locus-tag	class	description
ToN1_RS00025	COG4638	Rieske (2fe-2S)
ToN1_RS00030	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ToN1_RS00035	COG1022	Amp-dependent synthetase and ligase
ToN1_RS00050	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ToN1_RS00070	COG0252	asparaginase activity
ToN1_RS00075	COG1126	abc transporter atp-binding protein
ToN1_RS00080	COG0010	Belongs to the arginase family
ToN1_RS00085	COG0765	amino acid transport
ToN1_RS00090	COG0765	amino acid transport
ToN1_RS00095	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ToN1_RS00170	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ToN1_RS00220	COG1695	Transcriptional regulator
ToN1_RS00245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ToN1_RS00250	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ToN1_RS00265	COG0328	RNA-DNA hybrid ribonuclease activity
ToN1_RS00275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ToN1_RS00280	COG5001	Diguanylate cyclase
ToN1_RS00280	COG4251	negative regulation of phosphorylation
ToN1_RS00280	COG2203	Gaf domain
ToN1_RS00280	COG3706	GGDEF domain
ToN1_RS00285	COG1388	LysM domain
ToN1_RS00285	COG0741	lytic transglycosylase activity
ToN1_RS00300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ToN1_RS00305	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ToN1_RS00320	COG0534	Mate efflux family protein
ToN1_RS00325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ToN1_RS00330	COG5002	protein histidine kinase activity
ToN1_RS00330	COG2205	protein histidine kinase activity
ToN1_RS00330	COG0784	Response regulator, receiver
ToN1_RS00335	COG0587	DNA-directed DNA polymerase activity
ToN1_RS00360	COG2154	pterin-4-alpha-carbinolamine dehydratase
ToN1_RS00395	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ToN1_RS00400	COG1140	nitrate reductase beta subunit
ToN1_RS00405	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ToN1_RS00410	COG2181	nitrate reductase activity
ToN1_RS00415	COG3850	Histidine kinase
ToN1_RS00420	COG2197	response regulator
ToN1_RS00430	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ToN1_RS00440	COG4263	nitrous-oxide reductase activity
ToN1_RS00500	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ToN1_RS00505	COG0560	Phosphoserine phosphatase
ToN1_RS00510	COG2866	Carboxypeptidase
ToN1_RS00515	COG3022	response to hydroperoxide
ToN1_RS00525	COG0156	8-amino-7-oxononanoate synthase activity
ToN1_RS00530	COG2267	carboxylic ester hydrolase activity
ToN1_RS00535	COG2226	methyltransferase
ToN1_RS00540	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ToN1_RS00545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ToN1_RS00555	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ToN1_RS00560	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ToN1_RS00565	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ToN1_RS00570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ToN1_RS00575	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ToN1_RS00595	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ToN1_RS00600	COG0575	Belongs to the CDS family
ToN1_RS00605	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ToN1_RS00610	COG0233	cytoplasmic translational termination
ToN1_RS00615	COG0528	UMP kinase activity
ToN1_RS00620	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ToN1_RS00625	COG0052	Belongs to the universal ribosomal protein uS2 family
ToN1_RS00635	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ToN1_RS00640	COG2862	Uncharacterized protein family, UPF0114
ToN1_RS00650	COG2151	metal-sulfur cluster biosynthetic enzyme
ToN1_RS00735	COG1881	PFAM PEBP family protein
ToN1_RS00740	COG1024	Enoyl-CoA hydratase
ToN1_RS00765	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS00770	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS00775	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS00775	COG3321	synthase
ToN1_RS00775	COG0604	alcohol dehydrogenase
ToN1_RS00800	COG4447	cellulose binding
ToN1_RS00850	COG1132	(ABC) transporter
ToN1_RS00865	COG0641	radical SAM
ToN1_RS00875	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_RS00880	COG0826	peptidase U32
ToN1_RS00925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_RS00955	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS00960	COG0183	Belongs to the thiolase family
ToN1_RS00975	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS00980	COG0583	DNA-binding transcription factor activity
ToN1_RS00985	COG0583	DNA-binding transcription factor activity
ToN1_RS01000	COG1819	glycosyl
ToN1_RS01030	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_RS01035	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
ToN1_RS01040	COG0028	Belongs to the TPP enzyme family
ToN1_RS01045	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS01050	COG1414	Transcriptional regulator
ToN1_RS01065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ToN1_RS01075	COG1116	anion transmembrane transporter activity
ToN1_RS01090	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ToN1_RS01095	COG2304	oxidoreductase activity
ToN1_RS01120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ToN1_RS01155	COG0183	Belongs to the thiolase family
ToN1_RS01170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ToN1_RS01175	COG2151	metal-sulfur cluster biosynthetic enzyme
ToN1_RS01180	COG3396	Phenylacetate-CoA oxygenase
ToN1_RS01185	COG3460	Phenylacetate-CoA oxygenase
ToN1_RS01190	COG3396	Phenylacetate-CoA oxygenase
ToN1_RS01195	COG4654	Cytochrome c, class I
ToN1_RS01210	COG2197	response regulator
ToN1_RS01215	COG3851	Histidine kinase
ToN1_RS01225	COG2204	response regulator
ToN1_RS01240	COG1294	oxidase, subunit
ToN1_RS01260	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS01265	COG0183	Belongs to the thiolase family
ToN1_RS01270	COG1024	Enoyl-CoA hydratase
ToN1_RS01270	COG1250	3-hydroxyacyl-CoA dehydrogenase
ToN1_RS01275	COG2207	Transcriptional regulator
ToN1_RS01285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ToN1_RS01290	COG0488	(ABC) transporter
ToN1_RS01305	COG1335	isochorismatase
ToN1_RS01315	COG0583	DNA-binding transcription factor activity
ToN1_RS01345	COG4451	ribulose bisphosphate carboxylase, small
ToN1_RS01355	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ToN1_RS01360	COG3954	Phosphoribulokinase
ToN1_RS01365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ToN1_RS01370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ToN1_RS01375	COG0126	phosphoglycerate kinase activity
ToN1_RS01380	COG0191	fructose-bisphosphate aldolase activity
ToN1_RS01405	COG1595	DNA-templated transcription, initiation
ToN1_RS01410	COG0701	Predicted permease
ToN1_RS01420	COG1230	cation diffusion facilitator family transporter
ToN1_RS01520	COG2855	membrane
ToN1_RS01560	COG2197	response regulator
ToN1_RS01570	COG1924	4 iron, 4 sulfur cluster binding
ToN1_RS01585	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ToN1_RS01600	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS01605	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS01620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ToN1_RS01620	COG0300	oxidoreductase activity
ToN1_RS01620	COG3321	synthase
ToN1_RS01620	COG4221	oxidoreductase activity
ToN1_RS01625	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_RS01650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ToN1_RS01690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ToN1_RS01705	COG1013	pyruvate-flavodoxin oxidoreductase activity
ToN1_RS01710	COG0674	pyruvate-flavodoxin oxidoreductase activity
ToN1_RS01710	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ToN1_RS01725	COG0730	response to heat
ToN1_RS01740	COG0183	Belongs to the thiolase family
ToN1_RS01750	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ToN1_RS01755	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ToN1_RS01760	COG2855	membrane
ToN1_RS01770	COG4447	cellulose binding
ToN1_RS01785	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_RS01800	COG2146	nitrite reductase [NAD(P)H] activity
ToN1_RS01815	COG2175	clavaminate synthase activity
ToN1_RS01820	COG3246	L-lysine catabolic process to acetate
ToN1_RS01850	COG1953	Uracil, thiamine, allantoin
ToN1_RS01860	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_RS01875	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ToN1_RS01880	COG3657	addiction module killer protein
ToN1_RS01895	COG2409	Drug exporters of the RND superfamily
ToN1_RS01935	COG0583	DNA-binding transcription factor activity
ToN1_RS01940	COG2828	Protein conserved in bacteria
ToN1_RS01960	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
ToN1_RS01980	COG0583	DNA-binding transcription factor activity
ToN1_RS01985	COG1053	succinate dehydrogenase
ToN1_RS02000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ToN1_RS02005	COG2828	Protein conserved in bacteria
ToN1_RS02030	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ToN1_RS02175	COG0657	acetylesterase activity
ToN1_RS02235	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ToN1_RS02240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_RS02250	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS02260	COG0183	Belongs to the thiolase family
ToN1_RS02265	COG1946	Acyl-CoA thioesterase
ToN1_RS02275	COG1024	Enoyl-CoA hydratase
ToN1_RS02280	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS02285	COG1024	Enoyl-CoA hydratase
ToN1_RS02290	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS02295	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS02310	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS02320	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS02340	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS02345	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS02350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_RS02355	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS02360	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS02385	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_RS02395	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS02405	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS02410	COG2814	Major facilitator Superfamily
ToN1_RS02425	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS02430	COG2079	MmgE PrpD family protein
ToN1_RS02435	COG0183	Belongs to the thiolase family
ToN1_RS02445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_RS02460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ToN1_RS02475	COG1013	pyruvate-flavodoxin oxidoreductase activity
ToN1_RS02480	COG0674	pyruvate-flavodoxin oxidoreductase activity
ToN1_RS02480	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ToN1_RS02500	COG4974	Belongs to the 'phage' integrase family
ToN1_RS02515	COG1024	Enoyl-CoA hydratase
ToN1_RS02540	COG2814	Major facilitator Superfamily
ToN1_RS02555	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS02565	COG2030	dehydratase
ToN1_RS02575	COG1024	Enoyl-CoA hydratase
ToN1_RS02585	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ToN1_RS02600	COG1024	Enoyl-CoA hydratase
ToN1_RS02605	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS02610	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS02615	COG1024	Enoyl-CoA hydratase
ToN1_RS02620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_RS02625	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS02630	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
ToN1_RS02645	COG2301	Belongs to the HpcH HpaI aldolase family
ToN1_RS02660	COG2030	dehydratase
ToN1_RS02665	COG0183	Belongs to the thiolase family
ToN1_RS02675	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS02680	COG1024	Enoyl-CoA hydratase
ToN1_RS02685	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_RS02690	COG1024	Enoyl-CoA hydratase
ToN1_RS02700	COG1024	Enoyl-CoA hydratase
ToN1_RS02735	COG4447	cellulose binding
ToN1_RS02750	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS02755	COG1024	Enoyl-CoA hydratase
ToN1_RS02760	COG2365	Tyrosine phosphatase family
ToN1_RS02765	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS02830	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ToN1_RS02850	COG2814	Major facilitator Superfamily
ToN1_RS02865	COG1063	alcohol dehydrogenase
ToN1_RS02870	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS02875	COG1024	Enoyl-CoA hydratase
ToN1_RS02915	COG1250	3-hydroxyacyl-CoA dehydrogenase
ToN1_RS02920	COG0179	Fumarylacetoacetate (FAA) hydrolase
ToN1_RS02955	COG2223	nitrite transmembrane transporter activity
ToN1_RS02970	COG0179	Fumarylacetoacetate (FAA) hydrolase
ToN1_RS02975	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS03045	COG2086	electron transfer activity
ToN1_RS03055	COG0583	DNA-binding transcription factor activity
ToN1_RS03060	COG2204	response regulator
ToN1_RS03065	COG0571	ribonuclease III activity
ToN1_RS03085	COG0302	gtp cyclohydrolase
ToN1_RS03095	COG1024	Enoyl-CoA hydratase
ToN1_RS03105	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS03115	COG2124	cytochrome p450
ToN1_RS03120	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS03140	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS03145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_RS03175	COG1233	COG1233 Phytoene dehydrogenase and related
ToN1_RS03200	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ToN1_RS03220	COG0427	acetyl-CoA hydrolase
ToN1_RS03225	COG0183	Belongs to the thiolase family
ToN1_RS03245	COG2365	Tyrosine phosphatase family
ToN1_RS03250	COG0183	Belongs to the thiolase family
ToN1_RS03315	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS03320	COG1902	pentaerythritol trinitrate reductase activity
ToN1_RS03325	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS03340	COG2030	dehydratase
ToN1_RS03345	COG1024	Enoyl-CoA hydratase
ToN1_RS03345	COG1250	3-hydroxyacyl-CoA dehydrogenase
ToN1_RS03350	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ToN1_RS03355	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS03370	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS03375	COG0596	Alpha beta hydrolase
ToN1_RS03385	COG0714	Associated with various cellular activities
ToN1_RS03410	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ToN1_RS03415	COG1140	nitrate reductase beta subunit
ToN1_RS03430	COG5001	Diguanylate cyclase
ToN1_RS03470	COG1845	cytochrome c oxidase, subunit III
ToN1_RS03515	COG0574	Belongs to the PEP-utilizing enzyme family
ToN1_RS03515	COG3848	Pyruvate phosphate dikinase
ToN1_RS03540	COG1024	Enoyl-CoA hydratase
ToN1_RS03545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ToN1_RS03590	COG4221	oxidoreductase activity
ToN1_RS03640	COG1192	Involved in chromosome partitioning
ToN1_RS03755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ToN1_RS03790	COG0484	heat shock protein binding
ToN1_RS03795	COG2003	Belongs to the UPF0758 family
ToN1_RS03840	COG5002	protein histidine kinase activity
ToN1_RS03845	COG1674	ftsk spoiiie
ToN1_RS03905	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ToN1_RS03935	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ToN1_RS03940	COG1185	polyribonucleotide nucleotidyltransferase activity
ToN1_RS03945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ToN1_RS03950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ToN1_RS03955	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ToN1_RS03960	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ToN1_RS03965	COG2251	uridine kinase activity
ToN1_RS03965	COG0195	Participates in both transcription termination and antitermination
ToN1_RS03970	COG0779	Required for maturation of 30S ribosomal subunits
ToN1_RS03980	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ToN1_RS03985	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ToN1_RS03990	COG0180	Tryptophanyl-tRNA synthetase
ToN1_RS03995	COG1994	Peptidase M50
ToN1_RS04000	COG0009	L-threonylcarbamoyladenylate synthase
ToN1_RS04005	COG0613	PHP domain protein
ToN1_RS04010	COG0509	glycine decarboxylation via glycine cleavage system
ToN1_RS04015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ToN1_RS04015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ToN1_RS04030	COG1215	transferase activity, transferring glycosyl groups
ToN1_RS04035	COG0583	DNA-binding transcription factor activity
ToN1_RS04050	COG0508	dehydrogenase complex catalyzes the overall conversion of
ToN1_RS04060	COG0488	(ABC) transporter
ToN1_RS04085	COG0577	efflux transmembrane transporter activity
ToN1_RS04090	COG1136	(ABC) transporter
ToN1_RS04100	COG3447	MASE1 domain protein
ToN1_RS04100	COG5002	protein histidine kinase activity
ToN1_RS04100	COG5001	Diguanylate cyclase
ToN1_RS04105	COG1562	ergosterol biosynthetic process
ToN1_RS04115	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ToN1_RS04120	COG4181	ATPase activity
ToN1_RS04135	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
ToN1_RS04145	COG4191	Histidine kinase
ToN1_RS04155	COG1132	(ABC) transporter
ToN1_RS04175	COG1042	CoA-binding domain protein
ToN1_RS04175	COG0045	succinate-CoA ligase (ADP-forming) activity
ToN1_RS04175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ToN1_RS04185	COG2183	response to ionizing radiation
ToN1_RS04190	COG1393	Belongs to the ArsC family
ToN1_RS04200	COG0850	regulation of cytokinetic process
ToN1_RS04210	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ToN1_RS04220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ToN1_RS04225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ToN1_RS04225	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ToN1_RS04230	COG4585	Histidine kinase
ToN1_RS04235	COG2197	response regulator
ToN1_RS04265	COG0574	Belongs to the PEP-utilizing enzyme family
ToN1_RS04265	COG3848	Pyruvate phosphate dikinase
ToN1_RS04275	COG0517	IMP dehydrogenase activity
ToN1_RS04285	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ToN1_RS04300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ToN1_RS04320	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ToN1_RS04340	COG2816	NAD+ diphosphatase activity
ToN1_RS04345	COG0450	alkyl hydroperoxide reductase
ToN1_RS04350	COG3634	alkyl hydroperoxide reductase activity
ToN1_RS04375	COG2202	Pas domain
ToN1_RS04375	COG2205	protein histidine kinase activity
ToN1_RS04415	COG2204	response regulator
ToN1_RS04425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ToN1_RS04430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ToN1_RS04440	COG1538	Outer membrane efflux protein
ToN1_RS04445	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ToN1_RS04460	COG0515	serine threonine protein kinase
ToN1_RS04465	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ToN1_RS04480	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS04490	COG0183	Belongs to the thiolase family
ToN1_RS04495	COG1024	Enoyl-CoA hydratase
ToN1_RS04500	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_RS04525	COG4191	Histidine kinase
ToN1_RS04540	COG2151	metal-sulfur cluster biosynthetic enzyme
ToN1_RS04550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ToN1_RS04555	COG0719	Fe-S assembly protein
ToN1_RS04560	COG0396	ATPase activity
ToN1_RS04565	COG0719	Fe-S assembly protein
ToN1_RS04570	COG1067	ATP-dependent peptidase activity
ToN1_RS04575	COG1335	isochorismatase
ToN1_RS04585	COG1881	PFAM PEBP family protein
ToN1_RS04605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ToN1_RS04610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ToN1_RS04620	COG1196	nuclear chromosome segregation
ToN1_RS04630	COG2171	N-acyltransferase activity
ToN1_RS04640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ToN1_RS04650	COG0784	Response regulator, receiver
ToN1_RS04660	COG0633	Ferredoxin
ToN1_RS04665	COG0443	Heat shock 70 kDa protein
ToN1_RS04670	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ToN1_RS04680	COG0822	iron-sulfur transferase activity
ToN1_RS04685	COG1104	cysteine desulfurase activity
ToN1_RS04690	COG1104	cysteine desulfurase activity
ToN1_RS04700	COG1045	serine acetyltransferase
ToN1_RS04710	COG0483	inositol monophosphate 1-phosphatase activity
ToN1_RS04715	COG0513	Belongs to the DEAD box helicase family
ToN1_RS04755	COG0322	excinuclease ABC activity
ToN1_RS04760	COG1472	Belongs to the glycosyl hydrolase 3 family
ToN1_RS04765	COG0736	holo-[acyl-carrier-protein] synthase activity
ToN1_RS04770	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ToN1_RS04775	COG1381	Involved in DNA repair and RecF pathway recombination
ToN1_RS04780	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ToN1_RS04785	COG0571	ribonuclease III activity
ToN1_RS04795	COG0681	Belongs to the peptidase S26 family
ToN1_RS04800	COG0481	GTPase activity
ToN1_RS04810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ToN1_RS04835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ToN1_RS04850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ToN1_RS04865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ToN1_RS04870	COG0416	fatty acid biosynthetic process
ToN1_RS04875	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ToN1_RS04880	COG1399	metal-binding, possibly nucleic acid-binding protein
ToN1_RS04885	COG0424	maF-like protein
ToN1_RS04890	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ToN1_RS04895	COG0546	phosphoglycolate phosphatase activity
ToN1_RS04905	COG1530	ribonuclease E activity
ToN1_RS04910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ToN1_RS04915	COG0556	nucleotide-excision repair
ToN1_RS04935	COG1067	ATP-dependent peptidase activity
ToN1_RS04945	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ToN1_RS04965	COG1473	amidohydrolase
ToN1_RS04975	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ToN1_RS04990	COG0717	Belongs to the dCTP deaminase family
ToN1_RS05005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ToN1_RS05005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ToN1_RS05010	COG0659	secondary active sulfate transmembrane transporter activity
ToN1_RS05015	COG1254	Belongs to the acylphosphatase family
ToN1_RS05035	COG0840	transmembrane signaling receptor activity
ToN1_RS05040	COG0450	alkyl hydroperoxide reductase
ToN1_RS05065	COG0281	malic enzyme
ToN1_RS05065	COG0280	phosphate acetyltransferase
ToN1_RS05070	COG1192	Involved in chromosome partitioning
ToN1_RS05075	COG0210	DNA helicase
ToN1_RS05085	COG0495	leucyl-tRNA aminoacylation
ToN1_RS05095	COG1466	dna polymerase III delta subunit
ToN1_RS05100	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ToN1_RS05110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ToN1_RS05115	COG4974	Belongs to the 'phage' integrase family
ToN1_RS05120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ToN1_RS05135	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ToN1_RS05140	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ToN1_RS05145	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ToN1_RS05250	COG1305	Transglutaminase-like
ToN1_RS05275	COG2308	Evidence 4 Homologs of previously reported genes of
ToN1_RS05310	COG0730	response to heat
ToN1_RS05315	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ToN1_RS05330	COG4206	TonB-dependent receptor
ToN1_RS05365	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ToN1_RS05375	COG0538	isocitrate dehydrogenase activity
ToN1_RS05385	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ToN1_RS05405	COG0446	pyridine nucleotide-disulphide oxidoreductase
ToN1_RS05415	COG0756	dUTP diphosphatase activity
ToN1_RS05420	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ToN1_RS05425	COG2003	Belongs to the UPF0758 family
ToN1_RS05430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ToN1_RS05435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ToN1_RS05440	COG1278	Cold shock
ToN1_RS05445	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ToN1_RS05450	COG0542	response to heat
ToN1_RS05455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ToN1_RS05480	COG0583	DNA-binding transcription factor activity
ToN1_RS05495	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ToN1_RS05500	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ToN1_RS05520	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ToN1_RS05530	COG0802	atpase or kinase
ToN1_RS05535	COG0860	N-Acetylmuramoyl-L-alanine amidase
ToN1_RS05540	COG0196	riboflavin kinase activity
ToN1_RS05545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ToN1_RS05550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ToN1_RS05555	COG1047	Peptidyl-prolyl cis-trans
ToN1_RS05560	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ToN1_RS05580	COG1722	exodeoxyribonuclease VII activity
ToN1_RS05585	COG0142	geranyltranstransferase activity
ToN1_RS05590	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ToN1_RS05595	COG1469	GTP cyclohydrolase I activity
ToN1_RS05600	COG2030	dehydratase
ToN1_RS05610	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ToN1_RS05620	COG0142	geranyltranstransferase activity
ToN1_RS05625	COG0584	glycerophosphoryl diester phosphodiesterase
ToN1_RS05640	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ToN1_RS05645	COG0513	Belongs to the DEAD box helicase family
ToN1_RS05665	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ToN1_RS05675	COG0598	Magnesium transport protein CorA
ToN1_RS05680	COG0631	protein serine/threonine phosphatase activity
ToN1_RS05685	COG0247	lactate metabolic process
ToN1_RS05690	COG0277	FAD linked oxidase domain protein
ToN1_RS05700	COG0277	FAD linked oxidase domain protein
ToN1_RS05710	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ToN1_RS05715	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ToN1_RS05720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ToN1_RS05725	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ToN1_RS05775	COG1459	type II secretion system
ToN1_RS05780	COG0741	lytic transglycosylase activity
ToN1_RS05785	COG1819	glycosyl
ToN1_RS05810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ToN1_RS05820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ToN1_RS05825	COG0745	RESPONSE REGULATOR receiver
ToN1_RS05830	COG0604	alcohol dehydrogenase
ToN1_RS05840	COG1704	LemA family
ToN1_RS05850	COG0488	(ABC) transporter
ToN1_RS05870	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ToN1_RS05885	COG2204	response regulator
ToN1_RS05890	COG5002	protein histidine kinase activity
ToN1_RS05895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ToN1_RS05905	COG0657	acetylesterase activity
ToN1_RS05960	COG2226	methyltransferase
ToN1_RS05975	COG2188	Transcriptional regulator
ToN1_RS05980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_RS05985	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS06005	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ToN1_RS06020	COG0154	amidase activity
ToN1_RS06065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ToN1_RS06070	COG1126	abc transporter atp-binding protein
ToN1_RS06075	COG0765	amino acid transport
ToN1_RS06080	COG0765	amino acid transport
ToN1_RS06090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ToN1_RS06095	COG1073	alpha beta
ToN1_RS06120	COG1953	Uracil, thiamine, allantoin
ToN1_RS06125	COG4266	Belongs to the allantoicase family
ToN1_RS06130	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
ToN1_RS06145	COG0402	S-adenosylhomocysteine deaminase activity
ToN1_RS06170	COG2252	PERMEase
ToN1_RS06190	COG2233	PERMEase
ToN1_RS06200	COG3195	allantoin biosynthetic process
ToN1_RS06200	COG3648	Uricase
ToN1_RS06210	COG1301	dicarboxylic acid transport
ToN1_RS06245	COG2319	Wd-40 repeat
ToN1_RS06245	COG4249	Peptidase C14 caspase catalytic subunit p20
ToN1_RS06280	COG3409	Peptidoglycan-binding domain 1 protein
ToN1_RS06280	COG3267	Type II secretory pathway component ExeA
ToN1_RS06290	COG0583	DNA-binding transcription factor activity
ToN1_RS06310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ToN1_RS06315	COG0456	acetyltransferase
ToN1_RS06335	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ToN1_RS06345	COG1742	UPF0060 membrane protein
ToN1_RS06380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ToN1_RS06395	COG2201	protein-glutamate methylesterase activity
ToN1_RS06430	COG3960	tartronate-semialdehyde synthase activity
ToN1_RS06435	COG3622	Belongs to the hyi family
ToN1_RS06440	COG2084	Dehydrogenase
ToN1_RS06460	COG0469	pyruvate kinase activity
ToN1_RS06465	COG2259	Doxx family
ToN1_RS06475	COG3260	NADH ubiquinone oxidoreductase 20
ToN1_RS06480	COG0649	NAD binding
ToN1_RS06485	COG0651	ATP synthesis coupled electron transport
ToN1_RS06495	COG0650	Formate hydrogenlyase subunit 4
ToN1_RS06500	COG0651	ATP synthesis coupled electron transport
ToN1_RS06520	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ToN1_RS06525	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ToN1_RS06530	COG0697	spore germination
ToN1_RS06535	COG0004	ammonium transporteR
ToN1_RS06555	COG0604	alcohol dehydrogenase
ToN1_RS06560	COG1309	transcriptional regulator
ToN1_RS06570	COG3135	benzoate transporter
ToN1_RS06575	COG1396	sequence-specific DNA binding
ToN1_RS06605	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ToN1_RS06605	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ToN1_RS06615	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ToN1_RS06630	COG2022	thiamine diphosphate biosynthetic process
ToN1_RS06640	COG2855	membrane
ToN1_RS06650	COG1113	amino acid transport
ToN1_RS06680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ToN1_RS06705	COG0730	response to heat
ToN1_RS06715	COG1414	Transcriptional regulator
ToN1_RS06720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ToN1_RS06730	COG2733	membrane
ToN1_RS06740	COG0861	Integral membrane protein TerC family
ToN1_RS06745	COG5002	protein histidine kinase activity
ToN1_RS06775	COG0642	Histidine kinase
ToN1_RS06780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ToN1_RS06810	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ToN1_RS06825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ToN1_RS06835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ToN1_RS06840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ToN1_RS06845	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ToN1_RS06850	COG0628	permease
ToN1_RS06855	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ToN1_RS06865	COG0617	tRNA 3'-terminal CCA addition
ToN1_RS06870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ToN1_RS06880	COG1428	Deoxynucleoside kinase
ToN1_RS06885	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ToN1_RS06890	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ToN1_RS06895	COG0516	GMP reductase activity
ToN1_RS06895	COG0517	IMP dehydrogenase activity
ToN1_RS06900	COG0308	aminopeptidase N
ToN1_RS06925	COG0028	Belongs to the TPP enzyme family
ToN1_RS06935	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ToN1_RS06940	COG0688	phosphatidylethanolamine metabolic process
ToN1_RS06945	COG1183	phosphatidylcholine synthase activity
ToN1_RS06950	COG1368	sulfuric ester hydrolase activity
ToN1_RS06985	COG1858	cytochrome C peroxidase
ToN1_RS07000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ToN1_RS07015	COG1295	ribonuclease BN
ToN1_RS07025	COG0228	four-way junction DNA binding
ToN1_RS07030	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ToN1_RS07035	COG0336	Belongs to the RNA methyltransferase TrmD family
ToN1_RS07040	COG0335	large ribosomal subunit rRNA binding
ToN1_RS07055	COG0527	aspartate kinase activity
ToN1_RS07070	COG0720	synthase
ToN1_RS07075	COG1196	nuclear chromosome segregation
ToN1_RS07075	COG3264	Mechanosensitive ion channel
ToN1_RS07080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ToN1_RS07085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ToN1_RS07085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ToN1_RS07095	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ToN1_RS07100	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ToN1_RS07115	COG0187	DNA topoisomerase II activity
ToN1_RS07130	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ToN1_RS07135	COG1984	allophanate hydrolase subunit 2
ToN1_RS07140	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ToN1_RS07145	COG2814	Major facilitator Superfamily
ToN1_RS07150	COG4336	lyase activity
ToN1_RS07155	COG0583	DNA-binding transcription factor activity
ToN1_RS07175	COG1360	Flagellar Motor Protein
ToN1_RS07180	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ToN1_RS07200	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ToN1_RS07225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ToN1_RS07240	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ToN1_RS07245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ToN1_RS07250	COG0123	including yeast histone deacetylase and acetoin utilization protein
ToN1_RS07255	COG0714	Associated with various cellular activities
ToN1_RS07270	COG2951	lytic endotransglycosylase activity
ToN1_RS07275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ToN1_RS07285	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ToN1_RS07290	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ToN1_RS07305	COG0776	regulation of translation
ToN1_RS07310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ToN1_RS07310	COG0072	phenylalanine-tRNA ligase activity
ToN1_RS07315	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ToN1_RS07320	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ToN1_RS07325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ToN1_RS07330	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ToN1_RS07335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ToN1_RS07350	COG0535	radical SAM domain protein
ToN1_RS07370	COG3391	amine dehydrogenase activity
ToN1_RS07380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ToN1_RS07380	COG1648	precorrin-2 dehydrogenase activity
ToN1_RS07410	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ToN1_RS07420	COG0776	regulation of translation
ToN1_RS07430	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ToN1_RS07435	COG0287	Prephenate dehydrogenase
ToN1_RS07445	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ToN1_RS07455	COG0402	S-adenosylhomocysteine deaminase activity
ToN1_RS07465	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ToN1_RS07515	COG0346	lactoylglutathione lyase activity
ToN1_RS07535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ToN1_RS07570	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ToN1_RS07590	COG0494	nUDIX hydrolase
ToN1_RS07600	COG0071	Belongs to the small heat shock protein (HSP20) family
ToN1_RS07605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ToN1_RS07615	COG0175	sulfate reduction
ToN1_RS07625	COG0471	metal ion transport
ToN1_RS07625	COG3273	potassium ion transport
ToN1_RS07630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ToN1_RS07650	COG5652	VanZ like family
ToN1_RS07675	COG0463	Glycosyl transferase, family 2
ToN1_RS07685	COG1215	transferase activity, transferring glycosyl groups
ToN1_RS07695	COG1215	transferase activity, transferring glycosyl groups
ToN1_RS07700	COG1216	Glycosyl transferase, family 2
ToN1_RS07705	COG3119	arylsulfatase activity
ToN1_RS07715	COG0297	glycogen (starch) synthase activity
ToN1_RS07725	COG1696	Membrane protein involved in D-alanine export
ToN1_RS07735	COG0367	asparagine synthase
ToN1_RS07745	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ToN1_RS07760	COG0438	transferase activity, transferring glycosyl groups
ToN1_RS07775	COG0367	asparagine synthase
ToN1_RS07780	COG0438	transferase activity, transferring glycosyl groups
ToN1_RS07800	COG3409	Peptidoglycan-binding domain 1 protein
ToN1_RS07800	COG3267	Type II secretory pathway component ExeA
ToN1_RS07810	COG0489	protein tyrosine kinase activity
ToN1_RS07830	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ToN1_RS07835	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ToN1_RS07845	COG1999	signal sequence binding
ToN1_RS07850	COG0109	protoheme IX farnesyltransferase activity
ToN1_RS07880	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
ToN1_RS07890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ToN1_RS07905	COG0300	oxidoreductase activity
ToN1_RS07925	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ToN1_RS07950	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ToN1_RS07955	COG2205	protein histidine kinase activity
ToN1_RS07970	COG0514	ATP-dependent DNA helicase (RecQ)
ToN1_RS07985	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ToN1_RS08000	COG0443	Heat shock 70 kDa protein
ToN1_RS08005	COG0733	neurotransmitter:sodium symporter activity
ToN1_RS08010	COG1522	sequence-specific DNA binding
ToN1_RS08020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ToN1_RS08025	COG2911	Protein conserved in bacteria
ToN1_RS08030	COG0134	indole-3-glycerol-phosphate synthase activity
ToN1_RS08035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ToN1_RS08050	COG0546	phosphoglycolate phosphatase activity
ToN1_RS08055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ToN1_RS08060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ToN1_RS08075	COG0631	protein serine/threonine phosphatase activity
ToN1_RS08080	COG2423	ornithine cyclodeaminase activity
ToN1_RS08085	COG0583	DNA-binding transcription factor activity
ToN1_RS08095	COG3842	ATPase activity
ToN1_RS08100	COG1176	ABC-type spermidine putrescine transport system, permease component I
ToN1_RS08110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ToN1_RS08140	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ToN1_RS08170	COG4566	intracellular signal transduction
ToN1_RS08175	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ToN1_RS08180	COG0037	tRNA processing
ToN1_RS08185	COG0825	malonyl-CoA metabolic process
ToN1_RS08190	COG1253	flavin adenine dinucleotide binding
ToN1_RS08195	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ToN1_RS08200	COG0670	Belongs to the BI1 family
ToN1_RS08215	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ToN1_RS08220	COG0343	queuine tRNA-ribosyltransferase activity
ToN1_RS08225	COG1862	Preprotein translocase
ToN1_RS08230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ToN1_RS08235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ToN1_RS08240	COG2095	MarC family integral membrane protein
ToN1_RS08255	COG2967	ApaG domain
ToN1_RS08260	COG0784	Response regulator, receiver
ToN1_RS08260	COG4191	Histidine kinase
ToN1_RS08265	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ToN1_RS08275	COG0653	protein targeting
ToN1_RS08290	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ToN1_RS08295	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ToN1_RS08310	COG1181	Belongs to the D-alanine--D-alanine ligase family
ToN1_RS08315	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ToN1_RS08320	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ToN1_RS08325	COG0772	Belongs to the SEDS family
ToN1_RS08330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ToN1_RS08335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ToN1_RS08340	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ToN1_RS08345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ToN1_RS08360	COG0275	rRNA processing
ToN1_RS08365	COG2001	Belongs to the MraZ family
ToN1_RS08380	COG0418	dihydroorotase activity
ToN1_RS08385	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ToN1_RS08390	COG0792	nuclease activity
ToN1_RS08395	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ToN1_RS08400	COG2823	Periplasmic or secreted lipoprotein
ToN1_RS08405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ToN1_RS08415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ToN1_RS08420	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ToN1_RS08425	COG0511	ligase activity, forming carbon-carbon bonds
ToN1_RS08430	COG0439	Biotin carboxylase
ToN1_RS08435	COG2264	protein methyltransferase activity
ToN1_RS08455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ToN1_RS08460	COG0537	adenosine 5'-monophosphoramidase activity
ToN1_RS08475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ToN1_RS08485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ToN1_RS08490	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ToN1_RS08510	COG1215	transferase activity, transferring glycosyl groups
ToN1_RS08525	COG1086	Polysaccharide biosynthesis protein
ToN1_RS08550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ToN1_RS08555	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ToN1_RS08555	COG0662	Cupin 2, conserved barrel domain protein
ToN1_RS08580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ToN1_RS08585	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ToN1_RS08600	COG1309	transcriptional regulator
ToN1_RS08625	COG2119	membrane
ToN1_RS08650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ToN1_RS08665	COG0351	phosphomethylpyrimidine kinase
ToN1_RS08670	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ToN1_RS08675	COG3258	Cytochrome c
ToN1_RS08690	COG1968	undecaprenyl-diphosphatase activity
ToN1_RS08695	COG3150	esterase
ToN1_RS08700	COG2226	methyltransferase
ToN1_RS08705	COG2962	Rard protein
ToN1_RS08710	COG0557	exoribonuclease II activity
ToN1_RS08720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ToN1_RS08725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ToN1_RS08730	COG2239	Acts as a magnesium transporter
ToN1_RS08735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ToN1_RS08740	COG0352	thiamine-phosphate diphosphorylase activity
ToN1_RS08745	COG0351	phosphomethylpyrimidine kinase
ToN1_RS08765	COG0840	transmembrane signaling receptor activity
ToN1_RS08770	COG2198	Histidine kinase
ToN1_RS08770	COG0643	Histidine kinase
ToN1_RS08775	COG0415	Belongs to the DNA photolyase family
ToN1_RS08780	COG1678	Uncharacterized ACR, COG1678
ToN1_RS08785	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ToN1_RS08790	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ToN1_RS08795	COG0540	Belongs to the ATCase OTCase family
ToN1_RS08805	COG1872	DUF167
ToN1_RS08810	COG0762	integral membrane protein
ToN1_RS08840	COG1981	membrane
ToN1_RS08845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ToN1_RS08855	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ToN1_RS08885	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ToN1_RS08905	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ToN1_RS08905	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ToN1_RS08920	COG2200	EAL domain
ToN1_RS08920	COG2199	diguanylate cyclase activity
ToN1_RS08930	COG2197	response regulator
ToN1_RS08935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ToN1_RS08940	COG2274	protein secretion by the type I secretion system
ToN1_RS08950	COG0735	belongs to the Fur family
ToN1_RS08960	COG1121	(ABC) transporter
ToN1_RS08970	COG0803	Belongs to the bacterial solute-binding protein 9 family
ToN1_RS08975	COG1280	lysine exporter protein (LysE YggA)
ToN1_RS08995	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ToN1_RS09000	COG0129	dihydroxy-acid dehydratase activity
ToN1_RS09005	COG3132	Protein of unknown function, DUF480
ToN1_RS09010	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ToN1_RS09070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ToN1_RS09075	COG0577	efflux transmembrane transporter activity
ToN1_RS09075	COG1136	(ABC) transporter
ToN1_RS09105	COG0672	)-iron permease
ToN1_RS09150	COG3781	membrane
ToN1_RS09180	COG5002	protein histidine kinase activity
ToN1_RS09210	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ToN1_RS09215	COG4969	Belongs to the N-Me-Phe pilin family
ToN1_RS09220	COG3307	-O-antigen
ToN1_RS09240	COG0436	Aminotransferase
ToN1_RS09245	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ToN1_RS09250	COG0235	Class ii aldolase
ToN1_RS09255	COG2084	Dehydrogenase
ToN1_RS09260	COG2084	Dehydrogenase
ToN1_RS09265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ToN1_RS09275	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ToN1_RS09285	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ToN1_RS09315	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ToN1_RS09330	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ToN1_RS09345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ToN1_RS09370	COG4647	ligase activity
ToN1_RS09375	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
ToN1_RS09380	COG0145	ligase activity
ToN1_RS09395	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ToN1_RS09425	COG0629	single-stranded DNA binding
ToN1_RS09430	COG2814	Major facilitator Superfamily
ToN1_RS09445	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ToN1_RS09450	COG0203	ribosomal protein L17
ToN1_RS09455	COG0202	RNA polymerase activity
ToN1_RS09460	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ToN1_RS09465	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ToN1_RS09470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ToN1_RS09475	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ToN1_RS09480	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ToN1_RS09485	COG0201	protein transport
ToN1_RS09490	COG0200	Binds to the 23S rRNA
ToN1_RS09495	COG1841	ribosomal large subunit assembly
ToN1_RS09500	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ToN1_RS09505	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ToN1_RS09510	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ToN1_RS09515	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ToN1_RS09520	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ToN1_RS09525	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ToN1_RS09530	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ToN1_RS09535	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ToN1_RS09540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ToN1_RS09545	COG0255	Belongs to the universal ribosomal protein uL29 family
ToN1_RS09550	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ToN1_RS09555	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ToN1_RS09560	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ToN1_RS09565	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ToN1_RS09570	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ToN1_RS09575	COG0089	rRNA binding
ToN1_RS09580	COG0088	Forms part of the polypeptide exit tunnel
ToN1_RS09585	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ToN1_RS09590	COG0051	transcription antitermination factor activity, RNA binding
ToN1_RS09595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ToN1_RS09600	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ToN1_RS09605	COG0049	tRNA binding
ToN1_RS09610	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ToN1_RS09615	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ToN1_RS09620	COG0085	RNA polymerase activity
ToN1_RS09625	COG0222	ribosome binding
ToN1_RS09630	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ToN1_RS09635	COG0081	regulation of translation
ToN1_RS09640	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ToN1_RS09650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ToN1_RS09660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ToN1_RS09680	COG0277	FAD linked oxidase domain protein
ToN1_RS09700	COG2197	response regulator
ToN1_RS09710	COG4999	Histidine kinase
ToN1_RS09710	COG3437	response regulator, receiver
ToN1_RS09710	COG3850	Histidine kinase
ToN1_RS09710	COG2205	protein histidine kinase activity
ToN1_RS09725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_RS09760	COG1022	Amp-dependent synthetase and ligase
ToN1_RS09795	COG0586	Pfam SNARE associated Golgi protein
ToN1_RS09800	COG5001	Diguanylate cyclase
ToN1_RS09800	COG4251	negative regulation of phosphorylation
ToN1_RS09800	COG3706	GGDEF domain
ToN1_RS09800	COG2203	Gaf domain
ToN1_RS09805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ToN1_RS09810	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ToN1_RS09810	COG1703	isobutyryl-CoA mutase activity
ToN1_RS09810	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ToN1_RS09840	COG3746	phosphate-selective porin O and P
ToN1_RS09855	COG2321	neutral zinc metallopeptidase
ToN1_RS09860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ToN1_RS09880	COG4770	biotin carboxylase activity
ToN1_RS09885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ToN1_RS09890	COG1703	isobutyryl-CoA mutase activity
ToN1_RS09895	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ToN1_RS09895	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ToN1_RS09900	COG1802	Transcriptional regulator
ToN1_RS09905	COG0114	fumarate hydratase activity
ToN1_RS09925	COG0745	RESPONSE REGULATOR receiver
ToN1_RS09965	COG4964	Belongs to the GSP D family
ToN1_RS10015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ToN1_RS10020	COG3162	membrane
ToN1_RS10025	COG1024	Enoyl-CoA hydratase
ToN1_RS10030	COG1492	cobalamin metabolic process
ToN1_RS10035	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ToN1_RS10045	COG1242	4 iron, 4 sulfur cluster binding
ToN1_RS10050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ToN1_RS10060	COG0513	Belongs to the DEAD box helicase family
ToN1_RS10085	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
ToN1_RS10125	COG0427	acetyl-CoA hydrolase
ToN1_RS10130	COG2030	dehydratase
ToN1_RS10135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ToN1_RS10145	COG0583	DNA-binding transcription factor activity
ToN1_RS10150	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS10155	COG0393	Putative heavy-metal-binding
ToN1_RS10160	COG1280	lysine exporter protein (LysE YggA)
ToN1_RS10175	COG0545	Peptidyl-prolyl cis-trans isomerase
ToN1_RS10190	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ToN1_RS10205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ToN1_RS10210	COG3474	cytochrome
ToN1_RS10220	COG1595	DNA-templated transcription, initiation
ToN1_RS10225	COG2197	response regulator
ToN1_RS10240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ToN1_RS10245	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ToN1_RS10250	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ToN1_RS10260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ToN1_RS10265	COG2186	Transcriptional regulator
ToN1_RS10270	COG2423	ornithine cyclodeaminase activity
ToN1_RS10275	COG0006	proline dipeptidase activity
ToN1_RS10280	COG0006	proline dipeptidase activity
ToN1_RS10285	COG3608	succinylglutamate desuccinylase aspartoacylase
ToN1_RS10295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ToN1_RS10305	COG0508	dehydrogenase complex catalyzes the overall conversion of
ToN1_RS10350	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ToN1_RS10380	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ToN1_RS10400	COG0067	glutamate synthase
ToN1_RS10400	COG0070	glutamate synthase
ToN1_RS10400	COG0069	glutamate synthase activity
ToN1_RS10405	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ToN1_RS10410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ToN1_RS10415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ToN1_RS10450	COG1965	Belongs to the frataxin family
ToN1_RS10500	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ToN1_RS10505	COG0284	orotidine-5'-phosphate decarboxylase activity
ToN1_RS10515	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ToN1_RS10520	COG3161	chorismate lyase activity
ToN1_RS10525	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ToN1_RS10535	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ToN1_RS10550	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ToN1_RS10575	COG1858	cytochrome C peroxidase
ToN1_RS10580	COG1741	Belongs to the pirin family
ToN1_RS10590	COG0183	Belongs to the thiolase family
ToN1_RS10595	COG1024	Enoyl-CoA hydratase
ToN1_RS10595	COG1250	3-hydroxyacyl-CoA dehydrogenase
ToN1_RS10600	COG2067	long-chain fatty acid transport protein
ToN1_RS10620	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS10630	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ToN1_RS10635	COG0583	DNA-binding transcription factor activity
ToN1_RS10640	COG0288	reversible hydration of carbon dioxide
ToN1_RS10650	COG4178	(ABC) transporter
ToN1_RS10660	COG0366	Alpha amylase catalytic
ToN1_RS10670	COG5265	(ABC) transporter
ToN1_RS10680	COG0252	asparaginase activity
ToN1_RS10685	COG0583	DNA-binding transcription factor activity
ToN1_RS10690	COG0730	response to heat
ToN1_RS10705	COG0175	sulfate reduction
ToN1_RS10715	COG0175	sulfate reduction
ToN1_RS10720	COG2895	sulfate adenylyltransferase (ATP) activity
ToN1_RS10735	COG0330	HflC and HflK could
ToN1_RS10750	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ToN1_RS10755	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ToN1_RS10765	COG0824	Thioesterase
ToN1_RS10785	COG0823	Involved in the tonB-independent uptake of proteins
ToN1_RS10800	COG0602	queuosine metabolic process
ToN1_RS10805	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ToN1_RS10815	COG2204	response regulator
ToN1_RS10830	COG3300	MHYT domain
ToN1_RS10830	COG5001	Diguanylate cyclase
ToN1_RS10835	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_RS10875	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ToN1_RS10880	COG1546	Belongs to the CinA family
ToN1_RS10885	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ToN1_RS10890	COG2137	regulation of response to DNA damage stimulus
ToN1_RS10895	COG1137	ATPase activity
ToN1_RS10900	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ToN1_RS10905	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ToN1_RS10915	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ToN1_RS10920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ToN1_RS10925	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ToN1_RS10930	COG0741	lytic transglycosylase activity
ToN1_RS10945	COG0617	tRNA 3'-terminal CCA addition
ToN1_RS10975	COG0037	tRNA processing
ToN1_RS10985	COG1238	metal cluster binding
ToN1_RS10990	COG0251	oxidation-reduction process
ToN1_RS11005	COG1132	(ABC) transporter
ToN1_RS11025	COG0243	molybdopterin cofactor binding
ToN1_RS11035	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ToN1_RS11040	COG0708	Exodeoxyribonuclease III
ToN1_RS11045	COG1917	Cupin 2, conserved barrel domain protein
ToN1_RS11045	COG2207	Transcriptional regulator
ToN1_RS11075	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ToN1_RS11080	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ToN1_RS11120	COG2814	Major facilitator Superfamily
ToN1_RS11135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ToN1_RS11155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ToN1_RS11175	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ToN1_RS11185	COG0861	Integral membrane protein TerC family
ToN1_RS11195	COG4206	TonB-dependent receptor
ToN1_RS11205	COG3876	Protein conserved in bacteria
ToN1_RS11215	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ToN1_RS11315	COG0179	Fumarylacetoacetate (FAA) hydrolase
ToN1_RS11320	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS11340	COG0826	peptidase U32
ToN1_RS11350	COG0826	peptidase U32
ToN1_RS11355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ToN1_RS11360	COG2814	Major facilitator Superfamily
ToN1_RS11365	COG0606	chelatase, subunit chli
ToN1_RS11380	COG0347	Belongs to the P(II) protein family
ToN1_RS11385	COG0004	ammonium transporteR
ToN1_RS11410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ToN1_RS11420	COG0488	(ABC) transporter
ToN1_RS11435	COG0697	spore germination
ToN1_RS11445	COG0189	ligase activity
ToN1_RS11455	COG0827	DNA restriction-modification system
ToN1_RS11455	COG0732	type I restriction modification DNA specificity domain
ToN1_RS11475	COG1404	Belongs to the peptidase S8 family
ToN1_RS11480	COG1561	YicC-like family, N-terminal region
ToN1_RS11485	COG0515	serine threonine protein kinase
ToN1_RS11485	COG2815	serine threonine protein kinase
ToN1_RS11490	COG0631	protein serine/threonine phosphatase activity
ToN1_RS11495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ToN1_RS11500	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ToN1_RS11505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ToN1_RS11510	COG0616	signal peptide processing
ToN1_RS11515	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ToN1_RS11520	COG2022	thiamine diphosphate biosynthetic process
ToN1_RS11535	COG2032	superoxide dismutase activity
ToN1_RS11545	COG0022	dehydrogenase e1 component
ToN1_RS11545	COG0508	dehydrogenase complex catalyzes the overall conversion of
ToN1_RS11550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ToN1_RS11555	COG1956	GAF domain-containing protein
ToN1_RS11565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ToN1_RS11600	COG2860	membrane
ToN1_RS11605	COG1970	mechanosensitive ion channel activity
ToN1_RS11610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ToN1_RS11615	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ToN1_RS11645	COG0840	transmembrane signaling receptor activity
ToN1_RS11655	COG4633	Protein conserved in bacteria
ToN1_RS11660	COG0672	)-iron permease
ToN1_RS11675	COG3383	formate dehydrogenase (NAD+) activity
ToN1_RS11690	COG0583	DNA-binding transcription factor activity
ToN1_RS11705	COG0840	transmembrane signaling receptor activity
ToN1_RS11720	COG1136	(ABC) transporter
ToN1_RS11760	COG3245	cytochrome
ToN1_RS11775	COG4566	intracellular signal transduction
ToN1_RS11815	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ToN1_RS11820	COG0321	lipoyl(octanoyl) transferase activity
ToN1_RS11825	COG2921	Belongs to the UPF0250 family
ToN1_RS11835	COG1686	Belongs to the peptidase S11 family
ToN1_RS11845	COG0772	Belongs to the SEDS family
ToN1_RS11850	COG0768	penicillin binding
ToN1_RS11865	COG1077	Cell shape determining protein MreB Mrl
ToN1_RS11870	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ToN1_RS11875	COG0154	amidase activity
ToN1_RS11885	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ToN1_RS11890	COG0121	glutamine amidotransferase
ToN1_RS11910	COG0745	RESPONSE REGULATOR receiver
ToN1_RS11920	COG2226	methyltransferase
ToN1_RS11935	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ToN1_RS11940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ToN1_RS11945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ToN1_RS11950	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ToN1_RS11955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ToN1_RS11960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ToN1_RS11970	COG0356	it plays a direct role in the translocation of protons across the membrane
ToN1_RS11980	COG1475	DNA binding
ToN1_RS11985	COG1192	Involved in chromosome partitioning
ToN1_RS11990	COG0357	Ribosomal RNA small subunit methyltransferase G
ToN1_RS11995	COG0445	tRNA wobble uridine modification
ToN1_RS12005	COG2824	Alkylphosphonate utilization operon protein PhnA
ToN1_RS12010	COG1126	abc transporter atp-binding protein
ToN1_RS12015	COG0765	amino acid transport
ToN1_RS12020	COG0765	amino acid transport
ToN1_RS12025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ToN1_RS12035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ToN1_RS12040	COG2373	Large extracellular alpha-helical protein
ToN1_RS12045	COG4953	penicillin-binding protein 1C
ToN1_RS12070	COG0437	4 iron, 4 sulfur cluster binding
ToN1_RS12075	COG0243	molybdopterin cofactor binding
ToN1_RS12075	COG3383	formate dehydrogenase (NAD+) activity
ToN1_RS12105	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ToN1_RS12110	COG0746	molybdenum cofactor guanylyltransferase activity
ToN1_RS12120	COG1763	Mo-molybdopterin cofactor biosynthetic process
ToN1_RS12125	COG2204	response regulator
ToN1_RS12130	COG4191	Histidine kinase
ToN1_RS12135	COG0501	Belongs to the peptidase M48B family
ToN1_RS12140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ToN1_RS12145	COG0242	peptide deformylase activity
ToN1_RS12155	COG0758	DNA mediated transformation
ToN1_RS12160	COG2922	Belongs to the Smg family
ToN1_RS12165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ToN1_RS12165	COG0551	DNA topoisomerase type I activity
ToN1_RS12170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ToN1_RS12180	COG4206	TonB-dependent receptor
ToN1_RS12185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ToN1_RS12190	COG3909	cytochrome
ToN1_RS12205	COG0583	DNA-binding transcription factor activity
ToN1_RS12225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ToN1_RS12235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ToN1_RS12245	COG1187	pseudouridine synthase activity
ToN1_RS12255	COG2974	May be involved in recombination
ToN1_RS12265	COG0745	RESPONSE REGULATOR receiver
ToN1_RS12270	COG4251	negative regulation of phosphorylation
ToN1_RS12275	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS12280	COG0583	DNA-binding transcription factor activity
ToN1_RS12285	COG3706	GGDEF domain
ToN1_RS12300	COG0686	Belongs to the AlaDH PNT family
ToN1_RS12335	COG3706	GGDEF domain
ToN1_RS12345	COG0655	NAD(P)H dehydrogenase (quinone) activity
ToN1_RS12370	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ToN1_RS12375	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ToN1_RS12380	COG0594	ribonuclease P activity
ToN1_RS12385	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ToN1_RS12390	COG0706	membrane insertase activity
ToN1_RS12395	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ToN1_RS12405	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ToN1_RS12420	COG5000	phosphorelay sensor kinase activity
ToN1_RS12425	COG2204	response regulator
ToN1_RS12430	COG0569	domain protein
ToN1_RS12440	COG0840	transmembrane signaling receptor activity
ToN1_RS12455	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ToN1_RS12485	COG3052	prosthetic group binding
ToN1_RS12490	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
ToN1_RS12520	COG3181	Tripartite tricarboxylate transporter family receptor
ToN1_RS12535	COG0861	Integral membrane protein TerC family
ToN1_RS12550	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ToN1_RS12555	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ToN1_RS12560	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ToN1_RS12565	COG0437	4 iron, 4 sulfur cluster binding
ToN1_RS12570	COG5557	Pfam Polysulphide reductase, NrfD
ToN1_RS12575	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ToN1_RS12580	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ToN1_RS12600	COG0375	protein maturation
ToN1_RS12610	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ToN1_RS12615	COG0298	carbon dioxide binding
ToN1_RS12620	COG0409	Hydrogenase expression formation protein
ToN1_RS12625	COG0309	Hydrogenase expression formation protein (HypE)
ToN1_RS12630	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ToN1_RS12630	COG1024	Enoyl-CoA hydratase
ToN1_RS12635	COG2204	response regulator
ToN1_RS12640	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ToN1_RS12680	COG2258	MOSC domain
ToN1_RS12720	COG1278	Cold shock
ToN1_RS12725	COG2329	Antibiotic biosynthesis monooxygenase
ToN1_RS12925	COG2814	Major facilitator Superfamily
ToN1_RS12940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ToN1_RS12965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ToN1_RS12970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ToN1_RS12975	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ToN1_RS12990	COG0488	(ABC) transporter
ToN1_RS13000	COG0826	peptidase U32
ToN1_RS13040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ToN1_RS13080	COG0411	ABC transporter
ToN1_RS13105	COG1773	rubredoxin
ToN1_RS13135	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS13150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ToN1_RS13160	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS13165	COG1024	Enoyl-CoA hydratase
ToN1_RS13170	COG1024	Enoyl-CoA hydratase
ToN1_RS13175	COG1309	transcriptional regulator
ToN1_RS13180	COG0500	methyltransferase
ToN1_RS13185	COG3001	Fructosamine kinase
ToN1_RS13210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ToN1_RS13225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ToN1_RS13275	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ToN1_RS13285	COG1176	ABC-type spermidine putrescine transport system, permease component I
ToN1_RS13290	COG1177	transmembrane transport
ToN1_RS13295	COG1132	(ABC) transporter
ToN1_RS13300	COG0628	permease
ToN1_RS13310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ToN1_RS13330	COG3204	pilus organization
ToN1_RS13340	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ToN1_RS13345	COG1074	ATP-dependent DNA helicase activity
ToN1_RS13350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ToN1_RS13355	COG4191	Histidine kinase
ToN1_RS13360	COG2204	response regulator
ToN1_RS13370	COG2165	general secretion pathway protein
ToN1_RS13405	COG4537	Required for transformation and DNA binding
ToN1_RS13410	COG1278	Cold shock
ToN1_RS13420	COG0330	HflC and HflK could
ToN1_RS13450	COG0477	Major facilitator Superfamily
ToN1_RS13460	COG1305	Transglutaminase-like
ToN1_RS13465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ToN1_RS13475	COG3045	CreA protein
ToN1_RS13485	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ToN1_RS13490	COG0484	heat shock protein binding
ToN1_RS13515	COG0194	GDP metabolic process
ToN1_RS13520	COG1758	RNA polymerase activity
ToN1_RS13525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ToN1_RS13530	COG0523	cobalamin synthesis protein
ToN1_RS13535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ToN1_RS13560	COG3850	Histidine kinase
ToN1_RS13565	COG2197	response regulator
ToN1_RS13580	COG0243	molybdopterin cofactor binding
ToN1_RS13585	COG0437	4 iron, 4 sulfur cluster binding
ToN1_RS13590	COG0348	domain, Protein
ToN1_RS13595	COG3043	anaerobic respiration
ToN1_RS13600	COG3005	denitrification pathway
ToN1_RS13605	COG4133	protoheme IX ABC transporter activity
ToN1_RS13610	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ToN1_RS13620	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ToN1_RS13625	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ToN1_RS13635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ToN1_RS13640	COG3088	subunit of a heme lyase
ToN1_RS13645	COG3088	subunit of a heme lyase
ToN1_RS13645	COG4235	cytochrome complex assembly
ToN1_RS13660	COG2010	Cytochrome c
ToN1_RS13670	COG2204	response regulator
ToN1_RS13675	COG4191	Histidine kinase
ToN1_RS13695	COG2132	Multicopper oxidase
ToN1_RS13700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ToN1_RS13705	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ToN1_RS13710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ToN1_RS13740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ToN1_RS13800	COG2010	Cytochrome c
ToN1_RS13840	COG1215	transferase activity, transferring glycosyl groups
ToN1_RS13850	COG0438	transferase activity, transferring glycosyl groups
ToN1_RS13880	COG0714	Associated with various cellular activities
ToN1_RS13895	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ToN1_RS13900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ToN1_RS13930	COG1032	radical SAM domain protein
ToN1_RS13955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ToN1_RS13975	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ToN1_RS13980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ToN1_RS14050	COG1024	Enoyl-CoA hydratase
ToN1_RS14055	COG1250	3-hydroxyacyl-CoA dehydrogenase
ToN1_RS14060	COG2050	protein possibly involved in aromatic compounds catabolism
ToN1_RS14070	COG3396	Phenylacetate-CoA oxygenase
ToN1_RS14075	COG3460	Phenylacetate-CoA oxygenase
ToN1_RS14080	COG3396	Phenylacetate-CoA oxygenase
ToN1_RS14085	COG2151	metal-sulfur cluster biosynthetic enzyme
ToN1_RS14090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ToN1_RS14125	COG0583	DNA-binding transcription factor activity
ToN1_RS14130	COG4191	Histidine kinase
ToN1_RS14135	COG4566	intracellular signal transduction
ToN1_RS14155	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ToN1_RS14175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ToN1_RS14190	COG0513	Belongs to the DEAD box helicase family
ToN1_RS14205	COG0596	Alpha beta hydrolase
ToN1_RS14210	COG3300	MHYT domain
ToN1_RS14210	COG5001	Diguanylate cyclase
ToN1_RS14220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ToN1_RS14225	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ToN1_RS14240	COG4232	protein-disulfide reductase activity
ToN1_RS14245	COG1324	tolerance protein
ToN1_RS14275	COG3279	Response regulator of the LytR AlgR family
ToN1_RS14285	COG2203	Gaf domain
ToN1_RS14285	COG3706	GGDEF domain
ToN1_RS14285	COG4251	negative regulation of phosphorylation
ToN1_RS14285	COG5001	Diguanylate cyclase
ToN1_RS14305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ToN1_RS14340	COG0861	Integral membrane protein TerC family
ToN1_RS14345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ToN1_RS14360	COG0348	domain, Protein
ToN1_RS14375	COG1131	(ABC) transporter
ToN1_RS14380	COG0625	glutathione transferase activity
ToN1_RS14400	COG3154	lipid carrier protein
ToN1_RS14405	COG0826	peptidase U32
ToN1_RS14410	COG0826	peptidase U32
ToN1_RS14430	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ToN1_RS14450	COG0346	lactoylglutathione lyase activity
ToN1_RS14470	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ToN1_RS14475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ToN1_RS14480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ToN1_RS14485	COG0018	arginyl-trna synthetase
ToN1_RS14500	COG0300	oxidoreductase activity
ToN1_RS14505	COG2902	Dehydrogenase
ToN1_RS14515	COG0826	peptidase U32
ToN1_RS14525	COG3158	transport of potassium into the cell
ToN1_RS14530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ToN1_RS14540	COG3243	poly(R)-hydroxyalkanoic acid synthase
ToN1_RS14545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ToN1_RS14550	COG0789	Transcriptional regulator
ToN1_RS14555	COG0288	reversible hydration of carbon dioxide
ToN1_RS14560	COG0183	Belongs to the thiolase family
ToN1_RS14565	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS14570	COG1024	Enoyl-CoA hydratase
ToN1_RS14590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ToN1_RS14595	COG1660	Displays ATPase and GTPase activities
ToN1_RS14610	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ToN1_RS14630	COG1301	dicarboxylic acid transport
ToN1_RS14640	COG1053	succinate dehydrogenase
ToN1_RS14645	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ToN1_RS14670	COG0217	transcriptional regulatory protein
ToN1_RS14680	COG0433	COG0433 Predicted ATPase
ToN1_RS14700	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ToN1_RS14700	COG0546	phosphoglycolate phosphatase activity
ToN1_RS14710	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS14720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ToN1_RS14745	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ToN1_RS14780	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ToN1_RS14790	COG1278	Cold shock
ToN1_RS14795	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ToN1_RS14820	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ToN1_RS14830	COG1560	Kdo2-lipid A biosynthetic process
ToN1_RS14835	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ToN1_RS14845	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ToN1_RS14855	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ToN1_RS14865	COG2255	four-way junction helicase activity
ToN1_RS14870	COG0632	four-way junction helicase activity
ToN1_RS14880	COG1530	ribonuclease E activity
ToN1_RS14885	COG0424	maF-like protein
ToN1_RS14905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ToN1_RS14910	COG0799	negative regulation of ribosome biogenesis
ToN1_RS14915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ToN1_RS14930	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ToN1_RS14955	COG2192	nodulation
ToN1_RS14960	COG0438	transferase activity, transferring glycosyl groups
ToN1_RS14995	COG1132	(ABC) transporter
ToN1_RS15000	COG1368	sulfuric ester hydrolase activity
ToN1_RS15025	COG0438	transferase activity, transferring glycosyl groups
ToN1_RS15030	COG0859	PFAM glycosyl transferase family 9
ToN1_RS15040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ToN1_RS15045	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ToN1_RS15045	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ToN1_RS15055	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ToN1_RS15060	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ToN1_RS15075	COG4206	TonB-dependent receptor
ToN1_RS15085	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ToN1_RS15095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ToN1_RS15095	COG1648	precorrin-2 dehydrogenase activity
ToN1_RS15105	COG2818	Glycosylase
ToN1_RS15110	COG0583	DNA-binding transcription factor activity
ToN1_RS15135	COG0247	lactate metabolic process
ToN1_RS15140	COG0697	spore germination
ToN1_RS15155	COG0583	DNA-binding transcription factor activity
ToN1_RS15160	COG1032	radical SAM domain protein
ToN1_RS15165	COG3023	N-Acetylmuramoyl-L-alanine amidase
ToN1_RS15170	COG0741	lytic transglycosylase activity
ToN1_RS15175	COG0436	Aminotransferase
ToN1_RS15180	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ToN1_RS15185	COG0280	phosphate acetyltransferase
ToN1_RS15185	COG0281	malic enzyme
ToN1_RS15205	COG1187	pseudouridine synthase activity
ToN1_RS15215	COG0577	efflux transmembrane transporter activity
ToN1_RS15215	COG1136	(ABC) transporter
ToN1_RS15225	COG1136	(ABC) transporter
ToN1_RS15225	COG0577	efflux transmembrane transporter activity
ToN1_RS15230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ToN1_RS15235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ToN1_RS15240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ToN1_RS15245	COG0493	'glutamate synthase
ToN1_RS15245	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ToN1_RS15260	COG4269	membrane
ToN1_RS15265	COG0501	Belongs to the peptidase M48B family
ToN1_RS15270	COG1643	Atp-dependent helicase
ToN1_RS15275	COG0360	Binds together with S18 to 16S ribosomal RNA
ToN1_RS15280	COG2965	DNA replication, synthesis of RNA primer
ToN1_RS15285	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ToN1_RS15290	COG0359	binds to the 23S rRNA
ToN1_RS15295	COG0305	Participates in initiation and elongation during chromosome replication
ToN1_RS15325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ToN1_RS15330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ToN1_RS15335	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ToN1_RS15345	COG0494	nUDIX hydrolase
ToN1_RS15350	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ToN1_RS15355	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ToN1_RS15360	COG0237	dephospho-CoA kinase activity
ToN1_RS15370	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
ToN1_RS15375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ToN1_RS15390	COG3852	Histidine kinase
ToN1_RS15400	COG0174	glutamine synthetase
ToN1_RS15415	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ToN1_RS15420	COG3568	Endonuclease Exonuclease Phosphatase
ToN1_RS15425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ToN1_RS15440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ToN1_RS15460	COG0463	Glycosyl transferase, family 2
ToN1_RS15475	COG0564	pseudouridine synthase activity
ToN1_RS15480	COG0012	GTP binding
ToN1_RS15485	COG0193	aminoacyl-tRNA hydrolase activity
ToN1_RS15490	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ToN1_RS15495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ToN1_RS15505	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ToN1_RS15510	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ToN1_RS15520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ToN1_RS15525	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ToN1_RS15530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ToN1_RS15535	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ToN1_RS15540	COG0742	ribosomal rna small subunit methyltransferase
ToN1_RS15550	COG0612	Peptidase, M16
ToN1_RS15560	COG2884	Cell division ATP-binding protein ftsE
ToN1_RS15565	COG2177	Part of the ABC transporter FtsEX involved in
ToN1_RS15575	COG0784	Response regulator, receiver
ToN1_RS15575	COG4191	Histidine kinase
ToN1_RS15585	COG2084	Dehydrogenase
ToN1_RS15590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ToN1_RS15600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ToN1_RS15605	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS15610	COG3958	Transketolase
ToN1_RS15615	COG3959	Transketolase, thiamine diphosphate binding domain
ToN1_RS15620	COG0583	DNA-binding transcription factor activity
ToN1_RS15640	COG1607	acyl-coa hydrolase
ToN1_RS15645	COG2703	oxygen carrier activity
ToN1_RS15650	COG3622	Belongs to the hyi family
ToN1_RS15655	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ToN1_RS15660	COG0251	oxidation-reduction process
ToN1_RS15665	COG1250	3-hydroxyacyl-CoA dehydrogenase
ToN1_RS15670	COG0183	Belongs to the thiolase family
ToN1_RS15680	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS15685	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS15690	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS15695	COG1053	succinate dehydrogenase
ToN1_RS15725	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS15730	COG4638	Rieske (2fe-2S)
ToN1_RS15735	COG0604	alcohol dehydrogenase
ToN1_RS15750	COG4447	cellulose binding
ToN1_RS15785	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ToN1_RS15790	COG0022	dehydrogenase e1 component
ToN1_RS15795	COG0508	dehydrogenase complex catalyzes the overall conversion of
ToN1_RS15800	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS15805	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS15820	COG1024	Enoyl-CoA hydratase
ToN1_RS15830	COG1309	transcriptional regulator
ToN1_RS15835	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS15845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ToN1_RS15850	COG1702	phosphate starvation-inducible protein PhoH
ToN1_RS15855	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ToN1_RS15860	COG4535	Mg2 and Co2 transporter CorC
ToN1_RS15865	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ToN1_RS15870	COG0752	glycyl-tRNA synthetase alpha subunit
ToN1_RS15875	COG0751	glycine-tRNA ligase activity
ToN1_RS15880	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ToN1_RS15885	COG0204	Acyl-transferase
ToN1_RS15905	COG1024	Enoyl-CoA hydratase
ToN1_RS15910	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ToN1_RS15930	COG1127	ABC transporter
ToN1_RS15935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ToN1_RS15940	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ToN1_RS15960	COG1131	(ABC) transporter
ToN1_RS15965	COG0842	Transport permease protein
ToN1_RS15975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ToN1_RS15980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ToN1_RS15985	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ToN1_RS15990	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ToN1_RS15995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ToN1_RS16000	COG0131	Imidazoleglycerol-phosphate dehydratase
ToN1_RS16005	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ToN1_RS16010	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ToN1_RS16015	COG0107	imidazoleglycerol-phosphate synthase activity
ToN1_RS16020	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ToN1_RS16025	COG0140	phosphoribosyl-ATP diphosphatase activity
ToN1_RS16035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ToN1_RS16040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ToN1_RS16045	COG0805	protein transport
ToN1_RS16055	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ToN1_RS16070	COG0045	succinate-CoA ligase (ADP-forming) activity
ToN1_RS16075	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ToN1_RS16080	COG3485	protocatechuate 3,4-dioxygenase
ToN1_RS16090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ToN1_RS16100	COG0306	phosphate transporter
ToN1_RS16120	COG0105	UTP biosynthetic process
ToN1_RS16125	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ToN1_RS16135	COG1426	Protein conserved in bacteria
ToN1_RS16140	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ToN1_RS16145	COG0124	histidyl-tRNA synthetase
ToN1_RS16150	COG2976	Protein conserved in bacteria
ToN1_RS16155	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ToN1_RS16160	COG1160	GTP binding
ToN1_RS16165	COG1923	regulation of RNA biosynthetic process
ToN1_RS16170	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ToN1_RS16175	COG0330	HflC and HflK could
ToN1_RS16180	COG0330	HflC and HflK could
ToN1_RS16190	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ToN1_RS16195	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ToN1_RS16210	COG0557	exoribonuclease II activity
ToN1_RS16215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ToN1_RS16220	COG3707	response regulator
ToN1_RS16225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ToN1_RS16235	COG1116	anion transmembrane transporter activity
ToN1_RS16250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ToN1_RS16260	COG2223	nitrite transmembrane transporter activity
ToN1_RS16265	COG2815	serine threonine protein kinase
ToN1_RS16265	COG0515	serine threonine protein kinase
ToN1_RS16270	COG0243	molybdopterin cofactor binding
ToN1_RS16285	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ToN1_RS16290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ToN1_RS16295	COG2252	PERMEase
ToN1_RS16300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ToN1_RS16310	COG1752	Esterase of the alpha-beta hydrolase superfamily
ToN1_RS16315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ToN1_RS16330	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ToN1_RS16335	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ToN1_RS16340	COG0723	plastoquinol--plastocyanin reductase activity
ToN1_RS16345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ToN1_RS16350	COG2857	Cytochrome c1
ToN1_RS16355	COG0625	glutathione transferase activity
ToN1_RS16360	COG2969	positive regulation of protein catabolic process
ToN1_RS16365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ToN1_RS16370	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ToN1_RS16410	COG1595	DNA-templated transcription, initiation
ToN1_RS16430	COG3220	belongs to the UPF0276 family
ToN1_RS16440	COG1448	Aminotransferase
ToN1_RS16445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_RS16460	COG0679	Auxin Efflux Carrier
ToN1_RS16465	COG3437	response regulator, receiver
ToN1_RS16500	COG4566	intracellular signal transduction
ToN1_RS16505	COG3706	GGDEF domain
ToN1_RS16530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ToN1_RS16535	COG4191	Histidine kinase
ToN1_RS16540	COG1100	Small GTP-binding protein
ToN1_RS16555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ToN1_RS16560	COG0459	protein refolding
ToN1_RS16570	COG0642	Histidine kinase
ToN1_RS16575	COG3162	membrane
ToN1_RS16615	COG1111	helicase
ToN1_RS16615	COG1205	dead DEAH box helicase
ToN1_RS16635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ToN1_RS16645	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ToN1_RS16700	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ToN1_RS16705	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ToN1_RS16710	COG2890	protein-(glutamine-N5) methyltransferase activity
ToN1_RS16715	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ToN1_RS16740	COG0165	Argininosuccinate lyase
ToN1_RS16750	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ToN1_RS16755	COG0181	hydroxymethylbilane synthase activity
ToN1_RS16765	COG2959	enzyme of heme biosynthesis
ToN1_RS16775	COG0408	coproporphyrinogen oxidase activity
ToN1_RS16780	COG0151	Belongs to the GarS family
ToN1_RS16790	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ToN1_RS16795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ToN1_RS16805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ToN1_RS16810	COG0006	proline dipeptidase activity
ToN1_RS16825	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ToN1_RS16830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ToN1_RS16835	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ToN1_RS16840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ToN1_RS16850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ToN1_RS16865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ToN1_RS16895	COG0489	protein tyrosine kinase activity
ToN1_RS16930	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ToN1_RS16940	COG1696	Membrane protein involved in D-alanine export
ToN1_RS16945	COG0438	transferase activity, transferring glycosyl groups
ToN1_RS16950	COG2244	polysaccharide biosynthetic process
ToN1_RS16955	COG2327	Polysaccharide pyruvyl transferase
ToN1_RS16965	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ToN1_RS16985	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ToN1_RS16995	COG2885	chlorophyll binding
ToN1_RS17000	COG5001	Diguanylate cyclase
ToN1_RS17000	COG5002	protein histidine kinase activity
ToN1_RS17030	COG0778	Nitroreductase
ToN1_RS17035	COG0469	pyruvate kinase activity
ToN1_RS17050	COG0126	phosphoglycerate kinase activity
ToN1_RS17055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ToN1_RS17060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ToN1_RS17065	COG3954	Phosphoribulokinase
ToN1_RS17075	COG0483	inositol monophosphate 1-phosphatase activity
ToN1_RS17080	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ToN1_RS17090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ToN1_RS17090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ToN1_RS17095	COG5001	Diguanylate cyclase
ToN1_RS17095	COG5002	protein histidine kinase activity
ToN1_RS17095	COG3447	MASE1 domain protein
ToN1_RS17100	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ToN1_RS17110	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ToN1_RS17115	COG0303	'Molybdopterin
ToN1_RS17125	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ToN1_RS17135	COG0546	phosphoglycolate phosphatase activity
ToN1_RS17140	COG2226	methyltransferase
ToN1_RS17145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ToN1_RS17150	COG1040	competence protein
ToN1_RS17155	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ToN1_RS17160	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ToN1_RS17170	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ToN1_RS17180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ToN1_RS17185	COG0640	Transcriptional regulator
ToN1_RS17190	COG0588	phosphoglycerate mutase activity
ToN1_RS17200	COG0793	Belongs to the peptidase S41A family
ToN1_RS17215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ToN1_RS17215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ToN1_RS17220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ToN1_RS17225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ToN1_RS17235	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ToN1_RS17245	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ToN1_RS17250	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ToN1_RS17255	COG0312	modulator of DNA gyrase
ToN1_RS17260	COG3028	Belongs to the UPF0307 family
ToN1_RS17265	COG0521	Mo-molybdopterin cofactor biosynthetic process
ToN1_RS17270	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ToN1_RS17275	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ToN1_RS17290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ToN1_RS17295	COG2096	Adenosyltransferase
ToN1_RS17305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ToN1_RS17345	COG0482	sulfurtransferase activity
ToN1_RS17370	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ToN1_RS17385	COG0312	modulator of DNA gyrase
ToN1_RS17395	COG2204	response regulator
ToN1_RS17405	COG2205	protein histidine kinase activity
ToN1_RS17420	COG0741	lytic transglycosylase activity
ToN1_RS17425	COG0442	prolyl-tRNA aminoacylation
ToN1_RS17430	COG0494	nUDIX hydrolase
ToN1_RS17440	COG1592	Rubrerythrin
ToN1_RS17445	COG0247	lactate metabolic process
ToN1_RS17460	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ToN1_RS17465	COG1765	OsmC-like protein
ToN1_RS17470	COG3033	Beta-eliminating lyase
ToN1_RS17475	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ToN1_RS17480	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ToN1_RS17485	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ToN1_RS17490	COG0316	Belongs to the HesB IscA family
ToN1_RS17495	COG1196	nuclear chromosome segregation
ToN1_RS17495	COG0739	heme binding
ToN1_RS17495	COG0741	lytic transglycosylase activity
ToN1_RS17500	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ToN1_RS17555	COG0010	Belongs to the arginase family
ToN1_RS17560	COG1228	amidohydrolase
ToN1_RS17575	COG2423	ornithine cyclodeaminase activity
ToN1_RS17580	COG0583	DNA-binding transcription factor activity
ToN1_RS17625	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS17630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ToN1_RS17635	COG4770	biotin carboxylase activity
ToN1_RS17640	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_RS17650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ToN1_RS17655	COG0402	S-adenosylhomocysteine deaminase activity
ToN1_RS17680	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ToN1_RS17695	COG2201	protein-glutamate methylesterase activity
ToN1_RS17700	COG0784	Response regulator, receiver
ToN1_RS17700	COG0835	chemotaxis
ToN1_RS17705	COG0784	Response regulator, receiver
ToN1_RS17705	COG0835	chemotaxis
ToN1_RS17710	COG0745	RESPONSE REGULATOR receiver
ToN1_RS17715	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ToN1_RS17720	COG0784	Response regulator, receiver
ToN1_RS17720	COG0643	Histidine kinase
ToN1_RS17720	COG2198	Histidine kinase
ToN1_RS17730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ToN1_RS17735	COG0583	DNA-binding transcription factor activity
ToN1_RS17740	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ToN1_RS17745	COG4208	sulfate ABC transporter
ToN1_RS17750	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ToN1_RS17760	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ToN1_RS17765	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ToN1_RS17770	COG1570	exodeoxyribonuclease VII activity
ToN1_RS17780	COG0811	peptide transport
ToN1_RS17785	COG0848	biopolymer transport protein
ToN1_RS17790	COG1663	tetraacyldisaccharide 4'-kinase activity
ToN1_RS17795	COG2835	tetraacyldisaccharide 4'-kinase activity
ToN1_RS17800	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ToN1_RS17805	COG0563	adenylate kinase activity
ToN1_RS17810	COG0205	6-phosphofructokinase activity
ToN1_RS17820	COG1881	PFAM PEBP family protein
ToN1_RS17830	COG0268	Binds directly to 16S ribosomal RNA
ToN1_RS17840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ToN1_RS17845	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ToN1_RS17850	COG0137	argininosuccinate synthase activity
ToN1_RS17860	COG3123	guanosine phosphorylase activity
ToN1_RS17865	COG1666	GTP binding
ToN1_RS17875	COG4968	Prepilin-type N-terminal cleavage methylation domain
ToN1_RS17910	COG0745	RESPONSE REGULATOR receiver
ToN1_RS17910	COG2972	Histidine kinase
ToN1_RS17920	COG0494	nUDIX hydrolase
ToN1_RS17930	COG2217	Heavy metal translocating P-type atpase
ToN1_RS17940	COG3278	Belongs to the heme-copper respiratory oxidase family
ToN1_RS17960	COG0348	domain, Protein
ToN1_RS17980	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ToN1_RS17985	COG3243	poly(R)-hydroxyalkanoic acid synthase
ToN1_RS18010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ToN1_RS18015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ToN1_RS18030	COG2217	Heavy metal translocating P-type atpase
ToN1_RS18045	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ToN1_RS18055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ToN1_RS18055	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ToN1_RS18065	COG2840	Smr protein MutS2
ToN1_RS18070	COG0492	ferredoxin-NADP+ reductase activity
ToN1_RS18080	COG1674	ftsk spoiiie
ToN1_RS18085	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ToN1_RS18090	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ToN1_RS18100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ToN1_RS18105	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ToN1_RS18130	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ToN1_RS18135	COG2951	lytic endotransglycosylase activity
ToN1_RS18150	COG0564	pseudouridine synthase activity
ToN1_RS18165	COG3243	poly(R)-hydroxyalkanoic acid synthase
ToN1_RS18170	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS18185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ToN1_RS18190	COG1752	Esterase of the alpha-beta hydrolase superfamily
ToN1_RS18195	COG0277	FAD linked oxidase domain protein
ToN1_RS18230	COG1250	3-hydroxyacyl-CoA dehydrogenase
ToN1_RS18235	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ToN1_RS18245	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ToN1_RS18250	COG0517	IMP dehydrogenase activity
ToN1_RS18250	COG0617	tRNA 3'-terminal CCA addition
ToN1_RS18250	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ToN1_RS18255	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_RS18260	COG0028	Belongs to the TPP enzyme family
ToN1_RS18265	COG0440	acetolactate synthase activity
ToN1_RS18270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ToN1_RS18275	COG2814	Major facilitator Superfamily
ToN1_RS18285	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ToN1_RS18290	COG0066	3-isopropylmalate dehydratase activity
ToN1_RS18295	COG0473	3-isopropylmalate dehydrogenase activity
ToN1_RS18310	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ToN1_RS18315	COG0101	tRNA pseudouridine synthase activity
ToN1_RS18320	COG0135	phosphoribosylanthranilate isomerase activity
ToN1_RS18325	COG0133	tryptophan synthase activity
ToN1_RS18330	COG0159	tryptophan synthase activity
ToN1_RS18335	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ToN1_RS18340	COG0285	dihydrofolate synthase activity
ToN1_RS18365	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ToN1_RS18370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ToN1_RS18390	COG0215	cysteine-tRNA ligase activity
ToN1_RS18395	COG0484	heat shock protein binding
ToN1_RS18400	COG0443	Heat shock 70 kDa protein
ToN1_RS18405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ToN1_RS18410	COG0515	serine threonine protein kinase
ToN1_RS18410	COG2815	serine threonine protein kinase
ToN1_RS18420	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ToN1_RS18425	COG1420	regulation of RNA biosynthetic process
ToN1_RS18430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ToN1_RS18435	COG0497	DNA recombination
ToN1_RS18440	COG0735	belongs to the Fur family
ToN1_RS18445	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ToN1_RS18450	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ToN1_RS18455	COG0505	Belongs to the CarA family
ToN1_RS18460	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ToN1_RS18465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ToN1_RS18475	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ToN1_RS18480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ToN1_RS18490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ToN1_RS18495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ToN1_RS18500	COG0573	inorganic phosphate transmembrane transporter activity
ToN1_RS18505	COG0573	inorganic phosphate transmembrane transporter activity
ToN1_RS18510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ToN1_RS18515	COG0149	triose-phosphate isomerase activity
ToN1_RS18530	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ToN1_RS18535	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ToN1_RS18540	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ToN1_RS18545	COG0649	NAD binding
ToN1_RS18550	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ToN1_RS18560	COG1034	ATP synthesis coupled electron transport
ToN1_RS18565	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ToN1_RS18570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ToN1_RS18580	COG0713	ATP synthesis coupled electron transport
ToN1_RS18595	COG1007	ATP synthesis coupled electron transport
ToN1_RS18605	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ToN1_RS18610	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ToN1_RS18615	COG3383	formate dehydrogenase (NAD+) activity
ToN1_RS18620	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
ToN1_RS18625	COG3259	Nickel-dependent hydrogenase
ToN1_RS18675	COG3193	protein, possibly involved in utilization of glycolate and propanediol
ToN1_RS18715	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_RS18740	COG1132	(ABC) transporter
ToN1_RS18760	COG1027	Aspartate ammonia-lyase
ToN1_RS18815	COG1490	D-aminoacyl-tRNA deacylase activity
ToN1_RS18835	COG3384	dioxygenase
ToN1_RS18840	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ToN1_RS18845	COG0183	Belongs to the thiolase family
ToN1_RS18850	COG1162	GTPase activity
ToN1_RS18855	COG0501	Belongs to the peptidase M48B family
ToN1_RS18860	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ToN1_RS18870	COG0254	rRNA binding
ToN1_RS18880	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ToN1_RS18885	COG3012	SEC-C Motif Domain Protein
ToN1_RS18885	COG3318	Belongs to the UPF0149 family
ToN1_RS18920	COG3012	SEC-C Motif Domain Protein
ToN1_RS18925	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ToN1_RS18935	COG0668	transmembrane transport
ToN1_RS18940	COG1363	Peptidase, m42
ToN1_RS18950	COG0367	asparagine synthase
ToN1_RS18955	COG0791	NLP P60 protein
ToN1_RS18970	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ToN1_RS18975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ToN1_RS18985	COG0436	Aminotransferase
ToN1_RS19005	COG0697	spore germination
ToN1_RS19015	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ToN1_RS19015	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ToN1_RS19020	COG2719	SpoVR family
ToN1_RS19030	COG2766	serine protein kinase
ToN1_RS19035	COG0544	peptidyl-prolyl cis-trans isomerase activity
ToN1_RS19040	COG0740	serine-type endopeptidase activity
ToN1_RS19045	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ToN1_RS19050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ToN1_RS19075	COG0242	peptide deformylase activity
ToN1_RS19080	COG1595	DNA-templated transcription, initiation
ToN1_RS19090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ToN1_RS19095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ToN1_RS19110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ToN1_RS19125	COG2204	response regulator
ToN1_RS19220	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_RS19245	COG4628	conserved protein (DUF2132)
ToN1_RS19255	COG0674	pyruvate-flavodoxin oxidoreductase activity
ToN1_RS19255	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ToN1_RS19260	COG1013	pyruvate-flavodoxin oxidoreductase activity
ToN1_RS19265	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ToN1_RS19275	COG2814	Major facilitator Superfamily
ToN1_RS19280	COG3327	negative regulation of DNA-templated transcription, initiation
ToN1_RS19285	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ToN1_RS19290	COG0243	molybdopterin cofactor binding
ToN1_RS19360	COG2153	protein acetylation
ToN1_RS19380	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ToN1_RS19385	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ToN1_RS19400	COG0084	hydrolase, TatD family'
ToN1_RS19465	COG1558	bacterial-type flagellum-dependent cell motility
ToN1_RS19470	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ToN1_RS19490	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ToN1_RS19495	COG1706	bacterial-type flagellum-dependent cell motility
ToN1_RS19520	COG1684	flagellar biosynthetic protein fliR
ToN1_RS19530	COG1338	Plays a role in the flagellum-specific transport system
ToN1_RS19545	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ToN1_RS19565	COG1157	protein secretion by the type III secretion system
ToN1_RS19580	COG1766	The M ring may be actively involved in energy transduction
ToN1_RS19595	COG1677	Flagellar hook-basal body complex protein FliE
ToN1_RS19600	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ToN1_RS19605	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ToN1_RS19625	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ToN1_RS19630	COG1334	flagellar protein FlaG
ToN1_RS19650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ToN1_RS19655	COG0508	dehydrogenase complex catalyzes the overall conversion of
ToN1_RS19660	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ToN1_RS19675	COG4566	intracellular signal transduction
ToN1_RS19685	COG0840	transmembrane signaling receptor activity
ToN1_RS19700	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ToN1_RS19705	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ToN1_RS19710	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ToN1_RS19715	COG0009	L-threonylcarbamoyladenylate synthase
ToN1_RS19800	COG1199	ATP-dependent helicase activity
ToN1_RS19800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ToN1_RS19810	COG4303	Ethanolamine ammonia lyase large subunit
ToN1_RS19830	COG2814	Major facilitator Superfamily
ToN1_RS19835	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ToN1_RS19840	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ToN1_RS19845	COG0583	DNA-binding transcription factor activity
ToN1_RS19850	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_RS19870	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ToN1_RS19870	COG1796	DNA polymerase
ToN1_RS19895	COG0484	heat shock protein binding
ToN1_RS19905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ToN1_RS19910	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ToN1_RS19915	COG0022	dehydrogenase e1 component
ToN1_RS19915	COG0508	dehydrogenase complex catalyzes the overall conversion of
ToN1_RS19930	COG0668	transmembrane transport
ToN1_RS19975	COG4772	TonB-dependent receptor
ToN1_RS19985	COG1944	ATP diphosphatase activity
ToN1_RS20015	COG0386	Belongs to the glutathione peroxidase family
ToN1_RS20100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ToN1_RS20130	COG3138	arginine N-succinyltransferase
ToN1_RS20140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ToN1_RS20155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ToN1_RS20155	COG2111	Na H antiporter
ToN1_RS20160	COG1006	Multisubunit Na H antiporter MnhC subunit
ToN1_RS20165	COG0651	ATP synthesis coupled electron transport
ToN1_RS20170	COG1863	multisubunit Na H antiporter MnhE subunit
ToN1_RS20175	COG2212	antiporter activity
ToN1_RS20180	COG1320	monovalent cation:proton antiporter activity
ToN1_RS20185	COG0583	DNA-binding transcription factor activity
ToN1_RS20210	COG1509	lysine 2,3-aminomutase activity
ToN1_RS20215	COG0604	alcohol dehydrogenase
ToN1_RS20225	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ToN1_RS20230	COG5012	cobalamin binding
ToN1_RS20235	COG1607	acyl-coa hydrolase
ToN1_RS20240	COG3246	L-lysine catabolic process to acetate
ToN1_RS20270	COG0459	protein refolding
ToN1_RS20275	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ToN1_RS20305	COG0010	Belongs to the arginase family
ToN1_RS20310	COG5006	permease, DMT superfamily
ToN1_RS20315	COG3284	Transcriptional regulator
ToN1_RS20320	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_RS20330	COG3284	Transcriptional regulator
ToN1_RS20335	COG2197	response regulator
ToN1_RS20340	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_RS20380	COG1131	(ABC) transporter
ToN1_RS20410	COG3284	Transcriptional regulator
ToN1_RS20420	COG2414	aldehyde ferredoxin oxidoreductase
ToN1_RS20425	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ToN1_RS20445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ToN1_RS20450	COG0583	DNA-binding transcription factor activity
ToN1_RS20460	COG3038	cytochrome b561
ToN1_RS20465	COG2353	YceI-like domain
ToN1_RS20470	COG2353	YceI-like domain
ToN1_RS20500	COG0315	cyclic pyranopterin monophosphate synthase activity
ToN1_RS20510	COG0425	Belongs to the sulfur carrier protein TusA family
ToN1_RS20515	COG0525	valine-tRNA ligase activity
ToN1_RS20530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ToN1_RS20535	COG0795	lipopolysaccharide-transporting ATPase activity
ToN1_RS20555	COG1959	2 iron, 2 sulfur cluster binding
ToN1_RS20565	COG2814	Major facilitator Superfamily
ToN1_RS20570	COG0583	DNA-binding transcription factor activity
ToN1_RS20575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ToN1_RS20580	COG0564	pseudouridine synthase activity
ToN1_RS20595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ToN1_RS20610	COG0798	PFAM Bile acid sodium symporter
ToN1_RS20615	COG2204	response regulator
ToN1_RS20620	COG4191	Histidine kinase
ToN1_RS20640	COG0243	molybdopterin cofactor binding
ToN1_RS20715	COG1473	amidohydrolase
ToN1_RS20720	COG0583	DNA-binding transcription factor activity
ToN1_RS20725	COG0583	DNA-binding transcription factor activity
ToN1_RS20730	COG0509	glycine decarboxylation via glycine cleavage system
ToN1_RS20740	COG2716	regulation of RNA biosynthetic process
ToN1_RS20745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ToN1_RS20750	COG1113	amino acid transport
ToN1_RS20755	COG1760	l-serine dehydratase
ToN1_RS20760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ToN1_RS20765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ToN1_RS20775	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ToN1_RS20780	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ToN1_RS20785	COG0604	alcohol dehydrogenase
ToN1_RS20790	COG1671	Belongs to the UPF0178 family
ToN1_RS20795	COG3048	D-serine ammonia-lyase activity
ToN1_RS20810	COG4657	Part of a membrane complex involved in electron transport
ToN1_RS20815	COG2878	Part of a membrane complex involved in electron transport
ToN1_RS20820	COG4656	Part of a membrane complex involved in electron transport
ToN1_RS20830	COG4659	FMN binding
ToN1_RS20840	COG2914	Belongs to the UPF0125 (RnfH) family
ToN1_RS20875	COG2072	flavoprotein involved in K transport
ToN1_RS20880	COG0625	glutathione transferase activity
ToN1_RS20890	COG0589	response to stress
ToN1_RS20895	COG0494	nUDIX hydrolase
ToN1_RS20900	COG1011	Hydrolase
ToN1_RS20905	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ToN1_RS21000	COG0583	DNA-binding transcription factor activity
ToN1_RS21005	COG1295	ribonuclease BN
ToN1_RS21015	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ToN1_RS21040	COG1122	ATPase activity
ToN1_RS21090	COG0674	pyruvate-flavodoxin oxidoreductase activity
ToN1_RS21090	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ToN1_RS21095	COG1013	pyruvate-flavodoxin oxidoreductase activity
ToN1_RS21100	COG0179	Fumarylacetoacetate (FAA) hydrolase
ToN1_RS21115	COG2271	Major facilitator Superfamily
ToN1_RS21145	COG0513	Belongs to the DEAD box helicase family
ToN1_RS21150	COG1451	nucleotide metabolic process
ToN1_RS21155	COG1024	Enoyl-CoA hydratase
ToN1_RS21160	COG0346	lactoylglutathione lyase activity
ToN1_RS21170	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ToN1_RS21175	COG0148	phosphopyruvate hydratase activity
ToN1_RS21180	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_RS21190	COG2017	converts alpha-aldose to the beta-anomer
ToN1_RS21195	COG0800	Aldolase
ToN1_RS21205	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ToN1_RS21215	COG1737	Transcriptional regulator
ToN1_RS21220	COG0166	Belongs to the GPI family
ToN1_RS21240	COG2207	Transcriptional regulator
ToN1_RS21255	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ToN1_RS21260	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
ToN1_RS21270	COG0535	radical SAM domain protein
ToN1_RS21280	COG2259	Doxx family
ToN1_RS21285	COG3284	Transcriptional regulator
ToN1_RS21300	COG0095	Lipoate-protein ligase
ToN1_RS21315	COG0022	dehydrogenase e1 component
ToN1_RS21320	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ToN1_RS21340	COG1879	ABC-type sugar transport system periplasmic component
ToN1_RS21345	COG1172	Belongs to the binding-protein-dependent transport system permease family
ToN1_RS21360	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ToN1_RS21385	COG1902	pentaerythritol trinitrate reductase activity
ToN1_RS21410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ToN1_RS21430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ToN1_RS21435	COG0837	glucose binding
ToN1_RS21440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ToN1_RS21460	COG1917	Cupin 2, conserved barrel domain protein
ToN1_RS21460	COG4977	sequence-specific DNA binding
ToN1_RS21470	COG0673	inositol 2-dehydrogenase activity
ToN1_RS21490	COG0366	Alpha amylase catalytic
ToN1_RS21495	COG1653	transport
ToN1_RS21535	COG2770	Histidine kinase
ToN1_RS21535	COG3437	response regulator, receiver
ToN1_RS21580	COG2010	Cytochrome c
ToN1_RS21610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ToN1_RS21620	COG5002	protein histidine kinase activity
ToN1_RS21625	COG0745	RESPONSE REGULATOR receiver
ToN1_RS21630	COG2176	DNA-directed DNA polymerase activity
ToN1_RS21630	COG5002	protein histidine kinase activity
ToN1_RS21635	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ToN1_RS21650	COG5598	trimethylamine methyltransferase
ToN1_RS21655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ToN1_RS21670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ToN1_RS21700	COG0446	pyridine nucleotide-disulphide oxidoreductase
ToN1_RS21700	COG1902	pentaerythritol trinitrate reductase activity
ToN1_RS21705	COG0247	lactate metabolic process
ToN1_RS21705	COG2181	nitrate reductase activity
ToN1_RS21710	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ToN1_RS21725	COG2113	Glycine betaine
ToN1_RS21775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ToN1_RS21790	COG0583	DNA-binding transcription factor activity
ToN1_RS21800	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_RS21825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ToN1_RS21825	COG0543	2 iron, 2 sulfur cluster binding
ToN1_RS21835	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ToN1_RS21840	COG3383	formate dehydrogenase (NAD+) activity
ToN1_RS21880	COG4175	Glycine betaine
ToN1_RS21890	COG1309	transcriptional regulator
ToN1_RS21900	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ToN1_RS21910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ToN1_RS21915	COG0285	dihydrofolate synthase activity
ToN1_RS21920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ToN1_RS21930	COG5012	cobalamin binding
ToN1_RS21965	COG5012	cobalamin binding
ToN1_RS21970	COG0646	methionine synthase
ToN1_RS21970	COG1410	methionine synthase
ToN1_RS21980	COG1469	GTP cyclohydrolase I activity
ToN1_RS21990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ToN1_RS21995	COG1760	l-serine dehydratase
ToN1_RS22025	COG2223	nitrite transmembrane transporter activity
ToN1_RS22050	COG2885	chlorophyll binding
ToN1_RS22070	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ToN1_RS22075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ToN1_RS22090	COG2009	succinate dehydrogenase
ToN1_RS22100	COG2200	EAL domain
ToN1_RS22100	COG2202	Pas domain
ToN1_RS22100	COG2199	diguanylate cyclase activity
ToN1_RS22130	COG1611	Belongs to the LOG family
ToN1_RS22145	COG2353	YceI-like domain
ToN1_RS22165	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ToN1_RS22175	COG4208	sulfate ABC transporter
ToN1_RS22180	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ToN1_RS22185	COG0530	calcium, potassium:sodium antiporter activity
ToN1_RS22200	COG0446	pyridine nucleotide-disulphide oxidoreductase
ToN1_RS22205	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ToN1_RS22215	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ToN1_RS22220	COG2078	PFAM AMMECR1 domain protein
ToN1_RS22225	COG1355	regulation of microtubule-based process
ToN1_RS22235	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ToN1_RS22240	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ToN1_RS22270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ToN1_RS22280	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ToN1_RS22285	COG0248	Ppx GppA phosphatase
ToN1_RS22290	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ToN1_RS22295	COG1127	ABC transporter
ToN1_RS22315	COG0084	hydrolase, TatD family'
ToN1_RS22320	COG1309	transcriptional regulator
ToN1_RS22335	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS22340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ToN1_RS22345	COG0271	Belongs to the BolA IbaG family
ToN1_RS22350	COG2350	Protein conserved in bacteria
ToN1_RS22355	COG2917	probably involved in intracellular septation
ToN1_RS22370	COG1214	PFAM Peptidase M22, glycoprotease
ToN1_RS22380	COG1573	uracil-dna glycosylase
ToN1_RS22385	COG0477	Major facilitator Superfamily
ToN1_RS22390	COG0583	DNA-binding transcription factor activity
ToN1_RS22400	COG1309	transcriptional regulator
ToN1_RS22405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ToN1_RS22415	COG1136	(ABC) transporter
ToN1_RS22415	COG0577	efflux transmembrane transporter activity
ToN1_RS22420	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ToN1_RS22430	COG2195	Cleaves the N-terminal amino acid of tripeptides
ToN1_RS22435	COG3530	Putative quorum-sensing-regulated virulence factor
ToN1_RS22440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ToN1_RS22440	COG2169	Transcriptional regulator
ToN1_RS22445	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ToN1_RS22450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ToN1_RS22455	COG1127	ABC transporter
ToN1_RS22470	COG1846	Transcriptional regulator
ToN1_RS22495	COG1620	l-lactate permease
ToN1_RS22505	COG1136	(ABC) transporter
ToN1_RS22530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ToN1_RS22540	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ToN1_RS22555	COG0446	pyridine nucleotide-disulphide oxidoreductase
ToN1_RS22555	COG1902	pentaerythritol trinitrate reductase activity
ToN1_RS22560	COG1196	nuclear chromosome segregation
ToN1_RS22560	COG0741	lytic transglycosylase activity
ToN1_RS22560	COG0739	heme binding
ToN1_RS22575	COG0671	phosphoesterase, PA-phosphatase related
ToN1_RS22585	COG0463	Glycosyl transferase, family 2
ToN1_RS22595	COG0671	phosphoesterase, PA-phosphatase related
ToN1_RS22600	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ToN1_RS22600	COG0047	phosphoribosylformylglycinamidine synthase activity
ToN1_RS22650	COG0504	CTP synthase activity
ToN1_RS22655	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ToN1_RS22660	COG0148	phosphopyruvate hydratase activity
ToN1_RS22665	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ToN1_RS22675	COG0791	NLP P60 protein
ToN1_RS22700	COG5654	RES domain protein
ToN1_RS22715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ToN1_RS22745	COG1942	4-Oxalocrotonate Tautomerase
ToN1_RS22750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ToN1_RS22755	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ToN1_RS22765	COG1024	Enoyl-CoA hydratase
ToN1_RS22770	COG0318	PFAM AMP-dependent synthetase and ligase
ToN1_RS22780	COG1846	Transcriptional regulator
ToN1_RS22790	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ToN1_RS22795	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS22815	COG1250	3-hydroxyacyl-CoA dehydrogenase
ToN1_RS22820	COG0183	Belongs to the thiolase family
ToN1_RS22845	COG1522	sequence-specific DNA binding
ToN1_RS22850	COG3108	Peptidase M15
ToN1_RS22855	COG2989	Protein conserved in bacteria
ToN1_RS22860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ToN1_RS22865	COG0842	Transport permease protein
ToN1_RS22865	COG1129	ABC transporter
ToN1_RS22870	COG0842	Transport permease protein
ToN1_RS22920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ToN1_RS22920	COG1042	CoA-binding domain protein
ToN1_RS22920	COG0045	succinate-CoA ligase (ADP-forming) activity
ToN1_RS22925	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ToN1_RS22935	COG1902	pentaerythritol trinitrate reductase activity
ToN1_RS22960	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS22975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ToN1_RS23000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ToN1_RS23025	COG0326	Molecular chaperone. Has ATPase activity
ToN1_RS23055	COG4251	negative regulation of phosphorylation
ToN1_RS23065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ToN1_RS23070	COG4660	Part of a membrane complex involved in electron transport
ToN1_RS23080	COG4658	electron transport chain
ToN1_RS23085	COG4656	Part of a membrane complex involved in electron transport
ToN1_RS23090	COG2878	Part of a membrane complex involved in electron transport
ToN1_RS23095	COG4657	Part of a membrane complex involved in electron transport
ToN1_RS23100	COG0167	dihydroorotate dehydrogenase activity
ToN1_RS23105	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ToN1_RS23110	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ToN1_RS23115	COG3842	ATPase activity
ToN1_RS23120	COG1178	ABC-type Fe3 transport system permease component
ToN1_RS23135	COG1840	ABC-type Fe3 transport system, periplasmic component
ToN1_RS23150	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ToN1_RS23160	COG0039	L-malate dehydrogenase activity
ToN1_RS23165	COG2188	Transcriptional regulator
ToN1_RS23180	COG1053	succinate dehydrogenase
ToN1_RS23185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ToN1_RS23190	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ToN1_RS23195	COG0372	Belongs to the citrate synthase family
ToN1_RS23200	COG0567	Dehydrogenase, E1 component
ToN1_RS23205	COG0508	dehydrogenase complex catalyzes the overall conversion of
ToN1_RS23210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ToN1_RS23215	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ToN1_RS23220	COG1199	ATP-dependent helicase activity
ToN1_RS23230	COG1763	Mo-molybdopterin cofactor biosynthetic process
ToN1_RS23235	COG0303	'Molybdopterin
ToN1_RS23240	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ToN1_RS23245	COG0314	molybdopterin synthase activity
ToN1_RS23255	COG0542	response to heat
ToN1_RS23275	COG0601	transmembrane transport
ToN1_RS23280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ToN1_RS23285	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ToN1_RS23290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ToN1_RS23300	COG2914	Belongs to the UPF0125 (RnfH) family
ToN1_RS23315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ToN1_RS23315	COG0519	Catalyzes the synthesis of GMP from XMP
ToN1_RS23320	COG1280	lysine exporter protein (LysE YggA)
ToN1_RS23325	COG1196	nuclear chromosome segregation
ToN1_RS23345	COG3047	cAMP biosynthetic process
ToN1_RS23385	COG3706	GGDEF domain
ToN1_RS23445	COG0776	regulation of translation
ToN1_RS23450	COG2944	sequence-specific DNA binding
ToN1_RS23480	COG4566	intracellular signal transduction
ToN1_RS23505	COG4566	intracellular signal transduction
ToN1_RS23515	COG5002	protein histidine kinase activity
ToN1_RS23530	COG2204	response regulator
ToN1_RS23535	COG1100	Small GTP-binding protein
ToN1_RS23540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ToN1_RS23540	COG4191	Histidine kinase
ToN1_RS23545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ToN1_RS23555	COG4251	negative regulation of phosphorylation
ToN1_RS23570	COG4566	intracellular signal transduction
ToN1_RS23580	COG5002	protein histidine kinase activity
ToN1_RS23580	COG0784	Response regulator, receiver
ToN1_RS23580	COG2205	protein histidine kinase activity
ToN1_RS23590	COG5002	protein histidine kinase activity
ToN1_RS23590	COG0784	Response regulator, receiver
ToN1_RS23590	COG2205	protein histidine kinase activity
ToN1_RS23610	COG0776	regulation of translation
ToN1_RS23630	COG2010	Cytochrome c
ToN1_RS23645	COG4372	Transposase
ToN1_RS23650	COG3436	PFAM IS66 Orf2 family protein
ToN1_RS23695	COG5002	protein histidine kinase activity
ToN1_RS23695	COG5001	Diguanylate cyclase
ToN1_RS23735	COG0326	Molecular chaperone. Has ATPase activity
ToN1_RS23770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ToN1_RS23775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ToN1_RS23780	COG0450	alkyl hydroperoxide reductase
ToN1_RS23805	COG2363	Small membrane protein
ToN1_RS23810	COG2814	Major facilitator Superfamily
ToN1_RS23820	COG0411	ABC transporter
ToN1_RS23845	COG1028	Short-chain dehydrogenase reductase Sdr
ToN1_RS23850	COG1024	Enoyl-CoA hydratase
ToN1_RS23915	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ToN1_RS23930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ToN1_RS23965	COG2133	pyrroloquinoline quinone binding
ToN1_RS24030	COG1966	Carbon starvation protein
ToN1_RS24035	COG2879	small protein
ToN1_RS24040	COG0523	cobalamin synthesis protein
ToN1_RS24050	COG0784	Response regulator, receiver
ToN1_RS24050	COG2205	protein histidine kinase activity
ToN1_RS24065	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ToN1_RS24070	COG0477	Major facilitator Superfamily
ToN1_RS24080	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ToN1_RS24100	COG1012	belongs to the aldehyde dehydrogenase family
ToN1_RS24105	COG1253	flavin adenine dinucleotide binding
ToN1_RS24115	COG4681	YaeQ
ToN1_RS24135	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ToN1_RS24145	COG0302	gtp cyclohydrolase
ToN1_RS24155	COG0306	phosphate transporter
ToN1_RS24165	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ToN1_RS24205	COG1115	amino acid carrier protein
ToN1_RS24210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_RS24285	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ToN1_RS24310	COG1760	l-serine dehydratase
ToN1_RS24315	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ToN1_RS24330	COG2271	Major facilitator Superfamily
ToN1_RS24335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ToN1_RS24340	COG0583	DNA-binding transcription factor activity
ToN1_RS24390	COG1757	Na H antiporter
ToN1_RS24395	COG2169	Transcriptional regulator
ToN1_RS24395	COG1917	Cupin 2, conserved barrel domain protein
ToN1_RS24415	COG0251	oxidation-reduction process
ToN1_RS24420	COG0477	Major facilitator Superfamily
ToN1_RS24430	COG1177	transmembrane transport
ToN1_RS24435	COG1176	ABC-type spermidine putrescine transport system, permease component I
ToN1_RS24445	COG3842	ATPase activity
ToN1_RS24480	COG1250	3-hydroxyacyl-CoA dehydrogenase
ToN1_RS24490	COG1802	Transcriptional regulator
ToN1_RS24495	COG0183	Belongs to the thiolase family
ToN1_RS24515	COG1960	acyl-CoA dehydrogenase activity
ToN1_RS24525	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ToN1_RS24525	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ToN1_RS24545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ToN1_RS24580	COG1024	Enoyl-CoA hydratase
ToN1_RS24605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ToN1_RS24620	COG0154	amidase activity