locus-tag	class	description
DMB86_RS00035	COG1652	LysM domain
DMB86_RS00065	COG0346	lactoylglutathione lyase activity
DMB86_RS00075	COG1012	belongs to the aldehyde dehydrogenase family
DMB86_RS00080	COG0583	DNA-binding transcription factor activity
DMB86_RS00095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMB86_RS00100	COG2814	Major facilitator Superfamily
DMB86_RS00135	COG1666	GTP binding
DMB86_RS00145	COG2197	response regulator
DMB86_RS00150	COG4585	Histidine kinase
DMB86_RS00155	COG0406	alpha-ribazole phosphatase activity
DMB86_RS00160	COG0501	Belongs to the peptidase M48B family
DMB86_RS00175	COG0753	catalase activity
DMB86_RS00195	COG0531	amino acid
DMB86_RS00210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DMB86_RS00240	COG1012	belongs to the aldehyde dehydrogenase family
DMB86_RS00255	COG1648	precorrin-2 dehydrogenase activity
DMB86_RS00255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DMB86_RS00265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DMB86_RS00270	COG1116	anion transmembrane transporter activity
DMB86_RS00320	COG2895	sulfate adenylyltransferase (ATP) activity
DMB86_RS00330	COG0175	sulfate reduction
DMB86_RS00335	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DMB86_RS00355	COG4152	abc transporter atp-binding protein
DMB86_RS00360	COG2860	membrane
DMB86_RS00370	COG0142	geranyltranstransferase activity
DMB86_RS00380	COG2226	methyltransferase
DMB86_RS00385	COG1169	isochorismate synthase
DMB86_RS00390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DMB86_RS00395	COG0765	amino acid transport
DMB86_RS00400	COG1126	abc transporter atp-binding protein
DMB86_RS00405	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DMB86_RS00410	COG4948	Mandelate Racemase Muconate Lactonizing
DMB86_RS00440	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMB86_RS00460	COG0531	amino acid
DMB86_RS00465	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DMB86_RS00475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DMB86_RS00480	COG2151	metal-sulfur cluster biosynthetic enzyme
DMB86_RS00485	COG3396	Phenylacetate-CoA oxygenase
DMB86_RS00490	COG3460	Phenylacetate-CoA oxygenase
DMB86_RS00495	COG3396	Phenylacetate-CoA oxygenase
DMB86_RS00500	COG2050	protein possibly involved in aromatic compounds catabolism
DMB86_RS00520	COG1012	belongs to the aldehyde dehydrogenase family
DMB86_RS00520	COG2030	dehydratase
DMB86_RS00525	COG1250	3-hydroxyacyl-CoA dehydrogenase
DMB86_RS00530	COG1024	Enoyl-CoA hydratase
DMB86_RS00555	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DMB86_RS00560	COG0857	belongs to the CobB CobQ family
DMB86_RS00560	COG0280	phosphate acetyltransferase
DMB86_RS00580	COG2197	response regulator
DMB86_RS00585	COG4585	Histidine kinase
DMB86_RS00595	COG1131	(ABC) transporter
DMB86_RS00610	COG0653	protein targeting
DMB86_RS00615	COG2365	Tyrosine phosphatase family
DMB86_RS00630	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DMB86_RS00665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DMB86_RS00675	COG0785	Cytochrome C biogenesis protein
DMB86_RS00680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMB86_RS00685	COG0406	alpha-ribazole phosphatase activity
DMB86_RS00690	COG2353	YceI-like domain
DMB86_RS00700	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DMB86_RS00725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DMB86_RS00730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DMB86_RS00735	COG1113	amino acid transport
DMB86_RS00740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DMB86_RS00750	COG0123	including yeast histone deacetylase and acetoin utilization protein
DMB86_RS00755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DMB86_RS00760	COG0569	domain protein
DMB86_RS00765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DMB86_RS00770	COG1595	DNA-templated transcription, initiation
DMB86_RS00775	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DMB86_RS00780	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DMB86_RS00810	COG1175	transmembrane transport
DMB86_RS00815	COG0395	ABC-type sugar transport system, permease component
DMB86_RS00825	COG3119	arylsulfatase activity
DMB86_RS00850	COG1082	Xylose isomerase domain protein TIM barrel
DMB86_RS00855	COG0248	Ppx GppA phosphatase
DMB86_RS00860	COG1754	DNA topoisomerase type I activity
DMB86_RS00860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DMB86_RS00865	COG1285	pathogenesis
DMB86_RS00870	COG2890	protein-(glutamine-N5) methyltransferase activity
DMB86_RS00875	COG1054	Belongs to the UPF0176 family
DMB86_RS00885	COG1205	dead DEAH box helicase
DMB86_RS00885	COG1111	helicase
DMB86_RS00945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DMB86_RS00960	COG1175	transmembrane transport
DMB86_RS00965	COG0395	ABC-type sugar transport system, permease component
DMB86_RS00970	COG1349	DNA-binding transcription factor activity
DMB86_RS00985	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DMB86_RS01005	COG0251	oxidation-reduction process
DMB86_RS01015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DMB86_RS01020	COG1408	metallophosphoesterase
DMB86_RS01030	COG0531	amino acid
DMB86_RS01045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DMB86_RS01050	COG0151	Belongs to the GarS family
DMB86_RS01090	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DMB86_RS01105	COG0542	response to heat
DMB86_RS01130	COG0667	Aldo Keto reductase
DMB86_RS01175	COG1473	amidohydrolase
DMB86_RS01180	COG0477	Major facilitator Superfamily
DMB86_RS01185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DMB86_RS01195	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DMB86_RS01200	COG0789	Transcriptional regulator
DMB86_RS01205	COG0484	heat shock protein binding
DMB86_RS01210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DMB86_RS01215	COG0443	Heat shock 70 kDa protein
DMB86_RS01230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DMB86_RS01235	COG1280	lysine exporter protein (LysE YggA)
DMB86_RS01240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DMB86_RS01250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DMB86_RS01265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DMB86_RS01275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DMB86_RS01285	COG1122	ATPase activity
DMB86_RS01290	COG4721	ABC-type cobalt transport system, permease component
DMB86_RS01300	COG1320	monovalent cation:proton antiporter activity
DMB86_RS01305	COG2212	antiporter activity
DMB86_RS01310	COG1863	multisubunit Na H antiporter MnhE subunit
DMB86_RS01315	COG0651	ATP synthesis coupled electron transport
DMB86_RS01320	COG1006	Multisubunit Na H antiporter MnhC subunit
DMB86_RS01325	COG2111	Na H antiporter
DMB86_RS01325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DMB86_RS01335	COG0717	Belongs to the dCTP deaminase family
DMB86_RS01345	COG0475	glutathione-regulated potassium exporter activity
DMB86_RS01370	COG3239	Fatty acid desaturase
DMB86_RS01385	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DMB86_RS01400	COG0433	COG0433 Predicted ATPase
DMB86_RS01425	COG0776	regulation of translation
DMB86_RS01435	COG0366	Alpha amylase catalytic
DMB86_RS01440	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DMB86_RS01445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DMB86_RS01450	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DMB86_RS01465	COG1132	(ABC) transporter
DMB86_RS01475	COG2764	glyoxalase bleomycin resistance protein dioxygenase
DMB86_RS01505	COG0435	Glutathione S-transferase
DMB86_RS01515	COG1174	glycine betaine transport
DMB86_RS01565	COG0277	FAD linked oxidase domain protein
DMB86_RS01570	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DMB86_RS01615	COG0673	inositol 2-dehydrogenase activity
DMB86_RS01645	COG2233	PERMEase
DMB86_RS01650	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS01655	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DMB86_RS01665	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DMB86_RS01665	COG2080	2 iron, 2 sulfur cluster binding
DMB86_RS01675	COG2252	PERMEase
DMB86_RS01680	COG0590	tRNA wobble adenosine to inosine editing
DMB86_RS01690	COG1414	Transcriptional regulator
DMB86_RS01700	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DMB86_RS01710	COG3257	ureidoglycine aminohydrolase activity
DMB86_RS01715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DMB86_RS01725	COG3622	Belongs to the hyi family
DMB86_RS01730	COG2084	Dehydrogenase
DMB86_RS01735	COG3960	tartronate-semialdehyde synthase activity
DMB86_RS01740	COG1929	Belongs to the glycerate kinase type-1 family
DMB86_RS01745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DMB86_RS01760	COG0686	Belongs to the AlaDH PNT family
DMB86_RS01780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DMB86_RS01795	COG0582	viral genome integration into host DNA
DMB86_RS01800	COG4974	Belongs to the 'phage' integrase family
DMB86_RS01820	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMB86_RS01825	COG0022	dehydrogenase e1 component
DMB86_RS01835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DMB86_RS01840	COG1950	PFAM Membrane protein of
DMB86_RS01855	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DMB86_RS01865	COG0436	Aminotransferase
DMB86_RS01885	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DMB86_RS01900	COG0028	Belongs to the TPP enzyme family
DMB86_RS01910	COG0246	Mannitol dehydrogenase
DMB86_RS01915	COG2213	PTS system mannitol-specific
DMB86_RS01915	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DMB86_RS01925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DMB86_RS01930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DMB86_RS01930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DMB86_RS01945	COG1937	Protein conserved in bacteria
DMB86_RS01950	COG2608	mercury ion transmembrane transporter activity
DMB86_RS01970	COG0395	ABC-type sugar transport system, permease component
DMB86_RS01975	COG1175	transmembrane transport
DMB86_RS01980	COG1653	transport
DMB86_RS01985	COG4821	SIS domain
DMB86_RS02030	COG0359	binds to the 23S rRNA
DMB86_RS02035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DMB86_RS02045	COG0360	Binds together with S18 to 16S ribosomal RNA
DMB86_RS02060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DMB86_RS02065	COG1362	aminopeptidase activity
DMB86_RS02075	COG2197	response regulator
DMB86_RS02080	COG4585	Histidine kinase
DMB86_RS02100	COG0738	Major facilitator superfamily
DMB86_RS02115	COG0488	(ABC) transporter
DMB86_RS02125	COG2814	Major facilitator Superfamily
DMB86_RS02135	COG2197	response regulator
DMB86_RS02145	COG0577	efflux transmembrane transporter activity
DMB86_RS02150	COG1136	(ABC) transporter
DMB86_RS02165	COG1733	regulation of RNA biosynthetic process
DMB86_RS02210	COG0406	alpha-ribazole phosphatase activity
DMB86_RS02215	COG0617	tRNA 3'-terminal CCA addition
DMB86_RS02235	COG0492	ferredoxin-NADP+ reductase activity
DMB86_RS02240	COG3118	belongs to the thioredoxin family
DMB86_RS02260	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DMB86_RS02280	COG1192	Involved in chromosome partitioning
DMB86_RS02285	COG0357	Ribosomal RNA small subunit methyltransferase G
DMB86_RS02295	COG0706	membrane insertase activity
DMB86_RS02300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DMB86_RS02305	COG0594	ribonuclease P activity
DMB86_RS02310	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DMB86_RS02315	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DMB86_RS02320	COG0592	DNA-directed DNA polymerase activity
DMB86_RS02325	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DMB86_RS02330	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DMB86_RS02335	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DMB86_RS02340	COG0187	DNA topoisomerase II activity
DMB86_RS02345	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DMB86_RS02350	COG3266	domain, Protein
DMB86_RS02380	COG0705	Rhomboid family
DMB86_RS02390	COG2197	response regulator
DMB86_RS02405	COG3764	Sortase (surface protein transpeptidase)
DMB86_RS02415	COG2815	serine threonine protein kinase
DMB86_RS02415	COG0515	serine threonine protein kinase
DMB86_RS02420	COG0515	serine threonine protein kinase
DMB86_RS02440	COG1716	ATPase activity
DMB86_RS02445	COG1716	ATPase activity
DMB86_RS02495	COG1254	Belongs to the acylphosphatase family
DMB86_RS02550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DMB86_RS02565	COG2186	Transcriptional regulator
DMB86_RS02570	COG1620	l-lactate permease
DMB86_RS02575	COG0247	lactate metabolic process
DMB86_RS02580	COG1139	Iron-sulfur cluster binding protein
DMB86_RS02585	COG1556	Lactate utilization protein
DMB86_RS02595	COG1063	alcohol dehydrogenase
DMB86_RS02600	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DMB86_RS02610	COG1256	bacterial-type flagellum assembly
DMB86_RS02610	COG4786	Flagellar basal body rod
DMB86_RS02645	COG1815	bacterial-type flagellum-dependent cell motility
DMB86_RS02655	COG1677	Flagellar hook-basal body complex protein FliE
DMB86_RS02660	COG1766	The M ring may be actively involved in energy transduction
DMB86_RS02665	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DMB86_RS02675	COG1157	protein secretion by the type III secretion system
DMB86_RS02690	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DMB86_RS02710	COG1360	Flagellar Motor Protein
DMB86_RS02730	COG1338	Plays a role in the flagellum-specific transport system
DMB86_RS02745	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DMB86_RS02750	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DMB86_RS02760	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DMB86_RS02810	COG1012	belongs to the aldehyde dehydrogenase family
DMB86_RS02815	COG0385	Bile acid
DMB86_RS02840	COG0584	glycerophosphoryl diester phosphodiesterase
DMB86_RS02845	COG1929	Belongs to the glycerate kinase type-1 family
DMB86_RS02850	COG2233	PERMEase
DMB86_RS02875	COG3104	oligopeptide transport
DMB86_RS02880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DMB86_RS02895	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DMB86_RS02900	COG0561	phosphatase activity
DMB86_RS02910	COG2027	D-alanyl-D-alanine carboxypeptidase
DMB86_RS02920	COG0037	tRNA processing
DMB86_RS02930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DMB86_RS02935	COG0302	gtp cyclohydrolase
DMB86_RS02945	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DMB86_RS02975	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DMB86_RS02980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DMB86_RS02985	COG0477	Major facilitator Superfamily
DMB86_RS02990	COG1957	nucleoside hydrolase
DMB86_RS02995	COG1609	Transcriptional regulator
DMB86_RS03000	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DMB86_RS03015	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DMB86_RS03020	COG2376	Dihydroxyacetone kinase
DMB86_RS03025	COG1461	Dihydroxyacetone kinase
DMB86_RS03030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DMB86_RS03030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DMB86_RS03030	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DMB86_RS03045	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DMB86_RS03070	COG0477	Major facilitator Superfamily
DMB86_RS03075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DMB86_RS03090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DMB86_RS03115	COG0351	phosphomethylpyrimidine kinase
DMB86_RS03125	COG0300	oxidoreductase activity
DMB86_RS03150	COG0477	Major facilitator Superfamily
DMB86_RS03155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DMB86_RS03160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DMB86_RS03160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DMB86_RS03160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DMB86_RS03190	COG2733	membrane
DMB86_RS03195	COG0584	glycerophosphoryl diester phosphodiesterase
DMB86_RS03200	COG3387	PFAM Glycoside hydrolase 15-related
DMB86_RS03225	COG4122	O-methyltransferase activity
DMB86_RS03270	COG2252	PERMEase
DMB86_RS03290	COG3883	PFAM NLP P60 protein
DMB86_RS03290	COG0791	NLP P60 protein
DMB86_RS03365	COG1609	Transcriptional regulator
DMB86_RS03380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DMB86_RS03400	COG1175	transmembrane transport
DMB86_RS03405	COG0395	ABC-type sugar transport system, permease component
DMB86_RS03410	COG4948	Mandelate Racemase Muconate Lactonizing
DMB86_RS03415	COG0800	Aldolase
DMB86_RS03425	COG4565	transcriptional regulatory protein
DMB86_RS03430	COG3290	protein histidine kinase activity
DMB86_RS03450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DMB86_RS03455	COG1435	thymidine kinase activity
DMB86_RS03485	COG2721	sulfolactate sulfo-lyase activity
DMB86_RS03490	COG4948	Mandelate Racemase Muconate Lactonizing
DMB86_RS03495	COG1904	glucuronate isomerase
DMB86_RS03510	COG3842	ATPase activity
DMB86_RS03520	COG0395	ABC-type sugar transport system, permease component
DMB86_RS03525	COG0246	Mannitol dehydrogenase
DMB86_RS03575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DMB86_RS03580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DMB86_RS03595	COG1832	CoA-binding protein
DMB86_RS03600	COG0726	polysaccharide deacetylase
DMB86_RS03630	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DMB86_RS03635	COG0047	phosphoribosylformylglycinamidine synthase activity
DMB86_RS03640	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DMB86_RS03655	COG1846	Transcriptional regulator
DMB86_RS03675	COG1131	(ABC) transporter
DMB86_RS03685	COG0129	dihydroxy-acid dehydratase activity
DMB86_RS03695	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DMB86_RS03725	COG0386	Belongs to the glutathione peroxidase family
DMB86_RS03745	COG1309	transcriptional regulator
DMB86_RS03770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DMB86_RS03775	COG0531	amino acid
DMB86_RS03780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DMB86_RS03810	COG4942	peptidase
DMB86_RS03825	COG0277	FAD linked oxidase domain protein
DMB86_RS03870	COG3842	ATPase activity
DMB86_RS03880	COG3290	protein histidine kinase activity
DMB86_RS03895	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DMB86_RS03910	COG0488	(ABC) transporter
DMB86_RS03920	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DMB86_RS03925	COG2390	Transcriptional regulator
DMB86_RS03935	COG1132	(ABC) transporter
DMB86_RS03950	COG0523	cobalamin synthesis protein
DMB86_RS03955	COG0402	S-adenosylhomocysteine deaminase activity
DMB86_RS03960	COG2814	Major facilitator Superfamily
DMB86_RS03965	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DMB86_RS04000	COG0484	heat shock protein binding
DMB86_RS04010	COG0531	amino acid
DMB86_RS04020	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DMB86_RS04040	COG2314	TM2 domain
DMB86_RS04065	COG0673	inositol 2-dehydrogenase activity
DMB86_RS04080	COG1609	Transcriptional regulator
DMB86_RS04090	COG1175	transmembrane transport
DMB86_RS04095	COG0395	ABC-type sugar transport system, permease component
DMB86_RS04110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DMB86_RS04125	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS04150	COG0477	Major facilitator Superfamily
DMB86_RS04165	COG0667	Aldo Keto reductase
DMB86_RS04185	COG3971	2-oxopent-4-enoate hydratase activity
DMB86_RS04195	COG1012	belongs to the aldehyde dehydrogenase family
DMB86_RS04200	COG1802	Transcriptional regulator
DMB86_RS04225	COG4977	sequence-specific DNA binding
DMB86_RS04230	COG3226	Transcriptional regulator
DMB86_RS04260	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
DMB86_RS04280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DMB86_RS04290	COG0604	alcohol dehydrogenase
DMB86_RS04300	COG3483	tryptophan 2,3-dioxygenase activity
DMB86_RS04325	COG2814	Major facilitator Superfamily
DMB86_RS04335	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS04365	COG0343	queuine tRNA-ribosyltransferase activity
DMB86_RS04410	COG1960	acyl-CoA dehydrogenase activity
DMB86_RS04420	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DMB86_RS04430	COG0564	pseudouridine synthase activity
DMB86_RS04435	COG2223	nitrite transmembrane transporter activity
DMB86_RS04440	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DMB86_RS04445	COG1201	RNA secondary structure unwinding
DMB86_RS04465	COG1414	Transcriptional regulator
DMB86_RS04505	COG2205	protein histidine kinase activity
DMB86_RS04510	COG0745	RESPONSE REGULATOR receiver
DMB86_RS04535	COG0590	tRNA wobble adenosine to inosine editing
DMB86_RS04540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DMB86_RS04565	COG2062	phosphohistidine phosphatase, SixA
DMB86_RS04575	COG1511	domain protein
DMB86_RS04585	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DMB86_RS04590	COG1940	carbohydrate kinase activity
DMB86_RS04600	COG4608	Belongs to the ABC transporter superfamily
DMB86_RS04605	COG0444	Belongs to the ABC transporter superfamily
DMB86_RS04615	COG0747	negative chemotaxis
DMB86_RS04620	COG2186	Transcriptional regulator
DMB86_RS04630	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DMB86_RS04635	COG1017	nitric oxide dioxygenase activity
DMB86_RS04635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DMB86_RS04640	COG1959	2 iron, 2 sulfur cluster binding
DMB86_RS04655	COG0514	ATP-dependent DNA helicase (RecQ)
DMB86_RS04660	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS04670	COG4948	Mandelate Racemase Muconate Lactonizing
DMB86_RS04700	COG2186	Transcriptional regulator
DMB86_RS04720	COG1505	serine-type exopeptidase activity
DMB86_RS04735	COG1960	acyl-CoA dehydrogenase activity
DMB86_RS04740	COG0045	succinate-CoA ligase (ADP-forming) activity
DMB86_RS04745	COG1309	transcriptional regulator
DMB86_RS04765	COG1012	belongs to the aldehyde dehydrogenase family
DMB86_RS04770	COG0477	Major facilitator Superfamily
DMB86_RS04775	COG2030	dehydratase
DMB86_RS04785	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DMB86_RS04800	COG0604	alcohol dehydrogenase
DMB86_RS04800	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS04800	COG3321	synthase
DMB86_RS04810	COG1136	(ABC) transporter
DMB86_RS04810	COG0577	efflux transmembrane transporter activity
DMB86_RS04850	COG3842	ATPase activity
DMB86_RS04860	COG0477	Major facilitator Superfamily
DMB86_RS04875	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DMB86_RS04880	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DMB86_RS04900	COG0588	phosphoglycerate mutase activity
DMB86_RS04905	COG0704	Plays a role in the regulation of phosphate uptake
DMB86_RS04910	COG5002	protein histidine kinase activity
DMB86_RS04930	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DMB86_RS04935	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DMB86_RS04940	COG0215	cysteine-tRNA ligase activity
DMB86_RS04945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DMB86_RS04960	COG0366	Alpha amylase catalytic
DMB86_RS04965	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DMB86_RS05010	COG4974	Belongs to the 'phage' integrase family
DMB86_RS05015	COG0582	viral genome integration into host DNA
DMB86_RS05020	COG4974	Belongs to the 'phage' integrase family
DMB86_RS05055	COG3842	ATPase activity
DMB86_RS05080	COG0582	viral genome integration into host DNA
DMB86_RS05090	COG1484	DNA-dependent DNA replication
DMB86_RS05105	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DMB86_RS05110	COG2390	Transcriptional regulator
DMB86_RS05110	COG4584	PFAM Integrase catalytic
DMB86_RS05170	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DMB86_RS05180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DMB86_RS05185	COG4279	zinc finger
DMB86_RS05190	COG1473	amidohydrolase
DMB86_RS05205	COG2130	NADP-dependent
DMB86_RS05220	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS05235	COG1012	belongs to the aldehyde dehydrogenase family
DMB86_RS05250	COG1136	(ABC) transporter
DMB86_RS05255	COG0577	efflux transmembrane transporter activity
DMB86_RS05275	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DMB86_RS05295	COG0459	protein refolding
DMB86_RS05300	COG0328	RNA-DNA hybrid ribonuclease activity
DMB86_RS05310	COG2205	protein histidine kinase activity
DMB86_RS05315	COG0745	RESPONSE REGULATOR receiver
DMB86_RS05330	COG3119	arylsulfatase activity
DMB86_RS05335	COG0395	ABC-type sugar transport system, permease component
DMB86_RS05340	COG1175	transmembrane transport
DMB86_RS05350	COG1609	Transcriptional regulator
DMB86_RS05355	COG0673	inositol 2-dehydrogenase activity
DMB86_RS05365	COG5492	domain, Protein
DMB86_RS05385	COG3119	arylsulfatase activity
DMB86_RS05395	COG3119	arylsulfatase activity
DMB86_RS05400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DMB86_RS05405	COG1061	Type III restriction enzyme res subunit
DMB86_RS05420	COG1278	Cold shock
DMB86_RS05445	COG0739	heme binding
DMB86_RS05450	COG1388	LysM domain
DMB86_RS05450	COG3103	Sh3 type 3 domain protein
DMB86_RS05450	COG0791	NLP P60 protein
DMB86_RS05455	COG0746	molybdenum cofactor guanylyltransferase activity
DMB86_RS05480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DMB86_RS05485	COG1126	abc transporter atp-binding protein
DMB86_RS05490	COG0765	amino acid transport
DMB86_RS05495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DMB86_RS05500	COG1132	(ABC) transporter
DMB86_RS05520	COG2962	Rard protein
DMB86_RS05535	COG0483	inositol monophosphate 1-phosphatase activity
DMB86_RS05545	COG0045	succinate-CoA ligase (ADP-forming) activity
DMB86_RS05555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DMB86_RS05565	COG1414	Transcriptional regulator
DMB86_RS05575	COG0477	Major facilitator Superfamily
DMB86_RS05605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DMB86_RS05630	COG1760	l-serine dehydratase
DMB86_RS05655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DMB86_RS05660	COG0022	dehydrogenase e1 component
DMB86_RS05680	COG1396	sequence-specific DNA binding
DMB86_RS05700	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DMB86_RS05725	COG0028	Belongs to the TPP enzyme family
DMB86_RS05755	COG1090	epimerase
DMB86_RS05770	COG2186	Transcriptional regulator
DMB86_RS05780	COG1027	Aspartate ammonia-lyase
DMB86_RS05790	COG2188	Transcriptional regulator
DMB86_RS05800	COG1126	abc transporter atp-binding protein
DMB86_RS05805	COG0765	amino acid transport
DMB86_RS05810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DMB86_RS05815	COG0251	oxidation-reduction process
DMB86_RS05820	COG0431	NADPH-dependent FMN reductase
DMB86_RS05840	COG2376	Dihydroxyacetone kinase
DMB86_RS05845	COG0698	ribose 5-phosphate isomerase
DMB86_RS05850	COG1250	3-hydroxyacyl-CoA dehydrogenase
DMB86_RS05855	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS05860	COG2271	Major facilitator Superfamily
DMB86_RS05865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DMB86_RS05870	COG2271	Major facilitator Superfamily
DMB86_RS05875	COG0149	triose-phosphate isomerase activity
DMB86_RS05880	COG2084	Dehydrogenase
DMB86_RS05925	COG1185	polyribonucleotide nucleotidyltransferase activity
DMB86_RS05930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DMB86_RS05950	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DMB86_RS05955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DMB86_RS05980	COG2161	toxin-antitoxin pair type II binding
DMB86_RS05985	COG4115	mRNA cleavage
DMB86_RS06025	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DMB86_RS06075	COG2205	protein histidine kinase activity
DMB86_RS06080	COG0745	RESPONSE REGULATOR receiver
DMB86_RS06085	COG0477	Major facilitator Superfamily
DMB86_RS06090	COG2188	Transcriptional regulator
DMB86_RS06135	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DMB86_RS06150	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DMB86_RS06175	COG1960	acyl-CoA dehydrogenase activity
DMB86_RS06220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DMB86_RS06225	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DMB86_RS06250	COG1472	Belongs to the glycosyl hydrolase 3 family
DMB86_RS06255	COG0138	bifunctional purine biosynthesis protein purh
DMB86_RS06270	COG2838	Isocitrate dehydrogenase
DMB86_RS06275	COG0683	leucine binding
DMB86_RS06305	COG4213	ABC transporter substrate-binding protein
DMB86_RS06340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DMB86_RS06345	COG0531	amino acid
DMB86_RS06375	COG4770	biotin carboxylase activity
DMB86_RS06380	COG1984	allophanate hydrolase subunit 2
DMB86_RS06385	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DMB86_RS06400	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DMB86_RS06405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DMB86_RS06430	COG0180	Tryptophanyl-tRNA synthetase
DMB86_RS06445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DMB86_RS06460	COG2009	succinate dehydrogenase
DMB86_RS06465	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DMB86_RS06465	COG0662	Cupin 2, conserved barrel domain protein
DMB86_RS06470	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DMB86_RS06470	COG1473	amidohydrolase
DMB86_RS06475	COG1846	Transcriptional regulator
DMB86_RS06480	COG1764	response to oxidative stress
DMB86_RS06485	COG2130	NADP-dependent
DMB86_RS06490	COG1744	ABC transporter substrate-binding protein PnrA-like
DMB86_RS06495	COG3845	ABC transporter
DMB86_RS06500	COG4603	Belongs to the binding-protein-dependent transport system permease family
DMB86_RS06505	COG1079	Belongs to the binding-protein-dependent transport system permease family
DMB86_RS06525	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DMB86_RS06530	COG3956	TIGRFAM MazG family protein
DMB86_RS06545	COG0148	phosphopyruvate hydratase activity
DMB86_RS06590	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DMB86_RS06600	COG1349	DNA-binding transcription factor activity
DMB86_RS06605	COG2017	converts alpha-aldose to the beta-anomer
DMB86_RS06615	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DMB86_RS06620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DMB86_RS06630	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DMB86_RS06640	COG1331	Highly conserved protein containing a thioredoxin domain
DMB86_RS06650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DMB86_RS06660	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DMB86_RS06695	COG0114	fumarate hydratase activity
DMB86_RS06700	COG0288	reversible hydration of carbon dioxide
DMB86_RS06785	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DMB86_RS06790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DMB86_RS06795	COG0300	oxidoreductase activity
DMB86_RS06800	COG0277	FAD linked oxidase domain protein
DMB86_RS06865	COG0714	Associated with various cellular activities
DMB86_RS06870	COG0084	hydrolase, TatD family'
DMB86_RS06875	COG3583	domain protein
DMB86_RS06880	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DMB86_RS06885	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DMB86_RS06890	COG0488	(ABC) transporter
DMB86_RS06905	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DMB86_RS06915	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DMB86_RS06920	COG0193	aminoacyl-tRNA hydrolase activity
DMB86_RS06935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DMB86_RS06940	COG0673	inositol 2-dehydrogenase activity
DMB86_RS06945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMB86_RS06950	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DMB86_RS06960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DMB86_RS06975	COG1215	transferase activity, transferring glycosyl groups
DMB86_RS07035	COG0579	oxidoreductase
DMB86_RS07045	COG1088	dTDP-glucose 4,6-dehydratase activity
DMB86_RS07050	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DMB86_RS07060	COG0822	iron-sulfur transferase activity
DMB86_RS07095	COG5002	protein histidine kinase activity
DMB86_RS07100	COG0745	RESPONSE REGULATOR receiver
DMB86_RS07110	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DMB86_RS07155	COG1216	Glycosyl transferase, family 2
DMB86_RS07190	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DMB86_RS07195	COG2855	membrane
DMB86_RS07210	COG1648	precorrin-2 dehydrogenase activity
DMB86_RS07210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DMB86_RS07215	COG2146	nitrite reductase [NAD(P)H] activity
DMB86_RS07215	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DMB86_RS07245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DMB86_RS07260	COG5002	protein histidine kinase activity
DMB86_RS07265	COG0745	RESPONSE REGULATOR receiver
DMB86_RS07275	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DMB86_RS07280	COG0243	molybdopterin cofactor binding
DMB86_RS07285	COG2223	nitrite transmembrane transporter activity
DMB86_RS07290	COG0477	Major facilitator Superfamily
DMB86_RS07295	COG4770	biotin carboxylase activity
DMB86_RS07300	COG0424	maF-like protein
DMB86_RS07305	COG0477	Major facilitator Superfamily
DMB86_RS07310	COG1309	transcriptional regulator
DMB86_RS07340	COG2409	Drug exporters of the RND superfamily
DMB86_RS07345	COG1309	transcriptional regulator
DMB86_RS07355	COG1823	symporter activity
DMB86_RS07385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DMB86_RS07445	COG0631	protein serine/threonine phosphatase activity
DMB86_RS07495	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DMB86_RS07535	COG0456	acetyltransferase
DMB86_RS07540	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DMB86_RS07545	COG0154	amidase activity
DMB86_RS07550	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DMB86_RS07570	COG4209	transmembrane transport
DMB86_RS07575	COG0395	ABC-type sugar transport system, permease component
DMB86_RS07585	COG1609	Transcriptional regulator
DMB86_RS07590	COG0673	inositol 2-dehydrogenase activity
DMB86_RS07595	COG3579	cysteine-type endopeptidase activity
DMB86_RS07605	COG0583	DNA-binding transcription factor activity
DMB86_RS07610	COG1063	alcohol dehydrogenase
DMB86_RS07615	COG0156	8-amino-7-oxononanoate synthase activity
DMB86_RS07625	COG1280	lysine exporter protein (LysE YggA)
DMB86_RS07630	COG1280	lysine exporter protein (LysE YggA)
DMB86_RS07635	COG1228	amidohydrolase
DMB86_RS07640	COG0366	Alpha amylase catalytic
DMB86_RS07640	COG1470	cell adhesion involved in biofilm formation
DMB86_RS07685	COG2183	response to ionizing radiation
DMB86_RS07690	COG2873	o-acetylhomoserine
DMB86_RS07695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DMB86_RS07725	COG0423	glycine-tRNA ligase activity
DMB86_RS07750	COG3424	synthase
DMB86_RS07760	COG1131	(ABC) transporter
DMB86_RS07770	COG4585	Histidine kinase
DMB86_RS07775	COG2197	response regulator
DMB86_RS07780	COG2239	Acts as a magnesium transporter
DMB86_RS07815	COG0358	DNA primase activity
DMB86_RS07830	COG0436	Aminotransferase
DMB86_RS07855	COG0297	glycogen (starch) synthase activity
DMB86_RS07860	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DMB86_RS07860	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DMB86_RS07865	COG2814	Major facilitator Superfamily
DMB86_RS07885	COG0438	transferase activity, transferring glycosyl groups
DMB86_RS07900	COG4974	Belongs to the 'phage' integrase family
DMB86_RS07990	COG0052	Belongs to the universal ribosomal protein uS2 family
DMB86_RS07995	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DMB86_RS08000	COG0528	UMP kinase activity
DMB86_RS08005	COG0233	cytoplasmic translational termination
DMB86_RS08090	COG2161	toxin-antitoxin pair type II binding
DMB86_RS08140	COG1131	(ABC) transporter
DMB86_RS08150	COG1522	sequence-specific DNA binding
DMB86_RS08160	COG0022	dehydrogenase e1 component
DMB86_RS08165	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMB86_RS08175	COG1309	transcriptional regulator
DMB86_RS08180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DMB86_RS08190	COG1960	acyl-CoA dehydrogenase activity
DMB86_RS08215	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DMB86_RS08220	COG0750	zinc metalloprotease
DMB86_RS08240	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DMB86_RS08255	COG1902	pentaerythritol trinitrate reductase activity
DMB86_RS08255	COG0446	pyridine nucleotide-disulphide oxidoreductase
DMB86_RS08265	COG1309	transcriptional regulator
DMB86_RS08275	COG1131	(ABC) transporter
DMB86_RS08280	COG0442	prolyl-tRNA aminoacylation
DMB86_RS08305	COG0779	Required for maturation of 30S ribosomal subunits
DMB86_RS08320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DMB86_RS08325	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DMB86_RS08335	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DMB86_RS08355	COG0196	riboflavin kinase activity
DMB86_RS08360	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DMB86_RS08365	COG1185	polyribonucleotide nucleotidyltransferase activity
DMB86_RS08370	COG0612	Peptidase, M16
DMB86_RS08375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DMB86_RS08405	COG0315	cyclic pyranopterin monophosphate synthase activity
DMB86_RS08410	COG0521	Mo-molybdopterin cofactor biosynthetic process
DMB86_RS08420	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DMB86_RS08430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DMB86_RS08435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DMB86_RS08440	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DMB86_RS08445	COG1674	ftsk spoiiie
DMB86_RS08455	COG1546	Belongs to the CinA family
DMB86_RS08455	COG1058	Belongs to the CinA family
DMB86_RS08460	COG1396	sequence-specific DNA binding
DMB86_RS08475	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DMB86_RS08480	COG2137	regulation of response to DNA damage stimulus
DMB86_RS08490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DMB86_RS08495	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DMB86_RS08500	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DMB86_RS08505	COG2813	Specifically methylates the guanine in position
DMB86_RS08510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DMB86_RS08520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DMB86_RS08530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DMB86_RS08535	COG0131	Imidazoleglycerol-phosphate dehydratase
DMB86_RS08540	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DMB86_RS08545	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DMB86_RS08565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DMB86_RS08570	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DMB86_RS08575	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DMB86_RS08580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DMB86_RS08590	COG2814	Major facilitator Superfamily
DMB86_RS08595	COG0494	nUDIX hydrolase
DMB86_RS08610	COG0318	PFAM AMP-dependent synthetase and ligase
DMB86_RS08630	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DMB86_RS08635	COG0072	phenylalanine-tRNA ligase activity
DMB86_RS08635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DMB86_RS08670	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DMB86_RS08675	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DMB86_RS08680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DMB86_RS08685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DMB86_RS08690	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DMB86_RS08695	COG1438	arginine binding
DMB86_RS08700	COG0137	argininosuccinate synthase activity
DMB86_RS08705	COG0165	Argininosuccinate lyase
DMB86_RS08740	COG2094	Belongs to the DNA glycosylase MPG family
DMB86_RS08750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DMB86_RS08795	COG0647	UMP catabolic process
DMB86_RS08810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DMB86_RS08815	COG0497	DNA recombination
DMB86_RS08820	COG0504	CTP synthase activity
DMB86_RS08855	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DMB86_RS08860	COG2079	MmgE PrpD family protein
DMB86_RS08880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DMB86_RS08895	COG3290	protein histidine kinase activity
DMB86_RS08900	COG1301	dicarboxylic acid transport
DMB86_RS08920	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DMB86_RS08925	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DMB86_RS08940	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DMB86_RS08950	COG1160	GTP binding
DMB86_RS08970	COG1233	COG1233 Phytoene dehydrogenase and related
DMB86_RS08975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DMB86_RS08980	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DMB86_RS08995	COG0509	glycine decarboxylation via glycine cleavage system
DMB86_RS09000	COG1716	ATPase activity
DMB86_RS09030	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DMB86_RS09030	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DMB86_RS09035	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DMB86_RS09045	COG1022	Amp-dependent synthetase and ligase
DMB86_RS09050	COG1940	carbohydrate kinase activity
DMB86_RS09070	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DMB86_RS09100	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DMB86_RS09115	COG1484	DNA-dependent DNA replication
DMB86_RS09120	COG0515	serine threonine protein kinase
DMB86_RS09120	COG2815	serine threonine protein kinase
DMB86_RS09125	COG1388	LysM domain
DMB86_RS09125	COG3942	CHAP domain
DMB86_RS09135	COG0142	geranyltranstransferase activity
DMB86_RS09150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DMB86_RS09160	COG2001	Belongs to the MraZ family
DMB86_RS09165	COG0275	rRNA processing
DMB86_RS09175	COG0768	penicillin binding
DMB86_RS09180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DMB86_RS09190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DMB86_RS09195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DMB86_RS09205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DMB86_RS09210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DMB86_RS09215	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DMB86_RS09220	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DMB86_RS09230	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DMB86_RS09235	COG1799	cell septum assembly
DMB86_RS09245	COG3599	regulation of cell shape
DMB86_RS09250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DMB86_RS09260	COG0587	DNA-directed DNA polymerase activity
DMB86_RS09270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DMB86_RS09275	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DMB86_RS09300	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DMB86_RS09305	COG0174	glutamine synthetase
DMB86_RS09310	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DMB86_RS09325	COG0765	amino acid transport
DMB86_RS09330	COG1126	abc transporter atp-binding protein
DMB86_RS09335	COG2066	Belongs to the glutaminase family
DMB86_RS09360	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DMB86_RS09365	COG0321	lipoyl(octanoyl) transferase activity
DMB86_RS09370	COG0515	serine threonine protein kinase
DMB86_RS09375	COG0793	Belongs to the peptidase S41A family
DMB86_RS09375	COG4946	Tricorn protease homolog
DMB86_RS09385	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMB86_RS09390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DMB86_RS09395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DMB86_RS09420	COG1672	PFAM Archaeal ATPase
DMB86_RS09420	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DMB86_RS09445	COG1271	oxidase subunit
DMB86_RS09450	COG1294	oxidase, subunit
DMB86_RS09455	COG4988	ABC transporter
DMB86_RS09475	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DMB86_RS09510	COG0756	dUTP diphosphatase activity
DMB86_RS09535	COG0569	domain protein
DMB86_RS09540	COG0531	amino acid
DMB86_RS09545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DMB86_RS09555	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DMB86_RS09560	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DMB86_RS09565	COG3557	Belongs to the UPF0374 family
DMB86_RS09575	COG0667	Aldo Keto reductase
DMB86_RS09580	COG2814	Major facilitator Superfamily
DMB86_RS09585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DMB86_RS09600	COG0318	PFAM AMP-dependent synthetase and ligase
DMB86_RS09620	COG1250	3-hydroxyacyl-CoA dehydrogenase
DMB86_RS09620	COG1024	Enoyl-CoA hydratase
DMB86_RS09625	COG0183	Belongs to the thiolase family
DMB86_RS09630	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DMB86_RS09655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DMB86_RS09695	COG2409	Drug exporters of the RND superfamily
DMB86_RS09750	COG0242	peptide deformylase activity
DMB86_RS09755	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DMB86_RS09765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DMB86_RS09785	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DMB86_RS09785	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DMB86_RS09790	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DMB86_RS09790	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DMB86_RS09795	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DMB86_RS09800	COG0140	phosphoribosyl-ATP diphosphatase activity
DMB86_RS09805	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DMB86_RS09810	COG0107	imidazoleglycerol-phosphate synthase activity
DMB86_RS09820	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DMB86_RS09840	COG0134	indole-3-glycerol-phosphate synthase activity
DMB86_RS09845	COG0133	tryptophan synthase activity
DMB86_RS09850	COG0159	tryptophan synthase activity
DMB86_RS09855	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DMB86_RS09860	COG0070	glutamate synthase
DMB86_RS09860	COG0069	glutamate synthase activity
DMB86_RS09860	COG0067	glutamate synthase
DMB86_RS09920	COG1609	Transcriptional regulator
DMB86_RS09925	COG1129	ABC transporter
DMB86_RS09930	COG1172	Belongs to the binding-protein-dependent transport system permease family
DMB86_RS09945	COG3254	rhamnose metabolic process
DMB86_RS09955	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS09955	COG3347	Dehydrogenase
DMB86_RS09960	COG1070	Carbohydrate kinase
DMB86_RS09970	COG0673	inositol 2-dehydrogenase activity
DMB86_RS09980	COG1609	Transcriptional regulator
DMB86_RS09985	COG0673	inositol 2-dehydrogenase activity
DMB86_RS10005	COG2135	peptidase activity
DMB86_RS10010	COG2261	transglycosylase associated protein
DMB86_RS10040	COG0071	Belongs to the small heat shock protein (HSP20) family
DMB86_RS10090	COG2080	2 iron, 2 sulfur cluster binding
DMB86_RS10095	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DMB86_RS10100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DMB86_RS10140	COG3237	CsbD-like
DMB86_RS10185	COG3547	Transposase (IS116 IS110 IS902 family)
DMB86_RS10205	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DMB86_RS10220	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DMB86_RS10240	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS10255	COG3387	PFAM Glycoside hydrolase 15-related
DMB86_RS10265	COG4948	Mandelate Racemase Muconate Lactonizing
DMB86_RS10270	COG0028	Belongs to the TPP enzyme family
DMB86_RS10295	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS10300	COG0477	Major facilitator Superfamily
DMB86_RS10310	COG0693	protein deglycase activity
DMB86_RS10315	COG0477	Major facilitator Superfamily
DMB86_RS10335	COG0667	Aldo Keto reductase
DMB86_RS10360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DMB86_RS10375	COG1832	CoA-binding protein
DMB86_RS10425	COG1140	nitrate reductase beta subunit
DMB86_RS10450	COG1414	Transcriptional regulator
DMB86_RS10455	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DMB86_RS10465	COG0183	Belongs to the thiolase family
DMB86_RS10470	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DMB86_RS10480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DMB86_RS10485	COG3485	protocatechuate 3,4-dioxygenase
DMB86_RS10490	COG3485	protocatechuate 3,4-dioxygenase
DMB86_RS10495	COG1082	Xylose isomerase domain protein TIM barrel
DMB86_RS10495	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DMB86_RS10500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DMB86_RS10510	COG0477	Major facilitator Superfamily
DMB86_RS10520	COG0667	Aldo Keto reductase
DMB86_RS10605	COG1550	Protein conserved in bacteria
DMB86_RS10625	COG0657	acetylesterase activity
DMB86_RS10640	COG1902	pentaerythritol trinitrate reductase activity
DMB86_RS10645	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DMB86_RS10700	COG1643	Atp-dependent helicase
DMB86_RS10705	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS10710	COG0783	Belongs to the Dps family
DMB86_RS10725	COG0009	L-threonylcarbamoyladenylate synthase
DMB86_RS10730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DMB86_RS10745	COG0477	Major facilitator Superfamily
DMB86_RS10755	COG0832	Belongs to the urease beta subunit family
DMB86_RS10760	COG0804	urea catabolic process
DMB86_RS10765	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DMB86_RS10770	COG0830	nickel cation binding
DMB86_RS10775	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DMB86_RS10780	COG0829	nickel cation binding
DMB86_RS10785	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DMB86_RS10790	COG0109	protoheme IX farnesyltransferase activity
DMB86_RS10810	COG0673	inositol 2-dehydrogenase activity
DMB86_RS10855	COG0436	Aminotransferase
DMB86_RS10860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DMB86_RS10885	COG2050	protein possibly involved in aromatic compounds catabolism
DMB86_RS10895	COG4552	Acetyltransferase involved in intracellular survival and related
DMB86_RS10900	COG2146	nitrite reductase [NAD(P)H] activity
DMB86_RS10900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DMB86_RS10910	COG0539	negative regulation of cytoplasmic translation
DMB86_RS10915	COG1739	Uncharacterized protein family UPF0029
DMB86_RS10920	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DMB86_RS10920	COG1672	PFAM Archaeal ATPase
DMB86_RS10930	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DMB86_RS10930	COG0237	dephospho-CoA kinase activity
DMB86_RS10935	COG0556	nucleotide-excision repair
DMB86_RS10965	COG4106	trans-aconitate 2-methyltransferase activity
DMB86_RS11005	COG0322	excinuclease ABC activity
DMB86_RS11010	COG1660	Displays ATPase and GTPase activities
DMB86_RS11020	COG1481	regulation of sporulation
DMB86_RS11030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DMB86_RS11035	COG0126	phosphoglycerate kinase activity
DMB86_RS11040	COG0149	triose-phosphate isomerase activity
DMB86_RS11045	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DMB86_RS11050	COG0363	glucosamine-6-phosphate deaminase activity
DMB86_RS11065	COG0166	Belongs to the GPI family
DMB86_RS11070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DMB86_RS11080	COG0109	protoheme IX farnesyltransferase activity
DMB86_RS11120	COG0396	ATPase activity
DMB86_RS11125	COG2151	metal-sulfur cluster biosynthetic enzyme
DMB86_RS11130	COG0318	PFAM AMP-dependent synthetase and ligase
DMB86_RS11135	COG0183	Belongs to the thiolase family
DMB86_RS11150	COG1122	ATPase activity
DMB86_RS11155	COG1268	BioY protein
DMB86_RS11160	COG0488	(ABC) transporter
DMB86_RS11185	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS11190	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS11195	COG0560	Phosphoserine phosphatase
DMB86_RS11195	COG3830	Belongs to the UPF0237 family
DMB86_RS11200	COG1119	ATPase activity
DMB86_RS11215	COG0254	rRNA binding
DMB86_RS11235	COG2855	membrane
DMB86_RS11245	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DMB86_RS11250	COG0297	glycogen (starch) synthase activity
DMB86_RS11265	COG0183	Belongs to the thiolase family
DMB86_RS11270	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS11325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DMB86_RS11345	COG0656	L-ascorbic acid biosynthetic process
DMB86_RS11350	COG1968	undecaprenyl-diphosphatase activity
DMB86_RS11355	COG0215	cysteine-tRNA ligase activity
DMB86_RS11365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DMB86_RS11370	COG0517	IMP dehydrogenase activity
DMB86_RS11370	COG1994	Peptidase M50
DMB86_RS11380	COG1222	aaa ATPase
DMB86_RS11385	COG4122	O-methyltransferase activity
DMB86_RS11395	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DMB86_RS11400	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DMB86_RS11405	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DMB86_RS11420	COG2378	regulation of single-species biofilm formation
DMB86_RS11430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DMB86_RS11435	COG0805	protein transport
DMB86_RS11445	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DMB86_RS11450	COG1216	Glycosyl transferase, family 2
DMB86_RS11480	COG2226	methyltransferase
DMB86_RS11485	COG0242	peptide deformylase activity
DMB86_RS11495	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DMB86_RS11525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DMB86_RS11535	COG1063	alcohol dehydrogenase
DMB86_RS11565	COG4133	protoheme IX ABC transporter activity
DMB86_RS11585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DMB86_RS11590	COG1845	cytochrome c oxidase, subunit III
DMB86_RS11595	COG2010	Cytochrome c
DMB86_RS11600	COG0723	plastoquinol--plastocyanin reductase activity
DMB86_RS11605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DMB86_RS11610	COG2188	Transcriptional regulator
DMB86_RS11625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DMB86_RS11630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DMB86_RS11650	COG0667	Aldo Keto reductase
DMB86_RS11655	COG0167	dihydroorotate dehydrogenase activity
DMB86_RS11675	COG4644	lycopene metabolic process
DMB86_RS11680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DMB86_RS11685	COG1381	Involved in DNA repair and RecF pathway recombination
DMB86_RS11690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DMB86_RS11695	COG3590	peptidase
DMB86_RS11700	COG1316	TRANSCRIPTIONal
DMB86_RS11705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DMB86_RS11715	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DMB86_RS11735	COG0484	heat shock protein binding
DMB86_RS11740	COG1420	regulation of RNA biosynthetic process
DMB86_RS11755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DMB86_RS11760	COG0481	GTPase activity
DMB86_RS11770	COG0268	Binds directly to 16S ribosomal RNA
DMB86_RS11785	COG1555	photosystem II stabilization
DMB86_RS11785	COG1596	polysaccharide export
DMB86_RS11790	COG1307	EDD domain protein, DegV family
DMB86_RS11795	COG0495	leucyl-tRNA aminoacylation
DMB86_RS11800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DMB86_RS11805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DMB86_RS11810	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DMB86_RS11815	COG2390	Transcriptional regulator
DMB86_RS11825	COG0596	Alpha beta hydrolase
DMB86_RS11840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DMB86_RS11845	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DMB86_RS11855	COG1758	RNA polymerase activity
DMB86_RS11860	COG0194	GDP metabolic process
DMB86_RS11865	COG0194	GDP metabolic process
DMB86_RS11870	COG0284	orotidine-5'-phosphate decarboxylase activity
DMB86_RS11875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DMB86_RS11880	COG0505	Belongs to the CarA family
DMB86_RS11890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DMB86_RS11895	COG0540	Belongs to the ATCase OTCase family
DMB86_RS11900	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DMB86_RS11910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DMB86_RS11915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DMB86_RS11925	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DMB86_RS11930	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DMB86_RS11935	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DMB86_RS11940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DMB86_RS11950	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DMB86_RS11955	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DMB86_RS11970	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DMB86_RS11995	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DMB86_RS12000	COG0124	histidyl-tRNA synthetase
DMB86_RS12010	COG1196	nuclear chromosome segregation
DMB86_RS12020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DMB86_RS12025	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMB86_RS12040	COG2255	four-way junction helicase activity
DMB86_RS12045	COG0632	four-way junction helicase activity
DMB86_RS12050	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DMB86_RS12055	COG0217	transcriptional regulatory protein
DMB86_RS12060	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DMB86_RS12065	COG0367	asparagine synthase
DMB86_RS12070	COG0339	signal peptide processing
DMB86_RS12080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DMB86_RS12085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DMB86_RS12095	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DMB86_RS12100	COG0587	DNA-directed DNA polymerase activity
DMB86_RS12110	COG0456	acetyltransferase
DMB86_RS12130	COG2135	peptidase activity
DMB86_RS12170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DMB86_RS12175	COG0318	PFAM AMP-dependent synthetase and ligase
DMB86_RS12185	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DMB86_RS12190	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DMB86_RS12195	COG1780	Probably involved in ribonucleotide reductase function
DMB86_RS12210	COG1012	belongs to the aldehyde dehydrogenase family
DMB86_RS12220	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DMB86_RS12235	COG1940	carbohydrate kinase activity
DMB86_RS12240	COG2813	Specifically methylates the guanine in position
DMB86_RS12245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DMB86_RS12250	COG3012	SEC-C Motif Domain Protein
DMB86_RS12270	COG0799	negative regulation of ribosome biogenesis
DMB86_RS12280	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DMB86_RS12290	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DMB86_RS12295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DMB86_RS12300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DMB86_RS12305	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DMB86_RS12310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DMB86_RS12315	COG0351	phosphomethylpyrimidine kinase
DMB86_RS12315	COG0352	thiamine-phosphate diphosphorylase activity
DMB86_RS12315	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DMB86_RS12320	COG1530	ribonuclease E activity
DMB86_RS12330	COG0105	UTP biosynthetic process
DMB86_RS12345	COG0285	dihydrofolate synthase activity
DMB86_RS12350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DMB86_RS12365	COG0525	valine-tRNA ligase activity
DMB86_RS12370	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DMB86_RS12375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DMB86_RS12380	COG0740	serine-type endopeptidase activity
DMB86_RS12385	COG0740	serine-type endopeptidase activity
DMB86_RS12390	COG0544	peptidyl-prolyl cis-trans isomerase activity
DMB86_RS12410	COG0698	ribose 5-phosphate isomerase
DMB86_RS12435	COG0668	transmembrane transport
DMB86_RS12455	COG1946	Acyl-CoA thioesterase
DMB86_RS12470	COG0629	single-stranded DNA binding
DMB86_RS12490	COG1401	restriction endodeoxyribonuclease activity
DMB86_RS12495	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DMB86_RS12500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DMB86_RS12505	COG1111	helicase
DMB86_RS12505	COG1205	dead DEAH box helicase
DMB86_RS12530	COG0587	DNA-directed DNA polymerase activity
DMB86_RS12545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DMB86_RS12600	COG1388	LysM domain
DMB86_RS12600	COG0791	NLP P60 protein
DMB86_RS12600	COG3103	Sh3 type 3 domain protein
DMB86_RS12655	COG0302	gtp cyclohydrolase
DMB86_RS12710	COG0395	ABC-type sugar transport system, permease component
DMB86_RS12760	COG0346	lactoylglutathione lyase activity
DMB86_RS12770	COG0640	Transcriptional regulator
DMB86_RS12790	COG0582	viral genome integration into host DNA
DMB86_RS12805	COG2814	Major facilitator Superfamily
DMB86_RS12820	COG1902	pentaerythritol trinitrate reductase activity
DMB86_RS12835	COG1309	transcriptional regulator
DMB86_RS12840	COG0596	Alpha beta hydrolase
DMB86_RS12845	COG0604	alcohol dehydrogenase
DMB86_RS12845	COG3321	synthase
DMB86_RS12850	COG2267	carboxylic ester hydrolase activity
DMB86_RS12865	COG1027	Aspartate ammonia-lyase
DMB86_RS12875	COG0473	3-isopropylmalate dehydrogenase activity
DMB86_RS12880	COG1012	belongs to the aldehyde dehydrogenase family
DMB86_RS12885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DMB86_RS12895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DMB86_RS12900	COG0765	amino acid transport
DMB86_RS12905	COG1126	abc transporter atp-binding protein
DMB86_RS12915	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DMB86_RS12940	COG1609	Transcriptional regulator
DMB86_RS12955	COG0395	ABC-type sugar transport system, permease component
DMB86_RS12965	COG1621	beta-fructofuranosidase activity
DMB86_RS12995	COG1609	Transcriptional regulator
DMB86_RS13005	COG0800	Aldolase
DMB86_RS13040	COG2222	sugar isomerase
DMB86_RS13045	COG1940	carbohydrate kinase activity
DMB86_RS13065	COG1349	DNA-binding transcription factor activity
DMB86_RS13075	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DMB86_RS13080	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DMB86_RS13085	COG1012	belongs to the aldehyde dehydrogenase family
DMB86_RS13120	COG1027	Aspartate ammonia-lyase
DMB86_RS13160	COG2801	Transposase and inactivated derivatives
DMB86_RS13170	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DMB86_RS13200	COG0477	Major facilitator Superfamily
DMB86_RS13205	COG3119	arylsulfatase activity
DMB86_RS13215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DMB86_RS13265	COG0477	Major facilitator Superfamily
DMB86_RS13270	COG1940	carbohydrate kinase activity
DMB86_RS13320	COG1228	amidohydrolase
DMB86_RS13325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DMB86_RS13335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DMB86_RS13370	COG0583	DNA-binding transcription factor activity
DMB86_RS13385	COG2271	Major facilitator Superfamily
DMB86_RS13395	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DMB86_RS13425	COG1131	(ABC) transporter
DMB86_RS13440	COG0702	epimerase
DMB86_RS13445	COG0765	amino acid transport
DMB86_RS13450	COG0765	amino acid transport
DMB86_RS13460	COG1126	abc transporter atp-binding protein
DMB86_RS13470	COG3290	protein histidine kinase activity
DMB86_RS13475	COG4565	transcriptional regulatory protein
DMB86_RS13510	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DMB86_RS13515	COG1309	transcriptional regulator
DMB86_RS13525	COG1846	Transcriptional regulator
DMB86_RS13535	COG1846	Transcriptional regulator
DMB86_RS13540	COG1846	Transcriptional regulator
DMB86_RS13585	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DMB86_RS13605	COG0798	PFAM Bile acid sodium symporter
DMB86_RS13610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DMB86_RS13640	COG3265	gluconokinase activity
DMB86_RS13645	COG3291	Pkd domain containing protein
DMB86_RS13645	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMB86_RS13650	COG0640	Transcriptional regulator
DMB86_RS13665	COG0583	DNA-binding transcription factor activity
DMB86_RS13675	COG1301	dicarboxylic acid transport
DMB86_RS13680	COG1929	Belongs to the glycerate kinase type-1 family
DMB86_RS13730	COG0531	amino acid
DMB86_RS13755	COG0542	response to heat
DMB86_RS13770	COG0640	Transcriptional regulator
DMB86_RS13775	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DMB86_RS13790	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DMB86_RS13800	COG3835	regulator
DMB86_RS13835	COG1131	(ABC) transporter
DMB86_RS13875	COG2271	Major facilitator Superfamily
DMB86_RS13880	COG0251	oxidation-reduction process
DMB86_RS13905	COG0583	DNA-binding transcription factor activity
DMB86_RS13910	COG0038	chloride channel
DMB86_RS13930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMB86_RS13935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DMB86_RS13955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DMB86_RS13970	COG3511	phospholipase C
DMB86_RS13990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DMB86_RS13995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DMB86_RS14010	COG1902	pentaerythritol trinitrate reductase activity
DMB86_RS14015	COG0789	Transcriptional regulator
DMB86_RS14050	COG1064	alcohol dehydrogenase
DMB86_RS14065	COG3795	YCII-related domain
DMB86_RS14090	COG2186	Transcriptional regulator
DMB86_RS14095	COG0477	Major facilitator Superfamily
DMB86_RS14100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DMB86_RS14105	COG1024	Enoyl-CoA hydratase
DMB86_RS14120	COG0667	Aldo Keto reductase
DMB86_RS14135	COG0698	ribose 5-phosphate isomerase
DMB86_RS14140	COG2376	Dihydroxyacetone kinase
DMB86_RS14145	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS14155	COG0477	Major facilitator Superfamily
DMB86_RS14160	COG3959	Transketolase, thiamine diphosphate binding domain
DMB86_RS14165	COG3958	Transketolase
DMB86_RS14185	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DMB86_RS14190	COG1695	Transcriptional regulator
DMB86_RS14200	COG3265	gluconokinase activity
DMB86_RS14210	COG2353	YceI-like domain
DMB86_RS14215	COG0492	ferredoxin-NADP+ reductase activity
DMB86_RS14240	COG0604	alcohol dehydrogenase
DMB86_RS14265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DMB86_RS14320	COG2318	DinB family
DMB86_RS14350	COG1335	isochorismatase
DMB86_RS14355	COG1960	acyl-CoA dehydrogenase activity
DMB86_RS14365	COG1309	transcriptional regulator
DMB86_RS14370	COG1960	acyl-CoA dehydrogenase activity
DMB86_RS14375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMB86_RS14400	COG2755	lipolytic protein G-D-S-L family
DMB86_RS14415	COG0640	Transcriptional regulator
DMB86_RS14425	COG0076	glutamate decarboxylase activity
DMB86_RS14430	COG2890	protein-(glutamine-N5) methyltransferase activity
DMB86_RS14480	COG0242	peptide deformylase activity
DMB86_RS14485	COG0477	Major facilitator Superfamily
DMB86_RS14495	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DMB86_RS14525	COG3022	response to hydroperoxide
DMB86_RS14555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DMB86_RS14560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DMB86_RS14570	COG1045	serine acetyltransferase
DMB86_RS14585	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DMB86_RS14590	COG1063	alcohol dehydrogenase
DMB86_RS14595	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS14600	COG2084	Dehydrogenase
DMB86_RS14610	COG0477	Major facilitator Superfamily
DMB86_RS14615	COG1414	Transcriptional regulator
DMB86_RS14650	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DMB86_RS14665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DMB86_RS14670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DMB86_RS14675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DMB86_RS14685	COG4974	Belongs to the 'phage' integrase family
DMB86_RS14695	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DMB86_RS14695	COG0758	DNA mediated transformation
DMB86_RS14705	COG0792	nuclease activity
DMB86_RS14715	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DMB86_RS14725	COG0681	Belongs to the peptidase S26 family
DMB86_RS14730	COG0335	large ribosomal subunit rRNA binding
DMB86_RS14735	COG0395	ABC-type sugar transport system, permease component
DMB86_RS14750	COG0336	Belongs to the RNA methyltransferase TrmD family
DMB86_RS14755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DMB86_RS14760	COG1837	Belongs to the UPF0109 family
DMB86_RS14765	COG0228	four-way junction DNA binding
DMB86_RS14775	COG2514	catechol 2,3-dioxygenase activity
DMB86_RS14780	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DMB86_RS14805	COG4608	Belongs to the ABC transporter superfamily
DMB86_RS14815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DMB86_RS14820	COG0601	transmembrane transport
DMB86_RS14845	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DMB86_RS14870	COG0477	Major facilitator Superfamily
DMB86_RS14880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DMB86_RS14885	COG0318	PFAM AMP-dependent synthetase and ligase
DMB86_RS14890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMB86_RS14895	COG3345	alpha-galactosidase
DMB86_RS14910	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DMB86_RS14915	COG0571	ribonuclease III activity
DMB86_RS14920	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DMB86_RS14930	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DMB86_RS14950	COG2268	Band 7 protein
DMB86_RS14960	COG0742	ribosomal rna small subunit methyltransferase
DMB86_RS14965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DMB86_RS15055	COG1222	aaa ATPase
DMB86_RS15095	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DMB86_RS15125	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DMB86_RS15135	COG0277	FAD linked oxidase domain protein
DMB86_RS15165	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DMB86_RS15180	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DMB86_RS15190	COG1134	teichoic acid transport
DMB86_RS15195	COG1682	transport, permease protein
DMB86_RS15200	COG0438	transferase activity, transferring glycosyl groups
DMB86_RS15215	COG1316	TRANSCRIPTIONal
DMB86_RS15225	COG2813	Specifically methylates the guanine in position
DMB86_RS15245	COG1181	Belongs to the D-alanine--D-alanine ligase family
DMB86_RS15250	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DMB86_RS15255	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DMB86_RS15265	COG1132	(ABC) transporter
DMB86_RS15275	COG0066	3-isopropylmalate dehydratase activity
DMB86_RS15280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DMB86_RS15285	COG1414	Transcriptional regulator
DMB86_RS15310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMB86_RS15345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DMB86_RS15360	COG1113	amino acid transport
DMB86_RS15365	COG0179	Fumarylacetoacetate (FAA) hydrolase
DMB86_RS15375	COG2116	formate transmembrane transporter activity
DMB86_RS15385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DMB86_RS15390	COG0473	3-isopropylmalate dehydrogenase activity
DMB86_RS15395	COG0415	Belongs to the DNA photolyase family
DMB86_RS15415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DMB86_RS15435	COG0702	epimerase
DMB86_RS15440	COG4585	Histidine kinase
DMB86_RS15445	COG2197	response regulator
DMB86_RS15450	COG1136	(ABC) transporter
DMB86_RS15450	COG0577	efflux transmembrane transporter activity
DMB86_RS15475	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DMB86_RS15480	COG0440	acetolactate synthase activity
DMB86_RS15495	COG0129	dihydroxy-acid dehydratase activity
DMB86_RS15520	COG0579	oxidoreductase
DMB86_RS15525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DMB86_RS15535	COG2814	Major facilitator Superfamily
DMB86_RS15555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DMB86_RS15560	COG0179	Fumarylacetoacetate (FAA) hydrolase
DMB86_RS15580	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DMB86_RS15585	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DMB86_RS15595	COG1113	amino acid transport
DMB86_RS15610	COG0135	phosphoribosylanthranilate isomerase activity
DMB86_RS15630	COG0419	ATPase involved in DNA repair
DMB86_RS15650	COG2149	membrane
DMB86_RS15675	COG0586	Pfam SNARE associated Golgi protein
DMB86_RS15685	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DMB86_RS15690	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DMB86_RS15700	COG1234	tRNA 3'-trailer cleavage
DMB86_RS15705	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DMB86_RS15715	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DMB86_RS15720	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DMB86_RS15725	COG1335	isochorismatase
DMB86_RS15730	COG2827	Endonuclease containing a URI domain
DMB86_RS15745	COG0363	glucosamine-6-phosphate deaminase activity
DMB86_RS15775	COG0628	permease
DMB86_RS15790	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DMB86_RS15795	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DMB86_RS15805	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DMB86_RS15810	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DMB86_RS15820	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DMB86_RS15825	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DMB86_RS15830	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DMB86_RS15835	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DMB86_RS15840	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DMB86_RS15845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DMB86_RS15850	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DMB86_RS15855	COG0356	it plays a direct role in the translocation of protons across the membrane
DMB86_RS15870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DMB86_RS15895	COG2890	protein-(glutamine-N5) methyltransferase activity
DMB86_RS15900	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DMB86_RS15910	COG0083	homoserine kinase activity
DMB86_RS15915	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DMB86_RS15920	COG0460	homoserine dehydrogenase
DMB86_RS15925	COG0019	diaminopimelate decarboxylase activity
DMB86_RS15930	COG0018	arginyl-trna synthetase
DMB86_RS15960	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DMB86_RS15975	COG0456	acetyltransferase
DMB86_RS15990	COG1643	Atp-dependent helicase
DMB86_RS16010	COG0537	adenosine 5'-monophosphoramidase activity
DMB86_RS16015	COG1064	alcohol dehydrogenase
DMB86_RS16030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DMB86_RS16045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DMB86_RS16050	COG3842	ATPase activity
DMB86_RS16055	COG0803	Belongs to the bacterial solute-binding protein 9 family
DMB86_RS16065	COG1253	flavin adenine dinucleotide binding
DMB86_RS16080	COG3265	gluconokinase activity
DMB86_RS16095	COG0567	Dehydrogenase, E1 component
DMB86_RS16095	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMB86_RS16130	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DMB86_RS16140	COG0483	inositol monophosphate 1-phosphatase activity
DMB86_RS16170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DMB86_RS16205	COG1472	Belongs to the glycosyl hydrolase 3 family
DMB86_RS16215	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DMB86_RS16230	COG2884	Cell division ATP-binding protein ftsE
DMB86_RS16235	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DMB86_RS16275	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DMB86_RS16285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DMB86_RS16290	COG1215	transferase activity, transferring glycosyl groups
DMB86_RS16335	COG1132	(ABC) transporter
DMB86_RS16340	COG0438	transferase activity, transferring glycosyl groups
DMB86_RS16370	COG0673	inositol 2-dehydrogenase activity
DMB86_RS16390	COG2755	lipolytic protein G-D-S-L family
DMB86_RS16390	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DMB86_RS16410	COG1216	Glycosyl transferase, family 2
DMB86_RS16425	COG1674	ftsk spoiiie
DMB86_RS16450	COG2902	Dehydrogenase
DMB86_RS16485	COG0653	protein targeting
DMB86_RS16490	COG3214	Protein conserved in bacteria
DMB86_RS16495	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DMB86_RS16500	COG1040	competence protein
DMB86_RS16505	COG5401	PFAM Sporulation and spore germination
DMB86_RS16510	COG5002	protein histidine kinase activity
DMB86_RS16515	COG0745	RESPONSE REGULATOR receiver
DMB86_RS16535	COG0714	Associated with various cellular activities
DMB86_RS16555	COG4172	Belongs to the ABC transporter superfamily
DMB86_RS16560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DMB86_RS16565	COG0601	transmembrane transport
DMB86_RS16580	COG0482	sulfurtransferase activity
DMB86_RS16605	COG0302	gtp cyclohydrolase
DMB86_RS16615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DMB86_RS16625	COG0484	heat shock protein binding
DMB86_RS16630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DMB86_RS16640	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DMB86_RS16650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMB86_RS16660	COG1842	Phage shock protein A
DMB86_RS16665	COG0656	L-ascorbic acid biosynthetic process
DMB86_RS16675	COG0667	Aldo Keto reductase
DMB86_RS16685	COG3585	molybdate ion transport
DMB86_RS16735	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DMB86_RS16740	COG2086	electron transfer activity
DMB86_RS16745	COG1846	Transcriptional regulator
DMB86_RS16750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DMB86_RS16755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DMB86_RS16760	COG1024	Enoyl-CoA hydratase
DMB86_RS16765	COG1250	3-hydroxyacyl-CoA dehydrogenase
DMB86_RS16765	COG1024	Enoyl-CoA hydratase
DMB86_RS16770	COG0183	Belongs to the thiolase family
DMB86_RS16780	COG1024	Enoyl-CoA hydratase
DMB86_RS16780	COG1250	3-hydroxyacyl-CoA dehydrogenase
DMB86_RS16795	COG1615	UPF0182 protein
DMB86_RS16800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DMB86_RS16855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DMB86_RS16860	COG0765	amino acid transport
DMB86_RS16865	COG1126	abc transporter atp-binding protein
DMB86_RS16885	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DMB86_RS16890	COG0113	porphobilinogen synthase activity
DMB86_RS16900	COG0181	hydroxymethylbilane synthase activity
DMB86_RS16905	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DMB86_RS16910	COG3253	May function as heme-dependent peroxidase
DMB86_RS16920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DMB86_RS16925	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DMB86_RS16955	COG2154	pterin-4-alpha-carbinolamine dehydratase
DMB86_RS16960	COG2022	thiamine diphosphate biosynthetic process
DMB86_RS16970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DMB86_RS16970	COG2022	thiamine diphosphate biosynthetic process
DMB86_RS16975	COG0352	thiamine-phosphate diphosphorylase activity
DMB86_RS17000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DMB86_RS17005	COG2072	flavoprotein involved in K transport
DMB86_RS17020	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMB86_RS17060	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
DMB86_RS17065	COG0513	Belongs to the DEAD box helicase family
DMB86_RS17075	COG0613	PHP domain protein
DMB86_RS17080	COG0006	proline dipeptidase activity
DMB86_RS17090	COG2239	Acts as a magnesium transporter
DMB86_RS17110	COG1595	DNA-templated transcription, initiation
DMB86_RS17130	COG2818	Glycosylase
DMB86_RS17145	COG1126	abc transporter atp-binding protein
DMB86_RS17150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DMB86_RS17155	COG0765	amino acid transport
DMB86_RS17160	COG0765	amino acid transport
DMB86_RS17165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DMB86_RS17180	COG5343	regulation of RNA biosynthetic process
DMB86_RS17190	COG2171	N-acyltransferase activity
DMB86_RS17205	COG3226	Transcriptional regulator
DMB86_RS17240	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DMB86_RS17245	COG4172	Belongs to the ABC transporter superfamily
DMB86_RS17250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DMB86_RS17255	COG0601	transmembrane transport
DMB86_RS17260	COG4166	transmembrane transport
DMB86_RS17265	COG1217	gtp-binding protein TYPA
DMB86_RS17270	COG4166	transmembrane transport
DMB86_RS17275	COG2318	DinB family
DMB86_RS17335	COG0012	GTP binding
DMB86_RS17375	COG1322	Protein conserved in bacteria
DMB86_RS17380	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DMB86_RS17390	COG1570	exodeoxyribonuclease VII activity
DMB86_RS17395	COG1722	exodeoxyribonuclease VII activity
DMB86_RS17400	COG2326	polyphosphate kinase activity
DMB86_RS17420	COG1609	Transcriptional regulator
DMB86_RS17425	COG2971	BadF BadG BcrA BcrD
DMB86_RS17430	COG2070	2-Nitropropane dioxygenase
DMB86_RS17440	COG2814	Major facilitator Superfamily
DMB86_RS17470	COG0626	cystathionine gamma-synthase activity
DMB86_RS17490	COG0598	Magnesium transport protein CorA
DMB86_RS17495	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DMB86_RS17505	COG0156	8-amino-7-oxononanoate synthase activity
DMB86_RS17510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DMB86_RS17515	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DMB86_RS17530	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS17535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DMB86_RS17540	COG0477	Major facilitator Superfamily
DMB86_RS17545	COG0778	Nitroreductase
DMB86_RS17550	COG0659	secondary active sulfate transmembrane transporter activity
DMB86_RS17560	COG0039	L-malate dehydrogenase activity
DMB86_RS17575	COG1309	transcriptional regulator
DMB86_RS17580	COG1131	(ABC) transporter
DMB86_RS17595	COG0412	Dienelactone hydrolase
DMB86_RS17600	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DMB86_RS17610	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DMB86_RS17615	COG0509	glycine decarboxylation via glycine cleavage system
DMB86_RS17620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DMB86_RS17625	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DMB86_RS17625	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DMB86_RS17635	COG1113	amino acid transport
DMB86_RS17670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DMB86_RS17675	COG0488	(ABC) transporter
DMB86_RS17710	COG2855	membrane
DMB86_RS17730	COG3119	arylsulfatase activity
DMB86_RS17750	COG1940	carbohydrate kinase activity
DMB86_RS17790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DMB86_RS17795	COG2271	Major facilitator Superfamily
DMB86_RS17800	COG0583	DNA-binding transcription factor activity
DMB86_RS17835	COG2084	Dehydrogenase
DMB86_RS17845	COG1172	Belongs to the binding-protein-dependent transport system permease family
DMB86_RS17850	COG1129	ABC transporter
DMB86_RS17855	COG1879	ABC-type sugar transport system periplasmic component
DMB86_RS17865	COG1609	Transcriptional regulator
DMB86_RS17875	COG3265	gluconokinase activity
DMB86_RS17895	COG1609	Transcriptional regulator
DMB86_RS17960	COG0191	fructose-bisphosphate aldolase activity
DMB86_RS17965	COG0647	UMP catabolic process
DMB86_RS17995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DMB86_RS18015	COG0698	ribose 5-phosphate isomerase
DMB86_RS18020	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DMB86_RS18025	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DMB86_RS18165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DMB86_RS18205	COG0582	viral genome integration into host DNA
DMB86_RS18220	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS18230	COG0395	ABC-type sugar transport system, permease component
DMB86_RS18245	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DMB86_RS18270	COG1653	transport
DMB86_RS18275	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS18280	COG1278	Cold shock
DMB86_RS18300	COG3237	CsbD-like
DMB86_RS18315	COG0179	Fumarylacetoacetate (FAA) hydrolase
DMB86_RS18325	COG1609	Transcriptional regulator
DMB86_RS18335	COG1175	transmembrane transport
DMB86_RS18340	COG0395	ABC-type sugar transport system, permease component
DMB86_RS18365	COG1482	cell wall glycoprotein biosynthetic process
DMB86_RS18400	COG1940	carbohydrate kinase activity
DMB86_RS18400	COG1846	Transcriptional regulator
DMB86_RS18465	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS18470	COG1063	alcohol dehydrogenase
DMB86_RS18480	COG0765	amino acid transport
DMB86_RS18485	COG0765	amino acid transport
DMB86_RS18510	COG4948	Mandelate Racemase Muconate Lactonizing
DMB86_RS18525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DMB86_RS18560	COG3328	transposase activity
DMB86_RS18690	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DMB86_RS18695	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DMB86_RS18715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DMB86_RS18715	COG0519	Catalyzes the synthesis of GMP from XMP
DMB86_RS18735	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DMB86_RS18750	COG0516	GMP reductase activity
DMB86_RS18775	COG0459	protein refolding
DMB86_RS18780	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DMB86_RS18800	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DMB86_RS18805	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DMB86_RS18820	COG0671	phosphoesterase, PA-phosphatase related
DMB86_RS18835	COG5002	protein histidine kinase activity
DMB86_RS18845	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DMB86_RS18850	COG0456	acetyltransferase
DMB86_RS18860	COG0802	atpase or kinase
DMB86_RS18865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DMB86_RS18870	COG0438	transferase activity, transferring glycosyl groups
DMB86_RS18880	COG1404	Belongs to the peptidase S8 family
DMB86_RS18900	COG1260	myo-inositol-1-phosphate synthase
DMB86_RS18905	COG0667	Aldo Keto reductase
DMB86_RS18915	COG0736	holo-[acyl-carrier-protein] synthase activity
DMB86_RS18920	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DMB86_RS18925	COG1072	(Pantothenic acid kinase))
DMB86_RS18930	COG1970	mechanosensitive ion channel activity
DMB86_RS18935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DMB86_RS18940	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DMB86_RS18945	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DMB86_RS18950	COG0101	tRNA pseudouridine synthase activity
DMB86_RS18955	COG0203	ribosomal protein L17
DMB86_RS18960	COG0202	RNA polymerase activity
DMB86_RS18965	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DMB86_RS18970	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DMB86_RS18975	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DMB86_RS18980	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DMB86_RS18990	COG0024	Methionine aminopeptidase
DMB86_RS18995	COG0563	adenylate kinase activity
DMB86_RS19005	COG0200	Binds to the 23S rRNA
DMB86_RS19010	COG1841	ribosomal large subunit assembly
DMB86_RS19015	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DMB86_RS19020	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DMB86_RS19025	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DMB86_RS19030	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DMB86_RS19035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DMB86_RS19040	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DMB86_RS19045	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DMB86_RS19055	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DMB86_RS19060	COG0255	Belongs to the universal ribosomal protein uL29 family
DMB86_RS19065	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DMB86_RS19070	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DMB86_RS19075	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DMB86_RS19080	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DMB86_RS19085	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DMB86_RS19090	COG0089	rRNA binding
DMB86_RS19095	COG0088	Forms part of the polypeptide exit tunnel
DMB86_RS19100	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DMB86_RS19105	COG0051	transcription antitermination factor activity, RNA binding
DMB86_RS19110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DMB86_RS19115	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DMB86_RS19120	COG0049	tRNA binding
DMB86_RS19125	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DMB86_RS19130	COG1752	Esterase of the alpha-beta hydrolase superfamily
DMB86_RS19135	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DMB86_RS19140	COG0085	RNA polymerase activity
DMB86_RS19145	COG0183	Belongs to the thiolase family
DMB86_RS19150	COG0442	prolyl-tRNA aminoacylation
DMB86_RS19155	COG0222	ribosome binding
DMB86_RS19160	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DMB86_RS19170	COG0081	regulation of translation
DMB86_RS19175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DMB86_RS19180	COG0250	Participates in transcription elongation, termination and antitermination
DMB86_RS19195	COG0436	Aminotransferase
DMB86_RS19200	COG2197	response regulator
DMB86_RS19220	COG0277	FAD linked oxidase domain protein
DMB86_RS19220	COG0247	lactate metabolic process
DMB86_RS19245	COG0354	folic acid binding
DMB86_RS19250	COG3485	protocatechuate 3,4-dioxygenase
DMB86_RS19260	COG0745	RESPONSE REGULATOR receiver
DMB86_RS19265	COG0456	acetyltransferase
DMB86_RS19270	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DMB86_RS19280	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DMB86_RS19290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DMB86_RS19305	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DMB86_RS19310	COG0738	Major facilitator superfamily
DMB86_RS19315	COG2030	dehydratase
DMB86_RS19320	COG2030	dehydratase
DMB86_RS19330	COG0477	Major facilitator Superfamily
DMB86_RS19345	COG2301	Belongs to the HpcH HpaI aldolase family
DMB86_RS19350	COG0025	NhaP-type Na H and K H
DMB86_RS19365	COG0702	epimerase
DMB86_RS19400	COG1028	Short-chain dehydrogenase reductase Sdr
DMB86_RS19410	COG1652	LysM domain
DMB86_RS19440	COG0346	lactoylglutathione lyase activity
DMB86_RS19460	COG0477	Major facilitator Superfamily
DMB86_RS19490	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DMB86_RS19495	COG2079	MmgE PrpD family protein
DMB86_RS19500	COG0183	Belongs to the thiolase family
DMB86_RS19510	COG1960	acyl-CoA dehydrogenase activity
DMB86_RS19515	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMB86_RS19530	COG1802	Transcriptional regulator
DMB86_RS19535	COG0473	3-isopropylmalate dehydrogenase activity
DMB86_RS19540	COG1012	belongs to the aldehyde dehydrogenase family
DMB86_RS19550	COG2186	Transcriptional regulator
DMB86_RS19555	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DMB86_RS19560	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DMB86_RS19565	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DMB86_RS19570	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DMB86_RS19640	COG1278	Cold shock
DMB86_RS19645	COG3237	CsbD-like
DMB86_RS19660	COG1609	Transcriptional regulator
DMB86_RS19670	COG0765	amino acid transport
DMB86_RS19675	COG1126	abc transporter atp-binding protein
DMB86_RS19680	COG0673	inositol 2-dehydrogenase activity
DMB86_RS19685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DMB86_RS19785	COG1192	Involved in chromosome partitioning
DMB86_RS19835	COG1609	Transcriptional regulator
DMB86_RS19845	COG1175	transmembrane transport
DMB86_RS19850	COG0395	ABC-type sugar transport system, permease component
DMB86_RS19855	COG0673	inositol 2-dehydrogenase activity
DMB86_RS19860	COG0366	Alpha amylase catalytic
DMB86_RS19910	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DMB86_RS19915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DMB86_RS19925	COG1012	belongs to the aldehyde dehydrogenase family
DMB86_RS19930	COG0596	Alpha beta hydrolase
DMB86_RS19945	COG1802	Transcriptional regulator
DMB86_RS19965	COG0196	riboflavin kinase activity
DMB86_RS19980	COG3328	transposase activity
DMB86_RS19990	COG1414	Transcriptional regulator
DMB86_RS20000	COG0277	FAD linked oxidase domain protein
DMB86_RS20005	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DMB86_RS20015	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DMB86_RS20050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DMB86_RS20075	COG3344	reverse transcriptase
DMB86_RS20100	COG1484	DNA-dependent DNA replication
DMB86_RS20115	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DMB86_RS20120	COG4584	PFAM Integrase catalytic
DMB86_RS20120	COG2390	Transcriptional regulator
DMB86_RS20125	COG0318	PFAM AMP-dependent synthetase and ligase
DMB86_RS20140	COG0477	Major facilitator Superfamily
DMB86_RS20175	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DMB86_RS20180	COG2079	MmgE PrpD family protein
DMB86_RS20185	COG0183	Belongs to the thiolase family
DMB86_RS20310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity