locus-tag	class	description
APAC_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APAC_RS00010	COG0592	DNA-directed DNA polymerase activity
APAC_RS00015	COG0187	DNA topoisomerase II activity
APAC_RS00020	COG0492	ferredoxin-NADP+ reductase activity
APAC_RS00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APAC_RS00050	COG3328	transposase activity
APAC_RS00080	COG0582	viral genome integration into host DNA
APAC_RS00090	COG1238	metal cluster binding
APAC_RS00100	COG5002	protein histidine kinase activity
APAC_RS00100	COG5001	Diguanylate cyclase
APAC_RS00105	COG3842	ATPase activity
APAC_RS00135	COG0730	response to heat
APAC_RS00155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APAC_RS00170	COG2801	Transposase and inactivated derivatives
APAC_RS00175	COG2963	transposase activity
APAC_RS00180	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
APAC_RS00185	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
APAC_RS00190	COG0564	pseudouridine synthase activity
APAC_RS00195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APAC_RS00200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APAC_RS00205	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APAC_RS00210	COG0133	tryptophan synthase activity
APAC_RS00230	COG2885	chlorophyll binding
APAC_RS00230	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APAC_RS00240	COG0604	alcohol dehydrogenase
APAC_RS00245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APAC_RS00250	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APAC_RS00275	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
APAC_RS00280	COG0745	RESPONSE REGULATOR receiver
APAC_RS00285	COG4191	Histidine kinase
APAC_RS00290	COG1556	Lactate utilization protein
APAC_RS00295	COG1139	Iron-sulfur cluster binding protein
APAC_RS00300	COG0247	lactate metabolic process
APAC_RS00310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APAC_RS00320	COG0439	Biotin carboxylase
APAC_RS00325	COG0513	Belongs to the DEAD box helicase family
APAC_RS00330	COG0306	phosphate transporter
APAC_RS00340	COG0367	asparagine synthase
APAC_RS00350	COG0778	Nitroreductase
APAC_RS00355	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
APAC_RS00365	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
APAC_RS00370	COG1981	membrane
APAC_RS00375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APAC_RS00375	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
APAC_RS00380	COG1187	pseudouridine synthase activity
APAC_RS00385	COG0517	IMP dehydrogenase activity
APAC_RS00385	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APAC_RS00395	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APAC_RS00400	COG0107	imidazoleglycerol-phosphate synthase activity
APAC_RS00415	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APAC_RS00420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APAC_RS00425	COG0724	RNA recognition motif
APAC_RS00430	COG0745	RESPONSE REGULATOR receiver
APAC_RS00435	COG0642	Histidine kinase
APAC_RS00465	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APAC_RS00470	COG2353	YceI-like domain
APAC_RS00480	COG3220	belongs to the UPF0276 family
APAC_RS00490	COG0534	Mate efflux family protein
APAC_RS00495	COG0460	homoserine dehydrogenase
APAC_RS00500	COG0436	Aminotransferase
APAC_RS00520	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APAC_RS00525	COG0254	rRNA binding
APAC_RS00530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APAC_RS00550	COG0109	protoheme IX farnesyltransferase activity
APAC_RS00630	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
APAC_RS00635	COG2992	FlgJ-related protein
APAC_RS00640	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APAC_RS00645	COG0237	dephospho-CoA kinase activity
APAC_RS00650	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
APAC_RS00655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APAC_RS00660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APAC_RS00665	COG1741	Belongs to the pirin family
APAC_RS00670	COG3384	dioxygenase
APAC_RS00685	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
APAC_RS00690	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
APAC_RS00695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APAC_RS00705	COG0505	Belongs to the CarA family
APAC_RS00710	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
APAC_RS00715	COG0745	RESPONSE REGULATOR receiver
APAC_RS00720	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APAC_RS00720	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APAC_RS00735	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
APAC_RS00740	COG0489	protein tyrosine kinase activity
APAC_RS00750	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APAC_RS00750	COG0140	phosphoribosyl-ATP diphosphatase activity
APAC_RS00780	COG0646	methionine synthase
APAC_RS00780	COG1410	methionine synthase
APAC_RS00820	COG1854	S-ribosylhomocysteine lyase activity
APAC_RS00825	COG2201	protein-glutamate methylesterase activity
APAC_RS00830	COG1335	isochorismatase
APAC_RS00840	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APAC_RS00855	COG3180	Ammonia monooxygenase
APAC_RS00865	COG1013	pyruvate-flavodoxin oxidoreductase activity
APAC_RS00870	COG0674	pyruvate-flavodoxin oxidoreductase activity
APAC_RS00880	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
APAC_RS00885	COG0546	phosphoglycolate phosphatase activity
APAC_RS00895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
APAC_RS00900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APAC_RS00925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APAC_RS00930	COG0581	inorganic phosphate transmembrane transporter activity
APAC_RS00935	COG0573	inorganic phosphate transmembrane transporter activity
APAC_RS00940	COG2199	diguanylate cyclase activity
APAC_RS00940	COG2200	EAL domain
APAC_RS00940	COG2203	Gaf domain
APAC_RS00955	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APAC_RS00960	COG0268	Binds directly to 16S ribosomal RNA
APAC_RS00965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APAC_RS00970	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APAC_RS00975	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APAC_RS00980	COG0746	molybdenum cofactor guanylyltransferase activity
APAC_RS01005	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APAC_RS01010	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APAC_RS01050	COG0575	Belongs to the CDS family
APAC_RS01055	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
APAC_RS01075	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APAC_RS01085	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APAC_RS01085	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APAC_RS01095	COG2022	thiamine diphosphate biosynthetic process
APAC_RS01135	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
APAC_RS01160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APAC_RS01175	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APAC_RS01180	COG0585	pseudouridine synthase activity
APAC_RS01195	COG0793	Belongs to the peptidase S41A family
APAC_RS01200	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APAC_RS01205	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APAC_RS01210	COG0047	phosphoribosylformylglycinamidine synthase activity
APAC_RS01220	COG0204	Acyl-transferase
APAC_RS01225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APAC_RS01235	COG0018	arginyl-trna synthetase
APAC_RS01245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APAC_RS01250	COG0126	phosphoglycerate kinase activity
APAC_RS01255	COG0149	triose-phosphate isomerase activity
APAC_RS01260	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APAC_RS01265	COG0019	diaminopimelate decarboxylase activity
APAC_RS01270	COG1605	Chorismate mutase
APAC_RS01270	COG0077	Prephenate dehydratase
APAC_RS01275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APAC_RS01280	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APAC_RS01290	COG0424	maF-like protein
APAC_RS01310	COG0791	NLP P60 protein
APAC_RS01315	COG0791	NLP P60 protein
APAC_RS01330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APAC_RS01335	COG3118	belongs to the thioredoxin family
APAC_RS01340	COG3118	belongs to the thioredoxin family
APAC_RS01345	COG0471	metal ion transport
APAC_RS01350	COG4191	Histidine kinase
APAC_RS01355	COG0745	RESPONSE REGULATOR receiver
APAC_RS01360	COG0492	ferredoxin-NADP+ reductase activity
APAC_RS01365	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APAC_RS01370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APAC_RS01375	COG1242	4 iron, 4 sulfur cluster binding
APAC_RS01390	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APAC_RS01395	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APAC_RS01400	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APAC_RS01405	COG3278	Belongs to the heme-copper respiratory oxidase family
APAC_RS01450	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APAC_RS01475	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APAC_RS01485	COG0157	Belongs to the NadC ModD family
APAC_RS01500	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
APAC_RS01510	COG0083	homoserine kinase activity
APAC_RS01520	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APAC_RS01525	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APAC_RS01530	COG0779	Required for maturation of 30S ribosomal subunits
APAC_RS01535	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APAC_RS01535	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APAC_RS01540	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APAC_RS01545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APAC_RS01550	COG0539	negative regulation of cytoplasmic translation
APAC_RS01550	COG1185	polyribonucleotide nucleotidyltransferase activity
APAC_RS01555	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APAC_RS01560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APAC_RS01565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APAC_RS01565	COG0072	phenylalanine-tRNA ligase activity
APAC_RS01570	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APAC_RS01575	COG0537	adenosine 5'-monophosphoramidase activity
APAC_RS01580	COG0825	malonyl-CoA metabolic process
APAC_RS01585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APAC_RS01590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APAC_RS01600	COG0602	queuosine metabolic process
APAC_RS01610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APAC_RS01615	COG0303	'Molybdopterin
APAC_RS01625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APAC_RS01640	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APAC_RS01650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APAC_RS01655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APAC_RS01660	COG1074	ATP-dependent DNA helicase activity
APAC_RS01665	COG0352	thiamine-phosphate diphosphorylase activity
APAC_RS01670	COG0356	it plays a direct role in the translocation of protons across the membrane
APAC_RS01675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APAC_RS01680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APAC_RS01690	COG0336	Belongs to the RNA methyltransferase TrmD family
APAC_RS01695	COG0335	large ribosomal subunit rRNA binding
APAC_RS01705	COG3610	response to peptide
APAC_RS01710	COG2966	Psort location CytoplasmicMembrane, score
APAC_RS01725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APAC_RS01735	COG0840	transmembrane signaling receptor activity
APAC_RS01755	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APAC_RS01765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APAC_RS01765	COG1648	precorrin-2 dehydrogenase activity
APAC_RS01770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APAC_RS01770	COG1648	precorrin-2 dehydrogenase activity
APAC_RS01780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APAC_RS01785	COG1119	ATPase activity
APAC_RS01790	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APAC_RS01800	COG2404	hydrolase activity, acting on ester bonds
APAC_RS01805	COG1832	CoA-binding protein
APAC_RS01810	COG0642	Histidine kinase
APAC_RS01815	COG0745	RESPONSE REGULATOR receiver
APAC_RS01820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APAC_RS01825	COG0191	fructose-bisphosphate aldolase activity
APAC_RS01830	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APAC_RS01855	COG0840	transmembrane signaling receptor activity
APAC_RS01885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APAC_RS01890	COG1116	anion transmembrane transporter activity
APAC_RS01905	COG1733	regulation of RNA biosynthetic process
APAC_RS01910	COG0604	alcohol dehydrogenase
APAC_RS01950	COG1131	(ABC) transporter
APAC_RS01970	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
APAC_RS01985	COG0535	radical SAM domain protein
APAC_RS01995	COG0439	Biotin carboxylase
APAC_RS02010	COG0745	RESPONSE REGULATOR receiver
APAC_RS02015	COG2205	protein histidine kinase activity
APAC_RS02035	COG0811	peptide transport
APAC_RS02050	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APAC_RS02055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APAC_RS02065	COG0142	geranyltranstransferase activity
APAC_RS02070	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
APAC_RS02075	COG0442	prolyl-tRNA aminoacylation
APAC_RS02080	COG0668	transmembrane transport
APAC_RS02085	COG0617	tRNA 3'-terminal CCA addition
APAC_RS02100	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APAC_RS02105	COG1862	Preprotein translocase
APAC_RS02110	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APAC_RS02115	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APAC_RS02135	COG0495	leucyl-tRNA aminoacylation
APAC_RS02145	COG0285	dihydrofolate synthase activity
APAC_RS02150	COG0739	heme binding
APAC_RS02185	COG2010	Cytochrome c
APAC_RS02190	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
APAC_RS02205	COG0737	Belongs to the 5'-nucleotidase family
APAC_RS02235	COG0326	Molecular chaperone. Has ATPase activity
APAC_RS02260	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APAC_RS02265	COG5001	Diguanylate cyclase
APAC_RS02265	COG4251	negative regulation of phosphorylation
APAC_RS02265	COG2203	Gaf domain
APAC_RS02265	COG3706	GGDEF domain
APAC_RS02270	COG3678	ATP-independent chaperone mediated protein folding
APAC_RS02275	COG0745	RESPONSE REGULATOR receiver
APAC_RS02280	COG0642	Histidine kinase
APAC_RS02285	COG2081	HI0933 family
APAC_RS02305	COG5000	phosphorelay sensor kinase activity
APAC_RS02310	COG1692	metallophosphoesterase
APAC_RS02330	COG2226	methyltransferase
APAC_RS02335	COG1570	exodeoxyribonuclease VII activity
APAC_RS02345	COG0745	RESPONSE REGULATOR receiver
APAC_RS02355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APAC_RS02360	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
APAC_RS02365	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APAC_RS02375	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APAC_RS02380	COG0459	protein refolding
APAC_RS02385	COG2076	Multidrug Resistance protein
APAC_RS02400	COG1408	metallophosphoesterase
APAC_RS02420	COG1136	(ABC) transporter
APAC_RS02435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APAC_RS02440	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APAC_RS02445	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APAC_RS02455	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APAC_RS02460	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APAC_RS02470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APAC_RS02475	COG2264	protein methyltransferase activity
APAC_RS02480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APAC_RS02510	COG0784	Response regulator, receiver
APAC_RS02510	COG3437	response regulator, receiver
APAC_RS02515	COG3706	GGDEF domain
APAC_RS02520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APAC_RS02540	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APAC_RS02545	COG1253	flavin adenine dinucleotide binding
APAC_RS02550	COG3706	GGDEF domain
APAC_RS02555	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APAC_RS02560	COG1090	epimerase
APAC_RS02565	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APAC_RS02575	COG0481	GTPase activity
APAC_RS02590	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APAC_RS02595	COG0482	sulfurtransferase activity
APAC_RS02600	COG0482	sulfurtransferase activity
APAC_RS02605	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APAC_RS02610	COG0006	proline dipeptidase activity
APAC_RS02615	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APAC_RS02620	COG0402	S-adenosylhomocysteine deaminase activity
APAC_RS02625	COG0616	signal peptide processing
APAC_RS02635	COG0280	phosphate acetyltransferase
APAC_RS02640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APAC_RS02650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APAC_RS02670	COG2176	DNA-directed DNA polymerase activity
APAC_RS02680	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APAC_RS02690	COG0745	RESPONSE REGULATOR receiver
APAC_RS02740	COG1058	Belongs to the CinA family
APAC_RS02740	COG1546	Belongs to the CinA family
APAC_RS02745	COG0579	oxidoreductase
APAC_RS02750	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APAC_RS02765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APAC_RS02795	COG0714	Associated with various cellular activities
APAC_RS02800	COG0052	Belongs to the universal ribosomal protein uS2 family
APAC_RS02805	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APAC_RS02810	COG1136	(ABC) transporter
APAC_RS02820	COG0194	GDP metabolic process
APAC_RS02825	COG5002	protein histidine kinase activity
APAC_RS02825	COG5001	Diguanylate cyclase
APAC_RS02830	COG2217	Heavy metal translocating P-type atpase
APAC_RS02845	COG4191	Histidine kinase
APAC_RS02850	COG4608	Belongs to the ABC transporter superfamily
APAC_RS02855	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APAC_RS02865	COG1355	regulation of microtubule-based process
APAC_RS02875	COG1121	(ABC) transporter
APAC_RS02880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APAC_RS02915	COG2996	Protein conserved in bacteria
APAC_RS02920	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APAC_RS02925	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APAC_RS02930	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
APAC_RS02935	COG0210	DNA helicase
APAC_RS02940	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APAC_RS02965	COG3258	Cytochrome c
APAC_RS03025	COG0525	valine-tRNA ligase activity
APAC_RS03035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APAC_RS03050	COG2814	Major facilitator Superfamily
APAC_RS03055	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APAC_RS03080	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APAC_RS03085	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APAC_RS03115	COG0784	Response regulator, receiver
APAC_RS03115	COG2205	protein histidine kinase activity
APAC_RS03120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APAC_RS03145	COG0668	transmembrane transport
APAC_RS03155	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APAC_RS03195	COG1858	cytochrome C peroxidase
APAC_RS03205	COG1028	Short-chain dehydrogenase reductase Sdr
APAC_RS03210	COG0840	transmembrane signaling receptor activity
APAC_RS03235	COG1301	dicarboxylic acid transport
APAC_RS03245	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APAC_RS03260	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
APAC_RS03275	COG0626	cystathionine gamma-synthase activity
APAC_RS03285	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
APAC_RS03295	COG1309	transcriptional regulator
APAC_RS03305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APAC_RS03335	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APAC_RS03340	COG3852	Histidine kinase
APAC_RS03345	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APAC_RS03350	COG0745	RESPONSE REGULATOR receiver
APAC_RS03355	COG0642	Histidine kinase
APAC_RS03370	COG2239	Acts as a magnesium transporter
APAC_RS03380	COG2199	diguanylate cyclase activity
APAC_RS03380	COG2200	EAL domain
APAC_RS03385	COG2151	metal-sulfur cluster biosynthetic enzyme
APAC_RS03390	COG2166	iron-sulfur cluster assembly
APAC_RS03395	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APAC_RS03400	COG0719	Fe-S assembly protein
APAC_RS03405	COG0396	ATPase activity
APAC_RS03410	COG0719	Fe-S assembly protein
APAC_RS03420	COG2906	2 iron, 2 sulfur cluster binding
APAC_RS03420	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
APAC_RS03420	COG0822	iron-sulfur transferase activity
APAC_RS03430	COG3706	GGDEF domain
APAC_RS03450	COG0165	Argininosuccinate lyase
APAC_RS03455	COG0784	Response regulator, receiver
APAC_RS03455	COG0835	chemotaxis
APAC_RS03460	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APAC_RS03465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APAC_RS03470	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APAC_RS03485	COG3657	addiction module killer protein
APAC_RS03490	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APAC_RS03500	COG0556	nucleotide-excision repair
APAC_RS03515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APAC_RS03540	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
APAC_RS03550	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APAC_RS03555	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
APAC_RS03585	COG0438	transferase activity, transferring glycosyl groups
APAC_RS03590	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
APAC_RS03595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APAC_RS03610	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APAC_RS03630	COG3550	peptidyl-serine autophosphorylation
APAC_RS03655	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
APAC_RS03675	COG0698	ribose 5-phosphate isomerase
APAC_RS03680	COG0681	Belongs to the peptidase S26 family
APAC_RS03685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APAC_RS03690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
APAC_RS03695	COG0193	aminoacyl-tRNA hydrolase activity
APAC_RS03710	COG0860	N-Acetylmuramoyl-L-alanine amidase
APAC_RS03720	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APAC_RS03730	COG1758	RNA polymerase activity
APAC_RS03735	COG0528	UMP kinase activity
APAC_RS03745	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APAC_RS03750	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APAC_RS03755	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APAC_RS03765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APAC_RS03770	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APAC_RS03780	COG4191	Histidine kinase
APAC_RS03785	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APAC_RS03795	COG0305	Participates in initiation and elongation during chromosome replication
APAC_RS03805	COG1793	dna ligase
APAC_RS03810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APAC_RS03815	COG0133	tryptophan synthase activity
APAC_RS03825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APAC_RS03845	COG2205	protein histidine kinase activity
APAC_RS03845	COG5002	protein histidine kinase activity
APAC_RS03845	COG0784	Response regulator, receiver
APAC_RS03870	COG3123	guanosine phosphorylase activity
APAC_RS03880	COG2199	diguanylate cyclase activity
APAC_RS03880	COG2203	Gaf domain
APAC_RS03890	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APAC_RS03895	COG0585	pseudouridine synthase activity
APAC_RS03915	COG0632	four-way junction helicase activity
APAC_RS03920	COG1181	Belongs to the D-alanine--D-alanine ligase family
APAC_RS03930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APAC_RS03940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APAC_RS03950	COG0051	transcription antitermination factor activity, RNA binding
APAC_RS03955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APAC_RS03960	COG0088	Forms part of the polypeptide exit tunnel
APAC_RS03965	COG0089	rRNA binding
APAC_RS03970	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APAC_RS03975	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APAC_RS03980	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APAC_RS03985	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APAC_RS03990	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APAC_RS03995	COG0255	Belongs to the universal ribosomal protein uL29 family
APAC_RS04000	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APAC_RS04005	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APAC_RS04010	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APAC_RS04015	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APAC_RS04020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APAC_RS04025	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APAC_RS04030	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APAC_RS04035	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APAC_RS04040	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APAC_RS04045	COG0200	Binds to the 23S rRNA
APAC_RS04050	COG0201	protein transport
APAC_RS04055	COG0024	Methionine aminopeptidase
APAC_RS04060	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APAC_RS04070	COG1573	uracil-dna glycosylase
APAC_RS04080	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APAC_RS04105	COG1032	radical SAM domain protein
APAC_RS04110	COG0563	adenylate kinase activity
APAC_RS04115	COG0563	adenylate kinase activity
APAC_RS04130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APAC_RS04135	COG0322	excinuclease ABC activity
APAC_RS04145	COG0386	Belongs to the glutathione peroxidase family
APAC_RS04155	COG0527	aspartate kinase activity
APAC_RS04160	COG0745	RESPONSE REGULATOR receiver
APAC_RS04165	COG1917	Cupin 2, conserved barrel domain protein
APAC_RS04170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APAC_RS04180	COG4175	Glycine betaine
APAC_RS04185	COG4176	ABC-type proline glycine betaine transport system permease component
APAC_RS04200	COG2113	Glycine betaine
APAC_RS04220	COG0484	heat shock protein binding
APAC_RS04225	COG1620	l-lactate permease
APAC_RS04230	COG0484	heat shock protein binding
APAC_RS04250	COG1472	Belongs to the glycosyl hydrolase 3 family
APAC_RS04260	COG0446	pyridine nucleotide-disulphide oxidoreductase
APAC_RS04265	COG0784	Response regulator, receiver
APAC_RS04265	COG2205	protein histidine kinase activity
APAC_RS04270	COG0745	RESPONSE REGULATOR receiver
APAC_RS04280	COG0784	Response regulator, receiver
APAC_RS04280	COG2205	protein histidine kinase activity
APAC_RS04295	COG0640	Transcriptional regulator
APAC_RS04300	COG0840	transmembrane signaling receptor activity
APAC_RS04375	COG2026	Addiction module toxin, RelE StbE family
APAC_RS04385	COG0829	nickel cation binding
APAC_RS04390	COG0831	urea catabolic process
APAC_RS04390	COG0832	Belongs to the urease beta subunit family
APAC_RS04395	COG0804	urea catabolic process
APAC_RS04400	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
APAC_RS04410	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APAC_RS04430	COG0708	Exodeoxyribonuclease III
APAC_RS04450	COG0456	acetyltransferase
APAC_RS04460	COG0745	RESPONSE REGULATOR receiver
APAC_RS04485	COG1115	amino acid carrier protein
APAC_RS04495	COG2197	response regulator
APAC_RS04500	COG1027	Aspartate ammonia-lyase
APAC_RS04510	COG1528	Iron-storage protein
APAC_RS04515	COG1227	inorganic diphosphatase activity
APAC_RS04520	COG3706	GGDEF domain
APAC_RS04530	COG0010	Belongs to the arginase family
APAC_RS04535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APAC_RS04560	COG2995	paraquat-inducible protein a
APAC_RS04565	COG2995	paraquat-inducible protein a
APAC_RS04570	COG3008	intermembrane lipid transfer
APAC_RS04655	COG0326	Molecular chaperone. Has ATPase activity
APAC_RS04675	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
APAC_RS04685	COG1984	allophanate hydrolase subunit 2
APAC_RS04695	COG2199	diguanylate cyclase activity
APAC_RS04695	COG2200	EAL domain
APAC_RS04695	COG3287	FIST C domain
APAC_RS04715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APAC_RS04725	COG0259	pyridoxamine-phosphate oxidase activity
APAC_RS04730	COG1078	dGTPase activity
APAC_RS04740	COG3287	FIST C domain
APAC_RS04740	COG2200	EAL domain
APAC_RS04740	COG2199	diguanylate cyclase activity
APAC_RS04775	COG2205	protein histidine kinase activity
APAC_RS04775	COG3437	response regulator, receiver
APAC_RS04775	COG3850	Histidine kinase
APAC_RS04775	COG4999	Histidine kinase
APAC_RS04785	COG0745	RESPONSE REGULATOR receiver
APAC_RS04795	COG0210	DNA helicase
APAC_RS04805	COG0840	transmembrane signaling receptor activity
APAC_RS04825	COG1921	L-seryl-tRNASec selenium transferase activity
APAC_RS04855	COG0513	Belongs to the DEAD box helicase family
APAC_RS04870	COG1305	Transglutaminase-like
APAC_RS04885	COG2204	response regulator
APAC_RS04915	COG3383	formate dehydrogenase (NAD+) activity
APAC_RS04925	COG0437	4 iron, 4 sulfur cluster binding
APAC_RS04935	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
APAC_RS04955	COG0303	'Molybdopterin
APAC_RS04960	COG2998	abc-type tungstate transport system, permease component
APAC_RS04965	COG4662	Binding-protein-dependent transport system inner membrane component
APAC_RS04990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APAC_RS05000	COG2204	response regulator
APAC_RS05015	COG0475	glutathione-regulated potassium exporter activity
APAC_RS05015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APAC_RS05020	COG3706	GGDEF domain
APAC_RS05025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APAC_RS05045	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
APAC_RS05070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APAC_RS05075	COG1611	Belongs to the LOG family
APAC_RS05095	COG0739	heme binding
APAC_RS05100	COG0217	transcriptional regulatory protein
APAC_RS05105	COG4783	chaperone-mediated protein folding
APAC_RS05125	COG1049	propionate catabolic process, 2-methylcitrate cycle
APAC_RS05135	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
APAC_RS05145	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
APAC_RS05150	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
APAC_RS05165	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
APAC_RS05175	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
APAC_RS05225	COG0301	tRNA thio-modification
APAC_RS05225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APAC_RS05235	COG2814	Major facilitator Superfamily
APAC_RS05240	COG2354	Protein conserved in bacteria
APAC_RS05270	COG0310	cobalt ion transport
APAC_RS05290	COG2081	HI0933 family
APAC_RS05295	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APAC_RS05300	COG0298	carbon dioxide binding
APAC_RS05305	COG0409	Hydrogenase expression formation protein
APAC_RS05315	COG0309	Hydrogenase expression formation protein (HypE)
APAC_RS05325	COG3328	transposase activity
APAC_RS05330	COG2205	protein histidine kinase activity
APAC_RS05395	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APAC_RS05400	COG2171	N-acyltransferase activity
APAC_RS05405	COG0488	(ABC) transporter
APAC_RS05410	COG0513	Belongs to the DEAD box helicase family
APAC_RS05420	COG0488	(ABC) transporter
APAC_RS05445	COG2884	Cell division ATP-binding protein ftsE
APAC_RS05450	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APAC_RS05460	COG0564	pseudouridine synthase activity
APAC_RS05465	COG0772	Belongs to the SEDS family
APAC_RS05480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APAC_RS05485	COG3123	guanosine phosphorylase activity
APAC_RS05505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APAC_RS05510	COG0066	3-isopropylmalate dehydratase activity
APAC_RS05515	COG0473	3-isopropylmalate dehydrogenase activity
APAC_RS05530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APAC_RS05535	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APAC_RS05540	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APAC_RS05545	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APAC_RS05550	COG0202	RNA polymerase activity
APAC_RS05555	COG0203	ribosomal protein L17
APAC_RS05560	COG0154	amidase activity
APAC_RS05565	COG0517	IMP dehydrogenase activity
APAC_RS05565	COG0516	GMP reductase activity
APAC_RS05595	COG1047	Peptidyl-prolyl cis-trans
APAC_RS05620	COG2391	methyltransferase activity
APAC_RS05645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APAC_RS05660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APAC_RS05665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APAC_RS05700	COG3177	Filamentation induced by cAMP protein fic
APAC_RS05720	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APAC_RS05730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APAC_RS05735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APAC_RS05745	COG0521	Mo-molybdopterin cofactor biosynthetic process
APAC_RS05750	COG0471	metal ion transport
APAC_RS05755	COG1193	negative regulation of DNA recombination
APAC_RS05765	COG3852	Histidine kinase
APAC_RS05780	COG3920	Histidine kinase
APAC_RS05790	COG3706	GGDEF domain
APAC_RS05805	COG0840	transmembrane signaling receptor activity
APAC_RS05810	COG0840	transmembrane signaling receptor activity
APAC_RS05835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APAC_RS05850	COG1881	PFAM PEBP family protein
APAC_RS05860	COG2824	Alkylphosphonate utilization operon protein PhnA
APAC_RS05865	COG0656	L-ascorbic acid biosynthetic process
APAC_RS05885	COG1733	regulation of RNA biosynthetic process
APAC_RS05890	COG0778	Nitroreductase
APAC_RS05895	COG0778	Nitroreductase
APAC_RS05905	COG3437	response regulator, receiver
APAC_RS05905	COG2205	protein histidine kinase activity
APAC_RS05905	COG3850	Histidine kinase
APAC_RS05905	COG4999	Histidine kinase
APAC_RS05910	COG3437	response regulator, receiver
APAC_RS05915	COG3710	Transcriptional regulator
APAC_RS05950	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
APAC_RS05955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APAC_RS05965	COG3437	response regulator, receiver
APAC_RS05965	COG0784	Response regulator, receiver
APAC_RS05975	COG3706	GGDEF domain
APAC_RS05995	COG3046	protein related to deoxyribodipyrimidine photolyase
APAC_RS06010	COG2201	protein-glutamate methylesterase activity
APAC_RS06020	COG2200	EAL domain
APAC_RS06020	COG2199	diguanylate cyclase activity
APAC_RS06020	COG3287	FIST C domain
APAC_RS06030	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APAC_RS06045	COG3040	lipid binding
APAC_RS06060	COG0352	thiamine-phosphate diphosphorylase activity
APAC_RS06060	COG0351	phosphomethylpyrimidine kinase
APAC_RS06070	COG0488	(ABC) transporter
APAC_RS06075	COG1607	acyl-coa hydrolase
APAC_RS06085	COG5002	protein histidine kinase activity
APAC_RS06085	COG3850	Histidine kinase
APAC_RS06105	COG0564	pseudouridine synthase activity
APAC_RS06120	COG0069	glutamate synthase activity
APAC_RS06130	COG2223	nitrite transmembrane transporter activity
APAC_RS06135	COG1028	Short-chain dehydrogenase reductase Sdr
APAC_RS06145	COG2989	Protein conserved in bacteria
APAC_RS06160	COG0628	permease
APAC_RS06175	COG0748	coenzyme F420 binding
APAC_RS06190	COG3338	carbonate dehydratase activity
APAC_RS06195	COG4536	flavin adenine dinucleotide binding
APAC_RS06205	COG2203	Gaf domain
APAC_RS06205	COG2199	diguanylate cyclase activity
APAC_RS06215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APAC_RS06220	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APAC_RS06230	COG1045	serine acetyltransferase
APAC_RS06235	COG1166	arginine decarboxylase activity
APAC_RS06240	COG0124	histidyl-tRNA synthetase
APAC_RS06245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APAC_RS06250	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APAC_RS06255	COG0163	prenyltransferase activity
APAC_RS06265	COG2855	membrane
APAC_RS06270	COG0359	binds to the 23S rRNA
APAC_RS06275	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
APAC_RS06280	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
APAC_RS06290	COG0084	hydrolase, TatD family'
APAC_RS06295	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APAC_RS06300	COG0131	Imidazoleglycerol-phosphate dehydratase
APAC_RS06305	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
APAC_RS06320	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APAC_RS06325	COG0456	acetyltransferase
APAC_RS06335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APAC_RS06375	COG1338	Plays a role in the flagellum-specific transport system
APAC_RS06380	COG0768	penicillin binding
APAC_RS06390	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APAC_RS06400	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
APAC_RS06410	COG1393	Belongs to the ArsC family
APAC_RS06420	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APAC_RS06430	COG0849	cell division
APAC_RS06435	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APAC_RS06440	COG0789	Transcriptional regulator
APAC_RS06445	COG0484	heat shock protein binding
APAC_RS06485	COG4591	ABC-type transport system involved in lipoprotein release permease component
APAC_RS06490	COG0653	protein targeting
APAC_RS06500	COG5001	Diguanylate cyclase
APAC_RS06500	COG3300	MHYT domain
APAC_RS06540	COG0840	transmembrane signaling receptor activity
APAC_RS06545	COG0840	transmembrane signaling receptor activity
APAC_RS06550	COG0628	permease
APAC_RS06555	COG1132	(ABC) transporter
APAC_RS06580	COG0745	RESPONSE REGULATOR receiver
APAC_RS06585	COG0642	Histidine kinase
APAC_RS06615	COG0415	Belongs to the DNA photolyase family
APAC_RS06630	COG3275	phosphorelay sensor kinase activity
APAC_RS06635	COG3279	Response regulator of the LytR AlgR family
APAC_RS06645	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APAC_RS06650	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APAC_RS06660	COG2010	Cytochrome c
APAC_RS06660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APAC_RS06675	COG0300	oxidoreductase activity
APAC_RS06680	COG1064	alcohol dehydrogenase
APAC_RS06685	COG1979	alcohol dehydrogenase
APAC_RS06700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APAC_RS06725	COG0515	serine threonine protein kinase
APAC_RS06725	COG2815	serine threonine protein kinase
APAC_RS06755	COG2207	Transcriptional regulator
APAC_RS06760	COG0513	Belongs to the DEAD box helicase family
APAC_RS06765	COG4191	Histidine kinase
APAC_RS06780	COG0848	biopolymer transport protein
APAC_RS06805	COG1136	(ABC) transporter
APAC_RS06810	COG1136	(ABC) transporter
APAC_RS06810	COG0577	efflux transmembrane transporter activity
APAC_RS06835	COG4771	TonB-dependent receptor
APAC_RS06880	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APAC_RS06950	COG0776	regulation of translation
APAC_RS06960	COG0275	rRNA processing
APAC_RS06975	COG0745	RESPONSE REGULATOR receiver
APAC_RS06980	COG0702	epimerase
APAC_RS07000	COG2199	diguanylate cyclase activity
APAC_RS07020	COG4865	methylaspartate mutase activity
APAC_RS07030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APAC_RS07035	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APAC_RS07040	COG0113	porphobilinogen synthase activity
APAC_RS07045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APAC_RS07050	COG0357	Ribosomal RNA small subunit methyltransferase G
APAC_RS07105	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
APAC_RS07115	COG0511	ligase activity, forming carbon-carbon bonds
APAC_RS07115	COG5016	pyruvate
APAC_RS07125	COG1263	PTS System
APAC_RS07125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APAC_RS07135	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APAC_RS07135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APAC_RS07145	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
APAC_RS07170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APAC_RS07175	COG0612	Peptidase, M16
APAC_RS07180	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
APAC_RS07185	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APAC_RS07190	COG0287	Prephenate dehydrogenase
APAC_RS07210	COG0527	aspartate kinase activity
APAC_RS07215	COG0494	nUDIX hydrolase
APAC_RS07220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APAC_RS07225	COG2890	protein-(glutamine-N5) methyltransferase activity
APAC_RS07230	COG0339	signal peptide processing
APAC_RS07250	COG0582	viral genome integration into host DNA
APAC_RS07255	COG2201	protein-glutamate methylesterase activity
APAC_RS07260	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
APAC_RS07265	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
APAC_RS07270	COG2198	Histidine kinase
APAC_RS07270	COG0643	Histidine kinase
APAC_RS07280	COG1185	polyribonucleotide nucleotidyltransferase activity
APAC_RS07305	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APAC_RS07310	COG0659	secondary active sulfate transmembrane transporter activity
APAC_RS07315	COG1160	GTP binding
APAC_RS07325	COG1196	nuclear chromosome segregation
APAC_RS07325	COG1674	ftsk spoiiie
APAC_RS07330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APAC_RS07335	COG0440	acetolactate synthase activity
APAC_RS07340	COG0028	Belongs to the TPP enzyme family
APAC_RS07360	COG2199	diguanylate cyclase activity
APAC_RS07375	COG3118	belongs to the thioredoxin family
APAC_RS07385	COG1683	Conserved Protein
APAC_RS07390	COG0037	tRNA processing
APAC_RS07420	COG1322	Protein conserved in bacteria
APAC_RS07425	COG0501	Belongs to the peptidase M48B family
APAC_RS07440	COG0824	Thioesterase
APAC_RS07445	COG4895	conserved protein (DUF2196)
APAC_RS07460	COG0667	Aldo Keto reductase
APAC_RS07480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APAC_RS07525	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
APAC_RS07535	COG2949	membrane
APAC_RS07545	COG0848	biopolymer transport protein
APAC_RS07565	COG4771	TonB-dependent receptor
APAC_RS07575	COG0745	RESPONSE REGULATOR receiver
APAC_RS07580	COG1283	sodium-dependent phosphate transmembrane transporter activity
APAC_RS07595	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APAC_RS07600	COG0788	formyltetrahydrofolate deformylase activity
APAC_RS07615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APAC_RS07640	COG0754	glutathionylspermidine amidase activity
APAC_RS07650	COG1663	tetraacyldisaccharide 4'-kinase activity
APAC_RS07655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APAC_RS07660	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
APAC_RS07680	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APAC_RS07685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APAC_RS07690	COG0805	protein transport
APAC_RS07695	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APAC_RS07705	COG0110	maltose O-acetyltransferase activity
APAC_RS07715	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APAC_RS07745	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APAC_RS07755	COG2181	nitrate reductase activity
APAC_RS07755	COG0247	lactate metabolic process
APAC_RS07760	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APAC_RS07780	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APAC_RS07780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APAC_RS07785	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APAC_RS07790	COG2200	EAL domain
APAC_RS07790	COG3287	FIST C domain
APAC_RS07790	COG2199	diguanylate cyclase activity
APAC_RS07795	COG1137	ATPase activity
APAC_RS07800	COG0802	atpase or kinase
APAC_RS07805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APAC_RS07815	COG0137	argininosuccinate synthase activity
APAC_RS07820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APAC_RS07825	COG0439	Biotin carboxylase
APAC_RS07860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APAC_RS07865	COG0484	heat shock protein binding
APAC_RS07880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APAC_RS07885	COG5001	Diguanylate cyclase
APAC_RS07890	COG3706	GGDEF domain
APAC_RS07890	COG2203	Gaf domain
APAC_RS07890	COG4251	negative regulation of phosphorylation
APAC_RS07890	COG5001	Diguanylate cyclase
APAC_RS07895	COG0500	methyltransferase
APAC_RS07900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APAC_RS07900	COG1333	cytochrome c biogenesis protein
APAC_RS07920	COG4191	Histidine kinase
APAC_RS07930	COG2195	Cleaves the N-terminal amino acid of tripeptides
APAC_RS07950	COG2197	response regulator
APAC_RS07965	COG2200	EAL domain
APAC_RS08005	COG2885	chlorophyll binding
APAC_RS08025	COG0840	transmembrane signaling receptor activity
APAC_RS08030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APAC_RS08095	COG1489	DNA binding
APAC_RS08110	COG2133	pyrroloquinoline quinone binding
APAC_RS08125	COG0596	Alpha beta hydrolase
APAC_RS08135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APAC_RS08135	COG0596	Alpha beta hydrolase
APAC_RS08135	COG2226	methyltransferase
APAC_RS08195	COG3201	nicotinamide mononucleotide transporter
APAC_RS08215	COG1187	pseudouridine synthase activity
APAC_RS08220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APAC_RS08220	COG0519	Catalyzes the synthesis of GMP from XMP
APAC_RS08225	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
APAC_RS08230	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APAC_RS08245	COG0436	Aminotransferase
APAC_RS08250	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APAC_RS08255	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
APAC_RS08260	COG0039	L-malate dehydrogenase activity
APAC_RS08335	COG0488	(ABC) transporter
APAC_RS08340	COG1610	YqeY-like protein
APAC_RS08360	COG0300	oxidoreductase activity
APAC_RS08365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APAC_RS08370	COG0742	ribosomal rna small subunit methyltransferase
APAC_RS08375	COG1418	mRNA catabolic process
APAC_RS08385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APAC_RS08390	COG0552	protein localization to endoplasmic reticulum
APAC_RS08395	COG3150	esterase
APAC_RS08435	COG1061	Type III restriction enzyme res subunit
APAC_RS08445	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APAC_RS08455	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APAC_RS08460	COG0530	calcium, potassium:sodium antiporter activity
APAC_RS08470	COG1592	Rubrerythrin
APAC_RS08475	COG1592	Rubrerythrin
APAC_RS08485	COG0728	peptidoglycan biosynthetic process
APAC_RS08490	COG1132	(ABC) transporter
APAC_RS08495	COG0167	dihydroorotate dehydrogenase activity
APAC_RS08505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APAC_RS08510	COG1028	Short-chain dehydrogenase reductase Sdr
APAC_RS08515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APAC_RS08520	COG0750	zinc metalloprotease
APAC_RS08525	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APAC_RS08530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APAC_RS08530	COG3153	acetyltransferase
APAC_RS08535	COG0134	indole-3-glycerol-phosphate synthase activity
APAC_RS08545	COG0727	PFAM Uncharacterised protein family (UPF0153)
APAC_RS08550	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
APAC_RS08560	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
APAC_RS08560	COG0674	pyruvate-flavodoxin oxidoreductase activity
APAC_RS08565	COG1013	pyruvate-flavodoxin oxidoreductase activity
APAC_RS08580	COG2176	DNA-directed DNA polymerase activity
APAC_RS08585	COG0135	phosphoribosylanthranilate isomerase activity
APAC_RS08590	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APAC_RS08605	COG0642	Histidine kinase
APAC_RS08610	COG0745	RESPONSE REGULATOR receiver
APAC_RS08620	COG1666	GTP binding
APAC_RS08630	COG2363	Small membrane protein
APAC_RS08640	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
APAC_RS08645	COG2252	PERMEase
APAC_RS08675	COG3706	GGDEF domain
APAC_RS08675	COG4251	negative regulation of phosphorylation
APAC_RS08675	COG2203	Gaf domain
APAC_RS08675	COG5001	Diguanylate cyclase
APAC_RS08695	COG0731	radical SAM domain protein
APAC_RS08700	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APAC_RS08710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APAC_RS08725	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APAC_RS08735	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APAC_RS08755	COG1216	Glycosyl transferase, family 2
APAC_RS08760	COG1216	Glycosyl transferase, family 2
APAC_RS08820	COG0438	transferase activity, transferring glycosyl groups
APAC_RS08825	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
APAC_RS08845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APAC_RS08850	COG0483	inositol monophosphate 1-phosphatase activity
APAC_RS08855	COG0493	'glutamate synthase
APAC_RS08860	COG0069	glutamate synthase activity
APAC_RS08860	COG0067	glutamate synthase
APAC_RS08860	COG0070	glutamate synthase
APAC_RS08890	COG1136	(ABC) transporter
APAC_RS08925	COG0328	RNA-DNA hybrid ribonuclease activity
APAC_RS08945	COG0419	ATPase involved in DNA repair
APAC_RS08950	COG0420	3'-5' exonuclease activity
APAC_RS08985	COG0745	RESPONSE REGULATOR receiver
APAC_RS09065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APAC_RS09120	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APAC_RS09230	COG0582	viral genome integration into host DNA
APAC_RS09245	COG0284	orotidine-5'-phosphate decarboxylase activity
APAC_RS09250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APAC_RS09255	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APAC_RS09260	COG2877	3-deoxy-8-phosphooctulonate synthase activity
APAC_RS09285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APAC_RS09315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APAC_RS09350	COG1459	type II secretion system
APAC_RS09365	COG1739	Uncharacterized protein family UPF0029
APAC_RS09375	COG0196	riboflavin kinase activity
APAC_RS09385	COG2226	methyltransferase
APAC_RS09390	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APAC_RS09400	COG0277	FAD linked oxidase domain protein
APAC_RS09435	COG0166	Belongs to the GPI family
APAC_RS09440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APAC_RS09445	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APAC_RS09450	COG1047	Peptidyl-prolyl cis-trans
APAC_RS09465	COG0823	Involved in the tonB-independent uptake of proteins
APAC_RS09475	COG0848	biopolymer transport protein
APAC_RS09480	COG0811	peptide transport
APAC_RS09485	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APAC_RS09490	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APAC_RS09495	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APAC_RS09500	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APAC_RS09505	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APAC_RS09510	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APAC_RS09520	COG1475	DNA binding
APAC_RS09525	COG1192	Involved in chromosome partitioning
APAC_RS09530	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
APAC_RS09530	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
APAC_RS09540	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APAC_RS09545	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APAC_RS09550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APAC_RS09555	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APAC_RS09560	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APAC_RS09570	COG0358	DNA primase activity
APAC_RS09575	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
APAC_RS09580	COG0328	RNA-DNA hybrid ribonuclease activity
APAC_RS09585	COG0571	ribonuclease III activity
APAC_RS09590	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APAC_RS09600	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APAC_RS09605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APAC_RS09620	COG0501	Belongs to the peptidase M48B family
APAC_RS09630	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APAC_RS09640	COG0706	membrane insertase activity
APAC_RS09645	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
APAC_RS09650	COG0594	ribonuclease P activity
APAC_RS09655	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APAC_RS09660	COG0542	response to heat
APAC_RS09665	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APAC_RS09695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APAC_RS09700	COG4191	Histidine kinase
APAC_RS09725	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APAC_RS09730	COG0179	Fumarylacetoacetate (FAA) hydrolase
APAC_RS09745	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APAC_RS09755	COG0138	bifunctional purine biosynthesis protein purh
APAC_RS09760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APAC_RS09770	COG1196	nuclear chromosome segregation
APAC_RS09770	COG0741	lytic transglycosylase activity
APAC_RS09770	COG0739	heme binding
APAC_RS09775	COG2239	Acts as a magnesium transporter
APAC_RS09785	COG1459	type II secretion system
APAC_RS09790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APAC_RS09810	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APAC_RS09815	COG0606	chelatase, subunit chli
APAC_RS09825	COG0242	peptide deformylase activity
APAC_RS09830	COG0740	serine-type endopeptidase activity
APAC_RS09835	COG0544	peptidyl-prolyl cis-trans isomerase activity
APAC_RS09840	COG2304	oxidoreductase activity
APAC_RS09875	COG2326	polyphosphate kinase activity
APAC_RS09890	COG1773	rubredoxin
APAC_RS09905	COG0582	viral genome integration into host DNA
APAC_RS09920	COG0328	RNA-DNA hybrid ribonuclease activity
APAC_RS10000	COG3706	GGDEF domain
APAC_RS10005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APAC_RS10025	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APAC_RS10085	COG0716	FMN binding
APAC_RS10100	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
APAC_RS10115	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
APAC_RS10120	COG0159	tryptophan synthase activity
APAC_RS10125	COG0800	Aldolase
APAC_RS10130	COG0129	dihydroxy-acid dehydratase activity
APAC_RS10135	COG0363	glucosamine-6-phosphate deaminase activity
APAC_RS10140	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APAC_RS10150	COG1215	transferase activity, transferring glycosyl groups
APAC_RS10155	COG2379	hydroxypyruvate reductase
APAC_RS10160	COG3769	mannosylglycerate metabolic process
APAC_RS10165	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
APAC_RS10170	COG2255	four-way junction helicase activity
APAC_RS10175	COG0628	permease
APAC_RS10190	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
APAC_RS10200	COG0542	response to heat
APAC_RS10205	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
APAC_RS10210	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APAC_RS10225	COG2030	dehydratase
APAC_RS10245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APAC_RS10275	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APAC_RS10280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APAC_RS10285	COG1157	protein secretion by the type III secretion system
APAC_RS10295	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APAC_RS10325	COG0455	bacterial-type flagellum organization
APAC_RS10330	COG1419	protein localization to endoplasmic reticulum
APAC_RS10355	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
APAC_RS10380	COG1749	Flagellar hook protein flgE
APAC_RS10395	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APAC_RS10405	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APAC_RS10410	COG1766	The M ring may be actively involved in energy transduction
APAC_RS10415	COG1815	bacterial-type flagellum-dependent cell motility
APAC_RS10420	COG4786	Flagellar basal body rod
APAC_RS10430	COG0745	RESPONSE REGULATOR receiver
APAC_RS10450	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APAC_RS10460	COG0228	four-way junction DNA binding
APAC_RS10465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APAC_RS10475	COG1519	Transferase
APAC_RS10475	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APAC_RS10485	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APAC_RS10490	COG0752	glycyl-tRNA synthetase alpha subunit
APAC_RS10500	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APAC_RS10510	COG0826	peptidase U32
APAC_RS10515	COG0840	transmembrane signaling receptor activity
APAC_RS10515	COG0840	transmembrane signaling receptor activity
APAC_RS10520	COG0497	DNA recombination
APAC_RS10525	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APAC_RS10530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APAC_RS10535	COG0049	tRNA binding
APAC_RS10540	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APAC_RS10545	COG1671	Belongs to the UPF0178 family
APAC_RS10640	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APAC_RS10670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APAC_RS10685	COG3328	transposase activity
APAC_RS10695	COG4191	Histidine kinase
APAC_RS10725	COG0582	viral genome integration into host DNA
APAC_RS10740	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APAC_RS10745	COG0085	RNA polymerase activity
APAC_RS10750	COG0222	ribosome binding
APAC_RS10755	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APAC_RS10760	COG0081	regulation of translation
APAC_RS10765	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APAC_RS10770	COG0250	Participates in transcription elongation, termination and antitermination
APAC_RS10785	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APAC_RS10790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APAC_RS10815	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APAC_RS10820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APAC_RS10825	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APAC_RS10830	COG0444	Belongs to the ABC transporter superfamily
APAC_RS10835	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APAC_RS10840	COG0174	glutamine synthetase
APAC_RS10850	COG3706	GGDEF domain
APAC_RS10855	COG0314	molybdopterin synthase activity
APAC_RS10865	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
APAC_RS10870	COG1968	undecaprenyl-diphosphatase activity
APAC_RS10880	COG0772	Belongs to the SEDS family
APAC_RS10885	COG0768	penicillin binding
APAC_RS10890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APAC_RS10930	COG0512	Glutamine amidotransferase of anthranilate synthase
APAC_RS10935	COG1840	ABC-type Fe3 transport system, periplasmic component
APAC_RS10945	COG3842	ATPase activity
APAC_RS10950	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
APAC_RS10955	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APAC_RS10960	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APAC_RS10965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APAC_RS10970	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APAC_RS10970	COG0649	NAD binding
APAC_RS10985	COG0372	Belongs to the citrate synthase family
APAC_RS10990	COG1034	ATP synthesis coupled electron transport
APAC_RS10995	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
APAC_RS11000	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APAC_RS11010	COG0713	ATP synthesis coupled electron transport
APAC_RS11015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APAC_RS11025	COG1007	ATP synthesis coupled electron transport
APAC_RS11035	COG1053	succinate dehydrogenase
APAC_RS11040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APAC_RS11050	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
APAC_RS11055	COG1451	nucleotide metabolic process
APAC_RS11065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APAC_RS11110	COG2183	response to ionizing radiation
APAC_RS11120	COG3328	transposase activity
APAC_RS11125	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APAC_RS11140	COG0251	oxidation-reduction process
APAC_RS11145	COG2885	chlorophyll binding
APAC_RS11170	COG0500	methyltransferase
APAC_RS11175	COG0514	ATP-dependent DNA helicase (RecQ)
APAC_RS11200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APAC_RS11210	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
APAC_RS11230	COG0372	Belongs to the citrate synthase family
APAC_RS11235	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APAC_RS11245	COG3706	GGDEF domain
APAC_RS11255	COG0181	hydroxymethylbilane synthase activity
APAC_RS11265	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APAC_RS11270	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
APAC_RS11280	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APAC_RS11285	COG0450	alkyl hydroperoxide reductase
APAC_RS11295	COG0105	UTP biosynthetic process
APAC_RS11305	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APAC_RS11310	COG0416	fatty acid biosynthetic process
APAC_RS11315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APAC_RS11330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APAC_RS11345	COG0540	Belongs to the ATCase OTCase family
APAC_RS11355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APAC_RS11365	COG0469	pyruvate kinase activity
APAC_RS11385	COG0792	nuclease activity
APAC_RS11390	COG0477	Major facilitator Superfamily
APAC_RS11395	COG0156	8-amino-7-oxononanoate synthase activity
APAC_RS11400	COG0288	reversible hydration of carbon dioxide
APAC_RS11410	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
APAC_RS11420	COG2121	Domain of unknown function (DUF374)
APAC_RS11425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APAC_RS11435	COG0195	Participates in both transcription termination and antitermination
APAC_RS11440	COG0215	cysteine-tRNA ligase activity
APAC_RS11445	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APAC_RS11455	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APAC_RS11460	COG0629	single-stranded DNA binding
APAC_RS11465	COG0360	Binds together with S18 to 16S ribosomal RNA
APAC_RS11475	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
APAC_RS11480	COG0557	exoribonuclease II activity
APAC_RS11485	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APAC_RS11500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APAC_RS11515	COG0436	Aminotransferase
APAC_RS11540	COG0343	queuine tRNA-ribosyltransferase activity
APAC_RS11545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APAC_RS11550	COG0508	dehydrogenase complex catalyzes the overall conversion of
APAC_RS11555	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APAC_RS11560	COG0095	Lipoate-protein ligase
APAC_RS11565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APAC_RS11570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APAC_RS11575	COG1393	Belongs to the ArsC family
APAC_RS11600	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
APAC_RS11610	COG0560	Phosphoserine phosphatase
APAC_RS11620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APAC_RS11625	COG0736	holo-[acyl-carrier-protein] synthase activity
APAC_RS11630	COG0601	transmembrane transport
APAC_RS11635	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
APAC_RS11640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APAC_RS11660	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
APAC_RS11670	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
APAC_RS11705	COG1706	bacterial-type flagellum-dependent cell motility
APAC_RS11710	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APAC_RS11715	COG0418	dihydroorotase activity
APAC_RS11725	COG0004	ammonium transporteR
APAC_RS11735	COG0004	ammonium transporteR
APAC_RS11745	COG1116	anion transmembrane transporter activity
APAC_RS11755	COG1116	anion transmembrane transporter activity
APAC_RS11755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APAC_RS11760	COG0243	molybdopterin cofactor binding
APAC_RS11765	COG0745	RESPONSE REGULATOR receiver
APAC_RS11770	COG4191	Histidine kinase
APAC_RS11785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APAC_RS11810	COG0745	RESPONSE REGULATOR receiver
APAC_RS11830	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
APAC_RS11835	COG0204	Acyl-transferase
APAC_RS11835	COG0318	PFAM AMP-dependent synthetase and ligase
APAC_RS11845	COG0659	secondary active sulfate transmembrane transporter activity
APAC_RS11860	COG0348	domain, Protein
APAC_RS11865	COG4191	Histidine kinase
APAC_RS11870	COG3279	Response regulator of the LytR AlgR family
APAC_RS11885	COG2059	Chromate
APAC_RS11890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APAC_RS11915	COG0640	Transcriptional regulator
APAC_RS11930	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APAC_RS11935	COG2205	protein histidine kinase activity
APAC_RS11945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APAC_RS11960	COG0745	RESPONSE REGULATOR receiver
APAC_RS11990	COG0628	permease
APAC_RS11995	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APAC_RS12000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APAC_RS12015	COG2814	Major facilitator Superfamily
APAC_RS12045	COG1278	Cold shock
APAC_RS12065	COG0129	dihydroxy-acid dehydratase activity
APAC_RS12070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APAC_RS12075	COG0745	RESPONSE REGULATOR receiver
APAC_RS12080	COG0642	Histidine kinase
APAC_RS12095	COG1492	cobalamin metabolic process
APAC_RS12110	COG0642	Histidine kinase
APAC_RS12130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APAC_RS12145	COG2095	MarC family integral membrane protein
APAC_RS12150	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
APAC_RS12155	COG4232	protein-disulfide reductase activity
APAC_RS12170	COG3608	succinylglutamate desuccinylase aspartoacylase
APAC_RS12175	COG0189	ligase activity
APAC_RS12190	COG2199	diguanylate cyclase activity
APAC_RS12190	COG3287	FIST C domain
APAC_RS12190	COG2200	EAL domain
APAC_RS12195	COG0688	phosphatidylethanolamine metabolic process
APAC_RS12215	COG0443	Heat shock 70 kDa protein
APAC_RS12220	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APAC_RS12240	COG2204	response regulator
APAC_RS12260	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
APAC_RS12265	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APAC_RS12270	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APAC_RS12275	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APAC_RS12285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APAC_RS12290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APAC_RS12320	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APAC_RS12325	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APAC_RS12330	COG2089	acid synthase
APAC_RS12340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APAC_RS12355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APAC_RS12360	COG0148	phosphopyruvate hydratase activity
APAC_RS12375	COG0569	domain protein
APAC_RS12375	COG0475	glutathione-regulated potassium exporter activity
APAC_RS12380	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APAC_RS12400	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
APAC_RS12410	COG1007	ATP synthesis coupled electron transport
APAC_RS12420	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APAC_RS12425	COG0713	ATP synthesis coupled electron transport
APAC_RS12430	COG0839	Belongs to the complex I subunit 6 family
APAC_RS12435	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APAC_RS12440	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
APAC_RS12460	COG0649	NAD binding
APAC_RS12465	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APAC_RS12470	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APAC_RS12475	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APAC_RS12485	COG1222	aaa ATPase
APAC_RS12500	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
APAC_RS12505	COG1252	NADH dehydrogenase
APAC_RS12510	COG2199	diguanylate cyclase activity
APAC_RS12510	COG3287	FIST C domain
APAC_RS12510	COG2200	EAL domain
APAC_RS12520	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APAC_RS12525	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APAC_RS12530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APAC_RS12535	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APAC_RS12540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APAC_RS12560	COG0445	tRNA wobble uridine modification
APAC_RS12585	COG3328	transposase activity
APAC_RS12610	COG1271	oxidase subunit
APAC_RS12625	COG0450	alkyl hydroperoxide reductase
APAC_RS12630	COG1230	cation diffusion facilitator family transporter
APAC_RS12645	COG3328	transposase activity
APAC_RS12675	COG0504	CTP synthase activity
APAC_RS12680	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
APAC_RS12680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APAC_RS12710	COG0587	DNA-directed DNA polymerase activity
APAC_RS12715	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APAC_RS12730	COG0315	cyclic pyranopterin monophosphate synthase activity
APAC_RS12735	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APAC_RS12790	COG0670	Belongs to the BI1 family
APAC_RS12795	COG0352	thiamine-phosphate diphosphorylase activity
APAC_RS12805	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APAC_RS12810	COG0233	cytoplasmic translational termination
APAC_RS12815	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APAC_RS12845	COG3264	Mechanosensitive ion channel
APAC_RS12845	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
APAC_RS12850	COG2239	Acts as a magnesium transporter
APAC_RS12855	COG0598	Magnesium transport protein CorA
APAC_RS12860	COG3022	response to hydroperoxide
APAC_RS12880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APAC_RS12885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APAC_RS12890	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APAC_RS12905	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APAC_RS12910	COG1012	belongs to the aldehyde dehydrogenase family
APAC_RS12920	COG1704	LemA family
APAC_RS12935	COG0546	phosphoglycolate phosphatase activity
APAC_RS12955	COG2814	Major facilitator Superfamily
APAC_RS12960	COG2814	Major facilitator Superfamily
APAC_RS12975	COG0415	Belongs to the DNA photolyase family
APAC_RS12995	COG1278	Cold shock
APAC_RS13010	COG2081	HI0933 family
APAC_RS13030	COG1959	2 iron, 2 sulfur cluster binding
APAC_RS13045	COG0175	sulfate reduction
APAC_RS13050	COG0175	sulfate reduction
APAC_RS13055	COG2895	sulfate adenylyltransferase (ATP) activity
APAC_RS13065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APAC_RS13070	COG1408	metallophosphoesterase
APAC_RS13085	COG0071	Belongs to the small heat shock protein (HSP20) family
APAC_RS13095	COG2308	Evidence 4 Homologs of previously reported genes of
APAC_RS13110	COG2308	Evidence 4 Homologs of previously reported genes of
APAC_RS13115	COG1217	gtp-binding protein TYPA
APAC_RS13145	COG0745	RESPONSE REGULATOR receiver
APAC_RS13150	COG0642	Histidine kinase
APAC_RS13160	COG2066	Belongs to the glutaminase family
APAC_RS13180	COG0446	pyridine nucleotide-disulphide oxidoreductase
APAC_RS13190	COG2860	membrane
APAC_RS13200	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APAC_RS13205	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group