locus-tag	class	description
AVENP_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AVENP_RS00010	COG0592	DNA-directed DNA polymerase activity
AVENP_RS00015	COG0187	DNA topoisomerase II activity
AVENP_RS00020	COG0492	ferredoxin-NADP+ reductase activity
AVENP_RS00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AVENP_RS00035	COG0697	spore germination
AVENP_RS00040	COG1238	metal cluster binding
AVENP_RS00050	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AVENP_RS00065	COG5001	Diguanylate cyclase
AVENP_RS00065	COG5002	protein histidine kinase activity
AVENP_RS00085	COG1053	succinate dehydrogenase
AVENP_RS00090	COG0667	Aldo Keto reductase
AVENP_RS00105	COG4208	sulfate ABC transporter
AVENP_RS00120	COG0500	methyltransferase
AVENP_RS00125	COG1120	ATPase activity
AVENP_RS00150	COG3842	ATPase activity
AVENP_RS00175	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AVENP_RS00180	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AVENP_RS00190	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AVENP_RS00215	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AVENP_RS00220	COG0633	Ferredoxin
AVENP_RS00240	COG0716	FMN binding
AVENP_RS00275	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AVENP_RS00280	COG0840	transmembrane signaling receptor activity
AVENP_RS00285	COG0840	transmembrane signaling receptor activity
AVENP_RS00290	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AVENP_RS00310	COG0426	domain, Protein
AVENP_RS00320	COG0535	radical SAM domain protein
AVENP_RS00335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVENP_RS00365	COG0564	pseudouridine synthase activity
AVENP_RS00370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AVENP_RS00375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AVENP_RS00380	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AVENP_RS00420	COG2954	triphosphatase activity
AVENP_RS00425	COG1151	hydroxylamine reductase activity
AVENP_RS00435	COG0493	'glutamate synthase
AVENP_RS00450	COG0604	alcohol dehydrogenase
AVENP_RS00460	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AVENP_RS00465	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AVENP_RS00490	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AVENP_RS00495	COG0745	RESPONSE REGULATOR receiver
AVENP_RS00500	COG3852	Histidine kinase
AVENP_RS00505	COG1556	Lactate utilization protein
AVENP_RS00510	COG1139	Iron-sulfur cluster binding protein
AVENP_RS00515	COG0247	lactate metabolic process
AVENP_RS00525	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVENP_RS00530	COG0511	ligase activity, forming carbon-carbon bonds
AVENP_RS00535	COG0439	Biotin carboxylase
AVENP_RS00540	COG0513	Belongs to the DEAD box helicase family
AVENP_RS00545	COG0306	phosphate transporter
AVENP_RS00555	COG0367	asparagine synthase
AVENP_RS00565	COG0778	Nitroreductase
AVENP_RS00570	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AVENP_RS00575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AVENP_RS00580	COG1053	succinate dehydrogenase
AVENP_RS00590	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AVENP_RS00600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AVENP_RS00600	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AVENP_RS00605	COG1187	pseudouridine synthase activity
AVENP_RS00610	COG0517	IMP dehydrogenase activity
AVENP_RS00610	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AVENP_RS00620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AVENP_RS00625	COG0107	imidazoleglycerol-phosphate synthase activity
AVENP_RS00640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AVENP_RS00645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVENP_RS00650	COG0724	RNA recognition motif
AVENP_RS00655	COG0745	RESPONSE REGULATOR receiver
AVENP_RS00660	COG0642	Histidine kinase
AVENP_RS00695	COG0534	Mate efflux family protein
AVENP_RS00700	COG0460	homoserine dehydrogenase
AVENP_RS00705	COG0436	Aminotransferase
AVENP_RS00720	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AVENP_RS00725	COG0254	rRNA binding
AVENP_RS00730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AVENP_RS00790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AVENP_RS00820	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AVENP_RS00825	COG2992	FlgJ-related protein
AVENP_RS00830	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AVENP_RS00835	COG0237	dephospho-CoA kinase activity
AVENP_RS00840	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AVENP_RS00845	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AVENP_RS00860	COG2353	YceI-like domain
AVENP_RS00865	COG1846	Transcriptional regulator
AVENP_RS00870	COG1741	Belongs to the pirin family
AVENP_RS00880	COG2353	YceI-like domain
AVENP_RS00885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AVENP_RS00890	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AVENP_RS00895	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AVENP_RS00905	COG0505	Belongs to the CarA family
AVENP_RS00910	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AVENP_RS00920	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AVENP_RS00920	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AVENP_RS00935	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AVENP_RS00940	COG0489	protein tyrosine kinase activity
AVENP_RS00945	COG0140	phosphoribosyl-ATP diphosphatase activity
AVENP_RS00945	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AVENP_RS00965	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVENP_RS00970	COG4310	Domain of unknown function (DUF2172)
AVENP_RS00990	COG1410	methionine synthase
AVENP_RS00990	COG0646	methionine synthase
AVENP_RS00995	COG0697	spore germination
AVENP_RS01005	COG3647	Membrane
AVENP_RS01010	COG1979	alcohol dehydrogenase
AVENP_RS01035	COG1854	S-ribosylhomocysteine lyase activity
AVENP_RS01045	COG1335	isochorismatase
AVENP_RS01060	COG0842	Transport permease protein
AVENP_RS01065	COG0842	Transport permease protein
AVENP_RS01070	COG1131	(ABC) transporter
AVENP_RS01080	COG0840	transmembrane signaling receptor activity
AVENP_RS01085	COG0840	transmembrane signaling receptor activity
AVENP_RS01100	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AVENP_RS01120	COG3180	Ammonia monooxygenase
AVENP_RS01125	COG0288	reversible hydration of carbon dioxide
AVENP_RS01155	COG1013	pyruvate-flavodoxin oxidoreductase activity
AVENP_RS01170	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AVENP_RS01175	COG0546	phosphoglycolate phosphatase activity
AVENP_RS01185	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AVENP_RS01190	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AVENP_RS01195	COG2205	protein histidine kinase activity
AVENP_RS01210	COG0704	Plays a role in the regulation of phosphate uptake
AVENP_RS01215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AVENP_RS01220	COG0581	inorganic phosphate transmembrane transporter activity
AVENP_RS01225	COG0573	inorganic phosphate transmembrane transporter activity
AVENP_RS01230	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AVENP_RS01235	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AVENP_RS01245	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AVENP_RS01250	COG0268	Binds directly to 16S ribosomal RNA
AVENP_RS01255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AVENP_RS01260	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AVENP_RS01265	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AVENP_RS01275	COG0446	pyridine nucleotide-disulphide oxidoreductase
AVENP_RS01285	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AVENP_RS01290	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AVENP_RS01295	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AVENP_RS01300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AVENP_RS01330	COG0575	Belongs to the CDS family
AVENP_RS01335	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AVENP_RS01355	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AVENP_RS01365	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AVENP_RS01365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AVENP_RS01370	COG1324	tolerance protein
AVENP_RS01375	COG2022	thiamine diphosphate biosynthetic process
AVENP_RS01435	COG1271	oxidase subunit
AVENP_RS01445	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AVENP_RS01450	COG0511	ligase activity, forming carbon-carbon bonds
AVENP_RS01470	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AVENP_RS01505	COG2274	protein secretion by the type I secretion system
AVENP_RS01510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVENP_RS01520	COG5002	protein histidine kinase activity
AVENP_RS01525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AVENP_RS01535	COG2084	Dehydrogenase
AVENP_RS01560	COG1346	cytolysis
AVENP_RS01565	COG0640	Transcriptional regulator
AVENP_RS01575	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AVENP_RS01585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AVENP_RS01595	COG1742	UPF0060 membrane protein
AVENP_RS01615	COG1301	dicarboxylic acid transport
AVENP_RS01620	COG0659	secondary active sulfate transmembrane transporter activity
AVENP_RS01635	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AVENP_RS01660	COG0004	ammonium transporteR
AVENP_RS01670	COG0004	ammonium transporteR
AVENP_RS01680	COG0418	dihydroorotase activity
AVENP_RS01685	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AVENP_RS01690	COG1706	bacterial-type flagellum-dependent cell motility
AVENP_RS01725	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AVENP_RS01735	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AVENP_RS01755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AVENP_RS01760	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AVENP_RS01765	COG0601	transmembrane transport
AVENP_RS01775	COG0736	holo-[acyl-carrier-protein] synthase activity
AVENP_RS01780	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AVENP_RS01790	COG0560	Phosphoserine phosphatase
AVENP_RS01795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AVENP_RS01800	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AVENP_RS01805	COG3248	Nucleoside-binding outer membrane protein
AVENP_RS01810	COG1393	Belongs to the ArsC family
AVENP_RS01815	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AVENP_RS01820	COG0343	queuine tRNA-ribosyltransferase activity
AVENP_RS01830	COG0436	Aminotransferase
AVENP_RS01850	COG2861	carbohydrate metabolic process
AVENP_RS01855	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AVENP_RS01860	COG0557	exoribonuclease II activity
AVENP_RS01870	COG0360	Binds together with S18 to 16S ribosomal RNA
AVENP_RS01875	COG0629	single-stranded DNA binding
AVENP_RS01880	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AVENP_RS01885	COG0215	cysteine-tRNA ligase activity
AVENP_RS01890	COG0195	Participates in both transcription termination and antitermination
AVENP_RS01900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AVENP_RS01905	COG2121	Domain of unknown function (DUF374)
AVENP_RS01915	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AVENP_RS01925	COG0288	reversible hydration of carbon dioxide
AVENP_RS01930	COG0156	8-amino-7-oxononanoate synthase activity
AVENP_RS01935	COG0792	nuclease activity
AVENP_RS01970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVENP_RS01980	COG0540	Belongs to the ATCase OTCase family
AVENP_RS01985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AVENP_RS01990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AVENP_RS02005	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AVENP_RS02010	COG1687	branched-chain amino acid
AVENP_RS02015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AVENP_RS02020	COG0416	fatty acid biosynthetic process
AVENP_RS02025	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AVENP_RS02035	COG0105	UTP biosynthetic process
AVENP_RS02045	COG0450	alkyl hydroperoxide reductase
AVENP_RS02050	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AVENP_RS02055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AVENP_RS02060	COG2011	ABC-type metal ion transport system permease component
AVENP_RS02070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AVENP_RS02075	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AVENP_RS02080	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AVENP_RS02090	COG0181	hydroxymethylbilane synthase activity
AVENP_RS02105	COG2828	Protein conserved in bacteria
AVENP_RS02110	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AVENP_RS02120	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AVENP_RS02155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVENP_RS02165	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVENP_RS02180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVENP_RS02185	COG0601	transmembrane transport
AVENP_RS02190	COG4166	transmembrane transport
AVENP_RS02205	COG0514	ATP-dependent DNA helicase (RecQ)
AVENP_RS02215	COG0640	Transcriptional regulator
AVENP_RS02220	COG2217	Heavy metal translocating P-type atpase
AVENP_RS02235	COG1451	nucleotide metabolic process
AVENP_RS02270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AVENP_RS02275	COG1053	succinate dehydrogenase
AVENP_RS02285	COG1007	ATP synthesis coupled electron transport
AVENP_RS02295	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AVENP_RS02300	COG0713	ATP synthesis coupled electron transport
AVENP_RS02305	COG0839	Belongs to the complex I subunit 6 family
AVENP_RS02310	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVENP_RS02315	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AVENP_RS02325	COG0372	Belongs to the citrate synthase family
AVENP_RS02340	COG0649	NAD binding
AVENP_RS02340	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVENP_RS02345	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVENP_RS02350	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVENP_RS02355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AVENP_RS02360	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AVENP_RS02365	COG3610	response to peptide
AVENP_RS02370	COG3610	response to peptide
AVENP_RS02380	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AVENP_RS02385	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AVENP_RS02405	COG1971	Probably functions as a manganese efflux pump
AVENP_RS02420	COG1132	(ABC) transporter
AVENP_RS02430	COG4771	TonB-dependent receptor
AVENP_RS02455	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AVENP_RS02470	COG1280	lysine exporter protein (LysE YggA)
AVENP_RS02475	COG0840	transmembrane signaling receptor activity
AVENP_RS02480	COG1760	l-serine dehydratase
AVENP_RS02485	COG1280	lysine exporter protein (LysE YggA)
AVENP_RS02490	COG1126	abc transporter atp-binding protein
AVENP_RS02495	COG0765	amino acid transport
AVENP_RS02500	COG4597	amino acid ABC transporter
AVENP_RS02505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVENP_RS02510	COG0840	transmembrane signaling receptor activity
AVENP_RS02530	COG3043	anaerobic respiration
AVENP_RS02535	COG0348	domain, Protein
AVENP_RS02540	COG0437	4 iron, 4 sulfur cluster binding
AVENP_RS02545	COG0243	molybdopterin cofactor binding
AVENP_RS02550	COG1648	precorrin-2 dehydrogenase activity
AVENP_RS02550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AVENP_RS02565	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AVENP_RS02570	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AVENP_RS02575	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AVENP_RS02585	COG2404	hydrolase activity, acting on ester bonds
AVENP_RS02590	COG1832	CoA-binding protein
AVENP_RS02595	COG0642	Histidine kinase
AVENP_RS02600	COG0745	RESPONSE REGULATOR receiver
AVENP_RS02605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AVENP_RS02610	COG0191	fructose-bisphosphate aldolase activity
AVENP_RS02615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AVENP_RS02635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVENP_RS02670	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AVENP_RS02685	COG0535	radical SAM domain protein
AVENP_RS02690	COG3842	ATPase activity
AVENP_RS02700	COG1177	transmembrane transport
AVENP_RS02705	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AVENP_RS02710	COG0745	RESPONSE REGULATOR receiver
AVENP_RS02715	COG0784	Response regulator, receiver
AVENP_RS02715	COG2205	protein histidine kinase activity
AVENP_RS02730	COG1278	Cold shock
AVENP_RS02735	COG0848	biopolymer transport protein
AVENP_RS02740	COG0811	peptide transport
AVENP_RS02750	COG4191	Histidine kinase
AVENP_RS02765	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AVENP_RS02775	COG0142	geranyltranstransferase activity
AVENP_RS02780	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AVENP_RS02785	COG0442	prolyl-tRNA aminoacylation
AVENP_RS02790	COG0668	transmembrane transport
AVENP_RS02795	COG0617	tRNA 3'-terminal CCA addition
AVENP_RS02810	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AVENP_RS02815	COG1862	Preprotein translocase
AVENP_RS02820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AVENP_RS02825	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AVENP_RS02845	COG0495	leucyl-tRNA aminoacylation
AVENP_RS02855	COG0285	dihydrofolate synthase activity
AVENP_RS02870	COG0848	biopolymer transport protein
AVENP_RS02875	COG0811	peptide transport
AVENP_RS02895	COG1136	(ABC) transporter
AVENP_RS02895	COG0577	efflux transmembrane transporter activity
AVENP_RS02900	COG1136	(ABC) transporter
AVENP_RS02900	COG0577	efflux transmembrane transporter activity
AVENP_RS02905	COG0666	response to abiotic stimulus
AVENP_RS02945	COG0735	belongs to the Fur family
AVENP_RS02985	COG0114	fumarate hydratase activity
AVENP_RS02995	COG3852	Histidine kinase
AVENP_RS03000	COG0745	RESPONSE REGULATOR receiver
AVENP_RS03005	COG0604	alcohol dehydrogenase
AVENP_RS03010	COG1733	regulation of RNA biosynthetic process
AVENP_RS03015	COG0840	transmembrane signaling receptor activity
AVENP_RS03070	COG4774	siderophore transport
AVENP_RS03075	COG3128	pkhd-type hydroxylase
AVENP_RS03110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVENP_RS03115	COG0418	dihydroorotase activity
AVENP_RS03120	COG0720	synthase
AVENP_RS03165	COG0737	Belongs to the 5'-nucleotidase family
AVENP_RS03180	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AVENP_RS03225	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AVENP_RS03245	COG2203	Gaf domain
AVENP_RS03245	COG4251	negative regulation of phosphorylation
AVENP_RS03245	COG3706	GGDEF domain
AVENP_RS03245	COG5001	Diguanylate cyclase
AVENP_RS03255	COG0745	RESPONSE REGULATOR receiver
AVENP_RS03260	COG0642	Histidine kinase
AVENP_RS03265	COG2081	HI0933 family
AVENP_RS03270	COG0840	transmembrane signaling receptor activity
AVENP_RS03285	COG5000	phosphorelay sensor kinase activity
AVENP_RS03290	COG1692	metallophosphoesterase
AVENP_RS03310	COG2226	methyltransferase
AVENP_RS03315	COG1570	exodeoxyribonuclease VII activity
AVENP_RS03320	COG0835	chemotaxis
AVENP_RS03340	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AVENP_RS03345	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AVENP_RS03355	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AVENP_RS03360	COG0459	protein refolding
AVENP_RS03370	COG0745	RESPONSE REGULATOR receiver
AVENP_RS03375	COG1408	metallophosphoesterase
AVENP_RS03385	COG2353	YceI-like domain
AVENP_RS03400	COG0577	efflux transmembrane transporter activity
AVENP_RS03400	COG1136	(ABC) transporter
AVENP_RS03415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AVENP_RS03430	COG2962	Rard protein
AVENP_RS03435	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AVENP_RS03440	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AVENP_RS03450	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AVENP_RS03460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AVENP_RS03465	COG2264	protein methyltransferase activity
AVENP_RS03470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVENP_RS03490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVENP_RS03495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AVENP_RS03520	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AVENP_RS03580	COG1132	(ABC) transporter
AVENP_RS03595	COG3706	GGDEF domain
AVENP_RS03600	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AVENP_RS03605	COG1090	epimerase
AVENP_RS03610	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AVENP_RS03620	COG0840	transmembrane signaling receptor activity
AVENP_RS03645	COG0481	GTPase activity
AVENP_RS03660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AVENP_RS03670	COG0482	sulfurtransferase activity
AVENP_RS03680	COG0482	sulfurtransferase activity
AVENP_RS03685	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AVENP_RS03690	COG0006	proline dipeptidase activity
AVENP_RS03695	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AVENP_RS03700	COG0402	S-adenosylhomocysteine deaminase activity
AVENP_RS03705	COG0616	signal peptide processing
AVENP_RS03715	COG0280	phosphate acetyltransferase
AVENP_RS03720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AVENP_RS03725	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AVENP_RS03730	COG2176	DNA-directed DNA polymerase activity
AVENP_RS03750	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVENP_RS03770	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVENP_RS03780	COG0745	RESPONSE REGULATOR receiver
AVENP_RS03785	COG5002	protein histidine kinase activity
AVENP_RS03830	COG1546	Belongs to the CinA family
AVENP_RS03830	COG1058	Belongs to the CinA family
AVENP_RS03835	COG0579	oxidoreductase
AVENP_RS03840	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AVENP_RS03855	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AVENP_RS03865	COG0052	Belongs to the universal ribosomal protein uS2 family
AVENP_RS03870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AVENP_RS03875	COG1136	(ABC) transporter
AVENP_RS03885	COG0194	GDP metabolic process
AVENP_RS03890	COG5001	Diguanylate cyclase
AVENP_RS03890	COG5002	protein histidine kinase activity
AVENP_RS03895	COG2217	Heavy metal translocating P-type atpase
AVENP_RS03910	COG4608	Belongs to the ABC transporter superfamily
AVENP_RS03915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AVENP_RS03930	COG1355	regulation of microtubule-based process
AVENP_RS03935	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AVENP_RS03940	COG1121	(ABC) transporter
AVENP_RS03945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AVENP_RS03955	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AVENP_RS03960	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AVENP_RS03970	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AVENP_RS03980	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AVENP_RS03990	COG0004	ammonium transporteR
AVENP_RS04000	COG0210	DNA helicase
AVENP_RS04005	COG0569	domain protein
AVENP_RS04005	COG0475	glutathione-regulated potassium exporter activity
AVENP_RS04010	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AVENP_RS04035	COG3258	Cytochrome c
AVENP_RS04070	COG0693	protein deglycase activity
AVENP_RS04085	COG0525	valine-tRNA ligase activity
AVENP_RS04100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AVENP_RS04115	COG1047	Peptidyl-prolyl cis-trans
AVENP_RS04150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVENP_RS04165	COG2814	Major facilitator Superfamily
AVENP_RS04170	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AVENP_RS04190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AVENP_RS04200	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVENP_RS04205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AVENP_RS04245	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AVENP_RS04250	COG1309	transcriptional regulator
AVENP_RS04295	COG0439	Biotin carboxylase
AVENP_RS04305	COG3177	Filamentation induced by cAMP protein fic
AVENP_RS04320	COG2166	iron-sulfur cluster assembly
AVENP_RS04325	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AVENP_RS04335	COG0396	ATPase activity
AVENP_RS04340	COG0719	Fe-S assembly protein
AVENP_RS04350	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AVENP_RS04350	COG2906	2 iron, 2 sulfur cluster binding
AVENP_RS04350	COG0822	iron-sulfur transferase activity
AVENP_RS04355	COG1280	lysine exporter protein (LysE YggA)
AVENP_RS04365	COG2239	Acts as a magnesium transporter
AVENP_RS04370	COG0165	Argininosuccinate lyase
AVENP_RS04375	COG0784	Response regulator, receiver
AVENP_RS04375	COG0835	chemotaxis
AVENP_RS04380	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AVENP_RS04385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AVENP_RS04390	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AVENP_RS04405	COG0556	nucleotide-excision repair
AVENP_RS04425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AVENP_RS04460	COG0698	ribose 5-phosphate isomerase
AVENP_RS04465	COG0681	Belongs to the peptidase S26 family
AVENP_RS04470	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AVENP_RS04475	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AVENP_RS04480	COG0193	aminoacyl-tRNA hydrolase activity
AVENP_RS04495	COG0860	N-Acetylmuramoyl-L-alanine amidase
AVENP_RS04505	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AVENP_RS04510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AVENP_RS04520	COG0528	UMP kinase activity
AVENP_RS04530	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AVENP_RS04535	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AVENP_RS04540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AVENP_RS04550	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AVENP_RS04555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AVENP_RS04570	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AVENP_RS04575	COG0305	Participates in initiation and elongation during chromosome replication
AVENP_RS04585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AVENP_RS04595	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AVENP_RS04600	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AVENP_RS04605	COG1088	dTDP-glucose 4,6-dehydratase activity
AVENP_RS04610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AVENP_RS04615	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AVENP_RS04700	COG1063	alcohol dehydrogenase
AVENP_RS04720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AVENP_RS04725	COG1086	Polysaccharide biosynthesis protein
AVENP_RS04735	COG1793	dna ligase
AVENP_RS04740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AVENP_RS04745	COG0133	tryptophan synthase activity
AVENP_RS04755	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AVENP_RS04765	COG1979	alcohol dehydrogenase
AVENP_RS04770	COG0667	Aldo Keto reductase
AVENP_RS04775	COG0702	epimerase
AVENP_RS04780	COG0500	methyltransferase
AVENP_RS04785	COG2207	Transcriptional regulator
AVENP_RS04800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AVENP_RS04805	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AVENP_RS04815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVENP_RS04855	COG0012	GTP binding
AVENP_RS04875	COG3123	guanosine phosphorylase activity
AVENP_RS04885	COG3278	Belongs to the heme-copper respiratory oxidase family
AVENP_RS04905	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AVENP_RS04910	COG0840	transmembrane signaling receptor activity
AVENP_RS04915	COG0840	transmembrane signaling receptor activity
AVENP_RS04920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVENP_RS04950	COG0583	DNA-binding transcription factor activity
AVENP_RS04955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AVENP_RS04960	COG0066	3-isopropylmalate dehydratase activity
AVENP_RS04970	COG4974	Belongs to the 'phage' integrase family
AVENP_RS05140	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AVENP_RS05145	COG0585	pseudouridine synthase activity
AVENP_RS05155	COG0840	transmembrane signaling receptor activity
AVENP_RS05160	COG0632	four-way junction helicase activity
AVENP_RS05165	COG1181	Belongs to the D-alanine--D-alanine ligase family
AVENP_RS05175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AVENP_RS05190	COG0840	transmembrane signaling receptor activity
AVENP_RS05195	COG0840	transmembrane signaling receptor activity
AVENP_RS05200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVENP_RS05205	COG0051	transcription antitermination factor activity, RNA binding
AVENP_RS05210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AVENP_RS05215	COG0088	Forms part of the polypeptide exit tunnel
AVENP_RS05220	COG0089	rRNA binding
AVENP_RS05225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AVENP_RS05230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AVENP_RS05235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AVENP_RS05240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AVENP_RS05245	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AVENP_RS05250	COG0255	Belongs to the universal ribosomal protein uL29 family
AVENP_RS05255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AVENP_RS05260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AVENP_RS05265	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AVENP_RS05270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AVENP_RS05275	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AVENP_RS05280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AVENP_RS05285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AVENP_RS05290	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AVENP_RS05295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AVENP_RS05300	COG0200	Binds to the 23S rRNA
AVENP_RS05305	COG0201	protein transport
AVENP_RS05310	COG0024	Methionine aminopeptidase
AVENP_RS05315	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AVENP_RS05325	COG1573	uracil-dna glycosylase
AVENP_RS05335	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AVENP_RS05350	COG1032	radical SAM domain protein
AVENP_RS05355	COG1280	lysine exporter protein (LysE YggA)
AVENP_RS05365	COG0563	adenylate kinase activity
AVENP_RS05380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AVENP_RS05385	COG0322	excinuclease ABC activity
AVENP_RS05400	COG3201	nicotinamide mononucleotide transporter
AVENP_RS05405	COG0386	Belongs to the glutathione peroxidase family
AVENP_RS05410	COG0840	transmembrane signaling receptor activity
AVENP_RS05415	COG0840	transmembrane signaling receptor activity
AVENP_RS05435	COG1360	Flagellar Motor Protein
AVENP_RS05440	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AVENP_RS05445	COG0745	RESPONSE REGULATOR receiver
AVENP_RS05450	COG0745	RESPONSE REGULATOR receiver
AVENP_RS05455	COG2205	protein histidine kinase activity
AVENP_RS05455	COG0784	Response regulator, receiver
AVENP_RS05470	COG0581	inorganic phosphate transmembrane transporter activity
AVENP_RS05475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AVENP_RS05505	COG4773	Receptor
AVENP_RS05535	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AVENP_RS05560	COG0829	nickel cation binding
AVENP_RS05565	COG2252	PERMEase
AVENP_RS05575	COG0765	amino acid transport
AVENP_RS05580	COG0765	amino acid transport
AVENP_RS05600	COG4266	Belongs to the allantoicase family
AVENP_RS05610	COG0832	Belongs to the urease beta subunit family
AVENP_RS05610	COG0831	urea catabolic process
AVENP_RS05615	COG0804	urea catabolic process
AVENP_RS05620	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AVENP_RS05630	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AVENP_RS05635	COG0745	RESPONSE REGULATOR receiver
AVENP_RS05660	COG0840	transmembrane signaling receptor activity
AVENP_RS05670	COG1309	transcriptional regulator
AVENP_RS05700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVENP_RS05705	COG4565	transcriptional regulatory protein
AVENP_RS05735	COG3383	formate dehydrogenase (NAD+) activity
AVENP_RS05735	COG0243	molybdopterin cofactor binding
AVENP_RS05740	COG0437	4 iron, 4 sulfur cluster binding
AVENP_RS05750	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AVENP_RS05770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AVENP_RS05785	COG3179	chitinase
AVENP_RS05800	COG0251	oxidation-reduction process
AVENP_RS05805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVENP_RS05810	COG1115	amino acid carrier protein
AVENP_RS05815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AVENP_RS05820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVENP_RS05825	COG0328	RNA-DNA hybrid ribonuclease activity
AVENP_RS05835	COG0840	transmembrane signaling receptor activity
AVENP_RS05870	COG0784	Response regulator, receiver
AVENP_RS05870	COG3437	response regulator, receiver
AVENP_RS05885	COG1944	ATP diphosphatase activity
AVENP_RS05905	COG0513	Belongs to the DEAD box helicase family
AVENP_RS05930	COG2258	MOSC domain
AVENP_RS05935	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVENP_RS05940	COG0519	Catalyzes the synthesis of GMP from XMP
AVENP_RS05945	COG2169	Transcriptional regulator
AVENP_RS05945	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AVENP_RS05950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AVENP_RS05960	COG0475	glutathione-regulated potassium exporter activity
AVENP_RS05960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AVENP_RS05985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AVENP_RS05995	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AVENP_RS06010	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AVENP_RS06035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVENP_RS06040	COG1611	Belongs to the LOG family
AVENP_RS06060	COG0217	transcriptional regulatory protein
AVENP_RS06080	COG1960	acyl-CoA dehydrogenase activity
AVENP_RS06085	COG1024	Enoyl-CoA hydratase
AVENP_RS06085	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVENP_RS06090	COG0183	Belongs to the thiolase family
AVENP_RS06095	COG1022	Amp-dependent synthetase and ligase
AVENP_RS06110	COG0242	peptide deformylase activity
AVENP_RS06120	COG1049	propionate catabolic process, 2-methylcitrate cycle
AVENP_RS06125	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AVENP_RS06130	COG1301	dicarboxylic acid transport
AVENP_RS06135	COG0697	spore germination
AVENP_RS06140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVENP_RS06155	COG2095	MarC family integral membrane protein
AVENP_RS06190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AVENP_RS06195	COG1121	(ABC) transporter
AVENP_RS06225	COG2199	diguanylate cyclase activity
AVENP_RS06225	COG2203	Gaf domain
AVENP_RS06240	COG3259	Nickel-dependent hydrogenase
AVENP_RS06245	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AVENP_RS06250	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AVENP_RS06295	COG4774	siderophore transport
AVENP_RS06300	COG2207	Transcriptional regulator
AVENP_RS06305	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AVENP_RS06310	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AVENP_RS06315	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AVENP_RS06390	COG0301	tRNA thio-modification
AVENP_RS06390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AVENP_RS06410	COG2056	Na+-H+ antiporter family
AVENP_RS06425	COG0596	Alpha beta hydrolase
AVENP_RS06435	COG0384	phenazine biosynthesis protein PhzF
AVENP_RS06445	COG2814	Major facilitator Superfamily
AVENP_RS06460	COG2354	Protein conserved in bacteria
AVENP_RS06470	COG2081	HI0933 family
AVENP_RS06480	COG0840	transmembrane signaling receptor activity
AVENP_RS06490	COG0310	cobalt ion transport
AVENP_RS06520	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AVENP_RS06530	COG4804	nuclease activity
AVENP_RS06550	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AVENP_RS06555	COG0298	carbon dioxide binding
AVENP_RS06565	COG2084	Dehydrogenase
AVENP_RS06575	COG1401	restriction endodeoxyribonuclease activity
AVENP_RS06585	COG0309	Hydrogenase expression formation protein (HypE)
AVENP_RS06615	COG0410	ABC transporter
AVENP_RS06620	COG3706	GGDEF domain
AVENP_RS06645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AVENP_RS06650	COG2171	N-acyltransferase activity
AVENP_RS06655	COG0488	(ABC) transporter
AVENP_RS06665	COG1671	Belongs to the UPF0178 family
AVENP_RS06680	COG2884	Cell division ATP-binding protein ftsE
AVENP_RS06685	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AVENP_RS06695	COG0564	pseudouridine synthase activity
AVENP_RS06700	COG0772	Belongs to the SEDS family
AVENP_RS06715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AVENP_RS06720	COG3123	guanosine phosphorylase activity
AVENP_RS06740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AVENP_RS06745	COG0066	3-isopropylmalate dehydratase activity
AVENP_RS06750	COG0473	3-isopropylmalate dehydrogenase activity
AVENP_RS06765	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AVENP_RS06770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AVENP_RS06775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AVENP_RS06780	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AVENP_RS06785	COG0202	RNA polymerase activity
AVENP_RS06790	COG0203	ribosomal protein L17
AVENP_RS06795	COG0154	amidase activity
AVENP_RS06800	COG0517	IMP dehydrogenase activity
AVENP_RS06800	COG0516	GMP reductase activity
AVENP_RS06810	COG2827	Endonuclease containing a URI domain
AVENP_RS06820	COG1047	Peptidyl-prolyl cis-trans
AVENP_RS06825	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AVENP_RS06830	COG2040	homocysteine
AVENP_RS06835	COG1280	lysine exporter protein (LysE YggA)
AVENP_RS06870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AVENP_RS06870	COG0189	ligase activity
AVENP_RS06890	COG1620	l-lactate permease
AVENP_RS06900	COG0484	heat shock protein binding
AVENP_RS06915	COG1472	Belongs to the glycosyl hydrolase 3 family
AVENP_RS06920	COG0628	permease
AVENP_RS06925	COG1132	(ABC) transporter
AVENP_RS06945	COG0745	RESPONSE REGULATOR receiver
AVENP_RS06950	COG0642	Histidine kinase
AVENP_RS06965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AVENP_RS06995	COG1373	ATPase (AAA superfamily
AVENP_RS07010	COG3279	Response regulator of the LytR AlgR family
AVENP_RS07020	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AVENP_RS07025	COG0513	Belongs to the DEAD box helicase family
AVENP_RS07030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AVENP_RS07040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AVENP_RS07045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVENP_RS07055	COG0521	Mo-molybdopterin cofactor biosynthetic process
AVENP_RS07060	COG0471	metal ion transport
AVENP_RS07070	COG2200	EAL domain
AVENP_RS07070	COG2199	diguanylate cyclase activity
AVENP_RS07070	COG3287	FIST C domain
AVENP_RS07080	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AVENP_RS07095	COG3040	lipid binding
AVENP_RS07105	COG4221	oxidoreductase activity
AVENP_RS07115	COG0488	(ABC) transporter
AVENP_RS07120	COG1607	acyl-coa hydrolase
AVENP_RS07125	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AVENP_RS07160	COG4206	TonB-dependent receptor
AVENP_RS07165	COG4607	ABC-type enterochelin transport system periplasmic component
AVENP_RS07175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVENP_RS07180	COG0588	phosphoglycerate mutase activity
AVENP_RS07185	COG1797	cobyrinic acid a,c-diamide synthase activity
AVENP_RS07205	COG1193	negative regulation of DNA recombination
AVENP_RS07225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AVENP_RS07260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AVENP_RS07265	COG0789	Transcriptional regulator
AVENP_RS07270	COG0484	heat shock protein binding
AVENP_RS07285	COG2201	protein-glutamate methylesterase activity
AVENP_RS07305	COG1376	ErfK ybiS ycfS ynhG family protein
AVENP_RS07305	COG1388	LysM domain
AVENP_RS07315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVENP_RS07330	COG1696	Membrane protein involved in D-alanine export
AVENP_RS07335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVENP_RS07345	COG0776	regulation of translation
AVENP_RS07355	COG0275	rRNA processing
AVENP_RS07395	COG4865	methylaspartate mutase activity
AVENP_RS07410	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AVENP_RS07420	COG4591	ABC-type transport system involved in lipoprotein release permease component
AVENP_RS07425	COG0653	protein targeting
AVENP_RS07440	COG0582	viral genome integration into host DNA
AVENP_RS07540	COG2195	Cleaves the N-terminal amino acid of tripeptides
AVENP_RS07555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AVENP_RS07555	COG1333	cytochrome c biogenesis protein
AVENP_RS07560	COG0500	methyltransferase
AVENP_RS07565	COG2203	Gaf domain
AVENP_RS07565	COG5001	Diguanylate cyclase
AVENP_RS07565	COG3706	GGDEF domain
AVENP_RS07565	COG4251	negative regulation of phosphorylation
AVENP_RS07570	COG5001	Diguanylate cyclase
AVENP_RS07575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVENP_RS07595	COG0133	tryptophan synthase activity
AVENP_RS07605	COG0484	heat shock protein binding
AVENP_RS07610	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AVENP_RS07620	COG0840	transmembrane signaling receptor activity
AVENP_RS07635	COG0745	RESPONSE REGULATOR receiver
AVENP_RS07640	COG4191	Histidine kinase
AVENP_RS07645	COG2205	protein histidine kinase activity
AVENP_RS07650	COG0745	RESPONSE REGULATOR receiver
AVENP_RS07655	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AVENP_RS07660	COG0569	domain protein
AVENP_RS07685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AVENP_RS07690	COG0137	argininosuccinate synthase activity
AVENP_RS07715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AVENP_RS07720	COG0802	atpase or kinase
AVENP_RS07725	COG1137	ATPase activity
AVENP_RS07730	COG3706	GGDEF domain
AVENP_RS07735	COG2199	diguanylate cyclase activity
AVENP_RS07735	COG2200	EAL domain
AVENP_RS07735	COG3287	FIST C domain
AVENP_RS07740	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AVENP_RS07745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AVENP_RS07745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AVENP_RS07765	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AVENP_RS07780	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AVENP_RS07810	COG0733	neurotransmitter:sodium symporter activity
AVENP_RS07825	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AVENP_RS07830	COG0805	protein transport
AVENP_RS07835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AVENP_RS07840	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AVENP_RS07860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AVENP_RS07865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AVENP_RS07870	COG1663	tetraacyldisaccharide 4'-kinase activity
AVENP_RS07880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AVENP_RS07885	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AVENP_RS07890	COG1328	CTP reductase activity
AVENP_RS07890	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AVENP_RS07905	COG0745	RESPONSE REGULATOR receiver
AVENP_RS07910	COG0840	transmembrane signaling receptor activity
AVENP_RS07915	COG0113	porphobilinogen synthase activity
AVENP_RS07920	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVENP_RS07925	COG0357	Ribosomal RNA small subunit methyltransferase G
AVENP_RS07980	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AVENP_RS07985	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AVENP_RS07990	COG0511	ligase activity, forming carbon-carbon bonds
AVENP_RS08010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVENP_RS08010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVENP_RS08020	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AVENP_RS08050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVENP_RS08055	COG0612	Peptidase, M16
AVENP_RS08060	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AVENP_RS08065	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVENP_RS08070	COG0287	Prephenate dehydrogenase
AVENP_RS08075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AVENP_RS08090	COG0527	aspartate kinase activity
AVENP_RS08095	COG0494	nUDIX hydrolase
AVENP_RS08100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AVENP_RS08105	COG2890	protein-(glutamine-N5) methyltransferase activity
AVENP_RS08110	COG0339	signal peptide processing
AVENP_RS08130	COG0582	viral genome integration into host DNA
AVENP_RS08205	COG1450	Type ii and iii secretion system protein
AVENP_RS08240	COG2201	protein-glutamate methylesterase activity
AVENP_RS08245	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AVENP_RS08250	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AVENP_RS08255	COG2198	Histidine kinase
AVENP_RS08255	COG0643	Histidine kinase
AVENP_RS08265	COG1185	polyribonucleotide nucleotidyltransferase activity
AVENP_RS08275	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AVENP_RS08295	COG0659	secondary active sulfate transmembrane transporter activity
AVENP_RS08300	COG1160	GTP binding
AVENP_RS08315	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AVENP_RS08320	COG1749	Flagellar hook protein flgE
AVENP_RS08335	COG1749	Flagellar hook protein flgE
AVENP_RS08345	COG0642	Histidine kinase
AVENP_RS08350	COG0745	RESPONSE REGULATOR receiver
AVENP_RS08355	COG1674	ftsk spoiiie
AVENP_RS08355	COG1196	nuclear chromosome segregation
AVENP_RS08360	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVENP_RS08365	COG0440	acetolactate synthase activity
AVENP_RS08370	COG0028	Belongs to the TPP enzyme family
AVENP_RS08395	COG0848	biopolymer transport protein
AVENP_RS08400	COG0811	peptide transport
AVENP_RS08415	COG0840	transmembrane signaling receptor activity
AVENP_RS08450	COG0419	ATPase involved in DNA repair
AVENP_RS08460	COG2207	Transcriptional regulator
AVENP_RS08475	COG0450	alkyl hydroperoxide reductase
AVENP_RS08490	COG1342	Belongs to the UPF0251 family
AVENP_RS08500	COG1271	oxidase subunit
AVENP_RS08520	COG0330	HflC and HflK could
AVENP_RS08525	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AVENP_RS08535	COG0745	RESPONSE REGULATOR receiver
AVENP_RS08540	COG0840	transmembrane signaling receptor activity
AVENP_RS08555	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AVENP_RS08560	COG0788	formyltetrahydrofolate deformylase activity
AVENP_RS08565	COG0281	malic enzyme
AVENP_RS08565	COG0280	phosphate acetyltransferase
AVENP_RS08570	COG1027	Aspartate ammonia-lyase
AVENP_RS08575	COG3852	Histidine kinase
AVENP_RS08580	COG0745	RESPONSE REGULATOR receiver
AVENP_RS08595	COG4106	trans-aconitate 2-methyltransferase activity
AVENP_RS08600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AVENP_RS08625	COG0754	glutathionylspermidine amidase activity
AVENP_RS08640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AVENP_RS08660	COG4251	negative regulation of phosphorylation
AVENP_RS08660	COG5001	Diguanylate cyclase
AVENP_RS08660	COG2203	Gaf domain
AVENP_RS08660	COG3706	GGDEF domain
AVENP_RS08680	COG0037	tRNA processing
AVENP_RS08700	COG0701	Predicted permease
AVENP_RS08705	COG1322	Protein conserved in bacteria
AVENP_RS08710	COG0501	Belongs to the peptidase M48B family
AVENP_RS08720	COG0824	Thioesterase
AVENP_RS08735	COG0840	transmembrane signaling receptor activity
AVENP_RS08740	COG0667	Aldo Keto reductase
AVENP_RS08805	COG1733	regulation of RNA biosynthetic process
AVENP_RS08810	COG2249	NAD(P)H dehydrogenase (quinone) activity
AVENP_RS08815	COG3046	protein related to deoxyribodipyrimidine photolyase
AVENP_RS08820	COG3040	lipid binding
AVENP_RS08835	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AVENP_RS08845	COG2207	Transcriptional regulator
AVENP_RS08845	COG4753	response regulator
AVENP_RS08885	COG3501	Rhs element vgr protein
AVENP_RS08895	COG0778	Nitroreductase
AVENP_RS08915	COG0778	Nitroreductase
AVENP_RS08920	COG2249	NAD(P)H dehydrogenase (quinone) activity
AVENP_RS08925	COG1733	regulation of RNA biosynthetic process
AVENP_RS08945	COG2855	membrane
AVENP_RS08950	COG0583	DNA-binding transcription factor activity
AVENP_RS08960	COG3706	GGDEF domain
AVENP_RS08985	COG2249	NAD(P)H dehydrogenase (quinone) activity
AVENP_RS08990	COG1733	regulation of RNA biosynthetic process
AVENP_RS09015	COG2824	Alkylphosphonate utilization operon protein PhnA
AVENP_RS09030	COG0488	(ABC) transporter
AVENP_RS09040	COG0596	Alpha beta hydrolase
AVENP_RS09050	COG0077	Prephenate dehydratase
AVENP_RS09050	COG1605	Chorismate mutase
AVENP_RS09060	COG1119	ATPase activity
AVENP_RS09065	COG1696	Membrane protein involved in D-alanine export
AVENP_RS09080	COG2192	nodulation
AVENP_RS09100	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AVENP_RS09110	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AVENP_RS09120	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AVENP_RS09135	COG2003	Belongs to the UPF0758 family
AVENP_RS09140	COG1722	exodeoxyribonuclease VII activity
AVENP_RS09145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AVENP_RS09170	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AVENP_RS09175	COG0849	cell division
AVENP_RS09220	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AVENP_RS09230	COG0768	penicillin binding
AVENP_RS09240	COG5000	phosphorelay sensor kinase activity
AVENP_RS09245	COG2897	thiosulfate sulfurtransferase activity
AVENP_RS09285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVENP_RS09300	COG0456	acetyltransferase
AVENP_RS09305	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AVENP_RS09320	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AVENP_RS09325	COG0131	Imidazoleglycerol-phosphate dehydratase
AVENP_RS09330	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AVENP_RS09340	COG0084	hydrolase, TatD family'
AVENP_RS09350	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AVENP_RS09355	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AVENP_RS09360	COG0359	binds to the 23S rRNA
AVENP_RS09370	COG0163	prenyltransferase activity
AVENP_RS09375	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AVENP_RS09380	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AVENP_RS09385	COG0124	histidyl-tRNA synthetase
AVENP_RS09390	COG1166	arginine decarboxylase activity
AVENP_RS09395	COG1045	serine acetyltransferase
AVENP_RS09405	COG0513	Belongs to the DEAD box helicase family
AVENP_RS09420	COG1309	transcriptional regulator
AVENP_RS09435	COG1012	belongs to the aldehyde dehydrogenase family
AVENP_RS09440	COG1881	PFAM PEBP family protein
AVENP_RS09445	COG2207	Transcriptional regulator
AVENP_RS09445	COG1609	Transcriptional regulator
AVENP_RS09460	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AVENP_RS09470	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AVENP_RS09485	COG0475	glutathione-regulated potassium exporter activity
AVENP_RS09485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AVENP_RS09490	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AVENP_RS09495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AVENP_RS09535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVENP_RS09540	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVENP_RS09545	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AVENP_RS09550	COG0095	Lipoate-protein ligase
AVENP_RS09555	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AVENP_RS09560	COG0039	L-malate dehydrogenase activity
AVENP_RS09565	COG0628	permease
AVENP_RS09580	COG2989	Protein conserved in bacteria
AVENP_RS09585	COG1253	flavin adenine dinucleotide binding
AVENP_RS09615	COG1028	Short-chain dehydrogenase reductase Sdr
AVENP_RS09620	COG2807	transmembrane transport
AVENP_RS09625	COG2186	Transcriptional regulator
AVENP_RS09630	COG2223	nitrite transmembrane transporter activity
AVENP_RS09635	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AVENP_RS09645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AVENP_RS09660	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AVENP_RS09685	COG0564	pseudouridine synthase activity
AVENP_RS09700	COG1280	lysine exporter protein (LysE YggA)
AVENP_RS09705	COG1489	DNA binding
AVENP_RS09730	COG2814	Major facilitator Superfamily
AVENP_RS09740	COG1538	Outer membrane efflux protein
AVENP_RS09790	COG1187	pseudouridine synthase activity
AVENP_RS09810	COG4716	Myosin-crossreactive antigen
AVENP_RS09840	COG0454	-acetyltransferase
AVENP_RS09855	COG0519	Catalyzes the synthesis of GMP from XMP
AVENP_RS09855	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AVENP_RS09860	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AVENP_RS09865	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AVENP_RS09890	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AVENP_RS09895	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AVENP_RS09945	COG0642	Histidine kinase
AVENP_RS09960	COG3258	Cytochrome c
AVENP_RS09970	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AVENP_RS09980	COG0438	transferase activity, transferring glycosyl groups
AVENP_RS09985	COG0463	Glycosyl transferase, family 2
AVENP_RS10015	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AVENP_RS10020	COG1028	Short-chain dehydrogenase reductase Sdr
AVENP_RS10025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVENP_RS10035	COG2089	acid synthase
AVENP_RS10040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AVENP_RS10050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVENP_RS10060	COG0662	Cupin 2, conserved barrel domain protein
AVENP_RS10060	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AVENP_RS10075	COG0529	Catalyzes the synthesis of activated sulfate
AVENP_RS10120	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AVENP_RS10125	COG0300	oxidoreductase activity
AVENP_RS10130	COG1757	Na H antiporter
AVENP_RS10135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVENP_RS10140	COG0742	ribosomal rna small subunit methyltransferase
AVENP_RS10145	COG1418	mRNA catabolic process
AVENP_RS10155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AVENP_RS10160	COG0552	protein localization to endoplasmic reticulum
AVENP_RS10205	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AVENP_RS10210	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AVENP_RS10220	COG1592	Rubrerythrin
AVENP_RS10225	COG1592	Rubrerythrin
AVENP_RS10235	COG0728	peptidoglycan biosynthetic process
AVENP_RS10240	COG1132	(ABC) transporter
AVENP_RS10245	COG0167	dihydroorotate dehydrogenase activity
AVENP_RS10260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVENP_RS10265	COG1028	Short-chain dehydrogenase reductase Sdr
AVENP_RS10270	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AVENP_RS10275	COG0750	zinc metalloprotease
AVENP_RS10280	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AVENP_RS10285	COG1942	4-Oxalocrotonate Tautomerase
AVENP_RS10295	COG0583	DNA-binding transcription factor activity
AVENP_RS10300	COG0134	indole-3-glycerol-phosphate synthase activity
AVENP_RS10310	COG0727	PFAM Uncharacterised protein family (UPF0153)
AVENP_RS10315	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AVENP_RS10325	COG0674	pyruvate-flavodoxin oxidoreductase activity
AVENP_RS10325	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AVENP_RS10330	COG1013	pyruvate-flavodoxin oxidoreductase activity
AVENP_RS10340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AVENP_RS10345	COG2176	DNA-directed DNA polymerase activity
AVENP_RS10350	COG0135	phosphoribosylanthranilate isomerase activity
AVENP_RS10355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AVENP_RS10375	COG0642	Histidine kinase
AVENP_RS10380	COG0745	RESPONSE REGULATOR receiver
AVENP_RS10390	COG0501	Belongs to the peptidase M48B family
AVENP_RS10395	COG1704	LemA family
AVENP_RS10400	COG1666	GTP binding
AVENP_RS10405	COG2233	PERMEase
AVENP_RS10410	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AVENP_RS10420	COG2363	Small membrane protein
AVENP_RS10430	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AVENP_RS10475	COG0166	Belongs to the GPI family
AVENP_RS10490	COG0531	amino acid
AVENP_RS10495	COG4302	ethanolamine ammonia-lyase activity
AVENP_RS10500	COG4303	Ethanolamine ammonia lyase large subunit
AVENP_RS10515	COG0708	Exodeoxyribonuclease III
AVENP_RS10540	COG3706	GGDEF domain
AVENP_RS10600	COG4191	Histidine kinase
AVENP_RS10610	COG2199	diguanylate cyclase activity
AVENP_RS10610	COG3287	FIST C domain
AVENP_RS10610	COG2200	EAL domain
AVENP_RS10615	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AVENP_RS10620	COG1078	dGTPase activity
AVENP_RS10625	COG0259	pyridoxamine-phosphate oxidase activity
AVENP_RS10635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AVENP_RS10645	COG0513	Belongs to the DEAD box helicase family
AVENP_RS10660	COG3287	FIST C domain
AVENP_RS10660	COG2199	diguanylate cyclase activity
AVENP_RS10660	COG2200	EAL domain
AVENP_RS10670	COG1984	allophanate hydrolase subunit 2
AVENP_RS10680	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AVENP_RS10695	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AVENP_RS10700	COG2207	Transcriptional regulator
AVENP_RS10700	COG4753	response regulator
AVENP_RS10735	COG0326	Molecular chaperone. Has ATPase activity
AVENP_RS10740	COG0840	transmembrane signaling receptor activity
AVENP_RS10750	COG0667	Aldo Keto reductase
AVENP_RS10755	COG1414	Transcriptional regulator
AVENP_RS10765	COG2050	protein possibly involved in aromatic compounds catabolism
AVENP_RS10775	COG1012	belongs to the aldehyde dehydrogenase family
AVENP_RS10780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AVENP_RS10785	COG1024	Enoyl-CoA hydratase
AVENP_RS10835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AVENP_RS10860	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AVENP_RS10880	COG2159	amidohydrolase
AVENP_RS10895	COG2828	Protein conserved in bacteria
AVENP_RS10910	COG0753	catalase activity
AVENP_RS10920	COG2995	paraquat-inducible protein a
AVENP_RS10935	COG5001	Diguanylate cyclase
AVENP_RS10935	COG5002	protein histidine kinase activity
AVENP_RS10955	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AVENP_RS10960	COG4335	DNA alkylation repair
AVENP_RS10975	COG2207	Transcriptional regulator
AVENP_RS10975	COG3708	Transcriptional regulator
AVENP_RS10980	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AVENP_RS10985	COG4773	Receptor
AVENP_RS11000	COG0010	Belongs to the arginase family
AVENP_RS11005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVENP_RS11010	COG2207	Transcriptional regulator
AVENP_RS11015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AVENP_RS11045	COG1227	inorganic diphosphatase activity
AVENP_RS11065	COG1027	Aspartate ammonia-lyase
AVENP_RS11070	COG0745	RESPONSE REGULATOR receiver
AVENP_RS11080	COG1115	amino acid carrier protein
AVENP_RS11085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AVENP_RS11090	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AVENP_RS11095	COG1047	Peptidyl-prolyl cis-trans
AVENP_RS11110	COG0823	Involved in the tonB-independent uptake of proteins
AVENP_RS11120	COG0848	biopolymer transport protein
AVENP_RS11125	COG0811	peptide transport
AVENP_RS11130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AVENP_RS11135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AVENP_RS11140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AVENP_RS11145	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AVENP_RS11150	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AVENP_RS11155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AVENP_RS11165	COG1475	DNA binding
AVENP_RS11170	COG1192	Involved in chromosome partitioning
AVENP_RS11175	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AVENP_RS11175	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AVENP_RS11190	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AVENP_RS11195	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AVENP_RS11200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AVENP_RS11205	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AVENP_RS11210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AVENP_RS11220	COG0358	DNA primase activity
AVENP_RS11230	COG0571	ribonuclease III activity
AVENP_RS11235	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AVENP_RS11240	COG1686	Belongs to the peptidase S11 family
AVENP_RS11245	COG0501	Belongs to the peptidase M48B family
AVENP_RS11265	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AVENP_RS11275	COG0706	membrane insertase activity
AVENP_RS11280	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AVENP_RS11285	COG0594	ribonuclease P activity
AVENP_RS11290	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AVENP_RS11295	COG0542	response to heat
AVENP_RS11300	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AVENP_RS11315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVENP_RS11320	COG1696	Membrane protein involved in D-alanine export
AVENP_RS11330	COG1696	Membrane protein involved in D-alanine export
AVENP_RS11340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVENP_RS11345	COG0745	RESPONSE REGULATOR receiver
AVENP_RS11350	COG3437	response regulator, receiver
AVENP_RS11360	COG0179	Fumarylacetoacetate (FAA) hydrolase
AVENP_RS11375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AVENP_RS11390	COG0477	Major facilitator Superfamily
AVENP_RS11405	COG0138	bifunctional purine biosynthesis protein purh
AVENP_RS11410	COG0004	ammonium transporteR
AVENP_RS11415	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AVENP_RS11425	COG1196	nuclear chromosome segregation
AVENP_RS11425	COG0739	heme binding
AVENP_RS11425	COG0741	lytic transglycosylase activity
AVENP_RS11435	COG0456	acetyltransferase
AVENP_RS11440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AVENP_RS11445	COG1917	Cupin 2, conserved barrel domain protein
AVENP_RS11455	COG0527	aspartate kinase activity
AVENP_RS11475	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AVENP_RS11485	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AVENP_RS11490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AVENP_RS11565	COG0302	gtp cyclohydrolase
AVENP_RS11570	COG0598	Magnesium transport protein CorA
AVENP_RS11575	COG1459	type II secretion system
AVENP_RS11580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AVENP_RS11595	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AVENP_RS11600	COG0606	chelatase, subunit chli
AVENP_RS11610	COG0242	peptide deformylase activity
AVENP_RS11615	COG0740	serine-type endopeptidase activity
AVENP_RS11620	COG0544	peptidyl-prolyl cis-trans isomerase activity
AVENP_RS11685	COG1064	alcohol dehydrogenase
AVENP_RS11690	COG2207	Transcriptional regulator
AVENP_RS11695	COG4681	YaeQ
AVENP_RS11705	COG0626	cystathionine gamma-synthase activity
AVENP_RS11715	COG0745	RESPONSE REGULATOR receiver
AVENP_RS11730	COG0840	transmembrane signaling receptor activity
AVENP_RS11735	COG2198	Histidine kinase
AVENP_RS11735	COG0643	Histidine kinase
AVENP_RS11760	COG0745	RESPONSE REGULATOR receiver
AVENP_RS11770	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AVENP_RS11785	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AVENP_RS11790	COG1917	Cupin 2, conserved barrel domain protein
AVENP_RS11790	COG2207	Transcriptional regulator
AVENP_RS11805	COG1301	dicarboxylic acid transport
AVENP_RS11810	COG0840	transmembrane signaling receptor activity
AVENP_RS11825	COG1028	Short-chain dehydrogenase reductase Sdr
AVENP_RS11835	COG0840	transmembrane signaling receptor activity
AVENP_RS11845	COG2199	diguanylate cyclase activity
AVENP_RS11845	COG2200	EAL domain
AVENP_RS11845	COG3287	FIST C domain
AVENP_RS11850	COG0840	transmembrane signaling receptor activity
AVENP_RS11855	COG2200	EAL domain
AVENP_RS11860	COG2223	nitrite transmembrane transporter activity
AVENP_RS11865	COG2815	serine threonine protein kinase
AVENP_RS11865	COG0515	serine threonine protein kinase
AVENP_RS11870	COG2199	diguanylate cyclase activity
AVENP_RS11870	COG3287	FIST C domain
AVENP_RS11870	COG2200	EAL domain
AVENP_RS11875	COG0243	molybdopterin cofactor binding
AVENP_RS11885	COG3287	FIST C domain
AVENP_RS11885	COG2199	diguanylate cyclase activity
AVENP_RS11885	COG2200	EAL domain
AVENP_RS11890	COG0840	transmembrane signaling receptor activity
AVENP_RS11895	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AVENP_RS11900	COG4208	sulfate ABC transporter
AVENP_RS11905	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AVENP_RS11910	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AVENP_RS11915	COG1959	2 iron, 2 sulfur cluster binding
AVENP_RS11920	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AVENP_RS11945	COG1858	cytochrome C peroxidase
AVENP_RS11975	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AVENP_RS11980	COG0840	transmembrane signaling receptor activity
AVENP_RS12020	COG0668	transmembrane transport
AVENP_RS12045	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AVENP_RS12060	COG0348	domain, Protein
AVENP_RS12065	COG4191	Histidine kinase
AVENP_RS12070	COG2207	Transcriptional regulator
AVENP_RS12070	COG4753	response regulator
AVENP_RS12085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AVENP_RS12110	COG0716	FMN binding
AVENP_RS12125	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AVENP_RS12160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVENP_RS12165	COG2201	protein-glutamate methylesterase activity
AVENP_RS12180	COG0784	Response regulator, receiver
AVENP_RS12180	COG3437	response regulator, receiver
AVENP_RS12185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVENP_RS12215	COG0731	radical SAM domain protein
AVENP_RS12220	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AVENP_RS12230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AVENP_RS12245	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AVENP_RS12255	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AVENP_RS12270	COG0438	transferase activity, transferring glycosyl groups
AVENP_RS12295	COG0726	polysaccharide deacetylase
AVENP_RS12310	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AVENP_RS12330	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AVENP_RS12335	COG0483	inositol monophosphate 1-phosphatase activity
AVENP_RS12340	COG0493	'glutamate synthase
AVENP_RS12345	COG0069	glutamate synthase activity
AVENP_RS12345	COG0067	glutamate synthase
AVENP_RS12345	COG0070	glutamate synthase
AVENP_RS12360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AVENP_RS12365	COG0584	glycerophosphoryl diester phosphodiesterase
AVENP_RS12375	COG0745	RESPONSE REGULATOR receiver
AVENP_RS12395	COG0840	transmembrane signaling receptor activity
AVENP_RS12410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVENP_RS12410	COG2205	protein histidine kinase activity
AVENP_RS12465	COG0284	orotidine-5'-phosphate decarboxylase activity
AVENP_RS12470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AVENP_RS12475	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AVENP_RS12480	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AVENP_RS12505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AVENP_RS12530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AVENP_RS12535	COG1450	Type ii and iii secretion system protein
AVENP_RS12595	COG1739	Uncharacterized protein family UPF0029
AVENP_RS12605	COG0196	riboflavin kinase activity
AVENP_RS12610	COG2226	methyltransferase
AVENP_RS12615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AVENP_RS12625	COG0277	FAD linked oxidase domain protein
AVENP_RS12675	COG0542	response to heat
AVENP_RS12680	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AVENP_RS12685	COG0714	Associated with various cellular activities
AVENP_RS12700	COG2304	oxidoreductase activity
AVENP_RS12720	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AVENP_RS12730	COG0318	PFAM AMP-dependent synthetase and ligase
AVENP_RS12735	COG2030	dehydratase
AVENP_RS12755	COG0840	transmembrane signaling receptor activity
AVENP_RS12760	COG1970	mechanosensitive ion channel activity
AVENP_RS12765	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVENP_RS12790	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AVENP_RS12795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AVENP_RS12800	COG1157	protein secretion by the type III secretion system
AVENP_RS12810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AVENP_RS12830	COG1677	Flagellar hook-basal body complex protein FliE
AVENP_RS12840	COG0455	bacterial-type flagellum organization
AVENP_RS12845	COG1419	protein localization to endoplasmic reticulum
AVENP_RS12870	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AVENP_RS12895	COG1749	Flagellar hook protein flgE
AVENP_RS12910	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AVENP_RS12920	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AVENP_RS12925	COG1766	The M ring may be actively involved in energy transduction
AVENP_RS12930	COG1815	bacterial-type flagellum-dependent cell motility
AVENP_RS12935	COG4786	Flagellar basal body rod
AVENP_RS12945	COG0745	RESPONSE REGULATOR receiver
AVENP_RS12965	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AVENP_RS12970	COG1837	Belongs to the UPF0109 family
AVENP_RS12975	COG0228	four-way junction DNA binding
AVENP_RS12980	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AVENP_RS12985	COG0564	pseudouridine synthase activity
AVENP_RS12990	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AVENP_RS12990	COG1519	Transferase
AVENP_RS13000	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AVENP_RS13005	COG0752	glycyl-tRNA synthetase alpha subunit
AVENP_RS13015	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AVENP_RS13030	COG0840	transmembrane signaling receptor activity
AVENP_RS13035	COG0497	DNA recombination
AVENP_RS13040	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AVENP_RS13045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AVENP_RS13050	COG0049	tRNA binding
AVENP_RS13055	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AVENP_RS13060	COG2814	Major facilitator Superfamily
AVENP_RS13065	COG2267	carboxylic ester hydrolase activity
AVENP_RS13080	COG4895	conserved protein (DUF2196)
AVENP_RS13090	COG0840	transmembrane signaling receptor activity
AVENP_RS13110	COG0450	alkyl hydroperoxide reductase
AVENP_RS13115	COG3118	belongs to the thioredoxin family
AVENP_RS13235	COG0582	viral genome integration into host DNA
AVENP_RS13250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AVENP_RS13255	COG0085	RNA polymerase activity
AVENP_RS13260	COG0222	ribosome binding
AVENP_RS13265	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AVENP_RS13270	COG0081	regulation of translation
AVENP_RS13275	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AVENP_RS13280	COG0250	Participates in transcription elongation, termination and antitermination
AVENP_RS13295	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AVENP_RS13300	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AVENP_RS13330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AVENP_RS13335	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AVENP_RS13340	COG0444	Belongs to the ABC transporter superfamily
AVENP_RS13345	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AVENP_RS13350	COG0174	glutamine synthetase
AVENP_RS13360	COG0314	molybdopterin synthase activity
AVENP_RS13370	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AVENP_RS13375	COG1968	undecaprenyl-diphosphatase activity
AVENP_RS13385	COG0772	Belongs to the SEDS family
AVENP_RS13390	COG0768	penicillin binding
AVENP_RS13395	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AVENP_RS13450	COG0512	Glutamine amidotransferase of anthranilate synthase
AVENP_RS13455	COG1840	ABC-type Fe3 transport system, periplasmic component
AVENP_RS13460	COG1178	ABC-type Fe3 transport system permease component
AVENP_RS13465	COG3842	ATPase activity
AVENP_RS13470	COG3706	GGDEF domain
AVENP_RS13505	COG2183	response to ionizing radiation
AVENP_RS13515	COG2199	diguanylate cyclase activity
AVENP_RS13515	COG3287	FIST C domain
AVENP_RS13515	COG2200	EAL domain
AVENP_RS13520	COG0251	oxidation-reduction process
AVENP_RS13535	COG2095	MarC family integral membrane protein
AVENP_RS13540	COG0765	amino acid transport
AVENP_RS13570	COG0840	transmembrane signaling receptor activity
AVENP_RS13580	COG1012	belongs to the aldehyde dehydrogenase family
AVENP_RS13585	COG0410	ABC transporter
AVENP_RS13630	COG0586	Pfam SNARE associated Golgi protein
AVENP_RS13640	COG0335	large ribosomal subunit rRNA binding
AVENP_RS13645	COG0336	Belongs to the RNA methyltransferase TrmD family
AVENP_RS13655	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AVENP_RS13660	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AVENP_RS13665	COG0356	it plays a direct role in the translocation of protons across the membrane
AVENP_RS13675	COG1074	ATP-dependent DNA helicase activity
AVENP_RS13680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AVENP_RS13685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AVENP_RS13690	COG0723	plastoquinol--plastocyanin reductase activity
AVENP_RS13695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AVENP_RS13710	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AVENP_RS13720	COG0303	'Molybdopterin
AVENP_RS13725	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AVENP_RS13735	COG0602	queuosine metabolic process
AVENP_RS13745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVENP_RS13755	COG0825	malonyl-CoA metabolic process
AVENP_RS13760	COG0537	adenosine 5'-monophosphoramidase activity
AVENP_RS13765	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AVENP_RS13770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVENP_RS13770	COG0072	phenylalanine-tRNA ligase activity
AVENP_RS13775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AVENP_RS13780	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AVENP_RS13785	COG0539	negative regulation of cytoplasmic translation
AVENP_RS13785	COG1185	polyribonucleotide nucleotidyltransferase activity
AVENP_RS13790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVENP_RS13795	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AVENP_RS13800	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVENP_RS13800	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVENP_RS13805	COG0779	Required for maturation of 30S ribosomal subunits
AVENP_RS13810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AVENP_RS13815	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AVENP_RS13825	COG0083	homoserine kinase activity
AVENP_RS13835	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AVENP_RS13850	COG0157	Belongs to the NadC ModD family
AVENP_RS13860	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AVENP_RS13870	COG4773	Receptor
AVENP_RS13880	COG4773	Receptor
AVENP_RS13885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AVENP_RS13900	COG1289	transmembrane transporter activity
AVENP_RS13950	COG3278	Belongs to the heme-copper respiratory oxidase family
AVENP_RS13955	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AVENP_RS13960	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AVENP_RS13965	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AVENP_RS13970	COG0210	DNA helicase
AVENP_RS13980	COG3153	acetyltransferase
AVENP_RS13980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AVENP_RS13985	COG1242	4 iron, 4 sulfur cluster binding
AVENP_RS13990	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AVENP_RS13995	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AVENP_RS14000	COG0492	ferredoxin-NADP+ reductase activity
AVENP_RS14005	COG3118	belongs to the thioredoxin family
AVENP_RS14010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AVENP_RS14030	COG0791	NLP P60 protein
AVENP_RS14035	COG0791	NLP P60 protein
AVENP_RS14060	COG0424	maF-like protein
AVENP_RS14070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AVENP_RS14075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVENP_RS14080	COG0077	Prephenate dehydratase
AVENP_RS14080	COG1605	Chorismate mutase
AVENP_RS14085	COG0019	diaminopimelate decarboxylase activity
AVENP_RS14090	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AVENP_RS14095	COG0149	triose-phosphate isomerase activity
AVENP_RS14100	COG0126	phosphoglycerate kinase activity
AVENP_RS14110	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AVENP_RS14120	COG0018	arginyl-trna synthetase
AVENP_RS14125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AVENP_RS14130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AVENP_RS14135	COG0204	Acyl-transferase
AVENP_RS14145	COG0047	phosphoribosylformylglycinamidine synthase activity
AVENP_RS14150	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AVENP_RS14155	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AVENP_RS14160	COG0793	Belongs to the peptidase S41A family
AVENP_RS14175	COG0585	pseudouridine synthase activity
AVENP_RS14180	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AVENP_RS14190	COG1136	(ABC) transporter
AVENP_RS14190	COG0577	efflux transmembrane transporter activity
AVENP_RS14300	COG0129	dihydroxy-acid dehydratase activity
AVENP_RS14310	COG0745	RESPONSE REGULATOR receiver
AVENP_RS14315	COG0642	Histidine kinase
AVENP_RS14330	COG0702	epimerase
AVENP_RS14345	COG1492	cobalamin metabolic process
AVENP_RS14350	COG2205	protein histidine kinase activity
AVENP_RS14370	COG4771	TonB-dependent receptor
AVENP_RS14380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVENP_RS14395	COG2095	MarC family integral membrane protein
AVENP_RS14400	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AVENP_RS14405	COG0745	RESPONSE REGULATOR receiver
AVENP_RS14410	COG5002	protein histidine kinase activity
AVENP_RS14420	COG0745	RESPONSE REGULATOR receiver
AVENP_RS14425	COG3852	Histidine kinase
AVENP_RS14430	COG0252	asparaginase activity
AVENP_RS14435	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AVENP_RS14440	COG1027	Aspartate ammonia-lyase
AVENP_RS14450	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AVENP_RS14455	COG1053	succinate dehydrogenase
AVENP_RS14465	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
AVENP_RS14470	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AVENP_RS14475	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AVENP_RS14480	COG2199	diguanylate cyclase activity
AVENP_RS14480	COG3287	FIST C domain
AVENP_RS14480	COG2200	EAL domain
AVENP_RS14490	COG4232	protein-disulfide reductase activity
AVENP_RS14495	COG3118	belongs to the thioredoxin family
AVENP_RS14510	COG0189	ligase activity
AVENP_RS14525	COG3287	FIST C domain
AVENP_RS14525	COG2199	diguanylate cyclase activity
AVENP_RS14525	COG2200	EAL domain
AVENP_RS14550	COG0443	Heat shock 70 kDa protein
AVENP_RS14555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AVENP_RS14560	COG1420	regulation of RNA biosynthetic process
AVENP_RS14575	COG2197	response regulator
AVENP_RS14585	COG0101	tRNA pseudouridine synthase activity
AVENP_RS14595	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AVENP_RS14600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AVENP_RS14605	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AVENP_RS14610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AVENP_RS14620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AVENP_RS14625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AVENP_RS14670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AVENP_RS14690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AVENP_RS14695	COG2226	methyltransferase
AVENP_RS14715	COG1216	Glycosyl transferase, family 2
AVENP_RS14735	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AVENP_RS14750	COG1028	Short-chain dehydrogenase reductase Sdr
AVENP_RS14760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVENP_RS14765	COG3980	spore coat polysaccharide biosynthesis protein
AVENP_RS14770	COG2089	acid synthase
AVENP_RS14775	COG1083	cytidylyl-transferase
AVENP_RS14780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AVENP_RS14785	COG1086	Polysaccharide biosynthesis protein
AVENP_RS14795	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AVENP_RS14800	COG0148	phosphopyruvate hydratase activity
AVENP_RS14815	COG0475	glutathione-regulated potassium exporter activity
AVENP_RS14815	COG0569	domain protein
AVENP_RS14820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AVENP_RS14835	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AVENP_RS14840	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AVENP_RS14850	COG1007	ATP synthesis coupled electron transport
AVENP_RS14860	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AVENP_RS14865	COG0713	ATP synthesis coupled electron transport
AVENP_RS14870	COG0839	Belongs to the complex I subunit 6 family
AVENP_RS14875	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVENP_RS14880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AVENP_RS14900	COG0649	NAD binding
AVENP_RS14905	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVENP_RS14910	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVENP_RS14915	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVENP_RS14920	COG1222	aaa ATPase
AVENP_RS14950	COG0659	secondary active sulfate transmembrane transporter activity
AVENP_RS14965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVENP_RS14970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVENP_RS14980	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AVENP_RS14985	COG1252	NADH dehydrogenase
AVENP_RS14990	COG2200	EAL domain
AVENP_RS14990	COG2199	diguanylate cyclase activity
AVENP_RS14990	COG3287	FIST C domain
AVENP_RS14995	COG0733	neurotransmitter:sodium symporter activity
AVENP_RS15005	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AVENP_RS15015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AVENP_RS15020	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVENP_RS15025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AVENP_RS15045	COG0445	tRNA wobble uridine modification
AVENP_RS15055	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AVENP_RS15055	COG3608	succinylglutamate desuccinylase aspartoacylase
AVENP_RS15060	COG2010	Cytochrome c
AVENP_RS15060	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVENP_RS15080	COG0348	domain, Protein
AVENP_RS15085	COG0504	CTP synthase activity
AVENP_RS15090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AVENP_RS15090	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AVENP_RS15120	COG0587	DNA-directed DNA polymerase activity
AVENP_RS15125	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AVENP_RS15140	COG0315	cyclic pyranopterin monophosphate synthase activity
AVENP_RS15145	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AVENP_RS15160	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AVENP_RS15165	COG0159	tryptophan synthase activity
AVENP_RS15170	COG0038	chloride channel
AVENP_RS15175	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AVENP_RS15180	COG2255	four-way junction helicase activity
AVENP_RS15185	COG0628	permease
AVENP_RS15195	COG4628	conserved protein (DUF2132)
AVENP_RS15255	COG0670	Belongs to the BI1 family
AVENP_RS15260	COG0352	thiamine-phosphate diphosphorylase activity
AVENP_RS15270	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AVENP_RS15280	COG0233	cytoplasmic translational termination
AVENP_RS15285	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AVENP_RS15295	COG2814	Major facilitator Superfamily
AVENP_RS15300	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AVENP_RS15300	COG3264	Mechanosensitive ion channel
AVENP_RS15315	COG3022	response to hydroperoxide
AVENP_RS15320	COG3012	SEC-C Motif Domain Protein
AVENP_RS15400	COG3210	domain, Protein
AVENP_RS15400	COG3210	domain, Protein
AVENP_RS15405	COG2831	hemolysin activation secretion protein
AVENP_RS15410	COG0848	biopolymer transport protein
AVENP_RS15415	COG0811	peptide transport
AVENP_RS15435	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AVENP_RS15440	COG1012	belongs to the aldehyde dehydrogenase family
AVENP_RS15445	COG0589	response to stress
AVENP_RS15460	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AVENP_RS15465	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AVENP_RS15480	COG0745	RESPONSE REGULATOR receiver
AVENP_RS15485	COG1012	belongs to the aldehyde dehydrogenase family
AVENP_RS15490	COG0028	Belongs to the TPP enzyme family
AVENP_RS15495	COG1704	LemA family
AVENP_RS15510	COG0546	phosphoglycolate phosphatase activity
AVENP_RS15525	COG2814	Major facilitator Superfamily
AVENP_RS15540	COG0840	transmembrane signaling receptor activity
AVENP_RS15545	COG3437	response regulator, receiver
AVENP_RS15545	COG0784	Response regulator, receiver
AVENP_RS15585	COG2081	HI0933 family
AVENP_RS15600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVENP_RS15635	COG1959	2 iron, 2 sulfur cluster binding
AVENP_RS15650	COG0175	sulfate reduction
AVENP_RS15655	COG0175	sulfate reduction
AVENP_RS15660	COG2895	sulfate adenylyltransferase (ATP) activity
AVENP_RS15665	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AVENP_RS15670	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVENP_RS15675	COG1408	metallophosphoesterase
AVENP_RS15690	COG2308	Evidence 4 Homologs of previously reported genes of
AVENP_RS15700	COG0840	transmembrane signaling receptor activity
AVENP_RS15720	COG2308	Evidence 4 Homologs of previously reported genes of
AVENP_RS15740	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AVENP_RS15765	COG0745	RESPONSE REGULATOR receiver
AVENP_RS15770	COG0642	Histidine kinase
AVENP_RS15775	COG3721	Heme iron utilization protein
AVENP_RS15780	COG1132	(ABC) transporter
AVENP_RS15790	COG0748	coenzyme F420 binding
AVENP_RS15795	COG4558	Periplasmic binding protein
AVENP_RS15800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVENP_RS15805	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AVENP_RS15810	COG4771	TonB-dependent receptor
AVENP_RS15820	COG2226	methyltransferase
AVENP_RS15825	COG0784	Response regulator, receiver
AVENP_RS15825	COG3437	response regulator, receiver
AVENP_RS15830	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AVENP_RS15835	COG2066	Belongs to the glutaminase family
AVENP_RS15840	COG2860	membrane
AVENP_RS15850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AVENP_RS15855	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group