locus-tag	class	description
ATR_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ATR_RS00010	COG0592	DNA-directed DNA polymerase activity
ATR_RS00015	COG0187	DNA topoisomerase II activity
ATR_RS00020	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ATR_RS00040	COG0500	methyltransferase
ATR_RS00050	COG1120	ATPase activity
ATR_RS00055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ATR_RS00070	COG3842	ATPase activity
ATR_RS00100	COG0583	DNA-binding transcription factor activity
ATR_RS00110	COG0133	tryptophan synthase activity
ATR_RS00115	COG2353	YceI-like domain
ATR_RS00140	COG0642	Histidine kinase
ATR_RS00145	COG0745	RESPONSE REGULATOR receiver
ATR_RS00150	COG0724	RNA recognition motif
ATR_RS00155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ATR_RS00160	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ATR_RS00175	COG0107	imidazoleglycerol-phosphate synthase activity
ATR_RS00180	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ATR_RS00185	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ATR_RS00190	COG0517	IMP dehydrogenase activity
ATR_RS00190	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ATR_RS00195	COG1187	pseudouridine synthase activity
ATR_RS00200	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ATR_RS00200	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ATR_RS00205	COG1981	membrane
ATR_RS00210	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ATR_RS00220	COG0367	asparagine synthase
ATR_RS00230	COG0306	phosphate transporter
ATR_RS00235	COG0513	Belongs to the DEAD box helicase family
ATR_RS00240	COG0439	Biotin carboxylase
ATR_RS00245	COG0511	ligase activity, forming carbon-carbon bonds
ATR_RS00250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ATR_RS00260	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ATR_RS00265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ATR_RS00270	COG0604	alcohol dehydrogenase
ATR_RS00280	COG2885	chlorophyll binding
ATR_RS00280	COG3047	cAMP biosynthetic process
ATR_RS00285	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ATR_RS00290	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ATR_RS00295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ATR_RS00300	COG0564	pseudouridine synthase activity
ATR_RS00305	COG0460	homoserine dehydrogenase
ATR_RS00310	COG0436	Aminotransferase
ATR_RS00325	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ATR_RS00330	COG0254	rRNA binding
ATR_RS00335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ATR_RS00380	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ATR_RS00385	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ATR_RS00390	COG1854	S-ribosylhomocysteine lyase activity
ATR_RS00400	COG1686	Belongs to the peptidase S11 family
ATR_RS00410	COG1410	methionine synthase
ATR_RS00410	COG0646	methionine synthase
ATR_RS00435	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ATR_RS00435	COG0140	phosphoribosyl-ATP diphosphatase activity
ATR_RS00445	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ATR_RS00450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ATR_RS00460	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ATR_RS00470	COG0352	thiamine-phosphate diphosphorylase activity
ATR_RS00470	COG0351	phosphomethylpyrimidine kinase
ATR_RS00490	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ATR_RS00495	COG0315	cyclic pyranopterin monophosphate synthase activity
ATR_RS00510	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ATR_RS00515	COG0587	DNA-directed DNA polymerase activity
ATR_RS00520	COG0693	protein deglycase activity
ATR_RS00535	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ATR_RS00535	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ATR_RS00540	COG0504	CTP synthase activity
ATR_RS00545	COG0348	domain, Protein
ATR_RS00555	COG0237	dephospho-CoA kinase activity
ATR_RS00560	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ATR_RS00565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ATR_RS00570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ATR_RS00575	COG4895	conserved protein (DUF2196)
ATR_RS00600	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ATR_RS00605	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ATR_RS00610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ATR_RS00620	COG0505	Belongs to the CarA family
ATR_RS00645	COG0745	RESPONSE REGULATOR receiver
ATR_RS00650	COG0642	Histidine kinase
ATR_RS00655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ATR_RS00660	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ATR_RS00665	COG0540	Belongs to the ATCase OTCase family
ATR_RS00675	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ATR_RS00680	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ATR_RS00685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ATR_RS00690	COG0268	Binds directly to 16S ribosomal RNA
ATR_RS00695	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ATR_RS00700	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ATR_RS00705	COG0745	RESPONSE REGULATOR receiver
ATR_RS00710	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ATR_RS00710	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ATR_RS00720	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ATR_RS00725	COG0489	protein tyrosine kinase activity
ATR_RS00735	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ATR_RS00740	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ATR_RS00745	COG5002	protein histidine kinase activity
ATR_RS00750	COG0745	RESPONSE REGULATOR receiver
ATR_RS00765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ATR_RS00770	COG0581	inorganic phosphate transmembrane transporter activity
ATR_RS00775	COG0573	inorganic phosphate transmembrane transporter activity
ATR_RS00785	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ATR_RS00790	COG2824	Alkylphosphonate utilization operon protein PhnA
ATR_RS00825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ATR_RS00835	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ATR_RS00840	COG0601	transmembrane transport
ATR_RS00845	COG0736	holo-[acyl-carrier-protein] synthase activity
ATR_RS00860	COG0786	glutamate:sodium symporter activity
ATR_RS00865	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ATR_RS00875	COG0560	Phosphoserine phosphatase
ATR_RS00885	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ATR_RS00890	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ATR_RS00900	COG0288	reversible hydration of carbon dioxide
ATR_RS00905	COG0156	8-amino-7-oxononanoate synthase activity
ATR_RS00910	COG0792	nuclease activity
ATR_RS00925	COG5002	protein histidine kinase activity
ATR_RS00930	COG0745	RESPONSE REGULATOR receiver
ATR_RS00945	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ATR_RS00980	COG1987	bacterial-type flagellum assembly
ATR_RS00990	COG1706	bacterial-type flagellum-dependent cell motility
ATR_RS01005	COG0347	Belongs to the P(II) protein family
ATR_RS01010	COG0004	ammonium transporteR
ATR_RS01015	COG0666	response to abiotic stimulus
ATR_RS01025	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ATR_RS01040	COG1742	UPF0060 membrane protein
ATR_RS01050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ATR_RS01065	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ATR_RS01100	COG0511	ligase activity, forming carbon-carbon bonds
ATR_RS01100	COG5016	pyruvate
ATR_RS01130	COG2022	thiamine diphosphate biosynthetic process
ATR_RS01140	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ATR_RS01140	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ATR_RS01150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ATR_RS01165	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ATR_RS01170	COG0575	Belongs to the CDS family
ATR_RS01200	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ATR_RS01205	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ATR_RS01210	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ATR_RS01220	COG0446	pyridine nucleotide-disulphide oxidoreductase
ATR_RS01225	COG0746	molybdenum cofactor guanylyltransferase activity
ATR_RS01230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ATR_RS01235	COG1393	Belongs to the ArsC family
ATR_RS01240	COG2828	Protein conserved in bacteria
ATR_RS01245	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ATR_RS01265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ATR_RS01280	COG2199	diguanylate cyclase activity
ATR_RS01280	COG3287	FIST C domain
ATR_RS01280	COG2200	EAL domain
ATR_RS01295	COG0189	ligase activity
ATR_RS01320	COG0791	NLP P60 protein
ATR_RS01330	COG0424	maF-like protein
ATR_RS01345	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ATR_RS01350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ATR_RS01355	COG0077	Prephenate dehydratase
ATR_RS01355	COG1605	Chorismate mutase
ATR_RS01360	COG0019	diaminopimelate decarboxylase activity
ATR_RS01365	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ATR_RS01370	COG0149	triose-phosphate isomerase activity
ATR_RS01375	COG0126	phosphoglycerate kinase activity
ATR_RS01385	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ATR_RS01395	COG0018	arginyl-trna synthetase
ATR_RS01405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ATR_RS01410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ATR_RS01415	COG0204	Acyl-transferase
ATR_RS01425	COG0047	phosphoribosylformylglycinamidine synthase activity
ATR_RS01430	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ATR_RS01435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ATR_RS01440	COG0793	Belongs to the peptidase S41A family
ATR_RS01455	COG0585	pseudouridine synthase activity
ATR_RS01475	COG3842	ATPase activity
ATR_RS01505	COG0129	dihydroxy-acid dehydratase activity
ATR_RS01515	COG0745	RESPONSE REGULATOR receiver
ATR_RS01520	COG0642	Histidine kinase
ATR_RS01545	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ATR_RS01550	COG3118	belongs to the thioredoxin family
ATR_RS01555	COG0492	ferredoxin-NADP+ reductase activity
ATR_RS01560	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ATR_RS01565	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ATR_RS01570	COG1242	4 iron, 4 sulfur cluster binding
ATR_RS01585	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ATR_RS01590	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ATR_RS01595	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ATR_RS01600	COG3278	Belongs to the heme-copper respiratory oxidase family
ATR_RS01640	COG1335	isochorismatase
ATR_RS01645	COG3576	pyridoxamine 5-phosphate
ATR_RS01650	COG0181	hydroxymethylbilane synthase activity
ATR_RS01660	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ATR_RS01665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ATR_RS01675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ATR_RS01680	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ATR_RS01685	COG0450	alkyl hydroperoxide reductase
ATR_RS01695	COG0105	UTP biosynthetic process
ATR_RS01705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ATR_RS01710	COG0416	fatty acid biosynthetic process
ATR_RS01715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ATR_RS01735	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ATR_RS01740	COG1053	succinate dehydrogenase
ATR_RS01750	COG1007	ATP synthesis coupled electron transport
ATR_RS01760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ATR_RS01765	COG0713	ATP synthesis coupled electron transport
ATR_RS01770	COG0839	Belongs to the complex I subunit 6 family
ATR_RS01775	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ATR_RS01780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ATR_RS01790	COG0372	Belongs to the citrate synthase family
ATR_RS01800	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ATR_RS01805	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ATR_RS01805	COG0649	NAD binding
ATR_RS01810	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ATR_RS01815	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ATR_RS01820	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ATR_RS01825	COG3610	response to peptide
ATR_RS01830	COG2966	Psort location CytoplasmicMembrane, score
ATR_RS01835	COG2183	response to ionizing radiation
ATR_RS01855	COG0741	lytic transglycosylase activity
ATR_RS01855	COG1196	nuclear chromosome segregation
ATR_RS01855	COG0739	heme binding
ATR_RS01865	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ATR_RS01875	COG4191	Histidine kinase
ATR_RS01880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ATR_RS01885	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ATR_RS01890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ATR_RS01910	COG2326	polyphosphate kinase activity
ATR_RS01920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ATR_RS01925	COG0571	ribonuclease III activity
ATR_RS01935	COG0358	DNA primase activity
ATR_RS01950	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ATR_RS01955	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ATR_RS01960	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ATR_RS01965	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ATR_RS01970	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ATR_RS01990	COG1192	Involved in chromosome partitioning
ATR_RS01995	COG1475	DNA binding
ATR_RS02005	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ATR_RS02010	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ATR_RS02015	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ATR_RS02020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ATR_RS02025	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ATR_RS02030	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ATR_RS02035	COG0811	peptide transport
ATR_RS02040	COG0848	biopolymer transport protein
ATR_RS02050	COG0823	Involved in the tonB-independent uptake of proteins
ATR_RS02065	COG1047	Peptidyl-prolyl cis-trans
ATR_RS02070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ATR_RS02075	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ATR_RS02080	COG1027	Aspartate ammonia-lyase
ATR_RS02090	COG3012	SEC-C Motif Domain Protein
ATR_RS02100	COG0668	transmembrane transport
ATR_RS02110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ATR_RS02115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ATR_RS02125	COG0010	Belongs to the arginase family
ATR_RS02130	COG3706	GGDEF domain
ATR_RS02130	COG5001	Diguanylate cyclase
ATR_RS02130	COG2203	Gaf domain
ATR_RS02130	COG4251	negative regulation of phosphorylation
ATR_RS02135	COG2264	protein methyltransferase activity
ATR_RS02140	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ATR_RS02170	COG2995	paraquat-inducible protein a
ATR_RS02180	COG0753	catalase activity
ATR_RS02195	COG0326	Molecular chaperone. Has ATPase activity
ATR_RS02210	COG0513	Belongs to the DEAD box helicase family
ATR_RS02225	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ATR_RS02230	COG0259	pyridoxamine-phosphate oxidase activity
ATR_RS02235	COG2199	diguanylate cyclase activity
ATR_RS02235	COG2200	EAL domain
ATR_RS02235	COG3287	FIST C domain
ATR_RS02305	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ATR_RS02345	COG0528	UMP kinase activity
ATR_RS02350	COG1758	RNA polymerase activity
ATR_RS02355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ATR_RS02360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ATR_RS02370	COG0860	N-Acetylmuramoyl-L-alanine amidase
ATR_RS02385	COG0193	aminoacyl-tRNA hydrolase activity
ATR_RS02390	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ATR_RS02395	COG0306	phosphate transporter
ATR_RS02405	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ATR_RS02410	COG0697	spore germination
ATR_RS02415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ATR_RS02425	COG1295	ribonuclease BN
ATR_RS02430	COG0277	FAD linked oxidase domain protein
ATR_RS02440	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ATR_RS02445	COG2226	methyltransferase
ATR_RS02450	COG0196	riboflavin kinase activity
ATR_RS02465	COG1739	Uncharacterized protein family UPF0029
ATR_RS02485	COG0483	inositol monophosphate 1-phosphatase activity
ATR_RS02490	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ATR_RS02500	COG0859	PFAM glycosyl transferase family 9
ATR_RS02515	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ATR_RS02520	COG2194	sulfuric ester hydrolase activity
ATR_RS02525	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ATR_RS02530	COG1088	dTDP-glucose 4,6-dehydratase activity
ATR_RS02560	COG1216	Glycosyl transferase, family 2
ATR_RS02560	COG1442	glycosyl transferase family 8
ATR_RS02565	COG2194	sulfuric ester hydrolase activity
ATR_RS02600	COG0859	PFAM glycosyl transferase family 9
ATR_RS02615	COG1368	sulfuric ester hydrolase activity
ATR_RS02620	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ATR_RS02625	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ATR_RS02625	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ATR_RS02645	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ATR_RS02655	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ATR_RS02670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ATR_RS02680	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ATR_RS02725	COG2200	EAL domain
ATR_RS02725	COG2199	diguanylate cyclase activity
ATR_RS02730	COG2217	Heavy metal translocating P-type atpase
ATR_RS02740	COG2863	cytochrome
ATR_RS02765	COG0581	inorganic phosphate transmembrane transporter activity
ATR_RS02770	COG0573	inorganic phosphate transmembrane transporter activity
ATR_RS02775	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ATR_RS02795	COG4783	chaperone-mediated protein folding
ATR_RS02870	COG0242	peptide deformylase activity
ATR_RS02875	COG0740	serine-type endopeptidase activity
ATR_RS02880	COG0544	peptidyl-prolyl cis-trans isomerase activity
ATR_RS02885	COG2326	polyphosphate kinase activity
ATR_RS02905	COG0606	chelatase, subunit chli
ATR_RS02975	COG0542	response to heat
ATR_RS02990	COG0606	chelatase, subunit chli
ATR_RS03010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ATR_RS03010	COG0301	tRNA thio-modification
ATR_RS03015	COG0708	Exodeoxyribonuclease III
ATR_RS03035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ATR_RS03040	COG0772	Belongs to the SEDS family
ATR_RS03045	COG0768	penicillin binding
ATR_RS03050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ATR_RS03055	COG1858	cytochrome C peroxidase
ATR_RS03085	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ATR_RS03105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ATR_RS03110	COG4608	Belongs to the ABC transporter superfamily
ATR_RS03115	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ATR_RS03150	COG1522	sequence-specific DNA binding
ATR_RS03155	COG1648	precorrin-2 dehydrogenase activity
ATR_RS03155	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ATR_RS03165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ATR_RS03165	COG1648	precorrin-2 dehydrogenase activity
ATR_RS03175	COG0535	radical SAM domain protein
ATR_RS03185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ATR_RS03195	COG2010	Cytochrome c
ATR_RS03200	COG3256	nitric oxide reductase
ATR_RS03205	COG2010	Cytochrome c
ATR_RS03220	COG1355	regulation of microtubule-based process
ATR_RS03225	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ATR_RS03240	COG1121	(ABC) transporter
ATR_RS03245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ATR_RS03250	COG2996	Protein conserved in bacteria
ATR_RS03255	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ATR_RS03260	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
ATR_RS03275	COG0525	valine-tRNA ligase activity
ATR_RS03295	COG2814	Major facilitator Superfamily
ATR_RS03300	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ATR_RS03320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ATR_RS03325	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ATR_RS03330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ATR_RS03355	COG0439	Biotin carboxylase
ATR_RS03365	COG2166	iron-sulfur cluster assembly
ATR_RS03370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ATR_RS03380	COG0396	ATPase activity
ATR_RS03385	COG0719	Fe-S assembly protein
ATR_RS03395	COG2239	Acts as a magnesium transporter
ATR_RS03400	COG3706	GGDEF domain
ATR_RS03405	COG0165	Argininosuccinate lyase
ATR_RS03410	COG0556	nucleotide-excision repair
ATR_RS03420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ATR_RS03425	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ATR_RS03430	COG0835	chemotaxis
ATR_RS03430	COG0784	Response regulator, receiver
ATR_RS03440	COG0582	viral genome integration into host DNA
ATR_RS03515	COG0840	transmembrane signaling receptor activity
ATR_RS03570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ATR_RS03680	COG3451	type IV secretory pathway VirB4
ATR_RS03695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ATR_RS03700	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ATR_RS03705	COG0585	pseudouridine synthase activity
ATR_RS03715	COG0840	transmembrane signaling receptor activity
ATR_RS03720	COG0632	four-way junction helicase activity
ATR_RS03725	COG1181	Belongs to the D-alanine--D-alanine ligase family
ATR_RS03735	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ATR_RS03750	COG0051	transcription antitermination factor activity, RNA binding
ATR_RS03755	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ATR_RS03760	COG0088	Forms part of the polypeptide exit tunnel
ATR_RS03765	COG0089	rRNA binding
ATR_RS03770	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ATR_RS03775	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ATR_RS03780	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ATR_RS03785	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ATR_RS03790	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ATR_RS03795	COG0255	Belongs to the universal ribosomal protein uL29 family
ATR_RS03800	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ATR_RS03805	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ATR_RS03810	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ATR_RS03815	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ATR_RS03820	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ATR_RS03825	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ATR_RS03830	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ATR_RS03835	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ATR_RS03840	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ATR_RS03845	COG0200	Binds to the 23S rRNA
ATR_RS03850	COG0201	protein transport
ATR_RS03855	COG0024	Methionine aminopeptidase
ATR_RS03860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ATR_RS03865	COG1573	uracil-dna glycosylase
ATR_RS03875	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ATR_RS03880	COG1032	radical SAM domain protein
ATR_RS03890	COG0563	adenylate kinase activity
ATR_RS03910	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ATR_RS03925	COG4535	Mg2 and Co2 transporter CorC
ATR_RS03950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ATR_RS03955	COG0508	dehydrogenase complex catalyzes the overall conversion of
ATR_RS03960	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ATR_RS03965	COG0095	Lipoate-protein ligase
ATR_RS03970	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ATR_RS03980	COG3706	GGDEF domain
ATR_RS03985	COG0488	(ABC) transporter
ATR_RS03990	COG2258	MOSC domain
ATR_RS04000	COG0446	pyridine nucleotide-disulphide oxidoreductase
ATR_RS04020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ATR_RS04030	COG0849	cell division
ATR_RS04035	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ATR_RS04050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ATR_RS04055	COG1722	exodeoxyribonuclease VII activity
ATR_RS04060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ATR_RS04070	COG0113	porphobilinogen synthase activity
ATR_RS04075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ATR_RS04080	COG0357	Ribosomal RNA small subunit methyltransferase G
ATR_RS04100	COG1793	dna ligase
ATR_RS04105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ATR_RS04110	COG0066	3-isopropylmalate dehydratase activity
ATR_RS04115	COG0473	3-isopropylmalate dehydrogenase activity
ATR_RS04130	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ATR_RS04135	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ATR_RS04140	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ATR_RS04145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ATR_RS04150	COG0202	RNA polymerase activity
ATR_RS04155	COG0203	ribosomal protein L17
ATR_RS04160	COG0154	amidase activity
ATR_RS04165	COG0516	GMP reductase activity
ATR_RS04165	COG0517	IMP dehydrogenase activity
ATR_RS04170	COG0628	permease
ATR_RS04175	COG2255	four-way junction helicase activity
ATR_RS04180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ATR_RS04185	COG0159	tryptophan synthase activity
ATR_RS04200	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ATR_RS04215	COG0137	argininosuccinate synthase activity
ATR_RS04220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ATR_RS04225	COG0742	ribosomal rna small subunit methyltransferase
ATR_RS04230	COG1418	mRNA catabolic process
ATR_RS04245	COG0552	protein localization to endoplasmic reticulum
ATR_RS04265	COG2249	NAD(P)H dehydrogenase (quinone) activity
ATR_RS04270	COG0778	Nitroreductase
ATR_RS04280	COG0488	(ABC) transporter
ATR_RS04285	COG1607	acyl-coa hydrolase
ATR_RS04290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ATR_RS04305	COG0754	glutathionylspermidine amidase activity
ATR_RS04315	COG0513	Belongs to the DEAD box helicase family
ATR_RS04320	COG2885	chlorophyll binding
ATR_RS04320	COG3047	cAMP biosynthetic process
ATR_RS04330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ATR_RS04340	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ATR_RS04355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ATR_RS04355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ATR_RS04365	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ATR_RS04390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ATR_RS04395	COG0612	Peptidase, M16
ATR_RS04400	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ATR_RS04405	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ATR_RS04410	COG0287	Prephenate dehydrogenase
ATR_RS04425	COG1921	L-seryl-tRNASec selenium transferase activity
ATR_RS04440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ATR_RS04445	COG0135	phosphoribosylanthranilate isomerase activity
ATR_RS04450	COG2176	DNA-directed DNA polymerase activity
ATR_RS04455	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ATR_RS04460	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ATR_RS04465	COG2200	EAL domain
ATR_RS04465	COG2199	diguanylate cyclase activity
ATR_RS04465	COG3287	FIST C domain
ATR_RS04475	COG0492	ferredoxin-NADP+ reductase activity
ATR_RS04480	COG0596	Alpha beta hydrolase
ATR_RS04500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ATR_RS04500	COG0519	Catalyzes the synthesis of GMP from XMP
ATR_RS04505	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ATR_RS04515	COG1451	nucleotide metabolic process
ATR_RS04520	COG0436	Aminotransferase
ATR_RS04525	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ATR_RS04555	COG1696	Membrane protein involved in D-alanine export
ATR_RS04565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ATR_RS04565	COG0475	glutathione-regulated potassium exporter activity
ATR_RS04575	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ATR_RS04595	COG4263	nitrous-oxide reductase activity
ATR_RS04610	COG0437	4 iron, 4 sulfur cluster binding
ATR_RS04625	COG0348	domain, Protein
ATR_RS04630	COG1122	ATPase activity
ATR_RS04650	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ATR_RS04660	COG0546	phosphoglycolate phosphatase activity
ATR_RS04685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ATR_RS04695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ATR_RS04715	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ATR_RS04725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ATR_RS04730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ATR_RS04740	COG0521	Mo-molybdopterin cofactor biosynthetic process
ATR_RS04745	COG1090	epimerase
ATR_RS04750	COG0415	Belongs to the DNA photolyase family
ATR_RS04765	COG0653	protein targeting
ATR_RS04770	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ATR_RS04780	COG2195	Cleaves the N-terminal amino acid of tripeptides
ATR_RS04785	COG1333	cytochrome c biogenesis protein
ATR_RS04785	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ATR_RS04800	COG0500	methyltransferase
ATR_RS04805	COG4251	negative regulation of phosphorylation
ATR_RS04805	COG3706	GGDEF domain
ATR_RS04805	COG2203	Gaf domain
ATR_RS04805	COG5001	Diguanylate cyclase
ATR_RS04815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ATR_RS04835	COG0484	heat shock protein binding
ATR_RS04840	COG0582	viral genome integration into host DNA
ATR_RS04845	COG2201	protein-glutamate methylesterase activity
ATR_RS04850	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ATR_RS04855	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ATR_RS04860	COG2198	Histidine kinase
ATR_RS04860	COG0643	Histidine kinase
ATR_RS04870	COG1185	polyribonucleotide nucleotidyltransferase activity
ATR_RS04880	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ATR_RS04900	COG1160	GTP binding
ATR_RS04905	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ATR_RS04910	COG1196	nuclear chromosome segregation
ATR_RS04910	COG1674	ftsk spoiiie
ATR_RS04915	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ATR_RS04920	COG0440	acetolactate synthase activity
ATR_RS04925	COG0028	Belongs to the TPP enzyme family
ATR_RS04960	COG0037	tRNA processing
ATR_RS04980	COG2321	neutral zinc metallopeptidase
ATR_RS04985	COG1322	Protein conserved in bacteria
ATR_RS04990	COG0501	Belongs to the peptidase M48B family
ATR_RS05000	COG0824	Thioesterase
ATR_RS05015	COG0339	signal peptide processing
ATR_RS05020	COG2890	protein-(glutamine-N5) methyltransferase activity
ATR_RS05025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ATR_RS05030	COG0494	nUDIX hydrolase
ATR_RS05035	COG0527	aspartate kinase activity
ATR_RS05050	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ATR_RS05065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ATR_RS05065	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ATR_RS05070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ATR_RS05075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ATR_RS05090	COG1119	ATPase activity
ATR_RS05100	COG1253	flavin adenine dinucleotide binding
ATR_RS05105	COG1193	negative regulation of DNA recombination
ATR_RS05125	COG0039	L-malate dehydrogenase activity
ATR_RS05150	COG0275	rRNA processing
ATR_RS05160	COG0776	regulation of translation
ATR_RS05180	COG2201	protein-glutamate methylesterase activity
ATR_RS05195	COG0484	heat shock protein binding
ATR_RS05200	COG0789	Transcriptional regulator
ATR_RS05205	COG0861	Integral membrane protein TerC family
ATR_RS05210	COG1663	tetraacyldisaccharide 4'-kinase activity
ATR_RS05215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ATR_RS05220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ATR_RS05245	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ATR_RS05250	COG0805	protein transport
ATR_RS05255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ATR_RS05260	COG0667	Aldo Keto reductase
ATR_RS05285	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ATR_RS05290	COG0488	(ABC) transporter
ATR_RS05300	COG0739	heme binding
ATR_RS05310	COG2199	diguanylate cyclase activity
ATR_RS05315	COG1942	4-Oxalocrotonate Tautomerase
ATR_RS05320	COG0583	DNA-binding transcription factor activity
ATR_RS05325	COG0134	indole-3-glycerol-phosphate synthase activity
ATR_RS05335	COG0727	PFAM Uncharacterised protein family (UPF0153)
ATR_RS05340	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ATR_RS05350	COG0674	pyruvate-flavodoxin oxidoreductase activity
ATR_RS05350	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ATR_RS05355	COG1013	pyruvate-flavodoxin oxidoreductase activity
ATR_RS05365	COG0157	Belongs to the NadC ModD family
ATR_RS05375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ATR_RS05375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ATR_RS05380	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ATR_RS05390	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ATR_RS05395	COG0735	belongs to the Fur family
ATR_RS05405	COG0728	peptidoglycan biosynthetic process
ATR_RS05410	COG1132	(ABC) transporter
ATR_RS05415	COG0167	dihydroorotate dehydrogenase activity
ATR_RS05425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ATR_RS05430	COG1028	Short-chain dehydrogenase reductase Sdr
ATR_RS05435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ATR_RS05440	COG0750	zinc metalloprotease
ATR_RS05445	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ATR_RS05450	COG0840	transmembrane signaling receptor activity
ATR_RS05455	COG0840	transmembrane signaling receptor activity
ATR_RS05465	COG0642	Histidine kinase
ATR_RS05470	COG0745	RESPONSE REGULATOR receiver
ATR_RS05480	COG1132	(ABC) transporter
ATR_RS05495	COG2814	Major facilitator Superfamily
ATR_RS05505	COG0303	'Molybdopterin
ATR_RS05515	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ATR_RS05525	COG0437	4 iron, 4 sulfur cluster binding
ATR_RS05560	COG2204	response regulator
ATR_RS05565	COG0709	Synthesizes selenophosphate from selenide and ATP
ATR_RS05570	COG0210	DNA helicase
ATR_RS05575	COG0569	domain protein
ATR_RS05575	COG0475	glutathione-regulated potassium exporter activity
ATR_RS05580	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ATR_RS05655	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ATR_RS05660	COG0840	transmembrane signaling receptor activity
ATR_RS05665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ATR_RS05670	COG0322	excinuclease ABC activity
ATR_RS05675	COG0840	transmembrane signaling receptor activity
ATR_RS05690	COG0840	transmembrane signaling receptor activity
ATR_RS05695	COG1944	ATP diphosphatase activity
ATR_RS05700	COG2171	N-acyltransferase activity
ATR_RS05705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ATR_RS05730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ATR_RS05735	COG2081	HI0933 family
ATR_RS05740	COG0726	polysaccharide deacetylase
ATR_RS05775	COG0217	transcriptional regulatory protein
ATR_RS05795	COG1611	Belongs to the LOG family
ATR_RS05800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ATR_RS05820	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ATR_RS05835	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ATR_RS05855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ATR_RS05860	COG1696	Membrane protein involved in D-alanine export
ATR_RS05870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ATR_RS05915	COG0419	ATPase involved in DNA repair
ATR_RS05920	COG0420	3'-5' exonuclease activity
ATR_RS05935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ATR_RS05955	COG2267	carboxylic ester hydrolase activity
ATR_RS05970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ATR_RS05980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ATR_RS06000	COG2986	histidine ammonia-lyase
ATR_RS06005	COG1028	Short-chain dehydrogenase reductase Sdr
ATR_RS06030	COG1131	(ABC) transporter
ATR_RS06045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ATR_RS06070	COG0330	HflC and HflK could
ATR_RS06075	COG5002	protein histidine kinase activity
ATR_RS06080	COG0745	RESPONSE REGULATOR receiver
ATR_RS06105	COG1114	Component of the transport system for branched-chain amino acids
ATR_RS06115	COG0788	formyltetrahydrofolate deformylase activity
ATR_RS06120	COG0281	malic enzyme
ATR_RS06120	COG0280	phosphate acetyltransferase
ATR_RS06125	COG1496	oxidoreductase activity
ATR_RS06130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ATR_RS06135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ATR_RS06170	COG1666	GTP binding
ATR_RS06175	COG2363	Small membrane protein
ATR_RS06180	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ATR_RS06185	COG1049	propionate catabolic process, 2-methylcitrate cycle
ATR_RS06195	COG3258	Cytochrome c
ATR_RS06210	COG0642	Histidine kinase
ATR_RS06215	COG2076	Multidrug Resistance protein
ATR_RS06225	COG1881	PFAM PEBP family protein
ATR_RS06230	COG0583	DNA-binding transcription factor activity
ATR_RS06235	COG2855	membrane
ATR_RS06270	COG3706	GGDEF domain
ATR_RS06275	COG2181	nitrate reductase activity
ATR_RS06275	COG0247	lactate metabolic process
ATR_RS06280	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ATR_RS06300	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ATR_RS06305	COG1137	ATPase activity
ATR_RS06315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ATR_RS06325	COG0300	oxidoreductase activity
ATR_RS06345	COG0484	heat shock protein binding
ATR_RS06390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ATR_RS06405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ATR_RS06415	COG0784	Response regulator, receiver
ATR_RS06415	COG3437	response regulator, receiver
ATR_RS06420	COG1338	Plays a role in the flagellum-specific transport system
ATR_RS06425	COG0768	penicillin binding
ATR_RS06445	COG2884	Cell division ATP-binding protein ftsE
ATR_RS06450	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ATR_RS06460	COG0564	pseudouridine synthase activity
ATR_RS06465	COG0772	Belongs to the SEDS family
ATR_RS06480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ATR_RS06485	COG3123	guanosine phosphorylase activity
ATR_RS06500	COG5001	Diguanylate cyclase
ATR_RS06500	COG3300	MHYT domain
ATR_RS06510	COG0840	transmembrane signaling receptor activity
ATR_RS06520	COG2217	Heavy metal translocating P-type atpase
ATR_RS06525	COG0640	Transcriptional regulator
ATR_RS06535	COG0840	transmembrane signaling receptor activity
ATR_RS06545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ATR_RS06555	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ATR_RS06565	COG0456	acetyltransferase
ATR_RS06570	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ATR_RS06585	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ATR_RS06590	COG0131	Imidazoleglycerol-phosphate dehydratase
ATR_RS06595	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ATR_RS06605	COG0084	hydrolase, TatD family'
ATR_RS06620	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ATR_RS06625	COG0359	binds to the 23S rRNA
ATR_RS06635	COG0163	prenyltransferase activity
ATR_RS06640	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ATR_RS06645	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ATR_RS06650	COG0124	histidyl-tRNA synthetase
ATR_RS06655	COG1166	arginine decarboxylase activity
ATR_RS06660	COG1045	serine acetyltransferase
ATR_RS06665	COG0730	response to heat
ATR_RS06710	COG1639	'signal transduction protein
ATR_RS06715	COG0012	GTP binding
ATR_RS06720	COG1966	Carbon starvation protein
ATR_RS06735	COG4771	TonB-dependent receptor
ATR_RS06740	COG0673	inositol 2-dehydrogenase activity
ATR_RS06755	COG0305	Participates in initiation and elongation during chromosome replication
ATR_RS06760	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ATR_RS06775	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ATR_RS06780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ATR_RS06790	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ATR_RS06795	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ATR_RS06800	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ATR_RS06810	COG3706	GGDEF domain
ATR_RS06830	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ATR_RS06840	COG0706	membrane insertase activity
ATR_RS06845	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ATR_RS06855	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ATR_RS06860	COG0542	response to heat
ATR_RS06865	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ATR_RS06870	COG1136	(ABC) transporter
ATR_RS06870	COG0577	efflux transmembrane transporter activity
ATR_RS06875	COG0577	efflux transmembrane transporter activity
ATR_RS06875	COG1136	(ABC) transporter
ATR_RS06890	COG0811	peptide transport
ATR_RS06895	COG0848	biopolymer transport protein
ATR_RS06905	COG0732	type I restriction modification DNA specificity domain
ATR_RS06910	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ATR_RS06915	COG3177	Filamentation induced by cAMP protein fic
ATR_RS06930	COG0459	protein refolding
ATR_RS06935	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ATR_RS06945	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ATR_RS06950	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ATR_RS06960	COG0835	chemotaxis
ATR_RS06965	COG1570	exodeoxyribonuclease VII activity
ATR_RS06985	COG1692	metallophosphoesterase
ATR_RS06990	COG5002	protein histidine kinase activity
ATR_RS07000	COG0745	RESPONSE REGULATOR receiver
ATR_RS07005	COG0840	transmembrane signaling receptor activity
ATR_RS07010	COG2081	HI0933 family
ATR_RS07015	COG0642	Histidine kinase
ATR_RS07020	COG0745	RESPONSE REGULATOR receiver
ATR_RS07030	COG1086	Polysaccharide biosynthesis protein
ATR_RS07040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ATR_RS07065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ATR_RS07080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ATR_RS07085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ATR_RS07105	COG1696	Membrane protein involved in D-alanine export
ATR_RS07115	COG0438	transferase activity, transferring glycosyl groups
ATR_RS07125	COG1134	teichoic acid transport
ATR_RS07130	COG1682	transport, permease protein
ATR_RS07135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ATR_RS07150	COG2204	response regulator
ATR_RS07160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ATR_RS07175	COG1968	undecaprenyl-diphosphatase activity
ATR_RS07180	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ATR_RS07190	COG0314	molybdopterin synthase activity
ATR_RS07200	COG0174	glutamine synthetase
ATR_RS07205	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ATR_RS07210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ATR_RS07215	COG0284	orotidine-5'-phosphate decarboxylase activity
ATR_RS07230	COG0582	viral genome integration into host DNA
ATR_RS07265	COG2217	Heavy metal translocating P-type atpase
ATR_RS07270	COG0481	GTPase activity
ATR_RS07290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ATR_RS07295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ATR_RS07305	COG0194	GDP metabolic process
ATR_RS07315	COG1136	(ABC) transporter
ATR_RS07320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ATR_RS07325	COG0052	Belongs to the universal ribosomal protein uS2 family
ATR_RS07330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ATR_RS07345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ATR_RS07350	COG0579	oxidoreductase
ATR_RS07405	COG0745	RESPONSE REGULATOR receiver
ATR_RS07415	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ATR_RS07425	COG2176	DNA-directed DNA polymerase activity
ATR_RS07455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ATR_RS07460	COG0280	phosphate acetyltransferase
ATR_RS07470	COG0616	signal peptide processing
ATR_RS07475	COG0402	S-adenosylhomocysteine deaminase activity
ATR_RS07480	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ATR_RS07485	COG0006	proline dipeptidase activity
ATR_RS07490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ATR_RS07495	COG0482	sulfurtransferase activity
ATR_RS07505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ATR_RS07525	COG0166	Belongs to the GPI family
ATR_RS07545	COG0148	phosphopyruvate hydratase activity
ATR_RS07555	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ATR_RS07570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ATR_RS07575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ATR_RS07580	COG2264	protein methyltransferase activity
ATR_RS07585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ATR_RS07595	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ATR_RS07600	COG0352	thiamine-phosphate diphosphorylase activity
ATR_RS07605	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ATR_RS07610	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ATR_RS07615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ATR_RS07655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ATR_RS07665	COG0133	tryptophan synthase activity
ATR_RS07670	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ATR_RS07685	COG0698	ribose 5-phosphate isomerase
ATR_RS07690	COG0681	Belongs to the peptidase S26 family
ATR_RS07695	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ATR_RS07700	COG1278	Cold shock
ATR_RS07715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ATR_RS07720	COG0085	RNA polymerase activity
ATR_RS07725	COG0222	ribosome binding
ATR_RS07730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ATR_RS07735	COG0081	regulation of translation
ATR_RS07740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ATR_RS07745	COG0250	Participates in transcription elongation, termination and antitermination
ATR_RS07760	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ATR_RS07765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ATR_RS07795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ATR_RS07800	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ATR_RS07805	COG0444	Belongs to the ABC transporter superfamily
ATR_RS07810	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ATR_RS07815	COG2911	Protein conserved in bacteria
ATR_RS07830	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ATR_RS07855	COG0285	dihydrofolate synthase activity
ATR_RS07865	COG0495	leucyl-tRNA aminoacylation
ATR_RS07875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ATR_RS07880	COG1360	Flagellar Motor Protein
ATR_RS07890	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ATR_RS07895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ATR_RS07900	COG1862	Preprotein translocase
ATR_RS07905	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ATR_RS07910	COG0617	tRNA 3'-terminal CCA addition
ATR_RS07910	COG0517	IMP dehydrogenase activity
ATR_RS07910	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ATR_RS07915	COG0668	transmembrane transport
ATR_RS07920	COG0442	prolyl-tRNA aminoacylation
ATR_RS07925	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ATR_RS07930	COG0142	geranyltranstransferase activity
ATR_RS07940	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ATR_RS07945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ATR_RS07950	COG4773	Receptor
ATR_RS07955	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ATR_RS07960	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ATR_RS07985	COG0840	transmembrane signaling receptor activity
ATR_RS07995	COG1971	Probably functions as a manganese efflux pump
ATR_RS08010	COG0811	peptide transport
ATR_RS08025	COG0251	oxidation-reduction process
ATR_RS08030	COG0494	nUDIX hydrolase
ATR_RS08040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ATR_RS08045	COG0586	Pfam SNARE associated Golgi protein
ATR_RS08050	COG0335	large ribosomal subunit rRNA binding
ATR_RS08055	COG0336	Belongs to the RNA methyltransferase TrmD family
ATR_RS08065	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ATR_RS08075	COG3766	membrane
ATR_RS08080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ATR_RS08090	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ATR_RS08100	COG1157	protein secretion by the type III secretion system
ATR_RS08110	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ATR_RS08140	COG0455	bacterial-type flagellum organization
ATR_RS08145	COG1419	protein localization to endoplasmic reticulum
ATR_RS08160	COG3951	Flagellar rod assembly protein muramidase FlgJ
ATR_RS08195	COG1749	Flagellar hook protein flgE
ATR_RS08205	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ATR_RS08215	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ATR_RS08220	COG1766	The M ring may be actively involved in energy transduction
ATR_RS08225	COG1815	bacterial-type flagellum-dependent cell motility
ATR_RS08230	COG4786	Flagellar basal body rod
ATR_RS08240	COG0745	RESPONSE REGULATOR receiver
ATR_RS08260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ATR_RS08265	COG1837	Belongs to the UPF0109 family
ATR_RS08270	COG0228	four-way junction DNA binding
ATR_RS08275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ATR_RS08280	COG0564	pseudouridine synthase activity
ATR_RS08285	COG1519	Transferase
ATR_RS08285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ATR_RS08295	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ATR_RS08300	COG0752	glycyl-tRNA synthetase alpha subunit
ATR_RS08310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ATR_RS08320	COG0826	peptidase U32
ATR_RS08325	COG0840	transmembrane signaling receptor activity
ATR_RS08330	COG0497	DNA recombination
ATR_RS08335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ATR_RS08340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ATR_RS08345	COG0049	tRNA binding
ATR_RS08350	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ATR_RS08355	COG4771	TonB-dependent receptor
ATR_RS08390	COG0542	response to heat
ATR_RS08395	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ATR_RS08400	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ATR_RS08425	COG2030	dehydratase
ATR_RS08465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ATR_RS08470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ATR_RS08475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ATR_RS08490	COG0243	molybdopterin cofactor binding
ATR_RS08495	COG0437	4 iron, 4 sulfur cluster binding
ATR_RS08500	COG0348	domain, Protein
ATR_RS08505	COG3043	anaerobic respiration
ATR_RS08525	COG3287	FIST C domain
ATR_RS08525	COG2200	EAL domain
ATR_RS08525	COG2199	diguanylate cyclase activity
ATR_RS08535	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ATR_RS08540	COG0642	Histidine kinase
ATR_RS08545	COG0745	RESPONSE REGULATOR receiver
ATR_RS08550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ATR_RS08555	COG0191	fructose-bisphosphate aldolase activity
ATR_RS08560	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ATR_RS08565	COG0356	it plays a direct role in the translocation of protons across the membrane
ATR_RS08580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ATR_RS08585	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ATR_RS08595	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ATR_RS08615	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ATR_RS08625	COG0602	queuosine metabolic process
ATR_RS08635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ATR_RS08640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ATR_RS08645	COG0825	malonyl-CoA metabolic process
ATR_RS08650	COG0537	adenosine 5'-monophosphoramidase activity
ATR_RS08655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ATR_RS08660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ATR_RS08660	COG0072	phenylalanine-tRNA ligase activity
ATR_RS08665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ATR_RS08670	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ATR_RS08675	COG1185	polyribonucleotide nucleotidyltransferase activity
ATR_RS08675	COG0539	negative regulation of cytoplasmic translation
ATR_RS08680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ATR_RS08685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ATR_RS08690	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ATR_RS08690	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ATR_RS08695	COG0779	Required for maturation of 30S ribosomal subunits
ATR_RS08700	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ATR_RS08705	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ATR_RS08715	COG0083	homoserine kinase activity
ATR_RS08725	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ATR_RS08740	COG0157	Belongs to the NadC ModD family
ATR_RS08750	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ATR_RS08765	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ATR_RS08770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ATR_RS08775	COG0629	single-stranded DNA binding
ATR_RS08780	COG0360	Binds together with S18 to 16S ribosomal RNA
ATR_RS08795	COG0557	exoribonuclease II activity
ATR_RS08800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ATR_RS08815	COG1309	transcriptional regulator
ATR_RS08845	COG0343	queuine tRNA-ribosyltransferase activity
ATR_RS08850	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ATR_RS08855	COG1393	Belongs to the ArsC family
ATR_RS08860	COG0215	cysteine-tRNA ligase activity
ATR_RS08865	COG0195	Participates in both transcription termination and antitermination
ATR_RS08875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ATR_RS08880	COG2121	Domain of unknown function (DUF374)
ATR_RS08900	COG0443	Heat shock 70 kDa protein
ATR_RS08905	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ATR_RS08910	COG1420	regulation of RNA biosynthetic process
ATR_RS08935	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ATR_RS08940	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ATR_RS08945	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ATR_RS08955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ATR_RS08960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ATR_RS08965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ATR_RS08990	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ATR_RS08995	COG2089	acid synthase
ATR_RS09005	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ATR_RS09010	COG1086	Polysaccharide biosynthesis protein
ATR_RS09020	COG0598	Magnesium transport protein CorA
ATR_RS09025	COG1459	type II secretion system
ATR_RS09045	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ATR_RS09085	COG0512	Glutamine amidotransferase of anthranilate synthase
ATR_RS09125	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ATR_RS09230	COG1840	ABC-type Fe3 transport system, periplasmic component
ATR_RS09235	COG1178	ABC-type Fe3 transport system permease component
ATR_RS09240	COG3842	ATPase activity
ATR_RS09250	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ATR_RS09255	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ATR_RS09265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ATR_RS09270	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ATR_RS09280	COG1222	aaa ATPase
ATR_RS09295	COG0659	secondary active sulfate transmembrane transporter activity
ATR_RS09300	COG1028	Short-chain dehydrogenase reductase Sdr
ATR_RS09305	COG2814	Major facilitator Superfamily
ATR_RS09345	COG0445	tRNA wobble uridine modification
ATR_RS09360	COG1077	Cell shape determining protein MreB Mrl
ATR_RS09365	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ATR_RS09370	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ATR_RS09375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ATR_RS09380	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ATR_RS09385	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ATR_RS09395	COG0733	neurotransmitter:sodium symporter activity
ATR_RS09400	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ATR_RS09430	COG0670	Belongs to the BI1 family
ATR_RS09435	COG0352	thiamine-phosphate diphosphorylase activity
ATR_RS09445	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ATR_RS09450	COG0233	cytoplasmic translational termination
ATR_RS09455	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ATR_RS09470	COG2199	diguanylate cyclase activity
ATR_RS09510	COG0309	Hydrogenase expression formation protein (HypE)
ATR_RS09515	COG0409	Hydrogenase expression formation protein
ATR_RS09520	COG0298	carbon dioxide binding
ATR_RS09525	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ATR_RS09540	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ATR_RS09560	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ATR_RS09565	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ATR_RS09570	COG3022	response to hydroperoxide
ATR_RS09590	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ATR_RS09595	COG1012	belongs to the aldehyde dehydrogenase family
ATR_RS09605	COG0546	phosphoglycolate phosphatase activity
ATR_RS09610	COG0243	molybdopterin cofactor binding
ATR_RS09620	COG0783	Belongs to the Dps family
ATR_RS09625	COG2814	Major facilitator Superfamily
ATR_RS09635	COG2895	sulfate adenylyltransferase (ATP) activity
ATR_RS09640	COG0175	sulfate reduction
ATR_RS09660	COG1959	2 iron, 2 sulfur cluster binding
ATR_RS09685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ATR_RS09690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ATR_RS09700	COG0840	transmembrane signaling receptor activity
ATR_RS09705	COG0840	transmembrane signaling receptor activity
ATR_RS09710	COG2081	HI0933 family
ATR_RS09720	COG1408	metallophosphoesterase
ATR_RS09730	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ATR_RS09735	COG4208	sulfate ABC transporter
ATR_RS09740	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ATR_RS09745	COG0840	transmembrane signaling receptor activity
ATR_RS09765	COG1959	2 iron, 2 sulfur cluster binding
ATR_RS09770	COG1217	gtp-binding protein TYPA
ATR_RS09780	COG0425	Belongs to the sulfur carrier protein TusA family
ATR_RS09785	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ATR_RS09790	COG2860	membrane
ATR_RS09800	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ATR_RS09805	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group