locus-tag	class	description
J0916_RS00035	COG2801	Transposase and inactivated derivatives
J0916_RS00070	COG2226	methyltransferase
J0916_RS00085	COG3547	Transposase (IS116 IS110 IS902 family)
J0916_RS00095	COG4974	Belongs to the 'phage' integrase family
J0916_RS00105	COG4974	Belongs to the 'phage' integrase family
J0916_RS00115	COG0717	Belongs to the dCTP deaminase family
J0916_RS00140	COG0124	histidyl-tRNA synthetase
J0916_RS00150	COG1484	DNA-dependent DNA replication
J0916_RS00225	COG2855	membrane
J0916_RS00240	COG1012	belongs to the aldehyde dehydrogenase family
J0916_RS00245	COG0596	Alpha beta hydrolase
J0916_RS00265	COG2207	Transcriptional regulator
J0916_RS00275	COG0604	alcohol dehydrogenase
J0916_RS00305	COG0492	ferredoxin-NADP+ reductase activity
J0916_RS00370	COG2197	response regulator
J0916_RS00455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J0916_RS00525	COG2197	response regulator
J0916_RS00540	COG1126	abc transporter atp-binding protein
J0916_RS00545	COG0765	amino acid transport
J0916_RS00570	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_RS00585	COG1653	transport
J0916_RS00605	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J0916_RS00610	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J0916_RS00630	COG0667	Aldo Keto reductase
J0916_RS00635	COG0701	Predicted permease
J0916_RS00665	COG3608	succinylglutamate desuccinylase aspartoacylase
J0916_RS00675	COG0765	amino acid transport
J0916_RS00680	COG1126	abc transporter atp-binding protein
J0916_RS00690	COG1609	Transcriptional regulator
J0916_RS00695	COG0366	Alpha amylase catalytic
J0916_RS00735	COG4172	Belongs to the ABC transporter superfamily
J0916_RS00765	COG3142	Participates in the control of copper homeostasis
J0916_RS00810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J0916_RS00815	COG1012	belongs to the aldehyde dehydrogenase family
J0916_RS00845	COG1126	abc transporter atp-binding protein
J0916_RS00850	COG0765	amino acid transport
J0916_RS00855	COG0765	amino acid transport
J0916_RS00880	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_RS00885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J0916_RS00890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J0916_RS00920	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_RS00925	COG2130	NADP-dependent
J0916_RS00945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J0916_RS00955	COG3960	tartronate-semialdehyde synthase activity
J0916_RS00960	COG2084	Dehydrogenase
J0916_RS00965	COG3622	Belongs to the hyi family
J0916_RS00975	COG3257	ureidoglycine aminohydrolase activity
J0916_RS00985	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J0916_RS00995	COG1414	Transcriptional regulator
J0916_RS01000	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
J0916_RS01005	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_RS01020	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J0916_RS01025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J0916_RS01030	COG0156	8-amino-7-oxononanoate synthase activity
J0916_RS01040	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
J0916_RS01055	COG2233	PERMEase
J0916_RS01075	COG1937	Protein conserved in bacteria
J0916_RS01100	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_RS01115	COG1012	belongs to the aldehyde dehydrogenase family
J0916_RS01165	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J0916_RS01185	COG0459	protein refolding
J0916_RS01190	COG0328	RNA-DNA hybrid ribonuclease activity
J0916_RS01200	COG2205	protein histidine kinase activity
J0916_RS01205	COG0745	RESPONSE REGULATOR receiver
J0916_RS01210	COG3119	arylsulfatase activity
J0916_RS01220	COG3119	arylsulfatase activity
J0916_RS01225	COG0395	ABC-type sugar transport system, permease component
J0916_RS01230	COG1175	transmembrane transport
J0916_RS01235	COG1653	transport
J0916_RS01240	COG1609	Transcriptional regulator
J0916_RS01245	COG0673	inositol 2-dehydrogenase activity
J0916_RS01265	COG5492	domain, Protein
J0916_RS01270	COG3119	arylsulfatase activity
J0916_RS01280	COG3119	arylsulfatase activity
J0916_RS01285	COG2890	protein-(glutamine-N5) methyltransferase activity
J0916_RS01305	COG1278	Cold shock
J0916_RS01325	COG0739	heme binding
J0916_RS01330	COG3103	Sh3 type 3 domain protein
J0916_RS01330	COG1388	LysM domain
J0916_RS01330	COG0791	NLP P60 protein
J0916_RS01370	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
J0916_RS01380	COG1126	abc transporter atp-binding protein
J0916_RS01385	COG0765	amino acid transport
J0916_RS01390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J0916_RS01395	COG1132	(ABC) transporter
J0916_RS01410	COG1742	UPF0060 membrane protein
J0916_RS01430	COG0483	inositol monophosphate 1-phosphatase activity
J0916_RS01440	COG0045	succinate-CoA ligase (ADP-forming) activity
J0916_RS01475	COG0508	dehydrogenase complex catalyzes the overall conversion of
J0916_RS01495	COG1960	acyl-CoA dehydrogenase activity
J0916_RS01515	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_RS01520	COG2030	dehydratase
J0916_RS01550	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
J0916_RS01565	COG1396	sequence-specific DNA binding
J0916_RS01580	COG0028	Belongs to the TPP enzyme family
J0916_RS01585	COG1794	racemase activity, acting on amino acids and derivatives
J0916_RS01605	COG3119	arylsulfatase activity
J0916_RS01610	COG0326	Molecular chaperone. Has ATPase activity
J0916_RS01630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J0916_RS01650	COG0457	Tetratricopeptide repeat
J0916_RS01655	COG2186	Transcriptional regulator
J0916_RS01680	COG0431	NADPH-dependent FMN reductase
J0916_RS01720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J0916_RS01725	COG1574	metal-dependent hydrolase with the TIM-barrel fold
J0916_RS01745	COG0789	Transcriptional regulator
J0916_RS01750	COG0659	secondary active sulfate transmembrane transporter activity
J0916_RS01805	COG1960	acyl-CoA dehydrogenase activity
J0916_RS01820	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J0916_RS01820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J0916_RS01825	COG1278	Cold shock
J0916_RS01850	COG0477	Major facilitator Superfamily
J0916_RS01860	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
J0916_RS01865	COG1472	Belongs to the glycosyl hydrolase 3 family
J0916_RS01870	COG0138	bifunctional purine biosynthesis protein purh
J0916_RS01880	COG2838	Isocitrate dehydrogenase
J0916_RS01910	COG0673	inositol 2-dehydrogenase activity
J0916_RS01920	COG0395	ABC-type sugar transport system, permease component
J0916_RS01925	COG1175	transmembrane transport
J0916_RS01935	COG1940	carbohydrate kinase activity
J0916_RS01945	COG0667	Aldo Keto reductase
J0916_RS01955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J0916_RS01960	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J0916_RS01975	COG2197	response regulator
J0916_RS01995	COG0180	Tryptophanyl-tRNA synthetase
J0916_RS02015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J0916_RS02030	COG2009	succinate dehydrogenase
J0916_RS02035	COG0662	Cupin 2, conserved barrel domain protein
J0916_RS02035	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
J0916_RS02040	COG1473	amidohydrolase
J0916_RS02040	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
J0916_RS02045	COG1744	ABC transporter substrate-binding protein PnrA-like
J0916_RS02050	COG3845	ABC transporter
J0916_RS02055	COG4603	Belongs to the binding-protein-dependent transport system permease family
J0916_RS02060	COG1079	Belongs to the binding-protein-dependent transport system permease family
J0916_RS02080	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
J0916_RS02085	COG3956	TIGRFAM MazG family protein
J0916_RS02090	COG0148	phosphopyruvate hydratase activity
J0916_RS02145	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
J0916_RS02155	COG1349	DNA-binding transcription factor activity
J0916_RS02160	COG2017	converts alpha-aldose to the beta-anomer
J0916_RS02170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J0916_RS02175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J0916_RS02185	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J0916_RS02195	COG1331	Highly conserved protein containing a thioredoxin domain
J0916_RS02200	COG1136	(ABC) transporter
J0916_RS02200	COG0577	efflux transmembrane transporter activity
J0916_RS02215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J0916_RS02225	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
J0916_RS02250	COG0477	Major facilitator Superfamily
J0916_RS02255	COG0114	fumarate hydratase activity
J0916_RS02260	COG0288	reversible hydration of carbon dioxide
J0916_RS02270	COG1494	fructose-1,6-bisphosphatase
J0916_RS02285	COG1316	TRANSCRIPTIONal
J0916_RS02355	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J0916_RS02360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J0916_RS02365	COG1376	ErfK ybiS ycfS ynhG family protein
J0916_RS02415	COG0714	Associated with various cellular activities
J0916_RS02420	COG0084	hydrolase, TatD family'
J0916_RS02430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J0916_RS02435	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J0916_RS02440	COG0488	(ABC) transporter
J0916_RS02455	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J0916_RS02465	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J0916_RS02470	COG0193	aminoacyl-tRNA hydrolase activity
J0916_RS02490	COG0529	Catalyzes the synthesis of activated sulfate
J0916_RS02495	COG0730	response to heat
J0916_RS02515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J0916_RS02520	COG1218	3'(2'),5'-bisphosphate nucleotidase
J0916_RS02525	COG0175	sulfate reduction
J0916_RS02580	COG0822	iron-sulfur transferase activity
J0916_RS02600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J0916_RS02605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J0916_RS02625	COG5002	protein histidine kinase activity
J0916_RS02645	COG3979	chitinase
J0916_RS02660	COG0745	RESPONSE REGULATOR receiver
J0916_RS02665	COG5002	protein histidine kinase activity
J0916_RS02675	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
J0916_RS02695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J0916_RS02710	COG0733	neurotransmitter:sodium symporter activity
J0916_RS02715	COG0477	Major facilitator Superfamily
J0916_RS02760	COG2197	response regulator
J0916_RS02765	COG4770	biotin carboxylase activity
J0916_RS02780	COG0424	maF-like protein
J0916_RS02785	COG0477	Major facilitator Superfamily
J0916_RS02815	COG2409	Drug exporters of the RND superfamily
J0916_RS02825	COG1823	symporter activity
J0916_RS02830	COG1024	Enoyl-CoA hydratase
J0916_RS02840	COG0765	amino acid transport
J0916_RS02850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J0916_RS02860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J0916_RS02880	COG1176	ABC-type spermidine putrescine transport system, permease component I
J0916_RS02885	COG3842	ATPase activity
J0916_RS02910	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_RS02930	COG1960	acyl-CoA dehydrogenase activity
J0916_RS02935	COG2086	electron transfer activity
J0916_RS02940	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
J0916_RS02970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J0916_RS02995	COG0631	protein serine/threonine phosphatase activity
J0916_RS03015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J0916_RS03040	COG0395	ABC-type sugar transport system, permease component
J0916_RS03045	COG1175	transmembrane transport
J0916_RS03065	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J0916_RS03070	COG0154	amidase activity
J0916_RS03075	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J0916_RS03080	COG0583	DNA-binding transcription factor activity
J0916_RS03085	COG1063	alcohol dehydrogenase
J0916_RS03100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J0916_RS03115	COG1228	amidohydrolase
J0916_RS03155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J0916_RS03160	COG0583	DNA-binding transcription factor activity
J0916_RS03165	COG1012	belongs to the aldehyde dehydrogenase family
J0916_RS03190	COG0251	oxidation-reduction process
J0916_RS03200	COG2837	iron assimilation
J0916_RS03205	COG2822	iron ion transport
J0916_RS03210	COG0672	)-iron permease
J0916_RS03215	COG0588	phosphoglycerate mutase activity
J0916_RS03230	COG2183	response to ionizing radiation
J0916_RS03245	COG1302	Protein conserved in bacteria
J0916_RS03270	COG2873	o-acetylhomoserine
J0916_RS03275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J0916_RS03305	COG0423	glycine-tRNA ligase activity
J0916_RS03330	COG3424	synthase
J0916_RS03335	COG2124	cytochrome p450
J0916_RS03345	COG2986	histidine ammonia-lyase
J0916_RS03360	COG1126	abc transporter atp-binding protein
J0916_RS03365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J0916_RS03375	COG2239	Acts as a magnesium transporter
J0916_RS03380	COG1309	transcriptional regulator
J0916_RS03400	COG0358	DNA primase activity
J0916_RS03420	COG4682	membrane
J0916_RS03430	COG2814	Major facilitator Superfamily
J0916_RS03465	COG1960	acyl-CoA dehydrogenase activity
J0916_RS03475	COG0052	Belongs to the universal ribosomal protein uS2 family
J0916_RS03480	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J0916_RS03485	COG0528	UMP kinase activity
J0916_RS03490	COG0233	cytoplasmic translational termination
J0916_RS03510	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J0916_RS03520	COG3279	Response regulator of the LytR AlgR family
J0916_RS03530	COG3275	phosphorelay sensor kinase activity
J0916_RS03540	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J0916_RS03565	COG0022	dehydrogenase e1 component
J0916_RS03570	COG0508	dehydrogenase complex catalyzes the overall conversion of
J0916_RS03575	COG1309	transcriptional regulator
J0916_RS03580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J0916_RS03590	COG1960	acyl-CoA dehydrogenase activity
J0916_RS03630	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J0916_RS03635	COG0750	zinc metalloprotease
J0916_RS03655	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J0916_RS03670	COG0477	Major facilitator Superfamily
J0916_RS03675	COG1902	pentaerythritol trinitrate reductase activity
J0916_RS03675	COG0446	pyridine nucleotide-disulphide oxidoreductase
J0916_RS03690	COG1131	(ABC) transporter
J0916_RS03695	COG0442	prolyl-tRNA aminoacylation
J0916_RS03765	COG0196	riboflavin kinase activity
J0916_RS03770	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J0916_RS03775	COG1185	polyribonucleotide nucleotidyltransferase activity
J0916_RS03780	COG0612	Peptidase, M16
J0916_RS03800	COG0315	cyclic pyranopterin monophosphate synthase activity
J0916_RS03800	COG0521	Mo-molybdopterin cofactor biosynthetic process
J0916_RS03810	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J0916_RS03825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J0916_RS03830	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
J0916_RS03835	COG1674	ftsk spoiiie
J0916_RS03845	COG1058	Belongs to the CinA family
J0916_RS03845	COG1546	Belongs to the CinA family
J0916_RS03865	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J0916_RS03870	COG2137	regulation of response to DNA damage stimulus
J0916_RS03880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J0916_RS03885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J0916_RS03890	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J0916_RS03895	COG2813	Specifically methylates the guanine in position
J0916_RS03900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J0916_RS03910	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J0916_RS03925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J0916_RS03930	COG0131	Imidazoleglycerol-phosphate dehydratase
J0916_RS03945	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J0916_RS03965	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J0916_RS03975	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J0916_RS03980	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J0916_RS03985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J0916_RS03995	COG2814	Major facilitator Superfamily
J0916_RS04015	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_RS04030	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J0916_RS04035	COG0072	phenylalanine-tRNA ligase activity
J0916_RS04035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J0916_RS04110	COG1597	lipid kinase activity
J0916_RS04115	COG3237	CsbD-like
J0916_RS04120	COG0640	Transcriptional regulator
J0916_RS04145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J0916_RS04150	COG2267	carboxylic ester hydrolase activity
J0916_RS04175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J0916_RS04180	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
J0916_RS04185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J0916_RS04190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J0916_RS04195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J0916_RS04200	COG1438	arginine binding
J0916_RS04205	COG0137	argininosuccinate synthase activity
J0916_RS04210	COG0165	Argininosuccinate lyase
J0916_RS04235	COG2094	Belongs to the DNA glycosylase MPG family
J0916_RS04240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J0916_RS04250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J0916_RS04285	COG0647	UMP catabolic process
J0916_RS04300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J0916_RS04305	COG0497	DNA recombination
J0916_RS04310	COG0504	CTP synthase activity
J0916_RS04355	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
J0916_RS04360	COG2079	MmgE PrpD family protein
J0916_RS04365	COG2186	Transcriptional regulator
J0916_RS04395	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
J0916_RS04400	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J0916_RS04425	COG1160	GTP binding
J0916_RS04455	COG1960	acyl-CoA dehydrogenase activity
J0916_RS04470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J0916_RS04475	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J0916_RS04485	COG0509	glycine decarboxylation via glycine cleavage system
J0916_RS04490	COG1716	ATPase activity
J0916_RS04515	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J0916_RS04515	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J0916_RS04530	COG1940	carbohydrate kinase activity
J0916_RS04545	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
J0916_RS04550	COG0515	serine threonine protein kinase
J0916_RS04550	COG2815	serine threonine protein kinase
J0916_RS04555	COG3942	CHAP domain
J0916_RS04555	COG1388	LysM domain
J0916_RS04565	COG0142	geranyltranstransferase activity
J0916_RS04575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J0916_RS04585	COG2001	Belongs to the MraZ family
J0916_RS04590	COG0275	rRNA processing
J0916_RS04595	COG0768	penicillin binding
J0916_RS04600	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J0916_RS04615	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J0916_RS04625	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J0916_RS04640	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J0916_RS04650	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J0916_RS04655	COG1799	cell septum assembly
J0916_RS04670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J0916_RS04680	COG0587	DNA-directed DNA polymerase activity
J0916_RS04690	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J0916_RS04695	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J0916_RS04715	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J0916_RS04720	COG0174	glutamine synthetase
J0916_RS04725	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
J0916_RS04735	COG0765	amino acid transport
J0916_RS04740	COG1126	abc transporter atp-binding protein
J0916_RS04745	COG2066	Belongs to the glutaminase family
J0916_RS04765	COG0667	Aldo Keto reductase
J0916_RS04770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J0916_RS04780	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J0916_RS04785	COG0321	lipoyl(octanoyl) transferase activity
J0916_RS04805	COG0508	dehydrogenase complex catalyzes the overall conversion of
J0916_RS04810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J0916_RS04815	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J0916_RS04830	COG2223	nitrite transmembrane transporter activity
J0916_RS04845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J0916_RS04855	COG0187	DNA topoisomerase II activity
J0916_RS04860	COG0501	Belongs to the peptidase M48B family
J0916_RS04870	COG1271	oxidase subunit
J0916_RS04875	COG1294	oxidase, subunit
J0916_RS04880	COG4988	ABC transporter
J0916_RS04890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J0916_RS04925	COG0756	dUTP diphosphatase activity
J0916_RS04950	COG0569	domain protein
J0916_RS04955	COG0531	amino acid
J0916_RS04960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J0916_RS04970	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J0916_RS04975	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J0916_RS04990	COG0667	Aldo Keto reductase
J0916_RS04995	COG3345	alpha-galactosidase
J0916_RS05005	COG1024	Enoyl-CoA hydratase
J0916_RS05005	COG1250	3-hydroxyacyl-CoA dehydrogenase
J0916_RS05010	COG0183	Belongs to the thiolase family
J0916_RS05015	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
J0916_RS05040	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J0916_RS05055	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J0916_RS05130	COG0242	peptide deformylase activity
J0916_RS05135	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J0916_RS05145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J0916_RS05165	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J0916_RS05165	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J0916_RS05170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J0916_RS05175	COG0140	phosphoribosyl-ATP diphosphatase activity
J0916_RS05180	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J0916_RS05185	COG0107	imidazoleglycerol-phosphate synthase activity
J0916_RS05195	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J0916_RS05215	COG0134	indole-3-glycerol-phosphate synthase activity
J0916_RS05220	COG0133	tryptophan synthase activity
J0916_RS05225	COG0159	tryptophan synthase activity
J0916_RS05230	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J0916_RS05235	COG0067	glutamate synthase
J0916_RS05235	COG0069	glutamate synthase activity
J0916_RS05235	COG0070	glutamate synthase
J0916_RS05265	COG0582	viral genome integration into host DNA
J0916_RS05270	COG0582	viral genome integration into host DNA
J0916_RS05275	COG4974	Belongs to the 'phage' integrase family
J0916_RS05340	COG0583	DNA-binding transcription factor activity
J0916_RS05350	COG1012	belongs to the aldehyde dehydrogenase family
J0916_RS05375	COG1597	lipid kinase activity
J0916_RS05380	COG0671	phosphoesterase, PA-phosphatase related
J0916_RS05400	COG1191	sigma factor activity
J0916_RS05410	COG2197	response regulator
J0916_RS05455	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_RS05525	COG2801	Transposase and inactivated derivatives
J0916_RS05580	COG2132	Multicopper oxidase
J0916_RS05600	COG2217	Heavy metal translocating P-type atpase
J0916_RS05610	COG3237	CsbD-like
J0916_RS05620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
J0916_RS05630	COG0071	Belongs to the small heat shock protein (HSP20) family
J0916_RS05635	COG0789	Transcriptional regulator
J0916_RS05655	COG0028	Belongs to the TPP enzyme family
J0916_RS05660	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J0916_RS05675	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_RS05685	COG2017	converts alpha-aldose to the beta-anomer
J0916_RS05755	COG2197	response regulator
J0916_RS05815	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J0916_RS05835	COG2205	protein histidine kinase activity
J0916_RS05840	COG0745	RESPONSE REGULATOR receiver
J0916_RS05850	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J0916_RS05880	COG2801	Transposase and inactivated derivatives
J0916_RS05885	COG0745	RESPONSE REGULATOR receiver
J0916_RS05890	COG5002	protein histidine kinase activity
J0916_RS05900	COG2132	Multicopper oxidase
J0916_RS05900	COG2132	Multicopper oxidase
J0916_RS05935	COG3511	phospholipase C
J0916_RS05955	COG0426	domain, Protein
J0916_RS05955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J0916_RS05960	COG1063	alcohol dehydrogenase
J0916_RS05970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J0916_RS05970	COG0574	Belongs to the PEP-utilizing enzyme family
J0916_RS05980	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
J0916_RS05985	COG0589	response to stress
J0916_RS06005	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J0916_RS06010	COG0028	Belongs to the TPP enzyme family
J0916_RS06015	COG0069	glutamate synthase activity
J0916_RS06030	COG0438	transferase activity, transferring glycosyl groups
J0916_RS06050	COG0166	Belongs to the GPI family
J0916_RS06055	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
J0916_RS06070	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J0916_RS06075	COG1053	succinate dehydrogenase
J0916_RS06090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J0916_RS06095	COG0477	Major facilitator Superfamily
J0916_RS06100	COG3959	Transketolase, thiamine diphosphate binding domain
J0916_RS06105	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J0916_RS06110	COG1017	nitric oxide dioxygenase activity
J0916_RS06110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J0916_RS06125	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J0916_RS06135	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
J0916_RS06140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J0916_RS06145	COG4948	Mandelate Racemase Muconate Lactonizing
J0916_RS06150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J0916_RS06155	COG2186	Transcriptional regulator
J0916_RS06160	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
J0916_RS06170	COG5002	protein histidine kinase activity
J0916_RS06175	COG0745	RESPONSE REGULATOR receiver
J0916_RS06205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J0916_RS06215	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
J0916_RS06220	COG1854	S-ribosylhomocysteine lyase activity
J0916_RS06245	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J0916_RS06250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J0916_RS06315	COG1695	Transcriptional regulator
J0916_RS06320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J0916_RS06330	COG1121	(ABC) transporter
J0916_RS06335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J0916_RS06350	COG3119	arylsulfatase activity
J0916_RS06370	COG1940	carbohydrate kinase activity
J0916_RS06375	COG0135	phosphoribosylanthranilate isomerase activity
J0916_RS06395	COG2268	Band 7 protein
J0916_RS06420	COG1643	Atp-dependent helicase
J0916_RS06435	COG0783	Belongs to the Dps family
J0916_RS06440	COG0009	L-threonylcarbamoyladenylate synthase
J0916_RS06500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J0916_RS06510	COG1116	anion transmembrane transporter activity
J0916_RS06545	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
J0916_RS06555	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J0916_RS06565	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J0916_RS06570	COG0242	peptide deformylase activity
J0916_RS06575	COG2226	methyltransferase
J0916_RS06600	COG1216	Glycosyl transferase, family 2
J0916_RS06605	COG1574	metal-dependent hydrolase with the TIM-barrel fold
J0916_RS06610	COG4581	dead DEAH box helicase
J0916_RS06615	COG0805	protein transport
J0916_RS06620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J0916_RS06635	COG0545	Peptidyl-prolyl cis-trans isomerase
J0916_RS06640	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
J0916_RS06645	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
J0916_RS06650	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
J0916_RS06660	COG4122	O-methyltransferase activity
J0916_RS06665	COG1222	aaa ATPase
J0916_RS06680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J0916_RS06690	COG0215	cysteine-tRNA ligase activity
J0916_RS06695	COG1968	undecaprenyl-diphosphatase activity
J0916_RS06700	COG0667	Aldo Keto reductase
J0916_RS06720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J0916_RS06740	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_RS06745	COG0183	Belongs to the thiolase family
J0916_RS06780	COG0297	glycogen (starch) synthase activity
J0916_RS06785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
J0916_RS06795	COG2855	membrane
J0916_RS06810	COG0095	Lipoate-protein ligase
J0916_RS06815	COG0254	rRNA binding
J0916_RS06835	COG1119	ATPase activity
J0916_RS06840	COG0560	Phosphoserine phosphatase
J0916_RS06840	COG3830	Belongs to the UPF0237 family
J0916_RS06845	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_RS06850	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_RS06875	COG0488	(ABC) transporter
J0916_RS06880	COG1268	BioY protein
J0916_RS06885	COG1122	ATPase activity
J0916_RS06900	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_RS06910	COG2151	metal-sulfur cluster biosynthetic enzyme
J0916_RS06915	COG0396	ATPase activity
J0916_RS06940	COG1131	(ABC) transporter
J0916_RS06950	COG1612	heme a metabolic process
J0916_RS06960	COG0109	protoheme IX farnesyltransferase activity
J0916_RS06970	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J0916_RS06975	COG0166	Belongs to the GPI family
J0916_RS06990	COG0363	glucosamine-6-phosphate deaminase activity
J0916_RS06995	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J0916_RS07000	COG0149	triose-phosphate isomerase activity
J0916_RS07005	COG0126	phosphoglycerate kinase activity
J0916_RS07010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J0916_RS07015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J0916_RS07020	COG1481	regulation of sporulation
J0916_RS07025	COG0391	Required for morphogenesis under gluconeogenic growth conditions
J0916_RS07030	COG1660	Displays ATPase and GTPase activities
J0916_RS07035	COG0322	excinuclease ABC activity
J0916_RS07040	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_RS07040	COG0204	Acyl-transferase
J0916_RS07075	COG4106	trans-aconitate 2-methyltransferase activity
J0916_RS07095	COG0556	nucleotide-excision repair
J0916_RS07105	COG0237	dephospho-CoA kinase activity
J0916_RS07105	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
J0916_RS07110	COG1739	Uncharacterized protein family UPF0029
J0916_RS07120	COG0539	negative regulation of cytoplasmic translation
J0916_RS07140	COG2050	protein possibly involved in aromatic compounds catabolism
J0916_RS07155	COG0436	Aminotransferase
J0916_RS07165	COG2261	transglycosylase associated protein
J0916_RS07170	COG1295	ribonuclease BN
J0916_RS07190	COG0673	inositol 2-dehydrogenase activity
J0916_RS07205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J0916_RS07210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J0916_RS07215	COG3842	ATPase activity
J0916_RS07230	COG1177	transmembrane transport
J0916_RS07235	COG1522	sequence-specific DNA binding
J0916_RS07245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J0916_RS07250	COG1012	belongs to the aldehyde dehydrogenase family
J0916_RS07255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J0916_RS07290	COG0109	protoheme IX farnesyltransferase activity
J0916_RS07310	COG3142	Participates in the control of copper homeostasis
J0916_RS07315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J0916_RS07320	COG1845	cytochrome c oxidase, subunit III
J0916_RS07325	COG2010	Cytochrome c
J0916_RS07330	COG0723	plastoquinol--plastocyanin reductase activity
J0916_RS07335	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J0916_RS07340	COG2188	Transcriptional regulator
J0916_RS07355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J0916_RS07360	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J0916_RS07380	COG0667	Aldo Keto reductase
J0916_RS07385	COG0167	dihydroorotate dehydrogenase activity
J0916_RS07400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J0916_RS07405	COG1381	Involved in DNA repair and RecF pathway recombination
J0916_RS07410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J0916_RS07415	COG3590	peptidase
J0916_RS07420	COG1316	TRANSCRIPTIONal
J0916_RS07425	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J0916_RS07435	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J0916_RS07455	COG0484	heat shock protein binding
J0916_RS07460	COG1420	regulation of RNA biosynthetic process
J0916_RS07475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J0916_RS07480	COG0481	GTPase activity
J0916_RS07490	COG0268	Binds directly to 16S ribosomal RNA
J0916_RS07510	COG1307	EDD domain protein, DegV family
J0916_RS07515	COG0495	leucyl-tRNA aminoacylation
J0916_RS07520	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J0916_RS07525	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J0916_RS07530	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
J0916_RS07535	COG2390	Transcriptional regulator
J0916_RS07590	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J0916_RS07595	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J0916_RS07605	COG1758	RNA polymerase activity
J0916_RS07610	COG0194	GDP metabolic process
J0916_RS07625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J0916_RS07630	COG0505	Belongs to the CarA family
J0916_RS07635	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J0916_RS07640	COG0540	Belongs to the ATCase OTCase family
J0916_RS07645	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
J0916_RS07655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J0916_RS07660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J0916_RS07670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J0916_RS07675	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J0916_RS07680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J0916_RS07685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J0916_RS07695	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J0916_RS07700	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J0916_RS07715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J0916_RS07730	COG0531	amino acid
J0916_RS07735	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J0916_RS07740	COG0124	histidyl-tRNA synthetase
J0916_RS07750	COG1196	nuclear chromosome segregation
J0916_RS07755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J0916_RS07760	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J0916_RS07765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J0916_RS07775	COG2255	four-way junction helicase activity
J0916_RS07780	COG0632	four-way junction helicase activity
J0916_RS07785	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J0916_RS07790	COG0217	transcriptional regulatory protein
J0916_RS07795	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
J0916_RS07800	COG0367	asparagine synthase
J0916_RS07815	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
J0916_RS07820	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J0916_RS07830	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J0916_RS07835	COG0587	DNA-directed DNA polymerase activity
J0916_RS07840	COG0456	acetyltransferase
J0916_RS07850	COG2135	peptidase activity
J0916_RS07885	COG0739	heme binding
J0916_RS07885	COG0741	lytic transglycosylase activity
J0916_RS07885	COG1196	nuclear chromosome segregation
J0916_RS07890	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_RS07905	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J0916_RS07910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J0916_RS07915	COG1780	Probably involved in ribonucleotide reductase function
J0916_RS07930	COG1012	belongs to the aldehyde dehydrogenase family
J0916_RS07955	COG2813	Specifically methylates the guanine in position
J0916_RS07960	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J0916_RS07965	COG3012	SEC-C Motif Domain Protein
J0916_RS07970	COG2188	Transcriptional regulator
J0916_RS07990	COG0799	negative regulation of ribosome biogenesis
J0916_RS07995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J0916_RS08005	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J0916_RS08010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J0916_RS08020	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J0916_RS08025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J0916_RS08030	COG0351	phosphomethylpyrimidine kinase
J0916_RS08030	COG0352	thiamine-phosphate diphosphorylase activity
J0916_RS08030	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
J0916_RS08035	COG1530	ribonuclease E activity
J0916_RS08050	COG0105	UTP biosynthetic process
J0916_RS08060	COG0285	dihydrofolate synthase activity
J0916_RS08065	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J0916_RS08075	COG2271	Major facilitator Superfamily
J0916_RS08080	COG1802	Transcriptional regulator
J0916_RS08100	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
J0916_RS08110	COG0583	DNA-binding transcription factor activity
J0916_RS08115	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
J0916_RS08120	COG0829	nickel cation binding
J0916_RS08125	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
J0916_RS08130	COG0830	nickel cation binding
J0916_RS08135	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
J0916_RS08140	COG0804	urea catabolic process
J0916_RS08145	COG0832	Belongs to the urease beta subunit family
J0916_RS08150	COG0831	urea catabolic process
J0916_RS08170	COG2271	Major facilitator Superfamily
J0916_RS08180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J0916_RS08190	COG1960	acyl-CoA dehydrogenase activity
J0916_RS08195	COG3189	MarR family transcriptional regulator
J0916_RS08205	COG0525	valine-tRNA ligase activity
J0916_RS08210	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J0916_RS08215	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J0916_RS08220	COG0740	serine-type endopeptidase activity
J0916_RS08225	COG0740	serine-type endopeptidase activity
J0916_RS08230	COG0544	peptidyl-prolyl cis-trans isomerase activity
J0916_RS08250	COG0698	ribose 5-phosphate isomerase
J0916_RS08275	COG0668	transmembrane transport
J0916_RS08280	COG2346	COG2346, Truncated hemoglobins
J0916_RS08295	COG1946	Acyl-CoA thioesterase
J0916_RS08310	COG0629	single-stranded DNA binding
J0916_RS08325	COG0531	amino acid
J0916_RS08335	COG1012	belongs to the aldehyde dehydrogenase family
J0916_RS08360	COG1960	acyl-CoA dehydrogenase activity
J0916_RS08370	COG0473	3-isopropylmalate dehydrogenase activity
J0916_RS08400	COG0076	glutamate decarboxylase activity
J0916_RS08405	COG2890	protein-(glutamine-N5) methyltransferase activity
J0916_RS08445	COG0242	peptide deformylase activity
J0916_RS08455	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J0916_RS08480	COG1484	DNA-dependent DNA replication
J0916_RS08505	COG3022	response to hydroperoxide
J0916_RS08510	COG0346	lactoylglutathione lyase activity
J0916_RS08520	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
J0916_RS08525	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J0916_RS08535	COG1045	serine acetyltransferase
J0916_RS08540	COG0024	Methionine aminopeptidase
J0916_RS08545	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
J0916_RS08555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J0916_RS08580	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
J0916_RS08595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J0916_RS08600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J0916_RS08605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J0916_RS08615	COG4974	Belongs to the 'phage' integrase family
J0916_RS08620	COG1316	TRANSCRIPTIONal
J0916_RS08635	COG0792	nuclease activity
J0916_RS08645	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J0916_RS08655	COG0681	Belongs to the peptidase S26 family
J0916_RS08660	COG0335	large ribosomal subunit rRNA binding
J0916_RS08665	COG0336	Belongs to the RNA methyltransferase TrmD family
J0916_RS08670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J0916_RS08675	COG1837	Belongs to the UPF0109 family
J0916_RS08680	COG0228	four-way junction DNA binding
J0916_RS08695	COG4172	Belongs to the ABC transporter superfamily
J0916_RS08700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J0916_RS08720	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J0916_RS08765	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_RS08770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J0916_RS08775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J0916_RS08780	COG0571	ribonuclease III activity
J0916_RS08785	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J0916_RS08795	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J0916_RS08800	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_RS08820	COG0673	inositol 2-dehydrogenase activity
J0916_RS08830	COG2268	Band 7 protein
J0916_RS08850	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J0916_RS08855	COG3483	tryptophan 2,3-dioxygenase activity
J0916_RS08875	COG0742	ribosomal rna small subunit methyltransferase
J0916_RS08885	COG1461	Dihydroxyacetone kinase
J0916_RS08905	COG3345	alpha-galactosidase
J0916_RS08915	COG0395	ABC-type sugar transport system, permease component
J0916_RS08920	COG1175	transmembrane transport
J0916_RS08940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J0916_RS08945	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
J0916_RS08965	COG2826	transposase and inactivated derivatives, IS30 family
J0916_RS08975	COG1484	DNA-dependent DNA replication
J0916_RS08985	COG1215	transferase activity, transferring glycosyl groups
J0916_RS08985	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
J0916_RS08990	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
J0916_RS09000	COG1134	teichoic acid transport
J0916_RS09000	COG1388	LysM domain
J0916_RS09010	COG0438	transferase activity, transferring glycosyl groups
J0916_RS09030	COG0463	Glycosyl transferase, family 2
J0916_RS09030	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
J0916_RS09035	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
J0916_RS09085	COG1316	TRANSCRIPTIONal
J0916_RS09095	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
J0916_RS09105	COG1181	Belongs to the D-alanine--D-alanine ligase family
J0916_RS09110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J0916_RS09120	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J0916_RS09125	COG1132	(ABC) transporter
J0916_RS09135	COG0066	3-isopropylmalate dehydratase activity
J0916_RS09140	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J0916_RS09145	COG1414	Transcriptional regulator
J0916_RS09185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J0916_RS09195	COG2197	response regulator
J0916_RS09200	COG4585	Histidine kinase
J0916_RS09205	COG0179	Fumarylacetoacetate (FAA) hydrolase
J0916_RS09210	COG2116	formate transmembrane transporter activity
J0916_RS09220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J0916_RS09225	COG0473	3-isopropylmalate dehydrogenase activity
J0916_RS09230	COG0415	Belongs to the DNA photolyase family
J0916_RS09265	COG0702	epimerase
J0916_RS09270	COG4585	Histidine kinase
J0916_RS09275	COG2197	response regulator
J0916_RS09285	COG1175	transmembrane transport
J0916_RS09290	COG1653	transport
J0916_RS09300	COG2188	Transcriptional regulator
J0916_RS09305	COG0577	efflux transmembrane transporter activity
J0916_RS09305	COG1136	(ABC) transporter
J0916_RS09325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J0916_RS09330	COG0440	acetolactate synthase activity
J0916_RS09335	COG0028	Belongs to the TPP enzyme family
J0916_RS09340	COG0129	dihydroxy-acid dehydratase activity
J0916_RS09355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J0916_RS09370	COG0747	negative chemotaxis
J0916_RS09375	COG0579	oxidoreductase
J0916_RS09380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J0916_RS09390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J0916_RS09410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J0916_RS09430	COG2205	protein histidine kinase activity
J0916_RS09460	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
J0916_RS09465	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
J0916_RS09475	COG1113	amino acid transport
J0916_RS09490	COG0419	ATPase involved in DNA repair
J0916_RS09495	COG0420	3'-5' exonuclease activity
J0916_RS09515	COG2149	membrane
J0916_RS09535	COG0586	Pfam SNARE associated Golgi protein
J0916_RS09540	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J0916_RS09545	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J0916_RS09555	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J0916_RS09565	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
J0916_RS09570	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
J0916_RS09575	COG1335	isochorismatase
J0916_RS09590	COG0363	glucosamine-6-phosphate deaminase activity
J0916_RS09600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J0916_RS09605	COG0628	permease
J0916_RS09625	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
J0916_RS09630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J0916_RS09640	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
J0916_RS09645	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
J0916_RS09655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J0916_RS09660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J0916_RS09665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J0916_RS09670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J0916_RS09675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J0916_RS09680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J0916_RS09685	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J0916_RS09690	COG0356	it plays a direct role in the translocation of protons across the membrane
J0916_RS09700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J0916_RS09725	COG2890	protein-(glutamine-N5) methyltransferase activity
J0916_RS09730	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J0916_RS09740	COG0083	homoserine kinase activity
J0916_RS09745	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
J0916_RS09755	COG0019	diaminopimelate decarboxylase activity
J0916_RS09760	COG0018	arginyl-trna synthetase
J0916_RS09790	COG2211	Major facilitator Superfamily
J0916_RS09795	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J0916_RS09825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J0916_RS09830	COG0537	adenosine 5'-monophosphoramidase activity
J0916_RS09835	COG1064	alcohol dehydrogenase
J0916_RS09845	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
J0916_RS09870	COG3842	ATPase activity
J0916_RS09885	COG1253	flavin adenine dinucleotide binding
J0916_RS09900	COG3265	gluconokinase activity
J0916_RS09905	COG0246	Mannitol dehydrogenase
J0916_RS09910	COG2186	Transcriptional regulator
J0916_RS09915	COG1063	alcohol dehydrogenase
J0916_RS09925	COG1175	transmembrane transport
J0916_RS09935	COG4948	Mandelate Racemase Muconate Lactonizing
J0916_RS09945	COG0508	dehydrogenase complex catalyzes the overall conversion of
J0916_RS09945	COG0567	Dehydrogenase, E1 component
J0916_RS09965	COG1595	DNA-templated transcription, initiation
J0916_RS09975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J0916_RS09985	COG0483	inositol monophosphate 1-phosphatase activity
J0916_RS10005	COG1321	iron dependent repressor
J0916_RS10010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J0916_RS10035	COG1472	Belongs to the glycosyl hydrolase 3 family
J0916_RS10040	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J0916_RS10050	COG2177	Part of the ABC transporter FtsEX involved in
J0916_RS10055	COG2884	Cell division ATP-binding protein ftsE
J0916_RS10060	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
J0916_RS10125	COG1132	(ABC) transporter
J0916_RS10155	COG0673	inositol 2-dehydrogenase activity
J0916_RS10165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J0916_RS10175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J0916_RS10185	COG1088	dTDP-glucose 4,6-dehydratase activity
J0916_RS10190	COG0463	Glycosyl transferase, family 2
J0916_RS10195	COG1216	Glycosyl transferase, family 2
J0916_RS10205	COG0463	Glycosyl transferase, family 2
J0916_RS10205	COG1216	Glycosyl transferase, family 2
J0916_RS10215	COG2755	lipolytic protein G-D-S-L family
J0916_RS10215	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J0916_RS10225	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
J0916_RS10240	COG1216	Glycosyl transferase, family 2
J0916_RS10255	COG1674	ftsk spoiiie
J0916_RS10270	COG2902	Dehydrogenase
J0916_RS10295	COG0653	protein targeting
J0916_RS10305	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
J0916_RS10310	COG1040	competence protein
J0916_RS10315	COG5401	PFAM Sporulation and spore germination
J0916_RS10320	COG5002	protein histidine kinase activity
J0916_RS10320	COG5000	phosphorelay sensor kinase activity
J0916_RS10325	COG0745	RESPONSE REGULATOR receiver
J0916_RS10340	COG0714	Associated with various cellular activities
J0916_RS10365	COG4172	Belongs to the ABC transporter superfamily
J0916_RS10370	COG4171	peptide transport system, permease
J0916_RS10375	COG0601	transmembrane transport
J0916_RS10390	COG0482	sulfurtransferase activity
J0916_RS10400	COG0302	gtp cyclohydrolase
J0916_RS10410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J0916_RS10420	COG1597	lipid kinase activity
J0916_RS10425	COG0484	heat shock protein binding
J0916_RS10430	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J0916_RS10440	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
J0916_RS10445	COG2086	electron transfer activity
J0916_RS10460	COG1842	Phage shock protein A
J0916_RS10475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J0916_RS10480	COG0531	amino acid
J0916_RS10485	COG1309	transcriptional regulator
J0916_RS10490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
J0916_RS10495	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_RS10500	COG0183	Belongs to the thiolase family
J0916_RS10510	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_RS10515	COG1024	Enoyl-CoA hydratase
J0916_RS10520	COG1960	acyl-CoA dehydrogenase activity
J0916_RS10550	COG0640	Transcriptional regulator
J0916_RS10570	COG2161	toxin-antitoxin pair type II binding
J0916_RS10605	COG1131	(ABC) transporter
J0916_RS10630	COG1280	lysine exporter protein (LysE YggA)
J0916_RS10650	COG0384	phenazine biosynthesis protein PhzF
J0916_RS10665	COG2826	transposase and inactivated derivatives, IS30 family
J0916_RS10675	COG3344	reverse transcriptase
J0916_RS10685	COG3585	molybdate ion transport
J0916_RS10710	COG1902	pentaerythritol trinitrate reductase activity
J0916_RS10715	COG1024	Enoyl-CoA hydratase
J0916_RS10725	COG1024	Enoyl-CoA hydratase
J0916_RS10730	COG1960	acyl-CoA dehydrogenase activity
J0916_RS10740	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
J0916_RS10745	COG2086	electron transfer activity
J0916_RS10750	COG1846	Transcriptional regulator
J0916_RS10755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J0916_RS10760	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_RS10765	COG1024	Enoyl-CoA hydratase
J0916_RS10775	COG0183	Belongs to the thiolase family
J0916_RS10785	COG1024	Enoyl-CoA hydratase
J0916_RS10795	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_RS10800	COG0318	PFAM AMP-dependent synthetase and ligase
J0916_RS10825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J0916_RS10845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J0916_RS10855	COG1615	UPF0182 protein
J0916_RS10860	COG3480	Lon protease (S16) C-terminal proteolytic domain
J0916_RS10900	COG0210	DNA helicase
J0916_RS10920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J0916_RS10925	COG0765	amino acid transport
J0916_RS10930	COG1126	abc transporter atp-binding protein
J0916_RS10945	COG0463	Glycosyl transferase, family 2
J0916_RS10950	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J0916_RS10965	COG0181	hydroxymethylbilane synthase activity
J0916_RS10970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J0916_RS10985	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J0916_RS10990	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
J0916_RS11020	COG2154	pterin-4-alpha-carbinolamine dehydratase
J0916_RS11025	COG2022	thiamine diphosphate biosynthetic process
J0916_RS11035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J0916_RS11035	COG2022	thiamine diphosphate biosynthetic process
J0916_RS11040	COG0352	thiamine-phosphate diphosphorylase activity
J0916_RS11055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J0916_RS11060	COG2072	flavoprotein involved in K transport
J0916_RS11080	COG0515	serine threonine protein kinase
J0916_RS11085	COG0433	COG0433 Predicted ATPase
J0916_RS11085	COG1674	ftsk spoiiie
J0916_RS11130	COG2271	Major facilitator Superfamily
J0916_RS11140	COG1012	belongs to the aldehyde dehydrogenase family
J0916_RS11145	COG0583	DNA-binding transcription factor activity
J0916_RS11160	COG2814	Major facilitator Superfamily
J0916_RS11165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J0916_RS11185	COG0513	Belongs to the DEAD box helicase family
J0916_RS11205	COG0006	proline dipeptidase activity
J0916_RS11220	COG2239	Acts as a magnesium transporter
J0916_RS11240	COG1595	DNA-templated transcription, initiation
J0916_RS11260	COG0519	Catalyzes the synthesis of GMP from XMP
J0916_RS11275	COG1126	abc transporter atp-binding protein
J0916_RS11280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J0916_RS11285	COG0765	amino acid transport
J0916_RS11290	COG0765	amino acid transport
J0916_RS11295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J0916_RS11320	COG2171	N-acyltransferase activity
J0916_RS11360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J0916_RS11370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J0916_RS11375	COG0601	transmembrane transport
J0916_RS11380	COG4166	transmembrane transport
J0916_RS11400	COG1231	oxidoreductase activity
J0916_RS11440	COG0012	GTP binding
J0916_RS11445	COG1322	Protein conserved in bacteria
J0916_RS11450	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J0916_RS11455	COG1570	exodeoxyribonuclease VII activity
J0916_RS11460	COG1722	exodeoxyribonuclease VII activity
J0916_RS11470	COG2326	polyphosphate kinase activity
J0916_RS11490	COG1609	Transcriptional regulator
J0916_RS11495	COG2971	BadF BadG BcrA BcrD
J0916_RS11500	COG2070	2-Nitropropane dioxygenase
J0916_RS11510	COG0598	Magnesium transport protein CorA
J0916_RS11515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J0916_RS11520	COG0778	Nitroreductase
J0916_RS11530	COG0039	L-malate dehydrogenase activity
J0916_RS11535	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
J0916_RS11540	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
J0916_RS11555	COG1309	transcriptional regulator
J0916_RS11560	COG1131	(ABC) transporter
J0916_RS11585	COG1846	Transcriptional regulator
J0916_RS11590	COG2409	Drug exporters of the RND superfamily
J0916_RS11595	COG0488	(ABC) transporter
J0916_RS11630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J0916_RS11645	COG0477	Major facilitator Superfamily
J0916_RS11660	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
J0916_RS11685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J0916_RS11690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J0916_RS11695	COG3711	transcriptional antiterminator
J0916_RS11700	COG1263	PTS System
J0916_RS11700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J0916_RS11700	COG2190	(PTS) system
J0916_RS11705	COG1263	PTS System
J0916_RS11705	COG2190	(PTS) system
J0916_RS11705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J0916_RS11715	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
J0916_RS11725	COG1846	Transcriptional regulator
J0916_RS11730	COG1764	response to oxidative stress
J0916_RS11755	COG0783	Belongs to the Dps family
J0916_RS11880	COG1175	transmembrane transport
J0916_RS11885	COG0395	ABC-type sugar transport system, permease component
J0916_RS11910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J0916_RS11935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J0916_RS11935	COG0519	Catalyzes the synthesis of GMP from XMP
J0916_RS11955	COG0516	GMP reductase activity
J0916_RS11975	COG2217	Heavy metal translocating P-type atpase
J0916_RS11980	COG0459	protein refolding
J0916_RS11985	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J0916_RS11990	COG1131	(ABC) transporter
J0916_RS12025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J0916_RS12030	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
J0916_RS12065	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J0916_RS12070	COG0456	acetyltransferase
J0916_RS12080	COG0802	atpase or kinase
J0916_RS12085	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J0916_RS12090	COG0438	transferase activity, transferring glycosyl groups
J0916_RS12105	COG0366	Alpha amylase catalytic
J0916_RS12115	COG1260	myo-inositol-1-phosphate synthase
J0916_RS12120	COG0667	Aldo Keto reductase
J0916_RS12135	COG0736	holo-[acyl-carrier-protein] synthase activity
J0916_RS12140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J0916_RS12145	COG1072	(Pantothenic acid kinase))
J0916_RS12155	COG1970	mechanosensitive ion channel activity
J0916_RS12160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J0916_RS12165	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J0916_RS12170	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J0916_RS12175	COG0101	tRNA pseudouridine synthase activity
J0916_RS12180	COG0203	ribosomal protein L17
J0916_RS12185	COG0202	RNA polymerase activity
J0916_RS12195	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J0916_RS12200	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J0916_RS12205	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J0916_RS12225	COG0395	ABC-type sugar transport system, permease component
J0916_RS12240	COG0024	Methionine aminopeptidase
J0916_RS12255	COG0200	Binds to the 23S rRNA
J0916_RS12265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J0916_RS12275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J0916_RS12280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J0916_RS12285	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J0916_RS12295	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J0916_RS12300	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J0916_RS12305	COG0255	Belongs to the universal ribosomal protein uL29 family
J0916_RS12310	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J0916_RS12315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J0916_RS12320	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J0916_RS12325	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J0916_RS12330	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J0916_RS12335	COG0089	rRNA binding
J0916_RS12340	COG0088	Forms part of the polypeptide exit tunnel
J0916_RS12345	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J0916_RS12350	COG0051	transcription antitermination factor activity, RNA binding
J0916_RS12360	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J0916_RS12365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J0916_RS12370	COG0049	tRNA binding
J0916_RS12375	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J0916_RS12380	COG1752	Esterase of the alpha-beta hydrolase superfamily
J0916_RS12385	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J0916_RS12390	COG0085	RNA polymerase activity
J0916_RS12395	COG0183	Belongs to the thiolase family
J0916_RS12400	COG0442	prolyl-tRNA aminoacylation
J0916_RS12405	COG0222	ribosome binding
J0916_RS12410	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J0916_RS12425	COG0081	regulation of translation
J0916_RS12430	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J0916_RS12435	COG0250	Participates in transcription elongation, termination and antitermination
J0916_RS12450	COG0436	Aminotransferase
J0916_RS12455	COG2197	response regulator
J0916_RS12500	COG3485	protocatechuate 3,4-dioxygenase
J0916_RS12505	COG0745	RESPONSE REGULATOR receiver
J0916_RS12510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J0916_RS12515	COG0456	acetyltransferase
J0916_RS12520	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J0916_RS12525	COG0406	alpha-ribazole phosphatase activity
J0916_RS12525	COG0494	nUDIX hydrolase
J0916_RS12535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J0916_RS12540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
J0916_RS12550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J0916_RS12565	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J0916_RS12570	COG2223	nitrite transmembrane transporter activity
J0916_RS12580	COG2030	dehydratase
J0916_RS12590	COG0477	Major facilitator Superfamily
J0916_RS12600	COG2301	Belongs to the HpcH HpaI aldolase family
J0916_RS12635	COG0477	Major facilitator Superfamily
J0916_RS12655	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
J0916_RS12665	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
J0916_RS12670	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_RS12675	COG0402	S-adenosylhomocysteine deaminase activity
J0916_RS12680	COG1652	LysM domain
J0916_RS12710	COG1012	belongs to the aldehyde dehydrogenase family
J0916_RS12715	COG0583	DNA-binding transcription factor activity
J0916_RS12720	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
J0916_RS12725	COG3655	Transcriptional regulator
J0916_RS12740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J0916_RS12745	COG2814	Major facilitator Superfamily
J0916_RS12770	COG1666	GTP binding
J0916_RS12785	COG4585	Histidine kinase
J0916_RS12790	COG0406	alpha-ribazole phosphatase activity
J0916_RS12800	COG0753	catalase activity
J0916_RS12845	COG1876	peptidase activity
J0916_RS12870	COG1648	precorrin-2 dehydrogenase activity
J0916_RS12870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J0916_RS12875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J0916_RS12920	COG0175	sulfate reduction
J0916_RS12925	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J0916_RS12935	COG0508	dehydrogenase complex catalyzes the overall conversion of
J0916_RS12940	COG0022	dehydrogenase e1 component
J0916_RS12940	COG0508	dehydrogenase complex catalyzes the overall conversion of
J0916_RS12945	COG0022	dehydrogenase e1 component
J0916_RS12945	COG0508	dehydrogenase complex catalyzes the overall conversion of
J0916_RS12950	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J0916_RS12955	COG0517	IMP dehydrogenase activity
J0916_RS12960	COG0477	Major facilitator Superfamily
J0916_RS12980	COG4152	abc transporter atp-binding protein
J0916_RS12985	COG2860	membrane
J0916_RS12995	COG0142	geranyltranstransferase activity
J0916_RS13015	COG1169	isochorismate synthase
J0916_RS13020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J0916_RS13040	COG4948	Mandelate Racemase Muconate Lactonizing
J0916_RS13070	COG0508	dehydrogenase complex catalyzes the overall conversion of
J0916_RS13110	COG2026	Addiction module toxin, RelE StbE family
J0916_RS13115	COG2161	toxin-antitoxin pair type II binding
J0916_RS13135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J0916_RS13145	COG1619	proteins homologs of microcin C7 resistance protein MccF
J0916_RS13170	COG0395	ABC-type sugar transport system, permease component
J0916_RS13180	COG3345	alpha-galactosidase
J0916_RS13210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J0916_RS13215	COG2151	metal-sulfur cluster biosynthetic enzyme
J0916_RS13220	COG3396	Phenylacetate-CoA oxygenase
J0916_RS13230	COG3396	Phenylacetate-CoA oxygenase
J0916_RS13255	COG1012	belongs to the aldehyde dehydrogenase family
J0916_RS13255	COG2030	dehydratase
J0916_RS13260	COG1250	3-hydroxyacyl-CoA dehydrogenase
J0916_RS13265	COG1024	Enoyl-CoA hydratase
J0916_RS13280	COG0076	glutamate decarboxylase activity
J0916_RS13320	COG1472	Belongs to the glycosyl hydrolase 3 family
J0916_RS13325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
J0916_RS13330	COG0280	phosphate acetyltransferase
J0916_RS13330	COG0857	belongs to the CobB CobQ family
J0916_RS13380	COG2365	Tyrosine phosphatase family
J0916_RS13405	COG0586	Pfam SNARE associated Golgi protein
J0916_RS13420	COG1131	(ABC) transporter
J0916_RS13425	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
J0916_RS13440	COG0745	RESPONSE REGULATOR receiver
J0916_RS13445	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
J0916_RS13450	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
J0916_RS13450	COG5479	isomerase activity
J0916_RS13490	COG2072	flavoprotein involved in K transport
J0916_RS13500	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
J0916_RS13535	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
J0916_RS13560	COG3550	peptidyl-serine autophosphorylation
J0916_RS13590	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
J0916_RS13625	COG4942	peptidase
J0916_RS13670	COG1309	transcriptional regulator
J0916_RS13705	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J0916_RS13715	COG0129	dihydroxy-acid dehydratase activity
J0916_RS13725	COG4555	ABC transporter
J0916_RS13745	COG2080	2 iron, 2 sulfur cluster binding
J0916_RS13750	COG0590	tRNA wobble adenosine to inosine editing
J0916_RS13765	COG1846	Transcriptional regulator
J0916_RS13780	COG0047	phosphoribosylformylglycinamidine synthase activity
J0916_RS13785	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J0916_RS13800	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
J0916_RS13810	COG1832	CoA-binding protein
J0916_RS13820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J0916_RS13825	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J0916_RS13835	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_RS13840	COG0477	Major facilitator Superfamily
J0916_RS13865	COG0191	fructose-bisphosphate aldolase activity
J0916_RS13880	COG0357	Ribosomal RNA small subunit methyltransferase G
J0916_RS13880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J0916_RS13890	COG1435	thymidine kinase activity
J0916_RS13895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J0916_RS13905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J0916_RS13920	COG3448	diguanylate cyclase activity
J0916_RS13920	COG4175	Glycine betaine
J0916_RS13995	COG2372	response to copper ion
J0916_RS14000	COG2252	PERMEase
J0916_RS14005	COG0010	Belongs to the arginase family
J0916_RS14010	COG2986	histidine ammonia-lyase
J0916_RS14050	COG4122	O-methyltransferase activity
J0916_RS14070	COG3387	PFAM Glycoside hydrolase 15-related
J0916_RS14075	COG0584	glycerophosphoryl diester phosphodiesterase
J0916_RS14080	COG2733	membrane
J0916_RS14115	COG0765	amino acid transport
J0916_RS14125	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J0916_RS14125	COG0519	Catalyzes the synthesis of GMP from XMP
J0916_RS14145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J0916_RS14145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J0916_RS14145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J0916_RS14150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J0916_RS14165	COG0300	oxidoreductase activity
J0916_RS14175	COG0351	phosphomethylpyrimidine kinase
J0916_RS14180	COG1335	isochorismatase
J0916_RS14205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J0916_RS14220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J0916_RS14235	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
J0916_RS14240	COG1194	a g-specific adenine glycosylase
J0916_RS14245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J0916_RS14245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J0916_RS14245	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
J0916_RS14255	COG2376	Dihydroxyacetone kinase
J0916_RS14260	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
J0916_RS14265	COG3548	integral membrane protein
J0916_RS14280	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J0916_RS14285	COG1609	Transcriptional regulator
J0916_RS14295	COG0477	Major facilitator Superfamily
J0916_RS14300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J0916_RS14305	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
J0916_RS14330	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J0916_RS14340	COG0302	gtp cyclohydrolase
J0916_RS14345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J0916_RS14355	COG0037	tRNA processing
J0916_RS14375	COG0561	phosphatase activity
J0916_RS14380	COG0477	Major facilitator Superfamily
J0916_RS14385	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J0916_RS14390	COG1597	lipid kinase activity
J0916_RS14410	COG3104	oligopeptide transport
J0916_RS14430	COG2233	PERMEase
J0916_RS14435	COG1929	Belongs to the glycerate kinase type-1 family
J0916_RS14445	COG0561	phosphatase activity
J0916_RS14530	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
J0916_RS14535	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J0916_RS14540	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J0916_RS14550	COG1987	bacterial-type flagellum assembly
J0916_RS14595	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
J0916_RS14605	COG1157	protein secretion by the type III secretion system
J0916_RS14615	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
J0916_RS14620	COG1766	The M ring may be actively involved in energy transduction
J0916_RS14625	COG1677	Flagellar hook-basal body complex protein FliE
J0916_RS14650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J0916_RS14665	COG1256	bacterial-type flagellum assembly
J0916_RS14665	COG4786	Flagellar basal body rod
J0916_RS14680	COG1063	alcohol dehydrogenase
J0916_RS14695	COG1556	Lactate utilization protein
J0916_RS14700	COG1139	Iron-sulfur cluster binding protein
J0916_RS14705	COG0247	lactate metabolic process
J0916_RS14710	COG1522	sequence-specific DNA binding
J0916_RS14720	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
J0916_RS14750	COG3853	Toxic anion resistance protein (TelA)
J0916_RS14790	COG0583	DNA-binding transcription factor activity
J0916_RS14820	COG1362	aminopeptidase activity
J0916_RS14825	COG2197	response regulator
J0916_RS14830	COG4585	Histidine kinase
J0916_RS14845	COG0738	Major facilitator superfamily
J0916_RS14850	COG0488	(ABC) transporter
J0916_RS14875	COG4585	Histidine kinase
J0916_RS14885	COG1136	(ABC) transporter
J0916_RS14905	COG0406	alpha-ribazole phosphatase activity
J0916_RS14910	COG0617	tRNA 3'-terminal CCA addition
J0916_RS14925	COG0492	ferredoxin-NADP+ reductase activity
J0916_RS14930	COG3118	belongs to the thioredoxin family
J0916_RS14980	COG1192	Involved in chromosome partitioning
J0916_RS14985	COG0357	Ribosomal RNA small subunit methyltransferase G
J0916_RS14995	COG0706	membrane insertase activity
J0916_RS15000	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J0916_RS15005	COG0594	ribonuclease P activity
J0916_RS15010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
J0916_RS15015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J0916_RS15020	COG0592	DNA-directed DNA polymerase activity
J0916_RS15025	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
J0916_RS15030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J0916_RS15035	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
J0916_RS15040	COG0187	DNA topoisomerase II activity
J0916_RS15045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J0916_RS15075	COG0705	Rhomboid family
J0916_RS15130	COG3764	Sortase (surface protein transpeptidase)
J0916_RS15140	COG0515	serine threonine protein kinase
J0916_RS15145	COG0515	serine threonine protein kinase
J0916_RS15170	COG1716	ATPase activity
J0916_RS15245	COG0360	Binds together with S18 to 16S ribosomal RNA
J0916_RS15255	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J0916_RS15260	COG0359	binds to the 23S rRNA
J0916_RS15265	COG0305	Participates in initiation and elongation during chromosome replication
J0916_RS15285	COG4821	SIS domain
J0916_RS15290	COG1653	transport
J0916_RS15295	COG1175	transmembrane transport
J0916_RS15300	COG0395	ABC-type sugar transport system, permease component
J0916_RS15325	COG1937	Protein conserved in bacteria
J0916_RS15335	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
J0916_RS15340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J0916_RS15355	COG0436	Aminotransferase
J0916_RS15365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J0916_RS15380	COG1950	PFAM Membrane protein of
J0916_RS15385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J0916_RS15395	COG0022	dehydrogenase e1 component
J0916_RS15400	COG0508	dehydrogenase complex catalyzes the overall conversion of
J0916_RS15405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J0916_RS15410	COG0686	Belongs to the AlaDH PNT family
J0916_RS15415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J0916_RS15425	COG0673	inositol 2-dehydrogenase activity
J0916_RS15470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J0916_RS15475	COG0247	lactate metabolic process
J0916_RS15475	COG0277	FAD linked oxidase domain protein
J0916_RS15510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J0916_RS15525	COG1174	glycine betaine transport
J0916_RS15535	COG1125	glycine betaine transport
J0916_RS15535	COG0517	IMP dehydrogenase activity
J0916_RS15545	COG0435	Glutathione S-transferase
J0916_RS15550	COG2764	glyoxalase bleomycin resistance protein dioxygenase
J0916_RS15560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J0916_RS15565	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J0916_RS15570	COG1120	ATPase activity
J0916_RS15585	COG1132	(ABC) transporter
J0916_RS15595	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J0916_RS15605	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J0916_RS15610	COG0776	regulation of translation
J0916_RS15625	COG0433	COG0433 Predicted ATPase
J0916_RS15635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J0916_RS15640	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
J0916_RS15655	COG3239	Fatty acid desaturase
J0916_RS15670	COG0475	glutathione-regulated potassium exporter activity
J0916_RS15680	COG0717	Belongs to the dCTP deaminase family
J0916_RS15700	COG0651	ATP synthesis coupled electron transport
J0916_RS15710	COG2212	antiporter activity
J0916_RS15715	COG1320	monovalent cation:proton antiporter activity
J0916_RS15725	COG4721	ABC-type cobalt transport system, permease component
J0916_RS15730	COG1122	ATPase activity
J0916_RS15740	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J0916_RS15775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J0916_RS15785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J0916_RS15795	COG1280	lysine exporter protein (LysE YggA)
J0916_RS15800	COG0640	Transcriptional regulator
J0916_RS15810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J0916_RS15815	COG2226	methyltransferase
J0916_RS15820	COG0443	Heat shock 70 kDa protein
J0916_RS15825	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J0916_RS15830	COG0484	heat shock protein binding
J0916_RS15835	COG0789	Transcriptional regulator
J0916_RS15840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J0916_RS15860	COG1140	nitrate reductase beta subunit
J0916_RS15870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J0916_RS15890	COG3304	Inner membrane component domain
J0916_RS15900	COG0667	Aldo Keto reductase
J0916_RS15920	COG2226	methyltransferase
J0916_RS15930	COG1476	TRANSCRIPTIONal
J0916_RS15935	COG0542	response to heat
J0916_RS15945	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J0916_RS15990	COG0151	Belongs to the GarS family
J0916_RS15995	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J0916_RS16005	COG2824	Alkylphosphonate utilization operon protein PhnA
J0916_RS16020	COG1408	metallophosphoesterase
J0916_RS16065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J0916_RS16125	COG1111	helicase
J0916_RS16125	COG1205	dead DEAH box helicase
J0916_RS16130	COG1054	Belongs to the UPF0176 family
J0916_RS16135	COG2890	protein-(glutamine-N5) methyltransferase activity
J0916_RS16140	COG1285	pathogenesis
J0916_RS16145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J0916_RS16145	COG1754	DNA topoisomerase type I activity
J0916_RS16150	COG0248	Ppx GppA phosphatase
J0916_RS16155	COG1082	Xylose isomerase domain protein TIM barrel
J0916_RS16160	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
J0916_RS16165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J0916_RS16175	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J0916_RS16180	COG0569	domain protein
J0916_RS16185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J0916_RS16190	COG0123	including yeast histone deacetylase and acetoin utilization protein
J0916_RS16200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J0916_RS16210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J0916_RS16215	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J0916_RS16240	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
J0916_RS16250	COG0406	alpha-ribazole phosphatase activity
J0916_RS16260	COG0785	Cytochrome C biogenesis protein
J0916_RS16270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J0916_RS16285	COG0488	(ABC) transporter
J0916_RS16295	COG2515	1-aminocyclopropane-1-carboxylate deaminase
J0916_RS16305	COG1132	(ABC) transporter
J0916_RS16310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J0916_RS16315	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
J0916_RS16335	COG0673	inositol 2-dehydrogenase activity
J0916_RS16350	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J0916_RS16365	COG1957	nucleoside hydrolase
J0916_RS16370	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_RS16375	COG1960	acyl-CoA dehydrogenase activity
J0916_RS16405	COG3971	2-oxopent-4-enoate hydratase activity
J0916_RS16415	COG1012	belongs to the aldehyde dehydrogenase family
J0916_RS16420	COG1802	Transcriptional regulator
J0916_RS16435	COG0477	Major facilitator Superfamily
J0916_RS16440	COG0583	DNA-binding transcription factor activity
J0916_RS16450	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
J0916_RS16460	COG0604	alcohol dehydrogenase
J0916_RS16475	COG0343	queuine tRNA-ribosyltransferase activity
J0916_RS16505	COG0626	cystathionine gamma-synthase activity
J0916_RS16525	COG0028	Belongs to the TPP enzyme family
J0916_RS16545	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
J0916_RS16555	COG0564	pseudouridine synthase activity
J0916_RS16560	COG2223	nitrite transmembrane transporter activity
J0916_RS16570	COG1201	RNA secondary structure unwinding
J0916_RS16590	COG2205	protein histidine kinase activity
J0916_RS16595	COG0745	RESPONSE REGULATOR receiver
J0916_RS16615	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
J0916_RS16645	COG2062	phosphohistidine phosphatase, SixA
J0916_RS16650	COG1511	domain protein
J0916_RS16655	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
J0916_RS16660	COG1940	carbohydrate kinase activity
J0916_RS16665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J0916_RS16670	COG4608	Belongs to the ABC transporter superfamily
J0916_RS16675	COG0444	Belongs to the ABC transporter superfamily
J0916_RS16690	COG2186	Transcriptional regulator
J0916_RS16705	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
J0916_RS16715	COG1959	2 iron, 2 sulfur cluster binding
J0916_RS16730	COG0514	ATP-dependent DNA helicase (RecQ)
J0916_RS16745	COG4948	Mandelate Racemase Muconate Lactonizing
J0916_RS16775	COG1172	Belongs to the binding-protein-dependent transport system permease family
J0916_RS16790	COG2186	Transcriptional regulator
J0916_RS16800	COG1505	serine-type exopeptidase activity
J0916_RS16810	COG1960	acyl-CoA dehydrogenase activity
J0916_RS16815	COG0045	succinate-CoA ligase (ADP-forming) activity
J0916_RS16820	COG1309	transcriptional regulator
J0916_RS16835	COG1012	belongs to the aldehyde dehydrogenase family
J0916_RS16840	COG0477	Major facilitator Superfamily
J0916_RS16845	COG2030	dehydratase
J0916_RS16855	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
J0916_RS16870	COG0604	alcohol dehydrogenase
J0916_RS16870	COG3321	synthase
J0916_RS16870	COG1028	Short-chain dehydrogenase reductase Sdr
J0916_RS16880	COG0110	maltose O-acetyltransferase activity
J0916_RS16885	COG1966	Carbon starvation protein
J0916_RS16915	COG3842	ATPase activity
J0916_RS16945	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J0916_RS16950	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J0916_RS16965	COG0384	phenazine biosynthesis protein PhzF
J0916_RS16975	COG0588	phosphoglycerate mutase activity
J0916_RS16980	COG0704	Plays a role in the regulation of phosphate uptake
J0916_RS16985	COG5002	protein histidine kinase activity
J0916_RS16990	COG0745	RESPONSE REGULATOR receiver
J0916_RS17000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J0916_RS17010	COG0215	cysteine-tRNA ligase activity
J0916_RS17015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J0916_RS17030	COG0366	Alpha amylase catalytic
J0916_RS17035	COG0366	Alpha amylase catalytic
J0916_RS17040	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J0916_RS17080	COG0366	Alpha amylase catalytic
J0916_RS17085	COG0277	FAD linked oxidase domain protein
J0916_RS17095	COG3842	ATPase activity
J0916_RS17185	COG2801	Transposase and inactivated derivatives
J0916_RS17215	COG2226	methyltransferase
J0916_RS17265	COG5002	protein histidine kinase activity
J0916_RS17360	COG0653	protein targeting