locus-tag	class	description
EB_RS00145	COG2204	response regulator
EB_RS00155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EB_RS00160	COG0657	acetylesterase activity
EB_RS00180	COG2354	Protein conserved in bacteria
EB_RS00210	COG0242	peptide deformylase activity
EB_RS00215	COG1490	D-aminoacyl-tRNA deacylase activity
EB_RS00240	COG1484	DNA-dependent DNA replication
EB_RS00335	COG0009	L-threonylcarbamoyladenylate synthase
EB_RS00340	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EB_RS00345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EB_RS00350	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EB_RS00365	COG4566	intracellular signal transduction
EB_RS00380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EB_RS00385	COG0508	dehydrogenase complex catalyzes the overall conversion of
EB_RS00390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EB_RS00410	COG2135	peptidase activity
EB_RS00420	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EB_RS00425	COG2154	pterin-4-alpha-carbinolamine dehydratase
EB_RS00430	COG0028	Belongs to the TPP enzyme family
EB_RS00435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EB_RS00450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EB_RS00455	COG2010	Cytochrome c
EB_RS00455	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EB_RS00475	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EB_RS00480	COG2176	DNA-directed DNA polymerase activity
EB_RS00480	COG5002	protein histidine kinase activity
EB_RS00485	COG0745	RESPONSE REGULATOR receiver
EB_RS00490	COG5002	protein histidine kinase activity
EB_RS00500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EB_RS00525	COG2010	Cytochrome c
EB_RS00530	COG3256	nitric oxide reductase
EB_RS00565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EB_RS00585	COG1484	DNA-dependent DNA replication
EB_RS00605	COG4584	PFAM Integrase catalytic
EB_RS00610	COG1484	DNA-dependent DNA replication
EB_RS00635	COG0582	viral genome integration into host DNA
EB_RS00640	COG0589	response to stress
EB_RS00660	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EB_RS00665	COG0710	3-dehydroquinate dehydratase activity
EB_RS00725	COG4584	PFAM Integrase catalytic
EB_RS00730	COG1484	DNA-dependent DNA replication
EB_RS00740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EB_RS00745	COG1111	helicase
EB_RS00745	COG1205	dead DEAH box helicase
EB_RS00760	COG0210	DNA helicase
EB_RS00785	COG1484	DNA-dependent DNA replication
EB_RS00790	COG3609	addiction module antidote protein, CC2985 family
EB_RS00820	COG0604	alcohol dehydrogenase
EB_RS00830	COG0183	Belongs to the thiolase family
EB_RS00860	COG0439	Biotin carboxylase
EB_RS00865	COG0511	ligase activity, forming carbon-carbon bonds
EB_RS00875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EB_RS01005	COG1192	Involved in chromosome partitioning
EB_RS01020	COG4372	Transposase
EB_RS01170	COG0277	FAD linked oxidase domain protein
EB_RS01175	COG4372	Transposase
EB_RS01215	COG2124	cytochrome p450
EB_RS01230	COG0129	dihydroxy-acid dehydratase activity
EB_RS01245	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EB_RS01250	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EB_RS01265	COG4974	Belongs to the 'phage' integrase family
EB_RS01270	COG0582	viral genome integration into host DNA
EB_RS01275	COG4974	Belongs to the 'phage' integrase family
EB_RS01280	COG4974	Belongs to the 'phage' integrase family
EB_RS01285	COG4974	Belongs to the 'phage' integrase family
EB_RS01290	COG4974	Belongs to the 'phage' integrase family
EB_RS01295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EB_RS01305	COG1819	glycosyl
EB_RS01360	COG2003	Belongs to the UPF0758 family
EB_RS01365	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EB_RS01385	COG3384	dioxygenase
EB_RS01415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EB_RS01420	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EB_RS01420	COG0506	proline dehydrogenase activity
EB_RS01420	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EB_RS01430	COG1320	monovalent cation:proton antiporter activity
EB_RS01435	COG2212	antiporter activity
EB_RS01440	COG1863	multisubunit Na H antiporter MnhE subunit
EB_RS01445	COG0651	ATP synthesis coupled electron transport
EB_RS01450	COG1006	Multisubunit Na H antiporter MnhC subunit
EB_RS01455	COG2111	Na H antiporter
EB_RS01455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EB_RS01515	COG0366	Alpha amylase catalytic
EB_RS01520	COG0837	glucose binding
EB_RS01525	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EB_RS01530	COG1597	lipid kinase activity
EB_RS01540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EB_RS01545	COG1448	Aminotransferase
EB_RS01555	COG1368	sulfuric ester hydrolase activity
EB_RS01560	COG0463	Glycosyl transferase, family 2
EB_RS01580	COG3033	Beta-eliminating lyase
EB_RS01590	COG0671	phosphoesterase, PA-phosphatase related
EB_RS01595	COG2217	Heavy metal translocating P-type atpase
EB_RS01630	COG3258	Cytochrome c
EB_RS01635	COG2863	cytochrome
EB_RS01665	COG1484	DNA-dependent DNA replication
EB_RS01685	COG0527	aspartate kinase activity
EB_RS01700	COG0720	synthase
EB_RS01710	COG3264	Mechanosensitive ion channel
EB_RS01710	COG1511	domain protein
EB_RS01715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EB_RS01720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EB_RS01720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EB_RS01730	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EB_RS01735	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EB_RS01760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EB_RS01765	COG3177	Filamentation induced by cAMP protein fic
EB_RS01805	COG4372	Transposase
EB_RS01825	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EB_RS01835	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EB_RS01840	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EB_RS01855	COG1309	transcriptional regulator
EB_RS01860	COG1024	Enoyl-CoA hydratase
EB_RS01865	COG1024	Enoyl-CoA hydratase
EB_RS01870	COG1028	Short-chain dehydrogenase reductase Sdr
EB_RS01885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EB_RS01900	COG1960	acyl-CoA dehydrogenase activity
EB_RS01930	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
EB_RS02000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EB_RS02010	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EB_RS02015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EB_RS02020	COG0123	including yeast histone deacetylase and acetoin utilization protein
EB_RS02025	COG2951	lytic endotransglycosylase activity
EB_RS02030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EB_RS02040	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EB_RS02045	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EB_RS02060	COG1484	DNA-dependent DNA replication
EB_RS02065	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EB_RS02070	COG0784	Response regulator, receiver
EB_RS02070	COG2205	protein histidine kinase activity
EB_RS02070	COG2198	Histidine kinase
EB_RS02140	COG0583	DNA-binding transcription factor activity
EB_RS02150	COG0730	response to heat
EB_RS02155	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EB_RS02190	COG0538	isocitrate dehydrogenase activity
EB_RS02205	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
EB_RS02215	COG0756	dUTP diphosphatase activity
EB_RS02225	COG2003	Belongs to the UPF0758 family
EB_RS02230	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EB_RS02235	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EB_RS02240	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EB_RS02245	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EB_RS02270	COG0432	Pfam Uncharacterised protein family UPF0047
EB_RS02285	COG4372	Transposase
EB_RS02300	COG3706	GGDEF domain
EB_RS02315	COG0776	regulation of translation
EB_RS02320	COG0072	phenylalanine-tRNA ligase activity
EB_RS02320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EB_RS02325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EB_RS02330	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EB_RS02335	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EB_RS02340	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EB_RS02345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EB_RS02355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EB_RS02360	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EB_RS02370	COG0535	radical SAM domain protein
EB_RS02390	COG3391	amine dehydrogenase activity
EB_RS02400	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EB_RS02400	COG1648	precorrin-2 dehydrogenase activity
EB_RS02450	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EB_RS02460	COG0776	regulation of translation
EB_RS02470	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EB_RS02475	COG0287	Prephenate dehydrogenase
EB_RS02485	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EB_RS02495	COG0402	S-adenosylhomocysteine deaminase activity
EB_RS02505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EB_RS02535	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EB_RS02540	COG0739	heme binding
EB_RS02545	COG0316	Belongs to the HesB IscA family
EB_RS02550	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EB_RS02555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EB_RS02560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EB_RS02565	COG1765	OsmC-like protein
EB_RS02570	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
EB_RS02590	COG0494	nUDIX hydrolase
EB_RS02595	COG0442	prolyl-tRNA aminoacylation
EB_RS02600	COG0741	lytic transglycosylase activity
EB_RS02610	COG2205	protein histidine kinase activity
EB_RS02620	COG2204	response regulator
EB_RS02630	COG0312	modulator of DNA gyrase
EB_RS02645	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EB_RS02665	COG0482	sulfurtransferase activity
EB_RS02700	COG4191	Histidine kinase
EB_RS02705	COG2204	response regulator
EB_RS02735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EB_RS02740	COG2096	Adenosyltransferase
EB_RS02745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EB_RS02750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EB_RS02755	COG0521	Mo-molybdopterin cofactor biosynthetic process
EB_RS02760	COG3028	Belongs to the UPF0307 family
EB_RS02765	COG0312	modulator of DNA gyrase
EB_RS02770	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EB_RS02775	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EB_RS02785	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EB_RS02795	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EB_RS02800	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EB_RS02805	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EB_RS02805	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EB_RS02810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EB_RS02820	COG0793	Belongs to the peptidase S41A family
EB_RS02830	COG0588	phosphoglycerate mutase activity
EB_RS02840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EB_RS02850	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EB_RS02860	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EB_RS02865	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EB_RS02870	COG1040	competence protein
EB_RS02875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EB_RS02880	COG2226	methyltransferase
EB_RS02895	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EB_RS02905	COG0303	'Molybdopterin
EB_RS02910	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EB_RS02920	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EB_RS02925	COG3447	MASE1 domain protein
EB_RS02925	COG5001	Diguanylate cyclase
EB_RS02925	COG5002	protein histidine kinase activity
EB_RS02930	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EB_RS02930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EB_RS02935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EB_RS02945	COG0483	inositol monophosphate 1-phosphatase activity
EB_RS02950	COG3954	Phosphoribulokinase
EB_RS02955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EB_RS02960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EB_RS02965	COG0126	phosphoglycerate kinase activity
EB_RS02970	COG0469	pyruvate kinase activity
EB_RS02985	COG1215	transferase activity, transferring glycosyl groups
EB_RS03005	COG2885	chlorophyll binding
EB_RS03015	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EB_RS03040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EB_RS03050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EB_RS03055	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EB_RS03060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EB_RS03065	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EB_RS03075	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EB_RS03080	COG0006	proline dipeptidase activity
EB_RS03085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EB_RS03090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EB_RS03095	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EB_RS03100	COG0138	bifunctional purine biosynthesis protein purh
EB_RS03105	COG0151	Belongs to the GarS family
EB_RS03110	COG0408	coproporphyrinogen oxidase activity
EB_RS03120	COG2959	enzyme of heme biosynthesis
EB_RS03130	COG0181	hydroxymethylbilane synthase activity
EB_RS03135	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EB_RS03145	COG0165	Argininosuccinate lyase
EB_RS03170	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EB_RS03180	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EB_RS03185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EB_RS03195	COG0642	Histidine kinase
EB_RS03205	COG0459	protein refolding
EB_RS03210	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EB_RS03225	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EB_RS03230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EB_RS03235	COG2969	positive regulation of protein catabolic process
EB_RS03240	COG0625	glutathione transferase activity
EB_RS03245	COG2857	Cytochrome c1
EB_RS03250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EB_RS03255	COG0723	plastoquinol--plastocyanin reductase activity
EB_RS03260	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EB_RS03265	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EB_RS03270	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EB_RS03275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EB_RS03285	COG0243	molybdopterin cofactor binding
EB_RS03295	COG2223	nitrite transmembrane transporter activity
EB_RS03305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EB_RS03320	COG2165	general secretion pathway protein
EB_RS03325	COG1459	type II secretion system
EB_RS03375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EB_RS03380	COG0557	exoribonuclease II activity
EB_RS03395	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EB_RS03400	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EB_RS03410	COG0330	HflC and HflK could
EB_RS03415	COG0330	HflC and HflK could
EB_RS03420	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EB_RS03425	COG1923	regulation of RNA biosynthetic process
EB_RS03430	COG1160	GTP binding
EB_RS03435	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EB_RS03445	COG0124	histidyl-tRNA synthetase
EB_RS03450	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EB_RS03465	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EB_RS03470	COG0105	UTP biosynthetic process
EB_RS03475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EB_RS03480	COG0045	succinate-CoA ligase (ADP-forming) activity
EB_RS03505	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EB_RS03515	COG0805	protein transport
EB_RS03520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EB_RS03525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EB_RS03535	COG0140	phosphoribosyl-ATP diphosphatase activity
EB_RS03540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EB_RS03545	COG0107	imidazoleglycerol-phosphate synthase activity
EB_RS03550	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EB_RS03555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EB_RS03560	COG0131	Imidazoleglycerol-phosphate dehydratase
EB_RS03565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EB_RS03570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EB_RS03575	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EB_RS03580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EB_RS03585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EB_RS03595	COG0842	Transport permease protein
EB_RS03600	COG1131	(ABC) transporter
EB_RS03615	COG2853	Lipoprotein
EB_RS03620	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EB_RS03625	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EB_RS03630	COG1127	ABC transporter
EB_RS03645	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EB_RS03655	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EB_RS03660	COG1024	Enoyl-CoA hydratase
EB_RS03675	COG0204	Acyl-transferase
EB_RS03680	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EB_RS03685	COG0751	glycine-tRNA ligase activity
EB_RS03690	COG0752	glycyl-tRNA synthetase alpha subunit
EB_RS03695	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EB_RS03700	COG4535	Mg2 and Co2 transporter CorC
EB_RS03705	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EB_RS03710	COG1702	phosphate starvation-inducible protein PhoH
EB_RS03715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EB_RS03745	COG1484	DNA-dependent DNA replication
EB_RS03770	COG0582	viral genome integration into host DNA
EB_RS03815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EB_RS03830	COG0477	Major facilitator Superfamily
EB_RS03835	COG2177	Part of the ABC transporter FtsEX involved in
EB_RS03840	COG2884	Cell division ATP-binding protein ftsE
EB_RS03850	COG0612	Peptidase, M16
EB_RS03860	COG0742	ribosomal rna small subunit methyltransferase
EB_RS03865	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EB_RS03870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EB_RS03875	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EB_RS03880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EB_RS03890	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EB_RS03895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EB_RS03905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EB_RS03910	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EB_RS03915	COG0193	aminoacyl-tRNA hydrolase activity
EB_RS03925	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EB_RS03930	COG0343	queuine tRNA-ribosyltransferase activity
EB_RS03935	COG1862	Preprotein translocase
EB_RS03945	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EB_RS03960	COG2967	ApaG domain
EB_RS03990	COG0582	viral genome integration into host DNA
EB_RS03995	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EB_RS04000	COG0653	protein targeting
EB_RS04015	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EB_RS04030	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EB_RS04035	COG1181	Belongs to the D-alanine--D-alanine ligase family
EB_RS04040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EB_RS04045	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EB_RS04050	COG0772	Belongs to the SEDS family
EB_RS04055	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EB_RS04060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EB_RS04065	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EB_RS04070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EB_RS04085	COG0275	rRNA processing
EB_RS04090	COG2001	Belongs to the MraZ family
EB_RS04095	COG0418	dihydroorotase activity
EB_RS04105	COG0792	nuclease activity
EB_RS04110	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EB_RS04115	COG2823	Periplasmic or secreted lipoprotein
EB_RS04120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EB_RS04130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EB_RS04135	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EB_RS04140	COG0511	ligase activity, forming carbon-carbon bonds
EB_RS04145	COG0439	Biotin carboxylase
EB_RS04150	COG2264	protein methyltransferase activity
EB_RS04175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EB_RS04180	COG0537	adenosine 5'-monophosphoramidase activity
EB_RS04245	COG0438	transferase activity, transferring glycosyl groups
EB_RS04255	COG1088	dTDP-glucose 4,6-dehydratase activity
EB_RS04260	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EB_RS04275	COG0438	transferase activity, transferring glycosyl groups
EB_RS04280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EB_RS04285	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EB_RS04300	COG0438	transferase activity, transferring glycosyl groups
EB_RS04310	COG4115	mRNA cleavage
EB_RS04315	COG4372	Transposase
EB_RS04340	COG1724	mRNA binding
EB_RS04345	COG1598	PFAM Uncharacterised protein family UPF0150
EB_RS04450	COG1450	Type ii and iii secretion system protein
EB_RS04480	COG2165	general secretion pathway protein
EB_RS04490	COG2165	general secretion pathway protein
EB_RS04495	COG1459	type II secretion system
EB_RS04500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EB_RS04520	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EB_RS04535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EB_RS04555	COG1538	Outer membrane efflux protein
EB_RS04560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EB_RS04565	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EB_RS04625	COG2274	protein secretion by the type I secretion system
EB_RS04630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EB_RS04635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EB_RS04645	COG1538	Outer membrane efflux protein
EB_RS04650	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EB_RS04660	COG0515	serine threonine protein kinase
EB_RS04660	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EB_RS04695	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
EB_RS04700	COG2119	membrane
EB_RS04705	COG0351	phosphomethylpyrimidine kinase
EB_RS04710	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EB_RS04755	COG1968	undecaprenyl-diphosphatase activity
EB_RS04760	COG3150	esterase
EB_RS04765	COG2226	methyltransferase
EB_RS04770	COG0557	exoribonuclease II activity
EB_RS04780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EB_RS04785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EB_RS04790	COG2239	Acts as a magnesium transporter
EB_RS04795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EB_RS04800	COG0352	thiamine-phosphate diphosphorylase activity
EB_RS04805	COG0351	phosphomethylpyrimidine kinase
EB_RS04830	COG0840	transmembrane signaling receptor activity
EB_RS04835	COG0643	Histidine kinase
EB_RS04835	COG2198	Histidine kinase
EB_RS04840	COG1678	Uncharacterized ACR, COG1678
EB_RS04845	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EB_RS04850	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EB_RS04855	COG0540	Belongs to the ATCase OTCase family
EB_RS04860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EB_RS04865	COG1872	DUF167
EB_RS04870	COG0762	integral membrane protein
EB_RS04900	COG1981	membrane
EB_RS04930	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EB_RS04930	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EB_RS04945	COG2200	EAL domain
EB_RS04965	COG4566	intracellular signal transduction
EB_RS04970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EB_RS04975	COG2274	protein secretion by the type I secretion system
EB_RS04980	COG0735	belongs to the Fur family
EB_RS04985	COG1121	(ABC) transporter
EB_RS04995	COG0803	Belongs to the bacterial solute-binding protein 9 family
EB_RS05000	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EB_RS05005	COG0730	response to heat
EB_RS05020	COG0129	dihydroxy-acid dehydratase activity
EB_RS05025	COG3132	Protein of unknown function, DUF480
EB_RS05030	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EB_RS05090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EB_RS05095	COG0577	efflux transmembrane transporter activity
EB_RS05095	COG1136	(ABC) transporter
EB_RS05150	COG0672	)-iron permease
EB_RS05160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EB_RS05165	COG1278	Cold shock
EB_RS05170	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EB_RS05175	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EB_RS05190	COG0433	COG0433 Predicted ATPase
EB_RS05195	COG0183	Belongs to the thiolase family
EB_RS05200	COG1250	3-hydroxyacyl-CoA dehydrogenase
EB_RS05205	COG1024	Enoyl-CoA hydratase
EB_RS05270	COG2814	Major facilitator Superfamily
EB_RS05300	COG1024	Enoyl-CoA hydratase
EB_RS05325	COG1028	Short-chain dehydrogenase reductase Sdr
EB_RS05330	COG1028	Short-chain dehydrogenase reductase Sdr
EB_RS05335	COG1028	Short-chain dehydrogenase reductase Sdr
EB_RS05335	COG0604	alcohol dehydrogenase
EB_RS05335	COG3321	synthase
EB_RS05350	COG1484	DNA-dependent DNA replication
EB_RS05390	COG5433	transposase activity
EB_RS05405	COG4974	Belongs to the 'phage' integrase family
EB_RS05410	COG0517	IMP dehydrogenase activity
EB_RS05415	COG4974	Belongs to the 'phage' integrase family
EB_RS05435	COG1960	acyl-CoA dehydrogenase activity
EB_RS05440	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EB_RS05450	COG1846	Transcriptional regulator
EB_RS05455	COG1960	acyl-CoA dehydrogenase activity
EB_RS05460	COG0318	PFAM AMP-dependent synthetase and ligase
EB_RS05465	COG1024	Enoyl-CoA hydratase
EB_RS05480	COG1309	transcriptional regulator
EB_RS05485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EB_RS05490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EB_RS05510	COG0783	Belongs to the Dps family
EB_RS05515	COG0443	Heat shock 70 kDa protein
EB_RS05520	COG0443	Heat shock 70 kDa protein
EB_RS05535	COG1960	acyl-CoA dehydrogenase activity
EB_RS05540	COG0492	ferredoxin-NADP+ reductase activity
EB_RS05620	COG1484	DNA-dependent DNA replication
EB_RS05635	COG4453	Protein conserved in bacteria
EB_RS05640	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EB_RS05655	COG2816	NAD+ diphosphatase activity
EB_RS05660	COG2205	protein histidine kinase activity
EB_RS05670	COG2909	trisaccharide binding
EB_RS05695	COG1250	3-hydroxyacyl-CoA dehydrogenase
EB_RS05695	COG1024	Enoyl-CoA hydratase
EB_RS05700	COG1309	transcriptional regulator
EB_RS05705	COG1802	Transcriptional regulator
EB_RS05730	COG1960	acyl-CoA dehydrogenase activity
EB_RS05735	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EB_RS05735	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EB_RS05740	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EB_RS05740	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EB_RS05760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EB_RS05810	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EB_RS05815	COG3608	succinylglutamate desuccinylase aspartoacylase
EB_RS05815	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EB_RS05835	COG1902	pentaerythritol trinitrate reductase activity
EB_RS05835	COG0446	pyridine nucleotide-disulphide oxidoreductase
EB_RS05845	COG0753	catalase activity
EB_RS05860	COG2193	ferroxidase activity
EB_RS05865	COG3842	ATPase activity
EB_RS05875	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EB_RS05900	COG1484	DNA-dependent DNA replication
EB_RS05940	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EB_RS05965	COG2201	protein-glutamate methylesterase activity
EB_RS05970	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EB_RS06015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EB_RS06020	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EB_RS06045	COG2770	Histidine kinase
EB_RS06045	COG3437	response regulator, receiver
EB_RS06055	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EB_RS06070	COG1024	Enoyl-CoA hydratase
EB_RS06110	COG2853	Lipoprotein
EB_RS06130	COG1138	Cytochrome C-type biogenesis protein
EB_RS06140	COG1132	(ABC) transporter
EB_RS06155	COG0641	radical SAM
EB_RS06180	COG0826	peptidase U32
EB_RS06185	COG1012	belongs to the aldehyde dehydrogenase family
EB_RS06190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EB_RS06195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EB_RS06205	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EB_RS06215	COG0067	glutamate synthase
EB_RS06215	COG0069	glutamate synthase activity
EB_RS06215	COG0070	glutamate synthase
EB_RS06220	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EB_RS06225	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EB_RS06230	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EB_RS06265	COG1965	Belongs to the frataxin family
EB_RS06295	COG1088	dTDP-glucose 4,6-dehydratase activity
EB_RS06310	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EB_RS06325	COG0284	orotidine-5'-phosphate decarboxylase activity
EB_RS06335	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EB_RS06340	COG3161	chorismate lyase activity
EB_RS06345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EB_RS06360	COG0655	NAD(P)H dehydrogenase (quinone) activity
EB_RS06365	COG1741	Belongs to the pirin family
EB_RS06390	COG3668	Plasmid stabilization system
EB_RS06395	COG1024	Enoyl-CoA hydratase
EB_RS06400	COG0183	Belongs to the thiolase family
EB_RS06405	COG1024	Enoyl-CoA hydratase
EB_RS06405	COG1250	3-hydroxyacyl-CoA dehydrogenase
EB_RS06410	COG2067	long-chain fatty acid transport protein
EB_RS06415	COG1607	acyl-coa hydrolase
EB_RS06420	COG1024	Enoyl-CoA hydratase
EB_RS06420	COG1250	3-hydroxyacyl-CoA dehydrogenase
EB_RS06430	COG1960	acyl-CoA dehydrogenase activity
EB_RS06440	COG1561	YicC-like family, N-terminal region
EB_RS06445	COG0515	serine threonine protein kinase
EB_RS06455	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EB_RS06460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EB_RS06465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EB_RS06475	COG0616	signal peptide processing
EB_RS06480	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EB_RS06485	COG2022	thiamine diphosphate biosynthetic process
EB_RS06500	COG0582	viral genome integration into host DNA
EB_RS06510	COG1396	sequence-specific DNA binding
EB_RS06515	COG0583	DNA-binding transcription factor activity
EB_RS06520	COG0644	oxidoreductase
EB_RS06520	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
EB_RS06525	COG0523	cobalamin synthesis protein
EB_RS06530	COG1028	Short-chain dehydrogenase reductase Sdr
EB_RS06570	COG3039	Transposase
EB_RS06580	COG2197	response regulator
EB_RS06595	COG2076	Multidrug Resistance protein
EB_RS06620	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EB_RS06630	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
EB_RS06635	COG0145	ligase activity
EB_RS06640	COG4647	ligase activity
EB_RS06645	COG0145	ligase activity
EB_RS06710	COG2003	Belongs to the UPF0758 family
EB_RS06770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EB_RS06785	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EB_RS06835	COG0776	regulation of translation
EB_RS06990	COG0582	viral genome integration into host DNA
EB_RS06995	COG1484	DNA-dependent DNA replication
EB_RS07005	COG0582	viral genome integration into host DNA
EB_RS07085	COG2003	Belongs to the UPF0758 family
EB_RS07120	COG3093	addiction module antidote protein HigA
EB_RS07135	COG0488	(ABC) transporter
EB_RS07140	COG0675	Transposase, IS605 OrfB family
EB_RS07155	COG0697	spore germination
EB_RS07165	COG0189	ligase activity
EB_RS07200	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EB_RS07215	COG4657	Part of a membrane complex involved in electron transport
EB_RS07220	COG2878	Part of a membrane complex involved in electron transport
EB_RS07225	COG4656	Part of a membrane complex involved in electron transport
EB_RS07230	COG4658	electron transport chain
EB_RS07245	COG2914	Belongs to the UPF0125 (RnfH) family
EB_RS07265	COG4191	Histidine kinase
EB_RS07275	COG5265	(ABC) transporter
EB_RS07310	COG0583	DNA-binding transcription factor activity
EB_RS07315	COG0730	response to heat
EB_RS07330	COG0175	sulfate reduction
EB_RS07335	COG0175	sulfate reduction
EB_RS07340	COG2895	sulfate adenylyltransferase (ATP) activity
EB_RS07345	COG2070	2-Nitropropane dioxygenase
EB_RS07355	COG0330	HflC and HflK could
EB_RS07370	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EB_RS07375	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EB_RS07385	COG0824	Thioesterase
EB_RS07405	COG0823	Involved in the tonB-independent uptake of proteins
EB_RS07415	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EB_RS07420	COG0602	queuosine metabolic process
EB_RS07425	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EB_RS07445	COG1484	DNA-dependent DNA replication
EB_RS07485	COG4584	PFAM Integrase catalytic
EB_RS07485	COG2390	Transcriptional regulator
EB_RS07490	COG1484	DNA-dependent DNA replication
EB_RS07500	COG3756	Protein conserved in bacteria
EB_RS07525	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
EB_RS07530	COG0582	viral genome integration into host DNA
EB_RS07545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EB_RS07550	COG1194	a g-specific adenine glycosylase
EB_RS07570	COG0559	Belongs to the binding-protein-dependent transport system permease family
EB_RS07575	COG2860	membrane
EB_RS07580	COG1970	mechanosensitive ion channel activity
EB_RS07585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EB_RS07590	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EB_RS07605	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EB_RS07610	COG1074	ATP-dependent DNA helicase activity
EB_RS07615	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EB_RS07650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EB_RS07655	COG0569	domain protein
EB_RS07670	COG3383	formate dehydrogenase (NAD+) activity
EB_RS07715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EB_RS07780	COG0826	peptidase U32
EB_RS07790	COG0488	(ABC) transporter
EB_RS07795	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EB_RS07795	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EB_RS07800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EB_RS07805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EB_RS07830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EB_RS07835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EB_RS07835	COG2813	Specifically methylates the guanine in position
EB_RS07845	COG2814	Major facilitator Superfamily
EB_RS07855	COG0288	reversible hydration of carbon dioxide
EB_RS07860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EB_RS07865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EB_RS07875	COG0569	domain protein
EB_RS07880	COG2204	response regulator
EB_RS07885	COG5000	phosphorelay sensor kinase activity
EB_RS07910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EB_RS07915	COG0706	membrane insertase activity
EB_RS07920	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EB_RS07925	COG0594	ribonuclease P activity
EB_RS07930	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EB_RS07935	COG0592	DNA-directed DNA polymerase activity
EB_RS07950	COG1944	ATP diphosphatase activity
EB_RS07980	COG0110	maltose O-acetyltransferase activity
EB_RS07985	COG0405	Gamma-glutamyltransferase
EB_RS08000	COG0393	Putative heavy-metal-binding
EB_RS08005	COG0488	(ABC) transporter
EB_RS08010	COG1959	2 iron, 2 sulfur cluster binding
EB_RS08015	COG3278	Belongs to the heme-copper respiratory oxidase family
EB_RS08040	COG3108	Peptidase M15
EB_RS08045	COG2989	Protein conserved in bacteria
EB_RS08080	COG1475	DNA binding
EB_RS08105	COG1192	Involved in chromosome partitioning
EB_RS08110	COG0357	Ribosomal RNA small subunit methyltransferase G
EB_RS08115	COG0445	tRNA wobble uridine modification
EB_RS08150	COG0437	4 iron, 4 sulfur cluster binding
EB_RS08155	COG3383	formate dehydrogenase (NAD+) activity
EB_RS08155	COG0243	molybdopterin cofactor binding
EB_RS08190	COG0746	molybdenum cofactor guanylyltransferase activity
EB_RS08200	COG1763	Mo-molybdopterin cofactor biosynthetic process
EB_RS08210	COG0501	Belongs to the peptidase M48B family
EB_RS08215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EB_RS08220	COG0242	peptide deformylase activity
EB_RS08225	COG1652	LysM domain
EB_RS08230	COG0758	DNA mediated transformation
EB_RS08235	COG2922	Belongs to the Smg family
EB_RS08255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EB_RS08260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EB_RS08270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EB_RS08280	COG1187	pseudouridine synthase activity
EB_RS08290	COG2974	May be involved in recombination
EB_RS08300	COG0784	Response regulator, receiver
EB_RS08315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EB_RS08320	COG1960	acyl-CoA dehydrogenase activity
EB_RS08325	COG0583	DNA-binding transcription factor activity
EB_RS08345	COG0356	it plays a direct role in the translocation of protons across the membrane
EB_RS08355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EB_RS08360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EB_RS08365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EB_RS08370	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EB_RS08375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EB_RS08380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EB_RS08395	COG2226	methyltransferase
EB_RS08405	COG0745	RESPONSE REGULATOR receiver
EB_RS08425	COG0121	glutamine amidotransferase
EB_RS08430	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EB_RS08435	COG0154	amidase activity
EB_RS08440	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EB_RS08445	COG1077	Cell shape determining protein MreB Mrl
EB_RS08460	COG0768	penicillin binding
EB_RS08465	COG0772	Belongs to the SEDS family
EB_RS08475	COG1686	Belongs to the peptidase S11 family
EB_RS08485	COG2921	Belongs to the UPF0250 family
EB_RS08490	COG0321	lipoyl(octanoyl) transferase activity
EB_RS08495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EB_RS08535	COG4566	intracellular signal transduction
EB_RS08545	COG3245	cytochrome
EB_RS08550	COG1652	LysM domain
EB_RS08575	COG0587	DNA-directed DNA polymerase activity
EB_RS08590	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EB_RS08595	COG2258	MOSC domain
EB_RS08610	COG2733	membrane
EB_RS08650	COG0420	3'-5' exonuclease activity
EB_RS08665	COG1063	alcohol dehydrogenase
EB_RS08670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EB_RS08700	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EB_RS08715	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EB_RS08725	COG0517	IMP dehydrogenase activity
EB_RS08730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EB_RS08730	COG0574	Belongs to the PEP-utilizing enzyme family
EB_RS08750	COG0674	pyruvate-flavodoxin oxidoreductase activity
EB_RS08750	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EB_RS08755	COG1013	pyruvate-flavodoxin oxidoreductase activity
EB_RS08760	COG0004	ammonium transporteR
EB_RS08765	COG0347	Belongs to the P(II) protein family
EB_RS08780	COG0606	chelatase, subunit chli
EB_RS08785	COG2814	Major facilitator Superfamily
EB_RS08850	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EB_RS08865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EB_RS08885	COG1477	protein flavinylation
EB_RS08940	COG4372	Transposase
EB_RS08965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EB_RS08990	COG3876	Protein conserved in bacteria
EB_RS09010	COG4772	TonB-dependent receptor
EB_RS09020	COG0861	Integral membrane protein TerC family
EB_RS09030	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EB_RS09060	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EB_RS09065	COG1518	maintenance of DNA repeat elements
EB_RS09140	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EB_RS09180	COG1368	sulfuric ester hydrolase activity
EB_RS09190	COG0642	Histidine kinase
EB_RS09195	COG0708	Exodeoxyribonuclease III
EB_RS09200	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EB_RS09210	COG0243	molybdopterin cofactor binding
EB_RS09215	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EB_RS09220	COG2161	toxin-antitoxin pair type II binding
EB_RS09225	COG4115	mRNA cleavage
EB_RS09245	COG1484	DNA-dependent DNA replication
EB_RS09275	COG4691	Plasmid stability protein
EB_RS09310	COG1238	metal cluster binding
EB_RS09320	COG0037	tRNA processing
EB_RS09345	COG0625	glutathione transferase activity
EB_RS09355	COG0617	tRNA 3'-terminal CCA addition
EB_RS09375	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EB_RS09380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EB_RS09385	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EB_RS09395	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EB_RS09400	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EB_RS09410	COG2137	regulation of response to DNA damage stimulus
EB_RS09415	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EB_RS09420	COG1546	Belongs to the CinA family
EB_RS09425	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EB_RS09430	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EB_RS09445	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EB_RS09495	COG0318	PFAM AMP-dependent synthetase and ligase
EB_RS09525	COG1538	Outer membrane efflux protein
EB_RS09530	COG1566	PFAM secretion protein HlyD family protein
EB_RS09575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EB_RS09585	COG0788	formyltetrahydrofolate deformylase activity
EB_RS09590	COG0443	Heat shock 70 kDa protein
EB_RS09595	COG1278	Cold shock
EB_RS09610	COG1305	Transglutaminase-like
EB_RS09615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EB_RS09620	COG3045	CreA protein
EB_RS09635	COG0484	heat shock protein binding
EB_RS09640	COG0194	GDP metabolic process
EB_RS09645	COG1758	RNA polymerase activity
EB_RS09650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EB_RS09660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EB_RS09660	COG1199	ATP-dependent helicase activity
EB_RS09670	COG3850	Histidine kinase
EB_RS09675	COG2197	response regulator
EB_RS09685	COG4133	protoheme IX ABC transporter activity
EB_RS09705	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EB_RS09715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EB_RS09720	COG3088	subunit of a heme lyase
EB_RS09735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EB_RS09740	COG1368	sulfuric ester hydrolase activity
EB_RS09745	COG3162	membrane
EB_RS09770	COG1024	Enoyl-CoA hydratase
EB_RS09775	COG1250	3-hydroxyacyl-CoA dehydrogenase
EB_RS09780	COG2050	protein possibly involved in aromatic compounds catabolism
EB_RS09790	COG3396	Phenylacetate-CoA oxygenase
EB_RS09795	COG3460	Phenylacetate-CoA oxygenase
EB_RS09800	COG3396	Phenylacetate-CoA oxygenase
EB_RS09805	COG2151	metal-sulfur cluster biosynthetic enzyme
EB_RS09810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EB_RS09840	COG1902	pentaerythritol trinitrate reductase activity
EB_RS09850	COG0513	Belongs to the DEAD box helicase family
EB_RS09855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EB_RS09860	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EB_RS09875	COG4232	protein-disulfide reductase activity
EB_RS09880	COG1324	tolerance protein
EB_RS09885	COG0589	response to stress
EB_RS09890	COG0861	Integral membrane protein TerC family
EB_RS09900	COG1131	(ABC) transporter
EB_RS09905	COG0625	glutathione transferase activity
EB_RS09925	COG3154	lipid carrier protein
EB_RS09930	COG0826	peptidase U32
EB_RS09935	COG0826	peptidase U32
EB_RS09950	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EB_RS09970	COG0252	asparaginase activity
EB_RS09975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EB_RS09985	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EB_RS09990	COG0018	arginyl-trna synthetase
EB_RS10005	COG2902	Dehydrogenase
EB_RS10010	COG3158	transport of potassium into the cell
EB_RS10015	COG0686	Belongs to the AlaDH PNT family
EB_RS10020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EB_RS10030	COG3243	poly(R)-hydroxyalkanoic acid synthase
EB_RS10035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EB_RS10040	COG0789	Transcriptional regulator
EB_RS10045	COG0288	reversible hydration of carbon dioxide
EB_RS10050	COG0183	Belongs to the thiolase family
EB_RS10055	COG1960	acyl-CoA dehydrogenase activity
EB_RS10060	COG1024	Enoyl-CoA hydratase
EB_RS10080	COG1660	Displays ATPase and GTPase activities
EB_RS10095	COG0604	alcohol dehydrogenase
EB_RS10100	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EB_RS10110	COG2204	response regulator
EB_RS10120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EB_RS10140	COG0217	transcriptional regulatory protein
EB_RS10150	COG1555	photosystem II stabilization
EB_RS10150	COG1596	polysaccharide export
EB_RS10160	COG0513	Belongs to the DEAD box helicase family
EB_RS10170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EB_RS10175	COG1492	cobalamin metabolic process
EB_RS10180	COG1024	Enoyl-CoA hydratase
EB_RS10185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EB_RS10235	COG4964	Belongs to the GSP D family
EB_RS10275	COG2201	protein-glutamate methylesterase activity
EB_RS10280	COG2197	response regulator
EB_RS10290	COG0114	fumarate hydratase activity
EB_RS10295	COG1802	Transcriptional regulator
EB_RS10300	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EB_RS10300	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EB_RS10310	COG1703	isobutyryl-CoA mutase activity
EB_RS10315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EB_RS10320	COG4770	biotin carboxylase activity
EB_RS10330	COG2321	neutral zinc metallopeptidase
EB_RS10340	COG2207	Transcriptional regulator
EB_RS10345	COG2807	transmembrane transport
EB_RS10370	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EB_RS10370	COG1703	isobutyryl-CoA mutase activity
EB_RS10370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EB_RS10385	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
EB_RS10390	COG1703	isobutyryl-CoA mutase activity
EB_RS10390	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EB_RS10390	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EB_RS10410	COG4584	PFAM Integrase catalytic
EB_RS10415	COG1484	DNA-dependent DNA replication
EB_RS10435	COG0586	Pfam SNARE associated Golgi protein
EB_RS10445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EB_RS10455	COG5002	protein histidine kinase activity
EB_RS10455	COG2205	protein histidine kinase activity
EB_RS10455	COG0784	Response regulator, receiver
EB_RS10465	COG2197	response regulator
EB_RS10470	COG0277	FAD linked oxidase domain protein
EB_RS10475	COG1522	sequence-specific DNA binding
EB_RS10495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EB_RS10505	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EB_RS10515	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EB_RS10520	COG0081	regulation of translation
EB_RS10525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EB_RS10530	COG0222	ribosome binding
EB_RS10535	COG0085	RNA polymerase activity
EB_RS10540	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EB_RS10545	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EB_RS10550	COG0049	tRNA binding
EB_RS10555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EB_RS10560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EB_RS10565	COG0051	transcription antitermination factor activity, RNA binding
EB_RS10570	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EB_RS10575	COG0088	Forms part of the polypeptide exit tunnel
EB_RS10580	COG0089	rRNA binding
EB_RS10585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EB_RS10590	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EB_RS10595	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EB_RS10600	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EB_RS10605	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EB_RS10610	COG0255	Belongs to the universal ribosomal protein uL29 family
EB_RS10615	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EB_RS10620	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EB_RS10625	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EB_RS10630	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EB_RS10635	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EB_RS10640	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EB_RS10645	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EB_RS10650	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EB_RS10655	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EB_RS10660	COG1841	ribosomal large subunit assembly
EB_RS10665	COG0200	Binds to the 23S rRNA
EB_RS10670	COG0201	protein transport
EB_RS10680	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EB_RS10685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EB_RS10690	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EB_RS10695	COG0202	RNA polymerase activity
EB_RS10700	COG0203	ribosomal protein L17
EB_RS10705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EB_RS10715	COG2814	Major facilitator Superfamily
EB_RS10720	COG0629	single-stranded DNA binding
EB_RS10725	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EB_RS10740	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EB_RS10765	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EB_RS10770	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EB_RS10780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EB_RS10785	COG2084	Dehydrogenase
EB_RS10790	COG2084	Dehydrogenase
EB_RS10800	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EB_RS10805	COG0436	Aminotransferase
EB_RS10830	COG3744	PilT protein domain protein
EB_RS10870	COG2814	Major facilitator Superfamily
EB_RS10900	COG0247	lactate metabolic process
EB_RS10905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EB_RS10920	COG1032	radical SAM domain protein
EB_RS10945	COG4772	TonB-dependent receptor
EB_RS10950	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EB_RS10960	COG1560	Kdo2-lipid A biosynthetic process
EB_RS10965	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EB_RS10980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EB_RS10990	COG2255	four-way junction helicase activity
EB_RS10995	COG0632	four-way junction helicase activity
EB_RS11010	COG0424	maF-like protein
EB_RS11015	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EB_RS11020	COG0799	negative regulation of ribosome biogenesis
EB_RS11025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EB_RS11040	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EB_RS11060	COG1115	amino acid carrier protein
EB_RS11065	COG2192	nodulation
EB_RS11070	COG1215	transferase activity, transferring glycosyl groups
EB_RS11070	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EB_RS11090	COG1132	(ABC) transporter
EB_RS11105	COG0438	transferase activity, transferring glycosyl groups
EB_RS11120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EB_RS11135	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EB_RS11150	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EB_RS11165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EB_RS11170	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EB_RS11180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EB_RS11180	COG1648	precorrin-2 dehydrogenase activity
EB_RS11185	COG1797	cobyrinic acid a,c-diamide synthase activity
EB_RS11190	COG0778	Nitroreductase
EB_RS11195	COG0583	DNA-binding transcription factor activity
EB_RS11205	COG0668	transmembrane transport
EB_RS11215	COG0741	lytic transglycosylase activity
EB_RS11220	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
EB_RS11225	COG0281	malic enzyme
EB_RS11225	COG0280	phosphate acetyltransferase
EB_RS11235	COG1686	Belongs to the peptidase S11 family
EB_RS11240	COG1414	Transcriptional regulator
EB_RS11245	COG0247	lactate metabolic process
EB_RS11250	COG1139	Iron-sulfur cluster binding protein
EB_RS11255	COG1556	Lactate utilization protein
EB_RS11265	COG1187	pseudouridine synthase activity
EB_RS11275	COG0577	efflux transmembrane transporter activity
EB_RS11275	COG1136	(ABC) transporter
EB_RS11295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EB_RS11300	COG0668	transmembrane transport
EB_RS11305	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EB_RS11325	COG1643	Atp-dependent helicase
EB_RS11330	COG0360	Binds together with S18 to 16S ribosomal RNA
EB_RS11335	COG2965	DNA replication, synthesis of RNA primer
EB_RS11340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EB_RS11345	COG0359	binds to the 23S rRNA
EB_RS11350	COG0305	Participates in initiation and elongation during chromosome replication
EB_RS11380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EB_RS11405	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EB_RS11410	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EB_RS11415	COG0237	dephospho-CoA kinase activity
EB_RS11425	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
EB_RS11430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EB_RS11445	COG3852	Histidine kinase
EB_RS11455	COG0174	glutamine synthetase
EB_RS11465	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EB_RS11470	COG3568	Endonuclease Exonuclease Phosphatase
EB_RS11485	COG1028	Short-chain dehydrogenase reductase Sdr
EB_RS11490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EB_RS11510	COG0012	GTP binding
EB_RS11515	COG0583	DNA-binding transcription factor activity
EB_RS11525	COG0670	Belongs to the BI1 family
EB_RS11530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EB_RS11535	COG1253	flavin adenine dinucleotide binding
EB_RS11540	COG0825	malonyl-CoA metabolic process
EB_RS11545	COG0037	tRNA processing
EB_RS11550	COG4566	intracellular signal transduction
EB_RS11575	COG2423	ornithine cyclodeaminase activity
EB_RS11585	COG5212	phosphodiesterase
EB_RS11590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EB_RS11595	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EB_RS11600	COG0546	phosphoglycolate phosphatase activity
EB_RS11615	COG2824	Alkylphosphonate utilization operon protein PhnA
EB_RS11625	COG3260	NADH ubiquinone oxidoreductase 20
EB_RS11630	COG0649	NAD binding
EB_RS11635	COG0651	ATP synthesis coupled electron transport
EB_RS11645	COG0650	Formate hydrogenlyase subunit 4
EB_RS11650	COG0651	ATP synthesis coupled electron transport
EB_RS11670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EB_RS11675	COG0134	indole-3-glycerol-phosphate synthase activity
EB_RS11685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EB_RS11695	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EB_RS11710	COG0514	ATP-dependent DNA helicase (RecQ)
EB_RS11715	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EB_RS11725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EB_RS11765	COG0109	protoheme IX farnesyltransferase activity
EB_RS11770	COG1999	signal sequence binding
EB_RS11775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EB_RS11800	COG0489	protein tyrosine kinase activity
EB_RS11810	COG3267	Type II secretory pathway component ExeA
EB_RS11810	COG3409	Peptidoglycan-binding domain 1 protein
EB_RS11835	COG0438	transferase activity, transferring glycosyl groups
EB_RS11840	COG0367	asparagine synthase
EB_RS11845	COG0438	transferase activity, transferring glycosyl groups
EB_RS11850	COG0367	asparagine synthase
EB_RS11875	COG0438	transferase activity, transferring glycosyl groups
EB_RS11930	COG0318	PFAM AMP-dependent synthetase and ligase
EB_RS11955	COG1216	Glycosyl transferase, family 2
EB_RS12015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EB_RS12020	COG1960	acyl-CoA dehydrogenase activity
EB_RS12030	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EB_RS12035	COG0071	Belongs to the small heat shock protein (HSP20) family
EB_RS12045	COG0494	nUDIX hydrolase
EB_RS12060	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EB_RS12090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EB_RS12095	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EB_RS12115	COG0346	lactoylglutathione lyase activity
EB_RS12125	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EB_RS12150	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EB_RS12155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EB_RS12160	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EB_RS12175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EB_RS12185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EB_RS12190	COG1466	dna polymerase III delta subunit
EB_RS12200	COG0495	leucyl-tRNA aminoacylation
EB_RS12210	COG0210	DNA helicase
EB_RS12215	COG1192	Involved in chromosome partitioning
EB_RS12220	COG0281	malic enzyme
EB_RS12220	COG0280	phosphate acetyltransferase
EB_RS12250	COG0450	alkyl hydroperoxide reductase
EB_RS12255	COG1254	Belongs to the acylphosphatase family
EB_RS12260	COG0659	secondary active sulfate transmembrane transporter activity
EB_RS12265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EB_RS12265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EB_RS12275	COG0489	protein tyrosine kinase activity
EB_RS12280	COG0717	Belongs to the dCTP deaminase family
EB_RS12295	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EB_RS12325	COG2030	dehydratase
EB_RS12340	COG1469	GTP cyclohydrolase I activity
EB_RS12345	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EB_RS12350	COG0142	geranyltranstransferase activity
EB_RS12365	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EB_RS12370	COG1047	Peptidyl-prolyl cis-trans
EB_RS12375	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EB_RS12380	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EB_RS12385	COG0196	riboflavin kinase activity
EB_RS12390	COG0860	N-Acetylmuramoyl-L-alanine amidase
EB_RS12395	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EB_RS12400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EB_RS12405	COG1028	Short-chain dehydrogenase reductase Sdr
EB_RS12420	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EB_RS12425	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EB_RS12450	COG2224	Isocitrate lyase
EB_RS12455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EB_RS12460	COG0542	response to heat
EB_RS12465	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EB_RS12470	COG1278	Cold shock
EB_RS12475	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EB_RS12480	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EB_RS12495	COG0277	FAD linked oxidase domain protein
EB_RS12500	COG0277	FAD linked oxidase domain protein
EB_RS12505	COG0247	lactate metabolic process
EB_RS12515	COG0598	Magnesium transport protein CorA
EB_RS12525	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EB_RS12540	COG0513	Belongs to the DEAD box helicase family
EB_RS12545	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
EB_RS12550	COG1653	transport
EB_RS12555	COG0584	glycerophosphoryl diester phosphodiesterase
EB_RS12560	COG0142	geranyltranstransferase activity
EB_RS12580	COG1595	DNA-templated transcription, initiation
EB_RS12620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EB_RS12650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EB_RS12650	COG2010	Cytochrome c
EB_RS12665	COG4948	Mandelate Racemase Muconate Lactonizing
EB_RS12680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EB_RS12685	COG0765	amino acid transport
EB_RS12690	COG0765	amino acid transport
EB_RS12695	COG1126	abc transporter atp-binding protein
EB_RS12700	COG0517	IMP dehydrogenase activity
EB_RS12700	COG0516	GMP reductase activity
EB_RS12720	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EB_RS12740	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EB_RS12755	COG0674	pyruvate-flavodoxin oxidoreductase activity
EB_RS12755	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EB_RS12760	COG1013	pyruvate-flavodoxin oxidoreductase activity
EB_RS12770	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EB_RS12770	COG0517	IMP dehydrogenase activity
EB_RS12770	COG0617	tRNA 3'-terminal CCA addition
EB_RS12785	COG0626	cystathionine gamma-synthase activity
EB_RS12810	COG0004	ammonium transporteR
EB_RS12815	COG0697	spore germination
EB_RS12820	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EB_RS12825	COG3193	protein, possibly involved in utilization of glycolate and propanediol
EB_RS12835	COG3622	Belongs to the hyi family
EB_RS12850	COG1454	alcohol dehydrogenase
EB_RS12855	COG1012	belongs to the aldehyde dehydrogenase family
EB_RS12860	COG3284	Transcriptional regulator
EB_RS12880	COG1294	oxidase, subunit
EB_RS12885	COG1271	oxidase subunit
EB_RS12890	COG2259	Doxx family
EB_RS12895	COG2059	Chromate
EB_RS12930	COG1960	acyl-CoA dehydrogenase activity
EB_RS12935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EB_RS12940	COG4770	biotin carboxylase activity
EB_RS12945	COG0318	PFAM AMP-dependent synthetase and ligase
EB_RS12960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EB_RS12965	COG0402	S-adenosylhomocysteine deaminase activity
EB_RS12980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EB_RS12985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EB_RS13020	COG0145	ligase activity
EB_RS13025	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
EB_RS13030	COG4647	ligase activity
EB_RS13055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EB_RS13070	COG3284	Transcriptional regulator
EB_RS13085	COG0564	pseudouridine synthase activity
EB_RS13100	COG3243	poly(R)-hydroxyalkanoic acid synthase
EB_RS13105	COG1028	Short-chain dehydrogenase reductase Sdr
EB_RS13115	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
EB_RS13120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EB_RS13125	COG1752	Esterase of the alpha-beta hydrolase superfamily
EB_RS13130	COG0277	FAD linked oxidase domain protein
EB_RS13165	COG1250	3-hydroxyacyl-CoA dehydrogenase
EB_RS13170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EB_RS13180	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EB_RS13190	COG0318	PFAM AMP-dependent synthetase and ligase
EB_RS13195	COG0028	Belongs to the TPP enzyme family
EB_RS13200	COG0440	acetolactate synthase activity
EB_RS13205	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EB_RS13210	COG2814	Major facilitator Superfamily
EB_RS13220	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EB_RS13225	COG0066	3-isopropylmalate dehydratase activity
EB_RS13230	COG0473	3-isopropylmalate dehydrogenase activity
EB_RS13235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EB_RS13250	COG0101	tRNA pseudouridine synthase activity
EB_RS13255	COG0135	phosphoribosylanthranilate isomerase activity
EB_RS13260	COG0133	tryptophan synthase activity
EB_RS13265	COG0159	tryptophan synthase activity
EB_RS13270	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EB_RS13275	COG0285	dihydrofolate synthase activity
EB_RS13285	COG1286	toxin biosynthetic process
EB_RS13300	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EB_RS13305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EB_RS13315	COG0215	cysteine-tRNA ligase activity
EB_RS13320	COG0484	heat shock protein binding
EB_RS13325	COG0443	Heat shock 70 kDa protein
EB_RS13330	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EB_RS13335	COG2815	serine threonine protein kinase
EB_RS13335	COG0515	serine threonine protein kinase
EB_RS13340	COG1950	PFAM Membrane protein of
EB_RS13345	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EB_RS13350	COG1420	regulation of RNA biosynthetic process
EB_RS13355	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EB_RS13360	COG0497	DNA recombination
EB_RS13365	COG0735	belongs to the Fur family
EB_RS13370	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EB_RS13375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EB_RS13380	COG0505	Belongs to the CarA family
EB_RS13385	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EB_RS13390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EB_RS13400	COG1534	Rna-binding protein
EB_RS13405	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EB_RS13410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EB_RS13420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EB_RS13425	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EB_RS13430	COG0573	inorganic phosphate transmembrane transporter activity
EB_RS13435	COG0573	inorganic phosphate transmembrane transporter activity
EB_RS13440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EB_RS13445	COG0149	triose-phosphate isomerase activity
EB_RS13460	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EB_RS13465	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EB_RS13470	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EB_RS13475	COG0649	NAD binding
EB_RS13480	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EB_RS13490	COG1034	ATP synthesis coupled electron transport
EB_RS13490	COG1034	ATP synthesis coupled electron transport
EB_RS13495	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EB_RS13500	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EB_RS13510	COG0713	ATP synthesis coupled electron transport
EB_RS13525	COG1007	ATP synthesis coupled electron transport
EB_RS13540	COG1230	cation diffusion facilitator family transporter
EB_RS13570	COG2951	lytic endotransglycosylase activity
EB_RS13580	COG0326	Molecular chaperone. Has ATPase activity
EB_RS13600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EB_RS13620	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EB_RS13635	COG4658	electron transport chain
EB_RS13645	COG2878	Part of a membrane complex involved in electron transport
EB_RS13650	COG4657	Part of a membrane complex involved in electron transport
EB_RS13655	COG0167	dihydroorotate dehydrogenase activity
EB_RS13660	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EB_RS13665	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EB_RS13670	COG3842	ATPase activity
EB_RS13675	COG1178	ABC-type Fe3 transport system permease component
EB_RS13750	COG1840	ABC-type Fe3 transport system, periplasmic component
EB_RS13760	COG0791	NLP P60 protein
EB_RS13820	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EB_RS13825	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EB_RS13835	COG0436	Aminotransferase
EB_RS13865	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EB_RS13865	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EB_RS13870	COG2719	SpoVR family
EB_RS13875	COG2718	Belongs to the UPF0229 family
EB_RS13880	COG2766	serine protein kinase
EB_RS13885	COG0544	peptidyl-prolyl cis-trans isomerase activity
EB_RS13890	COG0740	serine-type endopeptidase activity
EB_RS13895	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EB_RS13900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EB_RS13920	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EB_RS13935	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EB_RS13950	COG0640	Transcriptional regulator
EB_RS13970	COG0798	PFAM Bile acid sodium symporter
EB_RS13985	COG2414	aldehyde ferredoxin oxidoreductase
EB_RS13990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EB_RS14015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EB_RS14020	COG0583	DNA-binding transcription factor activity
EB_RS14025	COG0702	epimerase
EB_RS14030	COG3038	cytochrome b561
EB_RS14060	COG2982	Protein involved in outer membrane biogenesis
EB_RS14085	COG2814	Major facilitator Superfamily
EB_RS14090	COG0583	DNA-binding transcription factor activity
EB_RS14105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EB_RS14115	COG0617	tRNA 3'-terminal CCA addition
EB_RS14115	COG3620	sequence-specific DNA binding
EB_RS14115	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EB_RS14135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EB_RS14140	COG1570	exodeoxyribonuclease VII activity
EB_RS14145	COG0811	peptide transport
EB_RS14150	COG0848	biopolymer transport protein
EB_RS14155	COG1663	tetraacyldisaccharide 4'-kinase activity
EB_RS14160	COG2835	tetraacyldisaccharide 4'-kinase activity
EB_RS14165	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EB_RS14170	COG0563	adenylate kinase activity
EB_RS14190	COG0268	Binds directly to 16S ribosomal RNA
EB_RS14200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EB_RS14205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EB_RS14210	COG0137	argininosuccinate synthase activity
EB_RS14220	COG3123	guanosine phosphorylase activity
EB_RS14225	COG1666	GTP binding
EB_RS14275	COG3275	phosphorelay sensor kinase activity
EB_RS14290	COG0494	nUDIX hydrolase
EB_RS14305	COG2217	Heavy metal translocating P-type atpase
EB_RS14315	COG3278	Belongs to the heme-copper respiratory oxidase family
EB_RS14330	COG2010	Cytochrome c
EB_RS14355	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EB_RS14360	COG3243	poly(R)-hydroxyalkanoic acid synthase
EB_RS14365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EB_RS14385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EB_RS14390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EB_RS14400	COG2217	Heavy metal translocating P-type atpase
EB_RS14435	COG2409	Drug exporters of the RND superfamily
EB_RS14470	COG1132	(ABC) transporter
EB_RS14485	COG0826	peptidase U32
EB_RS14490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EB_RS14500	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EB_RS14505	COG0183	Belongs to the thiolase family
EB_RS14510	COG1162	GTPase activity
EB_RS14515	COG0501	Belongs to the peptidase M48B family
EB_RS14520	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EB_RS14525	COG0166	Belongs to the GPI family
EB_RS14535	COG0254	rRNA binding
EB_RS14575	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EB_RS14585	COG4133	protoheme IX ABC transporter activity
EB_RS14610	COG1484	DNA-dependent DNA replication
EB_RS14630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EB_RS14635	COG3318	Belongs to the UPF0149 family
EB_RS14635	COG3012	SEC-C Motif Domain Protein
EB_RS14660	COG3012	SEC-C Motif Domain Protein
EB_RS14665	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EB_RS14680	COG0861	Integral membrane protein TerC family
EB_RS14685	COG0367	asparagine synthase
EB_RS14690	COG0189	ligase activity
EB_RS14690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EB_RS14695	COG1363	Peptidase, m42
EB_RS14710	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EB_RS14750	COG0587	DNA-directed DNA polymerase activity
EB_RS14775	COG1024	Enoyl-CoA hydratase
EB_RS14780	COG1028	Short-chain dehydrogenase reductase Sdr
EB_RS14805	COG0411	ABC transporter
EB_RS14815	COG2814	Major facilitator Superfamily
EB_RS14830	COG0318	PFAM AMP-dependent synthetase and ligase
EB_RS14835	COG1024	Enoyl-CoA hydratase
EB_RS14840	COG0183	Belongs to the thiolase family
EB_RS14850	COG1960	acyl-CoA dehydrogenase activity
EB_RS14900	COG1484	DNA-dependent DNA replication
EB_RS14930	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EB_RS14955	COG2204	response regulator
EB_RS14975	COG1012	belongs to the aldehyde dehydrogenase family
EB_RS14990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EB_RS14995	COG3327	negative regulation of DNA-templated transcription, initiation
EB_RS15000	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EB_RS15005	COG0243	molybdopterin cofactor binding
EB_RS15005	COG0243	molybdopterin cofactor binding
EB_RS15065	COG1376	ErfK ybiS ycfS ynhG family protein
EB_RS15085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EB_RS15090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EB_RS15105	COG0084	hydrolase, TatD family'
EB_RS15120	COG1473	amidohydrolase
EB_RS15125	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EB_RS15135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EB_RS15145	COG1067	ATP-dependent peptidase activity
EB_RS15175	COG0556	nucleotide-excision repair
EB_RS15180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EB_RS15185	COG1530	ribonuclease E activity
EB_RS15195	COG0546	phosphoglycolate phosphatase activity
EB_RS15205	COG0424	maF-like protein
EB_RS15215	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EB_RS15220	COG0416	fatty acid biosynthetic process
EB_RS15225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EB_RS15240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EB_RS15255	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EB_RS15280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EB_RS15320	COG4695	Portal protein
EB_RS15340	COG4372	Transposase
EB_RS15360	COG1484	DNA-dependent DNA replication
EB_RS15405	COG2390	Transcriptional regulator
EB_RS15405	COG4584	PFAM Integrase catalytic
EB_RS15410	COG1484	DNA-dependent DNA replication
EB_RS15425	COG4372	Transposase
EB_RS15460	COG0582	viral genome integration into host DNA
EB_RS15465	COG0481	GTPase activity
EB_RS15470	COG0681	Belongs to the peptidase S26 family
EB_RS15480	COG0571	ribonuclease III activity
EB_RS15485	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EB_RS15490	COG1381	Involved in DNA repair and RecF pathway recombination
EB_RS15495	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EB_RS15500	COG0736	holo-[acyl-carrier-protein] synthase activity
EB_RS15505	COG1472	Belongs to the glycosyl hydrolase 3 family
EB_RS15510	COG0322	excinuclease ABC activity
EB_RS15530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EB_RS15535	COG0569	domain protein
EB_RS15585	COG0438	transferase activity, transferring glycosyl groups
EB_RS15655	COG0583	DNA-binding transcription factor activity
EB_RS15665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EB_RS15675	COG0179	Fumarylacetoacetate (FAA) hydrolase
EB_RS15680	COG1024	Enoyl-CoA hydratase
EB_RS15695	COG0243	molybdopterin cofactor binding
EB_RS15700	COG0437	4 iron, 4 sulfur cluster binding
EB_RS15720	COG1960	acyl-CoA dehydrogenase activity
EB_RS15730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EB_RS15745	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EB_RS15765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EB_RS15775	COG1802	Transcriptional regulator
EB_RS15785	COG1960	acyl-CoA dehydrogenase activity
EB_RS15790	COG1960	acyl-CoA dehydrogenase activity
EB_RS15795	COG1028	Short-chain dehydrogenase reductase Sdr
EB_RS15800	COG2030	dehydratase
EB_RS15820	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EB_RS15825	COG0163	prenyltransferase activity
EB_RS15835	COG0028	Belongs to the TPP enzyme family
EB_RS15875	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EB_RS15880	COG2814	Major facilitator Superfamily
EB_RS15890	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EB_RS15895	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EB_RS15900	COG4585	Histidine kinase
EB_RS15905	COG2197	response regulator
EB_RS15910	COG3396	Phenylacetate-CoA oxygenase
EB_RS15915	COG3460	Phenylacetate-CoA oxygenase
EB_RS15920	COG3396	Phenylacetate-CoA oxygenase
EB_RS15925	COG2151	metal-sulfur cluster biosynthetic enzyme
EB_RS15930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EB_RS15945	COG0183	Belongs to the thiolase family
EB_RS15950	COG1024	Enoyl-CoA hydratase
EB_RS15975	COG0513	Belongs to the DEAD box helicase family
EB_RS15980	COG0010	Belongs to the arginase family
EB_RS15985	COG1228	amidohydrolase
EB_RS15990	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EB_RS15995	COG2986	histidine ammonia-lyase
EB_RS16005	COG4585	Histidine kinase
EB_RS16010	COG2197	response regulator
EB_RS16025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EB_RS16055	COG5433	transposase activity
EB_RS16065	COG0511	ligase activity, forming carbon-carbon bonds
EB_RS16070	COG0439	Biotin carboxylase
EB_RS16100	COG1028	Short-chain dehydrogenase reductase Sdr
EB_RS16105	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EB_RS16125	COG0183	Belongs to the thiolase family
EB_RS16130	COG1611	Belongs to the LOG family
EB_RS16145	COG1704	LemA family
EB_RS16150	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EB_RS16155	COG3047	cAMP biosynthetic process
EB_RS16175	COG1136	(ABC) transporter
EB_RS16200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EB_RS16210	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EB_RS16230	COG1028	Short-chain dehydrogenase reductase Sdr
EB_RS16240	COG0446	pyridine nucleotide-disulphide oxidoreductase
EB_RS16240	COG1902	pentaerythritol trinitrate reductase activity
EB_RS16245	COG0779	Required for maturation of 30S ribosomal subunits
EB_RS16250	COG2251	uridine kinase activity
EB_RS16250	COG0195	Participates in both transcription termination and antitermination
EB_RS16255	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EB_RS16260	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EB_RS16265	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EB_RS16270	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EB_RS16275	COG1185	polyribonucleotide nucleotidyltransferase activity
EB_RS16280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EB_RS16305	COG3657	addiction module killer protein
EB_RS16310	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EB_RS16320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EB_RS16355	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EB_RS16360	COG3657	addiction module killer protein
EB_RS16365	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EB_RS16400	COG0438	transferase activity, transferring glycosyl groups
EB_RS16445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EB_RS16450	COG1086	Polysaccharide biosynthesis protein
EB_RS16455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EB_RS16480	COG2916	Histone family protein nucleoid-structuring protein H-NS
EB_RS16500	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EB_RS16515	COG2916	Histone family protein nucleoid-structuring protein H-NS
EB_RS16605	COG1484	DNA-dependent DNA replication
EB_RS16635	COG2916	Histone family protein nucleoid-structuring protein H-NS
EB_RS16685	COG2916	Histone family protein nucleoid-structuring protein H-NS
EB_RS16710	COG1487	ribonuclease activity
EB_RS16720	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EB_RS16725	COG0024	Methionine aminopeptidase
EB_RS16730	COG0052	Belongs to the universal ribosomal protein uS2 family
EB_RS16735	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EB_RS16740	COG0528	UMP kinase activity
EB_RS16745	COG0233	cytoplasmic translational termination
EB_RS16750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EB_RS16755	COG0575	Belongs to the CDS family
EB_RS16760	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EB_RS16780	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EB_RS16785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EB_RS16790	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EB_RS16795	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EB_RS16800	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EB_RS16810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EB_RS16815	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EB_RS16820	COG2226	methyltransferase
EB_RS16825	COG2267	carboxylic ester hydrolase activity
EB_RS16830	COG0156	8-amino-7-oxononanoate synthase activity
EB_RS16840	COG3022	response to hydroperoxide
EB_RS16845	COG2866	Carboxypeptidase
EB_RS16880	COG0560	Phosphoserine phosphatase
EB_RS16885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EB_RS16890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EB_RS16895	COG1773	rubredoxin
EB_RS16905	COG3360	Dodecin
EB_RS16915	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EB_RS16920	COG2900	Belongs to the SlyX family
EB_RS16925	COG2205	protein histidine kinase activity
EB_RS16925	COG0784	Response regulator, receiver
EB_RS16950	COG3474	cytochrome
EB_RS16975	COG1028	Short-chain dehydrogenase reductase Sdr
EB_RS16980	COG2133	pyrroloquinoline quinone binding
EB_RS17015	COG1607	acyl-coa hydrolase
EB_RS17020	COG4628	conserved protein (DUF2132)
EB_RS17035	COG4772	TonB-dependent receptor
EB_RS17040	COG3263	regulation of cellular component size
EB_RS17055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EB_RS17060	COG0488	(ABC) transporter
EB_RS17085	COG0583	DNA-binding transcription factor activity
EB_RS17095	COG1215	transferase activity, transferring glycosyl groups
EB_RS17110	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EB_RS17110	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EB_RS17115	COG0509	glycine decarboxylation via glycine cleavage system
EB_RS17120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EB_RS17125	COG0613	PHP domain protein
EB_RS17130	COG0009	L-threonylcarbamoyladenylate synthase
EB_RS17135	COG1994	Peptidase M50
EB_RS17140	COG0180	Tryptophanyl-tRNA synthetase
EB_RS17145	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EB_RS17150	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EB_RS17160	COG0739	heme binding
EB_RS17160	COG1196	nuclear chromosome segregation
EB_RS17160	COG0741	lytic transglycosylase activity
EB_RS17175	COG0047	phosphoribosylformylglycinamidine synthase activity
EB_RS17175	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EB_RS17210	COG0824	Thioesterase
EB_RS17220	COG0504	CTP synthase activity
EB_RS17225	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EB_RS17230	COG0148	phosphopyruvate hydratase activity
EB_RS17235	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EB_RS17240	COG0791	NLP P60 protein
EB_RS17260	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EB_RS17270	COG0306	phosphate transporter
EB_RS17280	COG0302	gtp cyclohydrolase
EB_RS17295	COG4681	YaeQ
EB_RS17305	COG1253	flavin adenine dinucleotide binding
EB_RS17310	COG1012	belongs to the aldehyde dehydrogenase family
EB_RS17330	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EB_RS17345	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EB_RS17350	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EB_RS17355	COG4208	sulfate ABC transporter
EB_RS17360	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EB_RS17380	COG3300	MHYT domain
EB_RS17380	COG5001	Diguanylate cyclase
EB_RS17395	COG0484	heat shock protein binding
EB_RS17415	COG1131	(ABC) transporter
EB_RS17420	COG0842	Transport permease protein
EB_RS17425	COG0058	SHG alpha-glucan phosphorylase activity
EB_RS17430	COG0642	Histidine kinase
EB_RS17445	COG4221	oxidoreductase activity
EB_RS17455	COG0318	PFAM AMP-dependent synthetase and ligase
EB_RS17470	COG1309	transcriptional regulator
EB_RS17475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EB_RS17485	COG1136	(ABC) transporter
EB_RS17525	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EB_RS17550	COG4263	nitrous-oxide reductase activity
EB_RS17560	COG2197	response regulator
EB_RS17565	COG3850	Histidine kinase
EB_RS17570	COG2181	nitrate reductase activity
EB_RS17575	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EB_RS17580	COG1140	nitrate reductase beta subunit
EB_RS17585	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EB_RS17615	COG2081	HI0933 family
EB_RS17645	COG1671	Belongs to the UPF0178 family
EB_RS17655	COG0534	Mate efflux family protein
EB_RS17745	COG1484	DNA-dependent DNA replication
EB_RS17770	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EB_RS17790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EB_RS17795	COG1881	PFAM PEBP family protein
EB_RS17820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EB_RS17825	COG3115	cell septum assembly
EB_RS17830	COG1196	nuclear chromosome segregation
EB_RS17840	COG2171	N-acyltransferase activity
EB_RS17850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EB_RS17860	COG0784	Response regulator, receiver
EB_RS17865	COG0386	Belongs to the glutathione peroxidase family
EB_RS17875	COG0633	Ferredoxin
EB_RS17880	COG0443	Heat shock 70 kDa protein
EB_RS17885	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EB_RS17890	COG0316	Belongs to the HesB IscA family
EB_RS17895	COG0822	iron-sulfur transferase activity
EB_RS17900	COG1104	cysteine desulfurase activity
EB_RS17905	COG1104	cysteine desulfurase activity
EB_RS17915	COG1045	serine acetyltransferase
EB_RS17925	COG0483	inositol monophosphate 1-phosphatase activity
EB_RS17960	COG0107	imidazoleglycerol-phosphate synthase activity
EB_RS17975	COG0243	molybdopterin cofactor binding
EB_RS17995	COG3852	Histidine kinase
EB_RS18000	COG2204	response regulator
EB_RS18025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EB_RS18035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EB_RS18040	COG0328	RNA-DNA hybrid ribonuclease activity
EB_RS18045	COG2226	methyltransferase
EB_RS18050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EB_RS18055	COG1388	LysM domain
EB_RS18055	COG0741	lytic transglycosylase activity
EB_RS18060	COG4172	Belongs to the ABC transporter superfamily
EB_RS18070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EB_RS18075	COG2207	Transcriptional regulator
EB_RS18095	COG2205	protein histidine kinase activity
EB_RS18105	COG0583	DNA-binding transcription factor activity
EB_RS18110	COG0477	Major facilitator Superfamily
EB_RS18115	COG1573	uracil-dna glycosylase
EB_RS18120	COG0456	acetyltransferase
EB_RS18125	COG1214	PFAM Peptidase M22, glycoprotease
EB_RS18145	COG2917	probably involved in intracellular septation
EB_RS18150	COG2350	Protein conserved in bacteria
EB_RS18160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EB_RS18165	COG1960	acyl-CoA dehydrogenase activity
EB_RS18185	COG1309	transcriptional regulator
EB_RS18190	COG0084	hydrolase, TatD family'
EB_RS18200	COG0318	PFAM AMP-dependent synthetase and ligase
EB_RS18215	COG1127	ABC transporter
EB_RS18220	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EB_RS18225	COG0248	Ppx GppA phosphatase
EB_RS18230	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EB_RS18235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EB_RS18245	COG3228	Belongs to the MtfA family
EB_RS18265	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EB_RS18270	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EB_RS18275	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EB_RS18285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EB_RS18295	COG1355	regulation of microtubule-based process
EB_RS18300	COG3885	ferrous iron binding
EB_RS18300	COG2078	PFAM AMMECR1 domain protein
EB_RS18315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EB_RS18335	COG3001	Fructosamine kinase
EB_RS18355	COG4680	protein conserved in bacteria
EB_RS18395	COG0210	DNA helicase
EB_RS18415	COG1401	restriction endodeoxyribonuclease activity
EB_RS18540	COG0582	viral genome integration into host DNA
EB_RS18545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EB_RS18545	COG0519	Catalyzes the synthesis of GMP from XMP
EB_RS18560	COG2914	Belongs to the UPF0125 (RnfH) family
EB_RS18565	COG2867	negative regulation of translational initiation
EB_RS18570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EB_RS18575	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EB_RS18590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EB_RS18595	COG0601	transmembrane transport
EB_RS18610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EB_RS18615	COG0542	response to heat
EB_RS18625	COG0314	molybdopterin synthase activity
EB_RS18630	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EB_RS18635	COG0303	'Molybdopterin
EB_RS18640	COG1763	Mo-molybdopterin cofactor biosynthetic process
EB_RS18650	COG1199	ATP-dependent helicase activity
EB_RS18660	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EB_RS18665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EB_RS18670	COG0508	dehydrogenase complex catalyzes the overall conversion of
EB_RS18675	COG0567	Dehydrogenase, E1 component
EB_RS18680	COG0372	Belongs to the citrate synthase family
EB_RS18690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EB_RS18695	COG1053	succinate dehydrogenase
EB_RS18710	COG2188	Transcriptional regulator
EB_RS18715	COG0039	L-malate dehydrogenase activity
EB_RS18725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EB_RS18740	COG1132	(ABC) transporter
EB_RS18750	COG0668	transmembrane transport
EB_RS18800	COG0277	FAD linked oxidase domain protein
EB_RS18810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EB_RS18815	COG1129	ABC transporter
EB_RS18815	COG0842	Transport permease protein
EB_RS18820	COG0842	Transport permease protein
EB_RS18840	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EB_RS18845	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EB_RS18860	COG0129	dihydroxy-acid dehydratase activity
EB_RS18880	COG2124	cytochrome p450
EB_RS18890	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EB_RS18915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EB_RS18920	COG3077	Addiction module antitoxin, RelB DinJ family
EB_RS18935	COG0484	heat shock protein binding
EB_RS18940	COG0489	protein tyrosine kinase activity
EB_RS18950	COG4464	protein tyrosine phosphatase activity
EB_RS18970	COG1136	(ABC) transporter
EB_RS18975	COG1562	ergosterol biosynthetic process
EB_RS18980	COG1562	ergosterol biosynthetic process
EB_RS18985	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
EB_RS18990	COG4181	ATPase activity
EB_RS19005	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EB_RS19015	COG3852	Histidine kinase
EB_RS19020	COG0045	succinate-CoA ligase (ADP-forming) activity
EB_RS19020	COG1042	CoA-binding domain protein
EB_RS19020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EB_RS19030	COG2183	response to ionizing radiation
EB_RS19040	COG0850	regulation of cytokinetic process
EB_RS19050	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EB_RS19055	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EB_RS19060	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EB_RS19060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EB_RS19070	COG2197	response regulator
EB_RS19080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EB_RS19105	COG1090	epimerase
EB_RS19115	COG1546	Belongs to the CinA family
EB_RS19115	COG1058	Belongs to the CinA family
EB_RS19120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EB_RS19135	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EB_RS19140	COG1672	PFAM Archaeal ATPase
EB_RS19140	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EB_RS19150	COG1285	pathogenesis
EB_RS19160	COG5265	(ABC) transporter
EB_RS19200	COG2204	response regulator
EB_RS19210	COG0297	glycogen (starch) synthase activity
EB_RS19220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EB_RS19225	COG0859	PFAM glycosyl transferase family 9
EB_RS19235	COG0297	glycogen (starch) synthase activity
EB_RS19240	COG1640	4-alpha-glucanotransferase
EB_RS19245	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EB_RS19250	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EB_RS19265	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EB_RS19265	COG3264	Mechanosensitive ion channel
EB_RS19275	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EB_RS19285	COG0438	transferase activity, transferring glycosyl groups
EB_RS19295	COG0671	phosphoesterase, PA-phosphatase related
EB_RS19300	COG0438	transferase activity, transferring glycosyl groups
EB_RS19305	COG2193	ferroxidase activity
EB_RS19310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EB_RS19335	COG1252	NADH dehydrogenase
EB_RS19350	COG0628	permease
EB_RS19355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EB_RS19360	COG2823	Periplasmic or secreted lipoprotein
EB_RS19365	COG2823	Periplasmic or secreted lipoprotein
EB_RS19380	COG0517	IMP dehydrogenase activity
EB_RS19395	COG0189	ligase activity
EB_RS19420	COG1028	Short-chain dehydrogenase reductase Sdr
EB_RS19435	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EB_RS19440	COG0366	Alpha amylase catalytic
EB_RS19445	COG0366	Alpha amylase catalytic
EB_RS19450	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EB_RS19460	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
EB_RS19490	COG0579	oxidoreductase
EB_RS19500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EB_RS19510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EB_RS19515	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EB_RS19520	COG1674	ftsk spoiiie
EB_RS19530	COG0492	ferredoxin-NADP+ reductase activity
EB_RS19535	COG2840	Smr protein MutS2
EB_RS19540	COG0347	Belongs to the P(II) protein family
EB_RS19545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EB_RS19545	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EB_RS19555	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EB_RS19600	COG2813	Specifically methylates the guanine in position
EB_RS19605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EB_RS19620	COG1028	Short-chain dehydrogenase reductase Sdr
EB_RS19665	COG5499	transcription regulator containing HTH domain
EB_RS19680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EB_RS19690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EB_RS19700	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EB_RS19705	COG0628	permease
EB_RS19710	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EB_RS19720	COG0617	tRNA 3'-terminal CCA addition
EB_RS19730	COG1428	Deoxynucleoside kinase
EB_RS19735	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EB_RS19740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EB_RS19745	COG0516	GMP reductase activity
EB_RS19745	COG0517	IMP dehydrogenase activity
EB_RS19750	COG0308	aminopeptidase N
EB_RS19775	COG0028	Belongs to the TPP enzyme family
EB_RS19780	COG0440	acetolactate synthase activity
EB_RS19785	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EB_RS19790	COG0688	phosphatidylethanolamine metabolic process
EB_RS19795	COG1183	phosphatidylcholine synthase activity
EB_RS19820	COG1858	cytochrome C peroxidase
EB_RS19835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EB_RS19840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EB_RS19855	COG1295	ribonuclease BN
EB_RS19865	COG0228	four-way junction DNA binding
EB_RS19870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EB_RS19875	COG0336	Belongs to the RNA methyltransferase TrmD family
EB_RS19880	COG0335	large ribosomal subunit rRNA binding
EB_RS19890	COG0795	lipopolysaccharide-transporting ATPase activity
EB_RS19895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EB_RS19910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EB_RS19925	COG0525	valine-tRNA ligase activity
EB_RS19930	COG0425	Belongs to the sulfur carrier protein TusA family
EB_RS19935	COG4783	chaperone-mediated protein folding
EB_RS19940	COG0315	cyclic pyranopterin monophosphate synthase activity
EB_RS19945	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EB_RS19950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EB_RS19950	COG2169	Transcriptional regulator
EB_RS19955	COG1819	glycosyl
EB_RS20015	COG1487	ribonuclease activity
EB_RS20020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EB_RS20025	COG0604	alcohol dehydrogenase
EB_RS20030	COG0488	(ABC) transporter
EB_RS20135	COG0740	serine-type endopeptidase activity
EB_RS20150	COG3179	chitinase
EB_RS20315	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EB_RS20320	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EB_RS20605	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EB_RS21010	COG0582	viral genome integration into host DNA
EB_RS21020	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EB_RS21030	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EB_RS21305	COG0183	Belongs to the thiolase family
EB_RS21355	COG0439	Biotin carboxylase
EB_RS21895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EB_RS21950	COG4584	PFAM Integrase catalytic
EB_RS21960	COG4584	PFAM Integrase catalytic
EB_RS22350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EB_RS22440	COG4197	protein conserved in bacteria, prophage-related
EB_RS22600	COG5001	Diguanylate cyclase
EB_RS22615	COG4585	Histidine kinase
EB_RS22630	COG4251	negative regulation of phosphorylation
EB_RS22660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EB_RS22675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EB_RS22745	COG0318	PFAM AMP-dependent synthetase and ligase
EB_RS22780	COG3012	SEC-C Motif Domain Protein
EB_RS22800	COG2205	protein histidine kinase activity
EB_RS22920	COG4584	PFAM Integrase catalytic