locus-tag class description HPK19_RS00010 ENOG4108FN7 Aldo keto reductase HPK19_RS00020 ENOG4105MDS 4-oxalocrotonate tautomerase HPK19_RS00025 ENOG4105EGI Transcriptional regulator HPK19_RS00055 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HPK19_RS00085 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HPK19_RS00105 ENOG4105CJ1 ABC, transporter HPK19_RS00115 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein HPK19_RS00140 ENOG4105M6F mutator MutT protein HPK19_RS00145 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HPK19_RS00150 ENOG4105BZU Histidine kinase HPK19_RS00155 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPK19_RS00190 ENOG4105M6F mutator MutT protein HPK19_RS00240 ENOG4105X3H Excalibur domain protein HPK19_RS00245 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS00260 ENOG4105X3H Excalibur domain protein HPK19_RS00265 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HPK19_RS00290 ENOG4105CJ1 ABC, transporter HPK19_RS00300 ENOG4105DRP amino acid AbC transporter HPK19_RS00305 ENOG4105EAD ABC transporter HPK19_RS00310 ENOG4105CT1 (ABC) transporter HPK19_RS00315 ENOG4105CDA abc transporter atp-binding protein HPK19_RS00330 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS00340 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HPK19_RS00415 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HPK19_RS00420 ENOG4105C5Y PTS System HPK19_RS00465 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HPK19_RS00475 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HPK19_RS00480 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HPK19_RS00485 ENOG4105ETE Transcriptional regulator (LacI family HPK19_RS00490 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HPK19_RS00495 ENOG4105DH8 myo-inositol catabolism HPK19_RS00500 ENOG4105D7K pfkb domain protein HPK19_RS00505 ENOG4105C26 Dehydrogenase HPK19_RS00510 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HPK19_RS00515 ENOG4105CS2 ec 3.2.1.21 HPK19_RS00520 ENOG4107HP6 Transcriptional regulator HPK19_RS00525 ENOG4105D7K pfkb domain protein HPK19_RS00530 ENOG4108UHU Aldolase HPK19_RS00535 ENOG4105CXK mandelate racemase muconate lactonizing HPK19_RS00540 ENOG4105DJB Major Facilitator Superfamily HPK19_RS00555 ENOG4108RVA ribokinase HPK19_RS00565 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HPK19_RS00595 ENOG4105ETE Transcriptional regulator (LacI family HPK19_RS00605 ENOG4105CJ1 ABC, transporter HPK19_RS00610 ENOG4108TU7 Inherit from COG: (ABC) transporter HPK19_RS00625 ENOG4108B31 Spore germination protein HPK19_RS00660 ENOG41069ER domain protein HPK19_RS00670 ENOG4108JB9 formate dehydrogenase HPK19_RS00680 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HPK19_RS00690 ENOG4105D06 uba thif-type nad fad binding protein HPK19_RS00695 ENOG4105CVM Molybdenum cofactor synthesis domain protein HPK19_RS00700 ENOG4108ZAF Molybdopterin HPK19_RS00705 ENOG41067WU Molybdopterin converting factor (Subunit 1) HPK19_RS00710 ENOG4105EPU Molybdenum cofactor synthesis domain protein HPK19_RS00715 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HPK19_RS00720 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HPK19_RS00725 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HPK19_RS00730 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HPK19_RS00735 ENOG4105E0C molybdate abc transporter HPK19_RS00760 ENOG4105F6J Alpha beta hydrolase fold HPK19_RS00785 ENOG4107T3P ABC, transporter HPK19_RS00795 ENOG4105DRS transport system, permease HPK19_RS00800 ENOG4105CG3 alpha amylase, catalytic region HPK19_RS00810 ENOG4105CKB glycosidase HPK19_RS00820 ENOG4105EVU fructokinase HPK19_RS00825 ENOG4105DG6 mannose-6-phosphate isomerase HPK19_RS00865 ENOG4105BZU Histidine kinase HPK19_RS00870 ENOG4105WH1 Two component transcriptional regulator luxr family HPK19_RS00875 ENOG4105C28 cystathionine HPK19_RS00890 ENOG4108WRK Transcriptional regulator HPK19_RS00915 ENOG4105D17 glycoside hydrolase, family 3 domain protein HPK19_RS00945 ENOG4105DEN Luciferase family HPK19_RS00950 ENOG4105YWU small acid-soluble spore protein HPK19_RS00955 ENOG41062ES Transcriptional regulator HPK19_RS00965 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HPK19_RS00970 ENOG4105BZJ Electron transfer flavoprotein HPK19_RS00975 ENOG4105C10 Electron transfer flavoprotein HPK19_RS01025 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HPK19_RS01035 ENOG4105KTH gatB Yqey HPK19_RS01040 ENOG41068P3 sporulation protein YqfC HPK19_RS01050 ENOG4105C9A Phoh family HPK19_RS01055 ENOG4105CTJ Metal Dependent Phosphohydrolase HPK19_RS01065 ENOG4107YR5 Diacylglycerol kinase HPK19_RS01070 ENOG4105KG3 cytidine deaminase HPK19_RS01075 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HPK19_RS01085 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) HPK19_RS01095 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HPK19_RS01100 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HPK19_RS01105 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPK19_RS01120 ENOG4105EGD dinuclear metal center protein, YbgI family HPK19_RS01125 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HPK19_RS01140 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HPK19_RS01165 ENOG4108JYZ YitT family HPK19_RS01170 ENOG4105FDK ABC transporter HPK19_RS01175 ENOG4105FAV ABC, transporter HPK19_RS01180 ENOG4105N80 Ferric uptake regulator, Fur family HPK19_RS01190 ENOG4108W6C Dehydrogenase HPK19_RS01215 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HPK19_RS01220 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HPK19_RS01225 ENOG4108I5D sulfate abc transporter HPK19_RS01230 ENOG4105ECW sulfate abc transporter HPK19_RS01240 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HPK19_RS01270 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPK19_RS01285 ENOG4107RF6 penicillin-binding protein HPK19_RS01300 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HPK19_RS01305 ENOG4105WDJ 50S ribosomal protein L33 HPK19_RS01310 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HPK19_RS01320 ENOG4108VXD carboxy-peptidase HPK19_RS01330 ENOG4105DKQ ROK family HPK19_RS01335 ENOG4105E0M Sulfatase HPK19_RS01350 ENOG4105C5X domain protein HPK19_RS01375 ENOG4106855 Competence protein HPK19_RS01400 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HPK19_RS01415 ENOG4105C0D helicase HPK19_RS01420 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HPK19_RS01425 ENOG4108JEM The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HPK19_RS01445 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPK19_RS01450 ENOG4105US7 Histidine kinase HPK19_RS01455 ENOG4105CFH Aspartokinase HPK19_RS01460 ENOG4108ZB6 transcriptional regulator AsnC family HPK19_RS01465 ENOG4105CHM Aminotransferase HPK19_RS01470 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HPK19_RS01475 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HPK19_RS01485 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HPK19_RS01490 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) HPK19_RS01495 ENOG4107RIQ Sulfate adenylate transferase HPK19_RS01500 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HPK19_RS01515 ENOG4107WA4 MmpL domain-containing protein HPK19_RS01520 ENOG4107ZE5 PPIases accelerate the folding of proteins HPK19_RS01525 ENOG4105WZW rhodanese family HPK19_RS01530 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HPK19_RS01550 ENOG4105CBJ Metal-dependent enzyme HPK19_RS01560 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HPK19_RS01565 ENOG4105DC7 peptidase M24 HPK19_RS01570 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HPK19_RS01585 ENOG4105CD2 stage iii sporulation protein aa HPK19_RS01590 ENOG4105KR5 Stage iii sporulation protein HPK19_RS01600 ENOG4105KQ4 Stage iii sporulation protein ad HPK19_RS01610 ENOG410644B Stage III sporulation protein af HPK19_RS01630 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HPK19_RS01635 ENOG4108ZSR alkaline shock protein HPK19_RS01645 ENOG4105M7K Involved in the transcription termination process (By similarity) HPK19_RS01650 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HPK19_RS01655 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HPK19_RS01660 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HPK19_RS01670 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HPK19_RS01675 ENOG4105DX0 Hemolysin A HPK19_RS01685 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HPK19_RS01690 ENOG4105S1Z Stage IV sporulation protein B HPK19_RS01695 ENOG4107QQR Sporulation HPK19_RS01710 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HPK19_RS01720 ENOG4108JUB Transcriptional regulator HPK19_RS01730 ENOG4107RDP Dehydrogenase HPK19_RS01735 ENOG4105CKM Branched-chain carboxylic acid kinase HPK19_RS01750 ENOG4105CPP Dehydrogenase, E1 component HPK19_RS01755 ENOG4105C7S Dehydrogenase HPK19_RS01765 ENOG4105E5W Transporter HPK19_RS01780 ENOG4108Y6J UPF0403 protein HPK19_RS01790 ENOG4108HW3 (ABC) transporter HPK19_RS01795 ENOG4108JPW Aminotransferase HPK19_RS01800 ENOG4105E5Q amino acid AbC transporter HPK19_RS01805 ENOG4105CDA abc transporter atp-binding protein HPK19_RS01810 ENOG4108S4H thioesterase Superfamily protein HPK19_RS01815 ENOG4108QEG Membrane HPK19_RS01820 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HPK19_RS01830 ENOG4108ZVT methylmalonyl-coA epimerase HPK19_RS01835 ENOG4108HNZ carboxyl transferase HPK19_RS01840 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HPK19_RS01845 ENOG4107ZTW SNARE associated Golgi HPK19_RS01865 ENOG4105KIR Thiol-disulfide oxidoreductase dcc HPK19_RS01870 ENOG4108Z18 K06886 hemoglobin HPK19_RS01890 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HPK19_RS01895 ENOG4105CAH Chromate HPK19_RS01900 ENOG4105FGV Chromate HPK19_RS01915 ENOG4107TXC Transcriptional regulator HPK19_RS01920 ENOG4105C3M thioredoxin reductase HPK19_RS01925 ENOG4108UZ3 Transporter HPK19_RS01930 ENOG41086D8 Transcriptional regulator HPK19_RS01935 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HPK19_RS01945 ENOG4107ZXU DSBA oxidoreductase HPK19_RS01955 ENOG4105DIH basic membrane HPK19_RS01960 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HPK19_RS01995 ENOG4105II7 pyrroline-5-carboxylate reductase HPK19_RS02000 ENOG41069FQ Metallo-beta-lactamase superfamily HPK19_RS02005 ENOG4108IXY short-chain dehydrogenase reductase HPK19_RS02015 ENOG4105NAE bifunctional deaminase-reductase domain protein HPK19_RS02035 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPK19_RS02050 ENOG4107S4Y M20 DapE family protein YgeY HPK19_RS02055 ENOG4108WHG pyridoxamine 5'-phosphate HPK19_RS02085 ENOG4105DTQ mandelate racemase muconate lactonizing HPK19_RS02090 ENOG4105FQP Beta-lactamase HPK19_RS02095 ENOG4105DEF Extracellular solute-binding protein, family 5 HPK19_RS02105 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPK19_RS02110 ENOG4105C3U ABC transporter HPK19_RS02115 ENOG4108JQ7 (ABC) transporter HPK19_RS02120 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HPK19_RS02130 ENOG410905X membrane-flanked domain protein HPK19_RS02135 ENOG4105CKV Membrane HPK19_RS02140 ENOG4105IQ5 FAD linked oxidase domain protein HPK19_RS02160 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HPK19_RS02170 ENOG4108TVJ Nitroreductase HPK19_RS02175 ENOG4105CZ9 Domain of unknown function (DU1801) HPK19_RS02185 ENOG4105DWF phosphomethylpyrimidine kinase HPK19_RS02190 ENOG4108IQI permease HPK19_RS02200 ENOG4108W8B Beta-lactamase domain protein HPK19_RS02215 ENOG4105CIS alcohol dehydrogenase HPK19_RS02220 ENOG4105WH1 Two component transcriptional regulator luxr family HPK19_RS02230 ENOG4105CJ1 ABC, transporter HPK19_RS02235 ENOG4107QWP ABC-2 type transporter HPK19_RS02260 ENOG41075H3 AraC family transcriptional regulator HPK19_RS02270 ENOG4108TN2 lmbE family HPK19_RS02290 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HPK19_RS02310 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HPK19_RS02330 ENOG410667J hydrolase HPK19_RS02365 ENOG4107QW4 alcohol dehydrogenase HPK19_RS02390 ENOG4105EFA 4-hydroxyphenylacetate HPK19_RS02410 ENOG4105KME endoribonuclease L-psp HPK19_RS02455 ENOG4105RHY Pfam:UPF0157 HPK19_RS02460 ENOG4105CPC Aldo Keto reductase HPK19_RS02485 ENOG4105MZ9 stage II sporulation protein m HPK19_RS02490 ENOG4105I3K Ferric uptake regulator, Fur family HPK19_RS02500 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPK19_RS02505 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HPK19_RS02510 ENOG4108ZCF integral membrane protein HPK19_RS02520 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HPK19_RS02545 ENOG4105DVE abc transporter atp-binding protein HPK19_RS02550 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HPK19_RS02555 ENOG4105DZ1 carboxypeptidase HPK19_RS02560 ENOG41082AN stage II sporulation protein HPK19_RS02565 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HPK19_RS02570 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPK19_RS02585 ENOG41090VF Stage v sporulation protein ac HPK19_RS02590 ENOG4105CZ3 stage V sporulation protein ad HPK19_RS02600 ENOG4105G6R Stage v sporulation protein ae HPK19_RS02610 ENOG4105PTM secreted protein HPK19_RS02615 ENOG4107ZE5 PPIases accelerate the folding of proteins HPK19_RS02640 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HPK19_RS02645 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HPK19_RS02660 ENOG4108QEG Membrane HPK19_RS02665 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPK19_RS02670 ENOG4105DZ1 carboxypeptidase HPK19_RS02675 ENOG4108JIC nucleoside recognition domain protein HPK19_RS02690 ENOG4105C28 cystathionine HPK19_RS02695 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) HPK19_RS02715 ENOG4105FE9 pseudouridine synthase HPK19_RS02725 ENOG4107TWT Cytochrome c biogenesis protein HPK19_RS02730 ENOG4105CRE cytochrome C HPK19_RS02735 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPK19_RS02740 ENOG4105BZU Histidine kinase HPK19_RS02745 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HPK19_RS02750 ENOG4105EHG Permease protein HPK19_RS02755 ENOG4105E0A ABC, transporter HPK19_RS02760 ENOG4108WBT adenosyltransferase HPK19_RS02770 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) HPK19_RS02775 ENOG4108SAX Membrane HPK19_RS02790 ENOG4105C9U ATP-dependent DNA helicase RecQ HPK19_RS02815 ENOG4107X2D transcriptional regulator, merr family HPK19_RS02820 ENOG4108S6Z Negative regulator of genetic competence HPK19_RS02830 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HPK19_RS02835 ENOG4105HDK L-asparaginase HPK19_RS02845 ENOG4105CAT Cytidine monophosphate kinase HPK19_RS02865 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HPK19_RS02870 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HPK19_RS02890 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HPK19_RS02895 ENOG4105K70 DNA-binding protein HPK19_RS02900 ENOG4105EUJ GTP cyclohydrolase i HPK19_RS02905 ENOG4105XXQ heptaprenyl diphosphate synthase component I HPK19_RS02910 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HPK19_RS02915 ENOG4105EAH synthase HPK19_RS02920 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HPK19_RS02930 ENOG4105D49 3-dehydroquinate synthase HPK19_RS02935 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HPK19_RS02940 ENOG41068YB TPR repeat-containing protein HPK19_RS02955 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) HPK19_RS02960 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HPK19_RS02965 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit HPK19_RS02985 ENOG4108JYZ YitT family HPK19_RS02990 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HPK19_RS03000 ENOG4105FJR Lmbe family HPK19_RS03005 ENOG4105CPK Glycosyl transferase (Group 1 HPK19_RS03015 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HPK19_RS03020 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HPK19_RS03025 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HPK19_RS03035 ENOG4105DVT helicase HPK19_RS03040 ENOG4105YAC HPK19_RS03060 ENOG4105CSM endonuclease III HPK19_RS03070 ENOG4105BZ4 penicillin-binding protein HPK19_RS03120 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HPK19_RS03125 ENOG4105VTR Integrase HPK19_RS03210 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HPK19_RS03355 ENOG4105CNU cell division protein FtsK HPK19_RS03385 ENOG4107NTZ HPK19_RS03400 ENOG4105EP9 oxidoreductase HPK19_RS03405 ENOG4105DVT helicase HPK19_RS03440 ENOG4105CTD carboxy-peptidase HPK19_RS03460 ENOG41082BM Transcriptional regulator, arsr family HPK19_RS03465 ENOG4105CTD carboxy-peptidase HPK19_RS03470 ENOG41065KQ synthase HPK19_RS03480 ENOG410890F Dynamin family HPK19_RS03485 ENOG4105KHC sulfurtransferase HPK19_RS03500 ENOG41081VK Ribonuclease HPK19_RS03545 ENOG4108K88 Membrane HPK19_RS03555 ENOG4105DSE periplasmic solute binding protein HPK19_RS03560 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HPK19_RS03570 ENOG4108J59 Extracellular solute-binding protein, family 5 HPK19_RS03575 ENOG4107T5V SNARE associated Golgi HPK19_RS03590 ENOG4108PJD permease HPK19_RS03605 ENOG4108ZRV stage ii sporulation protein p HPK19_RS03640 ENOG4105BZ1 (ABC) transporter HPK19_RS03660 ENOG4108V06 Glutathione peroxidase HPK19_RS03670 ENOG4105C5H ABC transporter HPK19_RS03685 ENOG4108Y6J UPF0403 protein HPK19_RS03690 ENOG4107YX5 Pfam:DUF548 HPK19_RS03705 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HPK19_RS03710 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HPK19_RS03720 ENOG4108UT2 hemolysin iii HPK19_RS03725 ENOG4105DYB Isoaspartyl dipeptidase HPK19_RS03730 ENOG4105DIH basic membrane HPK19_RS03735 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HPK19_RS03740 ENOG4108RCR degv family HPK19_RS03750 ENOG4108KF3 Electron transport protein SCO1 SenC HPK19_RS03760 ENOG4108Z7F N-acetyltransferase HPK19_RS03790 ENOG4105C37 (CBS) domain HPK19_RS03800 ENOG4105BZU Histidine kinase HPK19_RS03835 ENOG4108X4Q Hydrolase HPK19_RS03840 ENOG4105CPN adenine deaminase HPK19_RS03845 ENOG4105IJJ transcriptional regulator, crp fnr family HPK19_RS03850 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HPK19_RS03870 ENOG4105E1K spore germination protein HPK19_RS03895 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HPK19_RS03905 ENOG4108RCF TRANSCRIPTIONal HPK19_RS03915 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HPK19_RS03965 ENOG4107XGZ Hydrolase HPK19_RS03970 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HPK19_RS03975 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HPK19_RS04000 ENOG4108R0M Aminoglycoside HPK19_RS04030 ENOG4105YGK Pfam:UPF0157 HPK19_RS04070 ENOG4105ENY Ethanolamine utilization protein eutH HPK19_RS04080 ENOG4105EKQ RNA-directed DNA polymerase HPK19_RS04095 ENOG4105KIR Thiol-disulfide oxidoreductase dcc HPK19_RS04100 ENOG4105VRR gCN5-related N-acetyltransferase HPK19_RS04135 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HPK19_RS04150 ENOG4105DQ6 Transposase HPK19_RS04170 ENOG4105KAF membrAne HPK19_RS04175 ENOG4105VMP Transcriptional regulator HPK19_RS04215 ENOG4105UBK short-chain dehydrogenase reductase HPK19_RS04260 ENOG4105EKQ RNA-directed DNA polymerase HPK19_RS04295 ENOG4105EKQ RNA-directed DNA polymerase HPK19_RS04300 ENOG4107YB1 Trehalose corynomycolyl transferase HPK19_RS04305 ENOG4107Y9E nuclease HPK19_RS04315 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS04340 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HPK19_RS04390 ENOG4105SZ6 Thioredoxin HPK19_RS04395 ENOG4107RFY SbcCD D subunit HPK19_RS04405 ENOG4107R0W ABC transporter HPK19_RS04410 ENOG4105E5Q amino acid AbC transporter HPK19_RS04420 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HPK19_RS04430 ENOG4105YA8 Transcriptional regulator HPK19_RS04460 ENOG41067MG lrgb family HPK19_RS04475 ENOG4105CGK Exodeoxyribonuclease III HPK19_RS04505 ENOG4105DK7 lysyl-tRNA synthetase HPK19_RS04515 ENOG4105EPR degv family HPK19_RS04520 ENOG4105XZV Protein of unknown function (DUF3243) HPK19_RS04525 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPK19_RS04555 ENOG4108K4B hydrolase HPK19_RS04570 ENOG4105EYF MMPL domain protein HPK19_RS04580 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPK19_RS04730 ENOG4105DVE abc transporter atp-binding protein HPK19_RS04750 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPK19_RS04755 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS04760 ENOG41069H0 dihydroorotase EC 3.5.2.3 HPK19_RS04785 ENOG4105C6Z Gluconate HPK19_RS04805 ENOG4105BZU Histidine kinase HPK19_RS04815 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HPK19_RS04820 ENOG4105BZU Histidine kinase HPK19_RS04825 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPK19_RS04835 ENOG4105ECK Fatty Acid Desaturase HPK19_RS04840 ENOG4108ZGX Histidine kinase HPK19_RS04845 ENOG4108S01 response regulator HPK19_RS04850 ENOG4107YUH hydrolase HPK19_RS04865 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family HPK19_RS04880 ENOG4105CVJ phosphoglycerate mutase HPK19_RS04935 ENOG4106DF1 HPK19_RS04940 ENOG4105E98 transcriptional regulator DeoR family HPK19_RS04945 ENOG4105DE4 1-phosphofructokinase HPK19_RS04950 ENOG4105DM4 PTS System HPK19_RS04955 ENOG4105E1K spore germination protein HPK19_RS04960 ENOG4108Q8B Spore germination protein HPK19_RS04965 ENOG4108Q5U germination protein, ger(x)c family HPK19_RS04970 ENOG4108UT2 hemolysin iii HPK19_RS04980 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPK19_RS05000 ENOG4106BRA Membrane HPK19_RS05005 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HPK19_RS05025 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HPK19_RS05045 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HPK19_RS05085 ENOG4108DBC nitroreductase HPK19_RS05090 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HPK19_RS05100 ENOG4105DQ6 Transposase HPK19_RS05110 ENOG41090MY MarR family Transcriptional regulator HPK19_RS05115 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HPK19_RS05125 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HPK19_RS05130 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HPK19_RS05140 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HPK19_RS05145 ENOG4105DEU major facilitator superfamily HPK19_RS05150 ENOG4105CEY Amp-dependent synthetase and ligase HPK19_RS05180 ENOG4105XTG Pfam:DUF156 HPK19_RS05190 ENOG41085GJ domain protein HPK19_RS05215 ENOG4105D5P Methylmalonyl-coA mutase HPK19_RS05220 ENOG4105DJT lAO AO transport system ATPase HPK19_RS05225 ENOG4108ZVT methylmalonyl-coA epimerase HPK19_RS05230 ENOG4108HNZ carboxyl transferase HPK19_RS05235 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HPK19_RS05245 ENOG4105DUM transcriptional regulator, lysR family HPK19_RS05265 ENOG4107S2E monooxygenase HPK19_RS05270 ENOG4107Y80 Major Facilitator superfamily HPK19_RS05280 ENOG4108IFG nitrite reductase, (NAD(P)H) HPK19_RS05285 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HPK19_RS05290 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HPK19_RS05295 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HPK19_RS05300 ENOG4107V9H nitrite transporter HPK19_RS05305 ENOG4107RQ2 Cytochrome c oxidase, subunit I HPK19_RS05310 ENOG4105NAA Cytochrome C oxidase, subunit II HPK19_RS05335 ENOG4107SUZ Sodium/hydrogen exchanger family HPK19_RS05360 ENOG4105E98 transcriptional regulator DeoR family HPK19_RS05365 ENOG4105D9R oxidoreductase HPK19_RS05370 ENOG41090KN UPF0303 protein HPK19_RS05385 ENOG4107QJZ Glycosyl transferase, family 2 HPK19_RS05390 ENOG4105D9N nucleoside HPK19_RS05415 ENOG4105XRQ Xanthine dehydrogenase accessory factor HPK19_RS05425 ENOG4105BZU Histidine kinase HPK19_RS05435 ENOG4105BZ4 penicillin-binding protein HPK19_RS05450 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) HPK19_RS05480 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS05485 ENOG4105CF7 AraC family transcriptional regulator HPK19_RS05490 ENOG410667J hydrolase HPK19_RS05495 ENOG4105S8Q sugar efflux transporter HPK19_RS05500 ENOG4105VEQ Cold shock protein HPK19_RS05510 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPK19_RS05535 ENOG4107U9B transcriptional regulator HPK19_RS05540 ENOG4108UMN azlc family HPK19_RS05545 ENOG4105KMT branched-chain amino acid HPK19_RS05555 ENOG4105E1K spore germination protein HPK19_RS05570 ENOG4105EEM helicase HPK19_RS05575 ENOG4105CJ1 ABC, transporter HPK19_RS05585 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HPK19_RS05600 ENOG4108QTI )-transporter HPK19_RS05605 ENOG4105D9U N-acetyltransferase HPK19_RS05610 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HPK19_RS05635 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPK19_RS05660 ENOG4105C5E polysaccharide biosynthesis protein HPK19_RS05665 ENOG4105C1B dTDP-glucose 4-6-dehydratase HPK19_RS05670 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HPK19_RS05675 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HPK19_RS05700 ENOG41090MY MarR family Transcriptional regulator HPK19_RS05705 ENOG4108VGI doxx family HPK19_RS05710 ENOG4108VGI doxx family HPK19_RS05715 ENOG4105C9Q fumarate hydratase class II HPK19_RS05720 ENOG4105DKQ ROK family HPK19_RS05725 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HPK19_RS05730 ENOG4106UW1 Major Facilitator superfamily HPK19_RS05735 ENOG4105D17 glycoside hydrolase, family 3 domain protein HPK19_RS05750 ENOG41082YX Transcriptional regulator, arsr family HPK19_RS05755 ENOG4105D6J arsenicaL-resistance protein HPK19_RS05770 ENOG4107U9B transcriptional regulator HPK19_RS05775 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPK19_RS05785 ENOG4105FS7 Transcriptional regulator HPK19_RS05790 ENOG4108TVJ Nitroreductase HPK19_RS05815 ENOG4108MUZ hydrolase HPK19_RS05855 ENOG4105MSI germination protein ypeb HPK19_RS05905 ENOG4105EFI regulatoR HPK19_RS05910 ENOG4105C9B Cysteine desulfurase HPK19_RS05915 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HPK19_RS05945 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HPK19_RS05955 ENOG4108R1P HPK19_RS05970 ENOG4106611 bacteriocin immunity HPK19_RS05975 ENOG4105C1J atp-dependent rna helicase HPK19_RS05985 ENOG4107ZYJ bioY protein HPK19_RS05990 ENOG4107F3J Amp-dependent synthetase and ligase HPK19_RS06010 ENOG4105N14 lysine exporter protein LysE YggA HPK19_RS06105 ENOG4105CHF Glutathione S-transferase HPK19_RS06110 ENOG4108MJ3 acetyltransferase HPK19_RS06150 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HPK19_RS06165 ENOG4108YYS metal-dependent hydrolase (By similarity) HPK19_RS06170 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase HPK19_RS06180 ENOG4105EMU Dehydrogenase HPK19_RS06190 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HPK19_RS06205 ENOG4105CA9 Pyruvate kinase HPK19_RS06215 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS06230 ENOG41061GT Aldolase HPK19_RS06250 ENOG41083I7 UPF0145 protein HPK19_RS06265 ENOG4108QBV Monogalactosyldiacylglycerol synthase HPK19_RS06275 ENOG4105DQR SNARE associated Golgi HPK19_RS06280 ENOG4105US7 Histidine kinase HPK19_RS06285 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPK19_RS06290 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HPK19_RS06295 ENOG41066YJ Beta-lactamase HPK19_RS06300 ENOG4105EN6 Membrane HPK19_RS06320 ENOG4105F32 YngK protein HPK19_RS06325 ENOG4105C9U ATP-dependent DNA helicase RecQ HPK19_RS06330 ENOG4107XJU UPF0178 protein HPK19_RS06335 ENOG4105FE9 pseudouridine synthase HPK19_RS06340 ENOG4107SNB ankyrin repeat protein YahD HPK19_RS06345 ENOG4107R7A Allophanate hydrolase subunit 2 HPK19_RS06350 ENOG4105E7W lamb ycsf family protein HPK19_RS06355 ENOG4105P4J Allophanate hydrolase, subunit 1 HPK19_RS06360 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HPK19_RS06385 ENOG4107KJX Transcriptional regulator HPK19_RS06410 ENOG4108KGH TRANSCRIPTIONal HPK19_RS06415 ENOG4107T40 Inherit from COG: Glycosyltransferase 36 HPK19_RS06420 ENOG4107T40 Inherit from COG: Glycosyltransferase 36 HPK19_RS06430 ENOG410823G oxidoreductase HPK19_RS06435 ENOG4107QP6 Xylose isomerase domain protein TIM barrel HPK19_RS06455 ENOG41063ZK Transcriptional Regulator AraC Family HPK19_RS06520 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HPK19_RS06540 ENOG4105DPN Oligoendopeptidase f HPK19_RS06545 ENOG4105E5D amino acid HPK19_RS06555 ENOG4105BZ1 (ABC) transporter HPK19_RS06560 ENOG4105BZ1 (ABC) transporter HPK19_RS06570 ENOG41069ER domain protein HPK19_RS06590 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HPK19_RS06595 ENOG4105D6E homoserine dehydrogenase HPK19_RS06605 ENOG4105C3R Methionine synthase HPK19_RS06615 ENOG4105EWU Squalene--hopene cyclase HPK19_RS06650 ENOG4105NAE bifunctional deaminase-reductase domain protein HPK19_RS06660 ENOG4108903 Formimidoylglutamase HPK19_RS06665 ENOG4105CI2 imidazolone-5-propionate hydrolase HPK19_RS06680 ENOG4105U7G Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity) HPK19_RS06700 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HPK19_RS06705 ENOG4105MPN Membrane HPK19_RS06715 ENOG4107SNB ankyrin repeat protein YahD HPK19_RS06730 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HPK19_RS06735 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPK19_RS06750 ENOG4105CEY Amp-dependent synthetase and ligase HPK19_RS06780 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HPK19_RS06785 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HPK19_RS06795 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HPK19_RS06805 ENOG4105CHU acetyl-coa acetyltransferase HPK19_RS06810 ENOG4105C1G acyl-Coa dehydrogenase HPK19_RS06815 ENOG4105CB2 alcohol dehydrogenase HPK19_RS06825 ENOG4105EPR degv family HPK19_RS06830 ENOG4108NGU Transcriptional regulator HPK19_RS06870 ENOG4108ZP8 Acetolactate synthase small subunit HPK19_RS06875 ENOG4105C7K acetolactate synthase HPK19_RS06880 ENOG4105C01 Dihydroxy-acid dehydratase HPK19_RS06885 ENOG4105CM2 brancheD-chain amino acid aminotransferase HPK19_RS06895 ENOG4105E90 ABC transporter HPK19_RS06905 ENOG4105DMF Dehydrogenase HPK19_RS06915 ENOG4107Y2X deaminase HPK19_RS06925 ENOG4105C5H ABC transporter HPK19_RS06935 ENOG41082BM Transcriptional regulator, arsr family HPK19_RS06940 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HPK19_RS06960 ENOG4108Z66 YbaK ebsC protein HPK19_RS06965 ENOG4105FR1 rard protein HPK19_RS06975 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HPK19_RS06985 ENOG4107SJW iron permease, FTR1 HPK19_RS06990 ENOG4105DBE peroxidase HPK19_RS06995 ENOG410650H (LipO)protein HPK19_RS07015 ENOG4105DUM transcriptional regulator, lysR family HPK19_RS07020 ENOG4108Z7F N-acetyltransferase HPK19_RS07035 ENOG4105BZ1 (ABC) transporter HPK19_RS07075 ENOG4108JPW Aminotransferase HPK19_RS07080 ENOG4105C0D helicase HPK19_RS07085 ENOG4105WH1 Two component transcriptional regulator luxr family HPK19_RS07090 ENOG4105ENE Histidine kinase HPK19_RS07105 ENOG4105DUX Transporter HPK19_RS07110 ENOG4107Z0P This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HPK19_RS07115 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HPK19_RS07145 ENOG4105CHR reductase HPK19_RS07150 ENOG4105C1G acyl-Coa dehydrogenase HPK19_RS07155 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HPK19_RS07175 ENOG41067SE Tetr family transcriptional regulator HPK19_RS07180 ENOG4105CEY Amp-dependent synthetase and ligase HPK19_RS07190 ENOG4105C1G acyl-Coa dehydrogenase HPK19_RS07205 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPK19_RS07210 ENOG4107YBY Hydrolase HPK19_RS07215 ENOG41068WN HPK19_RS07220 ENOG4106A3M Cytochrome p-450 HPK19_RS07230 ENOG4105D7N magnesium and cobalt transport protein CorA HPK19_RS07265 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HPK19_RS07275 ENOG4108IV0 ABC, transporter HPK19_RS07280 ENOG4105C0Z ABC transporter HPK19_RS07285 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPK19_RS07290 ENOG4105C32 Amino acid ABC transporter (Permease) HPK19_RS07305 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPK19_RS07310 ENOG4105K4P CoA-binding domain protein HPK19_RS07315 ENOG4105C0H protease HPK19_RS07320 ENOG4105BZU Histidine kinase HPK19_RS07325 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPK19_RS07330 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HPK19_RS07355 ENOG41067CD Small, acid-soluble spore protein Tlp HPK19_RS07370 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPK19_RS07375 ENOG4108I0Z Aconitate hydratase HPK19_RS07435 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HPK19_RS07460 ENOG4108FKH Transglycosylase SLT domain HPK19_RS07525 ENOG4105CAR Terminase, large subunit HPK19_RS07555 ENOG4107QTH restriction modification system DNA specificity domain HPK19_RS07570 ENOG4105VMP Transcriptional regulator HPK19_RS07610 ENOG4108ZUE Phage regulatory protein rha HPK19_RS07630 ENOG4108IMY Transcriptional regulator HPK19_RS07640 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) HPK19_RS07665 ENOG4105ED1 spovr family HPK19_RS07675 ENOG4108VJ1 Transcriptional regulator (CarD family HPK19_RS07680 ENOG4105VEQ Cold shock protein HPK19_RS07725 ENOG4107QIV Cytochrome c biogenesis protein HPK19_RS07730 ENOG4108UMN azlc family HPK19_RS07745 ENOG4105BZ1 (ABC) transporter HPK19_RS07750 ENOG4105BZ1 (ABC) transporter HPK19_RS07760 ENOG4105VXM UPF0154 protein HPK19_RS07770 ENOG4105CV1 Transketolase (EC 2.2.1.1) HPK19_RS07775 ENOG4105VPS UPF0291 protein HPK19_RS07780 ENOG4108SVB resolvase HPK19_RS07810 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein HPK19_RS07820 ENOG4105EB3 Histidine kinase HPK19_RS07860 ENOG4105CHH sulfate transporter HPK19_RS07875 ENOG41085PJ rdd domain containing protein HPK19_RS07880 ENOG4105PXI polysaccharide deacetylase HPK19_RS07885 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HPK19_RS07910 ENOG4108ZMX Domain of unknown function (DU1801) HPK19_RS07935 ENOG4105NAE bifunctional deaminase-reductase domain protein HPK19_RS07950 ENOG4105EWM Histidine kinase HPK19_RS07960 ENOG4105C19 ABC transporter HPK19_RS07970 ENOG4105G6Z alkaline phosphatase HPK19_RS08015 ENOG4105DU6 RNA polymerase HPK19_RS08065 ENOG4105VRR gCN5-related N-acetyltransferase HPK19_RS08085 ENOG4105CMG Carbohydrate kinase HPK19_RS08105 ENOG4105DME alpha-galactosidase HPK19_RS08135 ENOG4107TH2 purine nucleoside phosphorylase HPK19_RS08150 ENOG4105C5F glutamine synthetase HPK19_RS08155 ENOG4105C5F glutamine synthetase HPK19_RS08160 ENOG4105KV4 Transcriptional regulator HPK19_RS08165 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HPK19_RS08170 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HPK19_RS08175 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HPK19_RS08185 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate HPK19_RS08195 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HPK19_RS08200 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HPK19_RS08205 ENOG4105H67 Protein of unknown function (DUF421) HPK19_RS08210 ENOG4107SC7 Inner membrane transporter yjeM HPK19_RS08235 ENOG4105XEA Tetr family transcriptional regulator HPK19_RS08240 ENOG4107Y80 Major Facilitator superfamily HPK19_RS08250 ENOG4105JD4 ATPase yjob HPK19_RS08255 ENOG41073R8 VanW family HPK19_RS08270 ENOG4105C87 Aminotransferase class I and II HPK19_RS08285 ENOG4105JSC dimethylmenaquinone methyltransferase HPK19_RS08290 ENOG4105EA8 2-Nitropropane dioxygenase HPK19_RS08325 ENOG4105VEQ Cold shock protein HPK19_RS08400 ENOG4105CS2 ec 3.2.1.21 HPK19_RS08410 ENOG4105D0M Protease HtpX homolog HPK19_RS08415 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein HPK19_RS08445 ENOG41087PP glycosyltransferase MGT family HPK19_RS08480 ENOG41082F9 transcriptional regulator HPK19_RS08490 ENOG4105NX3 Membrane HPK19_RS08495 ENOG4105VMP Transcriptional regulator HPK19_RS08530 ENOG4105DXI Major Facilitator superfamily HPK19_RS08540 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HPK19_RS08545 ENOG4105CXI aluminum resistance protein HPK19_RS08550 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HPK19_RS08565 ENOG4105D7N magnesium and cobalt transport protein CorA HPK19_RS08570 ENOG4106F1P AAA ATPase, central domain protein HPK19_RS08595 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HPK19_RS08620 ENOG4105DXB Major Facilitator superfamily HPK19_RS08625 ENOG4107R7I amino acid HPK19_RS08640 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HPK19_RS08645 ENOG4108RWP Major Facilitator Superfamily protein HPK19_RS08650 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HPK19_RS08660 ENOG4105C7B Threonine dehydratase HPK19_RS08675 ENOG4105DQ6 Transposase HPK19_RS08710 ENOG4105CV8 reductase HPK19_RS08715 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HPK19_RS08735 ENOG4105E0S extracellular solute-binding protein family 1 HPK19_RS08740 ENOG4105FKQ transcriptional regulator HPK19_RS08750 ENOG4105C8I hydrolase, family 38 HPK19_RS08760 ENOG4105DM4 PTS System HPK19_RS08770 ENOG4105DH8 myo-inositol catabolism HPK19_RS08775 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HPK19_RS08780 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HPK19_RS08795 ENOG4105CK5 oxidoreductase HPK19_RS08800 ENOG4105ETE Transcriptional regulator (LacI family HPK19_RS08815 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HPK19_RS08830 ENOG4108UW5 maltose o-acetyltransferase HPK19_RS08835 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HPK19_RS08850 ENOG4105C28 cystathionine HPK19_RS08855 ENOG4105C28 cystathionine HPK19_RS08860 ENOG4105DVT helicase HPK19_RS08870 ENOG4105BZ1 (ABC) transporter HPK19_RS08875 ENOG4105BZ1 (ABC) transporter HPK19_RS08880 ENOG4105CG3 alpha amylase, catalytic region HPK19_RS08885 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HPK19_RS08890 ENOG4105DER m42 family HPK19_RS08900 ENOG4107RA9 decarboxylase HPK19_RS08925 ENOG4105C26 Dehydrogenase HPK19_RS08930 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HPK19_RS08935 ENOG4105C5H ABC transporter HPK19_RS08940 ENOG4108S4H thioesterase Superfamily protein HPK19_RS09010 ENOG4105C0H protease HPK19_RS09045 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HPK19_RS09080 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HPK19_RS09090 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HPK19_RS09095 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HPK19_RS09105 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HPK19_RS09115 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) HPK19_RS09150 ENOG4108DMH HTH_ARAC HPK19_RS09160 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HPK19_RS09165 ENOG4105CIH Imidazole acetol-phosphate transaminase HPK19_RS09170 ENOG4105F1J Homogentisate 1,2-dioxygenase HPK19_RS09175 ENOG4105ERH Fumarylacetoacetate hydrolase HPK19_RS09180 ENOG4107XWI flavin reductase domain protein, FMN-binding HPK19_RS09185 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HPK19_RS09190 ENOG4105KVH Transcriptional regulator HPK19_RS09195 ENOG4108WS4 fmn reductase HPK19_RS09200 ENOG4107QW4 alcohol dehydrogenase HPK19_RS09205 ENOG4105DD7 kinase (PfkB family HPK19_RS09215 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HPK19_RS09220 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HPK19_RS09240 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HPK19_RS09255 ENOG4105DQU oxidoreductase, subunit beta HPK19_RS09260 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HPK19_RS09265 ENOG4108IGT Dipeptidase HPK19_RS09270 ENOG4105MCT stage V sporulation protein S HPK19_RS09275 ENOG4105D48 metallophosphoesterase HPK19_RS09280 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) HPK19_RS09290 ENOG4105CEV competence damage-inducible protein HPK19_RS09295 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HPK19_RS09310 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HPK19_RS09330 ENOG4105UIB (ABC) transporter HPK19_RS09335 ENOG4108JQ9 ABC transporter HPK19_RS09340 ENOG4107TFB basic membrane HPK19_RS09345 ENOG4105FDP GntR family transcriptional regulator HPK19_RS09350 ENOG4105CNU cell division protein FtsK HPK19_RS09360 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HPK19_RS09370 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HPK19_RS09375 ENOG4107STQ Multicopper oxidase HPK19_RS09380 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPK19_RS09390 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HPK19_RS09395 ENOG4108S0H Dipicolinic acid synthetase, b subunit HPK19_RS09415 ENOG4108S0H Dipicolinic acid synthetase, b subunit HPK19_RS09420 ENOG4105E35 Dipicolinate synthase subunit A HPK19_RS09425 ENOG4105C1V Peptidase, M16 HPK19_RS09435 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HPK19_RS09440 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HPK19_RS09445 ENOG4105DTN riboflavin biosynthesis protein ribF HPK19_RS09460 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HPK19_RS09465 ENOG4105VHM ribosomal protein HPK19_RS09470 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HPK19_RS09475 ENOG4105CHV Transcription elongation factor NusA HPK19_RS09480 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HPK19_RS09485 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HPK19_RS09495 ENOG4105DZP Membrane-associated zinc metalloprotease HPK19_RS09500 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HPK19_RS09505 ENOG4105KNE Phosphatidate cytidylyltransferase HPK19_RS09515 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HPK19_RS09520 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HPK19_RS09525 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HPK19_RS09530 ENOG4105CE9 30S ribosomal protein S2 HPK19_RS09535 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPK19_RS09540 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) HPK19_RS09545 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HPK19_RS09550 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HPK19_RS09555 ENOG4108HE4 integrase family HPK19_RS09565 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HPK19_RS09575 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HPK19_RS09585 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HPK19_RS09590 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HPK19_RS09600 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HPK19_RS09610 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HPK19_RS09615 ENOG4105VB6 UPF0109 protein HPK19_RS09630 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) HPK19_RS09635 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HPK19_RS09640 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HPK19_RS09655 ENOG4105CHR reductase HPK19_RS09660 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HPK19_RS09670 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) HPK19_RS09675 ENOG4105CB5 ATP-dependent DNA helicase recG HPK19_RS09680 ENOG4105EJQ L-serine dehydratase HPK19_RS09690 ENOG4105DP4 dak2 domain fusion protein ylov HPK19_RS09695 ENOG4108ZAA Alkaline-shock protein HPK19_RS09700 ENOG4105VB9 50S ribosomal protein l28 HPK19_RS09710 ENOG4105FJ0 thiamine HPK19_RS09715 ENOG4105DJV ribulose-phosphate 3-epimerase HPK19_RS09720 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HPK19_RS09725 ENOG4105D9P serine threonine protein kinase HPK19_RS09730 ENOG4108ZF3 Phosphatase HPK19_RS09735 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HPK19_RS09740 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HPK19_RS09745 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HPK19_RS09755 ENOG4105C25 Primosomal protein n' HPK19_RS09760 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HPK19_RS09775 ENOG4105DSJ YicC domain protein HPK19_RS09800 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HPK19_RS09805 ENOG41081VB Hydrolase HPK19_RS09810 ENOG4105BZ1 (ABC) transporter HPK19_RS09815 ENOG4105BZ1 (ABC) transporter HPK19_RS09830 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) HPK19_RS09855 ENOG4105EKQ RNA-directed DNA polymerase HPK19_RS09870 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HPK19_RS09885 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HPK19_RS09890 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HPK19_RS09895 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HPK19_RS09900 ENOG4105CD3 dihydroorotase HPK19_RS09905 ENOG4105CXT aspartate transcarbamylase HPK19_RS09920 ENOG4105C34 Pseudouridine synthase HPK19_RS09940 ENOG4105K4I Scp-like extracellular HPK19_RS09955 ENOG4105DBK s4 domain protein HPK19_RS09960 ENOG41067XK integral membrane protein HPK19_RS09965 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HPK19_RS09970 ENOG4105DFA alanine racemase domain protein HPK19_RS09975 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HPK19_RS09980 ENOG4105WR5 sporulation protein, YlmC YmxH family HPK19_RS09990 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPK19_RS09995 ENOG4108AWX Sporulation factor SpoIIGA HPK19_RS10005 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HPK19_RS10010 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HPK19_RS10015 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) HPK19_RS10020 ENOG4105D4A Cell wall formation (By similarity) HPK19_RS10030 ENOG4105CNI cell division protein FtsW HPK19_RS10040 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HPK19_RS10045 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HPK19_RS10050 ENOG4105CJN penicillin-binding protein HPK19_RS10055 ENOG4105CJN penicillin-binding protein HPK19_RS10065 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HPK19_RS10070 ENOG4108V6E Cell division protein mraZ HPK19_RS10085 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HPK19_RS10100 ENOG4105E39 Enoyl-CoA hydratase HPK19_RS10110 ENOG4105KNH Nucleic acid-binding protein HPK19_RS10115 ENOG4105CDE UPF0348 protein HPK19_RS10120 ENOG41063PX domain protein HPK19_RS10125 ENOG4105D78 K07001 NTE family protein HPK19_RS10130 ENOG4105H20 Sporulation integral membrane protein YlbJ HPK19_RS10135 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HPK19_RS10140 ENOG4106H78 methyltransferase HPK19_RS10150 ENOG4105WUC UPF0298 protein HPK19_RS10160 ENOG4107TB6 phosphoglycerate mutase HPK19_RS10175 ENOG4106UY4 Inherit from COG: Scp-like extracellular HPK19_RS10195 ENOG4105DUM transcriptional regulator, lysR family HPK19_RS10200 ENOG41064X9 cytochrome C oxidase subunit IV HPK19_RS10205 ENOG4105CCU oxidase (Subunit III) HPK19_RS10210 ENOG4105BZ9 Cytochrome C oxidase, subunit I HPK19_RS10230 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HPK19_RS10235 ENOG4105CNI cell division protein FtsW HPK19_RS10240 ENOG4105ZPI UPF0358 protein HPK19_RS10250 ENOG4108IAB Phoh family HPK19_RS10270 ENOG4105QA2 HPK19_RS10275 ENOG4105CI3 gtp-binding protein typa HPK19_RS10285 ENOG4105ECY inositol monophosphatase HPK19_RS10300 ENOG4105WBI UPF0223 protein HPK19_RS10305 ENOG4105CXN decarboxylase HPK19_RS10345 ENOG4105CPP Dehydrogenase, E1 component HPK19_RS10365 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HPK19_RS10370 ENOG4108X4Q Hydrolase HPK19_RS10385 ENOG4105CN5 Metallo-Beta-Lactamase HPK19_RS10405 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPK19_RS10410 ENOG4105D3R alkyl hydroperoxide reductase HPK19_RS10415 ENOG4105CH2 amidohydrolase HPK19_RS10440 ENOG4108XRC Protein of unknown function (DUF458) HPK19_RS10445 ENOG4107IN1 Protein of unknown function (DUF1797) HPK19_RS10460 ENOG4105EPM Diguanylate phosphodiesterase HPK19_RS10465 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HPK19_RS10480 ENOG4105UIN HPK19_RS10495 ENOG4108HGU Histidine kinase HPK19_RS10500 ENOG4105D7N magnesium and cobalt transport protein CorA HPK19_RS10505 ENOG4105CHM Aminotransferase HPK19_RS10515 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPK19_RS10525 ENOG41082YX Transcriptional regulator, arsr family HPK19_RS10530 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HPK19_RS10545 ENOG4105CID antiterminator HPK19_RS10550 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HPK19_RS10565 ENOG4105CE4 GlcNAc 6-P deacetylase HPK19_RS10570 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HPK19_RS10595 ENOG4105I3N Conserved Protein HPK19_RS10600 ENOG4105BZU Histidine kinase HPK19_RS10610 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPK19_RS10615 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPK19_RS10620 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HPK19_RS10650 ENOG41090MY MarR family Transcriptional regulator HPK19_RS10660 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HPK19_RS10665 ENOG4107G43 radical SAM domain protein HPK19_RS10690 ENOG4105H67 Protein of unknown function (DUF421) HPK19_RS10705 ENOG4105CHR reductase HPK19_RS10725 ENOG4108Z7G MaoC domain protein dehydratase HPK19_RS10730 ENOG410681C small acid-soluble spore protein HPK19_RS10745 ENOG4105K4I Scp-like extracellular HPK19_RS10750 ENOG4106N3A copper homeostasis protein cutc HPK19_RS10755 ENOG4108YBP pseudouridine synthase HPK19_RS10760 ENOG4105C0A alcohol dehydrogenase HPK19_RS10765 ENOG4108JYZ YitT family HPK19_RS10780 ENOG4107RUE extracellular solute-binding protein family 1 HPK19_RS10785 ENOG4105D38 putrescine abc transporter HPK19_RS10790 ENOG4105F38 ABC transporter, permease HPK19_RS10795 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPK19_RS10800 ENOG4105C26 Dehydrogenase HPK19_RS10805 ENOG4107GRR phosphate transport regulator HPK19_RS10810 ENOG4105CJ3 phosphate transporter HPK19_RS10815 ENOG4105DZ1 carboxypeptidase HPK19_RS10825 ENOG4105EU0 Major facilitator Superfamily HPK19_RS10830 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HPK19_RS10850 ENOG4105BZ9 Cytochrome C oxidase, subunit I HPK19_RS10855 ENOG4105E2S oxidase) subunit II HPK19_RS10895 ENOG4105PNM synthesis protein HPK19_RS10900 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HPK19_RS10915 ENOG4105DTQ mandelate racemase muconate lactonizing HPK19_RS10945 ENOG4105C6Y Udp-glucose 6-dehydrogenase HPK19_RS10950 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HPK19_RS10955 ENOG4107SBE Glycosyl transferase (Group 1 HPK19_RS10960 ENOG4108KS4 Spore coat protein HPK19_RS10970 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS10985 ENOG4108Q8B Spore germination protein HPK19_RS10990 ENOG4108NHD germination protein HPK19_RS10995 ENOG4108KS4 Spore coat protein HPK19_RS11010 ENOG4105E1K spore germination protein HPK19_RS11015 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11020 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HPK19_RS11025 ENOG4105C85 amino acid HPK19_RS11030 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HPK19_RS11035 ENOG4105XEA Tetr family transcriptional regulator HPK19_RS11040 ENOG4105CEY Amp-dependent synthetase and ligase HPK19_RS11070 ENOG4108IQI permease HPK19_RS11075 ENOG4105EUZ Beta-lactamase domain protein HPK19_RS11080 ENOG4105E1K spore germination protein HPK19_RS11085 ENOG4107R11 Transcriptional regulator HPK19_RS11090 ENOG4106F5Q Membrane HPK19_RS11105 ENOG4108XHQ (2Fe-2S)-binding domain protein HPK19_RS11115 ENOG4105C7W Xanthine dehydrogenase HPK19_RS11125 ENOG4108B31 Spore germination protein HPK19_RS11135 ENOG4105DUM transcriptional regulator, lysR family HPK19_RS11140 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11145 ENOG4106P55 Transcriptional regulator HPK19_RS11150 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11155 ENOG4105C0X amino acid HPK19_RS11170 ENOG4107R5R arsenical pump membrane protein HPK19_RS11175 ENOG4105VUF Transcriptional regulator HPK19_RS11180 ENOG4105CHR reductase HPK19_RS11190 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HPK19_RS11195 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HPK19_RS11220 ENOG4105ECB domain protein HPK19_RS11225 ENOG4105ST3 Transcriptional regulator HPK19_RS11230 ENOG4107RSM transcriptional regulator HPK19_RS11235 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11245 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPK19_RS11250 ENOG4105C26 Dehydrogenase HPK19_RS11265 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HPK19_RS11270 ENOG4105BZ8 glutamate synthase HPK19_RS11300 ENOG4108Q5U germination protein, ger(x)c family HPK19_RS11310 ENOG4105DTQ mandelate racemase muconate lactonizing HPK19_RS11320 ENOG4105CGH 5'-nucleotidase HPK19_RS11325 ENOG4105CVI Transcriptional regulator HPK19_RS11340 ENOG4105E1V na solute symporter HPK19_RS11350 ENOG4105DVW rieske (2Fe-2S) HPK19_RS11360 ENOG4105C26 Dehydrogenase HPK19_RS11365 ENOG4105C7K acetolactate synthase HPK19_RS11370 ENOG4105C1G acyl-Coa dehydrogenase HPK19_RS11375 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPK19_RS11385 ENOG4105D82 Glutamate dehydrogenase HPK19_RS11390 ENOG4108IQI permease HPK19_RS11395 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11400 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11410 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11415 ENOG4105E1K spore germination protein HPK19_RS11420 ENOG4108Q8B Spore germination protein HPK19_RS11440 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11445 ENOG4105CPC Aldo Keto reductase HPK19_RS11460 ENOG4105FBW Monooxygenase HPK19_RS11465 ENOG4105VUF Transcriptional regulator HPK19_RS11470 ENOG4105DQ4 alcohol dehydrogenase HPK19_RS11490 ENOG4108Z5V transcriptional regulator, merr family HPK19_RS11520 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HPK19_RS11530 ENOG4105C6Y Udp-glucose 6-dehydrogenase HPK19_RS11540 ENOG4105CKK Glycosyl transferase, family 2 HPK19_RS11550 ENOG41067TZ transcriptional regulator, MarR family HPK19_RS11575 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11580 ENOG4105CHR reductase HPK19_RS11585 ENOG4105CHR reductase HPK19_RS11605 ENOG4105C1G acyl-Coa dehydrogenase HPK19_RS11610 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPK19_RS11615 ENOG4105CHU acetyl-coa acetyltransferase HPK19_RS11620 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HPK19_RS11645 ENOG4105CHR reductase HPK19_RS11650 ENOG4105CEY Amp-dependent synthetase and ligase HPK19_RS11655 ENOG4105CEY Amp-dependent synthetase and ligase HPK19_RS11660 ENOG4105E39 Enoyl-CoA hydratase HPK19_RS11665 ENOG4105C1G acyl-Coa dehydrogenase HPK19_RS11670 ENOG4105CHU acetyl-coa acetyltransferase HPK19_RS11675 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPK19_RS11685 ENOG4105CR8 Transcriptional regulator HPK19_RS11695 ENOG4105ECQ AraC Family Transcriptional Regulator HPK19_RS11700 ENOG4108VP3 Lysine exporter protein (LysE YggA) HPK19_RS11715 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11720 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11725 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11730 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11735 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11740 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11755 ENOG4108QT4 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11760 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11765 ENOG4105DUM transcriptional regulator, lysR family HPK19_RS11770 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11775 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11780 ENOG4105DUM transcriptional regulator, lysR family HPK19_RS11790 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11795 ENOG4105DZ2 Transcriptional regulator HPK19_RS11800 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS11835 ENOG4108V06 Glutathione peroxidase HPK19_RS11895 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) HPK19_RS11950 ENOG4105ENA helicase HPK19_RS12000 ENOG4105EMS pseudouridine synthase HPK19_RS12015 ENOG4106EFP UPF0738 protein HPK19_RS12020 ENOG4105MIX Adenylate cyclase HPK19_RS12030 ENOG4105DPN Oligoendopeptidase f HPK19_RS12040 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HPK19_RS12050 ENOG4108ZCF integral membrane protein HPK19_RS12065 ENOG4108JQ7 (ABC) transporter HPK19_RS12075 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPK19_RS12080 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPK19_RS12090 ENOG4105C31 Tryptophanyl-tRNA synthetase HPK19_RS12105 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPK19_RS12110 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HPK19_RS12135 ENOG4108KP7 hydrolase HPK19_RS12155 ENOG4107AYK membrAne HPK19_RS12165 ENOG4107AYK membrAne HPK19_RS12170 ENOG4105QNR S1 RNA binding domain protein HPK19_RS12175 ENOG4108VPT UPF0234 protein HPK19_RS12180 ENOG4105FKQ transcriptional regulator HPK19_RS12185 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HPK19_RS12195 ENOG4105BZU Histidine kinase HPK19_RS12205 ENOG4105CAQ asparagine synthetase HPK19_RS12215 ENOG4106BKT UPF0344 protein HPK19_RS12255 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HPK19_RS12275 ENOG4105XVF Competence transcription factor HPK19_RS12285 ENOG4107QP3 malate synthase g HPK19_RS12290 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HPK19_RS12295 ENOG4105CEY Amp-dependent synthetase and ligase HPK19_RS12300 ENOG4105DF9 Lipoate-protein, ligase HPK19_RS12305 ENOG4108RQ5 Beta-lactamase domain-containing protein HPK19_RS12315 ENOG4105C1Q protoporphyrinogen oxidase HPK19_RS12320 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HPK19_RS12325 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HPK19_RS12330 ENOG4105BZ4 penicillin-binding protein HPK19_RS12355 ENOG4105K59 histidine triad (HIT) protein HPK19_RS12385 ENOG4105EQI Metal Dependent Phosphohydrolase HPK19_RS12400 ENOG4105CGU Enoyl-CoA hydratase HPK19_RS12405 ENOG4105D4P Coproporphyrinogen iii oxidase HPK19_RS12430 ENOG410839P HPK19_RS12455 ENOG4105YWU small acid-soluble spore protein HPK19_RS12460 ENOG4105CDA abc transporter atp-binding protein HPK19_RS12465 ENOG4105DRP amino acid AbC transporter HPK19_RS12475 ENOG4108JU5 Magnesium and cobalt efflux protein HPK19_RS12480 ENOG4105C37 (CBS) domain HPK19_RS12495 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HPK19_RS12500 ENOG4108JQ1 Dehydrogenase HPK19_RS12505 ENOG4105CHU acetyl-coa acetyltransferase HPK19_RS12510 ENOG4108JUB Transcriptional regulator HPK19_RS12515 ENOG4105DTD Dehydrogenase HPK19_RS12520 ENOG4108IIH CoA-transferase subunit B HPK19_RS12525 ENOG4105D6N CoA-transferase, subunit a HPK19_RS12530 ENOG4105CY2 Citrate transporter HPK19_RS12540 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS12545 ENOG4107RGJ metallophosphoesterase HPK19_RS12550 ENOG4108UW5 maltose o-acetyltransferase HPK19_RS12555 ENOG410829K Lysine exporter protein (Lyse ygga) HPK19_RS12565 ENOG4105CH7 arginosuccinase HPK19_RS12570 ENOG4105CDH Citrulline--aspartate ligase HPK19_RS12575 ENOG4105DBV ornithine carbamoyltransferase HPK19_RS12580 ENOG4105HUF DNA protection during starvation protein HPK19_RS12585 ENOG410756H nucleotidyltransferase HPK19_RS12610 ENOG4107T5V SNARE associated Golgi HPK19_RS12615 ENOG4105C59 p-type ATPase HPK19_RS12650 ENOG4107VC0 DNA alkylation repair enzyme HPK19_RS12660 ENOG4108V2W Carbonate dehydratase HPK19_RS12670 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HPK19_RS12690 ENOG4105GR3 Histidine kinase HPK19_RS12695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPK19_RS12710 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) HPK19_RS12720 ENOG4108UGV hypoxanthine phosphoribosyltransferase HPK19_RS12740 ENOG4105E0Y RtcB Protein HPK19_RS12750 ENOG4105KD7 acetyltransferase HPK19_RS12760 ENOG4105DAP Nicotinate phosphoribosyltransferase HPK19_RS12765 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HPK19_RS12770 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HPK19_RS12790 ENOG4107Y9E nuclease HPK19_RS12795 ENOG4105D03 DNA-3-methyladenine glycosylase II HPK19_RS12825 ENOG4105FGV Chromate HPK19_RS12830 ENOG4105CAH Chromate HPK19_RS12845 ENOG4107XBN GntR Family Transcriptional Regulator HPK19_RS12895 ENOG4105KAC Antibiotic biosynthesis monooxygenase HPK19_RS12905 ENOG4108SUT Major Facilitator Superfamily HPK19_RS12940 ENOG4105BZU Histidine kinase HPK19_RS12945 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPK19_RS12970 ENOG41080E2 ribosomal-protein-alanine acetyltransferase HPK19_RS13005 ENOG4105CDY transcriptional regulatory protein HPK19_RS13025 ENOG4105CH6 catalase HPK19_RS13040 ENOG4105DQ6 Transposase HPK19_RS13050 ENOG4108JPW Aminotransferase HPK19_RS13055 ENOG4108KAZ Involved in phosphonate degradation (By similarity) HPK19_RS13060 ENOG4107STF Involved in phosphonate degradation (By similarity) HPK19_RS13075 ENOG4105E98 transcriptional regulator DeoR family HPK19_RS13100 ENOG4105DAA L-lactate HPK19_RS13115 ENOG4108JJB ABC transporter HPK19_RS13155 ENOG4105E1V na solute symporter HPK19_RS13170 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HPK19_RS13180 ENOG4105DVW rieske (2Fe-2S) HPK19_RS13190 ENOG4108KGH TRANSCRIPTIONal HPK19_RS13200 ENOG4105DQ6 Transposase HPK19_RS13230 ENOG4108UX3 '-nucleotidase HPK19_RS13235 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HPK19_RS13240 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HPK19_RS13250 ENOG4105KVH Transcriptional regulator HPK19_RS13255 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS13260 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS13265 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS13275 ENOG4108KB2 LysR family Transcriptional regulator HPK19_RS13305 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS13325 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HPK19_RS13340 ENOG4105D8G Major Facilitator superfamily HPK19_RS13355 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HPK19_RS13360 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HPK19_RS13405 ENOG41069H0 dihydroorotase EC 3.5.2.3 HPK19_RS13425 ENOG4107RBB ABC transporter, permease HPK19_RS13430 ENOG4105C19 ABC transporter HPK19_RS13440 ENOG4105E1V na solute symporter HPK19_RS13445 ENOG4106CAD Protein of unknown function (DUF3311) HPK19_RS13470 ENOG4105CH2 amidohydrolase HPK19_RS13490 ENOG4105VMP Transcriptional regulator HPK19_RS13495 ENOG4105CBC glutamate synthase HPK19_RS13520 ENOG4108I5G Major Facilitator superfamily HPK19_RS13525 ENOG4106448 streptomycin biosynthesis protein strI HPK19_RS13530 ENOG4106KNT transcriptional regulator HPK19_RS13535 ENOG4105RD7 BadF BadG BcrA BcrD HPK19_RS13540 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HPK19_RS13545 ENOG4105CS2 ec 3.2.1.21 HPK19_RS13550 ENOG4105VCP PTS System HPK19_RS13555 ENOG4105CK1 PTS System HPK19_RS13560 ENOG4105VZJ PTS System HPK19_RS13565 ENOG4105EMD TRANSCRIPTIONal HPK19_RS13580 ENOG4105C5X domain protein HPK19_RS13585 ENOG4105DJB Major Facilitator Superfamily HPK19_RS13600 ENOG4105ED1 spovr family HPK19_RS13625 ENOG4105C7N Xanthine uracil vitamin C permease HPK19_RS13635 ENOG4108NRW Phospholipase, patatin family HPK19_RS13640 ENOG4105CUJ penicillin amidase HPK19_RS13650 ENOG4106A3R peptidase HPK19_RS13675 ENOG41080UX Methyltransferase HPK19_RS13685 ENOG4105W8X HesB YadR YfhF-family protein HPK19_RS13695 ENOG4105BZU Histidine kinase HPK19_RS13720 ENOG4105K56 Transcriptional regulator HPK19_RS13730 ENOG4105C4B ABC transporter, permease HPK19_RS13735 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPK19_RS13740 ENOG4105E0A ABC, transporter HPK19_RS13745 ENOG4108IHU transport system permease protein HPK19_RS13750 ENOG4105DQ5 transport system permease protein HPK19_RS13755 ENOG4108MES Periplasmic binding protein HPK19_RS13765 ENOG4108MRH transcriptional regulatory protein HPK19_RS13770 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HPK19_RS13785 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HPK19_RS13800 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HPK19_RS13810 ENOG4105US7 Histidine kinase HPK19_RS13815 ENOG4108STX response regulator HPK19_RS13845 ENOG4105EHG Permease protein HPK19_RS13850 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HPK19_RS13855 ENOG4108WHG pyridoxamine 5'-phosphate HPK19_RS13870 ENOG4105F1N DNA alkylation repair HPK19_RS13885 ENOG4108TGR phosphatase HPK19_RS13890 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HPK19_RS13895 ENOG4108YZT Adenosylcobinamide kinase HPK19_RS13915 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS13920 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS13930 ENOG4106KNT transcriptional regulator HPK19_RS13945 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS13955 ENOG4108Z66 YbaK ebsC protein HPK19_RS13985 ENOG4108R6K riboflavin synthase, subunit alpha HPK19_RS13995 ENOG4107V2S Transcriptional regulator HPK19_RS14015 ENOG41069DP small acid-soluble spore protein HPK19_RS14020 ENOG4105CUB amino acid HPK19_RS14050 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HPK19_RS14055 ENOG4108VEU Thiamine monophosphate synthase HPK19_RS14070 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HPK19_RS14075 ENOG4105D06 uba thif-type nad fad binding protein HPK19_RS14085 ENOG4105C26 Dehydrogenase HPK19_RS14090 ENOG4108IJ0 Aspartate ammonia-lyase HPK19_RS14095 ENOG41069M3 Transcriptional regulator HPK19_RS14100 ENOG4105C54 Major Facilitator superfamily HPK19_RS14105 ENOG410681U heavy metal transport detoxification protein HPK19_RS14110 ENOG4105C59 p-type ATPase HPK19_RS14115 ENOG4105VPX protein, conserved in bacteria HPK19_RS14130 ENOG4105CSU acyl-Coa dehydrogenase HPK19_RS14135 ENOG4108Z6Z Transcriptional regulator HPK19_RS14140 ENOG4105C7K acetolactate synthase HPK19_RS14145 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HPK19_RS14150 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) HPK19_RS14195 ENOG4105D4Y metalloprotease HPK19_RS14215 ENOG4108B31 Spore germination protein HPK19_RS14250 ENOG4105DYB Isoaspartyl dipeptidase HPK19_RS14260 ENOG4105D01 (LipO)protein HPK19_RS14265 ENOG4108UMI ABC transporter, permease HPK19_RS14270 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPK19_RS14280 ENOG41087NI Sulfite exporter TauE/SafE HPK19_RS14285 ENOG4105VFE sira family HPK19_RS14290 ENOG4107TPS domain protein HPK19_RS14295 ENOG4105VFE sira family HPK19_RS14305 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase HPK19_RS14310 ENOG4105XTG Pfam:DUF156 HPK19_RS14325 ENOG4105CAH Chromate HPK19_RS14335 ENOG4108Q8B Spore germination protein HPK19_RS14355 ENOG4105BZW Glycerate kinase HPK19_RS14360 ENOG4105C71 hydrolase family 65, central catalytic HPK19_RS14365 ENOG4105CK5 oxidoreductase HPK19_RS14370 ENOG4107TYA transient receptor potential locus HPK19_RS14375 ENOG4107RRD Dehydrogenase HPK19_RS14380 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HPK19_RS14385 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HPK19_RS14390 ENOG4105WEM extracellular solute-binding protein HPK19_RS14395 ENOG4107QW3 Sucrose phosphorylase HPK19_RS14400 ENOG4105FKQ transcriptional regulator HPK19_RS14405 ENOG4107URF beta-phospho-glucomutase HPK19_RS14415 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HPK19_RS14425 ENOG4107ZTW SNARE associated Golgi HPK19_RS14430 ENOG41062D9 Histidine kinase HPK19_RS14435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPK19_RS14470 ENOG4108U5N UPF0316 protein HPK19_RS14475 ENOG41067SE Tetr family transcriptional regulator HPK19_RS14480 ENOG4105EYF MMPL domain protein HPK19_RS14490 ENOG4105DQ6 Transposase HPK19_RS14500 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 HPK19_RS14505 ENOG4108U05 Transcriptional regulator HPK19_RS14510 ENOG41082BV acetyltransferase HPK19_RS14520 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HPK19_RS14535 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS14545 ENOG4105W7K Transcriptional regulator HPK19_RS14560 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS14570 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS14575 ENOG4105HBA AroM protein HPK19_RS14610 ENOG4108QY0 Membrane HPK19_RS14620 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS14625 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS14650 ENOG4105WYW fructose-bisphosphate aldolase HPK19_RS14665 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HPK19_RS14670 ENOG4107Y2X deaminase HPK19_RS14675 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HPK19_RS14680 ENOG4105C5B carbamate kinase HPK19_RS14690 ENOG4107REC cytoplasmic protein HPK19_RS14695 ENOG4107R1Q Membrane protein FdrA HPK19_RS14705 ENOG4105G9B Transcriptional regulator HPK19_RS14725 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPK19_RS14730 ENOG4108UZ3 Transporter HPK19_RS14740 ENOG4108V2W Carbonate dehydratase HPK19_RS14760 ENOG41061CK Antibiotic biosynthesis monooxygenase HPK19_RS14775 ENOG4105EKQ RNA-directed DNA polymerase HPK19_RS14790 ENOG4107QM2 Aldo Keto reductase HPK19_RS14795 ENOG4105CYN Serine protein kinase HPK19_RS14800 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HPK19_RS14810 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HPK19_RS14915 ENOG4105KT7 mgtC SapB transporter HPK19_RS14920 ENOG4107PBV potassium channel HPK19_RS14935 ENOG4105WG9 Conserved Protein HPK19_RS14945 ENOG4108MUZ hydrolase HPK19_RS14950 ENOG4105BZU Histidine kinase HPK19_RS14955 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPK19_RS14980 ENOG4105BZ4 penicillin-binding protein HPK19_RS14990 ENOG4105KA0 thioesterase Superfamily protein HPK19_RS15000 ENOG41069ER domain protein HPK19_RS15015 ENOG4105CEP NADH dehydrogenase HPK19_RS15025 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HPK19_RS15030 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HPK19_RS15035 ENOG4105ZKE UPF0349 protein HPK19_RS15060 ENOG41083MR nifu domain-containing protein HPK19_RS15070 ENOG4108W5N phosphatidylglycerophosphatase a HPK19_RS15075 ENOG4105D4U had-superfamily hydrolase, subfamily iia HPK19_RS15090 ENOG4105MMD transcriptional regulator HPK19_RS15105 ENOG4105FAA peptidase M23 HPK19_RS15115 ENOG4105CPI Metal Dependent Phosphohydrolase HPK19_RS15120 ENOG4105KZD Domain of unknown function (DUF1805) HPK19_RS15125 ENOG4107R8B 5'-nucleotidase HPK19_RS15140 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS15145 ENOG4105DIW FeS assembly protein SUFB HPK19_RS15150 ENOG4108UNV SUF system FeS assembly protein, NifU family HPK19_RS15160 ENOG4105JRK feS assembly protein SufD HPK19_RS15165 ENOG4105C3K feS assembly ATPase SufC HPK19_RS15180 ENOG4108A04 Beta-lactamase HPK19_RS15195 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HPK19_RS15200 ENOG4106C1H Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) HPK19_RS15205 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HPK19_RS15210 ENOG4105C5I Dehydrogenase HPK19_RS15215 ENOG4105D01 (LipO)protein HPK19_RS15220 ENOG4108UMI ABC transporter, permease HPK19_RS15225 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPK19_RS15245 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HPK19_RS15250 ENOG41080E8 Transcriptional regulator, Spx MgsR family HPK19_RS15255 ENOG4105C1G acyl-Coa dehydrogenase HPK19_RS15260 ENOG4105CHU acetyl-coa acetyltransferase HPK19_RS15285 ENOG4108QTI )-transporter HPK19_RS15290 ENOG41090WU lipolytic protein G-D-S-L family HPK19_RS15295 ENOG4105CJ1 ABC, transporter HPK19_RS15300 ENOG4108TU7 Inherit from COG: (ABC) transporter HPK19_RS15315 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) HPK19_RS15320 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HPK19_RS15335 ENOG4105CIG ABC transporter HPK19_RS15355 ENOG4105CJ1 ABC, transporter HPK19_RS15370 ENOG4108URH decarboxylase HPK19_RS15375 ENOG4105EE0 oxidoreductase HPK19_RS15390 ENOG4105C5H ABC transporter HPK19_RS15400 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HPK19_RS15425 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HPK19_RS15430 ENOG4105E0A ABC, transporter HPK19_RS15435 ENOG4105TVJ transport system, permease HPK19_RS15440 ENOG4105DQ5 transport system permease protein HPK19_RS15445 ENOG4108HUF Transporter HPK19_RS15455 ENOG4108TTB tellurium resistance protein HPK19_RS15465 ENOG4106FN3 tellurium resistance protein HPK19_RS15470 ENOG4108N0M stress protein HPK19_RS15485 ENOG4108PJD permease HPK19_RS15490 ENOG4108NNR transporter substrate-binding protein HPK19_RS15505 ENOG4105KTB nuclear export factor GLE1 HPK19_RS15520 ENOG4105WEF catalase HPK19_RS15545 ENOG4108JJ8 (ABC) transporter HPK19_RS15550 ENOG4108JJ9 ABC, transporter HPK19_RS15555 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPK19_RS15560 ENOG4105C4M (Ubiquinol oxidase) subunit I HPK19_RS15565 ENOG4105FGV Chromate HPK19_RS15570 ENOG4105FGV Chromate HPK19_RS15575 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HPK19_RS15580 ENOG4108JQ7 (ABC) transporter HPK19_RS15585 ENOG4105C3U ABC transporter HPK19_RS15595 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPK19_RS15610 ENOG4105ECB domain protein HPK19_RS15625 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HPK19_RS15635 ENOG4105ST3 Transcriptional regulator HPK19_RS15645 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS15720 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HPK19_RS15725 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HPK19_RS15745 ENOG4105XZU Preprotein translocase, subunit SecG HPK19_RS15765 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HPK19_RS15770 ENOG4105C9X ppx gppa phosphatase HPK19_RS15785 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HPK19_RS15790 ENOG4105CP7 Triose-phosphate isomerase HPK19_RS15795 ENOG4105BZA Phosphoglycerate kinase HPK19_RS15815 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPK19_RS15820 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPK19_RS15830 ENOG4105F8D glycoside hydrolase family 4 HPK19_RS15835 ENOG4105VCP PTS System HPK19_RS15840 ENOG4105CK1 PTS System HPK19_RS15850 ENOG4105VCP PTS System HPK19_RS15855 ENOG4105CK1 PTS System HPK19_RS15880 ENOG4105CS2 ec 3.2.1.21 HPK19_RS15890 ENOG4105KRI phosphocarrier protein (HPr HPK19_RS15900 ENOG4105CHW UPF0052 protein HPK19_RS15905 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HPK19_RS15910 ENOG4108Z4K mutator MutT protein HPK19_RS15915 ENOG4105C3M thioredoxin reductase HPK19_RS15925 ENOG4108S4C acetyltransferase HPK19_RS15935 ENOG4105HKU nucleoside recognition domain-containing protein HPK19_RS15940 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HPK19_RS15950 ENOG41086DT Membrane protein of unknown function HPK19_RS15960 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HPK19_RS15965 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HPK19_RS15980 ENOG4105CJ1 ABC, transporter HPK19_RS15985 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HPK19_RS16005 ENOG4107XWI flavin reductase domain protein, FMN-binding HPK19_RS16010 ENOG4105FBA Phospholipase Carboxylesterase HPK19_RS16015 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HPK19_RS16040 ENOG4105EU9 HPK19_RS16050 ENOG4105C3M thioredoxin reductase HPK19_RS16080 ENOG4108RYK Nad-dependent epimerase dehydratase HPK19_RS16085 ENOG4108Z40 Transcriptional regulator HPK19_RS16095 ENOG4105EW9 transcriptional regulator AsnC family HPK19_RS16105 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HPK19_RS16115 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HPK19_RS16120 ENOG4105WH1 Two component transcriptional regulator luxr family HPK19_RS16125 ENOG4105BZU Histidine kinase HPK19_RS16135 ENOG4105D9U N-acetyltransferase HPK19_RS16150 ENOG4105MIR Phenylalanine 4-monooxygenase HPK19_RS16160 ENOG4105VKD bioY protein HPK19_RS16180 ENOG4105CJZ response regulator HPK19_RS16195 ENOG4105C19 ABC transporter HPK19_RS16200 ENOG4107QX3 carboxylase HPK19_RS16205 ENOG4105E39 Enoyl-CoA hydratase HPK19_RS16210 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HPK19_RS16220 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HPK19_RS16225 ENOG4105C1G acyl-Coa dehydrogenase HPK19_RS16230 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HPK19_RS16235 ENOG4105YA8 Transcriptional regulator HPK19_RS16250 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HPK19_RS16255 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HPK19_RS16275 ENOG4107SJW iron permease, FTR1 HPK19_RS16305 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HPK19_RS16315 ENOG4105DK0 Indole-3-glycerol phosphate synthase HPK19_RS16320 ENOG4108I0Q anthranilate phosphoribosyltransferase HPK19_RS16325 ENOG4105DDQ anthranilate synthase HPK19_RS16330 ENOG4105CRQ synthase (Component I) HPK19_RS16335 ENOG4105E1K spore germination protein HPK19_RS16350 ENOG4107GRR phosphate transport regulator HPK19_RS16360 ENOG4108W6C Dehydrogenase HPK19_RS16365 ENOG4105DUM transcriptional regulator, lysR family HPK19_RS16375 ENOG4105C7N Xanthine uracil vitamin C permease HPK19_RS16380 ENOG4105FE9 pseudouridine synthase HPK19_RS16390 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS16400 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HPK19_RS16410 ENOG4105ETD TRANSCRIPTIONal HPK19_RS16425 ENOG4105CN1 protease HPK19_RS16430 ENOG4105CH6 catalase HPK19_RS16435 ENOG4105DR5 peptidase HPK19_RS16440 ENOG4105CRP Part of the ABC transporter FtsEX involved in HPK19_RS16445 ENOG4105CAK Cell division ATP-binding protein ftsE HPK19_RS16475 ENOG4105VEQ Cold shock protein HPK19_RS16480 ENOG4105C0X amino acid HPK19_RS16490 ENOG41081UC Inherit from COG: Competence protein HPK19_RS16505 ENOG4105WH1 Two component transcriptional regulator luxr family HPK19_RS16515 ENOG4108KGH TRANSCRIPTIONal HPK19_RS16520 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HPK19_RS16595 ENOG4105C3F Signal peptidase i HPK19_RS16610 ENOG4105DDI hemolysin-type calcium-binding region HPK19_RS16620 ENOG4107XGZ Hydrolase HPK19_RS16630 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HPK19_RS16645 ENOG4105BZ1 (ABC) transporter HPK19_RS16650 ENOG4108IMY Transcriptional regulator HPK19_RS16655 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HPK19_RS16660 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family HPK19_RS16665 ENOG4105D3Q Sugar transferase HPK19_RS16675 ENOG4107QRS glycosyltransferase group 2 family protein HPK19_RS16685 ENOG4107RA4 Glycosyl transferase (Group 1 HPK19_RS16695 ENOG4105K64 Glycosyl transferase, family 2 HPK19_RS16705 ENOG4108PQP glycosyl transferase group 1 HPK19_RS16715 ENOG4107YJ4 chain length determinant protein HPK19_RS16720 ENOG4105HTX biosynthesis protein HPK19_RS16725 ENOG4105EXC Acyl-transferase HPK19_RS16750 ENOG4108VJ1 Transcriptional regulator (CarD family HPK19_RS16755 ENOG4105VEQ Cold shock protein HPK19_RS16765 ENOG4105KBK Zinc finger, swim domain protein HPK19_RS16770 ENOG4105C0D helicase HPK19_RS16775 ENOG4105RHY Pfam:UPF0157 HPK19_RS16780 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HPK19_RS16805 ENOG4105E1K spore germination protein HPK19_RS16810 ENOG4105C6Y Udp-glucose 6-dehydrogenase HPK19_RS16820 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HPK19_RS16825 ENOG4105FRN stage II sporulation protein HPK19_RS16850 ENOG4106778 Protein of unknown function (DUF1146) HPK19_RS16855 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPK19_RS16860 ENOG4105C8S subunit m HPK19_RS16865 ENOG4105D65 subunit l HPK19_RS16870 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPK19_RS16895 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HPK19_RS16900 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPK19_RS16910 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPK19_RS16915 ENOG4105CW7 secretion protein, HlyD family HPK19_RS16920 ENOG4105ST3 Transcriptional regulator HPK19_RS16925 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HPK19_RS16935 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HPK19_RS16940 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HPK19_RS16960 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) HPK19_RS16975 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS16980 ENOG4105IW1 AmiS UreI transporter HPK19_RS16985 ENOG4105D9N nucleoside HPK19_RS16995 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HPK19_RS17000 ENOG4107RHR regulatoR HPK19_RS17005 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HPK19_RS17025 ENOG4108YZG isomerase HPK19_RS17040 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HPK19_RS17050 ENOG4108ZXQ stage ii sporulation protein r HPK19_RS17065 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HPK19_RS17070 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HPK19_RS17075 ENOG4107104 thymidine kinase HPK19_RS17085 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HPK19_RS17090 ENOG4105CBT Fructose-1,6-bisphosphatase HPK19_RS17095 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HPK19_RS17115 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HPK19_RS17125 ENOG4105D5P Methylmalonyl-coA mutase HPK19_RS17130 ENOG4105C1G acyl-Coa dehydrogenase HPK19_RS17140 ENOG4105DF6 Fe-S oxidoreductase HPK19_RS17190 ENOG4105DXB Major Facilitator superfamily HPK19_RS17195 ENOG4107SWG transcriptional regulator MERR family HPK19_RS17205 ENOG4105CYW agmatinase HPK19_RS17215 ENOG4105BZ4 penicillin-binding protein HPK19_RS17220 ENOG4108XFG YwhD family HPK19_RS17225 ENOG4108Z4T Peptidase M50 HPK19_RS17230 ENOG41069HH 4-oxalocrotonate tautomerase HPK19_RS17235 ENOG4105DCI Phosphohydrolase HPK19_RS17245 ENOG4108VCI transcription factor, rsfa family HPK19_RS17250 ENOG4108V5C ABC transporter HPK19_RS17260 ENOG4108IJ2 phosphate acetyltransferase HPK19_RS17265 ENOG4107JTW chlorite dismutase HPK19_RS17270 ENOG4108VKI Cell wall hydrolase HPK19_RS17290 ENOG410667J hydrolase HPK19_RS17295 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HPK19_RS17300 ENOG4105HMI Membrane HPK19_RS17305 ENOG4105CKK Glycosyl transferase, family 2 HPK19_RS17320 ENOG4105CJ1 ABC, transporter HPK19_RS17335 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HPK19_RS17340 ENOG4105C9U ATP-dependent DNA helicase RecQ HPK19_RS17345 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein HPK19_RS17355 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HPK19_RS17360 ENOG4105DR4 Methyltransferase HPK19_RS17365 ENOG4107414 GntR family transcriptional regulator HPK19_RS17370 ENOG4105CG3 alpha amylase, catalytic region HPK19_RS17375 ENOG4105C5Y PTS System HPK19_RS17420 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HPK19_RS17425 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HPK19_RS17435 ENOG4105E8R UPF0173 metal-dependent hydrolase HPK19_RS17440 ENOG4108IG5 Transcriptional regulator HPK19_RS17450 ENOG4105CJZ response regulator HPK19_RS17455 ENOG4105EWM Histidine kinase HPK19_RS17460 ENOG4105C19 ABC transporter HPK19_RS17475 ENOG4105VCD cytoplasmic protein HPK19_RS17480 ENOG4105D22 carbon starvation protein HPK19_RS17485 ENOG41067SE Tetr family transcriptional regulator HPK19_RS17490 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPK19_RS17500 ENOG4105DSG hydrolase family 43 HPK19_RS17505 ENOG4107SET aldo keto reductase HPK19_RS17510 ENOG4105CMG Carbohydrate kinase HPK19_RS17520 ENOG4108N2V aldose 1-epimerase HPK19_RS17545 ENOG4105EQD regulatoR HPK19_RS17550 ENOG4105C2F Histidine kinase HPK19_RS17555 ENOG4105EP9 oxidoreductase HPK19_RS17560 ENOG4105C5Y PTS System HPK19_RS17565 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HPK19_RS17590 ENOG4105EEM helicase HPK19_RS17595 ENOG4105CE4 GlcNAc 6-P deacetylase HPK19_RS17610 ENOG4105D2N Aldolase HPK19_RS17615 ENOG4105E70 isomerase HPK19_RS17630 ENOG4105DRS transport system, permease HPK19_RS17635 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HPK19_RS17645 ENOG4105DWT malate dehydrogenase (quinone) HPK19_RS17660 ENOG4105BZU Histidine kinase HPK19_RS17680 ENOG4105CI1 PTS System HPK19_RS17700 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HPK19_RS17710 ENOG4105Q2H domain protein HPK19_RS17725 ENOG4105BZU Histidine kinase HPK19_RS17730 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPK19_RS17755 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HPK19_RS17760 ENOG4105CDU Replicative dna helicase HPK19_RS17765 ENOG41082B8 Binds to the 23S rRNA (By similarity) HPK19_RS17770 ENOG4105BZR domain protein HPK19_RS17785 ENOG4108UUM single-stranded DNA-binding protein HPK19_RS17790 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HPK19_RS17795 ENOG4105C3G gtp-binding protein HPK19_RS17800 ENOG4105VDK protein, conserved in bacteria HPK19_RS17805 ENOG4105D8X mechanosensitive ion channel HPK19_RS17810 ENOG4108ZDA Sporulation protein YyaC HPK19_RS17815 ENOG4105FA0 parb-like partition protein HPK19_RS17820 ENOG4107QJE Chromosome Partitioning Protein HPK19_RS17835 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HPK19_RS17840 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HPK19_RS17850 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HPK19_RS17865 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HPK19_RS17870 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HPK19_RS17875 ENOG410848D S4 domain protein YaaA HPK19_RS17890 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPK19_RS17910 ENOG4105BZ1 (ABC) transporter HPK19_RS17915 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPK19_RS17920 ENOG4105BZU Histidine kinase HPK19_RS17945 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HPK19_RS17955 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HPK19_RS17960 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HPK19_RS17965 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HPK19_RS17975 ENOG4105ZMH deoxynucleoside kinase HPK19_RS17985 ENOG4105GTG Isochorismatase HPK19_RS17990 ENOG4108Z6B deaminase HPK19_RS18000 ENOG4105C6E dna polymerase iii HPK19_RS18005 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HPK19_RS18010 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HPK19_RS18055 ENOG4105CXN decarboxylase HPK19_RS18060 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HPK19_RS18065 ENOG4105FA2 dna polymerase iii HPK19_RS18070 ENOG4105MA4 psp1 domain protein HPK19_RS18075 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) HPK19_RS18080 ENOG41060K3 Methyltransferase HPK19_RS18085 ENOG4105VC4 domain protein HPK19_RS18090 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HPK19_RS18095 ENOG4105KRN Transcriptional regulator, abrb family HPK19_RS18105 ENOG4105F8V Hydrolase, tatD family HPK19_RS18110 ENOG41069ER domain protein HPK19_RS18115 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) HPK19_RS18125 ENOG4105XFA sporulation peptidase YabG HPK19_RS18130 ENOG4105W42 Veg protein HPK19_RS18145 ENOG4105DFT pur operon repressor HPK19_RS18150 ENOG4105KME endoribonuclease L-psp HPK19_RS18160 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HPK19_RS18180 ENOG4108JA2 transcriptioN-repair coupling factor HPK19_RS18185 ENOG4108M14 stage v sporulation protein t HPK19_RS18195 ENOG4108IY2 MazG family HPK19_RS18200 ENOG41082I2 s4 domain protein HPK19_RS18205 ENOG4105VYY sporulation protein yabp HPK19_RS18220 ENOG41060GV RNA binding s1 domain protein HPK19_RS18255 ENOG4108UGV hypoxanthine phosphoribosyltransferase HPK19_RS18260 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HPK19_RS18265 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HPK19_RS18275 ENOG4105C6T cysteine synthase HPK19_RS18280 ENOG4105CRQ synthase (Component I) HPK19_RS18285 ENOG4105DDQ anthranilate synthase HPK19_RS18290 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HPK19_RS18295 ENOG4105EEI dihydropteroate synthase HPK19_RS18300 ENOG4105KRF dihydroneopterin aldolase HPK19_RS18305 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HPK19_RS18315 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HPK19_RS18320 ENOG4105CRK lysyL-tRNA synthetase HPK19_RS18415 ENOG4108Z0C Uvrb UvrC protein HPK19_RS18420 ENOG41066A3 ATP guanido phosphotransferase HPK19_RS18430 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HPK19_RS18435 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HPK19_RS18440 ENOG4105CTP PilT protein domain protein HPK19_RS18445 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HPK19_RS18450 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HPK19_RS18455 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HPK19_RS18460 ENOG4105D7W serine acetyltransferase HPK19_RS18475 ENOG4105C2N RNA methyltransferase TrmH family group 3 HPK19_RS18480 ENOG4105M0M Tetracycline resistance protein HPK19_RS18485 ENOG4105QIV RNA polymerase HPK19_RS18500 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HPK19_RS18510 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HPK19_RS18515 ENOG4108VZM 50s ribosomal protein L10 HPK19_RS18525 ENOG4107Y49 methyltransferase HPK19_RS18545 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HPK19_RS18555 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HPK19_RS18565 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HPK19_RS18575 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HPK19_RS18595 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HPK19_RS18605 ENOG41082SA 50s ribosomal protein l29 HPK19_RS18610 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HPK19_RS18615 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HPK19_RS18630 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HPK19_RS18640 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HPK19_RS18645 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HPK19_RS18650 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HPK19_RS18655 ENOG4105VPB 50S ribosomal protein L30 HPK19_RS18665 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HPK19_RS18670 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HPK19_RS18685 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HPK19_RS18705 ENOG4108JJB ABC transporter HPK19_RS18715 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HPK19_RS18720 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HPK19_RS18725 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HPK19_RS18740 ENOG4108IJ0 Aspartate ammonia-lyase HPK19_RS18745 ENOG4105C6K Malic enzyme HPK19_RS18780 ENOG4105D1F ATP-binding protein HPK19_RS18790 ENOG4108NMV polysaccharide deacetylase HPK19_RS18865 ENOG4105C8B TIGR00159 family HPK19_RS18875 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HPK19_RS18910 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPK19_RS18915 ENOG4105BZU Histidine kinase HPK19_RS18920 ENOG4108Z5K methylglyoxal synthase HPK19_RS18930 ENOG4105KVH Transcriptional regulator HPK19_RS18935 ENOG4105F27 Major Facilitator HPK19_RS18940 ENOG4105CV8 reductase HPK19_RS18945 ENOG4105DQ6 Transposase HPK19_RS18970 ENOG4108VGI doxx family HPK19_RS18990 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HPK19_RS19000 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HPK19_RS19005 ENOG4105E0X reductase HPK19_RS19015 ENOG4105EV4 Multidrug resistance protein mdtH HPK19_RS19020 ENOG4105CPF Cell wall formation (By similarity) HPK19_RS19025 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HPK19_RS19030 ENOG4105C1J atp-dependent rna helicase HPK19_RS19040 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HPK19_RS19045 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HPK19_RS19050 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HPK19_RS19060 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HPK19_RS19175 ENOG4105K8N protein family UPF0079, ATPase HPK19_RS19180 ENOG41072GX Peptidase M22 Glycoprotease HPK19_RS19185 ENOG410801F ribosomal-protein-alanine acetyltransferase HPK19_RS19190 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HPK19_RS19195 ENOG4105C5H ABC transporter HPK19_RS19205 ENOG4108TYN CAAX amino terminal protease family protein HPK19_RS19210 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HPK19_RS19215 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HPK19_RS19225 ENOG4105VTR Integrase HPK19_RS19230 ENOG41067QW Transcriptional regulator HPK19_RS19250 ENOG4108ZUE Phage regulatory protein rha HPK19_RS19300 ENOG4105QBX endodeoxyribonuclease RusA HPK19_RS19350 ENOG4105CAR Terminase, large subunit HPK19_RS19420 ENOG4108FKH Transglycosylase SLT domain HPK19_RS19450 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HPK19_RS19510 ENOG4105DR5 peptidase HPK19_RS19535 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HPK19_RS19540 ENOG41080TC multidrug resistance protein HPK19_RS19570 ENOG4105C7N Xanthine uracil vitamin C permease HPK19_RS19610 ENOG4105C98 muts2 protein HPK19_RS19615 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HPK19_RS19630 ENOG4105CK1 PTS System HPK19_RS19635 ENOG4105VZJ PTS System HPK19_RS19640 ENOG4105VCP PTS System HPK19_RS19645 ENOG4105EMD TRANSCRIPTIONal HPK19_RS19725 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HPK19_RS19730 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HPK19_RS19735 ENOG4105C83 adenylosuccinate lyase HPK19_RS19740 ENOG4105C8V SAICAR synthetase HPK19_RS19745 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HPK19_RS19750 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HPK19_RS19765 ENOG4105CXB phosphoribosylaminoimidazole synthetase HPK19_RS19770 ENOG4108V3E phosphoribosylglycinamide formyltransferase HPK19_RS19780 ENOG4105C12 Phosphoribosylglycinamide synthetase HPK19_RS19790 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) HPK19_RS19795 ENOG4105C4R Atp-dependent dna helicase HPK19_RS19810 ENOG4105C26 Dehydrogenase HPK19_RS19820 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HPK19_RS19830 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HPK19_RS19835 ENOG4108QTI )-transporter HPK19_RS19840 ENOG4105CBD Diacylglycerol kinase HPK19_RS19845 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HPK19_RS19870 ENOG4108SU4 UPF0309 protein HPK19_RS19885 ENOG4105CK1 PTS System HPK19_RS19895 ENOG4105VZJ PTS System HPK19_RS19900 ENOG4105VCP PTS System HPK19_RS19905 ENOG4105F8D glycoside hydrolase family 4 HPK19_RS19915 ENOG4105CUB amino acid HPK19_RS19920 ENOG4108WMK Efflux transporter RND family MFP subunit HPK19_RS19935 ENOG4107HP6 Transcriptional regulator HPK19_RS19950 ENOG4105CHR reductase HPK19_RS19955 ENOG4105C7K acetolactate synthase HPK19_RS19965 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) HPK19_RS19970 ENOG4105FUY alpha subunit HPK19_RS19980 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase HPK19_RS19995 ENOG4105EWU Squalene--hopene cyclase HPK19_RS20000 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPK19_RS20015 ENOG4107S4Y M20 DapE family protein YgeY HPK19_RS20020 ENOG4108TSC N-acetyltransferase HPK19_RS20025 ENOG4108JUB Transcriptional regulator HPK19_RS20030 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HPK19_RS20040 ENOG4108IQI permease HPK19_RS20050 ENOG4105CID antiterminator HPK19_RS20055 ENOG4105C5Y PTS System HPK19_RS20070 ENOG4105CUB amino acid HPK19_RS20075 ENOG4105D82 Glutamate dehydrogenase HPK19_RS20090 ENOG4108JUB Transcriptional regulator HPK19_RS20105 ENOG4108JPW Aminotransferase HPK19_RS20110 ENOG4105C26 Dehydrogenase HPK19_RS20115 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPK19_RS20120 ENOG4105C1G acyl-Coa dehydrogenase HPK19_RS20150 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPK19_RS20155 ENOG4105C4M (Ubiquinol oxidase) subunit I HPK19_RS20170 ENOG4105E0A ABC, transporter HPK19_RS20180 ENOG4105DQ5 transport system permease protein HPK19_RS20185 ENOG4105EHG Permease protein HPK19_RS20190 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HPK19_RS20195 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HPK19_RS20235 ENOG4108VXD carboxy-peptidase HPK19_RS20245 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS20250 ENOG4105EXC Acyl-transferase HPK19_RS20255 ENOG4108P49 AntiSigma factor HPK19_RS20260 ENOG4105JVQ RNA Polymerase HPK19_RS20270 ENOG41068WN HPK19_RS20275 ENOG4107T94 Endo-14-beta-xylanase HPK19_RS20290 ENOG4107QJQ Mate efflux family protein HPK19_RS20305 ENOG4105CDA abc transporter atp-binding protein HPK19_RS20310 ENOG4105E5Q amino acid AbC transporter HPK19_RS20315 ENOG4107R0W ABC transporter HPK19_RS20330 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HPK19_RS20340 ENOG4105BZU Histidine kinase HPK19_RS20345 ENOG4105DIN metallophosphoesterase HPK19_RS20380 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HPK19_RS20390 ENOG4105CQC Prephenate dehydratase HPK19_RS20400 ENOG4108JUB Transcriptional regulator HPK19_RS20405 ENOG4105C8Y Acetylornithine aminotransferase HPK19_RS20410 ENOG4105D82 Glutamate dehydrogenase HPK19_RS20415 ENOG4108IQI permease HPK19_RS20425 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPK19_RS20430 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPK19_RS20435 ENOG4108JQ7 (ABC) transporter HPK19_RS20445 ENOG4108WPJ Ferritin-like domain HPK19_RS20455 ENOG4105N67 Proton-coupled thiamine transporter YuaJ HPK19_RS20460 ENOG4105KJF protein tyrosine phosphatase HPK19_RS20470 ENOG4107U9T Pfam:Ribonuclease_BN HPK19_RS20475 ENOG4105C59 p-type ATPase HPK19_RS20485 ENOG4108IPJ Membrane HPK19_RS20505 ENOG4105K4H Nlp p60 protein HPK19_RS20510 ENOG4105KAF membrAne HPK19_RS20520 ENOG4105KAF membrAne HPK19_RS20575 ENOG4105C2F Histidine kinase HPK19_RS20580 ENOG4105EQD regulatoR HPK19_RS20585 ENOG4105CRN Aminoglycoside phosphotransferase HPK19_RS20595 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPK19_RS20605 ENOG4105HTX biosynthesis protein HPK19_RS20610 ENOG4107YJ4 chain length determinant protein HPK19_RS20620 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HPK19_RS20625 ENOG4105D3Q Sugar transferase HPK19_RS20645 ENOG4105K64 Glycosyl transferase, family 2 HPK19_RS20660 ENOG4105CPK Glycosyl transferase (Group 1 HPK19_RS20670 ENOG4108KGH TRANSCRIPTIONal HPK19_RS20680 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HPK19_RS20720 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HPK19_RS20725 ENOG4105CMR udp-glucose 4-epimerase HPK19_RS20730 ENOG4105CMR udp-glucose 4-epimerase HPK19_RS20735 ENOG4107VDP teichoic acid biosynthesis HPK19_RS20745 ENOG4107VDP teichoic acid biosynthesis HPK19_RS20765 ENOG4107VDP teichoic acid biosynthesis HPK19_RS20780 ENOG4105EY8 ABC transporter HPK19_RS20785 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HPK19_RS20800 ENOG410606W general stress protein HPK19_RS20805 ENOG4105UPD Calcium Proton HPK19_RS20855 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HPK19_RS20885 ENOG4105CVA phosphate HPK19_RS20895 ENOG4105CVA phosphate HPK19_RS20900 ENOG4105C8U phosphate abc transporter HPK19_RS20905 ENOG4105E2Z phosphate ABC transporter (Permease HPK19_RS20925 ENOG4105BZU Histidine kinase HPK19_RS20930 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPK19_RS20935 ENOG4105EDW glycosyl transferase, family 39 HPK19_RS20940 ENOG4105CKK Glycosyl transferase, family 2 HPK19_RS20950 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HPK19_RS20955 ENOG4105CMR udp-glucose 4-epimerase HPK19_RS20965 ENOG4105BZ1 (ABC) transporter HPK19_RS20970 ENOG4105BZ1 (ABC) transporter HPK19_RS20975 ENOG4105ETS cytosine purines uracil thiamine allantoin HPK19_RS20985 ENOG4105C2F Histidine kinase HPK19_RS20990 ENOG4108VAC response regulator HPK19_RS21005 ENOG4108HWW ABC transporter HPK19_RS21035 ENOG4105DNP FAD linked oxidase domain protein HPK19_RS21040 ENOG4105E66 phosphoriboisomerase A HPK19_RS21045 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HPK19_RS21070 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HPK19_RS21090 ENOG4108S4H thioesterase Superfamily protein HPK19_RS21100 ENOG4105CNG UPF0061 protein HPK19_RS21105 ENOG4108IPJ Membrane HPK19_RS21135 ENOG4105MSI germination protein ypeb HPK19_RS21145 ENOG4105VZJ PTS System HPK19_RS21150 ENOG4105CK1 PTS System HPK19_RS21155 ENOG4105VCP PTS System HPK19_RS21160 ENOG4105F8D glycoside hydrolase family 4 HPK19_RS21185 ENOG4105BZ1 (ABC) transporter HPK19_RS21200 ENOG410645S MarR family Transcriptional regulator HPK19_RS21205 ENOG4107TS3 membrane protein, TerC HPK19_RS21220 ENOG4105X5K response regulator receiver protein HPK19_RS21265 ENOG4105F8D glycoside hydrolase family 4 HPK19_RS21270 ENOG4105VCP PTS System HPK19_RS21275 ENOG4105RD7 BadF BadG BcrA BcrD HPK19_RS21290 ENOG4105VEQ Cold shock protein HPK19_RS21300 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HPK19_RS21305 ENOG4105CQB FAD linked oxidase domain protein HPK19_RS21320 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPK19_RS21325 ENOG4105C87 Aminotransferase class I and II HPK19_RS21330 ENOG4105CI1 PTS System HPK19_RS21335 ENOG4106KNT transcriptional regulator HPK19_RS21360 ENOG4106KNT transcriptional regulator HPK19_RS21380 ENOG4105C5W Aldolase HPK19_RS21390 ENOG4105C71 hydrolase family 65, central catalytic HPK19_RS21395 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HPK19_RS21405 ENOG4108R5T secreted protein HPK19_RS21410 ENOG4105DDN Pentapeptide repeat-containing protein HPK19_RS21425 ENOG4105FDR Membrane HPK19_RS21445 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS21450 ENOG4105C1J atp-dependent rna helicase HPK19_RS21455 ENOG4105CSV Glutaminase HPK19_RS21470 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPK19_RS21475 ENOG4105C02 permease HPK19_RS21480 ENOG4105E0M Sulfatase HPK19_RS21485 ENOG4107T89 von Willebrand factor, type A HPK19_RS21490 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HPK19_RS21500 ENOG4105F1A Pyruvate formate-lyase HPK19_RS21520 ENOG4105CI2 imidazolone-5-propionate hydrolase HPK19_RS21525 ENOG4105ECP epimerase HPK19_RS21550 ENOG41067AE Membrane-bound metal-dependent hydrolase HPK19_RS21555 ENOG4105CEN a g-specific adenine glycosylase HPK19_RS21560 ENOG4106BXE HPK19_RS21575 ENOG4105EVI UPF0374 protein HPK19_RS21580 ENOG4105BZ1 (ABC) transporter HPK19_RS21585 ENOG4107NBY Membrane HPK19_RS21590 ENOG4105CBC glutamate synthase HPK19_RS21600 ENOG4108IUW ABC transporter HPK19_RS21620 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPK19_RS21625 ENOG4105G5W regulator Fur family HPK19_RS21630 ENOG4105TUA UPF0295 protein HPK19_RS21795 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HPK19_RS21815 ENOG4105VEQ Cold shock protein HPK19_RS21820 ENOG4108606 TspO/MBR family HPK19_RS21830 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HPK19_RS21835 ENOG4105E4F Isochorismate synthase HPK19_RS21840 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HPK19_RS21845 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HPK19_RS21850 ENOG4108IPT Naphthoate synthase HPK19_RS21860 ENOG4105DTQ mandelate racemase muconate lactonizing HPK19_RS21865 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HPK19_RS21880 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HPK19_RS21890 ENOG4105D2X ABC transporter substrate-binding protein HPK19_RS21895 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HPK19_RS21900 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HPK19_RS21910 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HPK19_RS21955 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HPK19_RS21965 ENOG4108UKZ OsmC family HPK19_RS21975 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HPK19_RS21985 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HPK19_RS21990 ENOG4105BZF Glycosyl transferase (Group 1 HPK19_RS21995 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HPK19_RS22000 ENOG4108Z0R Transferase HPK19_RS22010 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPK19_RS22015 ENOG4107RWR Sodium hydrogen exchanger HPK19_RS22030 ENOG4105N5T Radical SAM Protein HPK19_RS22045 ENOG410605W Major Facilitator HPK19_RS22055 ENOG41085GJ domain protein HPK19_RS22065 ENOG4105CBX hi0933 family HPK19_RS22080 ENOG4105YW5 deoR family transcriptional regulator HPK19_RS22085 ENOG4107QSE Dipeptidase HPK19_RS22100 ENOG4108IUM Glycogen debranching enzyme HPK19_RS22105 ENOG4108V15 phosphotransferase enzyme family HPK19_RS22120 ENOG41089UC methyltransferase, type 11 HPK19_RS22130 ENOG4105C8F Beta-lactamase domain protein HPK19_RS22155 ENOG4108NKM UPF0354 protein HPK19_RS22160 ENOG4108VDD TRNA binding domain protein HPK19_RS22185 ENOG4105C54 Major Facilitator superfamily HPK19_RS22190 ENOG4105C84 Histidine ammonia-lyase HPK19_RS22195 ENOG41063TF transcriptional regulator (AraC HPK19_RS22225 ENOG4105FDF Could be involved in DNA repair (By similarity) HPK19_RS22230 ENOG4108J9Q DNA ligase HPK19_RS22235 ENOG4105DQE DNA ligase HPK19_RS22240 ENOG4105CN5 Metallo-Beta-Lactamase HPK19_RS22255 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS22265 ENOG4105EMN RNA polymerase sigma factor HPK19_RS22270 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HPK19_RS22275 ENOG4105EKQ RNA-directed DNA polymerase HPK19_RS22300 ENOG4105I4A GCN5-related N-acetyltransferase HPK19_RS22310 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HPK19_RS22320 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HPK19_RS22325 ENOG4105KTU Transcriptional regulator, arsr family HPK19_RS22345 ENOG4105D29 Helix-turn-helix type 11 domain protein HPK19_RS22370 ENOG41086D8 Transcriptional regulator HPK19_RS22400 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HPK19_RS22410 ENOG4105C3M thioredoxin reductase HPK19_RS22435 ENOG4105JAB phenazine biosynthesis protein, phzf family HPK19_RS22440 ENOG4107TVP HD domain protein HPK19_RS22450 ENOG4105DFD Na H antiporter HPK19_RS22470 ENOG4105G3Z GntR family transcriptional regulator HPK19_RS22475 ENOG4105CMG Carbohydrate kinase HPK19_RS22485 ENOG4105C88 aminopeptidase HPK19_RS22500 ENOG4105KHC sulfurtransferase HPK19_RS22515 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HPK19_RS22520 ENOG4105ETE Transcriptional regulator (LacI family HPK19_RS22525 ENOG4105DGU Histone deacetylase HPK19_RS22530 ENOG4105W87 Cbs domain HPK19_RS22535 ENOG4105F1V Acetoin utilization protein HPK19_RS22550 ENOG4108V0P LemA family HPK19_RS22565 ENOG4105DFD Na H antiporter HPK19_RS22580 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HPK19_RS22590 ENOG4105U5Y Transcriptional regulator HPK19_RS22595 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) HPK19_RS22610 ENOG4105YWU small acid-soluble spore protein HPK19_RS22620 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HPK19_RS22625 ENOG4105EFZ amidohydrolase HPK19_RS22635 ENOG4105KBJ sporulation protein ytfj HPK19_RS22640 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HPK19_RS22645 ENOG4105II7 pyrroline-5-carboxylate reductase HPK19_RS22650 ENOG4105FF5 Membrane HPK19_RS22655 ENOG4107R8N Glycosyl transferase, family 2 HPK19_RS22670 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HPK19_RS22675 ENOG4105EU9 HPK19_RS22700 ENOG4105DC7 peptidase M24 HPK19_RS22725 ENOG4105SFS phosphoesterase RecJ domain protein HPK19_RS22735 ENOG4105VV2 HPK19_RS22740 ENOG4105C0B DNA polymerase III (alpha subunit) HPK19_RS22745 ENOG4105C6K Malic enzyme HPK19_RS22755 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HPK19_RS22760 ENOG4105CTQ phosphohexokinase HPK19_RS22780 ENOG4108REF Sporulation integral membrane protein ytvi HPK19_RS22790 ENOG4105BZN citrate synthase HPK19_RS22795 ENOG4108HMX isocitrate dehydrogenase (NADP) HPK19_RS22800 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HPK19_RS22815 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPK19_RS22820 ENOG4105BZU Histidine kinase HPK19_RS22830 ENOG4105C2M dna polymerase I HPK19_RS22850 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HPK19_RS22855 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HPK19_RS22860 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HPK19_RS22875 ENOG4108TDW sporulation protein YtxC HPK19_RS22880 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HPK19_RS22890 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HPK19_RS22905 ENOG4105CN9 Peptidase m42 family protein HPK19_RS22910 ENOG4108IJ7 Glycine betaine HPK19_RS22925 ENOG4108RWN rrna methyltransferase HPK19_RS22930 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HPK19_RS22955 ENOG4107S6X Glycosyl transferase, family 2 HPK19_RS22960 ENOG4107TVC Glycosyl transferase, family 2 HPK19_RS22965 ENOG4107TVC Glycosyl transferase, family 2 HPK19_RS22970 ENOG4105C75 arginyL-tRNA synthetase HPK19_RS22975 ENOG4107Y03 Nitroreductase HPK19_RS22980 ENOG4105C5H ABC transporter HPK19_RS22990 ENOG4108QCI YvbH-like oligomerisation region HPK19_RS23025 ENOG4105DCG PHP domain protein HPK19_RS23040 ENOG4108W0I acetyltransferase HPK19_RS23070 ENOG4108IUX (ABC) transporter HPK19_RS23075 ENOG4105RHA ABC transporter, permease HPK19_RS23095 ENOG4105CEY Amp-dependent synthetase and ligase HPK19_RS23100 ENOG4107Z3H Transcriptional regulator, TetR family HPK19_RS23105 ENOG41060WC Enoyl-CoA hydratase HPK19_RS23110 ENOG4105BZJ Electron transfer flavoprotein HPK19_RS23115 ENOG4105C10 Electron transfer flavoprotein HPK19_RS23135 ENOG4105K63 Thioredoxin HPK19_RS23140 ENOG41067TZ transcriptional regulator, MarR family HPK19_RS23145 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPK19_RS23175 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HPK19_RS23185 ENOG4105E33 succinate dehydrogenase HPK19_RS23210 ENOG4105C22 threonyL-tRNA synthetase HPK19_RS23230 ENOG4105KPV Transcriptional regulator HPK19_RS23240 ENOG4105D2X ABC transporter substrate-binding protein HPK19_RS23250 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HPK19_RS23260 ENOG4108RE7 deoxyribonuclease HPK19_RS23265 ENOG4105PFC Transcriptional regulator HPK19_RS23270 ENOG4108XJQ germination protein HPK19_RS23280 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HPK19_RS23285 ENOG4105M59 Phosphodiesterase, mj0936 family HPK19_RS23310 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HPK19_RS23320 ENOG4108IUQ atp-dependent protease HPK19_RS23340 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HPK19_RS23360 ENOG4105D52 delta-aminolevulinic acid dehydratase HPK19_RS23365 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HPK19_RS23370 ENOG41068KH stage VI sporulation protein D HPK19_RS23370 ENOG41068KH stage VI sporulation protein D HPK19_RS23375 ENOG4106AR7 Spore coat protein HPK19_RS23380 ENOG4108N23 SpoOM-related protein HPK19_RS23385 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HPK19_RS23390 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HPK19_RS23395 ENOG4105BZU Histidine kinase HPK19_RS23415 ENOG4105DFF Rod shape-determining protein mreb HPK19_RS23420 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HPK19_RS23425 ENOG4105YHC Rod shape-determining protein MreD HPK19_RS23430 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HPK19_RS23435 ENOG4107QMS site-determining protein HPK19_RS23450 ENOG4108RJ9 Glycosyl transferase, family 2 HPK19_RS23455 ENOG4105C03 ribonuclease HPK19_RS23460 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HPK19_RS23465 ENOG4105X36 (ribosomal) protein HPK19_RS23470 ENOG4105K46 50S ribosomal protein l27 HPK19_RS23495 ENOG4108IYU L-aspartate oxidase HPK19_RS23500 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HPK19_RS23535 ENOG4105CPC Aldo Keto reductase HPK19_RS23550 ENOG4107S9D Alpha beta hydrolase HPK19_RS23590 ENOG41068WN HPK19_RS23605 ENOG41061AI Protein of unknown function (DUF2905) HPK19_RS23610 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HPK19_RS23620 ENOG4105VIE preprotein translocase, subunit YajC HPK19_RS23625 ENOG4105NAP HPK19_RS23630 ENOG4108QG2 Membrane HPK19_RS23635 ENOG4105CKP Polysaccharide Biosynthesis Protein HPK19_RS23645 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPK19_RS23650 ENOG41076HS cation diffusion facilitator family transporter HPK19_RS23655 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HPK19_RS23660 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HPK19_RS23665 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HPK19_RS23690 ENOG4105C9M aspartyl-trna synthetase HPK19_RS23695 ENOG4105CUZ uba thif-type nad fad binding protein HPK19_RS23715 ENOG4105D1H recombination factor protein RarA HPK19_RS23740 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS23750 ENOG4105C3J Cysteine desulfurase HPK19_RS23755 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HPK19_RS23765 ENOG4105C7H Helicase, RecD TraA family HPK19_RS23770 ENOG41060CR HPK19_RS23780 ENOG4105C02 permease HPK19_RS23785 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HPK19_RS23790 ENOG4105VBH UPF0297 protein HPK19_RS23795 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HPK19_RS23800 ENOG4105VPH UPF0473 protein HPK19_RS23805 ENOG4105HHA aminodeoxychorismate lyase HPK19_RS23815 ENOG4105XYU peptidase (U32 family) HPK19_RS23820 ENOG4105CFP Peptidase U32 HPK19_RS23835 ENOG4107XRG penicillin-binding protein HPK19_RS23850 ENOG4105CJ1 ABC, transporter HPK19_RS23855 ENOG41090VJ ABC-2 type transporter HPK19_RS23860 ENOG41067SE Tetr family transcriptional regulator HPK19_RS23870 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPK19_RS23875 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HPK19_RS23900 ENOG4105WMR Protein CrcB homolog HPK19_RS23905 ENOG4105WMR Protein CrcB homolog HPK19_RS23930 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HPK19_RS23935 ENOG4105CQW ribosome biogenesis GTPase YqeH HPK19_RS23945 ENOG410812S Rna-binding protein HPK19_RS23950 ENOG4108WF2 Metal Dependent Phosphohydrolase HPK19_RS23960 ENOG4105DXX methyltransferase HPK19_RS23975 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HPK19_RS23985 ENOG4105TQK DNA polymerase iii, delta' subunit HPK19_RS23995 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HPK19_RS24010 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HPK19_RS24015 ENOG4105CSA Coproporphyrinogen iii oxidase HPK19_RS24025 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HPK19_RS24030 ENOG4105CFG Acts as a chaperone (By similarity) HPK19_RS24040 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HPK19_RS24045 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HPK19_RS24050 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HPK19_RS24080 ENOG41075H3 AraC family transcriptional regulator HPK19_RS24085 ENOG4105C2F Histidine kinase HPK19_RS24090 ENOG4108JQ7 (ABC) transporter HPK19_RS24105 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPK19_RS24110 ENOG4105DEF Extracellular solute-binding protein, family 5 HPK19_RS24115 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HPK19_RS24120 ENOG4105CI2 imidazolone-5-propionate hydrolase HPK19_RS24130 ENOG4105DZC cytosine deaminase HPK19_RS24135 ENOG4105DZC cytosine deaminase HPK19_RS24140 ENOG4105DZC cytosine deaminase HPK19_RS24150 ENOG4105DTE Xanthine uracil vitamin C permease HPK19_RS24155 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HPK19_RS24180 ENOG4108UB7 HPK19_RS24200 ENOG4105CZM Major Facilitator HPK19_RS24205 ENOG4107MII Sugar-specific transcriptional regulator TrmB HPK19_RS24210 ENOG4108JYZ YitT family HPK19_RS24275 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS24295 ENOG4105ECQ AraC Family Transcriptional Regulator HPK19_RS24315 ENOG4105CGP Urocanate hydratase HPK19_RS24320 ENOG4105CI2 imidazolone-5-propionate hydrolase HPK19_RS24330 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS24335 ENOG4105NPE arsR family transcriptional regulator HPK19_RS24345 ENOG4105K56 Transcriptional regulator HPK19_RS24360 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS24365 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS24375 ENOG4107R6U sodium dicarboxylate symporter HPK19_RS24385 ENOG4105G9B Transcriptional regulator HPK19_RS24390 ENOG4105DJB Major Facilitator Superfamily HPK19_RS24395 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HPK19_RS24400 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS24410 ENOG4107TXC Transcriptional regulator HPK19_RS24415 ENOG41076HS cation diffusion facilitator family transporter HPK19_RS24455 ENOG4105YWU small acid-soluble spore protein HPK19_RS24460 ENOG4105KRN Transcriptional regulator, abrb family HPK19_RS24470 ENOG4105W1Y Transcriptional regulator HPK19_RS24510 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HPK19_RS24520 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) HPK19_RS24525 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HPK19_RS24595 ENOG4105EKQ RNA-directed DNA polymerase HPK19_RS24625 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS24630 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS24635 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS24640 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS24660 ENOG4105EKQ RNA-directed DNA polymerase HPK19_RS24685 ENOG41062MS nucleotidyltransferase substrate binding protein HPK19_RS24710 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPK19_RS24715 ENOG4105C5F glutamine synthetase HPK19_RS24725 ENOG4105CUB amino acid HPK19_RS24755 ENOG4105XN3 extracellular solute-binding protein family 1 HPK19_RS24760 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HPK19_RS24765 ENOG4105ID8 Transcriptional regulator, ARAC family HPK19_RS24770 ENOG4105DG6 mannose-6-phosphate isomerase HPK19_RS24785 ENOG4107QM2 Aldo Keto reductase HPK19_RS24795 ENOG4108Q8B Spore germination protein HPK19_RS24810 ENOG4105DQ6 Transposase HPK19_RS24880 ENOG4105K4H Nlp p60 protein HPK19_RS24975 ENOG4107RVG penicillin-binding protein HPK19_RS24985 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS24990 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS25060 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPK19_RS25080 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPK19_RS25130 ENOG4105EKQ RNA-directed DNA polymerase HPK19_RS25165 ENOG4105DCI Phosphohydrolase HPK19_RS25210 ENOG4105VMP Transcriptional regulator HPK19_RS25215 ENOG4105VRS hydrolase family 18 HPK19_RS25250 ENOG4105YWU small acid-soluble spore protein HPK19_RS25260 ENOG4105CNU cell division protein FtsK HPK19_RS25315 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS25325 ENOG4105CHH sulfate transporter HPK19_RS25330 ENOG4108V2W Carbonate dehydratase HPK19_RS25365 ENOG4108Q8B Spore germination protein HPK19_RS25380 ENOG41062IR nudix hydrolase HPK19_RS25420 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS25445 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS25470 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPK19_RS25490 ENOG4105K70 DNA-binding protein HPK19_RS25540 ENOG4105W5Q DNA repair protein (RadC HPK19_RS25555 ENOG4105C2C drug resistance transporter, Bcr CflA HPK19_RS25560 ENOG4105K56 Transcriptional regulator HPK19_RS25575 ENOG4108DBC nitroreductase HPK19_RS25585 ENOG4107RBB ABC transporter, permease HPK19_RS25590 ENOG4105C19 ABC transporter HPK19_RS25630 ENOG4105E2D ec 3.2.1.52 HPK19_RS25640 ENOG4105WH1 Two component transcriptional regulator luxr family HPK19_RS25645 ENOG4105BZU Histidine kinase