locus-tag	class	description
AC20117_RS00015	COG0483	inositol monophosphate 1-phosphatase activity
AC20117_RS00020	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AC20117_RS00040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AC20117_RS00050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AC20117_RS00055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AC20117_RS00060	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AC20117_RS00080	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AC20117_RS00085	COG0739	heme binding
AC20117_RS00085	COG0741	lytic transglycosylase activity
AC20117_RS00085	COG1196	nuclear chromosome segregation
AC20117_RS00095	COG2884	Cell division ATP-binding protein ftsE
AC20117_RS00105	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AC20117_RS00175	COG0438	transferase activity, transferring glycosyl groups
AC20117_RS00200	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AC20117_RS00205	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AC20117_RS00230	COG2902	Dehydrogenase
AC20117_RS00265	COG0653	protein targeting
AC20117_RS00270	COG3214	Protein conserved in bacteria
AC20117_RS00275	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AC20117_RS00280	COG1040	competence protein
AC20117_RS00285	COG5401	PFAM Sporulation and spore germination
AC20117_RS00290	COG5000	phosphorelay sensor kinase activity
AC20117_RS00290	COG5002	protein histidine kinase activity
AC20117_RS00315	COG0714	Associated with various cellular activities
AC20117_RS00345	COG0482	sulfurtransferase activity
AC20117_RS00360	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AC20117_RS00370	COG0484	heat shock protein binding
AC20117_RS00375	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AC20117_RS00385	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AC20117_RS00390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC20117_RS00400	COG1842	Phage shock protein A
AC20117_RS00410	COG1615	UPF0182 protein
AC20117_RS00415	COG3480	Lon protease (S16) C-terminal proteolytic domain
AC20117_RS00470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AC20117_RS00475	COG2011	ABC-type metal ion transport system permease component
AC20117_RS00480	COG1464	Belongs to the NlpA lipoprotein family
AC20117_RS00490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AC20117_RS00495	COG0113	porphobilinogen synthase activity
AC20117_RS00505	COG0181	hydroxymethylbilane synthase activity
AC20117_RS00510	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AC20117_RS00515	COG3253	May function as heme-dependent peroxidase
AC20117_RS00520	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AC20117_RS00525	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AC20117_RS00530	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AC20117_RS00555	COG2154	pterin-4-alpha-carbinolamine dehydratase
AC20117_RS00560	COG2022	thiamine diphosphate biosynthetic process
AC20117_RS00570	COG2022	thiamine diphosphate biosynthetic process
AC20117_RS00570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC20117_RS00575	COG0352	thiamine-phosphate diphosphorylase activity
AC20117_RS00590	COG0513	Belongs to the DEAD box helicase family
AC20117_RS00605	COG0613	PHP domain protein
AC20117_RS00610	COG0006	proline dipeptidase activity
AC20117_RS00620	COG2239	Acts as a magnesium transporter
AC20117_RS00635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC20117_RS00645	COG1595	DNA-templated transcription, initiation
AC20117_RS00650	COG4122	O-methyltransferase activity
AC20117_RS00655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AC20117_RS00675	COG1611	Belongs to the LOG family
AC20117_RS00680	COG1126	abc transporter atp-binding protein
AC20117_RS00685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AC20117_RS00690	COG0765	amino acid transport
AC20117_RS00695	COG0765	amino acid transport
AC20117_RS00700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_RS00705	COG2171	N-acyltransferase activity
AC20117_RS00720	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AC20117_RS00755	COG1217	gtp-binding protein TYPA
AC20117_RS00760	COG4172	Belongs to the ABC transporter superfamily
AC20117_RS00765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AC20117_RS00770	COG0601	transmembrane transport
AC20117_RS00775	COG4166	transmembrane transport
AC20117_RS00820	COG0012	GTP binding
AC20117_RS00825	COG1322	Protein conserved in bacteria
AC20117_RS00830	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AC20117_RS00840	COG1570	exodeoxyribonuclease VII activity
AC20117_RS00845	COG1722	exodeoxyribonuclease VII activity
AC20117_RS00850	COG2326	polyphosphate kinase activity
AC20117_RS00855	COG0436	Aminotransferase
AC20117_RS00875	COG0517	IMP dehydrogenase activity
AC20117_RS00875	COG1125	glycine betaine transport
AC20117_RS00880	COG1051	belongs to the nudix hydrolase family
AC20117_RS00895	COG5002	protein histidine kinase activity
AC20117_RS00900	COG0745	RESPONSE REGULATOR receiver
AC20117_RS00920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AC20117_RS00925	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AC20117_RS00945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AC20117_RS00945	COG0519	Catalyzes the synthesis of GMP from XMP
AC20117_RS00960	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC20117_RS00960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AC20117_RS00965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AC20117_RS00970	COG0516	GMP reductase activity
AC20117_RS00990	COG0459	protein refolding
AC20117_RS00995	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AC20117_RS01000	COG4607	ABC-type enterochelin transport system periplasmic component
AC20117_RS01005	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AC20117_RS01010	COG4605	iron ion homeostasis
AC20117_RS01015	COG4604	ABC transporter, ATP-binding protein
AC20117_RS01025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC20117_RS01030	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AC20117_RS01070	COG1472	Belongs to the glycosyl hydrolase 3 family
AC20117_RS01075	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AC20117_RS01080	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AC20117_RS01110	COG0802	atpase or kinase
AC20117_RS01115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AC20117_RS01125	COG1486	melibiose metabolic process
AC20117_RS01130	COG2072	flavoprotein involved in K transport
AC20117_RS01155	COG2409	Drug exporters of the RND superfamily
AC20117_RS01175	COG0667	Aldo Keto reductase
AC20117_RS01225	COG1649	PFAM Uncharacterised BCR, COG1649
AC20117_RS01245	COG2132	Multicopper oxidase
AC20117_RS01255	COG0736	holo-[acyl-carrier-protein] synthase activity
AC20117_RS01265	COG1072	(Pantothenic acid kinase))
AC20117_RS01275	COG1970	mechanosensitive ion channel activity
AC20117_RS01285	COG1301	dicarboxylic acid transport
AC20117_RS01295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC20117_RS01300	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AC20117_RS01305	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AC20117_RS01315	COG0246	Mannitol dehydrogenase
AC20117_RS01320	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC20117_RS01320	COG2213	PTS system mannitol-specific
AC20117_RS01350	COG2894	cell division
AC20117_RS01380	COG0101	tRNA pseudouridine synthase activity
AC20117_RS01385	COG0203	ribosomal protein L17
AC20117_RS01390	COG0202	RNA polymerase activity
AC20117_RS01395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AC20117_RS01400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AC20117_RS01405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AC20117_RS01410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AC20117_RS01415	COG3191	aminopeptidase activity
AC20117_RS01430	COG2814	Major facilitator Superfamily
AC20117_RS01455	COG0563	adenylate kinase activity
AC20117_RS01465	COG0200	Binds to the 23S rRNA
AC20117_RS01470	COG1841	ribosomal large subunit assembly
AC20117_RS01475	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AC20117_RS01480	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AC20117_RS01485	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AC20117_RS01490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AC20117_RS01495	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AC20117_RS01500	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AC20117_RS01505	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AC20117_RS01510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AC20117_RS01515	COG0255	Belongs to the universal ribosomal protein uL29 family
AC20117_RS01520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AC20117_RS01525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AC20117_RS01530	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AC20117_RS01535	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AC20117_RS01540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AC20117_RS01545	COG0089	rRNA binding
AC20117_RS01550	COG0088	Forms part of the polypeptide exit tunnel
AC20117_RS01555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AC20117_RS01560	COG0051	transcription antitermination factor activity, RNA binding
AC20117_RS01565	COG2723	6-phospho-beta-galactosidase activity
AC20117_RS01580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AC20117_RS01585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AC20117_RS01590	COG0049	tRNA binding
AC20117_RS01595	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AC20117_RS01605	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AC20117_RS01605	COG2755	lipolytic protein G-D-S-L family
AC20117_RS01610	COG1414	Transcriptional regulator
AC20117_RS01615	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AC20117_RS01625	COG0183	Belongs to the thiolase family
AC20117_RS01630	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AC20117_RS01635	COG0596	Alpha beta hydrolase
AC20117_RS01645	COG3485	protocatechuate 3,4-dioxygenase
AC20117_RS01650	COG3485	protocatechuate 3,4-dioxygenase
AC20117_RS01665	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AC20117_RS01670	COG0085	RNA polymerase activity
AC20117_RS01675	COG0183	Belongs to the thiolase family
AC20117_RS01680	COG0442	prolyl-tRNA aminoacylation
AC20117_RS01685	COG0222	ribosome binding
AC20117_RS01690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AC20117_RS01705	COG0081	regulation of translation
AC20117_RS01710	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AC20117_RS01730	COG0436	Aminotransferase
AC20117_RS01735	COG2197	response regulator
AC20117_RS01755	COG1983	PspC domain protein
AC20117_RS01770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AC20117_RS01775	COG3485	protocatechuate 3,4-dioxygenase
AC20117_RS01785	COG0745	RESPONSE REGULATOR receiver
AC20117_RS01790	COG0456	acetyltransferase
AC20117_RS01795	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AC20117_RS01800	COG0494	nUDIX hydrolase
AC20117_RS01800	COG0406	alpha-ribazole phosphatase activity
AC20117_RS01805	COG1528	Iron-storage protein
AC20117_RS01810	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AC20117_RS01815	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AC20117_RS01825	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AC20117_RS01840	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AC20117_RS01850	COG2030	dehydratase
AC20117_RS01865	COG0693	protein deglycase activity
AC20117_RS01905	COG1132	(ABC) transporter
AC20117_RS01910	COG0438	transferase activity, transferring glycosyl groups
AC20117_RS01935	COG0446	pyridine nucleotide-disulphide oxidoreductase
AC20117_RS01935	COG1902	pentaerythritol trinitrate reductase activity
AC20117_RS01940	COG2258	MOSC domain
AC20117_RS01945	COG1115	amino acid carrier protein
AC20117_RS01965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC20117_RS01980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC20117_RS01995	COG1666	GTP binding
AC20117_RS02005	COG0501	Belongs to the peptidase M48B family
AC20117_RS02020	COG2267	carboxylic ester hydrolase activity
AC20117_RS02030	COG0753	catalase activity
AC20117_RS02120	COG1674	ftsk spoiiie
AC20117_RS02150	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_RS02160	COG0733	neurotransmitter:sodium symporter activity
AC20117_RS02175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_RS02190	COG2895	sulfate adenylyltransferase (ATP) activity
AC20117_RS02200	COG0175	sulfate reduction
AC20117_RS02205	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC20117_RS02235	COG0142	geranyltranstransferase activity
AC20117_RS02245	COG2226	methyltransferase
AC20117_RS02250	COG1169	isochorismate synthase
AC20117_RS02260	COG0765	amino acid transport
AC20117_RS02275	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AC20117_RS02285	COG4948	Mandelate Racemase Muconate Lactonizing
AC20117_RS02315	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC20117_RS02320	COG0022	dehydrogenase e1 component
AC20117_RS02335	COG1024	Enoyl-CoA hydratase
AC20117_RS02340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AC20117_RS02345	COG2151	metal-sulfur cluster biosynthetic enzyme
AC20117_RS02350	COG3396	Phenylacetate-CoA oxygenase
AC20117_RS02355	COG3460	Phenylacetate-CoA oxygenase
AC20117_RS02360	COG3396	Phenylacetate-CoA oxygenase
AC20117_RS02395	COG2030	dehydratase
AC20117_RS02395	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_RS02415	COG2755	lipolytic protein G-D-S-L family
AC20117_RS02420	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC20117_RS02425	COG1024	Enoyl-CoA hydratase
AC20117_RS02445	COG0488	(ABC) transporter
AC20117_RS02455	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AC20117_RS02485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AC20117_RS02495	COG0785	Cytochrome C biogenesis protein
AC20117_RS02500	COG3118	belongs to the thioredoxin family
AC20117_RS02505	COG0406	alpha-ribazole phosphatase activity
AC20117_RS02510	COG2353	YceI-like domain
AC20117_RS02520	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AC20117_RS02545	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AC20117_RS02550	COG2971	BadF BadG BcrA BcrD
AC20117_RS02560	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AC20117_RS02565	COG0640	Transcriptional regulator
AC20117_RS02570	COG0123	including yeast histone deacetylase and acetoin utilization protein
AC20117_RS02575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AC20117_RS02580	COG0569	domain protein
AC20117_RS02590	COG0248	Ppx GppA phosphatase
AC20117_RS02595	COG1754	DNA topoisomerase type I activity
AC20117_RS02595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AC20117_RS02605	COG2890	protein-(glutamine-N5) methyltransferase activity
AC20117_RS02615	COG1054	Belongs to the UPF0176 family
AC20117_RS02625	COG1111	helicase
AC20117_RS02625	COG1205	dead DEAH box helicase
AC20117_RS02675	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AC20117_RS02685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC20117_RS02725	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AC20117_RS02730	COG1408	metallophosphoesterase
AC20117_RS02750	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AC20117_RS02755	COG0151	Belongs to the GarS family
AC20117_RS02780	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AC20117_RS02800	COG0542	response to heat
AC20117_RS02815	COG2353	YceI-like domain
AC20117_RS02835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AC20117_RS02855	COG2003	Belongs to the UPF0758 family
AC20117_RS02860	COG0789	Transcriptional regulator
AC20117_RS02865	COG0484	heat shock protein binding
AC20117_RS02870	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AC20117_RS02875	COG0443	Heat shock 70 kDa protein
AC20117_RS02880	COG2409	Drug exporters of the RND superfamily
AC20117_RS02890	COG2226	methyltransferase
AC20117_RS02900	COG1280	lysine exporter protein (LysE YggA)
AC20117_RS02905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AC20117_RS02915	COG1309	transcriptional regulator
AC20117_RS02925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC20117_RS02940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AC20117_RS02955	COG4172	Belongs to the ABC transporter superfamily
AC20117_RS02960	COG4721	ABC-type cobalt transport system, permease component
AC20117_RS02970	COG1320	monovalent cation:proton antiporter activity
AC20117_RS02975	COG2212	antiporter activity
AC20117_RS02985	COG0651	ATP synthesis coupled electron transport
AC20117_RS02990	COG1006	Multisubunit Na H antiporter MnhC subunit
AC20117_RS02995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC20117_RS02995	COG2111	Na H antiporter
AC20117_RS03005	COG0717	Belongs to the dCTP deaminase family
AC20117_RS03010	COG1876	peptidase activity
AC20117_RS03015	COG3483	tryptophan 2,3-dioxygenase activity
AC20117_RS03025	COG0475	glutathione-regulated potassium exporter activity
AC20117_RS03065	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AC20117_RS03070	COG0679	Auxin Efflux Carrier
AC20117_RS03075	COG0433	COG0433 Predicted ATPase
AC20117_RS03090	COG3336	cytochrome c oxidase
AC20117_RS03095	COG0776	regulation of translation
AC20117_RS03100	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AC20117_RS03105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AC20117_RS03110	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AC20117_RS03140	COG1742	UPF0060 membrane protein
AC20117_RS03150	COG1120	ATPase activity
AC20117_RS03155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AC20117_RS03160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AC20117_RS03165	COG2267	carboxylic ester hydrolase activity
AC20117_RS03195	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AC20117_RS03200	COG0435	Glutathione S-transferase
AC20117_RS03205	COG2031	fatty acid transporter
AC20117_RS03210	COG2807	transmembrane transport
AC20117_RS03230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AC20117_RS03240	COG0519	Catalyzes the synthesis of GMP from XMP
AC20117_RS03245	COG0589	response to stress
AC20117_RS03255	COG0667	Aldo Keto reductase
AC20117_RS03260	COG0395	ABC-type sugar transport system, permease component
AC20117_RS03265	COG1175	transmembrane transport
AC20117_RS03285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AC20117_RS03300	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS03315	COG0509	glycine decarboxylation via glycine cleavage system
AC20117_RS03320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AC20117_RS03325	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC20117_RS03325	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC20117_RS03335	COG2807	transmembrane transport
AC20117_RS03355	COG2814	Major facilitator Superfamily
AC20117_RS03370	COG1609	Transcriptional regulator
AC20117_RS03390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_RS03415	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AC20117_RS03415	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AC20117_RS03420	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_RS03435	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AC20117_RS03435	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AC20117_RS03440	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AC20117_RS03445	COG0438	transferase activity, transferring glycosyl groups
AC20117_RS03455	COG0859	PFAM glycosyl transferase family 9
AC20117_RS03470	COG1191	sigma factor activity
AC20117_RS03495	COG1295	ribonuclease BN
AC20117_RS03510	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS03515	COG0436	Aminotransferase
AC20117_RS03525	COG0598	Magnesium transport protein CorA
AC20117_RS03550	COG0477	Major facilitator Superfamily
AC20117_RS03555	COG1473	amidohydrolase
AC20117_RS03570	COG3634	alkyl hydroperoxide reductase activity
AC20117_RS03575	COG1254	Belongs to the acylphosphatase family
AC20117_RS03585	COG1597	lipid kinase activity
AC20117_RS03590	COG1309	transcriptional regulator
AC20117_RS03600	COG0589	response to stress
AC20117_RS03620	COG3290	protein histidine kinase activity
AC20117_RS03625	COG4565	transcriptional regulatory protein
AC20117_RS03635	COG0412	Dienelactone hydrolase
AC20117_RS03640	COG0768	penicillin binding
AC20117_RS03665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AC20117_RS03670	COG0765	amino acid transport
AC20117_RS03675	COG1126	abc transporter atp-binding protein
AC20117_RS03690	COG3135	benzoate transporter
AC20117_RS03700	COG0655	NAD(P)H dehydrogenase (quinone) activity
AC20117_RS03710	COG1793	dna ligase
AC20117_RS03720	COG0667	Aldo Keto reductase
AC20117_RS03740	COG0583	DNA-binding transcription factor activity
AC20117_RS03745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC20117_RS03750	COG4948	Mandelate Racemase Muconate Lactonizing
AC20117_RS03755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC20117_RS03765	COG4608	Belongs to the ABC transporter superfamily
AC20117_RS03770	COG0444	Belongs to the ABC transporter superfamily
AC20117_RS03780	COG0601	transmembrane transport
AC20117_RS03785	COG0747	negative chemotaxis
AC20117_RS03790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC20117_RS03795	COG0589	response to stress
AC20117_RS03800	COG1414	Transcriptional regulator
AC20117_RS03805	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_RS03810	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AC20117_RS03830	COG4989	oxidoreductase activity
AC20117_RS03850	COG2124	cytochrome p450
AC20117_RS03860	COG1414	Transcriptional regulator
AC20117_RS03865	COG1301	dicarboxylic acid transport
AC20117_RS03880	COG1309	transcriptional regulator
AC20117_RS03885	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC20117_RS03885	COG1024	Enoyl-CoA hydratase
AC20117_RS03890	COG1960	acyl-CoA dehydrogenase activity
AC20117_RS03895	COG0318	PFAM AMP-dependent synthetase and ligase
AC20117_RS03910	COG0531	amino acid
AC20117_RS03925	COG0069	glutamate synthase activity
AC20117_RS03935	COG4335	DNA alkylation repair
AC20117_RS03970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AC20117_RS04015	COG1116	anion transmembrane transporter activity
AC20117_RS04030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC20117_RS04035	COG1228	amidohydrolase
AC20117_RS04045	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AC20117_RS04075	COG2217	Heavy metal translocating P-type atpase
AC20117_RS04080	COG2267	carboxylic ester hydrolase activity
AC20117_RS04085	COG1414	Transcriptional regulator
AC20117_RS04095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AC20117_RS04100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AC20117_RS04105	COG2610	gluconate transmembrane transporter activity
AC20117_RS04120	COG1940	carbohydrate kinase activity
AC20117_RS04130	COG0640	Transcriptional regulator
AC20117_RS04140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AC20117_RS04150	COG0640	Transcriptional regulator
AC20117_RS04165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AC20117_RS04170	COG1072	(Pantothenic acid kinase))
AC20117_RS04180	COG0747	negative chemotaxis
AC20117_RS04210	COG1295	ribonuclease BN
AC20117_RS04235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AC20117_RS04240	COG0247	lactate metabolic process
AC20117_RS04240	COG0277	FAD linked oxidase domain protein
AC20117_RS04250	COG0006	proline dipeptidase activity
AC20117_RS04260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_RS04265	COG0477	Major facilitator Superfamily
AC20117_RS04280	COG0686	Belongs to the AlaDH PNT family
AC20117_RS04305	COG0438	transferase activity, transferring glycosyl groups
AC20117_RS04310	COG0463	Glycosyl transferase, family 2
AC20117_RS04335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_RS04355	COG2197	response regulator
AC20117_RS04360	COG2814	Major facilitator Superfamily
AC20117_RS04370	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AC20117_RS04375	COG4638	Rieske (2fe-2S)
AC20117_RS04380	COG3135	benzoate transporter
AC20117_RS04385	COG1869	D-ribose catabolic process
AC20117_RS04390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC20117_RS04395	COG1879	ABC-type sugar transport system periplasmic component
AC20117_RS04400	COG1172	Belongs to the binding-protein-dependent transport system permease family
AC20117_RS04405	COG1129	ABC transporter
AC20117_RS04410	COG1609	Transcriptional regulator
AC20117_RS04420	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_RS04435	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AC20117_RS04445	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AC20117_RS04455	COG1063	alcohol dehydrogenase
AC20117_RS04460	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS04465	COG0800	Aldolase
AC20117_RS04485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC20117_RS04490	COG1090	epimerase
AC20117_RS04495	COG1595	DNA-templated transcription, initiation
AC20117_RS04500	COG0604	alcohol dehydrogenase
AC20117_RS04505	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AC20117_RS04505	COG1796	DNA polymerase
AC20117_RS04540	COG2197	response regulator
AC20117_RS04545	COG0443	Heat shock 70 kDa protein
AC20117_RS04570	COG2186	Transcriptional regulator
AC20117_RS04580	COG1027	Aspartate ammonia-lyase
AC20117_RS04600	COG0640	Transcriptional regulator
AC20117_RS04605	COG2814	Major facilitator Superfamily
AC20117_RS04610	COG0500	methyltransferase
AC20117_RS04615	COG2851	Citrate transporter
AC20117_RS04620	COG3290	protein histidine kinase activity
AC20117_RS04625	COG4565	transcriptional regulatory protein
AC20117_RS04635	COG3387	PFAM Glycoside hydrolase 15-related
AC20117_RS04655	COG0667	Aldo Keto reductase
AC20117_RS04660	COG0673	inositol 2-dehydrogenase activity
AC20117_RS04670	COG0517	IMP dehydrogenase activity
AC20117_RS04670	COG0617	tRNA 3'-terminal CCA addition
AC20117_RS04670	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AC20117_RS04675	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AC20117_RS04680	COG0022	dehydrogenase e1 component
AC20117_RS04685	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC20117_RS04700	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AC20117_RS04710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC20117_RS04720	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AC20117_RS04730	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS04750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC20117_RS04755	COG1937	Protein conserved in bacteria
AC20117_RS04765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AC20117_RS04775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC20117_RS04780	COG0477	Major facilitator Superfamily
AC20117_RS04815	COG1937	Protein conserved in bacteria
AC20117_RS04825	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_RS04835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC20117_RS04845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_RS04860	COG0583	DNA-binding transcription factor activity
AC20117_RS04865	COG1522	sequence-specific DNA binding
AC20117_RS04870	COG1280	lysine exporter protein (LysE YggA)
AC20117_RS04880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC20117_RS04895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC20117_RS04910	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC20117_RS04950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC20117_RS04970	COG3485	protocatechuate 3,4-dioxygenase
AC20117_RS04975	COG4638	Rieske (2fe-2S)
AC20117_RS04995	COG2197	response regulator
AC20117_RS05000	COG4829	muconolactone delta-isomerase
AC20117_RS05005	COG4948	Mandelate Racemase Muconate Lactonizing
AC20117_RS05010	COG0583	DNA-binding transcription factor activity
AC20117_RS05025	COG2050	protein possibly involved in aromatic compounds catabolism
AC20117_RS05030	COG0656	L-ascorbic acid biosynthetic process
AC20117_RS05060	COG1278	Cold shock
AC20117_RS05080	COG0154	amidase activity
AC20117_RS05105	COG1234	tRNA 3'-trailer cleavage
AC20117_RS05130	COG2267	carboxylic ester hydrolase activity
AC20117_RS05140	COG1597	lipid kinase activity
AC20117_RS05160	COG1690	Belongs to the RtcB family
AC20117_RS05200	COG2211	Major facilitator Superfamily
AC20117_RS05230	COG0656	L-ascorbic acid biosynthetic process
AC20117_RS05245	COG1960	acyl-CoA dehydrogenase activity
AC20117_RS05255	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS05265	COG1116	anion transmembrane transporter activity
AC20117_RS05270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_RS05275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_RS05280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC20117_RS05305	COG2197	response regulator
AC20117_RS05310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC20117_RS05325	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC20117_RS05330	COG0022	dehydrogenase e1 component
AC20117_RS05340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC20117_RS05345	COG1950	PFAM Membrane protein of
AC20117_RS05350	COG2223	nitrite transmembrane transporter activity
AC20117_RS05355	COG0243	molybdopterin cofactor binding
AC20117_RS05360	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC20117_RS05375	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AC20117_RS05395	COG1607	acyl-coa hydrolase
AC20117_RS05405	COG0436	Aminotransferase
AC20117_RS05420	COG1725	Transcriptional regulator
AC20117_RS05425	COG0589	response to stress
AC20117_RS05445	COG0583	DNA-binding transcription factor activity
AC20117_RS05450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC20117_RS05470	COG1864	DNA RNA non-specific endonuclease
AC20117_RS05470	COG3591	Belongs to the peptidase S1B family
AC20117_RS05490	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC20117_RS05505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AC20117_RS05510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AC20117_RS05515	COG0492	ferredoxin-NADP+ reductase activity
AC20117_RS05525	COG0477	Major facilitator Superfamily
AC20117_RS05530	COG1937	Protein conserved in bacteria
AC20117_RS05535	COG2217	Heavy metal translocating P-type atpase
AC20117_RS05555	COG2271	Major facilitator Superfamily
AC20117_RS05560	COG0697	spore germination
AC20117_RS05595	COG0534	Mate efflux family protein
AC20117_RS05605	COG1131	(ABC) transporter
AC20117_RS05625	COG2890	protein-(glutamine-N5) methyltransferase activity
AC20117_RS05645	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AC20117_RS05660	COG0833	amino acid
AC20117_RS05695	COG3177	Filamentation induced by cAMP protein fic
AC20117_RS05720	COG2814	Major facilitator Superfamily
AC20117_RS05750	COG0531	amino acid
AC20117_RS05775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC20117_RS05780	COG1929	Belongs to the glycerate kinase type-1 family
AC20117_RS05785	COG3960	tartronate-semialdehyde synthase activity
AC20117_RS05790	COG2084	Dehydrogenase
AC20117_RS05795	COG3622	Belongs to the hyi family
AC20117_RS05805	COG3655	Transcriptional regulator
AC20117_RS05810	COG3257	ureidoglycine aminohydrolase activity
AC20117_RS05820	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AC20117_RS05830	COG1414	Transcriptional regulator
AC20117_RS05835	COG0590	tRNA wobble adenosine to inosine editing
AC20117_RS05845	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AC20117_RS05845	COG3608	succinylglutamate desuccinylase aspartoacylase
AC20117_RS05855	COG2080	2 iron, 2 sulfur cluster binding
AC20117_RS05855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC20117_RS05865	COG0583	DNA-binding transcription factor activity
AC20117_RS05870	COG1053	succinate dehydrogenase
AC20117_RS05905	COG0405	Gamma-glutamyltransferase
AC20117_RS05970	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AC20117_RS05980	COG0469	pyruvate kinase activity
AC20117_RS05995	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AC20117_RS06030	COG3583	domain protein
AC20117_RS06035	COG1045	serine acetyltransferase
AC20117_RS06050	COG1253	flavin adenine dinucleotide binding
AC20117_RS06080	COG2188	Transcriptional regulator
AC20117_RS06095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC20117_RS06105	COG2814	Major facilitator Superfamily
AC20117_RS06110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC20117_RS06140	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC20117_RS06175	COG1280	lysine exporter protein (LysE YggA)
AC20117_RS06180	COG2409	Drug exporters of the RND superfamily
AC20117_RS06185	COG2084	Dehydrogenase
AC20117_RS06230	COG0384	phenazine biosynthesis protein PhzF
AC20117_RS06240	COG0359	binds to the 23S rRNA
AC20117_RS06245	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AC20117_RS06255	COG0360	Binds together with S18 to 16S ribosomal RNA
AC20117_RS06265	COG2197	response regulator
AC20117_RS06270	COG4585	Histidine kinase
AC20117_RS06285	COG0738	Major facilitator superfamily
AC20117_RS06290	COG0488	(ABC) transporter
AC20117_RS06300	COG2197	response regulator
AC20117_RS06305	COG0179	Fumarylacetoacetate (FAA) hydrolase
AC20117_RS06320	COG2197	response regulator
AC20117_RS06335	COG1136	(ABC) transporter
AC20117_RS06335	COG0577	efflux transmembrane transporter activity
AC20117_RS06340	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AC20117_RS06355	COG1083	cytidylyl-transferase
AC20117_RS06360	COG2089	acid synthase
AC20117_RS06365	COG0463	Glycosyl transferase, family 2
AC20117_RS06435	COG1063	alcohol dehydrogenase
AC20117_RS06465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AC20117_RS06475	COG0747	negative chemotaxis
AC20117_RS06480	COG0601	transmembrane transport
AC20117_RS06485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AC20117_RS06490	COG4172	Belongs to the ABC transporter superfamily
AC20117_RS06505	COG0477	Major facilitator Superfamily
AC20117_RS06510	COG1234	tRNA 3'-trailer cleavage
AC20117_RS06515	COG0583	DNA-binding transcription factor activity
AC20117_RS06525	COG4770	biotin carboxylase activity
AC20117_RS06530	COG1984	allophanate hydrolase subunit 2
AC20117_RS06535	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AC20117_RS06540	COG1914	H( )-stimulated, divalent metal cation uptake system
AC20117_RS06545	COG4336	lyase activity
AC20117_RS06585	COG0583	DNA-binding transcription factor activity
AC20117_RS06595	COG1063	alcohol dehydrogenase
AC20117_RS06600	COG1053	succinate dehydrogenase
AC20117_RS06605	COG0477	Major facilitator Superfamily
AC20117_RS06630	COG1053	succinate dehydrogenase
AC20117_RS06635	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AC20117_RS06640	COG4974	Belongs to the 'phage' integrase family
AC20117_RS06655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AC20117_RS06675	COG0765	amino acid transport
AC20117_RS06680	COG0765	amino acid transport
AC20117_RS06695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AC20117_RS06700	COG0277	FAD linked oxidase domain protein
AC20117_RS06700	COG0247	lactate metabolic process
AC20117_RS06730	COG0402	S-adenosylhomocysteine deaminase activity
AC20117_RS06775	COG1335	isochorismatase
AC20117_RS06795	COG4608	Belongs to the ABC transporter superfamily
AC20117_RS06800	COG0444	Belongs to the ABC transporter superfamily
AC20117_RS06805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AC20117_RS06810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AC20117_RS06820	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC20117_RS06865	COG0758	DNA mediated transformation
AC20117_RS06875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC20117_RS06880	COG1024	Enoyl-CoA hydratase
AC20117_RS06885	COG0318	PFAM AMP-dependent synthetase and ligase
AC20117_RS06900	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS06905	COG1960	acyl-CoA dehydrogenase activity
AC20117_RS06910	COG0183	Belongs to the thiolase family
AC20117_RS06915	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC20117_RS06945	COG0410	ABC transporter
AC20117_RS06950	COG2050	protein possibly involved in aromatic compounds catabolism
AC20117_RS06955	COG1846	Transcriptional regulator
AC20117_RS07010	COG3328	transposase activity
AC20117_RS07055	COG2814	Major facilitator Superfamily
AC20117_RS07060	COG0640	Transcriptional regulator
AC20117_RS07075	COG0803	Belongs to the bacterial solute-binding protein 9 family
AC20117_RS07105	COG0659	secondary active sulfate transmembrane transporter activity
AC20117_RS07135	COG1140	nitrate reductase beta subunit
AC20117_RS07200	COG2132	Multicopper oxidase
AC20117_RS07215	COG0583	DNA-binding transcription factor activity
AC20117_RS07240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_RS07255	COG4638	Rieske (2fe-2S)
AC20117_RS07270	COG0588	phosphoglycerate mutase activity
AC20117_RS07275	COG0617	tRNA 3'-terminal CCA addition
AC20117_RS07295	COG0492	ferredoxin-NADP+ reductase activity
AC20117_RS07300	COG3118	belongs to the thioredoxin family
AC20117_RS07305	COG3409	Peptidoglycan-binding domain 1 protein
AC20117_RS07305	COG0860	N-Acetylmuramoyl-L-alanine amidase
AC20117_RS07315	COG1475	DNA binding
AC20117_RS07320	COG1192	Involved in chromosome partitioning
AC20117_RS07325	COG0357	Ribosomal RNA small subunit methyltransferase G
AC20117_RS07335	COG0706	membrane insertase activity
AC20117_RS07340	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AC20117_RS07345	COG0594	ribonuclease P activity
AC20117_RS07350	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AC20117_RS07355	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AC20117_RS07360	COG0592	DNA-directed DNA polymerase activity
AC20117_RS07365	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AC20117_RS07370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AC20117_RS07375	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AC20117_RS07380	COG0187	DNA topoisomerase II activity
AC20117_RS07385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AC20117_RS07390	COG3266	domain, Protein
AC20117_RS07410	COG1215	transferase activity, transferring glycosyl groups
AC20117_RS07425	COG0705	Rhomboid family
AC20117_RS07425	COG0457	Tetratricopeptide repeat
AC20117_RS07430	COG0281	malic enzyme
AC20117_RS07440	COG3764	Sortase (surface protein transpeptidase)
AC20117_RS07450	COG0515	serine threonine protein kinase
AC20117_RS07450	COG2815	serine threonine protein kinase
AC20117_RS07455	COG0515	serine threonine protein kinase
AC20117_RS07475	COG1716	ATPase activity
AC20117_RS07480	COG1716	ATPase activity
AC20117_RS07490	COG0346	lactoylglutathione lyase activity
AC20117_RS07505	COG0483	inositol monophosphate 1-phosphatase activity
AC20117_RS07510	COG1024	Enoyl-CoA hydratase
AC20117_RS07515	COG2353	YceI-like domain
AC20117_RS07555	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AC20117_RS07565	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AC20117_RS07570	COG1609	Transcriptional regulator
AC20117_RS07585	COG0561	phosphatase activity
AC20117_RS07590	COG0584	glycerophosphoryl diester phosphodiesterase
AC20117_RS07595	COG1929	Belongs to the glycerate kinase type-1 family
AC20117_RS07615	COG3360	Dodecin
AC20117_RS07620	COG2233	PERMEase
AC20117_RS07625	COG0778	Nitroreductase
AC20117_RS07630	COG0033	Phosphoglucomutase
AC20117_RS07645	COG0798	PFAM Bile acid sodium symporter
AC20117_RS07650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AC20117_RS07660	COG2249	NAD(P)H dehydrogenase (quinone) activity
AC20117_RS07665	COG1733	regulation of RNA biosynthetic process
AC20117_RS07670	COG3104	oligopeptide transport
AC20117_RS07680	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AC20117_RS07685	COG3340	Belongs to the peptidase S51 family
AC20117_RS07690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AC20117_RS07705	COG1597	lipid kinase activity
AC20117_RS07710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AC20117_RS07715	COG0561	phosphatase activity
AC20117_RS07725	COG3654	unkown
AC20117_RS07745	COG2027	D-alanyl-D-alanine carboxypeptidase
AC20117_RS07755	COG0037	tRNA processing
AC20117_RS07765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AC20117_RS07770	COG0302	gtp cyclohydrolase
AC20117_RS07780	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AC20117_RS07785	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AC20117_RS07810	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AC20117_RS07815	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AC20117_RS07835	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AC20117_RS07845	COG3237	CsbD-like
AC20117_RS07865	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AC20117_RS07895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AC20117_RS07920	COG0456	acetyltransferase
AC20117_RS07925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AC20117_RS07930	COG1917	Cupin 2, conserved barrel domain protein
AC20117_RS07935	COG5285	phytanoyl-CoA dioxygenase
AC20117_RS07945	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_RS07950	COG0831	urea catabolic process
AC20117_RS07955	COG0832	Belongs to the urease beta subunit family
AC20117_RS07960	COG0804	urea catabolic process
AC20117_RS07965	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AC20117_RS07970	COG0830	nickel cation binding
AC20117_RS07975	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AC20117_RS07980	COG0829	nickel cation binding
AC20117_RS07985	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AC20117_RS07990	COG0531	amino acid
AC20117_RS08015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AC20117_RS08020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC20117_RS08020	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AC20117_RS08020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AC20117_RS08030	COG1349	DNA-binding transcription factor activity
AC20117_RS08055	COG2733	membrane
AC20117_RS08060	COG0584	glycerophosphoryl diester phosphodiesterase
AC20117_RS08065	COG3387	PFAM Glycoside hydrolase 15-related
AC20117_RS08085	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AC20117_RS08105	COG2252	PERMEase
AC20117_RS08110	COG2372	response to copper ion
AC20117_RS08185	COG1653	transport
AC20117_RS08190	COG1175	transmembrane transport
AC20117_RS08195	COG0395	ABC-type sugar transport system, permease component
AC20117_RS08200	COG1609	Transcriptional regulator
AC20117_RS08210	COG4941	Belongs to the sigma-70 factor family
AC20117_RS08225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AC20117_RS08255	COG1172	Belongs to the binding-protein-dependent transport system permease family
AC20117_RS08260	COG1129	ABC transporter
AC20117_RS08265	COG1940	carbohydrate kinase activity
AC20117_RS08270	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AC20117_RS08310	COG1435	thymidine kinase activity
AC20117_RS08320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AC20117_RS08330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC20117_RS08350	COG1832	CoA-binding protein
AC20117_RS08370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC20117_RS08375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_RS08385	COG1116	anion transmembrane transporter activity
AC20117_RS08395	COG1832	CoA-binding protein
AC20117_RS08405	COG0477	Major facilitator Superfamily
AC20117_RS08430	COG2315	Protein conserved in bacteria
AC20117_RS08455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AC20117_RS08460	COG0047	phosphoribosylformylglycinamidine synthase activity
AC20117_RS08465	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AC20117_RS08485	COG1846	Transcriptional regulator
AC20117_RS08505	COG1126	abc transporter atp-binding protein
AC20117_RS08510	COG0765	amino acid transport
AC20117_RS08515	COG0765	amino acid transport
AC20117_RS08530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AC20117_RS08610	COG2814	Major facilitator Superfamily
AC20117_RS08640	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AC20117_RS08660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC20117_RS08665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AC20117_RS08670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AC20117_RS08685	COG2855	membrane
AC20117_RS08695	COG3634	alkyl hydroperoxide reductase activity
AC20117_RS08700	COG4106	trans-aconitate 2-methyltransferase activity
AC20117_RS08720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC20117_RS08725	COG0251	oxidation-reduction process
AC20117_RS08760	COG1414	Transcriptional regulator
AC20117_RS08770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC20117_RS08790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_RS08795	COG0523	cobalamin synthesis protein
AC20117_RS08815	COG3949	Membrane
AC20117_RS08865	COG0252	asparaginase activity
AC20117_RS08870	COG2807	transmembrane transport
AC20117_RS08875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_RS08885	COG1953	Uracil, thiamine, allantoin
AC20117_RS08890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC20117_RS08905	COG1609	Transcriptional regulator
AC20117_RS08920	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AC20117_RS08930	COG1473	amidohydrolase
AC20117_RS08980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_RS09005	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_RS09010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC20117_RS09025	COG1174	glycine betaine transport
AC20117_RS09035	COG1174	glycine betaine transport
AC20117_RS09040	COG1732	Glycine betaine
AC20117_RS09045	COG3119	arylsulfatase activity
AC20117_RS09050	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AC20117_RS09075	COG0640	Transcriptional regulator
AC20117_RS09085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC20117_RS09100	COG0477	Major facilitator Superfamily
AC20117_RS09135	COG2910	NAD(P)H-binding
AC20117_RS09140	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AC20117_RS09150	COG2807	transmembrane transport
AC20117_RS09170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC20117_RS09180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AC20117_RS09190	COG1129	ABC transporter
AC20117_RS09195	COG1172	Belongs to the binding-protein-dependent transport system permease family
AC20117_RS09215	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AC20117_RS09225	COG1414	Transcriptional regulator
AC20117_RS09240	COG1609	Transcriptional regulator
AC20117_RS09250	COG0477	Major facilitator Superfamily
AC20117_RS09260	COG0698	ribose 5-phosphate isomerase
AC20117_RS09265	COG2376	Dihydroxyacetone kinase
AC20117_RS09270	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS09275	COG1082	Xylose isomerase domain protein TIM barrel
AC20117_RS09285	COG3959	Transketolase, thiamine diphosphate binding domain
AC20117_RS09290	COG3958	Transketolase
AC20117_RS09315	COG1414	Transcriptional regulator
AC20117_RS09345	COG2124	cytochrome p450
AC20117_RS09350	COG0028	Belongs to the TPP enzyme family
AC20117_RS09375	COG4176	ABC-type proline glycine betaine transport system permease component
AC20117_RS09385	COG1116	anion transmembrane transporter activity
AC20117_RS09385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC20117_RS09395	COG0667	Aldo Keto reductase
AC20117_RS09415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_RS09435	COG2271	Major facilitator Superfamily
AC20117_RS09450	COG1929	Belongs to the glycerate kinase type-1 family
AC20117_RS09455	COG3246	L-lysine catabolic process to acetate
AC20117_RS09470	COG1609	Transcriptional regulator
AC20117_RS09480	COG3314	Sporulation integral membrane protein YlbJ
AC20117_RS09485	COG2135	peptidase activity
AC20117_RS09495	COG3634	alkyl hydroperoxide reductase activity
AC20117_RS09515	COG1063	alcohol dehydrogenase
AC20117_RS09520	COG2860	membrane
AC20117_RS09535	COG0366	Alpha amylase catalytic
AC20117_RS09545	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AC20117_RS09550	COG1113	amino acid transport
AC20117_RS09570	COG2130	NADP-dependent
AC20117_RS09580	COG0277	FAD linked oxidase domain protein
AC20117_RS09600	COG1595	DNA-templated transcription, initiation
AC20117_RS09610	COG0583	DNA-binding transcription factor activity
AC20117_RS09630	COG1414	Transcriptional regulator
AC20117_RS09640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AC20117_RS09645	COG1024	Enoyl-CoA hydratase
AC20117_RS09655	COG1942	4-Oxalocrotonate Tautomerase
AC20117_RS09660	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_RS09665	COG0596	Alpha beta hydrolase
AC20117_RS09680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_RS09685	COG1802	Transcriptional regulator
AC20117_RS09690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC20117_RS09695	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC20117_RS09700	COG0542	response to heat
AC20117_RS09720	COG0596	Alpha beta hydrolase
AC20117_RS09730	COG2132	Multicopper oxidase
AC20117_RS09755	COG1793	dna ligase
AC20117_RS09760	COG2197	response regulator
AC20117_RS09765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC20117_RS09775	COG0589	response to stress
AC20117_RS09795	COG0583	DNA-binding transcription factor activity
AC20117_RS09805	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AC20117_RS09820	COG0351	phosphomethylpyrimidine kinase
AC20117_RS09850	COG0343	queuine tRNA-ribosyltransferase activity
AC20117_RS09880	COG3842	ATPase activity
AC20117_RS09905	COG1960	acyl-CoA dehydrogenase activity
AC20117_RS09920	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AC20117_RS09930	COG1414	Transcriptional regulator
AC20117_RS09940	COG0574	Belongs to the PEP-utilizing enzyme family
AC20117_RS09940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AC20117_RS09945	COG3848	Pyruvate phosphate dikinase
AC20117_RS09945	COG0574	Belongs to the PEP-utilizing enzyme family
AC20117_RS09950	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS09975	COG0477	Major facilitator Superfamily
AC20117_RS09980	COG1234	tRNA 3'-trailer cleavage
AC20117_RS09995	COG4115	mRNA cleavage
AC20117_RS10030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC20117_RS10035	COG3546	catalase activity
AC20117_RS10040	COG0564	pseudouridine synthase activity
AC20117_RS10055	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AC20117_RS10060	COG1201	RNA secondary structure unwinding
AC20117_RS10080	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AC20117_RS10125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AC20117_RS10135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC20117_RS10140	COG2062	phosphohistidine phosphatase, SixA
AC20117_RS10160	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AC20117_RS10165	COG3848	Pyruvate phosphate dikinase
AC20117_RS10165	COG0574	Belongs to the PEP-utilizing enzyme family
AC20117_RS10175	COG1959	2 iron, 2 sulfur cluster binding
AC20117_RS10185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC20117_RS10190	COG0514	ATP-dependent DNA helicase (RecQ)
AC20117_RS10200	COG1505	serine-type exopeptidase activity
AC20117_RS10210	COG4085	toxin activity
AC20117_RS10210	COG0737	Belongs to the 5'-nucleotidase family
AC20117_RS10210	COG1525	nuclease
AC20117_RS10225	COG1966	Carbon starvation protein
AC20117_RS10260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AC20117_RS10265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AC20117_RS10285	COG0588	phosphoglycerate mutase activity
AC20117_RS10295	COG5002	protein histidine kinase activity
AC20117_RS10320	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AC20117_RS10325	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AC20117_RS10330	COG0215	cysteine-tRNA ligase activity
AC20117_RS10335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC20117_RS10360	COG1295	ribonuclease BN
AC20117_RS10385	COG0366	Alpha amylase catalytic
AC20117_RS10390	COG0366	Alpha amylase catalytic
AC20117_RS10395	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AC20117_RS10465	COG0277	FAD linked oxidase domain protein
AC20117_RS10470	COG2264	protein methyltransferase activity
AC20117_RS10480	COG3842	ATPase activity
AC20117_RS10520	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AC20117_RS10565	COG0582	viral genome integration into host DNA
AC20117_RS10595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC20117_RS10600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_RS10605	COG0477	Major facilitator Superfamily
AC20117_RS10610	COG1609	Transcriptional regulator
AC20117_RS10615	COG0673	inositol 2-dehydrogenase activity
AC20117_RS10625	COG1053	succinate dehydrogenase
AC20117_RS10630	COG1414	Transcriptional regulator
AC20117_RS10640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AC20117_RS10645	COG0477	Major facilitator Superfamily
AC20117_RS10675	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AC20117_RS10695	COG2314	TM2 domain
AC20117_RS10700	COG0459	protein refolding
AC20117_RS10710	COG0328	RNA-DNA hybrid ribonuclease activity
AC20117_RS10720	COG2205	protein histidine kinase activity
AC20117_RS10725	COG0745	RESPONSE REGULATOR receiver
AC20117_RS10735	COG1061	Type III restriction enzyme res subunit
AC20117_RS10750	COG1278	Cold shock
AC20117_RS10760	COG2814	Major facilitator Superfamily
AC20117_RS10775	COG0739	heme binding
AC20117_RS10810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AC20117_RS10830	COG1132	(ABC) transporter
AC20117_RS10855	COG0668	transmembrane transport
AC20117_RS10860	COG0045	succinate-CoA ligase (ADP-forming) activity
AC20117_RS10870	COG1063	alcohol dehydrogenase
AC20117_RS10875	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AC20117_RS10890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC20117_RS10900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC20117_RS10915	COG1414	Transcriptional regulator
AC20117_RS10950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AC20117_RS10975	COG1760	l-serine dehydratase
AC20117_RS11030	COG0028	Belongs to the TPP enzyme family
AC20117_RS11040	COG2186	Transcriptional regulator
AC20117_RS11045	COG1653	transport
AC20117_RS11050	COG1175	transmembrane transport
AC20117_RS11055	COG0395	ABC-type sugar transport system, permease component
AC20117_RS11060	COG4948	Mandelate Racemase Muconate Lactonizing
AC20117_RS11065	COG0800	Aldolase
AC20117_RS11070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC20117_RS11080	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AC20117_RS11085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AC20117_RS11090	COG1063	alcohol dehydrogenase
AC20117_RS11100	COG0739	heme binding
AC20117_RS11110	COG0431	NADPH-dependent FMN reductase
AC20117_RS11140	COG0477	Major facilitator Superfamily
AC20117_RS11155	COG1473	amidohydrolase
AC20117_RS11160	COG3012	SEC-C Motif Domain Protein
AC20117_RS11165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AC20117_RS11170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AC20117_RS11190	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AC20117_RS11195	COG0076	glutamate decarboxylase activity
AC20117_RS11210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC20117_RS11260	COG1329	Transcriptional regulator
AC20117_RS11265	COG1309	transcriptional regulator
AC20117_RS11280	COG1278	Cold shock
AC20117_RS11340	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS11345	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AC20117_RS11380	COG0671	phosphoesterase, PA-phosphatase related
AC20117_RS11400	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AC20117_RS11405	COG0831	urea catabolic process
AC20117_RS11410	COG0832	Belongs to the urease beta subunit family
AC20117_RS11415	COG0804	urea catabolic process
AC20117_RS11420	COG0830	nickel cation binding
AC20117_RS11425	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AC20117_RS11430	COG0829	nickel cation binding
AC20117_RS11445	COG2323	membrane
AC20117_RS11455	COG2197	response regulator
AC20117_RS11460	COG4585	Histidine kinase
AC20117_RS11470	COG0252	asparaginase activity
AC20117_RS11490	COG0484	heat shock protein binding
AC20117_RS11500	COG0789	Transcriptional regulator
AC20117_RS11540	COG2814	Major facilitator Superfamily
AC20117_RS11545	COG0791	NLP P60 protein
AC20117_RS11545	COG1388	LysM domain
AC20117_RS11555	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AC20117_RS11565	COG0156	8-amino-7-oxononanoate synthase activity
AC20117_RS11570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AC20117_RS11575	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AC20117_RS11580	COG2188	Transcriptional regulator
AC20117_RS11585	COG1620	l-lactate permease
AC20117_RS11595	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AC20117_RS11595	COG2066	Belongs to the glutaminase family
AC20117_RS11600	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC20117_RS11615	COG0697	spore germination
AC20117_RS11620	COG1090	epimerase
AC20117_RS11625	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AC20117_RS11655	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AC20117_RS11660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AC20117_RS11665	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AC20117_RS11670	COG1120	ATPase activity
AC20117_RS11680	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AC20117_RS11680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC20117_RS11705	COG1902	pentaerythritol trinitrate reductase activity
AC20117_RS11740	COG0477	Major facilitator Superfamily
AC20117_RS11770	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AC20117_RS11775	COG0702	epimerase
AC20117_RS11785	COG0783	Belongs to the Dps family
AC20117_RS11805	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AC20117_RS11805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC20117_RS11815	COG2329	Antibiotic biosynthesis monooxygenase
AC20117_RS11825	COG3639	organic phosphonate transmembrane transporter activity
AC20117_RS11830	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AC20117_RS11850	COG0647	UMP catabolic process
AC20117_RS11855	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AC20117_RS11865	COG0789	Transcriptional regulator
AC20117_RS11870	COG1064	alcohol dehydrogenase
AC20117_RS11925	COG0179	Fumarylacetoacetate (FAA) hydrolase
AC20117_RS11930	COG1802	Transcriptional regulator
AC20117_RS11935	COG1953	Uracil, thiamine, allantoin
AC20117_RS11945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC20117_RS11955	COG0477	Major facilitator Superfamily
AC20117_RS11970	COG1802	Transcriptional regulator
AC20117_RS11990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC20117_RS11995	COG2072	flavoprotein involved in K transport
AC20117_RS12005	COG0657	acetylesterase activity
AC20117_RS12010	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS12015	COG1053	succinate dehydrogenase
AC20117_RS12025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC20117_RS12060	COG0477	Major facilitator Superfamily
AC20117_RS12065	COG0028	Belongs to the TPP enzyme family
AC20117_RS12070	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AC20117_RS12075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_RS12085	COG2186	Transcriptional regulator
AC20117_RS12090	COG0747	negative chemotaxis
AC20117_RS12100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AC20117_RS12120	COG2186	Transcriptional regulator
AC20117_RS12125	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS12130	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_RS12140	COG0473	3-isopropylmalate dehydrogenase activity
AC20117_RS12145	COG0583	DNA-binding transcription factor activity
AC20117_RS12155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_RS12170	COG0436	Aminotransferase
AC20117_RS12175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC20117_RS12180	COG2364	Membrane
AC20117_RS12200	COG1960	acyl-CoA dehydrogenase activity
AC20117_RS12205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AC20117_RS12215	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS12225	COG0579	oxidoreductase
AC20117_RS12245	COG2358	TRAP transporter, solute receptor (TAXI family
AC20117_RS12255	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS12265	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC20117_RS12270	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_RS12275	COG1960	acyl-CoA dehydrogenase activity
AC20117_RS12295	COG0531	amino acid
AC20117_RS12305	COG0833	amino acid
AC20117_RS12310	COG2124	cytochrome p450
AC20117_RS12335	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AC20117_RS12340	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AC20117_RS12355	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_RS12375	COG2508	Transcriptional regulator
AC20117_RS12415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_RS12420	COG0778	Nitroreductase
AC20117_RS12420	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AC20117_RS12425	COG1120	ATPase activity
AC20117_RS12430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AC20117_RS12445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC20117_RS12515	COG1917	Cupin 2, conserved barrel domain protein
AC20117_RS12515	COG4977	sequence-specific DNA binding
AC20117_RS12520	COG0583	DNA-binding transcription factor activity
AC20117_RS12525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC20117_RS12535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_RS12545	COG1234	tRNA 3'-trailer cleavage
AC20117_RS12550	COG1454	alcohol dehydrogenase
AC20117_RS12555	COG1802	Transcriptional regulator
AC20117_RS12560	COG1053	succinate dehydrogenase
AC20117_RS12580	COG2205	protein histidine kinase activity
AC20117_RS12585	COG0745	RESPONSE REGULATOR receiver
AC20117_RS12590	COG0574	Belongs to the PEP-utilizing enzyme family
AC20117_RS12590	COG3848	Pyruvate phosphate dikinase
AC20117_RS12595	COG0517	IMP dehydrogenase activity
AC20117_RS12595	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AC20117_RS12685	COG1595	DNA-templated transcription, initiation
AC20117_RS12695	COG0028	Belongs to the TPP enzyme family
AC20117_RS12700	COG1802	Transcriptional regulator
AC20117_RS12715	COG3608	succinylglutamate desuccinylase aspartoacylase
AC20117_RS12725	COG0765	amino acid transport
AC20117_RS12785	COG0640	Transcriptional regulator
AC20117_RS12800	COG1595	DNA-templated transcription, initiation
AC20117_RS12840	COG0488	(ABC) transporter
AC20117_RS12865	COG1522	sequence-specific DNA binding
AC20117_RS12875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AC20117_RS12885	COG2186	Transcriptional regulator
AC20117_RS12890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC20117_RS12895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_RS12915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC20117_RS12930	COG3485	protocatechuate 3,4-dioxygenase
AC20117_RS12950	COG0028	Belongs to the TPP enzyme family
AC20117_RS12985	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AC20117_RS12985	COG2066	Belongs to the glutaminase family
AC20117_RS13045	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AC20117_RS13065	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AC20117_RS13065	COG5479	isomerase activity
AC20117_RS13095	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AC20117_RS13115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AC20117_RS13125	COG2957	Belongs to the agmatine deiminase family
AC20117_RS13130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC20117_RS13140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC20117_RS13155	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AC20117_RS13170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AC20117_RS13185	COG3842	ATPase activity
AC20117_RS13190	COG1176	ABC-type spermidine putrescine transport system, permease component I
AC20117_RS13195	COG1177	transmembrane transport
AC20117_RS13220	COG5416	Lipopolysaccharide assembly protein A domain
AC20117_RS13230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AC20117_RS13240	COG3173	Aminoglycoside phosphotransferase
AC20117_RS13275	COG0406	alpha-ribazole phosphatase activity
AC20117_RS13290	COG0753	catalase activity
AC20117_RS13305	COG0589	response to stress
AC20117_RS13330	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AC20117_RS13350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AC20117_RS13360	COG0747	negative chemotaxis
AC20117_RS13365	COG3971	2-oxopent-4-enoate hydratase activity
AC20117_RS13375	COG0438	transferase activity, transferring glycosyl groups
AC20117_RS13375	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AC20117_RS13425	COG0477	Major facilitator Superfamily
AC20117_RS13430	COG0138	bifunctional purine biosynthesis protein purh
AC20117_RS13440	COG2838	Isocitrate dehydrogenase
AC20117_RS13470	COG0385	Bile acid
AC20117_RS13475	COG0673	inositol 2-dehydrogenase activity
AC20117_RS13485	COG1136	(ABC) transporter
AC20117_RS13490	COG0577	efflux transmembrane transporter activity
AC20117_RS13490	COG1136	(ABC) transporter
AC20117_RS13500	COG0395	ABC-type sugar transport system, permease component
AC20117_RS13505	COG1175	transmembrane transport
AC20117_RS13510	COG1653	transport
AC20117_RS13525	COG2226	methyltransferase
AC20117_RS13535	COG0492	ferredoxin-NADP+ reductase activity
AC20117_RS13540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AC20117_RS13545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AC20117_RS13550	COG4585	Histidine kinase
AC20117_RS13555	COG2197	response regulator
AC20117_RS13565	COG0477	Major facilitator Superfamily
AC20117_RS13590	COG0583	DNA-binding transcription factor activity
AC20117_RS13625	COG0180	Tryptophanyl-tRNA synthetase
AC20117_RS13645	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AC20117_RS13660	COG2009	succinate dehydrogenase
AC20117_RS13670	COG1473	amidohydrolase
AC20117_RS13670	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AC20117_RS13675	COG1744	ABC transporter substrate-binding protein PnrA-like
AC20117_RS13680	COG3845	ABC transporter
AC20117_RS13685	COG4603	Belongs to the binding-protein-dependent transport system permease family
AC20117_RS13690	COG1079	Belongs to the binding-protein-dependent transport system permease family
AC20117_RS13705	COG0586	Pfam SNARE associated Golgi protein
AC20117_RS13710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AC20117_RS13715	COG3956	TIGRFAM MazG family protein
AC20117_RS13720	COG0148	phosphopyruvate hydratase activity
AC20117_RS13745	COG1252	NADH dehydrogenase
AC20117_RS13790	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AC20117_RS13800	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AC20117_RS13810	COG2017	converts alpha-aldose to the beta-anomer
AC20117_RS13820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AC20117_RS13830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC20117_RS13840	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AC20117_RS13850	COG1331	Highly conserved protein containing a thioredoxin domain
AC20117_RS13860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AC20117_RS13865	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AC20117_RS13880	COG2197	response regulator
AC20117_RS13915	COG0114	fumarate hydratase activity
AC20117_RS13920	COG0288	reversible hydration of carbon dioxide
AC20117_RS13930	COG1494	fructose-1,6-bisphosphatase
AC20117_RS13940	COG1482	cell wall glycoprotein biosynthetic process
AC20117_RS13955	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AC20117_RS14000	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AC20117_RS14005	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AC20117_RS14025	COG1022	Amp-dependent synthetase and ligase
AC20117_RS14055	COG0714	Associated with various cellular activities
AC20117_RS14060	COG0084	hydrolase, TatD family'
AC20117_RS14065	COG3583	domain protein
AC20117_RS14070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AC20117_RS14075	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AC20117_RS14080	COG0488	(ABC) transporter
AC20117_RS14090	COG2226	methyltransferase
AC20117_RS14115	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AC20117_RS14150	COG0659	secondary active sulfate transmembrane transporter activity
AC20117_RS14155	COG0542	response to heat
AC20117_RS14170	COG4566	intracellular signal transduction
AC20117_RS14180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC20117_RS14185	COG0726	polysaccharide deacetylase
AC20117_RS14225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC20117_RS14250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AC20117_RS14255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AC20117_RS14290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_RS14295	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AC20117_RS14300	COG0251	oxidation-reduction process
AC20117_RS14305	COG0477	Major facilitator Superfamily
AC20117_RS14340	COG0569	domain protein
AC20117_RS14345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AC20117_RS14370	COG3559	Exporter of polyketide antibiotics
AC20117_RS14375	COG1131	(ABC) transporter
AC20117_RS14385	COG2197	response regulator
AC20117_RS14390	COG0596	Alpha beta hydrolase
AC20117_RS14415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC20117_RS14460	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS14470	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AC20117_RS14490	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AC20117_RS14510	COG1953	Uracil, thiamine, allantoin
AC20117_RS14515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_RS14570	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS14590	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AC20117_RS14615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AC20117_RS14625	COG0489	protein tyrosine kinase activity
AC20117_RS14625	COG3206	protein involved in exopolysaccharide biosynthesis
AC20117_RS14630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AC20117_RS14635	COG0193	aminoacyl-tRNA hydrolase activity
AC20117_RS14645	COG0822	iron-sulfur transferase activity
AC20117_RS14670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC20117_RS14675	COG0438	transferase activity, transferring glycosyl groups
AC20117_RS14735	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AC20117_RS14740	COG1088	dTDP-glucose 4,6-dehydratase activity
AC20117_RS14770	COG2271	Major facilitator Superfamily
AC20117_RS14785	COG5002	protein histidine kinase activity
AC20117_RS14800	COG1846	Transcriptional regulator
AC20117_RS14805	COG2815	serine threonine protein kinase
AC20117_RS14805	COG0515	serine threonine protein kinase
AC20117_RS14825	COG2354	Protein conserved in bacteria
AC20117_RS14835	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AC20117_RS14840	COG4214	carbohydrate transport
AC20117_RS14850	COG4213	ABC transporter substrate-binding protein
AC20117_RS14855	COG3328	transposase activity
AC20117_RS14860	COG1063	alcohol dehydrogenase
AC20117_RS14890	COG3835	regulator
AC20117_RS14900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AC20117_RS14935	COG1126	abc transporter atp-binding protein
AC20117_RS14940	COG0765	amino acid transport
AC20117_RS14955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC20117_RS14975	COG0402	S-adenosylhomocysteine deaminase activity
AC20117_RS14980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC20117_RS14985	COG1126	abc transporter atp-binding protein
AC20117_RS14990	COG0765	amino acid transport
AC20117_RS15000	COG1522	sequence-specific DNA binding
AC20117_RS15040	COG0583	DNA-binding transcription factor activity
AC20117_RS15045	COG2076	Multidrug Resistance protein
AC20117_RS15055	COG2124	cytochrome p450
AC20117_RS15075	COG5002	protein histidine kinase activity
AC20117_RS15100	COG0179	Fumarylacetoacetate (FAA) hydrolase
AC20117_RS15115	COG4948	Mandelate Racemase Muconate Lactonizing
AC20117_RS15120	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AC20117_RS15130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC20117_RS15145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC20117_RS15150	COG1126	abc transporter atp-binding protein
AC20117_RS15160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_RS15165	COG0583	DNA-binding transcription factor activity
AC20117_RS15170	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC20117_RS15175	COG2368	4-hydroxyphenylacetate
AC20117_RS15195	COG1027	Aspartate ammonia-lyase
AC20117_RS15200	COG1309	transcriptional regulator
AC20117_RS15205	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_RS15210	COG0531	amino acid
AC20117_RS15245	COG2207	Transcriptional regulator
AC20117_RS15265	COG4932	domain protein
AC20117_RS15265	COG3266	domain, Protein
AC20117_RS15265	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AC20117_RS15275	COG1404	Belongs to the peptidase S8 family
AC20117_RS15285	COG5634	Uncharacterized conserved protein (DUF2278)
AC20117_RS15300	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AC20117_RS15310	COG2815	serine threonine protein kinase
AC20117_RS15310	COG0515	serine threonine protein kinase
AC20117_RS15320	COG0596	Alpha beta hydrolase
AC20117_RS15330	COG3485	protocatechuate 3,4-dioxygenase
AC20117_RS15335	COG0667	Aldo Keto reductase
AC20117_RS15345	COG4214	carbohydrate transport
AC20117_RS15355	COG4213	ABC transporter substrate-binding protein
AC20117_RS15360	COG1414	Transcriptional regulator
AC20117_RS15375	COG0673	inositol 2-dehydrogenase activity
AC20117_RS15385	COG0673	inositol 2-dehydrogenase activity
AC20117_RS15405	COG2814	Major facilitator Superfamily
AC20117_RS15410	COG1940	carbohydrate kinase activity
AC20117_RS15420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC20117_RS15430	COG3962	Belongs to the TPP enzyme family
AC20117_RS15440	COG1082	Xylose isomerase domain protein TIM barrel
AC20117_RS15445	COG0673	inositol 2-dehydrogenase activity
AC20117_RS15450	COG1082	Xylose isomerase domain protein TIM barrel
AC20117_RS15455	COG2814	Major facilitator Superfamily
AC20117_RS15465	COG2814	Major facilitator Superfamily
AC20117_RS15470	COG1609	Transcriptional regulator
AC20117_RS15475	COG1942	4-Oxalocrotonate Tautomerase
AC20117_RS15480	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS15495	COG3718	enzyme involved in inositol metabolism
AC20117_RS15510	COG1172	Belongs to the binding-protein-dependent transport system permease family
AC20117_RS15520	COG0673	inositol 2-dehydrogenase activity
AC20117_RS15530	COG0673	inositol 2-dehydrogenase activity
AC20117_RS15540	COG0673	inositol 2-dehydrogenase activity
AC20117_RS15545	COG1609	Transcriptional regulator
AC20117_RS15550	COG2271	Major facilitator Superfamily
AC20117_RS15565	COG2326	polyphosphate kinase activity
AC20117_RS15580	COG0514	ATP-dependent DNA helicase (RecQ)
AC20117_RS15585	COG1522	sequence-specific DNA binding
AC20117_RS15655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC20117_RS15670	COG0471	metal ion transport
AC20117_RS15700	COG5401	PFAM Sporulation and spore germination
AC20117_RS15720	COG1404	Belongs to the peptidase S8 family
AC20117_RS15755	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AC20117_RS15765	COG2234	aminopeptidase activity
AC20117_RS15765	COG4935	Belongs to the peptidase S8 family
AC20117_RS15780	COG5002	protein histidine kinase activity
AC20117_RS15785	COG0745	RESPONSE REGULATOR receiver
AC20117_RS15795	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AC20117_RS15805	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AC20117_RS15810	COG5002	protein histidine kinase activity
AC20117_RS15820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AC20117_RS15860	COG1648	precorrin-2 dehydrogenase activity
AC20117_RS15860	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AC20117_RS15865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC20117_RS15880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC20117_RS15890	COG0484	heat shock protein binding
AC20117_RS15920	COG2814	Major facilitator Superfamily
AC20117_RS15925	COG0477	Major facilitator Superfamily
AC20117_RS15930	COG2261	transglycosylase associated protein
AC20117_RS15935	COG2385	sporulation resulting in formation of a cellular spore
AC20117_RS15935	COG2247	cell wall binding repeat
AC20117_RS15940	COG4770	biotin carboxylase activity
AC20117_RS15945	COG0515	serine threonine protein kinase
AC20117_RS15945	COG2815	serine threonine protein kinase
AC20117_RS15955	COG0424	maF-like protein
AC20117_RS15960	COG1823	symporter activity
AC20117_RS15985	COG0702	epimerase
AC20117_RS15995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AC20117_RS16040	COG0714	Associated with various cellular activities
AC20117_RS16080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AC20117_RS16100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AC20117_RS16105	COG0154	amidase activity
AC20117_RS16110	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AC20117_RS16120	COG0438	transferase activity, transferring glycosyl groups
AC20117_RS16150	COG2124	cytochrome p450
AC20117_RS16155	COG1063	alcohol dehydrogenase
AC20117_RS16160	COG0156	8-amino-7-oxononanoate synthase activity
AC20117_RS16175	COG2986	histidine ammonia-lyase
AC20117_RS16190	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AC20117_RS16205	COG1228	amidohydrolase
AC20117_RS16225	COG2873	o-acetylhomoserine
AC20117_RS16230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC20117_RS16240	COG2755	lipolytic protein G-D-S-L family
AC20117_RS16250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AC20117_RS16280	COG0423	glycine-tRNA ligase activity
AC20117_RS16305	COG0358	DNA primase activity
AC20117_RS16315	COG2723	6-phospho-beta-galactosidase activity
AC20117_RS16350	COG0052	Belongs to the universal ribosomal protein uS2 family
AC20117_RS16355	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AC20117_RS16360	COG0528	UMP kinase activity
AC20117_RS16365	COG0233	cytoplasmic translational termination
AC20117_RS16380	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC20117_RS16390	COG3279	Response regulator of the LytR AlgR family
AC20117_RS16395	COG3275	phosphorelay sensor kinase activity
AC20117_RS16405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC20117_RS16410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC20117_RS16420	COG1522	sequence-specific DNA binding
AC20117_RS16430	COG0022	dehydrogenase e1 component
AC20117_RS16435	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC20117_RS16445	COG1309	transcriptional regulator
AC20117_RS16450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AC20117_RS16460	COG1960	acyl-CoA dehydrogenase activity
AC20117_RS16490	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AC20117_RS16495	COG0750	zinc metalloprotease
AC20117_RS16510	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AC20117_RS16520	COG0442	prolyl-tRNA aminoacylation
AC20117_RS16540	COG0779	Required for maturation of 30S ribosomal subunits
AC20117_RS16555	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AC20117_RS16555	COG0481	GTPase activity
AC20117_RS16560	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AC20117_RS16570	COG0590	tRNA wobble adenosine to inosine editing
AC20117_RS16575	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AC20117_RS16595	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AC20117_RS16600	COG1185	polyribonucleotide nucleotidyltransferase activity
AC20117_RS16605	COG0612	Peptidase, M16
AC20117_RS16610	COG1115	amino acid carrier protein
AC20117_RS16625	COG3585	molybdate ion transport
AC20117_RS16655	COG0315	cyclic pyranopterin monophosphate synthase activity
AC20117_RS16660	COG0315	cyclic pyranopterin monophosphate synthase activity
AC20117_RS16660	COG0521	Mo-molybdopterin cofactor biosynthetic process
AC20117_RS16670	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AC20117_RS16685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC20117_RS16690	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AC20117_RS16695	COG1674	ftsk spoiiie
AC20117_RS16705	COG1546	Belongs to the CinA family
AC20117_RS16705	COG1058	Belongs to the CinA family
AC20117_RS16710	COG1396	sequence-specific DNA binding
AC20117_RS16725	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AC20117_RS16730	COG2137	regulation of response to DNA damage stimulus
AC20117_RS16735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AC20117_RS16740	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AC20117_RS16745	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AC20117_RS16750	COG2813	Specifically methylates the guanine in position
AC20117_RS16755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AC20117_RS16765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC20117_RS16775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC20117_RS16780	COG0131	Imidazoleglycerol-phosphate dehydratase
AC20117_RS16785	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AC20117_RS16790	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AC20117_RS16805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AC20117_RS16810	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AC20117_RS16815	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AC20117_RS16820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC20117_RS16830	COG2814	Major facilitator Superfamily
AC20117_RS16835	COG0494	nUDIX hydrolase
AC20117_RS16855	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AC20117_RS16860	COG0072	phenylalanine-tRNA ligase activity
AC20117_RS16860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC20117_RS16885	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AC20117_RS16890	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AC20117_RS16895	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AC20117_RS16900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AC20117_RS16905	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AC20117_RS16910	COG1438	arginine binding
AC20117_RS16915	COG0137	argininosuccinate synthase activity
AC20117_RS16920	COG0165	Argininosuccinate lyase
AC20117_RS16930	COG2094	Belongs to the DNA glycosylase MPG family
AC20117_RS16935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AC20117_RS16945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AC20117_RS16970	COG0647	UMP catabolic process
AC20117_RS16985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AC20117_RS16990	COG0497	DNA recombination
AC20117_RS16995	COG0504	CTP synthase activity
AC20117_RS17010	COG1051	belongs to the nudix hydrolase family
AC20117_RS17020	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AC20117_RS17025	COG2079	MmgE PrpD family protein
AC20117_RS17045	COG3290	protein histidine kinase activity
AC20117_RS17050	COG1301	dicarboxylic acid transport
AC20117_RS17060	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AC20117_RS17065	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AC20117_RS17080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AC20117_RS17085	COG1160	GTP binding
AC20117_RS17100	COG0509	glycine decarboxylation via glycine cleavage system
AC20117_RS17105	COG1716	ATPase activity
AC20117_RS17130	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AC20117_RS17165	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AC20117_RS17170	COG0515	serine threonine protein kinase
AC20117_RS17170	COG2815	serine threonine protein kinase
AC20117_RS17175	COG1388	LysM domain
AC20117_RS17175	COG1705	Flagellar rod assembly protein muramidase FlgJ
AC20117_RS17185	COG0142	geranyltranstransferase activity
AC20117_RS17190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AC20117_RS17200	COG2001	Belongs to the MraZ family
AC20117_RS17205	COG0275	rRNA processing
AC20117_RS17215	COG0768	penicillin binding
AC20117_RS17220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AC20117_RS17225	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AC20117_RS17230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AC20117_RS17235	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AC20117_RS17245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AC20117_RS17250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AC20117_RS17260	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AC20117_RS17270	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AC20117_RS17275	COG1799	cell septum assembly
AC20117_RS17290	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AC20117_RS17300	COG0587	DNA-directed DNA polymerase activity
AC20117_RS17310	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AC20117_RS17315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AC20117_RS17330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AC20117_RS17340	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AC20117_RS17345	COG0765	amino acid transport
AC20117_RS17350	COG1126	abc transporter atp-binding protein
AC20117_RS17375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AC20117_RS17380	COG0321	lipoyl(octanoyl) transferase activity
AC20117_RS17390	COG1090	epimerase
AC20117_RS17395	COG4946	Tricorn protease homolog
AC20117_RS17395	COG0793	Belongs to the peptidase S41A family
AC20117_RS17410	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC20117_RS17415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC20117_RS17420	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AC20117_RS17440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AC20117_RS17450	COG0187	DNA topoisomerase II activity
AC20117_RS17465	COG1271	oxidase subunit
AC20117_RS17470	COG1294	oxidase, subunit
AC20117_RS17475	COG4988	ABC transporter
AC20117_RS17495	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AC20117_RS17530	COG0756	dUTP diphosphatase activity
AC20117_RS17555	COG0569	domain protein
AC20117_RS17560	COG0531	amino acid
AC20117_RS17565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AC20117_RS17570	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AC20117_RS17575	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AC20117_RS17580	COG3557	Belongs to the UPF0374 family
AC20117_RS17590	COG3663	DNA glycosylase
AC20117_RS17595	COG0137	argininosuccinate synthase activity
AC20117_RS17600	COG0667	Aldo Keto reductase
AC20117_RS17625	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC20117_RS17625	COG1024	Enoyl-CoA hydratase
AC20117_RS17630	COG0183	Belongs to the thiolase family
AC20117_RS17635	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AC20117_RS17660	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AC20117_RS17675	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AC20117_RS17700	COG3328	transposase activity
AC20117_RS17745	COG0242	peptide deformylase activity
AC20117_RS17750	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AC20117_RS17760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AC20117_RS17780	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AC20117_RS17780	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AC20117_RS17790	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AC20117_RS17795	COG0140	phosphoribosyl-ATP diphosphatase activity
AC20117_RS17800	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AC20117_RS17805	COG0107	imidazoleglycerol-phosphate synthase activity
AC20117_RS17815	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AC20117_RS17835	COG0134	indole-3-glycerol-phosphate synthase activity
AC20117_RS17840	COG0133	tryptophan synthase activity
AC20117_RS17845	COG0159	tryptophan synthase activity
AC20117_RS17850	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AC20117_RS17855	COG0069	glutamate synthase activity
AC20117_RS17855	COG0070	glutamate synthase
AC20117_RS17855	COG0067	glutamate synthase
AC20117_RS17865	COG0469	pyruvate kinase activity
AC20117_RS17900	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AC20117_RS17915	COG1793	dna ligase
AC20117_RS17915	COG3285	dna ligase
AC20117_RS17930	COG0477	Major facilitator Superfamily
AC20117_RS17935	COG1643	Atp-dependent helicase
AC20117_RS17960	COG0009	L-threonylcarbamoyladenylate synthase
AC20117_RS17970	COG0174	glutamine synthetase
AC20117_RS18000	COG2050	protein possibly involved in aromatic compounds catabolism
AC20117_RS18015	COG4552	Acetyltransferase involved in intracellular survival and related
AC20117_RS18020	COG0539	negative regulation of cytoplasmic translation
AC20117_RS18030	COG1739	Uncharacterized protein family UPF0029
AC20117_RS18035	COG0237	dephospho-CoA kinase activity
AC20117_RS18035	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AC20117_RS18040	COG0477	Major facilitator Superfamily
AC20117_RS18045	COG0556	nucleotide-excision repair
AC20117_RS18055	COG0477	Major facilitator Superfamily
AC20117_RS18075	COG4106	trans-aconitate 2-methyltransferase activity
AC20117_RS18085	COG1725	Transcriptional regulator
AC20117_RS18100	COG0318	PFAM AMP-dependent synthetase and ligase
AC20117_RS18100	COG0204	Acyl-transferase
AC20117_RS18105	COG0322	excinuclease ABC activity
AC20117_RS18110	COG1660	Displays ATPase and GTPase activities
AC20117_RS18115	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AC20117_RS18120	COG1481	regulation of sporulation
AC20117_RS18125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AC20117_RS18135	COG0126	phosphoglycerate kinase activity
AC20117_RS18140	COG0149	triose-phosphate isomerase activity
AC20117_RS18145	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AC20117_RS18155	COG0363	glucosamine-6-phosphate deaminase activity
AC20117_RS18170	COG0166	Belongs to the GPI family
AC20117_RS18175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AC20117_RS18185	COG0109	protoheme IX farnesyltransferase activity
AC20117_RS18190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC20117_RS18205	COG1131	(ABC) transporter
AC20117_RS18230	COG0396	ATPase activity
AC20117_RS18235	COG2151	metal-sulfur cluster biosynthetic enzyme
AC20117_RS18255	COG1122	ATPase activity
AC20117_RS18260	COG1268	BioY protein
AC20117_RS18265	COG0488	(ABC) transporter
AC20117_RS18285	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS18290	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS18295	COG0560	Phosphoserine phosphatase
AC20117_RS18295	COG3830	Belongs to the UPF0237 family
AC20117_RS18300	COG1119	ATPase activity
AC20117_RS18315	COG0254	rRNA binding
AC20117_RS18330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC20117_RS18355	COG1305	Transglutaminase-like
AC20117_RS18360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AC20117_RS18370	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AC20117_RS18375	COG0297	glycogen (starch) synthase activity
AC20117_RS18390	COG0183	Belongs to the thiolase family
AC20117_RS18395	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS18405	COG3844	kynureninase activity
AC20117_RS18410	COG0438	transferase activity, transferring glycosyl groups
AC20117_RS18420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC20117_RS18430	COG3424	synthase
AC20117_RS18465	COG0366	Alpha amylase catalytic
AC20117_RS18505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AC20117_RS18555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC20117_RS18575	COG0667	Aldo Keto reductase
AC20117_RS18580	COG1968	undecaprenyl-diphosphatase activity
AC20117_RS18585	COG0215	cysteine-tRNA ligase activity
AC20117_RS18595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AC20117_RS18610	COG1222	aaa ATPase
AC20117_RS18615	COG4122	O-methyltransferase activity
AC20117_RS18625	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AC20117_RS18630	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AC20117_RS18635	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AC20117_RS18640	COG0545	Peptidyl-prolyl cis-trans isomerase
AC20117_RS18650	COG2378	regulation of single-species biofilm formation
AC20117_RS18660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC20117_RS18665	COG0805	protein transport
AC20117_RS18670	COG4581	dead DEAH box helicase
AC20117_RS18675	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AC20117_RS18680	COG1216	Glycosyl transferase, family 2
AC20117_RS18705	COG0823	Involved in the tonB-independent uptake of proteins
AC20117_RS18705	COG1506	peptidase
AC20117_RS18705	COG4946	Tricorn protease homolog
AC20117_RS18710	COG0242	peptide deformylase activity
AC20117_RS18720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AC20117_RS18735	COG4974	Belongs to the 'phage' integrase family
AC20117_RS18755	COG0477	Major facilitator Superfamily
AC20117_RS18790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AC20117_RS18795	COG1845	cytochrome c oxidase, subunit III
AC20117_RS18800	COG2010	Cytochrome c
AC20117_RS18805	COG0723	plastoquinol--plastocyanin reductase activity
AC20117_RS18810	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AC20117_RS18815	COG2188	Transcriptional regulator
AC20117_RS18825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AC20117_RS18830	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AC20117_RS18850	COG0167	dihydroorotate dehydrogenase activity
AC20117_RS18860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AC20117_RS18865	COG1381	Involved in DNA repair and RecF pathway recombination
AC20117_RS18870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AC20117_RS18875	COG3590	peptidase
AC20117_RS18880	COG1316	TRANSCRIPTIONal
AC20117_RS18885	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AC20117_RS18895	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AC20117_RS18915	COG0484	heat shock protein binding
AC20117_RS18920	COG1420	regulation of RNA biosynthetic process
AC20117_RS18940	COG0481	GTPase activity
AC20117_RS18950	COG0268	Binds directly to 16S ribosomal RNA
AC20117_RS18965	COG1596	polysaccharide export
AC20117_RS18965	COG1555	photosystem II stabilization
AC20117_RS18970	COG1307	EDD domain protein, DegV family
AC20117_RS18975	COG0495	leucyl-tRNA aminoacylation
AC20117_RS18980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AC20117_RS19005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AC20117_RS19015	COG1758	RNA polymerase activity
AC20117_RS19020	COG0194	GDP metabolic process
AC20117_RS19025	COG0194	GDP metabolic process
AC20117_RS19030	COG0284	orotidine-5'-phosphate decarboxylase activity
AC20117_RS19035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AC20117_RS19040	COG0505	Belongs to the CarA family
AC20117_RS19050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC20117_RS19055	COG0540	Belongs to the ATCase OTCase family
AC20117_RS19060	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AC20117_RS19065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC20117_RS19070	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AC20117_RS19075	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AC20117_RS19080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AC20117_RS19085	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AC20117_RS19090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AC20117_RS19100	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AC20117_RS19105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AC20117_RS19120	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AC20117_RS19125	COG1490	D-aminoacyl-tRNA deacylase activity
AC20117_RS19140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AC20117_RS19150	COG0124	histidyl-tRNA synthetase
AC20117_RS19155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AC20117_RS19160	COG1196	nuclear chromosome segregation
AC20117_RS19170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AC20117_RS19180	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AC20117_RS19190	COG2255	four-way junction helicase activity
AC20117_RS19195	COG0632	four-way junction helicase activity
AC20117_RS19200	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AC20117_RS19205	COG0217	transcriptional regulatory protein
AC20117_RS19210	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AC20117_RS19215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AC20117_RS19230	COG0339	signal peptide processing
AC20117_RS19240	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AC20117_RS19245	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AC20117_RS19255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AC20117_RS19260	COG0587	DNA-directed DNA polymerase activity
AC20117_RS19285	COG2135	peptidase activity
AC20117_RS19300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC20117_RS19350	COG0596	Alpha beta hydrolase
AC20117_RS19355	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AC20117_RS19365	COG2226	methyltransferase
AC20117_RS19405	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AC20117_RS19410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AC20117_RS19415	COG1780	Probably involved in ribonucleotide reductase function
AC20117_RS19420	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AC20117_RS19425	COG0583	DNA-binding transcription factor activity
AC20117_RS19455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AC20117_RS19465	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AC20117_RS19470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AC20117_RS19475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AC20117_RS19480	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AC20117_RS19485	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AC20117_RS19490	COG0352	thiamine-phosphate diphosphorylase activity
AC20117_RS19490	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AC20117_RS19490	COG0351	phosphomethylpyrimidine kinase
AC20117_RS19495	COG1530	ribonuclease E activity
AC20117_RS19505	COG0105	UTP biosynthetic process
AC20117_RS19515	COG0285	dihydrofolate synthase activity
AC20117_RS19520	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AC20117_RS19535	COG0525	valine-tRNA ligase activity
AC20117_RS19540	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AC20117_RS19545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AC20117_RS19550	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AC20117_RS19555	COG0740	serine-type endopeptidase activity
AC20117_RS19560	COG0740	serine-type endopeptidase activity
AC20117_RS19565	COG0544	peptidyl-prolyl cis-trans isomerase activity
AC20117_RS19620	COG1946	Acyl-CoA thioesterase
AC20117_RS19635	COG0629	single-stranded DNA binding
AC20117_RS19645	COG0438	transferase activity, transferring glycosyl groups
AC20117_RS19650	COG1904	glucuronate isomerase
AC20117_RS19655	COG0246	Mannitol dehydrogenase
AC20117_RS19660	COG4948	Mandelate Racemase Muconate Lactonizing
AC20117_RS19665	COG3265	gluconokinase activity
AC20117_RS19670	COG1609	Transcriptional regulator
AC20117_RS19675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC20117_RS19705	COG0438	transferase activity, transferring glycosyl groups
AC20117_RS19715	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AC20117_RS19715	COG2755	lipolytic protein G-D-S-L family
AC20117_RS19730	COG0438	transferase activity, transferring glycosyl groups
AC20117_RS19735	COG0438	transferase activity, transferring glycosyl groups
AC20117_RS19745	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AC20117_RS19750	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AC20117_RS19770	COG1134	teichoic acid transport
AC20117_RS19800	COG0242	peptide deformylase activity
AC20117_RS19825	COG3594	Acyltransferase
AC20117_RS19845	COG1579	Zn-ribbon protein possibly nucleic acid-binding
AC20117_RS19850	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AC20117_RS19855	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AC20117_RS19865	COG1045	serine acetyltransferase
AC20117_RS19875	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AC20117_RS19905	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AC20117_RS19920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC20117_RS19925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AC20117_RS19940	COG4974	Belongs to the 'phage' integrase family
AC20117_RS19955	COG0792	nuclease activity
AC20117_RS19965	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AC20117_RS19975	COG0681	Belongs to the peptidase S26 family
AC20117_RS19980	COG0335	large ribosomal subunit rRNA binding
AC20117_RS19985	COG0336	Belongs to the RNA methyltransferase TrmD family
AC20117_RS19990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AC20117_RS19995	COG1837	Belongs to the UPF0109 family
AC20117_RS20000	COG0228	four-way junction DNA binding
AC20117_RS20010	COG2514	catechol 2,3-dioxygenase activity
AC20117_RS20035	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AC20117_RS20050	COG2814	Major facilitator Superfamily
AC20117_RS20075	COG0519	Catalyzes the synthesis of GMP from XMP
AC20117_RS20075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AC20117_RS20080	COG1196	nuclear chromosome segregation
AC20117_RS20085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC20117_RS20090	COG0318	PFAM AMP-dependent synthetase and ligase
AC20117_RS20095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC20117_RS20120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AC20117_RS20125	COG0571	ribonuclease III activity
AC20117_RS20130	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AC20117_RS20140	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AC20117_RS20145	COG0436	Aminotransferase
AC20117_RS20160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AC20117_RS20165	COG1461	Dihydroxyacetone kinase
AC20117_RS20170	COG1316	TRANSCRIPTIONal
AC20117_RS20180	COG1181	Belongs to the D-alanine--D-alanine ligase family
AC20117_RS20185	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AC20117_RS20195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AC20117_RS20200	COG0066	3-isopropylmalate dehydratase activity
AC20117_RS20205	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AC20117_RS20210	COG1414	Transcriptional regulator
AC20117_RS20245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC20117_RS20255	COG2197	response regulator
AC20117_RS20270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC20117_RS20275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AC20117_RS20280	COG0473	3-isopropylmalate dehydrogenase activity
AC20117_RS20285	COG4585	Histidine kinase
AC20117_RS20290	COG2197	response regulator
AC20117_RS20320	COG0577	efflux transmembrane transporter activity
AC20117_RS20320	COG1136	(ABC) transporter
AC20117_RS20330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AC20117_RS20335	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AC20117_RS20340	COG0440	acetolactate synthase activity
AC20117_RS20350	COG0129	dihydroxy-acid dehydratase activity
AC20117_RS20370	COG2133	pyrroloquinoline quinone binding
AC20117_RS20400	COG3328	transposase activity
AC20117_RS20410	COG1278	Cold shock
AC20117_RS20455	COG0789	Transcriptional regulator
AC20117_RS20465	COG2814	Major facilitator Superfamily
AC20117_RS20470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AC20117_RS20475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AC20117_RS20480	COG0492	ferredoxin-NADP+ reductase activity
AC20117_RS20485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AC20117_RS20560	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AC20117_RS20565	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC20117_RS20575	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AC20117_RS20585	COG0713	ATP synthesis coupled electron transport
AC20117_RS20590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC20117_RS20620	COG2124	cytochrome p450
AC20117_RS20625	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AC20117_RS20645	COG3328	transposase activity
AC20117_RS20670	COG2217	Heavy metal translocating P-type atpase
AC20117_RS20675	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AC20117_RS20760	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AC20117_RS20760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC20117_RS20820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AC20117_RS20885	COG0785	Cytochrome C biogenesis protein
AC20117_RS20890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC20117_RS20900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AC20117_RS20910	COG2132	Multicopper oxidase
AC20117_RS20940	COG0739	heme binding
AC20117_RS20950	COG1937	Protein conserved in bacteria
AC20117_RS21060	COG2197	response regulator
AC20117_RS21080	COG4208	sulfate ABC transporter
AC20117_RS21085	COG3842	ATPase activity
AC20117_RS21135	COG0457	Tetratricopeptide repeat
AC20117_RS21170	COG0492	ferredoxin-NADP+ reductase activity
AC20117_RS21185	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AC20117_RS21195	COG0277	FAD linked oxidase domain protein
AC20117_RS21200	COG2267	carboxylic ester hydrolase activity
AC20117_RS21230	COG0601	transmembrane transport
AC20117_RS21235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AC20117_RS21250	COG0747	negative chemotaxis
AC20117_RS21255	COG0579	oxidoreductase
AC20117_RS21260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC20117_RS21265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_RS21275	COG1305	Transglutaminase-like
AC20117_RS21285	COG1104	cysteine desulfurase activity
AC20117_RS21295	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AC20117_RS21300	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AC20117_RS21315	COG1113	amino acid transport
AC20117_RS21325	COG0022	dehydrogenase e1 component
AC20117_RS21330	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC20117_RS21340	COG0515	serine threonine protein kinase
AC20117_RS21355	COG1802	Transcriptional regulator
AC20117_RS21385	COG3226	Transcriptional regulator
AC20117_RS21405	COG0477	Major facilitator Superfamily
AC20117_RS21420	COG0419	ATPase involved in DNA repair
AC20117_RS21425	COG0420	3'-5' exonuclease activity
AC20117_RS21440	COG1028	Short-chain dehydrogenase reductase Sdr
AC20117_RS21455	COG1131	(ABC) transporter
AC20117_RS21460	COG2188	Transcriptional regulator
AC20117_RS21470	COG0586	Pfam SNARE associated Golgi protein
AC20117_RS21475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AC20117_RS21480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AC20117_RS21485	COG1234	tRNA 3'-trailer cleavage
AC20117_RS21490	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AC20117_RS21500	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AC20117_RS21505	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AC20117_RS21510	COG1335	isochorismatase
AC20117_RS21535	COG1131	(ABC) transporter
AC20117_RS21540	COG1902	pentaerythritol trinitrate reductase activity
AC20117_RS21565	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AC20117_RS21585	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AC20117_RS21590	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AC20117_RS21595	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AC20117_RS21600	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AC20117_RS21605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AC20117_RS21610	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AC20117_RS21615	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AC20117_RS21620	COG0356	it plays a direct role in the translocation of protons across the membrane
AC20117_RS21640	COG1086	Polysaccharide biosynthesis protein
AC20117_RS21650	COG2890	protein-(glutamine-N5) methyltransferase activity
AC20117_RS21655	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AC20117_RS21665	COG0083	homoserine kinase activity
AC20117_RS21670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AC20117_RS21675	COG0460	homoserine dehydrogenase
AC20117_RS21680	COG0019	diaminopimelate decarboxylase activity
AC20117_RS21685	COG0018	arginyl-trna synthetase
AC20117_RS21710	COG1122	ATPase activity
AC20117_RS21725	COG1643	Atp-dependent helicase
AC20117_RS21730	COG0537	adenosine 5'-monophosphoramidase activity
AC20117_RS21735	COG1064	alcohol dehydrogenase
AC20117_RS21755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AC20117_RS21760	COG1121	(ABC) transporter
AC20117_RS21765	COG0803	Belongs to the bacterial solute-binding protein 9 family
AC20117_RS21775	COG1253	flavin adenine dinucleotide binding
AC20117_RS21785	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC20117_RS21785	COG0567	Dehydrogenase, E1 component
AC20117_RS21800	COG1595	DNA-templated transcription, initiation
AC20117_RS21810	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AC20117_RS21820	COG0483	inositol monophosphate 1-phosphatase activity
AC20117_RS21825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AC20117_RS21835	COG0803	Belongs to the bacterial solute-binding protein 9 family
AC20117_RS21840	COG1121	(ABC) transporter
AC20117_RS21845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AC20117_RS21855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AC20117_RS21860	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AC20117_RS21865	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AC20117_RS21885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AC20117_RS21900	COG2884	Cell division ATP-binding protein ftsE
AC20117_RS21910	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AC20117_RS22075	COG1129	ABC transporter
AC20117_RS22080	COG1172	Belongs to the binding-protein-dependent transport system permease family
AC20117_RS22100	COG0154	amidase activity
AC20117_RS22105	COG1414	Transcriptional regulator
AC20117_RS22130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_RS22135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_RS22140	COG1116	anion transmembrane transporter activity
AC20117_RS22160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC20117_RS22175	COG0656	L-ascorbic acid biosynthetic process
AC20117_RS22180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC20117_RS22240	COG2856	Zn peptidase
AC20117_RS22265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AC20117_RS22265	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC20117_RS22270	COG2188	Transcriptional regulator
AC20117_RS22285	COG2814	Major facilitator Superfamily
AC20117_RS22290	COG1937	Protein conserved in bacteria
AC20117_RS22295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AC20117_RS22310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC20117_RS22330	COG1253	flavin adenine dinucleotide binding
AC20117_RS22335	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AC20117_RS22340	COG0530	calcium, potassium:sodium antiporter activity
AC20117_RS22380	COG1192	Involved in chromosome partitioning
AC20117_RS22495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_RS22520	COG1609	Transcriptional regulator
AC20117_RS22525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC20117_RS22530	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AC20117_RS22575	COG0066	3-isopropylmalate dehydratase activity
AC20117_RS22580	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AC20117_RS22585	COG0473	3-isopropylmalate dehydrogenase activity
AC20117_RS22590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_RS22595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_RS22605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC20117_RS22670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_RS22680	COG1335	isochorismatase
AC20117_RS22690	COG0656	L-ascorbic acid biosynthetic process
AC20117_RS22695	COG4638	Rieske (2fe-2S)
AC20117_RS22750	COG4974	Belongs to the 'phage' integrase family
AC20117_RS22840	COG1053	succinate dehydrogenase
AC20117_RS22885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC20117_RS22890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC20117_RS22890	COG1116	anion transmembrane transporter activity
AC20117_RS22895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC20117_RS22900	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AC20117_RS22905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC20117_RS22925	COG0252	asparaginase activity
AC20117_RS22935	COG0318	PFAM AMP-dependent synthetase and ligase
AC20117_RS22945	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AC20117_RS22950	COG3328	transposase activity
AC20117_RS22970	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_RS22990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC20117_RS23000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC20117_RS23015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC20117_RS23020	COG1012	belongs to the aldehyde dehydrogenase family
AC20117_RS23070	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AC20117_RS23155	COG1129	ABC transporter