
ALEK_RS12145	COG1418	mRNA catabolic process
ALEK_RS12155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ALEK_RS12160	COG0552	protein localization to endoplasmic reticulum
ALEK_RS12165	COG1280	lysine exporter protein (LysE YggA)
ALEK_RS12175	COG0745	RESPONSE REGULATOR receiver
ALEK_RS12180	COG0642	Histidine kinase
ALEK_RS12185	COG3258	Cytochrome c
ALEK_RS12190	COG3150	esterase
ALEK_RS12200	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ALEK_RS12210	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ALEK_RS12225	COG1592	Rubrerythrin
ALEK_RS12230	COG1592	Rubrerythrin
ALEK_RS12240	COG0728	peptidoglycan biosynthetic process
ALEK_RS12250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ALEK_RS12255	COG1845	cytochrome c oxidase, subunit III
ALEK_RS12270	COG0109	protoheme IX farnesyltransferase activity
ALEK_RS12275	COG1132	(ABC) transporter
ALEK_RS12280	COG0167	dihydroorotate dehydrogenase activity
ALEK_RS12295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ALEK_RS12300	COG1028	Short-chain dehydrogenase reductase Sdr
ALEK_RS12305	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ALEK_RS12310	COG0750	zinc metalloprotease
ALEK_RS12315	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ALEK_RS12320	COG1942	4-Oxalocrotonate Tautomerase
ALEK_RS12335	COG0583	DNA-binding transcription factor activity
ALEK_RS12340	COG4191	Histidine kinase
ALEK_RS12345	COG0134	indole-3-glycerol-phosphate synthase activity
ALEK_RS12355	COG0727	PFAM Uncharacterised protein family (UPF0153)
ALEK_RS12360	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ALEK_RS12370	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ALEK_RS12370	COG0674	pyruvate-flavodoxin oxidoreductase activity
ALEK_RS12375	COG1013	pyruvate-flavodoxin oxidoreductase activity
ALEK_RS12385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ALEK_RS12390	COG2176	DNA-directed DNA polymerase activity
ALEK_RS12395	COG0135	phosphoribosylanthranilate isomerase activity
ALEK_RS12400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ALEK_RS12405	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ALEK_RS12415	COG0494	nUDIX hydrolase
ALEK_RS12420	COG0642	Histidine kinase
ALEK_RS12425	COG0745	RESPONSE REGULATOR receiver
ALEK_RS12435	COG1666	GTP binding
ALEK_RS12440	COG2233	PERMEase
ALEK_RS12445	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ALEK_RS12460	COG2363	Small membrane protein
ALEK_RS12470	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ALEK_RS12475	COG2252	PERMEase
ALEK_RS12490	COG2151	metal-sulfur cluster biosynthetic enzyme
ALEK_RS12495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ALEK_RS12500	COG4753	response regulator
ALEK_RS12500	COG2207	Transcriptional regulator
ALEK_RS12565	COG0731	radical SAM domain protein
ALEK_RS12570	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ALEK_RS12580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ALEK_RS12595	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ALEK_RS12600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ALEK_RS12605	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ALEK_RS12620	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ALEK_RS12630	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ALEK_RS12630	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ALEK_RS12635	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ALEK_RS12640	COG0859	PFAM glycosyl transferase family 9
ALEK_RS12645	COG0438	transferase activity, transferring glycosyl groups
ALEK_RS12655	COG0859	PFAM glycosyl transferase family 9
ALEK_RS12665	COG0438	transferase activity, transferring glycosyl groups
ALEK_RS12690	COG1088	dTDP-glucose 4,6-dehydratase activity
ALEK_RS12695	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ALEK_RS12715	COG0859	PFAM glycosyl transferase family 9
ALEK_RS12725	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ALEK_RS12735	COG0493	'glutamate synthase
ALEK_RS12740	COG0067	glutamate synthase
ALEK_RS12740	COG0069	glutamate synthase activity
ALEK_RS12740	COG0070	glutamate synthase
ALEK_RS12780	COG1136	(ABC) transporter
ALEK_RS12810	COG3278	Belongs to the heme-copper respiratory oxidase family
ALEK_RS12910	COG2197	response regulator
ALEK_RS12970	COG2204	response regulator
ALEK_RS13065	COG0284	orotidine-5'-phosphate decarboxylase activity
ALEK_RS13070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ALEK_RS13075	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ALEK_RS13080	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ALEK_RS13095	COG0069	glutamate synthase activity
ALEK_RS13105	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ALEK_RS13135	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ALEK_RS13140	COG1450	Type ii and iii secretion system protein
ALEK_RS13185	COG1739	Uncharacterized protein family UPF0029
ALEK_RS13200	COG2226	methyltransferase
ALEK_RS13205	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ALEK_RS13215	COG0277	FAD linked oxidase domain protein
ALEK_RS13255	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ALEK_RS13260	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ALEK_RS13265	COG1047	Peptidyl-prolyl cis-trans
ALEK_RS13280	COG0823	Involved in the tonB-independent uptake of proteins
ALEK_RS13290	COG0848	biopolymer transport protein
ALEK_RS13295	COG0811	peptide transport
ALEK_RS13300	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ALEK_RS13305	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ALEK_RS13310	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ALEK_RS13315	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ALEK_RS13320	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ALEK_RS13325	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ALEK_RS13335	COG1475	DNA binding
ALEK_RS13340	COG1192	Involved in chromosome partitioning
ALEK_RS13355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ALEK_RS13360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ALEK_RS13365	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ALEK_RS13370	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ALEK_RS13375	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ALEK_RS13380	COG0251	oxidation-reduction process
ALEK_RS13385	COG0358	DNA primase activity
ALEK_RS13395	COG0571	ribonuclease III activity
ALEK_RS13400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ALEK_RS13405	COG0501	Belongs to the peptidase M48B family
ALEK_RS13410	COG0588	phosphoglycerate mutase activity
ALEK_RS13425	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ALEK_RS13435	COG0706	membrane insertase activity
ALEK_RS13440	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ALEK_RS13450	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ALEK_RS13460	COG0542	response to heat
ALEK_RS13480	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ALEK_RS13495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ALEK_RS13500	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ALEK_RS13505	COG3437	response regulator, receiver
ALEK_RS13510	COG3437	response regulator, receiver
ALEK_RS13520	COG0069	glutamate synthase activity
ALEK_RS13525	COG2259	Doxx family
ALEK_RS13530	COG0179	Fumarylacetoacetate (FAA) hydrolase
ALEK_RS13540	COG2259	Doxx family
ALEK_RS13585	COG0138	bifunctional purine biosynthesis protein purh
ALEK_RS13600	COG4263	nitrous-oxide reductase activity
ALEK_RS13615	COG0437	4 iron, 4 sulfur cluster binding
ALEK_RS13630	COG0348	domain, Protein
ALEK_RS13635	COG1131	(ABC) transporter
ALEK_RS13645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ALEK_RS13650	COG0739	heme binding
ALEK_RS13655	COG2239	Acts as a magnesium transporter
ALEK_RS13675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ALEK_RS13690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ALEK_RS13695	COG0606	chelatase, subunit chli
ALEK_RS13705	COG0840	transmembrane signaling receptor activity
ALEK_RS13715	COG0242	peptide deformylase activity
ALEK_RS13720	COG0740	serine-type endopeptidase activity
ALEK_RS13725	COG0544	peptidyl-prolyl cis-trans isomerase activity
ALEK_RS13730	COG2304	oxidoreductase activity
ALEK_RS13735	COG2326	polyphosphate kinase activity
ALEK_RS13750	COG1773	rubredoxin
ALEK_RS13840	COG0840	transmembrane signaling receptor activity
ALEK_RS13845	COG0745	RESPONSE REGULATOR receiver
ALEK_RS13880	COG0716	FMN binding
ALEK_RS13930	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ALEK_RS13965	COG0159	tryptophan synthase activity
ALEK_RS13975	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ALEK_RS13980	COG2255	four-way junction helicase activity
ALEK_RS13985	COG0628	permease
ALEK_RS14000	COG4628	conserved protein (DUF2132)
ALEK_RS14015	COG0745	RESPONSE REGULATOR receiver
ALEK_RS14020	COG0642	Histidine kinase
ALEK_RS14030	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ALEK_RS14045	COG0542	response to heat
ALEK_RS14050	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ALEK_RS14055	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ALEK_RS14065	COG0318	PFAM AMP-dependent synthetase and ligase
ALEK_RS14070	COG2030	dehydratase
ALEK_RS14110	COG0840	transmembrane signaling receptor activity
ALEK_RS14120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ALEK_RS14155	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ALEK_RS14160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ALEK_RS14165	COG1157	protein secretion by the type III secretion system
ALEK_RS14175	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ALEK_RS14195	COG1677	Flagellar hook-basal body complex protein FliE
ALEK_RS14205	COG0455	bacterial-type flagellum organization
ALEK_RS14210	COG1419	protein localization to endoplasmic reticulum
ALEK_RS14225	COG3951	Flagellar rod assembly protein muramidase FlgJ
ALEK_RS14235	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ALEK_RS14240	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ALEK_RS14260	COG1749	Flagellar hook protein flgE
ALEK_RS14285	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ALEK_RS14290	COG1766	The M ring may be actively involved in energy transduction
ALEK_RS14295	COG1815	bacterial-type flagellum-dependent cell motility
ALEK_RS14300	COG4786	Flagellar basal body rod
ALEK_RS14310	COG0745	RESPONSE REGULATOR receiver
ALEK_RS14330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ALEK_RS14340	COG0228	four-way junction DNA binding
ALEK_RS14345	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ALEK_RS14355	COG1519	Transferase
ALEK_RS14355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ALEK_RS14365	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ALEK_RS14370	COG0752	glycyl-tRNA synthetase alpha subunit
ALEK_RS14375	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ALEK_RS14455	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ALEK_RS14460	COG0497	DNA recombination
ALEK_RS14465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ALEK_RS14470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ALEK_RS14475	COG0049	tRNA binding
ALEK_RS14480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ALEK_RS14490	COG0583	DNA-binding transcription factor activity
ALEK_RS14495	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ALEK_RS14500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ALEK_RS14515	COG2267	carboxylic ester hydrolase activity
ALEK_RS14520	COG0251	oxidation-reduction process
ALEK_RS14525	COG2855	membrane
ALEK_RS14530	COG1671	Belongs to the UPF0178 family
ALEK_RS14540	COG4895	conserved protein (DUF2196)
ALEK_RS14550	COG0038	chloride channel
ALEK_RS14560	COG0840	transmembrane signaling receptor activity
ALEK_RS14575	COG2202	Pas domain
ALEK_RS14575	COG2200	EAL domain
ALEK_RS14575	COG2199	diguanylate cyclase activity
ALEK_RS14585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ALEK_RS14590	COG0085	RNA polymerase activity
ALEK_RS14595	COG0222	ribosome binding
ALEK_RS14600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ALEK_RS14605	COG0081	regulation of translation
ALEK_RS14610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ALEK_RS14615	COG0250	Participates in transcription elongation, termination and antitermination
ALEK_RS14630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ALEK_RS14635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ALEK_RS14665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ALEK_RS14670	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ALEK_RS14680	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ALEK_RS14685	COG0174	glutamine synthetase
ALEK_RS14695	COG0314	molybdopterin synthase activity
ALEK_RS14705	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ALEK_RS14710	COG1968	undecaprenyl-diphosphatase activity
ALEK_RS14720	COG0772	Belongs to the SEDS family
ALEK_RS14730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ALEK_RS14775	COG0512	Glutamine amidotransferase of anthranilate synthase
ALEK_RS14785	COG1840	ABC-type Fe3 transport system, periplasmic component
ALEK_RS14795	COG3842	ATPase activity
ALEK_RS14800	COG3706	GGDEF domain
ALEK_RS14805	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ALEK_RS14810	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ALEK_RS14815	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALEK_RS14820	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALEK_RS14825	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALEK_RS14825	COG0649	NAD binding
ALEK_RS14830	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ALEK_RS14840	COG0372	Belongs to the citrate synthase family
ALEK_RS14845	COG1034	ATP synthesis coupled electron transport
ALEK_RS14850	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ALEK_RS14855	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALEK_RS14860	COG0839	Belongs to the complex I subunit 6 family
ALEK_RS14865	COG0713	ATP synthesis coupled electron transport
ALEK_RS14870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ALEK_RS14880	COG1007	ATP synthesis coupled electron transport
ALEK_RS14890	COG1053	succinate dehydrogenase
ALEK_RS14895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ALEK_RS14910	COG0519	Catalyzes the synthesis of GMP from XMP
ALEK_RS14915	COG1451	nucleotide metabolic process
ALEK_RS14940	COG2183	response to ionizing radiation
ALEK_RS14960	COG0251	oxidation-reduction process
ALEK_RS14975	COG2095	MarC family integral membrane protein
ALEK_RS14980	COG0765	amino acid transport
ALEK_RS15010	COG0500	methyltransferase
ALEK_RS15015	COG0640	Transcriptional regulator
ALEK_RS15025	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ALEK_RS15030	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ALEK_RS15060	COG0514	ATP-dependent DNA helicase (RecQ)
ALEK_RS15070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ALEK_RS15095	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ALEK_RS15100	COG0372	Belongs to the citrate synthase family
ALEK_RS15105	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ALEK_RS15110	COG2828	Protein conserved in bacteria
ALEK_RS15115	COG2203	Gaf domain
ALEK_RS15115	COG2199	diguanylate cyclase activity
ALEK_RS15125	COG1879	ABC-type sugar transport system periplasmic component
ALEK_RS15135	COG0181	hydroxymethylbilane synthase activity
ALEK_RS15150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ALEK_RS15155	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ALEK_RS15175	COG2011	ABC-type metal ion transport system permease component
ALEK_RS15180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ALEK_RS15185	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ALEK_RS15190	COG0450	alkyl hydroperoxide reductase
ALEK_RS15200	COG0105	UTP biosynthetic process
ALEK_RS15210	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ALEK_RS15215	COG0416	fatty acid biosynthetic process
ALEK_RS15220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ALEK_RS15230	COG0745	RESPONSE REGULATOR receiver
ALEK_RS15235	COG2353	YceI-like domain
ALEK_RS15250	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ALEK_RS15280	COG2201	protein-glutamate methylesterase activity
ALEK_RS15290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ALEK_RS15295	COG0540	Belongs to the ATCase OTCase family
ALEK_RS15305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ALEK_RS15315	COG3852	Histidine kinase
ALEK_RS15320	COG0469	pyruvate kinase activity
ALEK_RS15335	COG0642	Histidine kinase
ALEK_RS15350	COG0792	nuclease activity
ALEK_RS15355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ALEK_RS15355	COG0475	glutathione-regulated potassium exporter activity
ALEK_RS15365	COG1917	Cupin 2, conserved barrel domain protein
ALEK_RS15365	COG2207	Transcriptional regulator
ALEK_RS15370	COG0156	8-amino-7-oxononanoate synthase activity
ALEK_RS15380	COG0288	reversible hydration of carbon dioxide
ALEK_RS15390	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ALEK_RS15400	COG2121	Domain of unknown function (DUF374)
ALEK_RS15405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ALEK_RS15415	COG0195	Participates in both transcription termination and antitermination
ALEK_RS15420	COG0215	cysteine-tRNA ligase activity
ALEK_RS15435	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ALEK_RS15440	COG0629	single-stranded DNA binding
ALEK_RS15445	COG0360	Binds together with S18 to 16S ribosomal RNA
ALEK_RS15455	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ALEK_RS15470	COG0557	exoribonuclease II activity
ALEK_RS15490	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ALEK_RS15510	COG1917	Cupin 2, conserved barrel domain protein
ALEK_RS15510	COG2207	Transcriptional regulator
ALEK_RS15515	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ALEK_RS15530	COG0436	Aminotransferase
ALEK_RS15550	COG3706	GGDEF domain
ALEK_RS15555	COG0343	queuine tRNA-ribosyltransferase activity
ALEK_RS15560	COG1450	Type ii and iii secretion system protein
ALEK_RS15585	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ALEK_RS15610	COG3706	GGDEF domain
ALEK_RS15610	COG4251	negative regulation of phosphorylation
ALEK_RS15610	COG5001	Diguanylate cyclase
ALEK_RS15610	COG2203	Gaf domain
ALEK_RS15620	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ALEK_RS15630	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ALEK_RS15640	COG0560	Phosphoserine phosphatase
ALEK_RS15645	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ALEK_RS15655	COG3437	response regulator, receiver
ALEK_RS15655	COG0784	Response regulator, receiver
ALEK_RS15660	COG0736	holo-[acyl-carrier-protein] synthase activity
ALEK_RS15665	COG0601	transmembrane transport
ALEK_RS15670	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ALEK_RS15680	COG2353	YceI-like domain
ALEK_RS15685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ALEK_RS15705	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ALEK_RS15750	COG1706	bacterial-type flagellum-dependent cell motility
ALEK_RS15755	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ALEK_RS15760	COG0418	dihydroorotase activity
ALEK_RS15770	COG0004	ammonium transporteR
ALEK_RS15780	COG0004	ammonium transporteR
ALEK_RS15785	COG0840	transmembrane signaling receptor activity
ALEK_RS15790	COG2200	EAL domain
ALEK_RS15795	COG1116	anion transmembrane transporter activity
ALEK_RS15805	COG1116	anion transmembrane transporter activity
ALEK_RS15805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ALEK_RS15810	COG2223	nitrite transmembrane transporter activity
ALEK_RS15815	COG0515	serine threonine protein kinase
ALEK_RS15815	COG2815	serine threonine protein kinase
ALEK_RS15820	COG0243	molybdopterin cofactor binding
ALEK_RS15830	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ALEK_RS15835	COG0243	molybdopterin cofactor binding
ALEK_RS15855	COG1346	cytolysis
ALEK_RS15865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ALEK_RS15895	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ALEK_RS15900	COG0204	Acyl-transferase
ALEK_RS15900	COG0318	PFAM AMP-dependent synthetase and ligase
ALEK_RS15910	COG2962	Rard protein
ALEK_RS15915	COG4191	Histidine kinase
ALEK_RS15915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ALEK_RS15930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ALEK_RS15945	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ALEK_RS15955	COG0640	Transcriptional regulator
ALEK_RS15960	COG2258	MOSC domain
ALEK_RS15965	COG1346	cytolysis
ALEK_RS15985	COG2084	Dehydrogenase
ALEK_RS16000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ALEK_RS16005	COG4191	Histidine kinase
ALEK_RS16035	COG0745	RESPONSE REGULATOR receiver
ALEK_RS16070	COG0129	dihydroxy-acid dehydratase activity
ALEK_RS16075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ALEK_RS16080	COG0745	RESPONSE REGULATOR receiver
ALEK_RS16085	COG0642	Histidine kinase
ALEK_RS16095	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ALEK_RS16100	COG1492	cobalamin metabolic process
ALEK_RS16105	COG3437	response regulator, receiver
ALEK_RS16105	COG0784	Response regulator, receiver
ALEK_RS16130	COG2199	diguanylate cyclase activity
ALEK_RS16130	COG2203	Gaf domain
ALEK_RS16155	COG2095	MarC family integral membrane protein
ALEK_RS16160	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ALEK_RS16175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ALEK_RS16185	COG2199	diguanylate cyclase activity
ALEK_RS16185	COG3287	FIST C domain
ALEK_RS16185	COG2200	EAL domain
ALEK_RS16190	COG0688	phosphatidylethanolamine metabolic process
ALEK_RS16200	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ALEK_RS16210	COG0443	Heat shock 70 kDa protein
ALEK_RS16215	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ALEK_RS16225	COG2358	TRAP transporter, solute receptor (TAXI family
ALEK_RS16235	COG0745	RESPONSE REGULATOR receiver
ALEK_RS16245	COG0101	tRNA pseudouridine synthase activity
ALEK_RS16255	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ALEK_RS16260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ALEK_RS16270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ALEK_RS16280	COG0513	Belongs to the DEAD box helicase family
ALEK_RS16285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ALEK_RS16375	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ALEK_RS16405	COG2089	acid synthase
ALEK_RS16415	COG1086	Polysaccharide biosynthesis protein
ALEK_RS16425	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ALEK_RS16430	COG0148	phosphopyruvate hydratase activity
ALEK_RS16445	COG0475	glutathione-regulated potassium exporter activity
ALEK_RS16445	COG0569	domain protein
ALEK_RS16450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ALEK_RS16465	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ALEK_RS16470	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ALEK_RS16480	COG1007	ATP synthesis coupled electron transport
ALEK_RS16490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ALEK_RS16495	COG0713	ATP synthesis coupled electron transport
ALEK_RS16505	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALEK_RS16510	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ALEK_RS16515	COG1034	ATP synthesis coupled electron transport
ALEK_RS16530	COG0649	NAD binding
ALEK_RS16535	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALEK_RS16540	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALEK_RS16545	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALEK_RS16550	COG0840	transmembrane signaling receptor activity
ALEK_RS16595	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ALEK_RS16640	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ALEK_RS16650	COG2199	diguanylate cyclase activity
ALEK_RS16650	COG2200	EAL domain
ALEK_RS16650	COG3287	FIST C domain
ALEK_RS16655	COG0745	RESPONSE REGULATOR receiver
ALEK_RS16670	COG3706	GGDEF domain
ALEK_RS16685	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ALEK_RS16690	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALEK_RS16695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ALEK_RS16700	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALEK_RS16705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ALEK_RS16710	COG1077	Cell shape determining protein MreB Mrl
ALEK_RS16725	COG0840	transmembrane signaling receptor activity
ALEK_RS16730	COG0445	tRNA wobble uridine modification
ALEK_RS16740	COG0348	domain, Protein
ALEK_RS16745	COG0504	CTP synthase activity
ALEK_RS16750	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ALEK_RS16790	COG0587	DNA-directed DNA polymerase activity
ALEK_RS16795	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ALEK_RS16820	COG0315	cyclic pyranopterin monophosphate synthase activity
ALEK_RS16825	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ALEK_RS16865	COG0670	Belongs to the BI1 family
ALEK_RS16870	COG0352	thiamine-phosphate diphosphorylase activity
ALEK_RS16880	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ALEK_RS16890	COG0233	cytoplasmic translational termination
ALEK_RS16895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ALEK_RS16900	COG1714	RDD family
ALEK_RS16905	COG2814	Major facilitator Superfamily
ALEK_RS16910	COG0840	transmembrane signaling receptor activity
ALEK_RS16915	COG3706	GGDEF domain
ALEK_RS16920	COG0745	RESPONSE REGULATOR receiver
ALEK_RS16925	COG3022	response to hydroperoxide
ALEK_RS16960	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ALEK_RS16965	COG1012	belongs to the aldehyde dehydrogenase family
ALEK_RS17030	COG2081	HI0933 family
ALEK_RS17035	COG2258	MOSC domain
ALEK_RS17060	COG1959	2 iron, 2 sulfur cluster binding
ALEK_RS17065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ALEK_RS17080	COG0175	sulfate reduction
ALEK_RS17085	COG2895	sulfate adenylyltransferase (ATP) activity
ALEK_RS17090	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ALEK_RS17100	COG1408	metallophosphoesterase
ALEK_RS17120	COG2066	Belongs to the glutaminase family
ALEK_RS17130	COG4772	TonB-dependent receptor
ALEK_RS17140	COG1595	DNA-templated transcription, initiation
ALEK_RS17145	COG0697	spore germination
ALEK_RS17150	COG2860	membrane
ALEK_RS17155	COG4251	negative regulation of phosphorylation
ALEK_RS17155	COG2203	Gaf domain
ALEK_RS17155	COG5001	Diguanylate cyclase
ALEK_RS17155	COG3706	GGDEF domain
ALEK_RS17165	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ALEK_RS17170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group