locus-tag	class	description
APORC_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APORC_RS00010	COG0592	DNA-directed DNA polymerase activity
APORC_RS00015	COG0187	DNA topoisomerase II activity
APORC_RS00025	COG1238	metal cluster binding
APORC_RS00035	COG0500	methyltransferase
APORC_RS00040	COG3842	ATPase activity
APORC_RS00075	COG0564	pseudouridine synthase activity
APORC_RS00080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APORC_RS00085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APORC_RS00090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APORC_RS00105	COG0604	alcohol dehydrogenase
APORC_RS00110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APORC_RS00115	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APORC_RS00125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APORC_RS00125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APORC_RS00130	COG0511	ligase activity, forming carbon-carbon bonds
APORC_RS00135	COG0439	Biotin carboxylase
APORC_RS00140	COG0513	Belongs to the DEAD box helicase family
APORC_RS00145	COG0306	phosphate transporter
APORC_RS00155	COG0367	asparagine synthase
APORC_RS00165	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
APORC_RS00170	COG1981	membrane
APORC_RS00175	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
APORC_RS00175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APORC_RS00180	COG1187	pseudouridine synthase activity
APORC_RS00185	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APORC_RS00185	COG0517	IMP dehydrogenase activity
APORC_RS00195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APORC_RS00200	COG0107	imidazoleglycerol-phosphate synthase activity
APORC_RS00215	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APORC_RS00220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APORC_RS00225	COG0724	RNA recognition motif
APORC_RS00230	COG0745	RESPONSE REGULATOR receiver
APORC_RS00235	COG0642	Histidine kinase
APORC_RS00255	COG2353	YceI-like domain
APORC_RS00260	COG0460	homoserine dehydrogenase
APORC_RS00265	COG0436	Aminotransferase
APORC_RS00275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APORC_RS00280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APORC_RS00285	COG0254	rRNA binding
APORC_RS00290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APORC_RS00300	COG0109	protoheme IX farnesyltransferase activity
APORC_RS00310	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APORC_RS00315	COG4943	cyclic-guanylate-specific phosphodiesterase activity
APORC_RS00320	COG0573	inorganic phosphate transmembrane transporter activity
APORC_RS00330	COG0581	inorganic phosphate transmembrane transporter activity
APORC_RS00335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APORC_RS00350	COG0745	RESPONSE REGULATOR receiver
APORC_RS00355	COG0642	Histidine kinase
APORC_RS00365	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APORC_RS00370	COG0315	cyclic pyranopterin monophosphate synthase activity
APORC_RS00385	COG0415	Belongs to the DNA photolyase family
APORC_RS00390	COG1233	COG1233 Phytoene dehydrogenase and related
APORC_RS00395	COG3275	phosphorelay sensor kinase activity
APORC_RS00400	COG3279	Response regulator of the LytR AlgR family
APORC_RS00410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APORC_RS00430	COG3040	lipid binding
APORC_RS00445	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APORC_RS00450	COG0587	DNA-directed DNA polymerase activity
APORC_RS00490	COG0693	protein deglycase activity
APORC_RS00505	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
APORC_RS00505	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APORC_RS00510	COG0504	CTP synthase activity
APORC_RS00515	COG0348	domain, Protein
APORC_RS00525	COG0237	dephospho-CoA kinase activity
APORC_RS00530	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APORC_RS00535	COG3852	Histidine kinase
APORC_RS00540	COG0745	RESPONSE REGULATOR receiver
APORC_RS00545	COG0446	pyridine nucleotide-disulphide oxidoreductase
APORC_RS00570	COG2353	YceI-like domain
APORC_RS00580	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
APORC_RS00585	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
APORC_RS00590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APORC_RS00600	COG0505	Belongs to the CarA family
APORC_RS00605	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
APORC_RS00615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APORC_RS00615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APORC_RS00625	COG0489	protein tyrosine kinase activity
APORC_RS00635	COG1917	Cupin 2, conserved barrel domain protein
APORC_RS00640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APORC_RS00645	COG0456	acetyltransferase
APORC_RS00660	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APORC_RS00660	COG0140	phosphoribosyl-ATP diphosphatase activity
APORC_RS00685	COG0646	methionine synthase
APORC_RS00685	COG1410	methionine synthase
APORC_RS00705	COG1854	S-ribosylhomocysteine lyase activity
APORC_RS00720	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APORC_RS00745	COG0546	phosphoglycolate phosphatase activity
APORC_RS00760	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
APORC_RS00770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APORC_RS00780	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APORC_RS00785	COG0352	thiamine-phosphate diphosphorylase activity
APORC_RS00790	COG0352	thiamine-phosphate diphosphorylase activity
APORC_RS00790	COG0351	phosphomethylpyrimidine kinase
APORC_RS00810	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
APORC_RS00850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
APORC_RS00855	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APORC_RS00860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APORC_RS00865	COG0268	Binds directly to 16S ribosomal RNA
APORC_RS00870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APORC_RS00875	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APORC_RS00880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APORC_RS00885	COG0746	molybdenum cofactor guanylyltransferase activity
APORC_RS00900	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APORC_RS00905	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APORC_RS00915	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APORC_RS00950	COG0575	Belongs to the CDS family
APORC_RS00955	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
APORC_RS00970	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APORC_RS01035	COG0840	transmembrane signaling receptor activity
APORC_RS01040	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APORC_RS01070	COG0640	Transcriptional regulator
APORC_RS01075	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
APORC_RS01080	COG2059	Chromate
APORC_RS01095	COG0347	Belongs to the P(II) protein family
APORC_RS01105	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APORC_RS01110	COG1706	bacterial-type flagellum-dependent cell motility
APORC_RS01120	COG1987	bacterial-type flagellum assembly
APORC_RS01145	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
APORC_RS01175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APORC_RS01185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
APORC_RS01190	COG0601	transmembrane transport
APORC_RS01195	COG0736	holo-[acyl-carrier-protein] synthase activity
APORC_RS01205	COG0786	glutamate:sodium symporter activity
APORC_RS01210	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APORC_RS01215	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
APORC_RS01215	COG0646	methionine synthase
APORC_RS01220	COG0560	Phosphoserine phosphatase
APORC_RS01230	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
APORC_RS01235	COG1393	Belongs to the ArsC family
APORC_RS01240	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APORC_RS01245	COG0343	queuine tRNA-ribosyltransferase activity
APORC_RS01270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APORC_RS01275	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APORC_RS01280	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APORC_RS01285	COG3278	Belongs to the heme-copper respiratory oxidase family
APORC_RS01300	COG2010	Cytochrome c
APORC_RS01350	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APORC_RS01365	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APORC_RS01375	COG0157	Belongs to the NadC ModD family
APORC_RS01390	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
APORC_RS01400	COG0083	homoserine kinase activity
APORC_RS01410	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APORC_RS01415	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APORC_RS01420	COG0779	Required for maturation of 30S ribosomal subunits
APORC_RS01425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APORC_RS01425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APORC_RS01440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APORC_RS01445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APORC_RS01450	COG1185	polyribonucleotide nucleotidyltransferase activity
APORC_RS01450	COG0539	negative regulation of cytoplasmic translation
APORC_RS01455	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APORC_RS01460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APORC_RS01465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APORC_RS01465	COG0072	phenylalanine-tRNA ligase activity
APORC_RS01470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APORC_RS01475	COG0537	adenosine 5'-monophosphoramidase activity
APORC_RS01490	COG0825	malonyl-CoA metabolic process
APORC_RS01495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APORC_RS01500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APORC_RS01520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APORC_RS01530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APORC_RS01535	COG0723	plastoquinol--plastocyanin reductase activity
APORC_RS01540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APORC_RS01545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APORC_RS01550	COG0210	DNA helicase
APORC_RS01555	COG0356	it plays a direct role in the translocation of protons across the membrane
APORC_RS01560	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APORC_RS01565	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APORC_RS01575	COG0336	Belongs to the RNA methyltransferase TrmD family
APORC_RS01580	COG0335	large ribosomal subunit rRNA binding
APORC_RS01585	COG0586	Pfam SNARE associated Golgi protein
APORC_RS01595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APORC_RS01605	COG0251	oxidation-reduction process
APORC_RS01635	COG3328	transposase activity
APORC_RS01665	COG1840	ABC-type Fe3 transport system, periplasmic component
APORC_RS01670	COG0512	Glutamine amidotransferase of anthranilate synthase
APORC_RS01690	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APORC_RS01695	COG0049	tRNA binding
APORC_RS01700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APORC_RS01705	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APORC_RS01710	COG0497	DNA recombination
APORC_RS01715	COG0840	transmembrane signaling receptor activity
APORC_RS01715	COG0840	transmembrane signaling receptor activity
APORC_RS01720	COG0826	peptidase U32
APORC_RS01730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APORC_RS01740	COG0752	glycyl-tRNA synthetase alpha subunit
APORC_RS01745	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APORC_RS01755	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APORC_RS01755	COG1519	Transferase
APORC_RS01760	COG0564	pseudouridine synthase activity
APORC_RS01765	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APORC_RS01770	COG0228	four-way junction DNA binding
APORC_RS01780	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APORC_RS01800	COG0745	RESPONSE REGULATOR receiver
APORC_RS01810	COG4786	Flagellar basal body rod
APORC_RS01815	COG1815	bacterial-type flagellum-dependent cell motility
APORC_RS01820	COG1766	The M ring may be actively involved in energy transduction
APORC_RS01825	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APORC_RS01835	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APORC_RS01845	COG1749	Flagellar hook protein flgE
APORC_RS01875	COG3951	Flagellar rod assembly protein muramidase FlgJ
APORC_RS01890	COG1419	protein localization to endoplasmic reticulum
APORC_RS01895	COG0455	bacterial-type flagellum organization
APORC_RS01905	COG1677	Flagellar hook-basal body complex protein FliE
APORC_RS01925	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APORC_RS01935	COG1157	protein secretion by the type III secretion system
APORC_RS01945	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APORC_RS01955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APORC_RS01960	COG0482	sulfurtransferase activity
APORC_RS01965	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APORC_RS01970	COG0006	proline dipeptidase activity
APORC_RS01980	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APORC_RS01985	COG0402	S-adenosylhomocysteine deaminase activity
APORC_RS01990	COG0616	signal peptide processing
APORC_RS01995	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APORC_RS02000	COG0280	phosphate acetyltransferase
APORC_RS02005	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APORC_RS02010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APORC_RS02020	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APORC_RS02030	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APORC_RS02040	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
APORC_RS02050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APORC_RS02110	COG0579	oxidoreductase
APORC_RS02115	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APORC_RS02130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APORC_RS02135	COG0052	Belongs to the universal ribosomal protein uS2 family
APORC_RS02140	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APORC_RS02145	COG1136	(ABC) transporter
APORC_RS02155	COG0194	GDP metabolic process
APORC_RS02160	COG4753	response regulator
APORC_RS02160	COG2207	Transcriptional regulator
APORC_RS02165	COG2217	Heavy metal translocating P-type atpase
APORC_RS02185	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APORC_RS02195	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APORC_RS02200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APORC_RS02205	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APORC_RS02210	COG0352	thiamine-phosphate diphosphorylase activity
APORC_RS02215	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APORC_RS02225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APORC_RS02230	COG2264	protein methyltransferase activity
APORC_RS02235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APORC_RS02240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APORC_RS02255	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APORC_RS02260	COG1648	precorrin-2 dehydrogenase activity
APORC_RS02260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APORC_RS02275	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APORC_RS02280	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APORC_RS02295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APORC_RS02305	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
APORC_RS02310	COG0481	GTPase activity
APORC_RS02320	COG2217	Heavy metal translocating P-type atpase
APORC_RS02325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APORC_RS02350	COG2030	dehydratase
APORC_RS02365	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APORC_RS02370	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
APORC_RS02375	COG0542	response to heat
APORC_RS02415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APORC_RS02425	COG0772	Belongs to the SEDS family
APORC_RS02435	COG1968	undecaprenyl-diphosphatase activity
APORC_RS02440	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
APORC_RS02450	COG0314	molybdopterin synthase activity
APORC_RS02460	COG0174	glutamine synthetase
APORC_RS02485	COG0525	valine-tRNA ligase activity
APORC_RS02490	COG2814	Major facilitator Superfamily
APORC_RS02495	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APORC_RS02515	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APORC_RS02520	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APORC_RS02525	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APORC_RS02535	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APORC_RS02540	COG1136	(ABC) transporter
APORC_RS02540	COG0577	efflux transmembrane transporter activity
APORC_RS02545	COG0577	efflux transmembrane transporter activity
APORC_RS02545	COG1136	(ABC) transporter
APORC_RS02560	COG0811	peptide transport
APORC_RS02565	COG0848	biopolymer transport protein
APORC_RS02570	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
APORC_RS02580	COG3077	Addiction module antitoxin, RelB DinJ family
APORC_RS02590	COG0439	Biotin carboxylase
APORC_RS02595	COG4773	Receptor
APORC_RS02615	COG0542	response to heat
APORC_RS02620	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APORC_RS02630	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
APORC_RS02635	COG0706	membrane insertase activity
APORC_RS02645	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APORC_RS02655	COG0501	Belongs to the peptidase M48B family
APORC_RS02665	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APORC_RS02670	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APORC_RS02675	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APORC_RS02685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APORC_RS02690	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APORC_RS02700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APORC_RS02705	COG0305	Participates in initiation and elongation during chromosome replication
APORC_RS02715	COG4771	TonB-dependent receptor
APORC_RS02735	COG1966	Carbon starvation protein
APORC_RS02740	COG0012	GTP binding
APORC_RS02750	COG3328	transposase activity
APORC_RS02765	COG3123	guanosine phosphorylase activity
APORC_RS02770	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APORC_RS02775	COG0585	pseudouridine synthase activity
APORC_RS02790	COG0632	four-way junction helicase activity
APORC_RS02795	COG1181	Belongs to the D-alanine--D-alanine ligase family
APORC_RS02805	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APORC_RS02820	COG3201	nicotinamide mononucleotide transporter
APORC_RS02845	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APORC_RS02850	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APORC_RS02850	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APORC_RS02875	COG3328	transposase activity
APORC_RS02880	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APORC_RS02895	COG0730	response to heat
APORC_RS02900	COG1045	serine acetyltransferase
APORC_RS02905	COG1166	arginine decarboxylase activity
APORC_RS02910	COG0124	histidyl-tRNA synthetase
APORC_RS02915	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APORC_RS02920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APORC_RS02925	COG0163	prenyltransferase activity
APORC_RS02935	COG0359	binds to the 23S rRNA
APORC_RS02940	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
APORC_RS02945	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
APORC_RS02955	COG0084	hydrolase, TatD family'
APORC_RS02960	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APORC_RS02965	COG0131	Imidazoleglycerol-phosphate dehydratase
APORC_RS02970	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
APORC_RS02985	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APORC_RS02990	COG0456	acetyltransferase
APORC_RS03000	COG0051	transcription antitermination factor activity, RNA binding
APORC_RS03005	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APORC_RS03010	COG0088	Forms part of the polypeptide exit tunnel
APORC_RS03015	COG0089	rRNA binding
APORC_RS03020	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APORC_RS03025	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APORC_RS03030	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APORC_RS03035	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APORC_RS03040	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APORC_RS03045	COG0255	Belongs to the universal ribosomal protein uL29 family
APORC_RS03050	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APORC_RS03055	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APORC_RS03060	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APORC_RS03065	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APORC_RS03070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APORC_RS03075	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APORC_RS03080	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APORC_RS03085	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APORC_RS03090	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APORC_RS03095	COG0200	Binds to the 23S rRNA
APORC_RS03100	COG0201	protein transport
APORC_RS03105	COG0024	Methionine aminopeptidase
APORC_RS03110	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APORC_RS03125	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APORC_RS03135	COG1032	radical SAM domain protein
APORC_RS03140	COG0563	adenylate kinase activity
APORC_RS03145	COG0563	adenylate kinase activity
APORC_RS03165	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APORC_RS03170	COG0840	transmembrane signaling receptor activity
APORC_RS03175	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APORC_RS03180	COG0322	excinuclease ABC activity
APORC_RS03185	COG0840	transmembrane signaling receptor activity
APORC_RS03190	COG0753	catalase activity
APORC_RS03210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APORC_RS03220	COG3437	response regulator, receiver
APORC_RS03220	COG0784	Response regulator, receiver
APORC_RS03225	COG1338	Plays a role in the flagellum-specific transport system
APORC_RS03230	COG0768	penicillin binding
APORC_RS03250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APORC_RS03255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APORC_RS03265	COG0564	pseudouridine synthase activity
APORC_RS03270	COG0772	Belongs to the SEDS family
APORC_RS03285	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
APORC_RS03295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APORC_RS03300	COG3123	guanosine phosphorylase activity
APORC_RS03325	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APORC_RS03330	COG0066	3-isopropylmalate dehydratase activity
APORC_RS03335	COG0473	3-isopropylmalate dehydrogenase activity
APORC_RS03350	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APORC_RS03355	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APORC_RS03360	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APORC_RS03365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APORC_RS03370	COG0202	RNA polymerase activity
APORC_RS03375	COG0203	ribosomal protein L17
APORC_RS03380	COG0154	amidase activity
APORC_RS03385	COG0517	IMP dehydrogenase activity
APORC_RS03385	COG0516	GMP reductase activity
APORC_RS03400	COG0484	heat shock protein binding
APORC_RS03405	COG0582	viral genome integration into host DNA
APORC_RS03425	COG1450	Type ii and iii secretion system protein
APORC_RS03480	COG1472	Belongs to the glycosyl hydrolase 3 family
APORC_RS03485	COG0640	Transcriptional regulator
APORC_RS03490	COG2217	Heavy metal translocating P-type atpase
APORC_RS03495	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APORC_RS03505	COG1696	Membrane protein involved in D-alanine export
APORC_RS03515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APORC_RS03520	COG0508	dehydrogenase complex catalyzes the overall conversion of
APORC_RS03525	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APORC_RS03530	COG0095	Lipoate-protein ligase
APORC_RS03535	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APORC_RS03540	COG1944	ATP diphosphatase activity
APORC_RS03545	COG2258	MOSC domain
APORC_RS03550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APORC_RS03555	COG3135	benzoate transporter
APORC_RS03575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APORC_RS03575	COG2169	Transcriptional regulator
APORC_RS03580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APORC_RS03610	COG2166	iron-sulfur cluster assembly
APORC_RS03615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APORC_RS03620	COG0719	Fe-S assembly protein
APORC_RS03625	COG0396	ATPase activity
APORC_RS03630	COG0719	Fe-S assembly protein
APORC_RS03645	COG3706	GGDEF domain
APORC_RS03650	COG0165	Argininosuccinate lyase
APORC_RS03655	COG0784	Response regulator, receiver
APORC_RS03655	COG0835	chemotaxis
APORC_RS03660	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APORC_RS03665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APORC_RS03675	COG0556	nucleotide-excision repair
APORC_RS03680	COG0784	Response regulator, receiver
APORC_RS03680	COG3437	response regulator, receiver
APORC_RS03685	COG3706	GGDEF domain
APORC_RS03685	COG4251	negative regulation of phosphorylation
APORC_RS03685	COG5001	Diguanylate cyclase
APORC_RS03685	COG2203	Gaf domain
APORC_RS03690	COG5002	protein histidine kinase activity
APORC_RS03690	COG2198	Histidine kinase
APORC_RS03690	COG0784	Response regulator, receiver
APORC_RS03695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APORC_RS03710	COG0698	ribose 5-phosphate isomerase
APORC_RS03715	COG0681	Belongs to the peptidase S26 family
APORC_RS03720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APORC_RS03725	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
APORC_RS03730	COG0193	aminoacyl-tRNA hydrolase activity
APORC_RS03745	COG0860	N-Acetylmuramoyl-L-alanine amidase
APORC_RS03755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APORC_RS03760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APORC_RS03765	COG1758	RNA polymerase activity
APORC_RS03770	COG0528	UMP kinase activity
APORC_RS03810	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APORC_RS03825	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
APORC_RS03845	COG0840	transmembrane signaling receptor activity
APORC_RS03860	COG0626	cystathionine gamma-synthase activity
APORC_RS03865	COG1793	dna ligase
APORC_RS03870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APORC_RS03875	COG0133	tryptophan synthase activity
APORC_RS03885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APORC_RS03890	COG0583	DNA-binding transcription factor activity
APORC_RS03960	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APORC_RS03965	COG2171	N-acyltransferase activity
APORC_RS03970	COG0488	(ABC) transporter
APORC_RS04045	COG1137	ATPase activity
APORC_RS04055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APORC_RS04060	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
APORC_RS04065	COG0137	argininosuccinate synthase activity
APORC_RS04175	COG1205	dead DEAH box helicase
APORC_RS04175	COG1111	helicase
APORC_RS04190	COG0556	nucleotide-excision repair
APORC_RS04200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APORC_RS04240	COG0582	viral genome integration into host DNA
APORC_RS04245	COG2183	response to ionizing radiation
APORC_RS04255	COG0708	Exodeoxyribonuclease III
APORC_RS04280	COG0166	Belongs to the GPI family
APORC_RS04320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APORC_RS04340	COG0039	L-malate dehydrogenase activity
APORC_RS04360	COG4591	ABC-type transport system involved in lipoprotein release permease component
APORC_RS04365	COG0653	protein targeting
APORC_RS04370	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
APORC_RS04385	COG1013	pyruvate-flavodoxin oxidoreductase activity
APORC_RS04390	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
APORC_RS04390	COG0674	pyruvate-flavodoxin oxidoreductase activity
APORC_RS04400	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
APORC_RS04405	COG0727	PFAM Uncharacterised protein family (UPF0153)
APORC_RS04415	COG0134	indole-3-glycerol-phosphate synthase activity
APORC_RS04420	COG0861	Integral membrane protein TerC family
APORC_RS04425	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APORC_RS04435	COG0552	protein localization to endoplasmic reticulum
APORC_RS04440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APORC_RS04450	COG1418	mRNA catabolic process
APORC_RS04455	COG0742	ribosomal rna small subunit methyltransferase
APORC_RS04460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APORC_RS04465	COG0300	oxidoreductase activity
APORC_RS04480	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APORC_RS04490	COG1611	Belongs to the LOG family
APORC_RS04500	COG0739	heme binding
APORC_RS04505	COG0217	transcriptional regulatory protein
APORC_RS04510	COG1049	propionate catabolic process, 2-methylcitrate cycle
APORC_RS04515	COG0745	RESPONSE REGULATOR receiver
APORC_RS04530	COG0113	porphobilinogen synthase activity
APORC_RS04535	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APORC_RS04540	COG0357	Ribosomal RNA small subunit methyltransferase G
APORC_RS04580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APORC_RS04605	COG2244	polysaccharide biosynthetic process
APORC_RS04615	COG1216	Glycosyl transferase, family 2
APORC_RS04640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APORC_RS04650	COG2337	Toxic component of a toxin-antitoxin (TA) module
APORC_RS04655	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APORC_RS04670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APORC_RS04675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APORC_RS04680	COG1328	CTP reductase activity
APORC_RS04680	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APORC_RS04695	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
APORC_RS04700	COG2363	Small membrane protein
APORC_RS04705	COG1666	GTP binding
APORC_RS04710	COG0494	nUDIX hydrolase
APORC_RS04720	COG0840	transmembrane signaling receptor activity
APORC_RS04735	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APORC_RS04740	COG0247	lactate metabolic process
APORC_RS04740	COG2181	nitrate reductase activity
APORC_RS04750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APORC_RS04755	COG1663	tetraacyldisaccharide 4'-kinase activity
APORC_RS04760	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APORC_RS04765	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
APORC_RS04785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APORC_RS04790	COG0805	protein transport
APORC_RS04795	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APORC_RS04825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APORC_RS04835	COG1496	oxidoreductase activity
APORC_RS04840	COG0280	phosphate acetyltransferase
APORC_RS04840	COG0281	malic enzyme
APORC_RS04845	COG0788	formyltetrahydrofolate deformylase activity
APORC_RS04850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APORC_RS04855	COG1114	Component of the transport system for branched-chain amino acids
APORC_RS04865	COG1283	sodium-dependent phosphate transmembrane transporter activity
APORC_RS04875	COG0745	RESPONSE REGULATOR receiver
APORC_RS04890	COG0330	HflC and HflK could
APORC_RS04910	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
APORC_RS04920	COG0546	phosphoglycolate phosphatase activity
APORC_RS04930	COG4206	TonB-dependent receptor
APORC_RS04935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APORC_RS04945	COG4139	cobalamin transport
APORC_RS04955	COG1160	GTP binding
APORC_RS04985	COG1185	polyribonucleotide nucleotidyltransferase activity
APORC_RS04995	COG2198	Histidine kinase
APORC_RS04995	COG0643	Histidine kinase
APORC_RS05010	COG2201	protein-glutamate methylesterase activity
APORC_RS05015	COG2223	nitrite transmembrane transporter activity
APORC_RS05080	COG0582	viral genome integration into host DNA
APORC_RS05095	COG0339	signal peptide processing
APORC_RS05100	COG2890	protein-(glutamine-N5) methyltransferase activity
APORC_RS05105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APORC_RS05110	COG0494	nUDIX hydrolase
APORC_RS05115	COG0527	aspartate kinase activity
APORC_RS05130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APORC_RS05135	COG0287	Prephenate dehydrogenase
APORC_RS05140	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APORC_RS05145	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
APORC_RS05150	COG0612	Peptidase, M16
APORC_RS05155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APORC_RS05180	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
APORC_RS05190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APORC_RS05190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APORC_RS05210	COG0511	ligase activity, forming carbon-carbon bonds
APORC_RS05215	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
APORC_RS05250	COG0667	Aldo Keto reductase
APORC_RS05275	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APORC_RS05280	COG0484	heat shock protein binding
APORC_RS05290	COG2833	Protein of unknown function (DUF455)
APORC_RS05295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APORC_RS05300	COG5001	Diguanylate cyclase
APORC_RS05305	COG0500	methyltransferase
APORC_RS05310	COG2195	Cleaves the N-terminal amino acid of tripeptides
APORC_RS05315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APORC_RS05315	COG1333	cytochrome c biogenesis protein
APORC_RS05325	COG2176	DNA-directed DNA polymerase activity
APORC_RS05330	COG0135	phosphoribosylanthranilate isomerase activity
APORC_RS05335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APORC_RS05340	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
APORC_RS05345	COG1253	flavin adenine dinucleotide binding
APORC_RS05350	COG1193	negative regulation of DNA recombination
APORC_RS05355	COG2249	NAD(P)H dehydrogenase (quinone) activity
APORC_RS05365	COG0415	Belongs to the DNA photolyase family
APORC_RS05370	COG1090	epimerase
APORC_RS05385	COG1119	ATPase activity
APORC_RS05390	COG0521	Mo-molybdopterin cofactor biosynthetic process
APORC_RS05400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APORC_RS05405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APORC_RS05415	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APORC_RS05470	COG1674	ftsk spoiiie
APORC_RS05470	COG1196	nuclear chromosome segregation
APORC_RS05475	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APORC_RS05480	COG0440	acetolactate synthase activity
APORC_RS05485	COG0028	Belongs to the TPP enzyme family
APORC_RS05525	COG4166	transmembrane transport
APORC_RS05530	COG0745	RESPONSE REGULATOR receiver
APORC_RS05540	COG0243	molybdopterin cofactor binding
APORC_RS05550	COG0037	tRNA processing
APORC_RS05570	COG0501	Belongs to the peptidase M48B family
APORC_RS05580	COG0824	Thioesterase
APORC_RS05595	COG0446	pyridine nucleotide-disulphide oxidoreductase
APORC_RS05600	COG2204	response regulator
APORC_RS05610	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APORC_RS05615	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APORC_RS05625	COG0303	'Molybdopterin
APORC_RS05635	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
APORC_RS05645	COG0437	4 iron, 4 sulfur cluster binding
APORC_RS05680	COG2204	response regulator
APORC_RS05700	COG1305	Transglutaminase-like
APORC_RS05705	COG0709	Synthesizes selenophosphate from selenide and ATP
APORC_RS05720	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
APORC_RS05740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APORC_RS05740	COG0475	glutathione-regulated potassium exporter activity
APORC_RS05745	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
APORC_RS05755	COG0436	Aminotransferase
APORC_RS05760	COG1451	nucleotide metabolic process
APORC_RS05770	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APORC_RS05775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APORC_RS05775	COG0519	Catalyzes the synthesis of GMP from XMP
APORC_RS05785	COG2336	PFAM SpoVT AbrB
APORC_RS05805	COG0596	Alpha beta hydrolase
APORC_RS05815	COG1132	(ABC) transporter
APORC_RS05830	COG0328	RNA-DNA hybrid ribonuclease activity
APORC_RS05835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APORC_RS05865	COG3210	domain, Protein
APORC_RS05870	COG0745	RESPONSE REGULATOR receiver
APORC_RS05875	COG4191	Histidine kinase
APORC_RS05880	COG3328	transposase activity
APORC_RS05890	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APORC_RS05900	COG0275	rRNA processing
APORC_RS05910	COG0776	regulation of translation
APORC_RS05920	COG0488	(ABC) transporter
APORC_RS05930	COG0739	heme binding
APORC_RS05940	COG1942	4-Oxalocrotonate Tautomerase
APORC_RS05985	COG2814	Major facilitator Superfamily
APORC_RS05995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APORC_RS05995	COG0301	tRNA thio-modification
APORC_RS06015	COG1739	Uncharacterized protein family UPF0029
APORC_RS06025	COG0196	riboflavin kinase activity
APORC_RS06030	COG2226	methyltransferase
APORC_RS06035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APORC_RS06045	COG0277	FAD linked oxidase domain protein
APORC_RS06050	COG1295	ribonuclease BN
APORC_RS06060	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APORC_RS06070	COG2877	3-deoxy-8-phosphooctulonate synthase activity
APORC_RS06090	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APORC_RS06095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APORC_RS06100	COG0284	orotidine-5'-phosphate decarboxylase activity
APORC_RS06120	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APORC_RS06155	COG3645	SOS response
APORC_RS06185	COG0776	regulation of translation
APORC_RS06280	COG1215	transferase activity, transferring glycosyl groups
APORC_RS06310	COG0572	uridine kinase
APORC_RS06385	COG4974	Belongs to the 'phage' integrase family
APORC_RS06405	COG1278	Cold shock
APORC_RS06425	COG0037	tRNA processing
APORC_RS06485	COG4895	conserved protein (DUF2196)
APORC_RS06505	COG3328	transposase activity
APORC_RS06520	COG3736	Type IV secretory pathway, component VirB8
APORC_RS06530	COG2948	multi-organism process
APORC_RS06540	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
APORC_RS06555	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APORC_RS06570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APORC_RS06580	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APORC_RS06590	COG2391	methyltransferase activity
APORC_RS06595	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APORC_RS06600	COG0849	cell division
APORC_RS06610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APORC_RS06625	COG0513	Belongs to the DEAD box helicase family
APORC_RS06635	COG0754	glutathionylspermidine amidase activity
APORC_RS06640	COG1607	acyl-coa hydrolase
APORC_RS06645	COG0488	(ABC) transporter
APORC_RS06655	COG0778	Nitroreductase
APORC_RS06685	COG2855	membrane
APORC_RS06690	COG0583	DNA-binding transcription factor activity
APORC_RS06700	COG2249	NAD(P)H dehydrogenase (quinone) activity
APORC_RS06715	COG2076	Multidrug Resistance protein
APORC_RS06720	COG0642	Histidine kinase
APORC_RS06725	COG0745	RESPONSE REGULATOR receiver
APORC_RS06735	COG3258	Cytochrome c
APORC_RS06745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APORC_RS06745	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
APORC_RS06750	COG0484	heat shock protein binding
APORC_RS06755	COG0789	Transcriptional regulator
APORC_RS06765	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APORC_RS06780	COG0728	peptidoglycan biosynthetic process
APORC_RS06785	COG1132	(ABC) transporter
APORC_RS06790	COG0167	dihydroorotate dehydrogenase activity
APORC_RS06795	COG0612	Peptidase, M16
APORC_RS06800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APORC_RS06805	COG1028	Short-chain dehydrogenase reductase Sdr
APORC_RS06810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APORC_RS06815	COG0750	zinc metalloprotease
APORC_RS06820	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APORC_RS06825	COG0840	transmembrane signaling receptor activity
APORC_RS06830	COG0840	transmembrane signaling receptor activity
APORC_RS06840	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APORC_RS06860	COG0716	FMN binding
APORC_RS06875	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
APORC_RS06885	COG0159	tryptophan synthase activity
APORC_RS06890	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
APORC_RS06895	COG2255	four-way junction helicase activity
APORC_RS06900	COG0628	permease
APORC_RS06950	COG0598	Magnesium transport protein CorA
APORC_RS06975	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APORC_RS06980	COG0606	chelatase, subunit chli
APORC_RS06990	COG0242	peptide deformylase activity
APORC_RS06995	COG0740	serine-type endopeptidase activity
APORC_RS07000	COG0544	peptidyl-prolyl cis-trans isomerase activity
APORC_RS07005	COG2326	polyphosphate kinase activity
APORC_RS07030	COG0582	viral genome integration into host DNA
APORC_RS07035	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APORC_RS07055	COG0732	type I restriction modification DNA specificity domain
APORC_RS07125	COG0776	regulation of translation
APORC_RS07175	COG2234	aminopeptidase activity
APORC_RS07195	COG1401	restriction endodeoxyribonuclease activity
APORC_RS07380	COG1858	cytochrome C peroxidase
APORC_RS07410	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APORC_RS07455	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APORC_RS07465	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APORC_RS07480	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APORC_RS07490	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APORC_RS07500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APORC_RS07505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APORC_RS07510	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
APORC_RS07510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APORC_RS07515	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
APORC_RS07520	COG1368	sulfuric ester hydrolase activity
APORC_RS07525	COG0859	PFAM glycosyl transferase family 9
APORC_RS07535	COG2194	sulfuric ester hydrolase activity
APORC_RS07540	COG0463	Glycosyl transferase, family 2
APORC_RS07565	COG3083	sulfuric ester hydrolase activity
APORC_RS07580	COG0859	PFAM glycosyl transferase family 9
APORC_RS07590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APORC_RS07595	COG0483	inositol monophosphate 1-phosphatase activity
APORC_RS07640	COG1921	L-seryl-tRNASec selenium transferase activity
APORC_RS07690	COG2200	EAL domain
APORC_RS07690	COG2199	diguanylate cyclase activity
APORC_RS07690	COG3287	FIST C domain
APORC_RS07695	COG0259	pyridoxamine-phosphate oxidase activity
APORC_RS07705	COG0513	Belongs to the DEAD box helicase family
APORC_RS07715	COG0326	Molecular chaperone. Has ATPase activity
APORC_RS07720	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APORC_RS07720	COG2755	lipolytic protein G-D-S-L family
APORC_RS07765	COG4335	DNA alkylation repair
APORC_RS07770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APORC_RS07775	COG0010	Belongs to the arginase family
APORC_RS07780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APORC_RS07785	COG2207	Transcriptional regulator
APORC_RS07790	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APORC_RS07795	COG0668	transmembrane transport
APORC_RS07800	COG1227	inorganic diphosphatase activity
APORC_RS07805	COG3012	SEC-C Motif Domain Protein
APORC_RS07825	COG1027	Aspartate ammonia-lyase
APORC_RS07830	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APORC_RS07835	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APORC_RS07840	COG1047	Peptidyl-prolyl cis-trans
APORC_RS07850	COG2885	chlorophyll binding
APORC_RS07855	COG0823	Involved in the tonB-independent uptake of proteins
APORC_RS07865	COG0848	biopolymer transport protein
APORC_RS07870	COG0811	peptide transport
APORC_RS07875	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APORC_RS07880	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APORC_RS07885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APORC_RS07890	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APORC_RS07895	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APORC_RS07900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APORC_RS07910	COG1475	DNA binding
APORC_RS07915	COG1192	Involved in chromosome partitioning
APORC_RS07920	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
APORC_RS07920	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
APORC_RS07930	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APORC_RS07935	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APORC_RS07940	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APORC_RS07945	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APORC_RS07950	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APORC_RS07955	COG0358	DNA primase activity
APORC_RS07965	COG0571	ribonuclease III activity
APORC_RS07970	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APORC_RS07980	COG2326	polyphosphate kinase activity
APORC_RS07995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APORC_RS08045	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
APORC_RS08055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APORC_RS08060	COG0179	Fumarylacetoacetate (FAA) hydrolase
APORC_RS08070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APORC_RS08085	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APORC_RS08095	COG0741	lytic transglycosylase activity
APORC_RS08095	COG1196	nuclear chromosome segregation
APORC_RS08095	COG0739	heme binding
APORC_RS08115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APORC_RS08120	COG0085	RNA polymerase activity
APORC_RS08125	COG0222	ribosome binding
APORC_RS08130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APORC_RS08135	COG0081	regulation of translation
APORC_RS08140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APORC_RS08145	COG0250	Participates in transcription elongation, termination and antitermination
APORC_RS08160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APORC_RS08165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APORC_RS08190	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APORC_RS08195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APORC_RS08200	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APORC_RS08205	COG0444	Belongs to the ABC transporter superfamily
APORC_RS08210	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APORC_RS08250	COG3258	Cytochrome c
APORC_RS08275	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APORC_RS08280	COG0475	glutathione-regulated potassium exporter activity
APORC_RS08280	COG0569	domain protein
APORC_RS08285	COG0210	DNA helicase
APORC_RS08295	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APORC_RS08300	COG2996	Protein conserved in bacteria
APORC_RS08305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APORC_RS08310	COG1121	(ABC) transporter
APORC_RS08315	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APORC_RS08320	COG0840	transmembrane signaling receptor activity
APORC_RS08325	COG1355	regulation of microtubule-based process
APORC_RS08335	COG1648	precorrin-2 dehydrogenase activity
APORC_RS08335	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APORC_RS08345	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APORC_RS08350	COG3177	Filamentation induced by cAMP protein fic
APORC_RS08360	COG0459	protein refolding
APORC_RS08375	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APORC_RS08380	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
APORC_RS08390	COG0835	chemotaxis
APORC_RS08395	COG1570	exodeoxyribonuclease VII activity
APORC_RS08400	COG2226	methyltransferase
APORC_RS08415	COG1692	metallophosphoesterase
APORC_RS08420	COG5002	protein histidine kinase activity
APORC_RS08435	COG0840	transmembrane signaling receptor activity
APORC_RS08440	COG2081	HI0933 family
APORC_RS08445	COG0642	Histidine kinase
APORC_RS08450	COG0745	RESPONSE REGULATOR receiver
APORC_RS08505	COG0546	phosphoglycolate phosphatase activity
APORC_RS08550	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APORC_RS08575	COG3328	transposase activity
APORC_RS08590	COG0285	dihydrofolate synthase activity
APORC_RS08600	COG0495	leucyl-tRNA aminoacylation
APORC_RS08610	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
APORC_RS08615	COG1360	Flagellar Motor Protein
APORC_RS08625	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APORC_RS08630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APORC_RS08635	COG1862	Preprotein translocase
APORC_RS08640	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APORC_RS08645	COG4771	TonB-dependent receptor
APORC_RS08650	COG0617	tRNA 3'-terminal CCA addition
APORC_RS08655	COG0668	transmembrane transport
APORC_RS08660	COG0442	prolyl-tRNA aminoacylation
APORC_RS08665	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
APORC_RS08670	COG0142	geranyltranstransferase activity
APORC_RS08680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APORC_RS08685	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APORC_RS08695	COG0811	peptide transport
APORC_RS08705	COG0628	permease
APORC_RS08710	COG0191	fructose-bisphosphate aldolase activity
APORC_RS08715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APORC_RS08720	COG0745	RESPONSE REGULATOR receiver
APORC_RS08725	COG0642	Histidine kinase
APORC_RS08735	COG2404	hydrolase activity, acting on ester bonds
APORC_RS08740	COG1959	2 iron, 2 sulfur cluster binding
APORC_RS08745	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APORC_RS08750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APORC_RS08755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APORC_RS08770	COG0243	molybdopterin cofactor binding
APORC_RS08775	COG0437	4 iron, 4 sulfur cluster binding
APORC_RS08780	COG0348	domain, Protein
APORC_RS08785	COG3043	anaerobic respiration
APORC_RS08805	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APORC_RS08815	COG3328	transposase activity
APORC_RS08820	COG3328	transposase activity
APORC_RS08835	COG2801	Transposase and inactivated derivatives
APORC_RS08855	COG1971	Probably functions as a manganese efflux pump
APORC_RS08860	COG3766	membrane
APORC_RS08870	COG0745	RESPONSE REGULATOR receiver
APORC_RS08875	COG2205	protein histidine kinase activity
APORC_RS08880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APORC_RS08890	COG2824	Alkylphosphonate utilization operon protein PhnA
APORC_RS08900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APORC_RS08905	COG0540	Belongs to the ATCase OTCase family
APORC_RS08915	COG1335	isochorismatase
APORC_RS08920	COG0181	hydroxymethylbilane synthase activity
APORC_RS08930	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APORC_RS08935	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
APORC_RS08940	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APORC_RS08945	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APORC_RS08950	COG0450	alkyl hydroperoxide reductase
APORC_RS08960	COG0105	UTP biosynthetic process
APORC_RS08970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APORC_RS08975	COG0416	fatty acid biosynthetic process
APORC_RS08980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APORC_RS09000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APORC_RS09005	COG1053	succinate dehydrogenase
APORC_RS09015	COG1007	ATP synthesis coupled electron transport
APORC_RS09025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APORC_RS09030	COG0713	ATP synthesis coupled electron transport
APORC_RS09035	COG0839	Belongs to the complex I subunit 6 family
APORC_RS09040	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APORC_RS09045	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
APORC_RS09050	COG1034	ATP synthesis coupled electron transport
APORC_RS09055	COG0372	Belongs to the citrate synthase family
APORC_RS09065	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
APORC_RS09070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APORC_RS09070	COG0649	NAD binding
APORC_RS09075	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APORC_RS09080	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APORC_RS09085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
APORC_RS09090	COG3610	response to peptide
APORC_RS09095	COG2966	Psort location CytoplasmicMembrane, score
APORC_RS09105	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
APORC_RS09110	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APORC_RS09120	COG0840	transmembrane signaling receptor activity
APORC_RS09125	COG3706	GGDEF domain
APORC_RS09145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APORC_RS09155	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
APORC_RS09165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APORC_RS09170	COG2828	Protein conserved in bacteria
APORC_RS09180	COG0469	pyruvate kinase activity
APORC_RS09190	COG0792	nuclease activity
APORC_RS09195	COG0156	8-amino-7-oxononanoate synthase activity
APORC_RS09200	COG0288	reversible hydration of carbon dioxide
APORC_RS09210	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
APORC_RS09220	COG2121	Domain of unknown function (DUF374)
APORC_RS09225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APORC_RS09235	COG0195	Participates in both transcription termination and antitermination
APORC_RS09240	COG0215	cysteine-tRNA ligase activity
APORC_RS09250	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APORC_RS09270	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APORC_RS09305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APORC_RS09340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APORC_RS09360	COG0582	viral genome integration into host DNA
APORC_RS09365	COG0629	single-stranded DNA binding
APORC_RS09370	COG0360	Binds together with S18 to 16S ribosomal RNA
APORC_RS09380	COG0557	exoribonuclease II activity
APORC_RS09385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APORC_RS09400	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APORC_RS09405	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APORC_RS09410	COG0492	ferredoxin-NADP+ reductase activity
APORC_RS09415	COG3118	belongs to the thioredoxin family
APORC_RS09420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APORC_RS09435	COG0642	Histidine kinase
APORC_RS09440	COG0745	RESPONSE REGULATOR receiver
APORC_RS09445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APORC_RS09450	COG0129	dihydroxy-acid dehydratase activity
APORC_RS09470	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APORC_RS09475	COG0585	pseudouridine synthase activity
APORC_RS09490	COG0793	Belongs to the peptidase S41A family
APORC_RS09500	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APORC_RS09505	COG0047	phosphoribosylformylglycinamidine synthase activity
APORC_RS09515	COG0204	Acyl-transferase
APORC_RS09520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APORC_RS09525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APORC_RS09530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APORC_RS09535	COG0018	arginyl-trna synthetase
APORC_RS09545	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APORC_RS09555	COG0126	phosphoglycerate kinase activity
APORC_RS09560	COG0149	triose-phosphate isomerase activity
APORC_RS09565	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APORC_RS09570	COG0019	diaminopimelate decarboxylase activity
APORC_RS09575	COG0077	Prephenate dehydratase
APORC_RS09575	COG1605	Chorismate mutase
APORC_RS09580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APORC_RS09585	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APORC_RS09595	COG0424	maF-like protein
APORC_RS09605	COG2095	MarC family integral membrane protein
APORC_RS09635	COG0189	ligase activity
APORC_RS09650	COG2199	diguanylate cyclase activity
APORC_RS09650	COG3287	FIST C domain
APORC_RS09650	COG2200	EAL domain
APORC_RS09670	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
APORC_RS09675	COG0443	Heat shock 70 kDa protein
APORC_RS09680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APORC_RS09685	COG1420	regulation of RNA biosynthetic process
APORC_RS09705	COG0310	cobalt ion transport
APORC_RS09715	COG0375	protein maturation
APORC_RS09720	COG0309	Hydrogenase expression formation protein (HypE)
APORC_RS09740	COG0298	carbon dioxide binding
APORC_RS09745	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APORC_RS09755	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
APORC_RS09760	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
APORC_RS09765	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
APORC_RS09770	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
APORC_RS09775	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
APORC_RS09780	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
APORC_RS09785	COG0101	tRNA pseudouridine synthase activity
APORC_RS09800	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APORC_RS09805	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APORC_RS09810	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APORC_RS09820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APORC_RS09825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APORC_RS09835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APORC_RS09855	COG2089	acid synthase
APORC_RS09860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APORC_RS09870	COG1083	cytidylyl-transferase
APORC_RS09875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APORC_RS09880	COG1086	Polysaccharide biosynthesis protein
APORC_RS09890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APORC_RS09895	COG0733	neurotransmitter:sodium symporter activity
APORC_RS09900	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
APORC_RS09910	COG0659	secondary active sulfate transmembrane transporter activity
APORC_RS09920	COG1222	aaa ATPase
APORC_RS09930	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
APORC_RS09935	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APORC_RS09955	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APORC_RS09960	COG0148	phosphopyruvate hydratase activity
APORC_RS09975	COG0445	tRNA wobble uridine modification
APORC_RS09985	COG2239	Acts as a magnesium transporter
APORC_RS10000	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APORC_RS10005	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APORC_RS10010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APORC_RS10015	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APORC_RS10020	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APORC_RS10055	COG0670	Belongs to the BI1 family
APORC_RS10065	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APORC_RS10070	COG0233	cytoplasmic translational termination
APORC_RS10075	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APORC_RS10100	COG3022	response to hydroperoxide
APORC_RS10105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
APORC_RS10130	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APORC_RS10145	COG0546	phosphoglycolate phosphatase activity
APORC_RS10150	COG0243	molybdopterin cofactor binding
APORC_RS10160	COG0783	Belongs to the Dps family
APORC_RS10165	COG2814	Major facilitator Superfamily
APORC_RS10175	COG3706	GGDEF domain
APORC_RS10185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APORC_RS10195	COG0840	transmembrane signaling receptor activity
APORC_RS10200	COG2081	HI0933 family
APORC_RS10210	COG1959	2 iron, 2 sulfur cluster binding
APORC_RS10225	COG0175	sulfate reduction
APORC_RS10230	COG0175	sulfate reduction
APORC_RS10235	COG2895	sulfate adenylyltransferase (ATP) activity
APORC_RS10245	COG0133	tryptophan synthase activity
APORC_RS10255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APORC_RS10265	COG1408	metallophosphoesterase
APORC_RS10270	COG1999	signal sequence binding
APORC_RS10285	COG3287	FIST C domain
APORC_RS10285	COG2200	EAL domain
APORC_RS10285	COG2199	diguanylate cyclase activity
APORC_RS10295	COG1217	gtp-binding protein TYPA
APORC_RS10300	COG2391	methyltransferase activity
APORC_RS10305	COG0425	Belongs to the sulfur carrier protein TusA family
APORC_RS10320	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
APORC_RS10325	COG2860	membrane
APORC_RS10350	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group