locus-tag	class	description
EI285_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EI285_RS00010	COG0592	DNA-directed DNA polymerase activity
EI285_RS00015	COG0187	DNA topoisomerase II activity
EI285_RS00020	COG0492	ferredoxin-NADP+ reductase activity
EI285_RS00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EI285_RS00050	COG0500	methyltransferase
EI285_RS00055	COG3842	ATPase activity
EI285_RS00095	COG0564	pseudouridine synthase activity
EI285_RS00100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EI285_RS00105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EI285_RS00110	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EI285_RS00120	COG0052	Belongs to the universal ribosomal protein uS2 family
EI285_RS00125	COG0604	alcohol dehydrogenase
EI285_RS00130	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EI285_RS00135	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EI285_RS00145	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EI285_RS00145	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EI285_RS00150	COG0511	ligase activity, forming carbon-carbon bonds
EI285_RS00155	COG0439	Biotin carboxylase
EI285_RS00160	COG0513	Belongs to the DEAD box helicase family
EI285_RS00165	COG0306	phosphate transporter
EI285_RS00175	COG0367	asparagine synthase
EI285_RS00185	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EI285_RS00190	COG1981	membrane
EI285_RS00195	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EI285_RS00195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EI285_RS00200	COG1187	pseudouridine synthase activity
EI285_RS00205	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EI285_RS00205	COG0517	IMP dehydrogenase activity
EI285_RS00210	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EI285_RS00215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EI285_RS00220	COG0107	imidazoleglycerol-phosphate synthase activity
EI285_RS00235	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EI285_RS00240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EI285_RS00245	COG0724	RNA recognition motif
EI285_RS00255	COG0460	homoserine dehydrogenase
EI285_RS00260	COG0436	Aminotransferase
EI285_RS00270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EI285_RS00275	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EI285_RS00280	COG0254	rRNA binding
EI285_RS00285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EI285_RS00295	COG0109	protoheme IX farnesyltransferase activity
EI285_RS00315	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EI285_RS00320	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EI285_RS00325	COG0573	inorganic phosphate transmembrane transporter activity
EI285_RS00330	COG0581	inorganic phosphate transmembrane transporter activity
EI285_RS00335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EI285_RS00350	COG0745	RESPONSE REGULATOR receiver
EI285_RS00355	COG2205	protein histidine kinase activity
EI285_RS00360	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EI285_RS00365	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EI285_RS00370	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EI285_RS00395	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EI285_RS00400	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EI285_RS00410	COG0352	thiamine-phosphate diphosphorylase activity
EI285_RS00410	COG0351	phosphomethylpyrimidine kinase
EI285_RS00420	COG0546	phosphoglycolate phosphatase activity
EI285_RS00435	COG1854	S-ribosylhomocysteine lyase activity
EI285_RS00455	COG1410	methionine synthase
EI285_RS00455	COG0646	methionine synthase
EI285_RS00480	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EI285_RS00480	COG0140	phosphoribosyl-ATP diphosphatase activity
EI285_RS00495	COG0456	acetyltransferase
EI285_RS00500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EI285_RS00505	COG1917	Cupin 2, conserved barrel domain protein
EI285_RS00520	COG0489	protein tyrosine kinase activity
EI285_RS00530	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EI285_RS00530	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EI285_RS00540	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EI285_RS00550	COG0505	Belongs to the CarA family
EI285_RS00560	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EI285_RS00565	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EI285_RS00570	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EI285_RS00595	COG4895	conserved protein (DUF2196)
EI285_RS00600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EI285_RS00605	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EI285_RS00610	COG0237	dephospho-CoA kinase activity
EI285_RS00620	COG0504	CTP synthase activity
EI285_RS00625	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EI285_RS00625	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EI285_RS00640	COG0693	protein deglycase activity
EI285_RS00645	COG0587	DNA-directed DNA polymerase activity
EI285_RS00650	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EI285_RS00665	COG3040	lipid binding
EI285_RS00685	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EI285_RS00695	COG2200	EAL domain
EI285_RS00700	COG3279	Response regulator of the LytR AlgR family
EI285_RS00705	COG3275	phosphorelay sensor kinase activity
EI285_RS00710	COG1233	COG1233 Phytoene dehydrogenase and related
EI285_RS00715	COG0415	Belongs to the DNA photolyase family
EI285_RS00730	COG0315	cyclic pyranopterin monophosphate synthase activity
EI285_RS00735	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EI285_RS00740	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EI285_RS00745	COG0268	Binds directly to 16S ribosomal RNA
EI285_RS00750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EI285_RS00755	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EI285_RS00760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EI285_RS00765	COG0746	molybdenum cofactor guanylyltransferase activity
EI285_RS00780	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EI285_RS00785	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EI285_RS00790	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EI285_RS00795	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EI285_RS00815	COG0575	Belongs to the CDS family
EI285_RS00820	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EI285_RS00835	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EI285_RS00845	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EI285_RS00845	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EI285_RS00905	COG0840	transmembrane signaling receptor activity
EI285_RS00910	COG4191	Histidine kinase
EI285_RS00915	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EI285_RS00920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EI285_RS00940	COG1742	UPF0060 membrane protein
EI285_RS00970	COG0004	ammonium transporteR
EI285_RS00975	COG0347	Belongs to the P(II) protein family
EI285_RS00985	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EI285_RS00990	COG1706	bacterial-type flagellum-dependent cell motility
EI285_RS01000	COG1987	bacterial-type flagellum assembly
EI285_RS01025	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EI285_RS01055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EI285_RS01065	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EI285_RS01070	COG0601	transmembrane transport
EI285_RS01075	COG0736	holo-[acyl-carrier-protein] synthase activity
EI285_RS01090	COG0786	glutamate:sodium symporter activity
EI285_RS01095	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EI285_RS01105	COG0560	Phosphoserine phosphatase
EI285_RS01110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EI285_RS01115	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EI285_RS01120	COG3248	Nucleoside-binding outer membrane protein
EI285_RS01125	COG1393	Belongs to the ArsC family
EI285_RS01130	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EI285_RS01135	COG0343	queuine tRNA-ribosyltransferase activity
EI285_RS01170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EI285_RS01175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EI285_RS01180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EI285_RS01185	COG3278	Belongs to the heme-copper respiratory oxidase family
EI285_RS01240	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EI285_RS01255	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EI285_RS01265	COG0157	Belongs to the NadC ModD family
EI285_RS01280	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EI285_RS01290	COG0083	homoserine kinase activity
EI285_RS01300	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EI285_RS01305	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EI285_RS01310	COG0779	Required for maturation of 30S ribosomal subunits
EI285_RS01315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EI285_RS01315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EI285_RS01320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EI285_RS01325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EI285_RS01330	COG1185	polyribonucleotide nucleotidyltransferase activity
EI285_RS01330	COG0539	negative regulation of cytoplasmic translation
EI285_RS01335	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EI285_RS01340	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EI285_RS01345	COG0072	phenylalanine-tRNA ligase activity
EI285_RS01345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EI285_RS01350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EI285_RS01355	COG0537	adenosine 5'-monophosphoramidase activity
EI285_RS01365	COG0825	malonyl-CoA metabolic process
EI285_RS01370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EI285_RS01375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EI285_RS01385	COG0602	queuosine metabolic process
EI285_RS01395	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EI285_RS01405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EI285_RS01420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EI285_RS01425	COG0723	plastoquinol--plastocyanin reductase activity
EI285_RS01430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EI285_RS01435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EI285_RS01440	COG0210	DNA helicase
EI285_RS01445	COG0356	it plays a direct role in the translocation of protons across the membrane
EI285_RS01450	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EI285_RS01455	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EI285_RS01465	COG0336	Belongs to the RNA methyltransferase TrmD family
EI285_RS01470	COG0335	large ribosomal subunit rRNA binding
EI285_RS01475	COG0586	Pfam SNARE associated Golgi protein
EI285_RS01480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EI285_RS01495	COG0251	oxidation-reduction process
EI285_RS01510	COG2183	response to ionizing radiation
EI285_RS01535	COG0540	Belongs to the ATCase OTCase family
EI285_RS01540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EI285_RS01545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EI285_RS01550	COG2824	Alkylphosphonate utilization operon protein PhnA
EI285_RS01560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EI285_RS01565	COG2205	protein histidine kinase activity
EI285_RS01570	COG0745	RESPONSE REGULATOR receiver
EI285_RS01575	COG0628	permease
EI285_RS01590	COG0659	secondary active sulfate transmembrane transporter activity
EI285_RS01605	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EI285_RS01625	COG3043	anaerobic respiration
EI285_RS01630	COG0348	domain, Protein
EI285_RS01635	COG0437	4 iron, 4 sulfur cluster binding
EI285_RS01640	COG0243	molybdopterin cofactor binding
EI285_RS01655	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EI285_RS01660	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EI285_RS01670	COG2404	hydrolase activity, acting on ester bonds
EI285_RS01680	COG0642	Histidine kinase
EI285_RS01685	COG0745	RESPONSE REGULATOR receiver
EI285_RS01690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EI285_RS01695	COG0191	fructose-bisphosphate aldolase activity
EI285_RS01700	COG0039	L-malate dehydrogenase activity
EI285_RS01710	COG0848	biopolymer transport protein
EI285_RS01715	COG0811	peptide transport
EI285_RS01730	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EI285_RS01740	COG0142	geranyltranstransferase activity
EI285_RS01745	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EI285_RS01750	COG0442	prolyl-tRNA aminoacylation
EI285_RS01755	COG0668	transmembrane transport
EI285_RS01760	COG0617	tRNA 3'-terminal CCA addition
EI285_RS01785	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EI285_RS01790	COG1862	Preprotein translocase
EI285_RS01795	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EI285_RS01800	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EI285_RS01815	COG1360	Flagellar Motor Protein
EI285_RS01820	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EI285_RS01830	COG0495	leucyl-tRNA aminoacylation
EI285_RS01840	COG0285	dihydrofolate synthase activity
EI285_RS01870	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EI285_RS01885	COG5001	Diguanylate cyclase
EI285_RS01885	COG4251	negative regulation of phosphorylation
EI285_RS01885	COG3706	GGDEF domain
EI285_RS01885	COG2203	Gaf domain
EI285_RS01895	COG0745	RESPONSE REGULATOR receiver
EI285_RS01900	COG0642	Histidine kinase
EI285_RS01905	COG2081	HI0933 family
EI285_RS01910	COG0840	transmembrane signaling receptor activity
EI285_RS01925	COG5002	protein histidine kinase activity
EI285_RS01930	COG1692	metallophosphoesterase
EI285_RS01950	COG1570	exodeoxyribonuclease VII activity
EI285_RS01955	COG0835	chemotaxis
EI285_RS01960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EI285_RS01965	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EI285_RS01970	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EI285_RS01985	COG0459	protein refolding
EI285_RS01995	COG0745	RESPONSE REGULATOR receiver
EI285_RS02000	COG5002	protein histidine kinase activity
EI285_RS02010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EI285_RS02020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EI285_RS02025	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EI285_RS02035	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EI285_RS02045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EI285_RS02050	COG2264	protein methyltransferase activity
EI285_RS02055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EI285_RS02060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EI285_RS02075	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EI285_RS02085	COG2095	MarC family integral membrane protein
EI285_RS02105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EI285_RS02105	COG1648	precorrin-2 dehydrogenase activity
EI285_RS02115	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EI285_RS02115	COG1648	precorrin-2 dehydrogenase activity
EI285_RS02120	COG2078	PFAM AMMECR1 domain protein
EI285_RS02125	COG1355	regulation of microtubule-based process
EI285_RS02130	COG0840	transmembrane signaling receptor activity
EI285_RS02135	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EI285_RS02140	COG1121	(ABC) transporter
EI285_RS02145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EI285_RS02150	COG2996	Protein conserved in bacteria
EI285_RS02155	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EI285_RS02165	COG0210	DNA helicase
EI285_RS02170	COG0569	domain protein
EI285_RS02170	COG0475	glutathione-regulated potassium exporter activity
EI285_RS02175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EI285_RS02200	COG3258	Cytochrome c
EI285_RS02235	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EI285_RS02240	COG4608	Belongs to the ABC transporter superfamily
EI285_RS02245	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EI285_RS02250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EI285_RS02280	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EI285_RS02285	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EI285_RS02300	COG0250	Participates in transcription elongation, termination and antitermination
EI285_RS02305	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EI285_RS02310	COG0081	regulation of translation
EI285_RS02315	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EI285_RS02320	COG0222	ribosome binding
EI285_RS02325	COG0085	RNA polymerase activity
EI285_RS02330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EI285_RS02350	COG0739	heme binding
EI285_RS02350	COG0741	lytic transglycosylase activity
EI285_RS02350	COG1196	nuclear chromosome segregation
EI285_RS02360	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EI285_RS02375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EI285_RS02390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EI285_RS02400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EI285_RS02415	COG2326	polyphosphate kinase activity
EI285_RS02420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EI285_RS02425	COG0571	ribonuclease III activity
EI285_RS02435	COG0358	DNA primase activity
EI285_RS02440	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EI285_RS02445	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EI285_RS02450	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EI285_RS02455	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EI285_RS02460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EI285_RS02470	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EI285_RS02470	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EI285_RS02475	COG1192	Involved in chromosome partitioning
EI285_RS02480	COG1475	DNA binding
EI285_RS02490	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EI285_RS02495	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EI285_RS02500	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EI285_RS02505	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EI285_RS02510	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EI285_RS02515	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EI285_RS02520	COG0811	peptide transport
EI285_RS02525	COG0848	biopolymer transport protein
EI285_RS02535	COG0823	Involved in the tonB-independent uptake of proteins
EI285_RS02550	COG1047	Peptidyl-prolyl cis-trans
EI285_RS02555	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EI285_RS02560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EI285_RS02565	COG1027	Aspartate ammonia-lyase
EI285_RS02575	COG1227	inorganic diphosphatase activity
EI285_RS02580	COG0668	transmembrane transport
EI285_RS02585	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EI285_RS02595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EI285_RS02600	COG0010	Belongs to the arginase family
EI285_RS02605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EI285_RS02610	COG1278	Cold shock
EI285_RS02625	COG4335	DNA alkylation repair
EI285_RS02645	COG0753	catalase activity
EI285_RS02670	COG4753	response regulator
EI285_RS02670	COG2207	Transcriptional regulator
EI285_RS02675	COG4191	Histidine kinase
EI285_RS02680	COG0348	domain, Protein
EI285_RS02685	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EI285_RS02695	COG0840	transmembrane signaling receptor activity
EI285_RS02700	COG0840	transmembrane signaling receptor activity
EI285_RS02705	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EI285_RS02710	COG0750	zinc metalloprotease
EI285_RS02715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EI285_RS02720	COG1028	Short-chain dehydrogenase reductase Sdr
EI285_RS02725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EI285_RS02735	COG0167	dihydroorotate dehydrogenase activity
EI285_RS02740	COG1132	(ABC) transporter
EI285_RS02745	COG0728	peptidoglycan biosynthetic process
EI285_RS02760	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EI285_RS02770	COG0789	Transcriptional regulator
EI285_RS02775	COG0484	heat shock protein binding
EI285_RS02795	COG0326	Molecular chaperone. Has ATPase activity
EI285_RS02805	COG0513	Belongs to the DEAD box helicase family
EI285_RS02820	COG0259	pyridoxamine-phosphate oxidase activity
EI285_RS02825	COG3287	FIST C domain
EI285_RS02825	COG2200	EAL domain
EI285_RS02825	COG2199	diguanylate cyclase activity
EI285_RS02890	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EI285_RS02895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EI285_RS02895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EI285_RS02910	COG1090	epimerase
EI285_RS02915	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EI285_RS02950	COG0730	response to heat
EI285_RS02955	COG1045	serine acetyltransferase
EI285_RS02960	COG1166	arginine decarboxylase activity
EI285_RS02965	COG0124	histidyl-tRNA synthetase
EI285_RS02970	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EI285_RS02985	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EI285_RS02990	COG0163	prenyltransferase activity
EI285_RS03000	COG0359	binds to the 23S rRNA
EI285_RS03005	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EI285_RS03010	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EI285_RS03020	COG0084	hydrolase, TatD family'
EI285_RS03025	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EI285_RS03030	COG0131	Imidazoleglycerol-phosphate dehydratase
EI285_RS03035	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EI285_RS03050	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EI285_RS03055	COG0456	acetyltransferase
EI285_RS03060	COG0051	transcription antitermination factor activity, RNA binding
EI285_RS03065	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EI285_RS03070	COG0088	Forms part of the polypeptide exit tunnel
EI285_RS03075	COG0089	rRNA binding
EI285_RS03080	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EI285_RS03085	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EI285_RS03090	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EI285_RS03095	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EI285_RS03100	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EI285_RS03105	COG0255	Belongs to the universal ribosomal protein uL29 family
EI285_RS03110	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EI285_RS03115	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EI285_RS03120	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EI285_RS03125	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EI285_RS03130	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EI285_RS03135	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EI285_RS03140	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EI285_RS03145	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EI285_RS03150	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EI285_RS03155	COG0200	Binds to the 23S rRNA
EI285_RS03160	COG0201	protein transport
EI285_RS03165	COG0024	Methionine aminopeptidase
EI285_RS03170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EI285_RS03175	COG1573	uracil-dna glycosylase
EI285_RS03185	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EI285_RS03190	COG1032	radical SAM domain protein
EI285_RS03195	COG0563	adenylate kinase activity
EI285_RS03200	COG0563	adenylate kinase activity
EI285_RS03215	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EI285_RS03220	COG0840	transmembrane signaling receptor activity
EI285_RS03225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EI285_RS03230	COG0322	excinuclease ABC activity
EI285_RS03245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EI285_RS03255	COG3437	response regulator, receiver
EI285_RS03255	COG0784	Response regulator, receiver
EI285_RS03260	COG1338	Plays a role in the flagellum-specific transport system
EI285_RS03265	COG0768	penicillin binding
EI285_RS03285	COG2884	Cell division ATP-binding protein ftsE
EI285_RS03290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EI285_RS03300	COG0564	pseudouridine synthase activity
EI285_RS03305	COG0772	Belongs to the SEDS family
EI285_RS03315	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EI285_RS03320	COG3123	guanosine phosphorylase activity
EI285_RS03335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EI285_RS03340	COG0066	3-isopropylmalate dehydratase activity
EI285_RS03345	COG0473	3-isopropylmalate dehydrogenase activity
EI285_RS03360	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EI285_RS03365	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EI285_RS03370	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EI285_RS03375	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EI285_RS03380	COG0202	RNA polymerase activity
EI285_RS03385	COG0203	ribosomal protein L17
EI285_RS03390	COG0154	amidase activity
EI285_RS03395	COG0516	GMP reductase activity
EI285_RS03395	COG0517	IMP dehydrogenase activity
EI285_RS03410	COG0484	heat shock protein binding
EI285_RS03415	COG0484	heat shock protein binding
EI285_RS03420	COG1472	Belongs to the glycosyl hydrolase 3 family
EI285_RS03425	COG0513	Belongs to the DEAD box helicase family
EI285_RS03430	COG2217	Heavy metal translocating P-type atpase
EI285_RS03440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EI285_RS03445	COG0508	dehydrogenase complex catalyzes the overall conversion of
EI285_RS03450	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EI285_RS03455	COG0095	Lipoate-protein ligase
EI285_RS03460	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EI285_RS03465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EI285_RS03470	COG0840	transmembrane signaling receptor activity
EI285_RS03475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EI285_RS03480	COG1944	ATP diphosphatase activity
EI285_RS03485	COG2258	MOSC domain
EI285_RS03490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EI285_RS03490	COG2169	Transcriptional regulator
EI285_RS03495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EI285_RS03510	COG4536	flavin adenine dinucleotide binding
EI285_RS03515	COG0628	permease
EI285_RS03535	COG4974	Belongs to the 'phage' integrase family
EI285_RS03575	COG0849	cell division
EI285_RS03615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EI285_RS03630	COG0776	regulation of translation
EI285_RS03650	COG3328	transposase activity
EI285_RS03785	COG1401	restriction endodeoxyribonuclease activity
EI285_RS03805	COG2234	aminopeptidase activity
EI285_RS03825	COG1401	restriction endodeoxyribonuclease activity
EI285_RS03845	COG2234	aminopeptidase activity
EI285_RS03865	COG1401	restriction endodeoxyribonuclease activity
EI285_RS03915	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EI285_RS03960	COG0284	orotidine-5'-phosphate decarboxylase activity
EI285_RS03965	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EI285_RS03970	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EI285_RS03995	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EI285_RS04000	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EI285_RS04010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EI285_RS04020	COG1295	ribonuclease BN
EI285_RS04025	COG0277	FAD linked oxidase domain protein
EI285_RS04035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EI285_RS04040	COG2226	methyltransferase
EI285_RS04095	COG1739	Uncharacterized protein family UPF0029
EI285_RS04115	COG0301	tRNA thio-modification
EI285_RS04115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EI285_RS04125	COG2814	Major facilitator Superfamily
EI285_RS04150	COG2081	HI0933 family
EI285_RS04180	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EI285_RS04185	COG2171	N-acyltransferase activity
EI285_RS04190	COG0488	(ABC) transporter
EI285_RS04265	COG1137	ATPase activity
EI285_RS04275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EI285_RS04280	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EI285_RS04285	COG0137	argininosuccinate synthase activity
EI285_RS04300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EI285_RS04310	COG0776	regulation of translation
EI285_RS04315	COG0708	Exodeoxyribonuclease III
EI285_RS04355	COG2204	response regulator
EI285_RS04365	COG0166	Belongs to the GPI family
EI285_RS04405	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EI285_RS04435	COG1858	cytochrome C peroxidase
EI285_RS04445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EI285_RS04455	COG1921	L-seryl-tRNASec selenium transferase activity
EI285_RS04480	COG0450	alkyl hydroperoxide reductase
EI285_RS04485	COG0840	transmembrane signaling receptor activity
EI285_RS04490	COG0840	transmembrane signaling receptor activity
EI285_RS04495	COG0709	Synthesizes selenophosphate from selenide and ATP
EI285_RS04500	COG1305	Transglutaminase-like
EI285_RS04520	COG2204	response regulator
EI285_RS04560	COG0437	4 iron, 4 sulfur cluster binding
EI285_RS04570	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EI285_RS04590	COG0303	'Molybdopterin
EI285_RS04595	COG2998	abc-type tungstate transport system, permease component
EI285_RS04600	COG4662	Binding-protein-dependent transport system inner membrane component
EI285_RS04615	COG0446	pyridine nucleotide-disulphide oxidoreductase
EI285_RS04630	COG1132	(ABC) transporter
EI285_RS04640	COG0596	Alpha beta hydrolase
EI285_RS04675	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EI285_RS04675	COG0519	Catalyzes the synthesis of GMP from XMP
EI285_RS04680	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EI285_RS04695	COG0436	Aminotransferase
EI285_RS04710	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EI285_RS04715	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EI285_RS04715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EI285_RS04740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EI285_RS04745	COG1611	Belongs to the LOG family
EI285_RS04765	COG0217	transcriptional regulatory protein
EI285_RS04785	COG0428	transporter
EI285_RS04790	COG1049	propionate catabolic process, 2-methylcitrate cycle
EI285_RS04795	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EI285_RS04795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EI285_RS04840	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EI285_RS04845	COG0511	ligase activity, forming carbon-carbon bonds
EI285_RS04845	COG5016	pyruvate
EI285_RS04865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EI285_RS04865	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EI285_RS04875	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EI285_RS04900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EI285_RS04905	COG0612	Peptidase, M16
EI285_RS04910	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EI285_RS04915	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EI285_RS04920	COG0287	Prephenate dehydrogenase
EI285_RS04925	COG0386	Belongs to the glutathione peroxidase family
EI285_RS04955	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EI285_RS04965	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EI285_RS04980	COG0527	aspartate kinase activity
EI285_RS04985	COG0494	nUDIX hydrolase
EI285_RS04990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EI285_RS04995	COG2890	protein-(glutamine-N5) methyltransferase activity
EI285_RS05000	COG0339	signal peptide processing
EI285_RS05015	COG0582	viral genome integration into host DNA
EI285_RS05020	COG2201	protein-glutamate methylesterase activity
EI285_RS05035	COG0643	Histidine kinase
EI285_RS05035	COG2198	Histidine kinase
EI285_RS05040	COG0745	RESPONSE REGULATOR receiver
EI285_RS05045	COG1185	polyribonucleotide nucleotidyltransferase activity
EI285_RS05075	COG1160	GTP binding
EI285_RS05080	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EI285_RS05085	COG1028	Short-chain dehydrogenase reductase Sdr
EI285_RS05090	COG1196	nuclear chromosome segregation
EI285_RS05090	COG1674	ftsk spoiiie
EI285_RS05095	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EI285_RS05100	COG0440	acetolactate synthase activity
EI285_RS05105	COG0028	Belongs to the TPP enzyme family
EI285_RS05140	COG0037	tRNA processing
EI285_RS05160	COG0501	Belongs to the peptidase M48B family
EI285_RS05165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EI285_RS05170	COG0824	Thioesterase
EI285_RS05180	COG1663	tetraacyldisaccharide 4'-kinase activity
EI285_RS05185	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EI285_RS05190	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EI285_RS05210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EI285_RS05215	COG0805	protein transport
EI285_RS05220	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EI285_RS05265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EI285_RS05280	COG0840	transmembrane signaling receptor activity
EI285_RS05300	COG0357	Ribosomal RNA small subunit methyltransferase G
EI285_RS05305	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EI285_RS05310	COG0113	porphobilinogen synthase activity
EI285_RS05325	COG1086	Polysaccharide biosynthesis protein
EI285_RS05335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EI285_RS05340	COG2161	toxin-antitoxin pair type II binding
EI285_RS05390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EI285_RS05400	COG1051	belongs to the nudix hydrolase family
EI285_RS05460	COG0667	Aldo Keto reductase
EI285_RS05485	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EI285_RS05490	COG0484	heat shock protein binding
EI285_RS05500	COG2111	Na H antiporter
EI285_RS05500	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EI285_RS05505	COG1006	Multisubunit Na H antiporter MnhC subunit
EI285_RS05510	COG0651	ATP synthesis coupled electron transport
EI285_RS05515	COG1863	multisubunit Na H antiporter MnhE subunit
EI285_RS05520	COG2212	antiporter activity
EI285_RS05525	COG1320	monovalent cation:proton antiporter activity
EI285_RS05535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EI285_RS05545	COG0500	methyltransferase
EI285_RS05550	COG2195	Cleaves the N-terminal amino acid of tripeptides
EI285_RS05555	COG1333	cytochrome c biogenesis protein
EI285_RS05555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EI285_RS05565	COG0135	phosphoribosylanthranilate isomerase activity
EI285_RS05570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EI285_RS05590	COG1666	GTP binding
EI285_RS05595	COG2363	Small membrane protein
EI285_RS05600	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EI285_RS05605	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EI285_RS05610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EI285_RS05625	COG1119	ATPase activity
EI285_RS05635	COG1253	flavin adenine dinucleotide binding
EI285_RS05640	COG1193	negative regulation of DNA recombination
EI285_RS05645	COG0521	Mo-molybdopterin cofactor biosynthetic process
EI285_RS05655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EI285_RS05660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EI285_RS05670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EI285_RS05680	COG4139	cobalamin transport
EI285_RS05690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EI285_RS05710	COG0546	phosphoglycolate phosphatase activity
EI285_RS05715	COG1187	pseudouridine synthase activity
EI285_RS05720	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EI285_RS05740	COG0328	RNA-DNA hybrid ribonuclease activity
EI285_RS05745	COG0488	(ABC) transporter
EI285_RS05755	COG0739	heme binding
EI285_RS05765	COG0134	indole-3-glycerol-phosphate synthase activity
EI285_RS05775	COG0727	PFAM Uncharacterised protein family (UPF0153)
EI285_RS05780	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EI285_RS05790	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EI285_RS05790	COG0674	pyruvate-flavodoxin oxidoreductase activity
EI285_RS05795	COG1013	pyruvate-flavodoxin oxidoreductase activity
EI285_RS05815	COG0653	protein targeting
EI285_RS05820	COG4591	ABC-type transport system involved in lipoprotein release permease component
EI285_RS05860	COG0275	rRNA processing
EI285_RS05870	COG0776	regulation of translation
EI285_RS05885	COG0300	oxidoreductase activity
EI285_RS05890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EI285_RS05895	COG0742	ribosomal rna small subunit methyltransferase
EI285_RS05900	COG1418	mRNA catabolic process
EI285_RS05915	COG0552	protein localization to endoplasmic reticulum
EI285_RS05930	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EI285_RS05935	COG0861	Integral membrane protein TerC family
EI285_RS05940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EI285_RS05950	COG5002	protein histidine kinase activity
EI285_RS05955	COG0745	RESPONSE REGULATOR receiver
EI285_RS05965	COG1283	sodium-dependent phosphate transmembrane transporter activity
EI285_RS05975	COG1114	Component of the transport system for branched-chain amino acids
EI285_RS05980	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EI285_RS05985	COG0788	formyltetrahydrofolate deformylase activity
EI285_RS05990	COG0280	phosphate acetyltransferase
EI285_RS05990	COG0281	malic enzyme
EI285_RS05995	COG1496	oxidoreductase activity
EI285_RS06000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EI285_RS06005	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EI285_RS06035	COG0740	serine-type endopeptidase activity
EI285_RS06085	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EI285_RS06110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EI285_RS06120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EI285_RS06130	COG2391	methyltransferase activity
EI285_RS06140	COG0849	cell division
EI285_RS06150	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EI285_RS06160	COG0513	Belongs to the DEAD box helicase family
EI285_RS06170	COG0754	glutathionylspermidine amidase activity
EI285_RS06175	COG1607	acyl-coa hydrolase
EI285_RS06180	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EI285_RS06190	COG1136	(ABC) transporter
EI285_RS06190	COG0577	efflux transmembrane transporter activity
EI285_RS06195	COG1136	(ABC) transporter
EI285_RS06195	COG0577	efflux transmembrane transporter activity
EI285_RS06200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EI285_RS06215	COG0848	biopolymer transport protein
EI285_RS06225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EI285_RS06235	COG0133	tryptophan synthase activity
EI285_RS06240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EI285_RS06245	COG1793	dna ligase
EI285_RS06250	COG0626	cystathionine gamma-synthase activity
EI285_RS06265	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
EI285_RS06270	COG0803	Belongs to the bacterial solute-binding protein 9 family
EI285_RS06280	COG0528	UMP kinase activity
EI285_RS06285	COG1758	RNA polymerase activity
EI285_RS06295	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EI285_RS06305	COG0860	N-Acetylmuramoyl-L-alanine amidase
EI285_RS06320	COG0193	aminoacyl-tRNA hydrolase activity
EI285_RS06325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EI285_RS06330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EI285_RS06335	COG0681	Belongs to the peptidase S26 family
EI285_RS06340	COG0698	ribose 5-phosphate isomerase
EI285_RS06355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EI285_RS06360	COG5002	protein histidine kinase activity
EI285_RS06360	COG0784	Response regulator, receiver
EI285_RS06360	COG2198	Histidine kinase
EI285_RS06365	COG4251	negative regulation of phosphorylation
EI285_RS06365	COG5001	Diguanylate cyclase
EI285_RS06365	COG3706	GGDEF domain
EI285_RS06365	COG2203	Gaf domain
EI285_RS06370	COG0556	nucleotide-excision repair
EI285_RS06380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EI285_RS06385	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EI285_RS06390	COG0835	chemotaxis
EI285_RS06390	COG0784	Response regulator, receiver
EI285_RS06395	COG0165	Argininosuccinate lyase
EI285_RS06405	COG2239	Acts as a magnesium transporter
EI285_RS06415	COG0719	Fe-S assembly protein
EI285_RS06420	COG0396	ATPase activity
EI285_RS06425	COG0719	Fe-S assembly protein
EI285_RS06430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EI285_RS06435	COG2166	iron-sulfur cluster assembly
EI285_RS06455	COG4773	Receptor
EI285_RS06460	COG0439	Biotin carboxylase
EI285_RS06480	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EI285_RS06490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EI285_RS06510	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EI285_RS06515	COG2814	Major facilitator Superfamily
EI285_RS06535	COG0525	valine-tRNA ligase activity
EI285_RS06555	COG0174	glutamine synthetase
EI285_RS06565	COG0314	molybdopterin synthase activity
EI285_RS06575	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
EI285_RS06580	COG1968	undecaprenyl-diphosphatase activity
EI285_RS06590	COG0772	Belongs to the SEDS family
EI285_RS06595	COG0768	penicillin binding
EI285_RS06600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EI285_RS06645	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EI285_RS06655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EI285_RS06670	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EI285_RS06680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EI285_RS06690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EI285_RS06700	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EI285_RS06700	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EI285_RS06705	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EI285_RS06715	COG1368	sulfuric ester hydrolase activity
EI285_RS06735	COG0463	Glycosyl transferase, family 2
EI285_RS06740	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EI285_RS06770	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EI285_RS06780	COG0859	PFAM glycosyl transferase family 9
EI285_RS06790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EI285_RS06820	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EI285_RS06830	COG1181	Belongs to the D-alanine--D-alanine ligase family
EI285_RS06835	COG0632	four-way junction helicase activity
EI285_RS06840	COG0840	transmembrane signaling receptor activity
EI285_RS06850	COG0585	pseudouridine synthase activity
EI285_RS06855	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EI285_RS06860	COG3123	guanosine phosphorylase activity
EI285_RS06875	COG1639	'signal transduction protein
EI285_RS06880	COG0012	GTP binding
EI285_RS06885	COG1966	Carbon starvation protein
EI285_RS06915	COG0305	Participates in initiation and elongation during chromosome replication
EI285_RS06920	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EI285_RS06935	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EI285_RS06940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EI285_RS06950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EI285_RS06955	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EI285_RS06960	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EI285_RS06970	COG3706	GGDEF domain
EI285_RS06975	COG0501	Belongs to the peptidase M48B family
EI285_RS06990	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EI285_RS07000	COG0706	membrane insertase activity
EI285_RS07005	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EI285_RS07015	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EI285_RS07020	COG0542	response to heat
EI285_RS07025	COG0488	(ABC) transporter
EI285_RS07035	COG0778	Nitroreductase
EI285_RS07040	COG2249	NAD(P)H dehydrogenase (quinone) activity
EI285_RS07055	COG2855	membrane
EI285_RS07060	COG0583	DNA-binding transcription factor activity
EI285_RS07070	COG2076	Multidrug Resistance protein
EI285_RS07075	COG0642	Histidine kinase
EI285_RS07090	COG3258	Cytochrome c
EI285_RS07135	COG0628	permease
EI285_RS07140	COG2255	four-way junction helicase activity
EI285_RS07145	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EI285_RS07150	COG0159	tryptophan synthase activity
EI285_RS07155	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EI285_RS07160	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EI285_RS07185	COG0598	Magnesium transport protein CorA
EI285_RS07190	COG1459	type II secretion system
EI285_RS07195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EI285_RS07210	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EI285_RS07215	COG0606	chelatase, subunit chli
EI285_RS07220	COG0840	transmembrane signaling receptor activity
EI285_RS07225	COG0840	transmembrane signaling receptor activity
EI285_RS07235	COG0242	peptide deformylase activity
EI285_RS07240	COG0740	serine-type endopeptidase activity
EI285_RS07245	COG0544	peptidyl-prolyl cis-trans isomerase activity
EI285_RS07250	COG2326	polyphosphate kinase activity
EI285_RS07320	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EI285_RS07395	COG4804	nuclease activity
EI285_RS07400	COG1002	Type II restriction enzyme, methylase subunits
EI285_RS07435	COG2204	response regulator
EI285_RS07440	COG0840	transmembrane signaling receptor activity
EI285_RS07465	COG3111	PFAM Bacterial OB fold (BOF) protein
EI285_RS07470	COG0642	Histidine kinase
EI285_RS07475	COG0745	RESPONSE REGULATOR receiver
EI285_RS07600	COG0542	response to heat
EI285_RS07605	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EI285_RS07610	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EI285_RS07625	COG2030	dehydratase
EI285_RS07660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EI285_RS07670	COG0481	GTPase activity
EI285_RS07675	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EI285_RS07685	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EI285_RS07690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EI285_RS07695	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EI285_RS07700	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EI285_RS07720	COG2217	Heavy metal translocating P-type atpase
EI285_RS07725	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EI285_RS07730	COG0194	GDP metabolic process
EI285_RS07740	COG1136	(ABC) transporter
EI285_RS07745	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EI285_RS07750	COG0052	Belongs to the universal ribosomal protein uS2 family
EI285_RS07755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EI285_RS07770	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EI285_RS07775	COG0579	oxidoreductase
EI285_RS07805	COG0642	Histidine kinase
EI285_RS07810	COG0745	RESPONSE REGULATOR receiver
EI285_RS07825	COG2176	DNA-directed DNA polymerase activity
EI285_RS07835	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EI285_RS07855	COG2176	DNA-directed DNA polymerase activity
EI285_RS07865	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EI285_RS07870	COG0280	phosphate acetyltransferase
EI285_RS07880	COG0616	signal peptide processing
EI285_RS07885	COG0402	S-adenosylhomocysteine deaminase activity
EI285_RS07890	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EI285_RS07895	COG0006	proline dipeptidase activity
EI285_RS07900	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EI285_RS07905	COG0482	sulfurtransferase activity
EI285_RS07910	COG0482	sulfurtransferase activity
EI285_RS07915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EI285_RS07925	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EI285_RS07935	COG1157	protein secretion by the type III secretion system
EI285_RS07945	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EI285_RS07975	COG0455	bacterial-type flagellum organization
EI285_RS07980	COG1419	protein localization to endoplasmic reticulum
EI285_RS07995	COG3951	Flagellar rod assembly protein muramidase FlgJ
EI285_RS08040	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EI285_RS08050	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EI285_RS08055	COG1766	The M ring may be actively involved in energy transduction
EI285_RS08060	COG1815	bacterial-type flagellum-dependent cell motility
EI285_RS08065	COG4786	Flagellar basal body rod
EI285_RS08075	COG0745	RESPONSE REGULATOR receiver
EI285_RS08080	COG4786	Flagellar basal body rod
EI285_RS08095	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EI285_RS08105	COG0228	four-way junction DNA binding
EI285_RS08110	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EI285_RS08115	COG0564	pseudouridine synthase activity
EI285_RS08120	COG1519	Transferase
EI285_RS08120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EI285_RS08130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EI285_RS08135	COG0752	glycyl-tRNA synthetase alpha subunit
EI285_RS08145	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EI285_RS08155	COG0826	peptidase U32
EI285_RS08160	COG0840	transmembrane signaling receptor activity
EI285_RS08160	COG0840	transmembrane signaling receptor activity
EI285_RS08165	COG0497	DNA recombination
EI285_RS08170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EI285_RS08175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EI285_RS08180	COG0049	tRNA binding
EI285_RS08185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EI285_RS08205	COG1840	ABC-type Fe3 transport system, periplasmic component
EI285_RS08215	COG3842	ATPase activity
EI285_RS08235	COG1393	Belongs to the ArsC family
EI285_RS08240	COG1335	isochorismatase
EI285_RS08250	COG0181	hydroxymethylbilane synthase activity
EI285_RS08255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EI285_RS08260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EI285_RS08265	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EI285_RS08270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EI285_RS08275	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EI285_RS08280	COG0450	alkyl hydroperoxide reductase
EI285_RS08290	COG0105	UTP biosynthetic process
EI285_RS08300	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EI285_RS08305	COG0416	fatty acid biosynthetic process
EI285_RS08310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EI285_RS08330	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EI285_RS08335	COG1053	succinate dehydrogenase
EI285_RS08345	COG1007	ATP synthesis coupled electron transport
EI285_RS08355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EI285_RS08360	COG0713	ATP synthesis coupled electron transport
EI285_RS08365	COG0839	Belongs to the complex I subunit 6 family
EI285_RS08370	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EI285_RS08375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EI285_RS08380	COG1034	ATP synthesis coupled electron transport
EI285_RS08385	COG0372	Belongs to the citrate synthase family
EI285_RS08395	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EI285_RS08400	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EI285_RS08400	COG0649	NAD binding
EI285_RS08405	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EI285_RS08410	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EI285_RS08415	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EI285_RS08430	COG3610	response to peptide
EI285_RS08435	COG3610	response to peptide
EI285_RS08445	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EI285_RS08450	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EI285_RS08485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EI285_RS08495	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EI285_RS08505	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EI285_RS08510	COG2828	Protein conserved in bacteria
EI285_RS08515	COG0741	lytic transglycosylase activity
EI285_RS08520	COG0469	pyruvate kinase activity
EI285_RS08530	COG0792	nuclease activity
EI285_RS08535	COG0156	8-amino-7-oxononanoate synthase activity
EI285_RS08540	COG0288	reversible hydration of carbon dioxide
EI285_RS08550	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EI285_RS08560	COG2121	Domain of unknown function (DUF374)
EI285_RS08565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EI285_RS08575	COG0195	Participates in both transcription termination and antitermination
EI285_RS08580	COG0215	cysteine-tRNA ligase activity
EI285_RS08585	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EI285_RS08590	COG0629	single-stranded DNA binding
EI285_RS08595	COG0360	Binds together with S18 to 16S ribosomal RNA
EI285_RS08610	COG0557	exoribonuclease II activity
EI285_RS08615	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EI285_RS08630	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EI285_RS08635	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EI285_RS08640	COG0492	ferredoxin-NADP+ reductase activity
EI285_RS08645	COG3118	belongs to the thioredoxin family
EI285_RS08650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EI285_RS08660	COG4771	TonB-dependent receptor
EI285_RS08665	COG0642	Histidine kinase
EI285_RS08670	COG0745	RESPONSE REGULATOR receiver
EI285_RS08680	COG0129	dihydroxy-acid dehydratase activity
EI285_RS08700	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EI285_RS08705	COG0585	pseudouridine synthase activity
EI285_RS08720	COG0793	Belongs to the peptidase S41A family
EI285_RS08725	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EI285_RS08730	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EI285_RS08735	COG0047	phosphoribosylformylglycinamidine synthase activity
EI285_RS08745	COG0204	Acyl-transferase
EI285_RS08750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EI285_RS08755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EI285_RS08760	COG0018	arginyl-trna synthetase
EI285_RS08770	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EI285_RS08775	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EI285_RS08780	COG0126	phosphoglycerate kinase activity
EI285_RS08785	COG0149	triose-phosphate isomerase activity
EI285_RS08790	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EI285_RS08795	COG0019	diaminopimelate decarboxylase activity
EI285_RS08800	COG1605	Chorismate mutase
EI285_RS08800	COG0077	Prephenate dehydratase
EI285_RS08805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EI285_RS08810	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EI285_RS08815	COG1858	cytochrome C peroxidase
EI285_RS08825	COG0424	maF-like protein
EI285_RS08855	COG2203	Gaf domain
EI285_RS08855	COG4251	negative regulation of phosphorylation
EI285_RS08855	COG3706	GGDEF domain
EI285_RS08855	COG5001	Diguanylate cyclase
EI285_RS08865	COG2204	response regulator
EI285_RS08880	COG0189	ligase activity
EI285_RS08895	COG2199	diguanylate cyclase activity
EI285_RS08895	COG3287	FIST C domain
EI285_RS08895	COG2200	EAL domain
EI285_RS08915	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EI285_RS08920	COG0443	Heat shock 70 kDa protein
EI285_RS08925	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EI285_RS08965	COG0309	Hydrogenase expression formation protein (HypE)
EI285_RS08970	COG0409	Hydrogenase expression formation protein
EI285_RS08975	COG0298	carbon dioxide binding
EI285_RS08980	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EI285_RS08990	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EI285_RS08995	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EI285_RS09000	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EI285_RS09005	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
EI285_RS09010	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
EI285_RS09015	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
EI285_RS09020	COG0101	tRNA pseudouridine synthase activity
EI285_RS09035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EI285_RS09040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EI285_RS09045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EI285_RS09055	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EI285_RS09060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EI285_RS09150	COG2089	acid synthase
EI285_RS09155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EI285_RS09175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EI285_RS09180	COG4221	oxidoreductase activity
EI285_RS09185	COG1028	Short-chain dehydrogenase reductase Sdr
EI285_RS09200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EI285_RS09210	COG1083	cytidylyl-transferase
EI285_RS09220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EI285_RS09225	COG1086	Polysaccharide biosynthesis protein
EI285_RS09235	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EI285_RS09240	COG0733	neurotransmitter:sodium symporter activity
EI285_RS09245	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EI285_RS09250	COG0659	secondary active sulfate transmembrane transporter activity
EI285_RS09260	COG1222	aaa ATPase
EI285_RS09270	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
EI285_RS09275	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EI285_RS09295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EI285_RS09300	COG0148	phosphopyruvate hydratase activity
EI285_RS09315	COG0445	tRNA wobble uridine modification
EI285_RS09330	COG1077	Cell shape determining protein MreB Mrl
EI285_RS09335	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EI285_RS09340	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EI285_RS09345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EI285_RS09350	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EI285_RS09355	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EI285_RS09390	COG0670	Belongs to the BI1 family
EI285_RS09395	COG0352	thiamine-phosphate diphosphorylase activity
EI285_RS09405	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EI285_RS09410	COG0233	cytoplasmic translational termination
EI285_RS09415	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EI285_RS09435	COG3022	response to hydroperoxide
EI285_RS09470	COG3022	response to hydroperoxide
EI285_RS09500	COG3022	response to hydroperoxide
EI285_RS09520	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EI285_RS09525	COG1012	belongs to the aldehyde dehydrogenase family
EI285_RS09535	COG0546	phosphoglycolate phosphatase activity
EI285_RS09540	COG0783	Belongs to the Dps family
EI285_RS09545	COG2814	Major facilitator Superfamily
EI285_RS09550	COG0784	Response regulator, receiver
EI285_RS09550	COG4191	Histidine kinase
EI285_RS09565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EI285_RS09570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EI285_RS09585	COG0840	transmembrane signaling receptor activity
EI285_RS09590	COG2081	HI0933 family
EI285_RS09605	COG1959	2 iron, 2 sulfur cluster binding
EI285_RS09625	COG0175	sulfate reduction
EI285_RS09630	COG2895	sulfate adenylyltransferase (ATP) activity
EI285_RS09640	COG0133	tryptophan synthase activity
EI285_RS09660	COG1408	metallophosphoesterase
EI285_RS09665	COG1999	signal sequence binding
EI285_RS09680	COG2703	oxygen carrier activity
EI285_RS09685	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EI285_RS09690	COG4208	sulfate ABC transporter
EI285_RS09695	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EI285_RS09705	COG2199	diguanylate cyclase activity
EI285_RS09705	COG2200	EAL domain
EI285_RS09705	COG3287	FIST C domain
EI285_RS09720	COG0071	Belongs to the small heat shock protein (HSP20) family
EI285_RS09730	COG1217	gtp-binding protein TYPA
EI285_RS09735	COG2391	methyltransferase activity
EI285_RS09740	COG0425	Belongs to the sulfur carrier protein TusA family
EI285_RS09745	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
EI285_RS09750	COG2860	membrane
EI285_RS09765	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group