locus-tag	class	description
HPK19_RS00010	COG0667	Aldo Keto reductase
HPK19_RS00020	COG1942	4-Oxalocrotonate Tautomerase
HPK19_RS00030	COG0583	DNA-binding transcription factor activity
HPK19_RS00035	COG4122	O-methyltransferase activity
HPK19_RS00055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPK19_RS00085	COG0456	acetyltransferase
HPK19_RS00105	COG1131	(ABC) transporter
HPK19_RS00115	COG1376	ErfK ybiS ycfS ynhG family protein
HPK19_RS00135	COG3069	C4-dicarboxylate transmembrane transporter activity
HPK19_RS00140	COG0494	nUDIX hydrolase
HPK19_RS00145	COG1792	Involved in formation and maintenance of cell shape
HPK19_RS00150	COG0784	Response regulator, receiver
HPK19_RS00150	COG2205	protein histidine kinase activity
HPK19_RS00190	COG0494	nUDIX hydrolase
HPK19_RS00210	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HPK19_RS00245	COG1404	Belongs to the peptidase S8 family
HPK19_RS00265	COG2333	competence protein COMEC
HPK19_RS00265	COG0658	competence protein
HPK19_RS00290	COG1131	(ABC) transporter
HPK19_RS00300	COG0765	amino acid transport
HPK19_RS00305	COG0765	amino acid transport
HPK19_RS00310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK19_RS00315	COG1126	abc transporter atp-binding protein
HPK19_RS00330	COG1404	Belongs to the peptidase S8 family
HPK19_RS00390	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_RS00415	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HPK19_RS00420	COG1263	PTS System
HPK19_RS00420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK19_RS00430	COG1737	Transcriptional regulator
HPK19_RS00465	COG0395	ABC-type sugar transport system, permease component
HPK19_RS00475	COG0673	inositol 2-dehydrogenase activity
HPK19_RS00480	COG1082	Xylose isomerase domain protein TIM barrel
HPK19_RS00490	COG3962	Belongs to the TPP enzyme family
HPK19_RS00495	COG3718	enzyme involved in inositol metabolism
HPK19_RS00500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK19_RS00505	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_RS00510	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPK19_RS00515	COG2723	6-phospho-beta-galactosidase activity
HPK19_RS00520	COG1414	Transcriptional regulator
HPK19_RS00525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK19_RS00530	COG0800	Aldolase
HPK19_RS00535	COG4948	Mandelate Racemase Muconate Lactonizing
HPK19_RS00540	COG2271	Major facilitator Superfamily
HPK19_RS00555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK19_RS00560	COG4209	transmembrane transport
HPK19_RS00565	COG0395	ABC-type sugar transport system, permease component
HPK19_RS00605	COG1131	(ABC) transporter
HPK19_RS00610	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPK19_RS00635	COG5001	Diguanylate cyclase
HPK19_RS00635	COG3706	GGDEF domain
HPK19_RS00635	COG2203	Gaf domain
HPK19_RS00635	COG4251	negative regulation of phosphorylation
HPK19_RS00645	COG0791	NLP P60 protein
HPK19_RS00645	COG1388	LysM domain
HPK19_RS00660	COG3584	3D domain protein
HPK19_RS00660	COG1388	LysM domain
HPK19_RS00670	COG3383	formate dehydrogenase (NAD+) activity
HPK19_RS00675	COG2427	Protein of unknown function (DUF1641)
HPK19_RS00680	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPK19_RS00690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPK19_RS00695	COG0303	'Molybdopterin
HPK19_RS00700	COG0314	molybdopterin synthase activity
HPK19_RS00705	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPK19_RS00715	COG0746	molybdenum cofactor guanylyltransferase activity
HPK19_RS00725	COG5609	conserved protein (DUF2294)
HPK19_RS00730	COG1763	Mo-molybdopterin cofactor biosynthetic process
HPK19_RS00735	COG4149	molybdate abc transporter
HPK19_RS00740	COG2258	MOSC domain
HPK19_RS00760	COG1073	alpha beta
HPK19_RS00785	COG1653	transport
HPK19_RS00790	COG1175	transmembrane transport
HPK19_RS00795	COG0395	ABC-type sugar transport system, permease component
HPK19_RS00800	COG0366	Alpha amylase catalytic
HPK19_RS00810	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HPK19_RS00820	COG1940	carbohydrate kinase activity
HPK19_RS00825	COG1482	cell wall glycoprotein biosynthetic process
HPK19_RS00855	COG1794	racemase activity, acting on amino acids and derivatives
HPK19_RS00865	COG4585	Histidine kinase
HPK19_RS00870	COG2197	response regulator
HPK19_RS00880	COG1011	Hydrolase
HPK19_RS00890	COG1396	sequence-specific DNA binding
HPK19_RS00910	COG2267	carboxylic ester hydrolase activity
HPK19_RS00915	COG1472	Belongs to the glycosyl hydrolase 3 family
HPK19_RS00945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPK19_RS00955	COG1959	2 iron, 2 sulfur cluster binding
HPK19_RS00965	COG2514	catechol 2,3-dioxygenase activity
HPK19_RS00975	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HPK19_RS01025	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPK19_RS01035	COG1610	YqeY-like protein
HPK19_RS01050	COG1702	phosphate starvation-inducible protein PhoH
HPK19_RS01055	COG1480	7TM receptor with intracellular HD hydrolase
HPK19_RS01060	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPK19_RS01065	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPK19_RS01070	COG0295	cytidine deaminase activity
HPK19_RS01075	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPK19_RS01085	COG1381	Involved in DNA repair and RecF pathway recombination
HPK19_RS01090	COG0517	IMP dehydrogenase activity
HPK19_RS01095	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPK19_RS01100	COG0358	DNA primase activity
HPK19_RS01105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPK19_RS01110	COG2010	Cytochrome c
HPK19_RS01115	COG2384	SAM-dependent methyltransferase
HPK19_RS01120	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPK19_RS01125	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPK19_RS01140	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPK19_RS01165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPK19_RS01170	COG1121	(ABC) transporter
HPK19_RS01175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPK19_RS01180	COG0735	belongs to the Fur family
HPK19_RS01190	COG0300	oxidoreductase activity
HPK19_RS01205	COG4187	Peptidase family M20/M25/M40
HPK19_RS01220	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HPK19_RS01230	COG4208	sulfate ABC transporter
HPK19_RS01240	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPK19_RS01270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPK19_RS01280	COG0477	Major facilitator Superfamily
HPK19_RS01295	COG0704	Plays a role in the regulation of phosphate uptake
HPK19_RS01305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPK19_RS01310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPK19_RS01320	COG1876	peptidase activity
HPK19_RS01330	COG1940	carbohydrate kinase activity
HPK19_RS01335	COG1368	sulfuric ester hydrolase activity
HPK19_RS01350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_RS01365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPK19_RS01370	COG1459	type II secretion system
HPK19_RS01375	COG4537	Required for transformation and DNA binding
HPK19_RS01400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPK19_RS01415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPK19_RS01420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPK19_RS01425	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPK19_RS01435	COG1525	nuclease
HPK19_RS01435	COG4085	toxin activity
HPK19_RS01435	COG0737	Belongs to the 5'-nucleotidase family
HPK19_RS01445	COG0745	RESPONSE REGULATOR receiver
HPK19_RS01450	COG5002	protein histidine kinase activity
HPK19_RS01455	COG0527	aspartate kinase activity
HPK19_RS01460	COG1522	sequence-specific DNA binding
HPK19_RS01465	COG0436	Aminotransferase
HPK19_RS01485	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPK19_RS01490	COG0529	Catalyzes the synthesis of activated sulfate
HPK19_RS01495	COG2046	Belongs to the sulfate adenylyltransferase family
HPK19_RS01500	COG0175	sulfate reduction
HPK19_RS01510	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HPK19_RS01515	COG2409	Drug exporters of the RND superfamily
HPK19_RS01520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPK19_RS01525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK19_RS01530	COG0095	Lipoate-protein ligase
HPK19_RS01550	COG3872	metal-dependent enzyme
HPK19_RS01560	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPK19_RS01565	COG0006	proline dipeptidase activity
HPK19_RS01570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPK19_RS01585	COG3854	ATPases associated with a variety of cellular activities
HPK19_RS01625	COG0511	ligase activity, forming carbon-carbon bonds
HPK19_RS01630	COG0439	Biotin carboxylase
HPK19_RS01635	COG1302	Protein conserved in bacteria
HPK19_RS01640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK19_RS01645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPK19_RS01650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPK19_RS01655	COG1570	exodeoxyribonuclease VII activity
HPK19_RS01660	COG1722	exodeoxyribonuclease VII activity
HPK19_RS01670	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPK19_RS01675	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HPK19_RS01680	COG1438	arginine binding
HPK19_RS01685	COG0497	DNA recombination
HPK19_RS01690	COG0750	zinc metalloprotease
HPK19_RS01695	COG0745	RESPONSE REGULATOR receiver
HPK19_RS01705	COG3093	addiction module antidote protein HigA
HPK19_RS01710	COG0584	glycerophosphoryl diester phosphodiesterase
HPK19_RS01720	COG3290	protein histidine kinase activity
HPK19_RS01720	COG3829	transcription factor binding
HPK19_RS01725	COG0280	phosphate acetyltransferase
HPK19_RS01735	COG3426	butyrate kinase activity
HPK19_RS01740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPK19_RS01745	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPK19_RS01750	COG0022	dehydrogenase e1 component
HPK19_RS01755	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPK19_RS01765	COG2211	Major facilitator Superfamily
HPK19_RS01790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK19_RS01800	COG0765	amino acid transport
HPK19_RS01805	COG1126	abc transporter atp-binding protein
HPK19_RS01810	COG1607	acyl-coa hydrolase
HPK19_RS01815	COG4129	membrane
HPK19_RS01820	COG1376	ErfK ybiS ycfS ynhG family protein
HPK19_RS01830	COG0346	lactoylglutathione lyase activity
HPK19_RS01835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HPK19_RS01840	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPK19_RS01845	COG0586	Pfam SNARE associated Golgi protein
HPK19_RS01865	COG3011	Protein conserved in bacteria
HPK19_RS01870	COG2346	COG2346, Truncated hemoglobins
HPK19_RS01890	COG0405	Gamma-glutamyltransferase
HPK19_RS01895	COG2059	Chromate
HPK19_RS01900	COG2059	Chromate
HPK19_RS01915	COG0789	Transcriptional regulator
HPK19_RS01920	COG0492	ferredoxin-NADP+ reductase activity
HPK19_RS01925	COG0697	spore germination
HPK19_RS01930	COG3708	Transcriptional regulator
HPK19_RS01930	COG2207	Transcriptional regulator
HPK19_RS01935	COG0673	inositol 2-dehydrogenase activity
HPK19_RS01945	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HPK19_RS01960	COG1234	tRNA 3'-trailer cleavage
HPK19_RS01995	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPK19_RS02000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_RS02005	COG0300	oxidoreductase activity
HPK19_RS02015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPK19_RS02035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPK19_RS02040	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPK19_RS02045	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPK19_RS02050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPK19_RS02055	COG0748	coenzyme F420 binding
HPK19_RS02085	COG4948	Mandelate Racemase Muconate Lactonizing
HPK19_RS02090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPK19_RS02095	COG0747	negative chemotaxis
HPK19_RS02110	COG0444	Belongs to the ABC transporter superfamily
HPK19_RS02115	COG4608	Belongs to the ABC transporter superfamily
HPK19_RS02120	COG0823	Involved in the tonB-independent uptake of proteins
HPK19_RS02120	COG4946	Tricorn protease homolog
HPK19_RS02120	COG1506	peptidase
HPK19_RS02125	COG1473	amidohydrolase
HPK19_RS02130	COG3402	PFAM membrane-flanked domain
HPK19_RS02135	COG3428	Bacterial PH domain
HPK19_RS02140	COG0277	FAD linked oxidase domain protein
HPK19_RS02145	COG2271	Major facilitator Superfamily
HPK19_RS02155	COG2814	Major facilitator Superfamily
HPK19_RS02160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPK19_RS02170	COG0778	Nitroreductase
HPK19_RS02175	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HPK19_RS02185	COG0351	phosphomethylpyrimidine kinase
HPK19_RS02190	COG0833	amino acid
HPK19_RS02200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_RS02215	COG0604	alcohol dehydrogenase
HPK19_RS02220	COG2197	response regulator
HPK19_RS02230	COG1131	(ABC) transporter
HPK19_RS02235	COG0842	Transport permease protein
HPK19_RS02260	COG2207	Transcriptional regulator
HPK19_RS02265	COG0346	lactoylglutathione lyase activity
HPK19_RS02275	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HPK19_RS02290	COG0805	protein transport
HPK19_RS02310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPK19_RS02330	COG0561	phosphatase activity
HPK19_RS02365	COG1979	alcohol dehydrogenase
HPK19_RS02370	COG1073	alpha beta
HPK19_RS02390	COG2368	4-hydroxyphenylacetate
HPK19_RS02410	COG0251	oxidation-reduction process
HPK19_RS02445	COG2814	Major facilitator Superfamily
HPK19_RS02455	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPK19_RS02455	COG0456	acetyltransferase
HPK19_RS02460	COG0667	Aldo Keto reductase
HPK19_RS02485	COG1300	Membrane
HPK19_RS02490	COG0735	belongs to the Fur family
HPK19_RS02500	COG4974	Belongs to the 'phage' integrase family
HPK19_RS02505	COG0024	Methionine aminopeptidase
HPK19_RS02510	COG0861	Integral membrane protein TerC family
HPK19_RS02515	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPK19_RS02520	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HPK19_RS02545	COG1131	(ABC) transporter
HPK19_RS02550	COG1725	Transcriptional regulator
HPK19_RS02555	COG1686	Belongs to the peptidase S11 family
HPK19_RS02565	COG2172	sigma factor antagonist activity
HPK19_RS02570	COG1191	sigma factor activity
HPK19_RS02590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPK19_RS02605	COG0697	spore germination
HPK19_RS02610	COG4086	secreted protein
HPK19_RS02615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPK19_RS02630	COG1547	Domain of unknown function (DUF309)
HPK19_RS02640	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HPK19_RS02645	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HPK19_RS02660	COG4129	membrane
HPK19_RS02665	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPK19_RS02670	COG1686	Belongs to the peptidase S11 family
HPK19_RS02675	COG2715	membrane protein required for spore maturation
HPK19_RS02680	COG0700	Nucleoside recognition
HPK19_RS02685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPK19_RS02690	COG0626	cystathionine gamma-synthase activity
HPK19_RS02695	COG2226	methyltransferase
HPK19_RS02700	COG1854	S-ribosylhomocysteine lyase activity
HPK19_RS02715	COG1187	pseudouridine synthase activity
HPK19_RS02725	COG1333	cytochrome c biogenesis protein
HPK19_RS02730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPK19_RS02735	COG0745	RESPONSE REGULATOR receiver
HPK19_RS02740	COG5002	protein histidine kinase activity
HPK19_RS02745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPK19_RS02750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK19_RS02755	COG1120	ATPase activity
HPK19_RS02760	COG2096	Adenosyltransferase
HPK19_RS02775	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HPK19_RS02790	COG0514	ATP-dependent DNA helicase (RecQ)
HPK19_RS02820	COG4862	establishment of competence for transformation
HPK19_RS02825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPK19_RS02830	COG0492	ferredoxin-NADP+ reductase activity
HPK19_RS02845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPK19_RS02865	COG1160	GTP binding
HPK19_RS02870	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPK19_RS02890	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HPK19_RS02895	COG0776	regulation of translation
HPK19_RS02900	COG0302	gtp cyclohydrolase
HPK19_RS02905	COG0142	geranyltranstransferase activity
HPK19_RS02910	COG2226	methyltransferase
HPK19_RS02915	COG0142	geranyltranstransferase activity
HPK19_RS02920	COG0105	UTP biosynthetic process
HPK19_RS02930	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPK19_RS02935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HPK19_RS02940	COG0457	Tetratricopeptide repeat
HPK19_RS02945	COG5582	Belongs to the UPF0302 family
HPK19_RS02960	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPK19_RS02970	COG4347	Protein of unknown function (DUF1405)
HPK19_RS02980	COG2738	Putative neutral zinc metallopeptidase
HPK19_RS02985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPK19_RS02990	COG1694	Mazg nucleotide pyrophosphohydrolase
HPK19_RS03005	COG0438	transferase activity, transferring glycosyl groups
HPK19_RS03010	COG0617	tRNA 3'-terminal CCA addition
HPK19_RS03015	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HPK19_RS03015	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HPK19_RS03020	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPK19_RS03025	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPK19_RS03035	COG1199	ATP-dependent helicase activity
HPK19_RS03035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPK19_RS03055	COG3935	DnaD domain protein
HPK19_RS03060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPK19_RS03070	COG4499	WXG100 protein secretion system (Wss), protein YukC
HPK19_RS03070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPK19_RS03100	COG2188	Transcriptional regulator
HPK19_RS03105	COG4474	Belongs to the UPF0398 family
HPK19_RS03120	COG0116	Belongs to the methyltransferase superfamily
HPK19_RS03125	COG0582	viral genome integration into host DNA
HPK19_RS03210	COG0740	serine-type endopeptidase activity
HPK19_RS03355	COG1674	ftsk spoiiie
HPK19_RS03385	COG3655	Transcriptional regulator
HPK19_RS03400	COG0673	inositol 2-dehydrogenase activity
HPK19_RS03405	COG1199	ATP-dependent helicase activity
HPK19_RS03435	COG0702	epimerase
HPK19_RS03440	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPK19_RS03460	COG0640	Transcriptional regulator
HPK19_RS03465	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPK19_RS03470	COG3424	synthase
HPK19_RS03475	COG1755	Isoprenylcysteine carboxyl methyltransferase
HPK19_RS03480	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HPK19_RS03500	COG0328	RNA-DNA hybrid ribonuclease activity
HPK19_RS03505	COG0328	RNA-DNA hybrid ribonuclease activity
HPK19_RS03545	COG3949	Membrane
HPK19_RS03555	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPK19_RS03560	COG1183	phosphatidylcholine synthase activity
HPK19_RS03565	COG4166	transmembrane transport
HPK19_RS03570	COG4166	transmembrane transport
HPK19_RS03575	COG0586	Pfam SNARE associated Golgi protein
HPK19_RS03590	COG0701	Predicted permease
HPK19_RS03595	COG3689	TIGRFAM TIGR03943 family protein
HPK19_RS03605	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPK19_RS03640	COG1132	(ABC) transporter
HPK19_RS03660	COG0386	Belongs to the glutathione peroxidase family
HPK19_RS03665	COG1418	mRNA catabolic process
HPK19_RS03670	COG0488	(ABC) transporter
HPK19_RS03680	COG1413	lyase activity
HPK19_RS03690	COG2521	methyltransferase
HPK19_RS03690	COG2136	Putative SAM-dependent methyltransferase
HPK19_RS03705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPK19_RS03710	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HPK19_RS03720	COG1272	protein, Hemolysin III
HPK19_RS03725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPK19_RS03735	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPK19_RS03740	COG1307	EDD domain protein, DegV family
HPK19_RS03750	COG1999	signal sequence binding
HPK19_RS03760	COG1247	-acetyltransferase
HPK19_RS03785	COG0789	Transcriptional regulator
HPK19_RS03790	COG1253	flavin adenine dinucleotide binding
HPK19_RS03795	COG5506	Protein of unknown function (DUF1694)
HPK19_RS03800	COG4191	Histidine kinase
HPK19_RS03830	COG1609	Transcriptional regulator
HPK19_RS03835	COG0561	phosphatase activity
HPK19_RS03840	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HPK19_RS03845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPK19_RS03850	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HPK19_RS03870	COG0697	spore germination
HPK19_RS03885	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPK19_RS03895	COG0588	phosphoglycerate mutase activity
HPK19_RS03915	COG1509	lysine 2,3-aminomutase activity
HPK19_RS03920	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPK19_RS03955	COG0546	phosphoglycolate phosphatase activity
HPK19_RS03970	COG2226	methyltransferase
HPK19_RS03975	COG0714	Associated with various cellular activities
HPK19_RS04000	COG3231	kanamycin kinase activity
HPK19_RS04030	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPK19_RS04060	COG2318	DinB family
HPK19_RS04070	COG3192	ethanolamine utilization protein
HPK19_RS04080	COG3344	reverse transcriptase
HPK19_RS04095	COG3011	Protein conserved in bacteria
HPK19_RS04100	COG1247	-acetyltransferase
HPK19_RS04150	COG2801	Transposase and inactivated derivatives
HPK19_RS04170	COG3152	Membrane
HPK19_RS04175	COG3655	Transcriptional regulator
HPK19_RS04215	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_RS04260	COG3344	reverse transcriptase
HPK19_RS04300	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HPK19_RS04300	COG5479	isomerase activity
HPK19_RS04305	COG1525	nuclease
HPK19_RS04315	COG1404	Belongs to the peptidase S8 family
HPK19_RS04340	COG1509	lysine 2,3-aminomutase activity
HPK19_RS04390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPK19_RS04395	COG0420	3'-5' exonuclease activity
HPK19_RS04405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK19_RS04410	COG0765	amino acid transport
HPK19_RS04425	COG0011	TIGRFAM Protein of
HPK19_RS04430	COG1309	transcriptional regulator
HPK19_RS04460	COG1346	cytolysis
HPK19_RS04465	COG1380	Effector of murein hydrolase LrgA
HPK19_RS04475	COG0708	Exodeoxyribonuclease III
HPK19_RS04480	COG1051	belongs to the nudix hydrolase family
HPK19_RS04490	COG0705	Rhomboid family
HPK19_RS04505	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HPK19_RS04515	COG1307	EDD domain protein, DegV family
HPK19_RS04525	COG2814	Major facilitator Superfamily
HPK19_RS04530	COG3103	Sh3 type 3 domain protein
HPK19_RS04535	COG0346	lactoylglutathione lyase activity
HPK19_RS04550	COG0697	spore germination
HPK19_RS04555	COG0561	phosphatase activity
HPK19_RS04570	COG1033	growth of symbiont in host cell
HPK19_RS04570	COG2409	Drug exporters of the RND superfamily
HPK19_RS04580	COG4974	Belongs to the 'phage' integrase family
HPK19_RS04730	COG1131	(ABC) transporter
HPK19_RS04750	COG0745	RESPONSE REGULATOR receiver
HPK19_RS04755	COG1404	Belongs to the peptidase S8 family
HPK19_RS04760	COG3964	amidohydrolase
HPK19_RS04780	COG2188	Transcriptional regulator
HPK19_RS04790	COG0346	lactoylglutathione lyase activity
HPK19_RS04805	COG3706	GGDEF domain
HPK19_RS04815	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPK19_RS04820	COG5002	protein histidine kinase activity
HPK19_RS04825	COG0745	RESPONSE REGULATOR receiver
HPK19_RS04835	COG3239	Fatty acid desaturase
HPK19_RS04840	COG4585	Histidine kinase
HPK19_RS04845	COG2197	response regulator
HPK19_RS04850	COG2267	carboxylic ester hydrolase activity
HPK19_RS04865	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HPK19_RS04880	COG0406	alpha-ribazole phosphatase activity
HPK19_RS04935	COG2318	DinB family
HPK19_RS04940	COG1349	DNA-binding transcription factor activity
HPK19_RS04945	COG1105	Belongs to the carbohydrate kinase PfkB family
HPK19_RS04950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK19_RS04950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK19_RS04950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK19_RS04955	COG0697	spore germination
HPK19_RS04960	COG0531	amino acid
HPK19_RS04970	COG1272	protein, Hemolysin III
HPK19_RS04980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPK19_RS05000	COG2733	membrane
HPK19_RS05005	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPK19_RS05015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HPK19_RS05025	COG2706	6-phosphogluconolactonase activity
HPK19_RS05045	COG1183	phosphatidylcholine synthase activity
HPK19_RS05085	COG0778	Nitroreductase
HPK19_RS05090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPK19_RS05090	COG3153	acetyltransferase
HPK19_RS05100	COG2801	Transposase and inactivated derivatives
HPK19_RS05110	COG1846	Transcriptional regulator
HPK19_RS05115	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_RS05125	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPK19_RS05130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPK19_RS05140	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPK19_RS05145	COG2270	Major facilitator Superfamily
HPK19_RS05150	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_RS05155	COG0681	Belongs to the peptidase S26 family
HPK19_RS05180	COG1937	Protein conserved in bacteria
HPK19_RS05190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK19_RS05210	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HPK19_RS05210	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HPK19_RS05215	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HPK19_RS05215	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HPK19_RS05220	COG1703	isobutyryl-CoA mutase activity
HPK19_RS05225	COG0346	lactoylglutathione lyase activity
HPK19_RS05230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HPK19_RS05235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_RS05245	COG0583	DNA-binding transcription factor activity
HPK19_RS05255	COG2197	response regulator
HPK19_RS05265	COG2072	flavoprotein involved in K transport
HPK19_RS05270	COG2814	Major facilitator Superfamily
HPK19_RS05280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPK19_RS05285	COG2146	nitrite reductase [NAD(P)H] activity
HPK19_RS05290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPK19_RS05290	COG1587	Uroporphyrinogen-III synthase
HPK19_RS05300	COG2116	formate transmembrane transporter activity
HPK19_RS05305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPK19_RS05310	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HPK19_RS05335	COG0025	NhaP-type Na H and K H
HPK19_RS05360	COG1349	DNA-binding transcription factor activity
HPK19_RS05365	COG0673	inositol 2-dehydrogenase activity
HPK19_RS05390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPK19_RS05400	COG2112	serine threonine protein kinase
HPK19_RS05415	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HPK19_RS05420	COG2068	MobA-Related Protein
HPK19_RS05425	COG3852	Histidine kinase
HPK19_RS05430	COG1073	alpha beta
HPK19_RS05435	COG4499	WXG100 protein secretion system (Wss), protein YukC
HPK19_RS05435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPK19_RS05450	COG1393	Belongs to the ArsC family
HPK19_RS05470	COG2304	oxidoreductase activity
HPK19_RS05480	COG1404	Belongs to the peptidase S8 family
HPK19_RS05485	COG2207	Transcriptional regulator
HPK19_RS05490	COG0561	phosphatase activity
HPK19_RS05495	COG2814	Major facilitator Superfamily
HPK19_RS05500	COG1278	Cold shock
HPK19_RS05510	COG0745	RESPONSE REGULATOR receiver
HPK19_RS05525	COG2205	protein histidine kinase activity
HPK19_RS05535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK19_RS05540	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HPK19_RS05545	COG1687	branched-chain amino acid
HPK19_RS05555	COG0697	spore germination
HPK19_RS05560	COG0814	amino acid
HPK19_RS05570	COG3973	AAA domain
HPK19_RS05575	COG1131	(ABC) transporter
HPK19_RS05585	COG1902	pentaerythritol trinitrate reductase activity
HPK19_RS05600	COG2116	formate transmembrane transporter activity
HPK19_RS05610	COG2199	diguanylate cyclase activity
HPK19_RS05610	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPK19_RS05635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPK19_RS05640	COG4641	Protein conserved in bacteria
HPK19_RS05650	COG0463	Glycosyl transferase, family 2
HPK19_RS05655	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HPK19_RS05660	COG1086	Polysaccharide biosynthesis protein
HPK19_RS05665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPK19_RS05670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPK19_RS05675	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPK19_RS05690	COG2089	acid synthase
HPK19_RS05700	COG1846	Transcriptional regulator
HPK19_RS05705	COG2259	Doxx family
HPK19_RS05710	COG2259	Doxx family
HPK19_RS05715	COG0114	fumarate hydratase activity
HPK19_RS05720	COG1940	carbohydrate kinase activity
HPK19_RS05725	COG0346	lactoylglutathione lyase activity
HPK19_RS05730	COG0738	Major facilitator superfamily
HPK19_RS05735	COG1472	Belongs to the glycosyl hydrolase 3 family
HPK19_RS05750	COG0640	Transcriptional regulator
HPK19_RS05755	COG0798	PFAM Bile acid sodium symporter
HPK19_RS05770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK19_RS05775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK19_RS05785	COG1846	Transcriptional regulator
HPK19_RS05790	COG0778	Nitroreductase
HPK19_RS05815	COG2267	carboxylic ester hydrolase activity
HPK19_RS05855	COG2959	enzyme of heme biosynthesis
HPK19_RS05905	COG0745	RESPONSE REGULATOR receiver
HPK19_RS05910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPK19_RS05915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK19_RS05935	COG0166	Belongs to the GPI family
HPK19_RS05945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPK19_RS05970	COG3196	Protein conserved in bacteria
HPK19_RS05985	COG1268	BioY protein
HPK19_RS05990	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_RS05995	COG0183	Belongs to the thiolase family
HPK19_RS06010	COG1280	lysine exporter protein (LysE YggA)
HPK19_RS06080	COG4978	Transcriptional regulator
HPK19_RS06080	COG0789	Transcriptional regulator
HPK19_RS06085	COG2814	Major facilitator Superfamily
HPK19_RS06105	COG0435	Glutathione S-transferase
HPK19_RS06110	COG0456	acetyltransferase
HPK19_RS06150	COG1279	arginine transmembrane transporter activity
HPK19_RS06165	COG2318	DinB family
HPK19_RS06170	COG1227	inorganic diphosphatase activity
HPK19_RS06180	COG4221	oxidoreductase activity
HPK19_RS06205	COG0469	pyruvate kinase activity
HPK19_RS06215	COG1404	Belongs to the peptidase S8 family
HPK19_RS06225	COG4873	Protein conserved in bacteria
HPK19_RS06230	COG1830	Aldolase
HPK19_RS06250	COG0393	Putative heavy-metal-binding
HPK19_RS06265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPK19_RS06275	COG0586	Pfam SNARE associated Golgi protein
HPK19_RS06280	COG5002	protein histidine kinase activity
HPK19_RS06285	COG0745	RESPONSE REGULATOR receiver
HPK19_RS06290	COG0671	phosphoesterase, PA-phosphatase related
HPK19_RS06295	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPK19_RS06300	COG2860	membrane
HPK19_RS06310	COG0697	spore germination
HPK19_RS06320	COG1649	PFAM Uncharacterised BCR, COG1649
HPK19_RS06325	COG0514	ATP-dependent DNA helicase (RecQ)
HPK19_RS06330	COG1671	Belongs to the UPF0178 family
HPK19_RS06335	COG1187	pseudouridine synthase activity
HPK19_RS06340	COG0666	response to abiotic stimulus
HPK19_RS06345	COG1984	allophanate hydrolase subunit 2
HPK19_RS06350	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPK19_RS06355	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HPK19_RS06360	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HPK19_RS06385	COG1609	Transcriptional regulator
HPK19_RS06410	COG1316	TRANSCRIPTIONal
HPK19_RS06415	COG3459	Glycosyltransferase 36 associated
HPK19_RS06420	COG3459	Glycosyltransferase 36 associated
HPK19_RS06430	COG0673	inositol 2-dehydrogenase activity
HPK19_RS06435	COG1082	Xylose isomerase domain protein TIM barrel
HPK19_RS06515	COG2318	DinB family
HPK19_RS06520	COG3483	tryptophan 2,3-dioxygenase activity
HPK19_RS06540	COG1164	Oligoendopeptidase f
HPK19_RS06545	COG0531	amino acid
HPK19_RS06555	COG1132	(ABC) transporter
HPK19_RS06560	COG1132	(ABC) transporter
HPK19_RS06570	COG1388	LysM domain
HPK19_RS06570	COG3584	3D domain protein
HPK19_RS06585	COG0083	homoserine kinase activity
HPK19_RS06590	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPK19_RS06595	COG0460	homoserine dehydrogenase
HPK19_RS06605	COG1410	methionine synthase
HPK19_RS06605	COG0646	methionine synthase
HPK19_RS06610	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPK19_RS06610	COG0646	methionine synthase
HPK19_RS06615	COG1657	PFAM Prenyltransferase squalene oxidase
HPK19_RS06640	COG2814	Major facilitator Superfamily
HPK19_RS06650	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPK19_RS06660	COG0010	Belongs to the arginase family
HPK19_RS06665	COG1228	amidohydrolase
HPK19_RS06675	COG2986	histidine ammonia-lyase
HPK19_RS06700	COG5609	conserved protein (DUF2294)
HPK19_RS06705	COG2968	Membrane
HPK19_RS06715	COG0666	response to abiotic stimulus
HPK19_RS06720	COG4166	transmembrane transport
HPK19_RS06730	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPK19_RS06735	COG0745	RESPONSE REGULATOR receiver
HPK19_RS06750	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_RS06755	COG1994	Peptidase M50
HPK19_RS06770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPK19_RS06780	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HPK19_RS06785	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPK19_RS06790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPK19_RS06795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_RS06805	COG0183	Belongs to the thiolase family
HPK19_RS06810	COG1960	acyl-CoA dehydrogenase activity
HPK19_RS06815	COG0604	alcohol dehydrogenase
HPK19_RS06825	COG1307	EDD domain protein, DegV family
HPK19_RS06830	COG1378	Sugar-specific transcriptional regulator TrmB
HPK19_RS06850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPK19_RS06860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPK19_RS06870	COG0440	acetolactate synthase activity
HPK19_RS06875	COG0028	Belongs to the TPP enzyme family
HPK19_RS06880	COG0129	dihydroxy-acid dehydratase activity
HPK19_RS06885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPK19_RS06895	COG1174	glycine betaine transport
HPK19_RS06915	COG0590	tRNA wobble adenosine to inosine editing
HPK19_RS06920	COG3339	Conserved Protein
HPK19_RS06925	COG0488	(ABC) transporter
HPK19_RS06930	COG5658	integral membrane protein
HPK19_RS06935	COG0640	Transcriptional regulator
HPK19_RS06940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPK19_RS06960	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPK19_RS06965	COG2962	Rard protein
HPK19_RS06970	COG2814	Major facilitator Superfamily
HPK19_RS06975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPK19_RS06985	COG0672	)-iron permease
HPK19_RS06990	COG2837	iron assimilation
HPK19_RS06995	COG2822	iron ion transport
HPK19_RS07035	COG1132	(ABC) transporter
HPK19_RS07045	COG0604	alcohol dehydrogenase
HPK19_RS07065	COG0456	acetyltransferase
HPK19_RS07065	COG1214	PFAM Peptidase M22, glycoprotease
HPK19_RS07070	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_RS07075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPK19_RS07080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPK19_RS07085	COG2197	response regulator
HPK19_RS07090	COG4585	Histidine kinase
HPK19_RS07095	COG4758	membrane
HPK19_RS07105	COG3104	oligopeptide transport
HPK19_RS07110	COG0756	dUTP diphosphatase activity
HPK19_RS07115	COG0456	acetyltransferase
HPK19_RS07145	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_RS07150	COG1960	acyl-CoA dehydrogenase activity
HPK19_RS07175	COG1309	transcriptional regulator
HPK19_RS07180	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_RS07190	COG1960	acyl-CoA dehydrogenase activity
HPK19_RS07200	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_RS07205	COG0477	Major facilitator Superfamily
HPK19_RS07210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPK19_RS07215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK19_RS07220	COG2124	cytochrome p450
HPK19_RS07230	COG0598	Magnesium transport protein CorA
HPK19_RS07265	COG0423	glycine-tRNA ligase activity
HPK19_RS07280	COG0411	ABC transporter
HPK19_RS07300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPK19_RS07305	COG0187	DNA topoisomerase II activity
HPK19_RS07310	COG1832	CoA-binding protein
HPK19_RS07315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPK19_RS07320	COG5002	protein histidine kinase activity
HPK19_RS07325	COG0745	RESPONSE REGULATOR receiver
HPK19_RS07330	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPK19_RS07335	COG0824	Thioesterase
HPK19_RS07370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPK19_RS07375	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPK19_RS07435	COG5632	N-Acetylmuramoyl-L-alanine amidase
HPK19_RS07460	COG3953	SLT domain
HPK19_RS07460	COG5280	Phage tail tape measure protein TP901
HPK19_RS07525	COG4626	Terminase
HPK19_RS07525	COG1802	Transcriptional regulator
HPK19_RS07555	COG0732	type I restriction modification DNA specificity domain
HPK19_RS07570	COG3655	Transcriptional regulator
HPK19_RS07610	COG3646	Phage regulatory protein
HPK19_RS07610	COG3645	SOS response
HPK19_RS07630	COG1396	sequence-specific DNA binding
HPK19_RS07640	COG0582	viral genome integration into host DNA
HPK19_RS07665	COG2719	SpoVR family
HPK19_RS07675	COG1329	Transcriptional regulator
HPK19_RS07680	COG1278	Cold shock
HPK19_RS07720	COG4846	Membrane protein involved in cytochrome C biogenesis
HPK19_RS07725	COG0785	Cytochrome C biogenesis protein
HPK19_RS07730	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HPK19_RS07745	COG1132	(ABC) transporter
HPK19_RS07750	COG1132	(ABC) transporter
HPK19_RS07760	COG3763	UPF0154 protein
HPK19_RS07770	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPK19_RS07775	COG4224	UPF0291 protein
HPK19_RS07780	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPK19_RS07785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPK19_RS07810	COG1376	ErfK ybiS ycfS ynhG family protein
HPK19_RS07820	COG2205	protein histidine kinase activity
HPK19_RS07830	COG1408	metallophosphoesterase
HPK19_RS07860	COG0659	secondary active sulfate transmembrane transporter activity
HPK19_RS07875	COG1714	RDD family
HPK19_RS07880	COG2861	carbohydrate metabolic process
HPK19_RS07885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPK19_RS07910	COG5646	InterPro IPR014922
HPK19_RS07935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPK19_RS07950	COG5002	protein histidine kinase activity
HPK19_RS07960	COG1136	(ABC) transporter
HPK19_RS07965	COG0577	efflux transmembrane transporter activity
HPK19_RS07970	COG1785	Belongs to the alkaline phosphatase family
HPK19_RS08015	COG1595	DNA-templated transcription, initiation
HPK19_RS08025	COG0463	Glycosyl transferase, family 2
HPK19_RS08060	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPK19_RS08065	COG1247	-acetyltransferase
HPK19_RS08105	COG3345	alpha-galactosidase
HPK19_RS08110	COG0395	ABC-type sugar transport system, permease component
HPK19_RS08115	COG1175	transmembrane transport
HPK19_RS08125	COG1609	Transcriptional regulator
HPK19_RS08135	COG0813	purine-nucleoside phosphorylase activity
HPK19_RS08150	COG0174	glutamine synthetase
HPK19_RS08155	COG0174	glutamine synthetase
HPK19_RS08160	COG0789	Transcriptional regulator
HPK19_RS08165	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HPK19_RS08170	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HPK19_RS08175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPK19_RS08180	COG0436	Aminotransferase
HPK19_RS08185	COG1850	ribulose-bisphosphate carboxylase activity
HPK19_RS08195	COG0235	Class ii aldolase
HPK19_RS08205	COG2323	membrane
HPK19_RS08210	COG0531	amino acid
HPK19_RS08235	COG1309	transcriptional regulator
HPK19_RS08240	COG2814	Major facilitator Superfamily
HPK19_RS08245	COG1231	oxidoreductase activity
HPK19_RS08250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPK19_RS08255	COG2720	vancomycin resistance protein
HPK19_RS08270	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HPK19_RS08285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPK19_RS08290	COG2070	2-Nitropropane dioxygenase
HPK19_RS08325	COG1278	Cold shock
HPK19_RS08345	COG1051	belongs to the nudix hydrolase family
HPK19_RS08400	COG2723	6-phospho-beta-galactosidase activity
HPK19_RS08410	COG0501	Belongs to the peptidase M48B family
HPK19_RS08415	COG1376	ErfK ybiS ycfS ynhG family protein
HPK19_RS08445	COG1819	glycosyl
HPK19_RS08480	COG1846	Transcriptional regulator
HPK19_RS08490	COG3739	integral membrane protein
HPK19_RS08495	COG3655	Transcriptional regulator
HPK19_RS08530	COG0477	Major facilitator Superfamily
HPK19_RS08540	COG2824	Alkylphosphonate utilization operon protein PhnA
HPK19_RS08545	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HPK19_RS08550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPK19_RS08565	COG0598	Magnesium transport protein CorA
HPK19_RS08570	COG0464	growth
HPK19_RS08580	COG2808	Putative FMN-binding domain
HPK19_RS08595	COG0167	dihydroorotate dehydrogenase activity
HPK19_RS08610	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPK19_RS08620	COG2814	Major facilitator Superfamily
HPK19_RS08625	COG0531	amino acid
HPK19_RS08645	COG2814	Major facilitator Superfamily
HPK19_RS08650	COG1902	pentaerythritol trinitrate reductase activity
HPK19_RS08660	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPK19_RS08665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPK19_RS08675	COG2801	Transposase and inactivated derivatives
HPK19_RS08710	COG0656	L-ascorbic acid biosynthetic process
HPK19_RS08715	COG0584	glycerophosphoryl diester phosphodiesterase
HPK19_RS08725	COG0395	ABC-type sugar transport system, permease component
HPK19_RS08730	COG4209	transmembrane transport
HPK19_RS08735	COG1653	transport
HPK19_RS08740	COG1609	Transcriptional regulator
HPK19_RS08750	COG0383	alpha-mannosidase activity
HPK19_RS08760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK19_RS08760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK19_RS08770	COG3718	enzyme involved in inositol metabolism
HPK19_RS08775	COG1082	Xylose isomerase domain protein TIM barrel
HPK19_RS08780	COG3962	Belongs to the TPP enzyme family
HPK19_RS08795	COG0673	inositol 2-dehydrogenase activity
HPK19_RS08800	COG1609	Transcriptional regulator
HPK19_RS08815	COG0346	lactoylglutathione lyase activity
HPK19_RS08830	COG0110	maltose O-acetyltransferase activity
HPK19_RS08835	COG2226	methyltransferase
HPK19_RS08850	COG0626	cystathionine gamma-synthase activity
HPK19_RS08855	COG0626	cystathionine gamma-synthase activity
HPK19_RS08860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPK19_RS08860	COG1199	ATP-dependent helicase activity
HPK19_RS08870	COG1132	(ABC) transporter
HPK19_RS08875	COG1132	(ABC) transporter
HPK19_RS08880	COG0366	Alpha amylase catalytic
HPK19_RS08885	COG1376	ErfK ybiS ycfS ynhG family protein
HPK19_RS08890	COG1363	Peptidase, m42
HPK19_RS08900	COG3961	Belongs to the TPP enzyme family
HPK19_RS08925	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_RS08930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPK19_RS08935	COG0488	(ABC) transporter
HPK19_RS08940	COG1607	acyl-coa hydrolase
HPK19_RS08980	COG0456	acetyltransferase
HPK19_RS09010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPK19_RS09045	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HPK19_RS09080	COG0140	phosphoribosyl-ATP diphosphatase activity
HPK19_RS09080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPK19_RS09085	COG0107	imidazoleglycerol-phosphate synthase activity
HPK19_RS09090	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPK19_RS09095	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPK19_RS09100	COG0131	Imidazoleglycerol-phosphate dehydratase
HPK19_RS09105	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPK19_RS09110	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPK19_RS09115	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HPK19_RS09160	COG1051	belongs to the nudix hydrolase family
HPK19_RS09165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPK19_RS09170	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPK19_RS09175	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPK19_RS09180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPK19_RS09185	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HPK19_RS09190	COG1733	regulation of RNA biosynthetic process
HPK19_RS09195	COG0655	NAD(P)H dehydrogenase (quinone) activity
HPK19_RS09200	COG1979	alcohol dehydrogenase
HPK19_RS09205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK19_RS09215	COG0346	lactoylglutathione lyase activity
HPK19_RS09220	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPK19_RS09235	COG4550	Control of competence regulator ComK, YlbF/YmcA
HPK19_RS09240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPK19_RS09245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPK19_RS09255	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPK19_RS09260	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPK19_RS09260	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPK19_RS09270	COG2359	stage V sporulation protein S
HPK19_RS09275	COG1692	metallophosphoesterase
HPK19_RS09280	COG1418	mRNA catabolic process
HPK19_RS09290	COG1546	Belongs to the CinA family
HPK19_RS09290	COG1058	Belongs to the CinA family
HPK19_RS09295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPK19_RS09300	COG1426	Protein conserved in bacteria
HPK19_RS09310	COG0300	oxidoreductase activity
HPK19_RS09315	COG0612	Peptidase, M16
HPK19_RS09320	COG0612	Peptidase, M16
HPK19_RS09340	COG1744	ABC transporter substrate-binding protein PnrA-like
HPK19_RS09345	COG2188	Transcriptional regulator
HPK19_RS09360	COG0740	serine-type endopeptidase activity
HPK19_RS09365	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPK19_RS09370	COG3848	Pyruvate phosphate dikinase
HPK19_RS09370	COG0574	Belongs to the PEP-utilizing enzyme family
HPK19_RS09375	COG2132	Multicopper oxidase
HPK19_RS09385	COG0527	aspartate kinase activity
HPK19_RS09390	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPK19_RS09395	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPK19_RS09415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPK19_RS09420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPK19_RS09425	COG0612	Peptidase, M16
HPK19_RS09430	COG0726	polysaccharide deacetylase
HPK19_RS09435	COG1185	polyribonucleotide nucleotidyltransferase activity
HPK19_RS09445	COG0196	riboflavin kinase activity
HPK19_RS09455	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPK19_RS09460	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPK19_RS09465	COG1358	cellular component organization or biogenesis
HPK19_RS09470	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HPK19_RS09475	COG0195	Participates in both transcription termination and antitermination
HPK19_RS09480	COG0779	Required for maturation of 30S ribosomal subunits
HPK19_RS09495	COG0750	zinc metalloprotease
HPK19_RS09500	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPK19_RS09505	COG4589	Belongs to the CDS family
HPK19_RS09515	COG0233	cytoplasmic translational termination
HPK19_RS09525	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPK19_RS09530	COG0052	Belongs to the universal ribosomal protein uS2 family
HPK19_RS09535	COG1191	sigma factor activity
HPK19_RS09540	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HPK19_RS09545	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPK19_RS09550	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPK19_RS09555	COG4974	Belongs to the 'phage' integrase family
HPK19_RS09565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPK19_RS09570	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPK19_RS09570	COG0758	DNA mediated transformation
HPK19_RS09575	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPK19_RS09585	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPK19_RS09610	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPK19_RS09615	COG1837	Belongs to the UPF0109 family
HPK19_RS09625	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPK19_RS09630	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HPK19_RS09635	COG0552	protein localization to endoplasmic reticulum
HPK19_RS09640	COG1196	nuclear chromosome segregation
HPK19_RS09645	COG0571	ribonuclease III activity
HPK19_RS09650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPK19_RS09655	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_RS09660	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPK19_RS09670	COG1349	DNA-binding transcription factor activity
HPK19_RS09675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPK19_RS09680	COG1760	l-serine dehydratase
HPK19_RS09685	COG1760	l-serine dehydratase
HPK19_RS09690	COG1461	Dihydroxyacetone kinase
HPK19_RS09695	COG1302	Protein conserved in bacteria
HPK19_RS09700	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPK19_RS09710	COG1564	THIamine pyrophosphokinase
HPK19_RS09715	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPK19_RS09720	COG1162	GTPase activity
HPK19_RS09725	COG0515	serine threonine protein kinase
HPK19_RS09725	COG2815	serine threonine protein kinase
HPK19_RS09730	COG0631	protein serine/threonine phosphatase activity
HPK19_RS09740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPK19_RS09740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPK19_RS09745	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPK19_RS09755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPK19_RS09760	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPK19_RS09765	COG1758	RNA polymerase activity
HPK19_RS09775	COG1561	YicC-like family, N-terminal region
HPK19_RS09780	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HPK19_RS09800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPK19_RS09805	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HPK19_RS09810	COG1132	(ABC) transporter
HPK19_RS09815	COG1132	(ABC) transporter
HPK19_RS09830	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HPK19_RS09855	COG3344	reverse transcriptase
HPK19_RS09870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPK19_RS09885	COG0543	2 iron, 2 sulfur cluster binding
HPK19_RS09890	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPK19_RS09900	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPK19_RS09905	COG0540	Belongs to the ATCase OTCase family
HPK19_RS09920	COG0564	pseudouridine synthase activity
HPK19_RS09930	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPK19_RS09940	COG2340	Cysteine-rich secretory protein family
HPK19_RS09950	COG3599	regulation of cell shape
HPK19_RS09955	COG2302	S4 RNA-binding domain
HPK19_RS09960	COG0762	integral membrane protein
HPK19_RS09965	COG1799	cell septum assembly
HPK19_RS09970	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPK19_RS09980	COG1873	PFAM PRC-barrel domain
HPK19_RS09985	COG1191	sigma factor activity
HPK19_RS09990	COG1191	sigma factor activity
HPK19_RS10000	COG1216	Glycosyl transferase, family 2
HPK19_RS10000	COG0438	transferase activity, transferring glycosyl groups
HPK19_RS10005	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPK19_RS10010	COG0849	cell division
HPK19_RS10015	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPK19_RS10030	COG0772	Belongs to the SEDS family
HPK19_RS10040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPK19_RS10045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPK19_RS10050	COG0768	penicillin binding
HPK19_RS10065	COG0275	rRNA processing
HPK19_RS10070	COG2001	Belongs to the MraZ family
HPK19_RS10085	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPK19_RS10090	COG0454	-acetyltransferase
HPK19_RS10100	COG1024	Enoyl-CoA hydratase
HPK19_RS10105	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPK19_RS10110	COG1399	metal-binding, possibly nucleic acid-binding protein
HPK19_RS10115	COG1323	Belongs to the UPF0348 family
HPK19_RS10120	COG3480	Lon protease (S16) C-terminal proteolytic domain
HPK19_RS10125	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPK19_RS10130	COG3314	Sporulation integral membrane protein YlbJ
HPK19_RS10135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPK19_RS10140	COG0742	ribosomal rna small subunit methyltransferase
HPK19_RS10150	COG4471	UPF0298 protein
HPK19_RS10155	COG3679	Belongs to the UPF0342 family
HPK19_RS10160	COG0406	alpha-ribazole phosphatase activity
HPK19_RS10175	COG2340	Cysteine-rich secretory protein family
HPK19_RS10190	COG3336	cytochrome c oxidase
HPK19_RS10195	COG0583	DNA-binding transcription factor activity
HPK19_RS10200	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HPK19_RS10205	COG1845	cytochrome c oxidase, subunit III
HPK19_RS10210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPK19_RS10220	COG0109	protoheme IX farnesyltransferase activity
HPK19_RS10225	COG1612	heme a metabolic process
HPK19_RS10230	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HPK19_RS10235	COG0772	Belongs to the SEDS family
HPK19_RS10240	COG4838	Belongs to the UPF0358 family
HPK19_RS10245	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HPK19_RS10250	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPK19_RS10260	COG4896	Protein conserved in bacteria
HPK19_RS10285	COG0483	inositol monophosphate 1-phosphatase activity
HPK19_RS10300	COG4476	Belongs to the UPF0223 family
HPK19_RS10305	COG1982	Orn Lys Arg decarboxylase major
HPK19_RS10345	COG0022	dehydrogenase e1 component
HPK19_RS10350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPK19_RS10365	COG0242	peptide deformylase activity
HPK19_RS10370	COG0561	phosphatase activity
HPK19_RS10385	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPK19_RS10400	COG1294	oxidase, subunit
HPK19_RS10405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPK19_RS10410	COG0450	alkyl hydroperoxide reductase
HPK19_RS10415	COG1473	amidohydrolase
HPK19_RS10425	COG0583	DNA-binding transcription factor activity
HPK19_RS10430	COG0517	IMP dehydrogenase activity
HPK19_RS10440	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HPK19_RS10445	COG4703	Protein of unknown function (DUF1797)
HPK19_RS10460	COG2200	EAL domain
HPK19_RS10465	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_RS10470	COG1408	metallophosphoesterase
HPK19_RS10495	COG2205	protein histidine kinase activity
HPK19_RS10500	COG0598	Magnesium transport protein CorA
HPK19_RS10505	COG0436	Aminotransferase
HPK19_RS10515	COG2084	Dehydrogenase
HPK19_RS10520	COG0778	Nitroreductase
HPK19_RS10525	COG0640	Transcriptional regulator
HPK19_RS10540	COG1263	PTS System
HPK19_RS10540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK19_RS10540	COG2190	(PTS) system
HPK19_RS10545	COG3711	transcriptional antiterminator
HPK19_RS10550	COG0561	phosphatase activity
HPK19_RS10555	COG2188	Transcriptional regulator
HPK19_RS10565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPK19_RS10570	COG2333	competence protein COMEC
HPK19_RS10570	COG0658	competence protein
HPK19_RS10590	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPK19_RS10595	COG1801	Protein of unknown function DUF72
HPK19_RS10600	COG5002	protein histidine kinase activity
HPK19_RS10605	COG0604	alcohol dehydrogenase
HPK19_RS10605	COG3321	synthase
HPK19_RS10605	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_RS10610	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPK19_RS10615	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPK19_RS10620	COG1780	Probably involved in ribonucleotide reductase function
HPK19_RS10635	COG4873	Protein conserved in bacteria
HPK19_RS10640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPK19_RS10650	COG1846	Transcriptional regulator
HPK19_RS10660	COG0235	Class ii aldolase
HPK19_RS10665	COG1032	radical SAM domain protein
HPK19_RS10680	COG5577	PFAM Coat F domain
HPK19_RS10690	COG2323	membrane
HPK19_RS10725	COG2030	dehydratase
HPK19_RS10735	COG1263	PTS System
HPK19_RS10735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK19_RS10745	COG2340	Cysteine-rich secretory protein family
HPK19_RS10750	COG3142	Participates in the control of copper homeostasis
HPK19_RS10755	COG0564	pseudouridine synthase activity
HPK19_RS10760	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_RS10760	COG1454	alcohol dehydrogenase
HPK19_RS10765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPK19_RS10775	COG1846	Transcriptional regulator
HPK19_RS10780	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPK19_RS10785	COG1177	transmembrane transport
HPK19_RS10790	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPK19_RS10795	COG3842	ATPase activity
HPK19_RS10800	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_RS10805	COG1392	Phosphate transport regulator
HPK19_RS10810	COG0306	phosphate transporter
HPK19_RS10815	COG1686	Belongs to the peptidase S11 family
HPK19_RS10825	COG2223	nitrite transmembrane transporter activity
HPK19_RS10830	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HPK19_RS10850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPK19_RS10865	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPK19_RS10895	COG2843	Capsule synthesis protein
HPK19_RS10900	COG0714	Associated with various cellular activities
HPK19_RS10915	COG4948	Mandelate Racemase Muconate Lactonizing
HPK19_RS10925	COG1473	amidohydrolase
HPK19_RS10945	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPK19_RS10950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPK19_RS10955	COG0438	transferase activity, transferring glycosyl groups
HPK19_RS10960	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPK19_RS10970	COG1404	Belongs to the peptidase S8 family
HPK19_RS10980	COG0697	spore germination
HPK19_RS10985	COG0531	amino acid
HPK19_RS10995	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPK19_RS11000	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPK19_RS11010	COG0697	spore germination
HPK19_RS11015	COG1404	Belongs to the peptidase S8 family
HPK19_RS11025	COG1113	amino acid transport
HPK19_RS11030	COG3844	kynureninase activity
HPK19_RS11035	COG1309	transcriptional regulator
HPK19_RS11040	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_RS11055	COG1309	transcriptional regulator
HPK19_RS11070	COG0833	amino acid
HPK19_RS11075	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPK19_RS11080	COG0697	spore germination
HPK19_RS11085	COG0583	DNA-binding transcription factor activity
HPK19_RS11090	COG0628	permease
HPK19_RS11105	COG2080	2 iron, 2 sulfur cluster binding
HPK19_RS11115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HPK19_RS11120	COG0697	spore germination
HPK19_RS11140	COG1404	Belongs to the peptidase S8 family
HPK19_RS11145	COG0583	DNA-binding transcription factor activity
HPK19_RS11150	COG1404	Belongs to the peptidase S8 family
HPK19_RS11155	COG0531	amino acid
HPK19_RS11170	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPK19_RS11175	COG0789	Transcriptional regulator
HPK19_RS11180	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_RS11185	COG2205	protein histidine kinase activity
HPK19_RS11190	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HPK19_RS11195	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HPK19_RS11215	COG0517	IMP dehydrogenase activity
HPK19_RS11220	COG1511	domain protein
HPK19_RS11225	COG1309	transcriptional regulator
HPK19_RS11230	COG0583	DNA-binding transcription factor activity
HPK19_RS11245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPK19_RS11250	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_RS11265	COG0167	dihydroorotate dehydrogenase activity
HPK19_RS11270	COG0493	'glutamate synthase
HPK19_RS11280	COG2738	Putative neutral zinc metallopeptidase
HPK19_RS11285	COG0789	Transcriptional regulator
HPK19_RS11290	COG0697	spore germination
HPK19_RS11310	COG4948	Mandelate Racemase Muconate Lactonizing
HPK19_RS11320	COG0737	Belongs to the 5'-nucleotidase family
HPK19_RS11325	COG0583	DNA-binding transcription factor activity
HPK19_RS11340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPK19_RS11350	COG4638	Rieske (2fe-2S)
HPK19_RS11360	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_RS11365	COG0028	Belongs to the TPP enzyme family
HPK19_RS11370	COG1960	acyl-CoA dehydrogenase activity
HPK19_RS11375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPK19_RS11385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPK19_RS11390	COG0833	amino acid
HPK19_RS11395	COG1404	Belongs to the peptidase S8 family
HPK19_RS11400	COG1404	Belongs to the peptidase S8 family
HPK19_RS11410	COG1404	Belongs to the peptidase S8 family
HPK19_RS11415	COG0697	spore germination
HPK19_RS11420	COG0531	amino acid
HPK19_RS11440	COG1404	Belongs to the peptidase S8 family
HPK19_RS11445	COG0667	Aldo Keto reductase
HPK19_RS11460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPK19_RS11465	COG0789	Transcriptional regulator
HPK19_RS11470	COG1064	alcohol dehydrogenase
HPK19_RS11485	COG1280	lysine exporter protein (LysE YggA)
HPK19_RS11490	COG4978	Transcriptional regulator
HPK19_RS11490	COG0789	Transcriptional regulator
HPK19_RS11520	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPK19_RS11525	COG0398	Pfam SNARE associated Golgi protein
HPK19_RS11530	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPK19_RS11540	COG0463	Glycosyl transferase, family 2
HPK19_RS11550	COG1846	Transcriptional regulator
HPK19_RS11575	COG1404	Belongs to the peptidase S8 family
HPK19_RS11580	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_RS11585	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_RS11605	COG1960	acyl-CoA dehydrogenase activity
HPK19_RS11610	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPK19_RS11615	COG0183	Belongs to the thiolase family
HPK19_RS11620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPK19_RS11625	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPK19_RS11640	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_RS11650	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_RS11655	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_RS11660	COG1024	Enoyl-CoA hydratase
HPK19_RS11670	COG0183	Belongs to the thiolase family
HPK19_RS11675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPK19_RS11685	COG0583	DNA-binding transcription factor activity
HPK19_RS11690	COG0656	L-ascorbic acid biosynthetic process
HPK19_RS11715	COG1404	Belongs to the peptidase S8 family
HPK19_RS11720	COG1404	Belongs to the peptidase S8 family
HPK19_RS11725	COG1404	Belongs to the peptidase S8 family
HPK19_RS11730	COG1404	Belongs to the peptidase S8 family
HPK19_RS11735	COG1404	Belongs to the peptidase S8 family
HPK19_RS11740	COG1404	Belongs to the peptidase S8 family
HPK19_RS11755	COG1404	Belongs to the peptidase S8 family
HPK19_RS11760	COG1404	Belongs to the peptidase S8 family
HPK19_RS11770	COG1404	Belongs to the peptidase S8 family
HPK19_RS11775	COG1404	Belongs to the peptidase S8 family
HPK19_RS11790	COG1404	Belongs to the peptidase S8 family
HPK19_RS11795	COG0583	DNA-binding transcription factor activity
HPK19_RS11800	COG1404	Belongs to the peptidase S8 family
HPK19_RS11810	COG1063	alcohol dehydrogenase
HPK19_RS11830	COG1231	oxidoreductase activity
HPK19_RS11835	COG0386	Belongs to the glutathione peroxidase family
HPK19_RS11895	COG0582	viral genome integration into host DNA
HPK19_RS11920	COG0569	domain protein
HPK19_RS11925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPK19_RS11935	COG2382	esterase
HPK19_RS11945	COG2153	protein acetylation
HPK19_RS11950	COG0210	DNA helicase
HPK19_RS11990	COG0772	Belongs to the SEDS family
HPK19_RS12000	COG0564	pseudouridine synthase activity
HPK19_RS12010	COG2357	RelA SpoT domain protein
HPK19_RS12020	COG4116	CYTH
HPK19_RS12030	COG1164	Oligoendopeptidase f
HPK19_RS12040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPK19_RS12050	COG0861	Integral membrane protein TerC family
HPK19_RS12065	COG4608	Belongs to the ABC transporter superfamily
HPK19_RS12070	COG0444	Belongs to the ABC transporter superfamily
HPK19_RS12075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPK19_RS12080	COG0601	transmembrane transport
HPK19_RS12090	COG0180	Tryptophanyl-tRNA synthetase
HPK19_RS12100	COG5504	Zn-dependent protease
HPK19_RS12105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPK19_RS12110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPK19_RS12120	COG2267	carboxylic ester hydrolase activity
HPK19_RS12135	COG0561	phosphatase activity
HPK19_RS12155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPK19_RS12165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPK19_RS12170	COG2996	Protein conserved in bacteria
HPK19_RS12175	COG1666	GTP binding
HPK19_RS12180	COG1609	Transcriptional regulator
HPK19_RS12185	COG1874	Beta-galactosidase
HPK19_RS12185	COG0366	Alpha amylase catalytic
HPK19_RS12195	COG0004	ammonium transporteR
HPK19_RS12200	COG0347	Belongs to the P(II) protein family
HPK19_RS12205	COG0367	asparagine synthase
HPK19_RS12255	COG1074	ATP-dependent DNA helicase activity
HPK19_RS12260	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HPK19_RS12270	COG0398	Pfam SNARE associated Golgi protein
HPK19_RS12275	COG4903	ComK protein
HPK19_RS12280	COG2224	Isocitrate lyase
HPK19_RS12285	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPK19_RS12290	COG0501	Belongs to the peptidase M48B family
HPK19_RS12295	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_RS12300	COG0095	Lipoate-protein ligase
HPK19_RS12305	COG1234	tRNA 3'-trailer cleavage
HPK19_RS12325	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPK19_RS12330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPK19_RS12335	COG1473	amidohydrolase
HPK19_RS12345	COG4473	ABC transporter
HPK19_RS12350	COG1131	(ABC) transporter
HPK19_RS12355	COG0537	adenosine 5'-monophosphoramidase activity
HPK19_RS12360	COG1846	Transcriptional regulator
HPK19_RS12385	COG3481	metal-dependent phosphohydrolase, HD sub domain
HPK19_RS12400	COG1024	Enoyl-CoA hydratase
HPK19_RS12405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPK19_RS12410	COG0561	phosphatase activity
HPK19_RS12425	COG0189	ligase activity
HPK19_RS12430	COG0189	ligase activity
HPK19_RS12440	COG2508	Transcriptional regulator
HPK19_RS12445	COG3842	ATPase activity
HPK19_RS12460	COG1126	abc transporter atp-binding protein
HPK19_RS12465	COG0765	amino acid transport
HPK19_RS12470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK19_RS12475	COG4535	Mg2 and Co2 transporter CorC
HPK19_RS12480	COG1253	flavin adenine dinucleotide binding
HPK19_RS12485	COG0789	Transcriptional regulator
HPK19_RS12500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPK19_RS12505	COG0183	Belongs to the thiolase family
HPK19_RS12510	COG3290	protein histidine kinase activity
HPK19_RS12510	COG3829	transcription factor binding
HPK19_RS12515	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_RS12520	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPK19_RS12525	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPK19_RS12530	COG2610	gluconate transmembrane transporter activity
HPK19_RS12540	COG1404	Belongs to the peptidase S8 family
HPK19_RS12545	COG1408	metallophosphoesterase
HPK19_RS12550	COG0110	maltose O-acetyltransferase activity
HPK19_RS12565	COG0165	Argininosuccinate lyase
HPK19_RS12570	COG0137	argininosuccinate synthase activity
HPK19_RS12575	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HPK19_RS12580	COG0783	Belongs to the Dps family
HPK19_RS12585	COG3541	Predicted nucleotidyltransferase
HPK19_RS12600	COG2223	nitrite transmembrane transporter activity
HPK19_RS12605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK19_RS12610	COG0586	Pfam SNARE associated Golgi protein
HPK19_RS12615	COG2217	Heavy metal translocating P-type atpase
HPK19_RS12620	COG0640	Transcriptional regulator
HPK19_RS12650	COG4912	Dna alkylation repair
HPK19_RS12660	COG0288	reversible hydration of carbon dioxide
HPK19_RS12665	COG0656	L-ascorbic acid biosynthetic process
HPK19_RS12670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPK19_RS12690	COG5002	protein histidine kinase activity
HPK19_RS12695	COG0745	RESPONSE REGULATOR receiver
HPK19_RS12715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPK19_RS12715	COG0723	plastoquinol--plastocyanin reductase activity
HPK19_RS12740	COG1690	Belongs to the RtcB family
HPK19_RS12750	COG0456	acetyltransferase
HPK19_RS12755	COG1335	isochorismatase
HPK19_RS12760	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPK19_RS12765	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPK19_RS12780	COG1231	oxidoreductase activity
HPK19_RS12790	COG1525	nuclease
HPK19_RS12795	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPK19_RS12800	COG0697	spore germination
HPK19_RS12825	COG2059	Chromate
HPK19_RS12830	COG2059	Chromate
HPK19_RS12845	COG1802	Transcriptional regulator
HPK19_RS12865	COG3069	C4-dicarboxylate transmembrane transporter activity
HPK19_RS12895	COG2329	Antibiotic biosynthesis monooxygenase
HPK19_RS12905	COG2814	Major facilitator Superfamily
HPK19_RS12915	COG3832	glyoxalase III activity
HPK19_RS12940	COG5002	protein histidine kinase activity
HPK19_RS12945	COG0745	RESPONSE REGULATOR receiver
HPK19_RS12965	COG1231	oxidoreductase activity
HPK19_RS12970	COG0456	acetyltransferase
HPK19_RS13025	COG0753	catalase activity
HPK19_RS13040	COG2801	Transposase and inactivated derivatives
HPK19_RS13045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPK19_RS13075	COG1349	DNA-binding transcription factor activity
HPK19_RS13090	COG0716	FMN binding
HPK19_RS13115	COG1122	ATPase activity
HPK19_RS13155	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPK19_RS13170	COG0473	3-isopropylmalate dehydrogenase activity
HPK19_RS13175	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_RS13180	COG4638	Rieske (2fe-2S)
HPK19_RS13190	COG1316	TRANSCRIPTIONal
HPK19_RS13200	COG2801	Transposase and inactivated derivatives
HPK19_RS13215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK19_RS13235	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPK19_RS13235	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPK19_RS13240	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPK19_RS13240	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPK19_RS13250	COG1733	regulation of RNA biosynthetic process
HPK19_RS13255	COG1404	Belongs to the peptidase S8 family
HPK19_RS13260	COG1404	Belongs to the peptidase S8 family
HPK19_RS13265	COG1404	Belongs to the peptidase S8 family
HPK19_RS13275	COG0583	DNA-binding transcription factor activity
HPK19_RS13300	COG0583	DNA-binding transcription factor activity
HPK19_RS13305	COG1404	Belongs to the peptidase S8 family
HPK19_RS13325	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPK19_RS13335	COG0412	Dienelactone hydrolase
HPK19_RS13340	COG2814	Major facilitator Superfamily
HPK19_RS13355	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPK19_RS13360	COG1910	domain protein
HPK19_RS13405	COG3964	amidohydrolase
HPK19_RS13425	COG0577	efflux transmembrane transporter activity
HPK19_RS13430	COG1136	(ABC) transporter
HPK19_RS13440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPK19_RS13470	COG1473	amidohydrolase
HPK19_RS13480	COG1113	amino acid transport
HPK19_RS13490	COG3655	Transcriptional regulator
HPK19_RS13495	COG0069	glutamate synthase activity
HPK19_RS13520	COG2271	Major facilitator Superfamily
HPK19_RS13530	COG1737	Transcriptional regulator
HPK19_RS13535	COG2971	BadF BadG BcrA BcrD
HPK19_RS13540	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPK19_RS13545	COG2723	6-phospho-beta-galactosidase activity
HPK19_RS13550	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPK19_RS13555	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_RS13560	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_RS13565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK19_RS13565	COG3711	transcriptional antiterminator
HPK19_RS13580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_RS13585	COG2271	Major facilitator Superfamily
HPK19_RS13600	COG2719	SpoVR family
HPK19_RS13610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPK19_RS13620	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_RS13625	COG2252	PERMEase
HPK19_RS13635	COG4667	esterase of the alpha-beta hydrolase superfamily
HPK19_RS13640	COG2366	antibiotic biosynthetic process
HPK19_RS13650	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HPK19_RS13655	COG1388	LysM domain
HPK19_RS13655	COG0791	NLP P60 protein
HPK19_RS13660	COG0366	Alpha amylase catalytic
HPK19_RS13670	COG0789	Transcriptional regulator
HPK19_RS13675	COG3695	enzyme binding
HPK19_RS13685	COG4841	protein insertion into membrane
HPK19_RS13690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPK19_RS13695	COG3850	Histidine kinase
HPK19_RS13695	COG5002	protein histidine kinase activity
HPK19_RS13715	COG0392	lysyltransferase activity
HPK19_RS13715	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HPK19_RS13720	COG1846	Transcriptional regulator
HPK19_RS13725	COG1764	response to oxidative stress
HPK19_RS13730	COG0390	transport system, permease component
HPK19_RS13735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPK19_RS13740	COG1120	ATPase activity
HPK19_RS13745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK19_RS13750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK19_RS13755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPK19_RS13765	COG4565	transcriptional regulatory protein
HPK19_RS13770	COG3290	protein histidine kinase activity
HPK19_RS13800	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPK19_RS13810	COG5002	protein histidine kinase activity
HPK19_RS13815	COG0745	RESPONSE REGULATOR receiver
HPK19_RS13845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK19_RS13850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPK19_RS13855	COG0748	coenzyme F420 binding
HPK19_RS13870	COG4335	DNA alkylation repair
HPK19_RS13885	COG0406	alpha-ribazole phosphatase activity
HPK19_RS13890	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPK19_RS13895	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HPK19_RS13915	COG1404	Belongs to the peptidase S8 family
HPK19_RS13920	COG1404	Belongs to the peptidase S8 family
HPK19_RS13930	COG1737	Transcriptional regulator
HPK19_RS13945	COG1404	Belongs to the peptidase S8 family
HPK19_RS13950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_RS13955	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPK19_RS13970	COG2264	protein methyltransferase activity
HPK19_RS13985	COG0307	riboflavin synthase, alpha
HPK19_RS13995	COG0583	DNA-binding transcription factor activity
HPK19_RS14010	COG1609	Transcriptional regulator
HPK19_RS14020	COG0531	amino acid
HPK19_RS14050	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPK19_RS14055	COG0352	thiamine-phosphate diphosphorylase activity
HPK19_RS14065	COG2104	thiamine diphosphate biosynthetic process
HPK19_RS14070	COG2022	thiamine diphosphate biosynthetic process
HPK19_RS14075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPK19_RS14085	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_RS14090	COG1027	Aspartate ammonia-lyase
HPK19_RS14095	COG1414	Transcriptional regulator
HPK19_RS14100	COG0477	Major facilitator Superfamily
HPK19_RS14105	COG2608	mercury ion transmembrane transporter activity
HPK19_RS14110	COG2217	Heavy metal translocating P-type atpase
HPK19_RS14115	COG1937	Protein conserved in bacteria
HPK19_RS14130	COG1960	acyl-CoA dehydrogenase activity
HPK19_RS14135	COG0789	Transcriptional regulator
HPK19_RS14140	COG0028	Belongs to the TPP enzyme family
HPK19_RS14145	COG1136	(ABC) transporter
HPK19_RS14150	COG0577	efflux transmembrane transporter activity
HPK19_RS14195	COG3227	Zinc metalloprotease (Elastase)
HPK19_RS14210	COG0697	spore germination
HPK19_RS14225	COG0789	Transcriptional regulator
HPK19_RS14225	COG4978	Transcriptional regulator
HPK19_RS14245	COG1288	antiporter activity
HPK19_RS14250	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPK19_RS14260	COG1464	Belongs to the NlpA lipoprotein family
HPK19_RS14265	COG2011	ABC-type metal ion transport system permease component
HPK19_RS14270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPK19_RS14280	COG0730	response to heat
HPK19_RS14285	COG0425	Belongs to the sulfur carrier protein TusA family
HPK19_RS14290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_RS14290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK19_RS14295	COG0425	Belongs to the sulfur carrier protein TusA family
HPK19_RS14295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK19_RS14305	COG2210	Belongs to the sulfur carrier protein TusA family
HPK19_RS14310	COG1937	Protein conserved in bacteria
HPK19_RS14320	COG3048	D-serine ammonia-lyase activity
HPK19_RS14325	COG2059	Chromate
HPK19_RS14335	COG0531	amino acid
HPK19_RS14355	COG1929	Belongs to the glycerate kinase type-1 family
HPK19_RS14360	COG1554	hydrolase, family 65, central catalytic
HPK19_RS14365	COG0673	inositol 2-dehydrogenase activity
HPK19_RS14370	COG1082	Xylose isomerase domain protein TIM barrel
HPK19_RS14375	COG1063	alcohol dehydrogenase
HPK19_RS14380	COG0395	ABC-type sugar transport system, permease component
HPK19_RS14385	COG1175	transmembrane transport
HPK19_RS14390	COG1653	transport
HPK19_RS14395	COG0366	Alpha amylase catalytic
HPK19_RS14400	COG1609	Transcriptional regulator
HPK19_RS14405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPK19_RS14415	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPK19_RS14425	COG0586	Pfam SNARE associated Golgi protein
HPK19_RS14430	COG5002	protein histidine kinase activity
HPK19_RS14430	COG3850	Histidine kinase
HPK19_RS14435	COG0745	RESPONSE REGULATOR receiver
HPK19_RS14440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPK19_RS14470	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HPK19_RS14475	COG1309	transcriptional regulator
HPK19_RS14490	COG2801	Transposase and inactivated derivatives
HPK19_RS14500	COG0456	acetyltransferase
HPK19_RS14505	COG1846	Transcriptional regulator
HPK19_RS14510	COG2153	protein acetylation
HPK19_RS14515	COG2364	Membrane
HPK19_RS14520	COG2890	protein-(glutamine-N5) methyltransferase activity
HPK19_RS14535	COG1404	Belongs to the peptidase S8 family
HPK19_RS14560	COG1404	Belongs to the peptidase S8 family
HPK19_RS14570	COG1404	Belongs to the peptidase S8 family
HPK19_RS14575	COG4126	flavin adenine dinucleotide binding
HPK19_RS14610	COG2323	membrane
HPK19_RS14620	COG1404	Belongs to the peptidase S8 family
HPK19_RS14625	COG1404	Belongs to the peptidase S8 family
HPK19_RS14635	COG1113	amino acid transport
HPK19_RS14640	COG1114	Component of the transport system for branched-chain amino acids
HPK19_RS14645	COG5522	Integral membrane protein (intg_mem_TP0381)
HPK19_RS14650	COG3588	fructose-bisphosphate aldolase
HPK19_RS14660	COG2814	Major facilitator Superfamily
HPK19_RS14665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPK19_RS14670	COG0590	tRNA wobble adenosine to inosine editing
HPK19_RS14675	COG1953	Uracil, thiamine, allantoin
HPK19_RS14680	COG0549	Belongs to the carbamate kinase family
HPK19_RS14690	COG1304	FMN binding
HPK19_RS14695	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPK19_RS14705	COG2508	Transcriptional regulator
HPK19_RS14725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK19_RS14730	COG0697	spore germination
HPK19_RS14735	COG1522	sequence-specific DNA binding
HPK19_RS14740	COG0288	reversible hydration of carbon dioxide
HPK19_RS14760	COG2329	Antibiotic biosynthesis monooxygenase
HPK19_RS14785	COG2718	Belongs to the UPF0229 family
HPK19_RS14790	COG4989	oxidoreductase activity
HPK19_RS14795	COG2766	serine protein kinase
HPK19_RS14800	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPK19_RS14810	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPK19_RS14915	COG1285	pathogenesis
HPK19_RS14920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPK19_RS14935	COG2155	Conserved Protein
HPK19_RS14940	COG1098	S1 RNA binding domain
HPK19_RS14945	COG2267	carboxylic ester hydrolase activity
HPK19_RS14950	COG5002	protein histidine kinase activity
HPK19_RS14955	COG0745	RESPONSE REGULATOR receiver
HPK19_RS14975	COG5018	Exonuclease
HPK19_RS14980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPK19_RS14990	COG2050	protein possibly involved in aromatic compounds catabolism
HPK19_RS15000	COG3584	3D domain protein
HPK19_RS15015	COG1252	NADH dehydrogenase
HPK19_RS15025	COG0316	Belongs to the HesB IscA family
HPK19_RS15030	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPK19_RS15040	COG1252	NADH dehydrogenase
HPK19_RS15055	COG4837	Protein of unknown function (DUF1462)
HPK19_RS15060	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HPK19_RS15065	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPK19_RS15070	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPK19_RS15075	COG0647	UMP catabolic process
HPK19_RS15080	COG2445	Protein of unknown function DUF86
HPK19_RS15090	COG4470	Protein conserved in bacteria
HPK19_RS15100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPK19_RS15105	COG0739	heme binding
HPK19_RS15120	COG3377	Domain of unknown function (DUF1805)
HPK19_RS15125	COG0737	Belongs to the 5'-nucleotidase family
HPK19_RS15130	COG0730	response to heat
HPK19_RS15140	COG1404	Belongs to the peptidase S8 family
HPK19_RS15145	COG0719	Fe-S assembly protein
HPK19_RS15150	COG0822	iron-sulfur transferase activity
HPK19_RS15155	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPK19_RS15160	COG0719	Fe-S assembly protein
HPK19_RS15165	COG0396	ATPase activity
HPK19_RS15180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPK19_RS15195	COG1696	Membrane protein involved in D-alanine export
HPK19_RS15200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPK19_RS15205	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HPK19_RS15210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPK19_RS15215	COG1464	Belongs to the NlpA lipoprotein family
HPK19_RS15220	COG2011	ABC-type metal ion transport system permease component
HPK19_RS15225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPK19_RS15235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPK19_RS15240	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HPK19_RS15245	COG0509	glycine decarboxylation via glycine cleavage system
HPK19_RS15250	COG1393	Belongs to the ArsC family
HPK19_RS15255	COG1960	acyl-CoA dehydrogenase activity
HPK19_RS15260	COG0183	Belongs to the thiolase family
HPK19_RS15265	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPK19_RS15265	COG1024	Enoyl-CoA hydratase
HPK19_RS15275	COG0506	proline dehydrogenase activity
HPK19_RS15285	COG2116	formate transmembrane transporter activity
HPK19_RS15290	COG2755	lipolytic protein G-D-S-L family
HPK19_RS15295	COG1131	(ABC) transporter
HPK19_RS15300	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPK19_RS15305	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPK19_RS15320	COG3844	kynureninase activity
HPK19_RS15335	COG1131	(ABC) transporter
HPK19_RS15355	COG1131	(ABC) transporter
HPK19_RS15370	COG1611	Belongs to the LOG family
HPK19_RS15375	COG0673	inositol 2-dehydrogenase activity
HPK19_RS15390	COG0488	(ABC) transporter
HPK19_RS15400	COG0024	Methionine aminopeptidase
HPK19_RS15420	COG1971	Probably functions as a manganese efflux pump
HPK19_RS15425	COG0805	protein transport
HPK19_RS15430	COG1120	ATPase activity
HPK19_RS15435	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK19_RS15440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK19_RS15445	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HPK19_RS15450	COG3853	Toxic anion resistance protein (TelA)
HPK19_RS15465	COG2310	stress, protein
HPK19_RS15470	COG2310	stress, protein
HPK19_RS15485	COG0701	Predicted permease
HPK19_RS15490	COG3689	TIGRFAM TIGR03943 family protein
HPK19_RS15505	COG4549	nuclear export factor GLE1
HPK19_RS15520	COG3546	catalase activity
HPK19_RS15535	COG1231	oxidoreductase activity
HPK19_RS15540	COG0346	lactoylglutathione lyase activity
HPK19_RS15545	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPK19_RS15550	COG4988	ABC transporter
HPK19_RS15555	COG1294	oxidase, subunit
HPK19_RS15560	COG1271	oxidase subunit
HPK19_RS15565	COG2059	Chromate
HPK19_RS15570	COG2059	Chromate
HPK19_RS15580	COG4608	Belongs to the ABC transporter superfamily
HPK19_RS15585	COG0444	Belongs to the ABC transporter superfamily
HPK19_RS15605	COG1522	sequence-specific DNA binding
HPK19_RS15610	COG1511	domain protein
HPK19_RS15620	COG1115	amino acid carrier protein
HPK19_RS15625	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_RS15630	COG2814	Major facilitator Superfamily
HPK19_RS15635	COG1309	transcriptional regulator
HPK19_RS15645	COG1404	Belongs to the peptidase S8 family
HPK19_RS15720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPK19_RS15725	COG0557	exoribonuclease II activity
HPK19_RS15730	COG1647	Serine aminopeptidase, S33
HPK19_RS15735	COG2318	DinB family
HPK19_RS15745	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPK19_RS15770	COG0248	Ppx GppA phosphatase
HPK19_RS15790	COG0149	triose-phosphate isomerase activity
HPK19_RS15795	COG0126	phosphoglycerate kinase activity
HPK19_RS15800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPK19_RS15815	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPK19_RS15820	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HPK19_RS15820	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPK19_RS15830	COG1486	melibiose metabolic process
HPK19_RS15835	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPK19_RS15840	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_RS15850	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPK19_RS15855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_RS15880	COG2723	6-phospho-beta-galactosidase activity
HPK19_RS15890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK19_RS15895	COG1481	regulation of sporulation
HPK19_RS15900	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPK19_RS15910	COG1051	belongs to the nudix hydrolase family
HPK19_RS15915	COG0492	ferredoxin-NADP+ reductase activity
HPK19_RS15925	COG0110	maltose O-acetyltransferase activity
HPK19_RS15935	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPK19_RS15940	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPK19_RS15945	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HPK19_RS15950	COG1950	PFAM Membrane protein of
HPK19_RS15960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPK19_RS15965	COG0556	nucleotide-excision repair
HPK19_RS15980	COG1131	(ABC) transporter
HPK19_RS15985	COG1725	Transcriptional regulator
HPK19_RS16000	COG1595	DNA-templated transcription, initiation
HPK19_RS16005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPK19_RS16010	COG0400	carboxylic ester hydrolase activity
HPK19_RS16015	COG0346	lactoylglutathione lyase activity
HPK19_RS16040	COG2217	Heavy metal translocating P-type atpase
HPK19_RS16050	COG0492	ferredoxin-NADP+ reductase activity
HPK19_RS16080	COG2910	NAD(P)H-binding
HPK19_RS16085	COG1959	2 iron, 2 sulfur cluster binding
HPK19_RS16095	COG1522	sequence-specific DNA binding
HPK19_RS16105	COG0346	lactoylglutathione lyase activity
HPK19_RS16110	COG0431	NADPH-dependent FMN reductase
HPK19_RS16115	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPK19_RS16120	COG2197	response regulator
HPK19_RS16125	COG2203	Gaf domain
HPK19_RS16125	COG4585	Histidine kinase
HPK19_RS16135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK19_RS16150	COG3186	Phenylalanine-4-hydroxylase
HPK19_RS16160	COG1268	BioY protein
HPK19_RS16180	COG0745	RESPONSE REGULATOR receiver
HPK19_RS16185	COG2205	protein histidine kinase activity
HPK19_RS16190	COG0577	efflux transmembrane transporter activity
HPK19_RS16195	COG1136	(ABC) transporter
HPK19_RS16200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HPK19_RS16205	COG1024	Enoyl-CoA hydratase
HPK19_RS16210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPK19_RS16220	COG0439	Biotin carboxylase
HPK19_RS16225	COG1960	acyl-CoA dehydrogenase activity
HPK19_RS16235	COG1309	transcriptional regulator
HPK19_RS16250	COG0352	thiamine-phosphate diphosphorylase activity
HPK19_RS16255	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HPK19_RS16265	COG0351	phosphomethylpyrimidine kinase
HPK19_RS16275	COG0672	)-iron permease
HPK19_RS16280	COG1011	Hydrolase
HPK19_RS16305	COG0133	tryptophan synthase activity
HPK19_RS16310	COG0135	phosphoribosylanthranilate isomerase activity
HPK19_RS16315	COG0134	indole-3-glycerol-phosphate synthase activity
HPK19_RS16320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPK19_RS16325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPK19_RS16325	COG0512	Glutamine amidotransferase of anthranilate synthase
HPK19_RS16330	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPK19_RS16335	COG0697	spore germination
HPK19_RS16350	COG1392	Phosphate transport regulator
HPK19_RS16360	COG0300	oxidoreductase activity
HPK19_RS16365	COG0583	DNA-binding transcription factor activity
HPK19_RS16375	COG2252	PERMEase
HPK19_RS16380	COG1187	pseudouridine synthase activity
HPK19_RS16390	COG1404	Belongs to the peptidase S8 family
HPK19_RS16400	COG0246	Mannitol dehydrogenase
HPK19_RS16405	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK19_RS16410	COG3711	transcriptional antiterminator
HPK19_RS16420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPK19_RS16425	COG3409	Peptidoglycan-binding domain 1 protein
HPK19_RS16425	COG0793	Belongs to the peptidase S41A family
HPK19_RS16430	COG0753	catalase activity
HPK19_RS16435	COG0739	heme binding
HPK19_RS16440	COG2177	Part of the ABC transporter FtsEX involved in
HPK19_RS16445	COG2884	Cell division ATP-binding protein ftsE
HPK19_RS16455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPK19_RS16475	COG1278	Cold shock
HPK19_RS16480	COG0531	amino acid
HPK19_RS16490	COG1040	competence protein
HPK19_RS16495	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HPK19_RS16500	COG1307	EDD domain protein, DegV family
HPK19_RS16505	COG2197	response regulator
HPK19_RS16515	COG1316	TRANSCRIPTIONal
HPK19_RS16520	COG1739	Uncharacterized protein family UPF0029
HPK19_RS16525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPK19_RS16540	COG0741	lytic transglycosylase activity
HPK19_RS16555	COG0653	protein targeting
HPK19_RS16615	COG1316	TRANSCRIPTIONal
HPK19_RS16630	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPK19_RS16645	COG1132	(ABC) transporter
HPK19_RS16650	COG1396	sequence-specific DNA binding
HPK19_RS16655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPK19_RS16660	COG0110	maltose O-acetyltransferase activity
HPK19_RS16665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPK19_RS16675	COG1216	Glycosyl transferase, family 2
HPK19_RS16680	COG1215	transferase activity, transferring glycosyl groups
HPK19_RS16685	COG0297	glycogen (starch) synthase activity
HPK19_RS16685	COG0438	transferase activity, transferring glycosyl groups
HPK19_RS16690	COG1216	Glycosyl transferase, family 2
HPK19_RS16690	COG1442	glycosyl transferase family 8
HPK19_RS16695	COG0463	Glycosyl transferase, family 2
HPK19_RS16705	COG0438	transferase activity, transferring glycosyl groups
HPK19_RS16715	COG0489	protein tyrosine kinase activity
HPK19_RS16720	COG3944	biosynthesis protein
HPK19_RS16750	COG1329	Transcriptional regulator
HPK19_RS16765	COG4715	Zinc finger, swim domain protein
HPK19_RS16770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPK19_RS16775	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPK19_RS16775	COG0456	acetyltransferase
HPK19_RS16780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPK19_RS16795	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPK19_RS16805	COG0697	spore germination
HPK19_RS16810	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPK19_RS16820	COG1609	Transcriptional regulator
HPK19_RS16825	COG0739	heme binding
HPK19_RS16830	COG4166	transmembrane transport
HPK19_RS16835	COG2385	sporulation resulting in formation of a cellular spore
HPK19_RS16850	COG4836	Membrane
HPK19_RS16855	COG1007	ATP synthesis coupled electron transport
HPK19_RS16860	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPK19_RS16865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPK19_RS16870	COG0713	ATP synthesis coupled electron transport
HPK19_RS16875	COG0839	Belongs to the complex I subunit 6 family
HPK19_RS16890	COG0649	NAD binding
HPK19_RS16895	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPK19_RS16900	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPK19_RS16905	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPK19_RS16910	COG2814	Major facilitator Superfamily
HPK19_RS16915	COG1566	PFAM secretion protein HlyD family protein
HPK19_RS16920	COG1309	transcriptional regulator
HPK19_RS16925	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPK19_RS16935	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPK19_RS16940	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPK19_RS16945	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPK19_RS16955	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPK19_RS16960	COG0356	it plays a direct role in the translocation of protons across the membrane
HPK19_RS16975	COG1404	Belongs to the peptidase S8 family
HPK19_RS16985	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPK19_RS16995	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPK19_RS17000	COG2390	Transcriptional regulator
HPK19_RS17005	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPK19_RS17025	COG0698	ribose 5-phosphate isomerase
HPK19_RS17040	COG0009	L-threonylcarbamoyladenylate synthase
HPK19_RS17055	COG0189	ligase activity
HPK19_RS17065	COG2890	protein-(glutamine-N5) methyltransferase activity
HPK19_RS17070	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPK19_RS17075	COG1435	thymidine kinase activity
HPK19_RS17085	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPK19_RS17090	COG1494	fructose-1,6-bisphosphatase
HPK19_RS17110	COG4821	SIS domain
HPK19_RS17115	COG0504	CTP synthase activity
HPK19_RS17120	COG3343	RNA polymerase activity
HPK19_RS17125	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HPK19_RS17125	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HPK19_RS17125	COG1703	isobutyryl-CoA mutase activity
HPK19_RS17130	COG1960	acyl-CoA dehydrogenase activity
HPK19_RS17135	COG0183	Belongs to the thiolase family
HPK19_RS17140	COG2181	nitrate reductase activity
HPK19_RS17140	COG0247	lactate metabolic process
HPK19_RS17145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPK19_RS17165	COG1191	sigma factor activity
HPK19_RS17190	COG2814	Major facilitator Superfamily
HPK19_RS17195	COG0789	Transcriptional regulator
HPK19_RS17210	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HPK19_RS17215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPK19_RS17225	COG1994	Peptidase M50
HPK19_RS17235	COG1078	dGTPase activity
HPK19_RS17240	COG4844	belongs to the
HPK19_RS17250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPK19_RS17255	COG0095	Lipoate-protein ligase
HPK19_RS17260	COG0280	phosphate acetyltransferase
HPK19_RS17270	COG3773	Cell wall hydrolase
HPK19_RS17280	COG2363	Small membrane protein
HPK19_RS17290	COG0561	phosphatase activity
HPK19_RS17295	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPK19_RS17300	COG2855	membrane
HPK19_RS17305	COG0463	Glycosyl transferase, family 2
HPK19_RS17320	COG1131	(ABC) transporter
HPK19_RS17340	COG0551	DNA topoisomerase type I activity
HPK19_RS17340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPK19_RS17345	COG1376	ErfK ybiS ycfS ynhG family protein
HPK19_RS17355	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPK19_RS17360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPK19_RS17365	COG2188	Transcriptional regulator
HPK19_RS17370	COG0366	Alpha amylase catalytic
HPK19_RS17375	COG1263	PTS System
HPK19_RS17375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK19_RS17420	COG0720	synthase
HPK19_RS17430	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPK19_RS17435	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HPK19_RS17440	COG1309	transcriptional regulator
HPK19_RS17450	COG0745	RESPONSE REGULATOR receiver
HPK19_RS17455	COG0642	Histidine kinase
HPK19_RS17460	COG1136	(ABC) transporter
HPK19_RS17465	COG0577	efflux transmembrane transporter activity
HPK19_RS17475	COG2879	small protein
HPK19_RS17480	COG1966	Carbon starvation protein
HPK19_RS17485	COG1309	transcriptional regulator
HPK19_RS17490	COG2814	Major facilitator Superfamily
HPK19_RS17500	COG3507	Belongs to the glycosyl hydrolase 43 family
HPK19_RS17505	COG0667	Aldo Keto reductase
HPK19_RS17510	COG1070	Carbohydrate kinase
HPK19_RS17520	COG2017	converts alpha-aldose to the beta-anomer
HPK19_RS17525	COG5578	integral membrane protein
HPK19_RS17530	COG0395	ABC-type sugar transport system, permease component
HPK19_RS17545	COG2207	Transcriptional regulator
HPK19_RS17545	COG4753	response regulator
HPK19_RS17550	COG2972	Histidine kinase
HPK19_RS17560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK19_RS17560	COG1263	PTS System
HPK19_RS17590	COG3973	AAA domain
HPK19_RS17595	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPK19_RS17615	COG2222	sugar isomerase
HPK19_RS17620	COG2188	Transcriptional regulator
HPK19_RS17625	COG0673	inositol 2-dehydrogenase activity
HPK19_RS17630	COG0395	ABC-type sugar transport system, permease component
HPK19_RS17635	COG1175	transmembrane transport
HPK19_RS17645	COG0579	oxidoreductase
HPK19_RS17660	COG5002	protein histidine kinase activity
HPK19_RS17680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK19_RS17680	COG1263	PTS System
HPK19_RS17700	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPK19_RS17710	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HPK19_RS17715	COG4853	Protein conserved in bacteria
HPK19_RS17720	COG4863	YycH protein
HPK19_RS17725	COG5002	protein histidine kinase activity
HPK19_RS17730	COG0745	RESPONSE REGULATOR receiver
HPK19_RS17755	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPK19_RS17760	COG0305	Participates in initiation and elongation during chromosome replication
HPK19_RS17765	COG0359	binds to the 23S rRNA
HPK19_RS17770	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HPK19_RS17790	COG0360	Binds together with S18 to 16S ribosomal RNA
HPK19_RS17795	COG0012	GTP binding
HPK19_RS17800	COG4481	Protein conserved in bacteria
HPK19_RS17805	COG0668	transmembrane transport
HPK19_RS17815	COG1475	DNA binding
HPK19_RS17820	COG1192	Involved in chromosome partitioning
HPK19_RS17835	COG0445	tRNA wobble uridine modification
HPK19_RS17840	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPK19_RS17845	COG1847	R3H domain protein
HPK19_RS17860	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPK19_RS17865	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPK19_RS17870	COG0592	DNA-directed DNA polymerase activity
HPK19_RS17875	COG2501	S4 domain
HPK19_RS17885	COG0187	DNA topoisomerase II activity
HPK19_RS17890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPK19_RS17910	COG1132	(ABC) transporter
HPK19_RS17915	COG0745	RESPONSE REGULATOR receiver
HPK19_RS17920	COG5002	protein histidine kinase activity
HPK19_RS17945	COG0517	IMP dehydrogenase activity
HPK19_RS17945	COG0516	GMP reductase activity
HPK19_RS17955	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HPK19_RS17960	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HPK19_RS17965	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPK19_RS17975	COG1428	Deoxynucleoside kinase
HPK19_RS17980	COG1428	Deoxynucleoside kinase
HPK19_RS17985	COG1335	isochorismatase
HPK19_RS17990	COG0590	tRNA wobble adenosine to inosine editing
HPK19_RS18000	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPK19_RS18005	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPK19_RS18010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPK19_RS18055	COG1982	Orn Lys Arg decarboxylase major
HPK19_RS18060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPK19_RS18065	COG0470	DNA polymerase III
HPK19_RS18070	COG1774	PSP1 C-terminal conserved region
HPK19_RS18075	COG4467	Involved in initiation control of chromosome replication
HPK19_RS18080	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HPK19_RS18085	COG2827	Endonuclease containing a URI domain
HPK19_RS18090	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPK19_RS18095	COG2002	toxin-antitoxin pair type II binding
HPK19_RS18100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPK19_RS18100	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPK19_RS18105	COG0084	hydrolase, TatD family'
HPK19_RS18110	COG3584	3D domain protein
HPK19_RS18110	COG3583	domain protein
HPK19_RS18130	COG4466	Protein conserved in bacteria
HPK19_RS18145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPK19_RS18150	COG0251	oxidation-reduction process
HPK19_RS18155	COG2088	sporulation resulting in formation of a cellular spore
HPK19_RS18160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPK19_RS18180	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPK19_RS18185	COG2002	toxin-antitoxin pair type II binding
HPK19_RS18190	COG2244	polysaccharide biosynthetic process
HPK19_RS18195	COG3956	TIGRFAM MazG family protein
HPK19_RS18200	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPK19_RS18220	COG1098	S1 RNA binding domain
HPK19_RS18235	COG2208	phosphoserine phosphatase activity
HPK19_RS18240	COG2304	oxidoreductase activity
HPK19_RS18245	COG0515	serine threonine protein kinase
HPK19_RS18260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPK19_RS18275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPK19_RS18280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPK19_RS18285	COG0512	Glutamine amidotransferase of anthranilate synthase
HPK19_RS18290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPK19_RS18295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPK19_RS18300	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPK19_RS18305	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPK19_RS18310	COG1396	sequence-specific DNA binding
HPK19_RS18315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPK19_RS18320	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPK19_RS18415	COG3880	PFAM UvrB UvrC protein
HPK19_RS18420	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HPK19_RS18425	COG0542	response to heat
HPK19_RS18430	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPK19_RS18440	COG4956	integral membrane protein (PIN domain superfamily)
HPK19_RS18445	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPK19_RS18450	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPK19_RS18455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPK19_RS18460	COG1045	serine acetyltransferase
HPK19_RS18465	COG0215	cysteine-tRNA ligase activity
HPK19_RS18475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPK19_RS18480	COG3688	RNA-binding protein containing a PIN domain
HPK19_RS18495	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPK19_RS18500	COG0250	Participates in transcription elongation, termination and antitermination
HPK19_RS18505	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPK19_RS18510	COG0081	regulation of translation
HPK19_RS18515	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPK19_RS18520	COG0222	ribosome binding
HPK19_RS18525	COG2813	Specifically methylates the guanine in position
HPK19_RS18545	COG0049	tRNA binding
HPK19_RS18555	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPK19_RS18560	COG0051	transcription antitermination factor activity, RNA binding
HPK19_RS18565	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPK19_RS18570	COG0088	Forms part of the polypeptide exit tunnel
HPK19_RS18575	COG0089	rRNA binding
HPK19_RS18590	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPK19_RS18595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPK19_RS18610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPK19_RS18615	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPK19_RS18630	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPK19_RS18640	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPK19_RS18645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPK19_RS18650	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPK19_RS18655	COG1841	ribosomal large subunit assembly
HPK19_RS18665	COG0201	protein transport
HPK19_RS18670	COG0563	adenylate kinase activity
HPK19_RS18680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPK19_RS18685	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPK19_RS18715	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPK19_RS18720	COG0101	tRNA pseudouridine synthase activity
HPK19_RS18725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPK19_RS18740	COG1027	Aspartate ammonia-lyase
HPK19_RS18745	COG0281	malic enzyme
HPK19_RS18750	COG4191	Histidine kinase
HPK19_RS18755	COG0784	Response regulator, receiver
HPK19_RS18775	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPK19_RS18780	COG0489	protein tyrosine kinase activity
HPK19_RS18785	COG2194	sulfuric ester hydrolase activity
HPK19_RS18790	COG0726	polysaccharide deacetylase
HPK19_RS18865	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HPK19_RS18875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPK19_RS18885	COG0697	spore germination
HPK19_RS18910	COG0745	RESPONSE REGULATOR receiver
HPK19_RS18915	COG5002	protein histidine kinase activity
HPK19_RS18920	COG1803	Methylglyoxal synthase
HPK19_RS18930	COG1733	regulation of RNA biosynthetic process
HPK19_RS18935	COG2814	Major facilitator Superfamily
HPK19_RS18940	COG0656	L-ascorbic acid biosynthetic process
HPK19_RS18945	COG2801	Transposase and inactivated derivatives
HPK19_RS18970	COG2259	Doxx family
HPK19_RS18985	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPK19_RS18990	COG0019	diaminopimelate decarboxylase activity
HPK19_RS18995	COG0791	NLP P60 protein
HPK19_RS18995	COG1388	LysM domain
HPK19_RS19000	COG1970	mechanosensitive ion channel activity
HPK19_RS19005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPK19_RS19005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPK19_RS19020	COG1181	Belongs to the D-alanine--D-alanine ligase family
HPK19_RS19025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPK19_RS19030	COG0513	Belongs to the DEAD box helicase family
HPK19_RS19035	COG4294	response to UV
HPK19_RS19045	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPK19_RS19050	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPK19_RS19055	COG0864	Transcriptional regulator
HPK19_RS19060	COG2337	Toxic component of a toxin-antitoxin (TA) module
HPK19_RS19065	COG2183	response to ionizing radiation
HPK19_RS19075	COG3091	SprT-like family
HPK19_RS19175	COG0802	atpase or kinase
HPK19_RS19180	COG1214	PFAM Peptidase M22, glycoprotease
HPK19_RS19185	COG0456	acetyltransferase
HPK19_RS19190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPK19_RS19195	COG0488	(ABC) transporter
HPK19_RS19205	COG1266	CAAX protease self-immunity
HPK19_RS19210	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPK19_RS19215	COG0459	protein refolding
HPK19_RS19225	COG0582	viral genome integration into host DNA
HPK19_RS19230	COG3620	sequence-specific DNA binding
HPK19_RS19250	COG3646	Phage regulatory protein
HPK19_RS19250	COG3645	SOS response
HPK19_RS19300	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HPK19_RS19350	COG1802	Transcriptional regulator
HPK19_RS19350	COG4626	Terminase
HPK19_RS19420	COG5280	Phage tail tape measure protein TP901
HPK19_RS19420	COG3953	SLT domain
HPK19_RS19450	COG5632	N-Acetylmuramoyl-L-alanine amidase
HPK19_RS19510	COG0739	heme binding
HPK19_RS19535	COG5632	N-Acetylmuramoyl-L-alanine amidase
HPK19_RS19540	COG2076	Multidrug Resistance protein
HPK19_RS19570	COG2252	PERMEase
HPK19_RS19610	COG1193	negative regulation of DNA recombination
HPK19_RS19615	COG2226	methyltransferase
HPK19_RS19630	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_RS19635	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_RS19640	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPK19_RS19645	COG3711	transcriptional antiterminator
HPK19_RS19645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK19_RS19715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK19_RS19725	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPK19_RS19730	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPK19_RS19735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPK19_RS19740	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPK19_RS19745	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPK19_RS19750	COG0047	phosphoribosylformylglycinamidine synthase activity
HPK19_RS19760	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPK19_RS19765	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPK19_RS19770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPK19_RS19780	COG0151	Belongs to the GarS family
HPK19_RS19790	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HPK19_RS19795	COG0210	DNA helicase
HPK19_RS19805	COG4851	CamS sex pheromone cAM373 precursor
HPK19_RS19810	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_RS19820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPK19_RS19830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPK19_RS19835	COG2116	formate transmembrane transporter activity
HPK19_RS19840	COG1597	lipid kinase activity
HPK19_RS19850	COG1404	Belongs to the peptidase S8 family
HPK19_RS19850	COG4412	M6 family metalloprotease domain protein
HPK19_RS19870	COG4821	SIS domain
HPK19_RS19885	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_RS19895	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_RS19900	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPK19_RS19905	COG1486	melibiose metabolic process
HPK19_RS19915	COG0531	amino acid
HPK19_RS19920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPK19_RS19935	COG1414	Transcriptional regulator
HPK19_RS19950	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_RS19955	COG0028	Belongs to the TPP enzyme family
HPK19_RS19965	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HPK19_RS19970	COG4638	Rieske (2fe-2S)
HPK19_RS19980	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_RS19995	COG1657	PFAM Prenyltransferase squalene oxidase
HPK19_RS20000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPK19_RS20005	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPK19_RS20010	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPK19_RS20015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPK19_RS20020	COG0456	acetyltransferase
HPK19_RS20025	COG3829	transcription factor binding
HPK19_RS20030	COG1509	lysine 2,3-aminomutase activity
HPK19_RS20040	COG0833	amino acid
HPK19_RS20050	COG3711	transcriptional antiterminator
HPK19_RS20055	COG1263	PTS System
HPK19_RS20055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK19_RS20055	COG2190	(PTS) system
HPK19_RS20070	COG0531	amino acid
HPK19_RS20075	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPK19_RS20090	COG3829	transcription factor binding
HPK19_RS20090	COG3290	protein histidine kinase activity
HPK19_RS20095	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_RS20105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPK19_RS20110	COG1012	belongs to the aldehyde dehydrogenase family
HPK19_RS20115	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPK19_RS20120	COG1960	acyl-CoA dehydrogenase activity
HPK19_RS20150	COG1294	oxidase, subunit
HPK19_RS20155	COG1271	oxidase subunit
HPK19_RS20165	COG0492	ferredoxin-NADP+ reductase activity
HPK19_RS20170	COG1120	ATPase activity
HPK19_RS20175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPK19_RS20180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK19_RS20185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK19_RS20190	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPK19_RS20195	COG2199	diguanylate cyclase activity
HPK19_RS20195	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPK19_RS20235	COG1876	peptidase activity
HPK19_RS20245	COG1404	Belongs to the peptidase S8 family
HPK19_RS20250	COG2755	lipolytic protein G-D-S-L family
HPK19_RS20250	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HPK19_RS20260	COG1595	DNA-templated transcription, initiation
HPK19_RS20265	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HPK19_RS20270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK19_RS20290	COG0534	Mate efflux family protein
HPK19_RS20295	COG1271	oxidase subunit
HPK19_RS20300	COG1294	oxidase, subunit
HPK19_RS20305	COG1126	abc transporter atp-binding protein
HPK19_RS20310	COG0765	amino acid transport
HPK19_RS20315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK19_RS20330	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HPK19_RS20340	COG3852	Histidine kinase
HPK19_RS20345	COG1408	metallophosphoesterase
HPK19_RS20380	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPK19_RS20385	COG1609	Transcriptional regulator
HPK19_RS20390	COG0077	Prephenate dehydratase
HPK19_RS20400	COG3829	transcription factor binding
HPK19_RS20405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPK19_RS20410	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPK19_RS20415	COG0833	amino acid
HPK19_RS20425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPK19_RS20430	COG0601	transmembrane transport
HPK19_RS20435	COG4608	Belongs to the ABC transporter superfamily
HPK19_RS20445	COG0783	Belongs to the Dps family
HPK19_RS20455	COG3859	Proton-coupled thiamine transporter YuaJ
HPK19_RS20460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPK19_RS20470	COG1295	ribonuclease BN
HPK19_RS20475	COG2217	Heavy metal translocating P-type atpase
HPK19_RS20485	COG0697	spore germination
HPK19_RS20505	COG0791	NLP P60 protein
HPK19_RS20505	COG1388	LysM domain
HPK19_RS20510	COG3152	Membrane
HPK19_RS20520	COG3152	Membrane
HPK19_RS20575	COG2972	Histidine kinase
HPK19_RS20580	COG4753	response regulator
HPK19_RS20580	COG2207	Transcriptional regulator
HPK19_RS20585	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPK19_RS20595	COG0745	RESPONSE REGULATOR receiver
HPK19_RS20605	COG3944	biosynthesis protein
HPK19_RS20610	COG0489	protein tyrosine kinase activity
HPK19_RS20620	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPK19_RS20625	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPK19_RS20645	COG1216	Glycosyl transferase, family 2
HPK19_RS20650	COG5039	Polysaccharide pyruvyl transferase
HPK19_RS20660	COG0438	transferase activity, transferring glycosyl groups
HPK19_RS20720	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPK19_RS20725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPK19_RS20730	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPK19_RS20735	COG1215	transferase activity, transferring glycosyl groups
HPK19_RS20735	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HPK19_RS20745	COG1215	transferase activity, transferring glycosyl groups
HPK19_RS20745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HPK19_RS20760	COG1216	Glycosyl transferase, family 2
HPK19_RS20760	COG1442	glycosyl transferase family 8
HPK19_RS20765	COG1215	transferase activity, transferring glycosyl groups
HPK19_RS20765	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HPK19_RS20770	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPK19_RS20775	COG1682	transport, permease protein
HPK19_RS20780	COG1134	teichoic acid transport
HPK19_RS20785	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPK19_RS20800	COG3871	stress protein (general stress protein 26)
HPK19_RS20805	COG0387	Pfam Sodium calcium exchanger
HPK19_RS20810	COG2364	Membrane
HPK19_RS20820	COG0535	radical SAM domain protein
HPK19_RS20845	COG1442	glycosyl transferase family 8
HPK19_RS20845	COG1216	Glycosyl transferase, family 2
HPK19_RS20850	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPK19_RS20855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPK19_RS20860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPK19_RS20885	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPK19_RS20895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPK19_RS20900	COG0573	inorganic phosphate transmembrane transporter activity
HPK19_RS20905	COG0581	inorganic phosphate transmembrane transporter activity
HPK19_RS20925	COG5002	protein histidine kinase activity
HPK19_RS20930	COG0745	RESPONSE REGULATOR receiver
HPK19_RS20935	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HPK19_RS20940	COG0463	Glycosyl transferase, family 2
HPK19_RS20950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPK19_RS20955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPK19_RS20965	COG1132	(ABC) transporter
HPK19_RS20970	COG1132	(ABC) transporter
HPK19_RS20975	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPK19_RS20985	COG2972	Histidine kinase
HPK19_RS20990	COG3279	Response regulator of the LytR AlgR family
HPK19_RS21005	COG4214	carbohydrate transport
HPK19_RS21035	COG0277	FAD linked oxidase domain protein
HPK19_RS21040	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPK19_RS21045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPK19_RS21045	COG3153	acetyltransferase
HPK19_RS21050	COG0456	acetyltransferase
HPK19_RS21070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPK19_RS21090	COG1607	acyl-coa hydrolase
HPK19_RS21100	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPK19_RS21105	COG0697	spore germination
HPK19_RS21135	COG2959	enzyme of heme biosynthesis
HPK19_RS21145	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_RS21150	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPK19_RS21155	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPK19_RS21160	COG1486	melibiose metabolic process
HPK19_RS21180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPK19_RS21185	COG1132	(ABC) transporter
HPK19_RS21200	COG0456	acetyltransferase
HPK19_RS21200	COG1846	Transcriptional regulator
HPK19_RS21205	COG0861	Integral membrane protein TerC family
HPK19_RS21220	COG5566	PFAM Mor transcription activator
HPK19_RS21235	COG1473	amidohydrolase
HPK19_RS21265	COG1486	melibiose metabolic process
HPK19_RS21270	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPK19_RS21275	COG2971	BadF BadG BcrA BcrD
HPK19_RS21285	COG1737	Transcriptional regulator
HPK19_RS21290	COG1278	Cold shock
HPK19_RS21300	COG0247	lactate metabolic process
HPK19_RS21305	COG0277	FAD linked oxidase domain protein
HPK19_RS21310	COG3835	regulator
HPK19_RS21320	COG2814	Major facilitator Superfamily
HPK19_RS21325	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HPK19_RS21330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK19_RS21330	COG1263	PTS System
HPK19_RS21335	COG1737	Transcriptional regulator
HPK19_RS21360	COG1737	Transcriptional regulator
HPK19_RS21380	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPK19_RS21390	COG1554	hydrolase, family 65, central catalytic
HPK19_RS21395	COG0346	lactoylglutathione lyase activity
HPK19_RS21405	COG1470	cell adhesion involved in biofilm formation
HPK19_RS21410	COG1357	PFAM Pentapeptide repeats (8 copies)
HPK19_RS21425	COG0697	spore germination
HPK19_RS21445	COG1404	Belongs to the peptidase S8 family
HPK19_RS21455	COG2066	Belongs to the glutaminase family
HPK19_RS21470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPK19_RS21475	COG0628	permease
HPK19_RS21480	COG1368	sulfuric ester hydrolase activity
HPK19_RS21485	COG4548	von Willebrand factor, type A
HPK19_RS21490	COG0714	Associated with various cellular activities
HPK19_RS21500	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPK19_RS21520	COG1228	amidohydrolase
HPK19_RS21525	COG1090	epimerase
HPK19_RS21550	COG1988	membrane-bound metal-dependent
HPK19_RS21555	COG1194	a g-specific adenine glycosylase
HPK19_RS21575	COG3557	Belongs to the UPF0374 family
HPK19_RS21580	COG1132	(ABC) transporter
HPK19_RS21585	COG4129	membrane
HPK19_RS21590	COG0070	glutamate synthase
HPK19_RS21590	COG0069	glutamate synthase activity
HPK19_RS21590	COG0067	glutamate synthase
HPK19_RS21595	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPK19_RS21600	COG4555	ABC transporter
HPK19_RS21620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPK19_RS21625	COG0735	belongs to the Fur family
HPK19_RS21770	COG2169	Transcriptional regulator
HPK19_RS21790	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPK19_RS21795	COG0297	glycogen (starch) synthase activity
HPK19_RS21800	COG0058	SHG alpha-glucan phosphorylase activity
HPK19_RS21825	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPK19_RS21830	COG1575	Belongs to the MenA family. Type 1 subfamily
HPK19_RS21835	COG1169	isochorismate synthase
HPK19_RS21840	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPK19_RS21845	COG0596	Alpha beta hydrolase
HPK19_RS21850	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPK19_RS21855	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_RS21860	COG4948	Mandelate Racemase Muconate Lactonizing
HPK19_RS21865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HPK19_RS21875	COG0494	nUDIX hydrolase
HPK19_RS21880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPK19_RS21885	COG1116	anion transmembrane transporter activity
HPK19_RS21890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPK19_RS21895	COG1959	2 iron, 2 sulfur cluster binding
HPK19_RS21900	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPK19_RS21960	COG1741	Belongs to the pirin family
HPK19_RS21965	COG1765	OsmC-like protein
HPK19_RS21975	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HPK19_RS21985	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HPK19_RS21990	COG0438	transferase activity, transferring glycosyl groups
HPK19_RS21990	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPK19_RS21995	COG0671	phosphoesterase, PA-phosphatase related
HPK19_RS22000	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPK19_RS22010	COG0477	Major facilitator Superfamily
HPK19_RS22015	COG0475	glutathione-regulated potassium exporter activity
HPK19_RS22025	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HPK19_RS22030	COG1242	4 iron, 4 sulfur cluster binding
HPK19_RS22045	COG2814	Major facilitator Superfamily
HPK19_RS22055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK19_RS22065	COG2081	HI0933 family
HPK19_RS22070	COG2244	polysaccharide biosynthetic process
HPK19_RS22075	COG1187	pseudouridine synthase activity
HPK19_RS22080	COG1349	DNA-binding transcription factor activity
HPK19_RS22085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPK19_RS22100	COG1523	belongs to the glycosyl hydrolase 13 family
HPK19_RS22105	COG0510	thiamine kinase activity
HPK19_RS22120	COG2226	methyltransferase
HPK19_RS22130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_RS22140	COG1363	Peptidase, m42
HPK19_RS22150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPK19_RS22155	COG4848	Belongs to the UPF0354 family
HPK19_RS22160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPK19_RS22165	COG1674	ftsk spoiiie
HPK19_RS22175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPK19_RS22185	COG0477	Major facilitator Superfamily
HPK19_RS22190	COG2986	histidine ammonia-lyase
HPK19_RS22195	COG4977	sequence-specific DNA binding
HPK19_RS22220	COG2814	Major facilitator Superfamily
HPK19_RS22225	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HPK19_RS22230	COG1793	dna ligase
HPK19_RS22235	COG1793	dna ligase
HPK19_RS22235	COG3285	dna ligase
HPK19_RS22240	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPK19_RS22255	COG1404	Belongs to the peptidase S8 family
HPK19_RS22265	COG1595	DNA-templated transcription, initiation
HPK19_RS22275	COG3344	reverse transcriptase
HPK19_RS22295	COG0814	amino acid
HPK19_RS22300	COG0454	-acetyltransferase
HPK19_RS22310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPK19_RS22315	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPK19_RS22320	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPK19_RS22325	COG0640	Transcriptional regulator
HPK19_RS22345	COG2378	regulation of single-species biofilm formation
HPK19_RS22350	COG1113	amino acid transport
HPK19_RS22355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK19_RS22370	COG2207	Transcriptional regulator
HPK19_RS22370	COG3708	Transcriptional regulator
HPK19_RS22400	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HPK19_RS22410	COG0492	ferredoxin-NADP+ reductase activity
HPK19_RS22425	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPK19_RS22435	COG0384	phenazine biosynthesis protein PhzF
HPK19_RS22440	COG1078	dGTPase activity
HPK19_RS22450	COG1757	Na H antiporter
HPK19_RS22465	COG1301	dicarboxylic acid transport
HPK19_RS22470	COG1802	Transcriptional regulator
HPK19_RS22485	COG2309	aminopeptidase activity
HPK19_RS22495	COG3118	belongs to the thioredoxin family
HPK19_RS22515	COG1605	Chorismate mutase
HPK19_RS22515	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HPK19_RS22525	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPK19_RS22530	COG0517	IMP dehydrogenase activity
HPK19_RS22535	COG0454	-acetyltransferase
HPK19_RS22540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPK19_RS22550	COG1704	LemA family
HPK19_RS22580	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPK19_RS22585	COG1956	GAF domain-containing protein
HPK19_RS22590	COG1309	transcriptional regulator
HPK19_RS22595	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HPK19_RS22600	COG1104	cysteine desulfurase activity
HPK19_RS22620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPK19_RS22625	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HPK19_RS22635	COG3874	Sporulation protein YtfJ
HPK19_RS22640	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HPK19_RS22645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPK19_RS22650	COG0392	lysyltransferase activity
HPK19_RS22650	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HPK19_RS22655	COG1215	transferase activity, transferring glycosyl groups
HPK19_RS22665	COG0827	DNA restriction-modification system
HPK19_RS22670	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPK19_RS22675	COG2217	Heavy metal translocating P-type atpase
HPK19_RS22685	COG1028	Short-chain dehydrogenase reductase Sdr
HPK19_RS22700	COG0006	proline dipeptidase activity
HPK19_RS22710	COG4109	DRTGG domain
HPK19_RS22725	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPK19_RS22740	COG0587	DNA-directed DNA polymerase activity
HPK19_RS22745	COG0281	malic enzyme
HPK19_RS22755	COG0825	malonyl-CoA metabolic process
HPK19_RS22760	COG0205	6-phosphofructokinase activity
HPK19_RS22780	COG0628	permease
HPK19_RS22790	COG0372	Belongs to the citrate synthase family
HPK19_RS22795	COG0538	isocitrate dehydrogenase activity
HPK19_RS22800	COG0039	L-malate dehydrogenase activity
HPK19_RS22815	COG0745	RESPONSE REGULATOR receiver
HPK19_RS22820	COG5002	protein histidine kinase activity
HPK19_RS22830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPK19_RS22830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPK19_RS22840	COG1971	Probably functions as a manganese efflux pump
HPK19_RS22850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPK19_RS22855	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HPK19_RS22860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPK19_RS22865	COG3611	Membrane attachment protein
HPK19_RS22870	COG1484	DNA-dependent DNA replication
HPK19_RS22890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPK19_RS22900	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HPK19_RS22905	COG1363	Peptidase, m42
HPK19_RS22910	COG4175	Glycine betaine
HPK19_RS22910	COG0517	IMP dehydrogenase activity
HPK19_RS22915	COG2113	Glycine betaine
HPK19_RS22925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPK19_RS22930	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPK19_RS22955	COG1216	Glycosyl transferase, family 2
HPK19_RS22960	COG0457	Tetratricopeptide repeat
HPK19_RS22960	COG0463	Glycosyl transferase, family 2
HPK19_RS22965	COG0457	Tetratricopeptide repeat
HPK19_RS22965	COG0463	Glycosyl transferase, family 2
HPK19_RS22970	COG0018	arginyl-trna synthetase
HPK19_RS22975	COG0778	Nitroreductase
HPK19_RS22980	COG0488	(ABC) transporter
HPK19_RS23010	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPK19_RS23020	COG1286	toxin biosynthetic process
HPK19_RS23025	COG1796	DNA polymerase
HPK19_RS23025	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPK19_RS23030	COG1193	negative regulation of DNA recombination
HPK19_RS23040	COG0456	acetyltransferase
HPK19_RS23070	COG4152	abc transporter atp-binding protein
HPK19_RS23075	COG1668	transmembrane transport
HPK19_RS23095	COG0318	PFAM AMP-dependent synthetase and ligase
HPK19_RS23100	COG1309	transcriptional regulator
HPK19_RS23105	COG1024	Enoyl-CoA hydratase
HPK19_RS23110	COG2086	electron transfer activity
HPK19_RS23115	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HPK19_RS23135	COG3118	belongs to the thioredoxin family
HPK19_RS23140	COG1846	Transcriptional regulator
HPK19_RS23145	COG0477	Major facilitator Superfamily
HPK19_RS23155	COG0322	excinuclease ABC activity
HPK19_RS23170	COG1719	4-vinyl reductase, 4VR
HPK19_RS23175	COG2009	succinate dehydrogenase
HPK19_RS23180	COG1053	succinate dehydrogenase
HPK19_RS23185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPK19_RS23205	COG0824	Thioesterase
HPK19_RS23210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPK19_RS23230	COG1959	2 iron, 2 sulfur cluster binding
HPK19_RS23240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPK19_RS23250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPK19_RS23260	COG0084	hydrolase, TatD family'
HPK19_RS23265	COG2197	response regulator
HPK19_RS23270	COG5401	PFAM Sporulation and spore germination
HPK19_RS23275	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPK19_RS23280	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPK19_RS23285	COG0622	Phosphoesterase
HPK19_RS23305	COG1477	protein flavinylation
HPK19_RS23305	COG0457	Tetratricopeptide repeat
HPK19_RS23310	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPK19_RS23320	COG1067	ATP-dependent peptidase activity
HPK19_RS23320	COG0470	DNA polymerase III
HPK19_RS23340	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPK19_RS23345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPK19_RS23360	COG0113	porphobilinogen synthase activity
HPK19_RS23365	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPK19_RS23370	COG1388	LysM domain
HPK19_RS23370	COG1388	LysM domain
HPK19_RS23375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPK19_RS23380	COG4326	sporulation control protein
HPK19_RS23390	COG0285	dihydrofolate synthase activity
HPK19_RS23395	COG2199	diguanylate cyclase activity
HPK19_RS23415	COG1077	Cell shape determining protein MreB Mrl
HPK19_RS23420	COG1792	Involved in formation and maintenance of cell shape
HPK19_RS23425	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPK19_RS23430	COG0850	regulation of cytokinetic process
HPK19_RS23435	COG2894	cell division
HPK19_RS23440	COG0739	heme binding
HPK19_RS23445	COG1994	Peptidase M50
HPK19_RS23450	COG1216	Glycosyl transferase, family 2
HPK19_RS23455	COG1530	ribonuclease E activity
HPK19_RS23460	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPK19_RS23465	COG2868	ribosomal protein
HPK19_RS23470	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPK19_RS23475	COG3290	protein histidine kinase activity
HPK19_RS23485	COG1827	regulation of RNA biosynthetic process
HPK19_RS23490	COG1104	cysteine desulfurase activity
HPK19_RS23495	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPK19_RS23500	COG0157	Belongs to the NadC ModD family
HPK19_RS23520	COG1309	transcriptional regulator
HPK19_RS23535	COG0667	Aldo Keto reductase
HPK19_RS23550	COG2267	carboxylic ester hydrolase activity
HPK19_RS23590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK19_RS23610	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPK19_RS23620	COG1862	Preprotein translocase
HPK19_RS23630	COG2323	membrane
HPK19_RS23635	COG2244	polysaccharide biosynthetic process
HPK19_RS23645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPK19_RS23645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPK19_RS23650	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPK19_RS23655	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPK19_RS23655	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HPK19_RS23660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPK19_RS23665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPK19_RS23690	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPK19_RS23695	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPK19_RS23715	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPK19_RS23740	COG1404	Belongs to the peptidase S8 family
HPK19_RS23745	COG1959	2 iron, 2 sulfur cluster binding
HPK19_RS23750	COG1104	cysteine desulfurase activity
HPK19_RS23755	COG0482	sulfurtransferase activity
HPK19_RS23765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPK19_RS23780	COG0628	permease
HPK19_RS23790	COG4472	Bacterial protein of unknown function (DUF965)
HPK19_RS23795	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPK19_RS23800	COG3906	Belongs to the UPF0473 family
HPK19_RS23805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPK19_RS23810	COG4122	O-methyltransferase activity
HPK19_RS23835	COG0768	penicillin binding
HPK19_RS23850	COG1131	(ABC) transporter
HPK19_RS23855	COG0842	Transport permease protein
HPK19_RS23855	COG1511	domain protein
HPK19_RS23860	COG1309	transcriptional regulator
HPK19_RS23875	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HPK19_RS23875	COG1605	Chorismate mutase
HPK19_RS23880	COG0287	Prephenate dehydrogenase
HPK19_RS23900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPK19_RS23905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPK19_RS23915	COG2357	RelA SpoT domain protein
HPK19_RS23930	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HPK19_RS23935	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HPK19_RS23945	COG1534	Rna-binding protein
HPK19_RS23950	COG1713	HD superfamily hydrolase involved in NAD metabolism
HPK19_RS23955	COG0799	negative regulation of ribosome biogenesis
HPK19_RS23960	COG2226	methyltransferase
HPK19_RS23965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPK19_RS23975	COG0658	competence protein
HPK19_RS23975	COG2333	competence protein COMEC
HPK19_RS23985	COG1466	dna polymerase III delta subunit
HPK19_RS23995	COG0268	Binds directly to 16S ribosomal RNA
HPK19_RS24010	COG0481	GTPase activity
HPK19_RS24015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPK19_RS24025	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPK19_RS24035	COG0484	heat shock protein binding
HPK19_RS24045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPK19_RS24050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPK19_RS24080	COG2207	Transcriptional regulator
HPK19_RS24085	COG2972	Histidine kinase
HPK19_RS24090	COG4608	Belongs to the ABC transporter superfamily
HPK19_RS24095	COG0444	Belongs to the ABC transporter superfamily
HPK19_RS24110	COG0747	negative chemotaxis
HPK19_RS24115	COG0402	S-adenosylhomocysteine deaminase activity
HPK19_RS24120	COG1228	amidohydrolase
HPK19_RS24130	COG0402	S-adenosylhomocysteine deaminase activity
HPK19_RS24135	COG0402	S-adenosylhomocysteine deaminase activity
HPK19_RS24140	COG0402	S-adenosylhomocysteine deaminase activity
HPK19_RS24150	COG2233	PERMEase
HPK19_RS24155	COG0322	excinuclease ABC activity
HPK19_RS24185	COG0697	spore germination
HPK19_RS24190	COG0531	amino acid
HPK19_RS24200	COG2814	Major facilitator Superfamily
HPK19_RS24205	COG1846	Transcriptional regulator
HPK19_RS24210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPK19_RS24240	COG1404	Belongs to the peptidase S8 family
HPK19_RS24260	COG0697	spore germination
HPK19_RS24275	COG1404	Belongs to the peptidase S8 family
HPK19_RS24295	COG4977	sequence-specific DNA binding
HPK19_RS24315	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPK19_RS24320	COG1228	amidohydrolase
HPK19_RS24330	COG1404	Belongs to the peptidase S8 family
HPK19_RS24335	COG0640	Transcriptional regulator
HPK19_RS24345	COG1846	Transcriptional regulator
HPK19_RS24360	COG1404	Belongs to the peptidase S8 family
HPK19_RS24365	COG1404	Belongs to the peptidase S8 family
HPK19_RS24375	COG1823	symporter activity
HPK19_RS24385	COG2508	Transcriptional regulator
HPK19_RS24390	COG2271	Major facilitator Superfamily
HPK19_RS24395	COG1473	amidohydrolase
HPK19_RS24400	COG1404	Belongs to the peptidase S8 family
HPK19_RS24405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPK19_RS24410	COG0789	Transcriptional regulator
HPK19_RS24415	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPK19_RS24450	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPK19_RS24460	COG2002	toxin-antitoxin pair type II binding
HPK19_RS24470	COG0789	Transcriptional regulator
HPK19_RS24490	COG1404	Belongs to the peptidase S8 family
HPK19_RS24510	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPK19_RS24520	COG0145	ligase activity
HPK19_RS24595	COG3344	reverse transcriptase
HPK19_RS24625	COG1404	Belongs to the peptidase S8 family
HPK19_RS24630	COG1404	Belongs to the peptidase S8 family
HPK19_RS24635	COG1404	Belongs to the peptidase S8 family
HPK19_RS24640	COG1404	Belongs to the peptidase S8 family
HPK19_RS24660	COG3344	reverse transcriptase
HPK19_RS24685	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HPK19_RS24710	COG2204	response regulator
HPK19_RS24715	COG0174	glutamine synthetase
HPK19_RS24725	COG0531	amino acid
HPK19_RS24745	COG0395	ABC-type sugar transport system, permease component
HPK19_RS24755	COG1653	transport
HPK19_RS24760	COG1940	carbohydrate kinase activity
HPK19_RS24765	COG4977	sequence-specific DNA binding
HPK19_RS24765	COG1917	Cupin 2, conserved barrel domain protein
HPK19_RS24770	COG1482	cell wall glycoprotein biosynthetic process
HPK19_RS24785	COG4989	oxidoreductase activity
HPK19_RS24795	COG0531	amino acid
HPK19_RS24805	COG4873	Protein conserved in bacteria
HPK19_RS24810	COG2801	Transposase and inactivated derivatives
HPK19_RS24830	COG4644	lycopene metabolic process
HPK19_RS24880	COG0791	NLP P60 protein
HPK19_RS24880	COG0741	lytic transglycosylase activity
HPK19_RS24940	COG2205	protein histidine kinase activity
HPK19_RS24945	COG1073	alpha beta
HPK19_RS24975	COG0768	penicillin binding
HPK19_RS24985	COG1404	Belongs to the peptidase S8 family
HPK19_RS24990	COG1404	Belongs to the peptidase S8 family
HPK19_RS25060	COG4974	Belongs to the 'phage' integrase family
HPK19_RS25070	COG3773	Cell wall hydrolase
HPK19_RS25080	COG4974	Belongs to the 'phage' integrase family
HPK19_RS25165	COG1078	dGTPase activity
HPK19_RS25210	COG3655	Transcriptional regulator
HPK19_RS25215	COG3858	chitin binding
HPK19_RS25215	COG1388	LysM domain
HPK19_RS25315	COG1404	Belongs to the peptidase S8 family
HPK19_RS25325	COG0659	secondary active sulfate transmembrane transporter activity
HPK19_RS25330	COG0288	reversible hydration of carbon dioxide
HPK19_RS25365	COG0531	amino acid
HPK19_RS25390	COG2267	carboxylic ester hydrolase activity
HPK19_RS25420	COG1404	Belongs to the peptidase S8 family
HPK19_RS25445	COG1404	Belongs to the peptidase S8 family
HPK19_RS25470	COG1404	Belongs to the peptidase S8 family
HPK19_RS25490	COG0776	regulation of translation
HPK19_RS25505	COG3773	Cell wall hydrolase
HPK19_RS25540	COG2003	Belongs to the UPF0758 family
HPK19_RS25555	COG2814	Major facilitator Superfamily
HPK19_RS25560	COG1846	Transcriptional regulator
HPK19_RS25575	COG0778	Nitroreductase
HPK19_RS25585	COG0577	efflux transmembrane transporter activity
HPK19_RS25590	COG1136	(ABC) transporter
HPK19_RS25620	COG4873	Protein conserved in bacteria
HPK19_RS25630	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HPK19_RS25635	COG3119	arylsulfatase activity
HPK19_RS25640	COG2197	response regulator
HPK19_RS25645	COG3852	Histidine kinase