locus-tag	class	description
MB46_RS00035	COG1609	Transcriptional regulator
MB46_RS00040	COG0366	Alpha amylase catalytic
MB46_RS00050	COG1175	transmembrane transport
MB46_RS00055	COG3833	ABC-type maltose transport systems, permease component
MB46_RS00060	COG0366	Alpha amylase catalytic
MB46_RS00065	COG0277	FAD linked oxidase domain protein
MB46_RS00075	COG3842	ATPase activity
MB46_RS00080	COG0402	S-adenosylhomocysteine deaminase activity
MB46_RS00090	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
MB46_RS00140	COG1609	Transcriptional regulator
MB46_RS00150	COG0601	transmembrane transport
MB46_RS00155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MB46_RS00160	COG0444	Belongs to the ABC transporter superfamily
MB46_RS00165	COG4608	Belongs to the ABC transporter superfamily
MB46_RS00170	COG1621	beta-fructofuranosidase activity
MB46_RS00185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MB46_RS00210	COG1609	Transcriptional regulator
MB46_RS00225	COG4209	transmembrane transport
MB46_RS00230	COG0395	ABC-type sugar transport system, permease component
MB46_RS00235	COG1472	Belongs to the glycosyl hydrolase 3 family
MB46_RS00260	COG1609	Transcriptional regulator
MB46_RS00290	COG3962	Belongs to the TPP enzyme family
MB46_RS00305	COG0673	inositol 2-dehydrogenase activity
MB46_RS00310	COG1082	Xylose isomerase domain protein TIM barrel
MB46_RS00315	COG2814	Major facilitator Superfamily
MB46_RS00320	COG3718	enzyme involved in inositol metabolism
MB46_RS00325	COG2188	Transcriptional regulator
MB46_RS00340	COG0366	Alpha amylase catalytic
MB46_RS00360	COG1609	Transcriptional regulator
MB46_RS00365	COG1132	(ABC) transporter
MB46_RS00370	COG1132	(ABC) transporter
MB46_RS00395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MB46_RS00400	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MB46_RS00405	COG1120	ATPase activity
MB46_RS00430	COG1175	transmembrane transport
MB46_RS00440	COG1609	Transcriptional regulator
MB46_RS00445	COG1621	beta-fructofuranosidase activity
MB46_RS00450	COG1621	beta-fructofuranosidase activity
MB46_RS00460	COG2814	Major facilitator Superfamily
MB46_RS00475	COG0667	Aldo Keto reductase
MB46_RS00505	COG1012	belongs to the aldehyde dehydrogenase family
MB46_RS00510	COG0460	homoserine dehydrogenase
MB46_RS00515	COG0833	amino acid
MB46_RS00530	COG1414	Transcriptional regulator
MB46_RS00545	COG2040	homocysteine
MB46_RS00555	COG1902	pentaerythritol trinitrate reductase activity
MB46_RS00570	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MB46_RS00615	COG0803	Belongs to the bacterial solute-binding protein 9 family
MB46_RS00625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MB46_RS00630	COG1121	(ABC) transporter
MB46_RS00635	COG2132	Multicopper oxidase
MB46_RS00640	COG0659	secondary active sulfate transmembrane transporter activity
MB46_RS00665	COG1597	lipid kinase activity
MB46_RS00685	COG0477	Major facilitator Superfamily
MB46_RS00700	COG1132	(ABC) transporter
MB46_RS00705	COG1132	(ABC) transporter
MB46_RS00725	COG1940	carbohydrate kinase activity
MB46_RS00730	COG4533	DNA binding
MB46_RS00735	COG0601	transmembrane transport
MB46_RS00745	COG4172	Belongs to the ABC transporter superfamily
MB46_RS00750	COG4172	Belongs to the ABC transporter superfamily
MB46_RS00765	COG3711	transcriptional antiterminator
MB46_RS00775	COG1263	PTS System
MB46_RS00775	COG2190	(PTS) system
MB46_RS00775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MB46_RS00780	COG0561	phosphatase activity
MB46_RS00785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MB46_RS00815	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS00830	COG1012	belongs to the aldehyde dehydrogenase family
MB46_RS00840	COG1024	Enoyl-CoA hydratase
MB46_RS00850	COG0765	amino acid transport
MB46_RS00875	COG1136	(ABC) transporter
MB46_RS00880	COG0577	efflux transmembrane transporter activity
MB46_RS00900	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MB46_RS00920	COG0459	protein refolding
MB46_RS00925	COG0328	RNA-DNA hybrid ribonuclease activity
MB46_RS00935	COG2205	protein histidine kinase activity
MB46_RS00940	COG0745	RESPONSE REGULATOR receiver
MB46_RS00970	COG1278	Cold shock
MB46_RS00990	COG0739	heme binding
MB46_RS00995	COG1388	LysM domain
MB46_RS00995	COG3103	Sh3 type 3 domain protein
MB46_RS00995	COG0791	NLP P60 protein
MB46_RS01000	COG0746	molybdenum cofactor guanylyltransferase activity
MB46_RS01015	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MB46_RS01025	COG1126	abc transporter atp-binding protein
MB46_RS01030	COG0765	amino acid transport
MB46_RS01035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MB46_RS01040	COG1132	(ABC) transporter
MB46_RS01065	COG0483	inositol monophosphate 1-phosphatase activity
MB46_RS01080	COG0045	succinate-CoA ligase (ADP-forming) activity
MB46_RS01100	COG2814	Major facilitator Superfamily
MB46_RS01105	COG0656	L-ascorbic acid biosynthetic process
MB46_RS01110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MB46_RS01130	COG0508	dehydrogenase complex catalyzes the overall conversion of
MB46_RS01150	COG1396	sequence-specific DNA binding
MB46_RS01165	COG0028	Belongs to the TPP enzyme family
MB46_RS01170	COG0326	Molecular chaperone. Has ATPase activity
MB46_RS01210	COG0798	PFAM Bile acid sodium symporter
MB46_RS01215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MB46_RS01220	COG1902	pentaerythritol trinitrate reductase activity
MB46_RS01220	COG0446	pyridine nucleotide-disulphide oxidoreductase
MB46_RS01225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MB46_RS01235	COG1090	epimerase
MB46_RS01250	COG2186	Transcriptional regulator
MB46_RS01260	COG1027	Aspartate ammonia-lyase
MB46_RS01290	COG2376	Dihydroxyacetone kinase
MB46_RS01295	COG0698	ribose 5-phosphate isomerase
MB46_RS01300	COG1250	3-hydroxyacyl-CoA dehydrogenase
MB46_RS01305	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS01310	COG2271	Major facilitator Superfamily
MB46_RS01315	COG0149	triose-phosphate isomerase activity
MB46_RS01335	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MB46_RS01340	COG1185	polyribonucleotide nucleotidyltransferase activity
MB46_RS01375	COG1609	Transcriptional regulator
MB46_RS01380	COG4214	carbohydrate transport
MB46_RS01390	COG4213	ABC transporter substrate-binding protein
MB46_RS01395	COG1070	Carbohydrate kinase
MB46_RS01400	COG2115	Belongs to the xylose isomerase family
MB46_RS01405	COG1940	carbohydrate kinase activity
MB46_RS01430	COG2084	Dehydrogenase
MB46_RS01505	COG1349	DNA-binding transcription factor activity
MB46_RS01515	COG1175	transmembrane transport
MB46_RS01520	COG0395	ABC-type sugar transport system, permease component
MB46_RS01555	COG1960	acyl-CoA dehydrogenase activity
MB46_RS01570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MB46_RS01570	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MB46_RS01580	COG1278	Cold shock
MB46_RS01615	COG0477	Major facilitator Superfamily
MB46_RS01620	COG4948	Mandelate Racemase Muconate Lactonizing
MB46_RS01635	COG1619	proteins homologs of microcin C7 resistance protein MccF
MB46_RS01645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MB46_RS01655	COG4166	transmembrane transport
MB46_RS01670	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MB46_RS01675	COG1737	Transcriptional regulator
MB46_RS01680	COG1472	Belongs to the glycosyl hydrolase 3 family
MB46_RS01685	COG0138	bifunctional purine biosynthesis protein purh
MB46_RS01700	COG2838	Isocitrate dehydrogenase
MB46_RS01755	COG4214	carbohydrate transport
MB46_RS01785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MB46_RS01790	COG0531	amino acid
MB46_RS01800	COG0667	Aldo Keto reductase
MB46_RS01805	COG1914	H( )-stimulated, divalent metal cation uptake system
MB46_RS01810	COG4336	lyase activity
MB46_RS01820	COG4770	biotin carboxylase activity
MB46_RS01825	COG1984	allophanate hydrolase subunit 2
MB46_RS01830	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MB46_RS01840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MB46_RS01845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MB46_RS01870	COG2197	response regulator
MB46_RS01895	COG0180	Tryptophanyl-tRNA synthetase
MB46_RS01915	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MB46_RS01930	COG2009	succinate dehydrogenase
MB46_RS01935	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MB46_RS01935	COG0662	Cupin 2, conserved barrel domain protein
MB46_RS01940	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MB46_RS01940	COG1473	amidohydrolase
MB46_RS01945	COG1744	ABC transporter substrate-binding protein PnrA-like
MB46_RS01950	COG3845	ABC transporter
MB46_RS01955	COG4603	Belongs to the binding-protein-dependent transport system permease family
MB46_RS01960	COG1079	Belongs to the binding-protein-dependent transport system permease family
MB46_RS01975	COG0586	Pfam SNARE associated Golgi protein
MB46_RS01980	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MB46_RS02000	COG0148	phosphopyruvate hydratase activity
MB46_RS02020	COG1404	Belongs to the peptidase S8 family
MB46_RS02050	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MB46_RS02060	COG1349	DNA-binding transcription factor activity
MB46_RS02065	COG2017	converts alpha-aldose to the beta-anomer
MB46_RS02075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MB46_RS02085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MB46_RS02095	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MB46_RS02105	COG1331	Highly conserved protein containing a thioredoxin domain
MB46_RS02115	COG1136	(ABC) transporter
MB46_RS02115	COG0577	efflux transmembrane transporter activity
MB46_RS02120	COG1136	(ABC) transporter
MB46_RS02120	COG0577	efflux transmembrane transporter activity
MB46_RS02130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MB46_RS02135	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MB46_RS02160	COG4565	transcriptional regulatory protein
MB46_RS02165	COG3290	protein histidine kinase activity
MB46_RS02170	COG2851	Citrate transporter
MB46_RS02190	COG0114	fumarate hydratase activity
MB46_RS02195	COG0288	reversible hydration of carbon dioxide
MB46_RS02205	COG1494	fructose-1,6-bisphosphatase
MB46_RS02225	COG1316	TRANSCRIPTIONal
MB46_RS02230	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MB46_RS02280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MB46_RS02310	COG1376	ErfK ybiS ycfS ynhG family protein
MB46_RS02335	COG2894	cell division
MB46_RS02405	COG0714	Associated with various cellular activities
MB46_RS02410	COG0084	hydrolase, TatD family'
MB46_RS02415	COG3583	domain protein
MB46_RS02420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MB46_RS02425	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MB46_RS02430	COG0488	(ABC) transporter
MB46_RS02445	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MB46_RS02460	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MB46_RS02465	COG0193	aminoacyl-tRNA hydrolase activity
MB46_RS02495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MB46_RS02510	COG3979	chitinase
MB46_RS02520	COG1215	transferase activity, transferring glycosyl groups
MB46_RS02535	COG0463	Glycosyl transferase, family 2
MB46_RS02560	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MB46_RS02570	COG0489	protein tyrosine kinase activity
MB46_RS02575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MB46_RS02580	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MB46_RS02585	COG0297	glycogen (starch) synthase activity
MB46_RS02600	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MB46_RS02600	COG0662	Cupin 2, conserved barrel domain protein
MB46_RS02620	COG5002	protein histidine kinase activity
MB46_RS02625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MB46_RS02630	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MB46_RS02660	COG0745	RESPONSE REGULATOR receiver
MB46_RS02690	COG5002	protein histidine kinase activity
MB46_RS02725	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MB46_RS02740	COG1648	precorrin-2 dehydrogenase activity
MB46_RS02740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MB46_RS02745	COG2146	nitrite reductase [NAD(P)H] activity
MB46_RS02745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MB46_RS02755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MB46_RS02770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MB46_RS02775	COG0243	molybdopterin cofactor binding
MB46_RS02780	COG2223	nitrite transmembrane transporter activity
MB46_RS02785	COG0477	Major facilitator Superfamily
MB46_RS02790	COG4770	biotin carboxylase activity
MB46_RS02805	COG0424	maF-like protein
MB46_RS02830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MB46_RS02840	COG2409	Drug exporters of the RND superfamily
MB46_RS02865	COG0590	tRNA wobble adenosine to inosine editing
MB46_RS02870	COG1823	symporter activity
MB46_RS02885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MB46_RS02905	COG2197	response regulator
MB46_RS02920	COG0714	Associated with various cellular activities
MB46_RS02930	COG1305	Transglutaminase-like
MB46_RS02940	COG0631	protein serine/threonine phosphatase activity
MB46_RS02960	COG1674	ftsk spoiiie
MB46_RS02970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MB46_RS02985	COG0366	Alpha amylase catalytic
MB46_RS02990	COG0395	ABC-type sugar transport system, permease component
MB46_RS02995	COG1175	transmembrane transport
MB46_RS03005	COG1940	carbohydrate kinase activity
MB46_RS03025	COG0251	oxidation-reduction process
MB46_RS03035	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MB46_RS03040	COG0154	amidase activity
MB46_RS03045	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MB46_RS03065	COG4209	transmembrane transport
MB46_RS03070	COG0395	ABC-type sugar transport system, permease component
MB46_RS03080	COG1609	Transcriptional regulator
MB46_RS03085	COG0673	inositol 2-dehydrogenase activity
MB46_RS03090	COG0583	DNA-binding transcription factor activity
MB46_RS03095	COG1063	alcohol dehydrogenase
MB46_RS03110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MB46_RS03120	COG1228	amidohydrolase
MB46_RS03125	COG0366	Alpha amylase catalytic
MB46_RS03125	COG1470	cell adhesion involved in biofilm formation
MB46_RS03155	COG2837	iron assimilation
MB46_RS03170	COG0588	phosphoglycerate mutase activity
MB46_RS03190	COG2183	response to ionizing radiation
MB46_RS03195	COG2873	o-acetylhomoserine
MB46_RS03200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MB46_RS03230	COG2357	RelA SpoT domain protein
MB46_RS03235	COG0423	glycine-tRNA ligase activity
MB46_RS03255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MB46_RS03260	COG3424	synthase
MB46_RS03270	COG2239	Acts as a magnesium transporter
MB46_RS03280	COG1511	domain protein
MB46_RS03285	COG4133	protoheme IX ABC transporter activity
MB46_RS03305	COG0358	DNA primase activity
MB46_RS03340	COG0438	transferase activity, transferring glycosyl groups
MB46_RS03350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MB46_RS03350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MB46_RS03355	COG2814	Major facilitator Superfamily
MB46_RS03375	COG0297	glycogen (starch) synthase activity
MB46_RS03490	COG0052	Belongs to the universal ribosomal protein uS2 family
MB46_RS03495	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MB46_RS03500	COG0528	UMP kinase activity
MB46_RS03505	COG0233	cytoplasmic translational termination
MB46_RS03520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MB46_RS03530	COG3279	Response regulator of the LytR AlgR family
MB46_RS03535	COG3275	phosphorelay sensor kinase activity
MB46_RS03545	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MB46_RS03560	COG1522	sequence-specific DNA binding
MB46_RS03570	COG0022	dehydrogenase e1 component
MB46_RS03575	COG0508	dehydrogenase complex catalyzes the overall conversion of
MB46_RS03590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MB46_RS03600	COG1960	acyl-CoA dehydrogenase activity
MB46_RS03635	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MB46_RS03640	COG0750	zinc metalloprotease
MB46_RS03645	COG1609	Transcriptional regulator
MB46_RS03650	COG1621	beta-fructofuranosidase activity
MB46_RS03680	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MB46_RS03690	COG0446	pyridine nucleotide-disulphide oxidoreductase
MB46_RS03690	COG1902	pentaerythritol trinitrate reductase activity
MB46_RS03720	COG0442	prolyl-tRNA aminoacylation
MB46_RS03745	COG0779	Required for maturation of 30S ribosomal subunits
MB46_RS03755	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MB46_RS03760	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MB46_RS03780	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MB46_RS03805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MB46_RS03810	COG1185	polyribonucleotide nucleotidyltransferase activity
MB46_RS03815	COG0612	Peptidase, M16
MB46_RS03845	COG0315	cyclic pyranopterin monophosphate synthase activity
MB46_RS03850	COG0521	Mo-molybdopterin cofactor biosynthetic process
MB46_RS03860	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MB46_RS03870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MB46_RS03875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MB46_RS03880	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MB46_RS03885	COG1674	ftsk spoiiie
MB46_RS03895	COG1058	Belongs to the CinA family
MB46_RS03895	COG1546	Belongs to the CinA family
MB46_RS03910	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MB46_RS03915	COG2137	regulation of response to DNA damage stimulus
MB46_RS03925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MB46_RS03930	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MB46_RS03935	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MB46_RS03940	COG2813	Specifically methylates the guanine in position
MB46_RS03945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MB46_RS03955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MB46_RS03965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MB46_RS03970	COG0131	Imidazoleglycerol-phosphate dehydratase
MB46_RS03975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MB46_RS03980	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MB46_RS04000	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MB46_RS04005	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MB46_RS04010	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MB46_RS04015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MB46_RS04020	COG2814	Major facilitator Superfamily
MB46_RS04040	COG0318	PFAM AMP-dependent synthetase and ligase
MB46_RS04060	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MB46_RS04065	COG0072	phenylalanine-tRNA ligase activity
MB46_RS04065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MB46_RS04090	COG2267	carboxylic ester hydrolase activity
MB46_RS04095	COG2326	polyphosphate kinase activity
MB46_RS04115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MB46_RS04135	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MB46_RS04140	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MB46_RS04145	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MB46_RS04150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MB46_RS04155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MB46_RS04160	COG1438	arginine binding
MB46_RS04165	COG0137	argininosuccinate synthase activity
MB46_RS04170	COG0165	Argininosuccinate lyase
MB46_RS04190	COG2094	Belongs to the DNA glycosylase MPG family
MB46_RS04200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MB46_RS04210	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MB46_RS04245	COG0647	UMP catabolic process
MB46_RS04260	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MB46_RS04265	COG0497	DNA recombination
MB46_RS04270	COG0504	CTP synthase activity
MB46_RS04275	COG0494	nUDIX hydrolase
MB46_RS04295	COG1414	Transcriptional regulator
MB46_RS04310	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
MB46_RS04320	COG2610	gluconate transmembrane transporter activity
MB46_RS04330	COG1414	Transcriptional regulator
MB46_RS04335	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MB46_RS04340	COG0395	ABC-type sugar transport system, permease component
MB46_RS04370	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MB46_RS04375	COG2079	MmgE PrpD family protein
MB46_RS04390	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
MB46_RS04405	COG3486	L-lysine 6-monooxygenase (NADPH) activity
MB46_RS04415	COG4565	transcriptional regulatory protein
MB46_RS04420	COG3290	protein histidine kinase activity
MB46_RS04425	COG1301	dicarboxylic acid transport
MB46_RS04445	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MB46_RS04450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MB46_RS04465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MB46_RS04475	COG1160	GTP binding
MB46_RS04505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MB46_RS04530	COG0656	L-ascorbic acid biosynthetic process
MB46_RS04535	COG2390	Transcriptional regulator
MB46_RS04540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MB46_RS04545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MB46_RS04550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MB46_RS04555	COG0495	leucyl-tRNA aminoacylation
MB46_RS04560	COG1307	EDD domain protein, DegV family
MB46_RS04580	COG0268	Binds directly to 16S ribosomal RNA
MB46_RS04590	COG0481	GTPase activity
MB46_RS04595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MB46_RS04610	COG1420	regulation of RNA biosynthetic process
MB46_RS04615	COG0484	heat shock protein binding
MB46_RS04635	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MB46_RS04645	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MB46_RS04650	COG1316	TRANSCRIPTIONal
MB46_RS04655	COG3590	peptidase
MB46_RS04660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MB46_RS04665	COG1381	Involved in DNA repair and RecF pathway recombination
MB46_RS04670	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MB46_RS04685	COG0167	dihydroorotate dehydrogenase activity
MB46_RS04690	COG0667	Aldo Keto reductase
MB46_RS04710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MB46_RS04715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MB46_RS04730	COG2188	Transcriptional regulator
MB46_RS04735	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MB46_RS04740	COG0723	plastoquinol--plastocyanin reductase activity
MB46_RS04745	COG2010	Cytochrome c
MB46_RS04750	COG1845	cytochrome c oxidase, subunit III
MB46_RS04755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MB46_RS04785	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MB46_RS04800	COG2268	Band 7 protein
MB46_RS04805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MB46_RS04820	COG1643	Atp-dependent helicase
MB46_RS04825	COG0783	Belongs to the Dps family
MB46_RS04830	COG0009	L-threonylcarbamoyladenylate synthase
MB46_RS04835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MB46_RS04860	COG0673	inositol 2-dehydrogenase activity
MB46_RS04890	COG0659	secondary active sulfate transmembrane transporter activity
MB46_RS04900	COG0318	PFAM AMP-dependent synthetase and ligase
MB46_RS04915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MB46_RS04935	COG2050	protein possibly involved in aromatic compounds catabolism
MB46_RS04945	COG4552	Acetyltransferase involved in intracellular survival and related
MB46_RS04950	COG0539	negative regulation of cytoplasmic translation
MB46_RS04955	COG1739	Uncharacterized protein family UPF0029
MB46_RS04960	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MB46_RS04960	COG0237	dephospho-CoA kinase activity
MB46_RS04970	COG0556	nucleotide-excision repair
MB46_RS04975	COG4989	oxidoreductase activity
MB46_RS04995	COG4106	trans-aconitate 2-methyltransferase activity
MB46_RS05015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MB46_RS05035	COG0322	excinuclease ABC activity
MB46_RS05040	COG1660	Displays ATPase and GTPase activities
MB46_RS05050	COG1481	regulation of sporulation
MB46_RS05055	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MB46_RS05060	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MB46_RS05065	COG0126	phosphoglycerate kinase activity
MB46_RS05070	COG0149	triose-phosphate isomerase activity
MB46_RS05075	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MB46_RS05080	COG0363	glucosamine-6-phosphate deaminase activity
MB46_RS05095	COG0166	Belongs to the GPI family
MB46_RS05100	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MB46_RS05110	COG0109	protoheme IX farnesyltransferase activity
MB46_RS05125	COG1131	(ABC) transporter
MB46_RS05150	COG0396	ATPase activity
MB46_RS05155	COG2151	metal-sulfur cluster biosynthetic enzyme
MB46_RS05170	COG0183	Belongs to the thiolase family
MB46_RS05180	COG1122	ATPase activity
MB46_RS05185	COG1268	BioY protein
MB46_RS05190	COG0488	(ABC) transporter
MB46_RS05215	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS05220	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS05225	COG3830	Belongs to the UPF0237 family
MB46_RS05225	COG0560	Phosphoserine phosphatase
MB46_RS05230	COG1119	ATPase activity
MB46_RS05250	COG0254	rRNA binding
MB46_RS05270	COG2855	membrane
MB46_RS05280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MB46_RS05285	COG0297	glycogen (starch) synthase activity
MB46_RS05290	COG1403	HNH endonuclease
MB46_RS05315	COG0183	Belongs to the thiolase family
MB46_RS05320	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS05340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MB46_RS05360	COG0656	L-ascorbic acid biosynthetic process
MB46_RS05365	COG1968	undecaprenyl-diphosphatase activity
MB46_RS05370	COG0215	cysteine-tRNA ligase activity
MB46_RS05380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MB46_RS05395	COG1222	aaa ATPase
MB46_RS05400	COG4122	O-methyltransferase activity
MB46_RS05410	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MB46_RS05415	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MB46_RS05420	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MB46_RS05445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MB46_RS05450	COG0805	protein transport
MB46_RS05455	COG4581	dead DEAH box helicase
MB46_RS05460	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MB46_RS05465	COG1216	Glycosyl transferase, family 2
MB46_RS05490	COG2364	Membrane
MB46_RS05495	COG2226	methyltransferase
MB46_RS05500	COG0242	peptide deformylase activity
MB46_RS05520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MB46_RS05525	COG0596	Alpha beta hydrolase
MB46_RS05580	COG2329	Antibiotic biosynthesis monooxygenase
MB46_RS05595	COG1725	Transcriptional regulator
MB46_RS05640	COG0135	phosphoribosylanthranilate isomerase activity
MB46_RS05645	COG1940	carbohydrate kinase activity
MB46_RS05665	COG3119	arylsulfatase activity
MB46_RS05695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MB46_RS05700	COG1121	(ABC) transporter
MB46_RS05715	COG2814	Major facilitator Superfamily
MB46_RS05720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MB46_RS05740	COG1349	DNA-binding transcription factor activity
MB46_RS05760	COG1489	DNA binding
MB46_RS05785	COG1063	alcohol dehydrogenase
MB46_RS05790	COG3639	organic phosphonate transmembrane transporter activity
MB46_RS05795	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MB46_RS05800	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
MB46_RS05815	COG0833	amino acid
MB46_RS05825	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
MB46_RS05830	COG0829	nickel cation binding
MB46_RS05835	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MB46_RS05840	COG0830	nickel cation binding
MB46_RS05845	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
MB46_RS05850	COG0804	urea catabolic process
MB46_RS05855	COG0832	Belongs to the urease beta subunit family
MB46_RS05860	COG0831	urea catabolic process
MB46_RS05870	COG1902	pentaerythritol trinitrate reductase activity
MB46_RS05935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MB46_RS05945	COG1832	CoA-binding protein
MB46_RS05960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MB46_RS05985	COG0395	ABC-type sugar transport system, permease component
MB46_RS05990	COG4209	transmembrane transport
MB46_RS06000	COG1609	Transcriptional regulator
MB46_RS06005	COG1609	Transcriptional regulator
MB46_RS06010	COG1653	transport
MB46_RS06015	COG1175	transmembrane transport
MB46_RS06035	COG0673	inositol 2-dehydrogenase activity
MB46_RS06040	COG0277	FAD linked oxidase domain protein
MB46_RS06045	COG1846	Transcriptional regulator
MB46_RS06050	COG1764	response to oxidative stress
MB46_RS06060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MB46_RS06065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MB46_RS06070	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MB46_RS06075	COG1120	ATPase activity
MB46_RS06085	COG2186	Transcriptional regulator
MB46_RS06090	COG0747	negative chemotaxis
MB46_RS06095	COG0601	transmembrane transport
MB46_RS06100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MB46_RS06105	COG4172	Belongs to the ABC transporter superfamily
MB46_RS06115	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS06120	COG1012	belongs to the aldehyde dehydrogenase family
MB46_RS06125	COG0473	3-isopropylmalate dehydrogenase activity
MB46_RS06150	COG0667	Aldo Keto reductase
MB46_RS06175	COG2814	Major facilitator Superfamily
MB46_RS06195	COG1854	S-ribosylhomocysteine lyase activity
MB46_RS06200	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MB46_RS06205	COG1609	Transcriptional regulator
MB46_RS06210	COG1653	transport
MB46_RS06215	COG1175	transmembrane transport
MB46_RS06220	COG0395	ABC-type sugar transport system, permease component
MB46_RS06270	COG1522	sequence-specific DNA binding
MB46_RS06275	COG0686	Belongs to the AlaDH PNT family
MB46_RS06295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MB46_RS06320	COG4172	Belongs to the ABC transporter superfamily
MB46_RS06325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MB46_RS06330	COG0601	transmembrane transport
MB46_RS06360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MB46_RS06395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MB46_RS06395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MB46_RS06420	COG0667	Aldo Keto reductase
MB46_RS06425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MB46_RS06430	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MB46_RS06430	COG5479	isomerase activity
MB46_RS06460	COG0747	negative chemotaxis
MB46_RS06475	COG3142	Participates in the control of copper homeostasis
MB46_RS06480	COG3903	Transcriptional regulator
MB46_RS06480	COG3629	intracellular signal transduction
MB46_RS06485	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS06490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MB46_RS06495	COG0251	oxidation-reduction process
MB46_RS06500	COG0477	Major facilitator Superfamily
MB46_RS06510	COG0477	Major facilitator Superfamily
MB46_RS06515	COG0028	Belongs to the TPP enzyme family
MB46_RS06520	COG1012	belongs to the aldehyde dehydrogenase family
MB46_RS06525	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MB46_RS06530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MB46_RS06535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MB46_RS06545	COG1621	beta-fructofuranosidase activity
MB46_RS06550	COG1653	transport
MB46_RS06555	COG0395	ABC-type sugar transport system, permease component
MB46_RS06560	COG4209	transmembrane transport
MB46_RS06565	COG1609	Transcriptional regulator
MB46_RS06590	COG0438	transferase activity, transferring glycosyl groups
MB46_RS06595	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MB46_RS06610	COG0726	polysaccharide deacetylase
MB46_RS06645	COG1295	ribonuclease BN
MB46_RS06660	COG2378	regulation of single-species biofilm formation
MB46_RS06710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MB46_RS06770	COG1063	alcohol dehydrogenase
MB46_RS06780	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS06810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MB46_RS06815	COG2814	Major facilitator Superfamily
MB46_RS06830	COG0179	Fumarylacetoacetate (FAA) hydrolase
MB46_RS06840	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MB46_RS06845	COG1733	regulation of RNA biosynthetic process
MB46_RS06850	COG0702	epimerase
MB46_RS06870	COG3483	tryptophan 2,3-dioxygenase activity
MB46_RS06895	COG2011	ABC-type metal ion transport system permease component
MB46_RS06900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MB46_RS06935	COG0583	DNA-binding transcription factor activity
MB46_RS06945	COG0454	-acetyltransferase
MB46_RS06950	COG2197	response regulator
MB46_RS06960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MB46_RS07020	COG0583	DNA-binding transcription factor activity
MB46_RS07025	COG0477	Major facilitator Superfamily
MB46_RS07050	COG1012	belongs to the aldehyde dehydrogenase family
MB46_RS07060	COG1414	Transcriptional regulator
MB46_RS07065	COG0179	Fumarylacetoacetate (FAA) hydrolase
MB46_RS07075	COG1012	belongs to the aldehyde dehydrogenase family
MB46_RS07085	COG3971	2-oxopent-4-enoate hydratase activity
MB46_RS07110	COG2315	Protein conserved in bacteria
MB46_RS07120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MB46_RS07135	COG4585	Histidine kinase
MB46_RS07140	COG2197	response regulator
MB46_RS07190	COG2814	Major facilitator Superfamily
MB46_RS07290	COG3237	CsbD-like
MB46_RS07330	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS07330	COG0604	alcohol dehydrogenase
MB46_RS07330	COG3321	synthase
MB46_RS07340	COG0471	metal ion transport
MB46_RS07340	COG0490	domain, Protein
MB46_RS07345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MB46_RS07350	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MB46_RS07455	COG0730	response to heat
MB46_RS07460	COG2188	Transcriptional regulator
MB46_RS07505	COG2814	Major facilitator Superfamily
MB46_RS07510	COG2814	Major facilitator Superfamily
MB46_RS07515	COG0640	Transcriptional regulator
MB46_RS07525	COG3547	Transposase (IS116 IS110 IS902 family)
MB46_RS07530	COG2801	Transposase and inactivated derivatives
MB46_RS07530	COG3415	Transposase
MB46_RS07535	COG0471	metal ion transport
MB46_RS07535	COG0490	domain, Protein
MB46_RS07540	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MB46_RS07545	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MB46_RS07560	COG2235	arginine
MB46_RS07580	COG2963	transposase activity
MB46_RS07585	COG2801	Transposase and inactivated derivatives
MB46_RS07620	COG0070	glutamate synthase
MB46_RS07620	COG0067	glutamate synthase
MB46_RS07620	COG0069	glutamate synthase activity
MB46_RS07625	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MB46_RS07630	COG0159	tryptophan synthase activity
MB46_RS07635	COG0133	tryptophan synthase activity
MB46_RS07640	COG0134	indole-3-glycerol-phosphate synthase activity
MB46_RS07660	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MB46_RS07670	COG0107	imidazoleglycerol-phosphate synthase activity
MB46_RS07675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MB46_RS07680	COG0140	phosphoribosyl-ATP diphosphatase activity
MB46_RS07685	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MB46_RS07690	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MB46_RS07695	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MB46_RS07695	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MB46_RS07715	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MB46_RS07725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MB46_RS07730	COG0242	peptide deformylase activity
MB46_RS07785	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MB46_RS07800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MB46_RS07815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MB46_RS07840	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MB46_RS07845	COG0183	Belongs to the thiolase family
MB46_RS07850	COG1250	3-hydroxyacyl-CoA dehydrogenase
MB46_RS07850	COG1024	Enoyl-CoA hydratase
MB46_RS07860	COG0667	Aldo Keto reductase
MB46_RS07875	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MB46_RS07880	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MB46_RS07890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MB46_RS07895	COG0531	amino acid
MB46_RS07900	COG0569	domain protein
MB46_RS07925	COG0756	dUTP diphosphatase activity
MB46_RS07960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MB46_RS07980	COG4988	ABC transporter
MB46_RS07985	COG1294	oxidase, subunit
MB46_RS07990	COG1271	oxidase subunit
MB46_RS08020	COG2197	response regulator
MB46_RS08025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MB46_RS08045	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MB46_RS08050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MB46_RS08055	COG0508	dehydrogenase complex catalyzes the overall conversion of
MB46_RS08075	COG0321	lipoyl(octanoyl) transferase activity
MB46_RS08080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MB46_RS08115	COG2066	Belongs to the glutaminase family
MB46_RS08120	COG1126	abc transporter atp-binding protein
MB46_RS08125	COG0765	amino acid transport
MB46_RS08135	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MB46_RS08140	COG0174	glutamine synthetase
MB46_RS08145	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MB46_RS08165	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS08170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MB46_RS08175	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MB46_RS08185	COG0587	DNA-directed DNA polymerase activity
MB46_RS08195	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MB46_RS08200	COG3599	regulation of cell shape
MB46_RS08210	COG1799	cell septum assembly
MB46_RS08215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MB46_RS08220	COG1496	oxidoreductase activity
MB46_RS08225	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MB46_RS08230	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MB46_RS08235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MB46_RS08240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MB46_RS08250	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MB46_RS08255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MB46_RS08265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MB46_RS08270	COG0768	penicillin binding
MB46_RS08280	COG0275	rRNA processing
MB46_RS08285	COG2001	Belongs to the MraZ family
MB46_RS08295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MB46_RS08305	COG0142	geranyltranstransferase activity
MB46_RS08315	COG1388	LysM domain
MB46_RS08315	COG3942	CHAP domain
MB46_RS08320	COG2815	serine threonine protein kinase
MB46_RS08320	COG0515	serine threonine protein kinase
MB46_RS08325	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MB46_RS08345	COG1940	carbohydrate kinase activity
MB46_RS08355	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MB46_RS08360	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MB46_RS08360	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MB46_RS08385	COG1716	ATPase activity
MB46_RS08390	COG0509	glycine decarboxylation via glycine cleavage system
MB46_RS08405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MB46_RS08410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MB46_RS08415	COG1960	acyl-CoA dehydrogenase activity
MB46_RS08440	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MB46_RS08445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MB46_RS08455	COG1758	RNA polymerase activity
MB46_RS08460	COG0194	GDP metabolic process
MB46_RS08465	COG0194	GDP metabolic process
MB46_RS08470	COG0284	orotidine-5'-phosphate decarboxylase activity
MB46_RS08475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MB46_RS08480	COG0505	Belongs to the CarA family
MB46_RS08490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MB46_RS08495	COG0540	Belongs to the ATCase OTCase family
MB46_RS08500	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MB46_RS08510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MB46_RS08515	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MB46_RS08525	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MB46_RS08530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MB46_RS08535	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MB46_RS08550	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MB46_RS08555	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MB46_RS08570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MB46_RS08585	COG1695	Transcriptional regulator
MB46_RS08595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MB46_RS08605	COG1120	ATPase activity
MB46_RS08620	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MB46_RS08625	COG0124	histidyl-tRNA synthetase
MB46_RS08635	COG1196	nuclear chromosome segregation
MB46_RS08645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MB46_RS08650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MB46_RS08655	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MB46_RS08665	COG2255	four-way junction helicase activity
MB46_RS08670	COG0632	four-way junction helicase activity
MB46_RS08675	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MB46_RS08680	COG0217	transcriptional regulatory protein
MB46_RS08685	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MB46_RS08690	COG0367	asparagine synthase
MB46_RS08695	COG0339	signal peptide processing
MB46_RS08700	COG0456	acetyltransferase
MB46_RS08705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MB46_RS08710	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MB46_RS08715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MB46_RS08725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MB46_RS08730	COG0587	DNA-directed DNA polymerase activity
MB46_RS08740	COG0456	acetyltransferase
MB46_RS08750	COG2135	peptidase activity
MB46_RS08785	COG0318	PFAM AMP-dependent synthetase and ligase
MB46_RS08795	COG4682	membrane
MB46_RS08800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MB46_RS08805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MB46_RS08810	COG1780	Probably involved in ribonucleotide reductase function
MB46_RS08825	COG3226	Transcriptional regulator
MB46_RS08830	COG0110	maltose O-acetyltransferase activity
MB46_RS08835	COG0583	DNA-binding transcription factor activity
MB46_RS08840	COG1012	belongs to the aldehyde dehydrogenase family
MB46_RS08850	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MB46_RS08880	COG0714	Associated with various cellular activities
MB46_RS08895	COG2813	Specifically methylates the guanine in position
MB46_RS08900	COG3012	SEC-C Motif Domain Protein
MB46_RS08905	COG2188	Transcriptional regulator
MB46_RS08925	COG0799	negative regulation of ribosome biogenesis
MB46_RS08935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MB46_RS08945	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MB46_RS08950	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MB46_RS08955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MB46_RS08960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MB46_RS08965	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MB46_RS08970	COG0351	phosphomethylpyrimidine kinase
MB46_RS08970	COG0352	thiamine-phosphate diphosphorylase activity
MB46_RS08970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MB46_RS08975	COG1530	ribonuclease E activity
MB46_RS08985	COG0105	UTP biosynthetic process
MB46_RS08995	COG0285	dihydrofolate synthase activity
MB46_RS09000	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MB46_RS09010	COG3189	MarR family transcriptional regulator
MB46_RS09020	COG0525	valine-tRNA ligase activity
MB46_RS09030	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MB46_RS09035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MB46_RS09035	COG0438	transferase activity, transferring glycosyl groups
MB46_RS09040	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MB46_RS09045	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MB46_RS09050	COG0740	serine-type endopeptidase activity
MB46_RS09055	COG0740	serine-type endopeptidase activity
MB46_RS09060	COG0544	peptidyl-prolyl cis-trans isomerase activity
MB46_RS09070	COG3415	Transposase
MB46_RS09070	COG2801	Transposase and inactivated derivatives
MB46_RS09085	COG0698	ribose 5-phosphate isomerase
MB46_RS09110	COG0668	transmembrane transport
MB46_RS09115	COG2346	COG2346, Truncated hemoglobins
MB46_RS09130	COG1946	Acyl-CoA thioesterase
MB46_RS09150	COG0629	single-stranded DNA binding
MB46_RS09180	COG0604	alcohol dehydrogenase
MB46_RS09180	COG3321	synthase
MB46_RS09185	COG2267	carboxylic ester hydrolase activity
MB46_RS09200	COG3384	dioxygenase
MB46_RS09210	COG3540	Alkaline phosphatase
MB46_RS09245	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MB46_RS09255	COG0156	8-amino-7-oxononanoate synthase activity
MB46_RS09260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MB46_RS09265	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MB46_RS09300	COG2890	protein-(glutamine-N5) methyltransferase activity
MB46_RS09345	COG0477	Major facilitator Superfamily
MB46_RS09355	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MB46_RS09370	COG3022	response to hydroperoxide
MB46_RS09380	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MB46_RS09385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MB46_RS09395	COG1045	serine acetyltransferase
MB46_RS09400	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MB46_RS09405	COG1063	alcohol dehydrogenase
MB46_RS09410	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS09415	COG2084	Dehydrogenase
MB46_RS09425	COG0477	Major facilitator Superfamily
MB46_RS09440	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MB46_RS09465	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MB46_RS09480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MB46_RS09485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MB46_RS09490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MB46_RS09500	COG4974	Belongs to the 'phage' integrase family
MB46_RS09515	COG0792	nuclease activity
MB46_RS09525	COG1012	belongs to the aldehyde dehydrogenase family
MB46_RS09530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MB46_RS09535	COG2910	NAD(P)H-binding
MB46_RS09540	COG1733	regulation of RNA biosynthetic process
MB46_RS09550	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MB46_RS09555	COG0681	Belongs to the peptidase S26 family
MB46_RS09560	COG0681	Belongs to the peptidase S26 family
MB46_RS09565	COG0335	large ribosomal subunit rRNA binding
MB46_RS09570	COG0336	Belongs to the RNA methyltransferase TrmD family
MB46_RS09575	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MB46_RS09580	COG1837	Belongs to the UPF0109 family
MB46_RS09585	COG0228	four-way junction DNA binding
MB46_RS09595	COG2514	catechol 2,3-dioxygenase activity
MB46_RS09620	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MB46_RS09670	COG0477	Major facilitator Superfamily
MB46_RS09675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MB46_RS09685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MB46_RS09695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MB46_RS09715	COG0765	amino acid transport
MB46_RS09735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MB46_RS09740	COG0318	PFAM AMP-dependent synthetase and ligase
MB46_RS09745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MB46_RS09755	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MB46_RS09760	COG0571	ribonuclease III activity
MB46_RS09765	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MB46_RS09775	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MB46_RS09790	COG0673	inositol 2-dehydrogenase activity
MB46_RS09800	COG2268	Band 7 protein
MB46_RS09810	COG0742	ribosomal rna small subunit methyltransferase
MB46_RS09845	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS09850	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MB46_RS09855	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS09870	COG1120	ATPase activity
MB46_RS09885	COG2267	carboxylic ester hydrolase activity
MB46_RS09900	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MB46_RS09915	COG1181	Belongs to the D-alanine--D-alanine ligase family
MB46_RS09920	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MB46_RS09930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MB46_RS09935	COG0066	3-isopropylmalate dehydratase activity
MB46_RS09940	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MB46_RS09945	COG1414	Transcriptional regulator
MB46_RS09975	COG0546	phosphoglycolate phosphatase activity
MB46_RS09980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MB46_RS10000	COG1113	amino acid transport
MB46_RS10005	COG2197	response regulator
MB46_RS10010	COG4585	Histidine kinase
MB46_RS10040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MB46_RS10050	COG2814	Major facilitator Superfamily
MB46_RS10055	COG0473	3-isopropylmalate dehydrogenase activity
MB46_RS10060	COG0415	Belongs to the DNA photolyase family
MB46_RS10100	COG0702	epimerase
MB46_RS10105	COG4585	Histidine kinase
MB46_RS10110	COG2197	response regulator
MB46_RS10120	COG1175	transmembrane transport
MB46_RS10125	COG1653	transport
MB46_RS10135	COG2186	Transcriptional regulator
MB46_RS10145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MB46_RS10150	COG1136	(ABC) transporter
MB46_RS10150	COG0577	efflux transmembrane transporter activity
MB46_RS10195	COG0395	ABC-type sugar transport system, permease component
MB46_RS10210	COG1940	carbohydrate kinase activity
MB46_RS10215	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MB46_RS10220	COG0440	acetolactate synthase activity
MB46_RS10230	COG0129	dihydroxy-acid dehydratase activity
MB46_RS10245	COG0582	viral genome integration into host DNA
MB46_RS10300	COG1475	DNA binding
MB46_RS10485	COG0747	negative chemotaxis
MB46_RS10490	COG0579	oxidoreductase
MB46_RS10495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MB46_RS10500	COG2814	Major facilitator Superfamily
MB46_RS10505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MB46_RS10510	COG1846	Transcriptional regulator
MB46_RS10515	COG1403	HNH endonuclease
MB46_RS10530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MB46_RS10545	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MB46_RS10555	COG3639	organic phosphonate transmembrane transporter activity
MB46_RS10560	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MB46_RS10570	COG0179	Fumarylacetoacetate (FAA) hydrolase
MB46_RS10585	COG1104	cysteine desulfurase activity
MB46_RS10595	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MB46_RS10600	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MB46_RS10620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MB46_RS10625	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MB46_RS10630	COG1120	ATPase activity
MB46_RS10635	COG1113	amino acid transport
MB46_RS10640	COG2267	carboxylic ester hydrolase activity
MB46_RS10650	COG0419	ATPase involved in DNA repair
MB46_RS10655	COG0420	3'-5' exonuclease activity
MB46_RS10660	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MB46_RS10670	COG2149	membrane
MB46_RS10700	COG1131	(ABC) transporter
MB46_RS10715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MB46_RS10720	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MB46_RS10730	COG1234	tRNA 3'-trailer cleavage
MB46_RS10735	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MB46_RS10745	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MB46_RS10750	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MB46_RS10755	COG1335	isochorismatase
MB46_RS10770	COG0363	glucosamine-6-phosphate deaminase activity
MB46_RS10785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MB46_RS10795	COG0628	permease
MB46_RS10805	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MB46_RS10810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MB46_RS10820	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MB46_RS10825	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MB46_RS10835	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MB46_RS10840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MB46_RS10845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MB46_RS10850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MB46_RS10855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MB46_RS10860	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MB46_RS10865	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MB46_RS10870	COG0356	it plays a direct role in the translocation of protons across the membrane
MB46_RS10885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MB46_RS10890	COG1086	Polysaccharide biosynthesis protein
MB46_RS10900	COG1216	Glycosyl transferase, family 2
MB46_RS10920	COG2890	protein-(glutamine-N5) methyltransferase activity
MB46_RS10925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MB46_RS10935	COG0083	homoserine kinase activity
MB46_RS10940	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MB46_RS10945	COG0460	homoserine dehydrogenase
MB46_RS10950	COG0019	diaminopimelate decarboxylase activity
MB46_RS10955	COG0018	arginyl-trna synthetase
MB46_RS10975	COG2723	6-phospho-beta-galactosidase activity
MB46_RS10990	COG0456	acetyltransferase
MB46_RS10995	COG0697	spore germination
MB46_RS11000	COG1846	Transcriptional regulator
MB46_RS11010	COG1643	Atp-dependent helicase
MB46_RS11020	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS11030	COG0537	adenosine 5'-monophosphoramidase activity
MB46_RS11035	COG1064	alcohol dehydrogenase
MB46_RS11045	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MB46_RS11075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MB46_RS11080	COG1120	ATPase activity
MB46_RS11095	COG1253	flavin adenine dinucleotide binding
MB46_RS11110	COG3265	gluconokinase activity
MB46_RS11120	COG3265	gluconokinase activity
MB46_RS11125	COG4948	Mandelate Racemase Muconate Lactonizing
MB46_RS11135	COG0246	Mannitol dehydrogenase
MB46_RS11140	COG1904	glucuronate isomerase
MB46_RS11145	COG1609	Transcriptional regulator
MB46_RS11150	COG0673	inositol 2-dehydrogenase activity
MB46_RS11165	COG0444	Belongs to the ABC transporter superfamily
MB46_RS11180	COG0673	inositol 2-dehydrogenase activity
MB46_RS11190	COG1609	Transcriptional regulator
MB46_RS11200	COG0508	dehydrogenase complex catalyzes the overall conversion of
MB46_RS11200	COG0567	Dehydrogenase, E1 component
MB46_RS11230	COG1595	DNA-templated transcription, initiation
MB46_RS11240	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MB46_RS11250	COG0483	inositol monophosphate 1-phosphatase activity
MB46_RS11255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MB46_RS11260	COG2226	methyltransferase
MB46_RS11270	COG1321	iron dependent repressor
MB46_RS11280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MB46_RS11310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MB46_RS11315	COG0739	heme binding
MB46_RS11320	COG2177	Part of the ABC transporter FtsEX involved in
MB46_RS11325	COG2884	Cell division ATP-binding protein ftsE
MB46_RS11335	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MB46_RS11375	COG2755	lipolytic protein G-D-S-L family
MB46_RS11375	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MB46_RS11390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MB46_RS11400	COG1088	dTDP-glucose 4,6-dehydratase activity
MB46_RS11410	COG0463	Glycosyl transferase, family 2
MB46_RS11425	COG1216	Glycosyl transferase, family 2
MB46_RS11455	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MB46_RS11510	COG0673	inositol 2-dehydrogenase activity
MB46_RS11530	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MB46_RS11550	COG1216	Glycosyl transferase, family 2
MB46_RS11580	COG2902	Dehydrogenase
MB46_RS11615	COG0653	protein targeting
MB46_RS11620	COG3214	Protein conserved in bacteria
MB46_RS11625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MB46_RS11630	COG1040	competence protein
MB46_RS11635	COG5401	PFAM Sporulation and spore germination
MB46_RS11640	COG5002	protein histidine kinase activity
MB46_RS11645	COG0745	RESPONSE REGULATOR receiver
MB46_RS11665	COG0714	Associated with various cellular activities
MB46_RS11690	COG4172	Belongs to the ABC transporter superfamily
MB46_RS11695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MB46_RS11700	COG0601	transmembrane transport
MB46_RS11705	COG0747	negative chemotaxis
MB46_RS11715	COG0482	sulfurtransferase activity
MB46_RS11725	COG1404	Belongs to the peptidase S8 family
MB46_RS11735	COG0302	gtp cyclohydrolase
MB46_RS11745	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MB46_RS11765	COG0484	heat shock protein binding
MB46_RS11770	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MB46_RS11775	COG2226	methyltransferase
MB46_RS11780	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MB46_RS11790	COG0577	efflux transmembrane transporter activity
MB46_RS11790	COG1136	(ABC) transporter
MB46_RS11800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MB46_RS11810	COG1842	Phage shock protein A
MB46_RS11815	COG0656	L-ascorbic acid biosynthetic process
MB46_RS11825	COG0667	Aldo Keto reductase
MB46_RS11855	COG0596	Alpha beta hydrolase
MB46_RS11875	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MB46_RS11880	COG1960	acyl-CoA dehydrogenase activity
MB46_RS11890	COG1846	Transcriptional regulator
MB46_RS11895	COG1024	Enoyl-CoA hydratase
MB46_RS11900	COG1024	Enoyl-CoA hydratase
MB46_RS11900	COG1250	3-hydroxyacyl-CoA dehydrogenase
MB46_RS11905	COG0183	Belongs to the thiolase family
MB46_RS11910	COG0628	permease
MB46_RS11915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MB46_RS11920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MB46_RS11935	COG0471	metal ion transport
MB46_RS11935	COG0490	domain, Protein
MB46_RS11945	COG1615	UPF0182 protein
MB46_RS11950	COG3480	Lon protease (S16) C-terminal proteolytic domain
MB46_RS11985	COG0210	DNA helicase
MB46_RS12005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MB46_RS12010	COG0765	amino acid transport
MB46_RS12015	COG1126	abc transporter atp-binding protein
MB46_RS12020	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MB46_RS12035	COG0181	hydroxymethylbilane synthase activity
MB46_RS12040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MB46_RS12045	COG3253	May function as heme-dependent peroxidase
MB46_RS12055	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MB46_RS12060	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MB46_RS12075	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MB46_RS12080	COG2011	ABC-type metal ion transport system permease component
MB46_RS12085	COG1464	Belongs to the NlpA lipoprotein family
MB46_RS12110	COG2022	thiamine diphosphate biosynthetic process
MB46_RS12120	COG2022	thiamine diphosphate biosynthetic process
MB46_RS12120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MB46_RS12125	COG0352	thiamine-phosphate diphosphorylase activity
MB46_RS12135	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MB46_RS12140	COG2318	DinB family
MB46_RS12155	COG1846	Transcriptional regulator
MB46_RS12170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MB46_RS12180	COG2072	flavoprotein involved in K transport
MB46_RS12215	COG0024	Methionine aminopeptidase
MB46_RS12230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MB46_RS12235	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MB46_RS12240	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MB46_RS12250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MB46_RS12255	COG0509	glycine decarboxylation via glycine cleavage system
MB46_RS12260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MB46_RS12265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MB46_RS12265	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MB46_RS12270	COG1113	amino acid transport
MB46_RS12280	COG0583	DNA-binding transcription factor activity
MB46_RS12285	COG2814	Major facilitator Superfamily
MB46_RS12290	COG0477	Major facilitator Superfamily
MB46_RS12305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MB46_RS12310	COG0765	amino acid transport
MB46_RS12315	COG1126	abc transporter atp-binding protein
MB46_RS12320	COG0251	oxidation-reduction process
MB46_RS12340	COG0513	Belongs to the DEAD box helicase family
MB46_RS12355	COG0006	proline dipeptidase activity
MB46_RS12375	COG2239	Acts as a magnesium transporter
MB46_RS12390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MB46_RS12395	COG1595	DNA-templated transcription, initiation
MB46_RS12400	COG4122	O-methyltransferase activity
MB46_RS12415	COG0519	Catalyzes the synthesis of GMP from XMP
MB46_RS12430	COG1126	abc transporter atp-binding protein
MB46_RS12435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MB46_RS12440	COG0765	amino acid transport
MB46_RS12445	COG0765	amino acid transport
MB46_RS12450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MB46_RS12460	COG1595	DNA-templated transcription, initiation
MB46_RS12475	COG2171	N-acyltransferase activity
MB46_RS12490	COG3226	Transcriptional regulator
MB46_RS12525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MB46_RS12535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MB46_RS12540	COG0601	transmembrane transport
MB46_RS12550	COG1217	gtp-binding protein TYPA
MB46_RS12555	COG0747	negative chemotaxis
MB46_RS12560	COG2318	DinB family
MB46_RS12575	COG2354	Protein conserved in bacteria
MB46_RS12610	COG2226	methyltransferase
MB46_RS12645	COG0012	GTP binding
MB46_RS12655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MB46_RS12665	COG1570	exodeoxyribonuclease VII activity
MB46_RS12670	COG1722	exodeoxyribonuclease VII activity
MB46_RS12680	COG2326	polyphosphate kinase activity
MB46_RS12700	COG1609	Transcriptional regulator
MB46_RS12705	COG2971	BadF BadG BcrA BcrD
MB46_RS12710	COG2070	2-Nitropropane dioxygenase
MB46_RS12720	COG0598	Magnesium transport protein CorA
MB46_RS12730	COG0778	Nitroreductase
MB46_RS12740	COG0039	L-malate dehydrogenase activity
MB46_RS12755	COG1309	transcriptional regulator
MB46_RS12760	COG1131	(ABC) transporter
MB46_RS12790	COG2409	Drug exporters of the RND superfamily
MB46_RS12805	COG0488	(ABC) transporter
MB46_RS12815	COG2160	L-arabinose isomerase activity
MB46_RS12830	COG1609	Transcriptional regulator
MB46_RS12835	COG2017	converts alpha-aldose to the beta-anomer
MB46_RS12850	COG0583	DNA-binding transcription factor activity
MB46_RS12855	COG2313	pseudouridylate synthase activity
MB46_RS12860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MB46_RS12865	COG0477	Major facilitator Superfamily
MB46_RS12870	COG3711	transcriptional antiterminator
MB46_RS12875	COG2190	(PTS) system
MB46_RS12880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MB46_RS12880	COG2190	(PTS) system
MB46_RS12880	COG1263	PTS System
MB46_RS12890	COG1064	alcohol dehydrogenase
MB46_RS12895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MB46_RS12900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MB46_RS12905	COG1695	Transcriptional regulator
MB46_RS12935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MB46_RS12940	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MB46_RS12965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MB46_RS12965	COG0519	Catalyzes the synthesis of GMP from XMP
MB46_RS12985	COG0516	GMP reductase activity
MB46_RS13025	COG2755	lipolytic protein G-D-S-L family
MB46_RS13025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MB46_RS13035	COG0459	protein refolding
MB46_RS13040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MB46_RS13085	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MB46_RS13090	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MB46_RS13095	COG2130	NADP-dependent
MB46_RS13125	COG0395	ABC-type sugar transport system, permease component
MB46_RS13135	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MB46_RS13140	COG0456	acetyltransferase
MB46_RS13150	COG0802	atpase or kinase
MB46_RS13155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MB46_RS13160	COG0438	transferase activity, transferring glycosyl groups
MB46_RS13175	COG1846	Transcriptional regulator
MB46_RS13175	COG1940	carbohydrate kinase activity
MB46_RS13190	COG1175	transmembrane transport
MB46_RS13195	COG0395	ABC-type sugar transport system, permease component
MB46_RS13215	COG0667	Aldo Keto reductase
MB46_RS13230	COG0736	holo-[acyl-carrier-protein] synthase activity
MB46_RS13235	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MB46_RS13240	COG1072	(Pantothenic acid kinase))
MB46_RS13250	COG1970	mechanosensitive ion channel activity
MB46_RS13255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MB46_RS13260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MB46_RS13265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MB46_RS13270	COG0101	tRNA pseudouridine synthase activity
MB46_RS13275	COG0203	ribosomal protein L17
MB46_RS13280	COG0202	RNA polymerase activity
MB46_RS13285	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MB46_RS13290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MB46_RS13295	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MB46_RS13300	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MB46_RS13305	COG3191	aminopeptidase activity
MB46_RS13310	COG1653	transport
MB46_RS13320	COG1175	transmembrane transport
MB46_RS13330	COG0024	Methionine aminopeptidase
MB46_RS13335	COG0563	adenylate kinase activity
MB46_RS13345	COG0200	Binds to the 23S rRNA
MB46_RS13350	COG1841	ribosomal large subunit assembly
MB46_RS13355	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MB46_RS13360	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MB46_RS13365	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MB46_RS13370	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MB46_RS13375	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MB46_RS13380	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MB46_RS13385	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MB46_RS13390	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MB46_RS13395	COG0255	Belongs to the universal ribosomal protein uL29 family
MB46_RS13400	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MB46_RS13405	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MB46_RS13410	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MB46_RS13415	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MB46_RS13420	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MB46_RS13425	COG0089	rRNA binding
MB46_RS13430	COG0088	Forms part of the polypeptide exit tunnel
MB46_RS13435	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MB46_RS13440	COG0051	transcription antitermination factor activity, RNA binding
MB46_RS13455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MB46_RS13460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MB46_RS13465	COG0049	tRNA binding
MB46_RS13470	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MB46_RS13475	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MB46_RS13480	COG0085	RNA polymerase activity
MB46_RS13485	COG0183	Belongs to the thiolase family
MB46_RS13495	COG0222	ribosome binding
MB46_RS13500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MB46_RS13515	COG0081	regulation of translation
MB46_RS13520	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MB46_RS13525	COG0250	Participates in transcription elongation, termination and antitermination
MB46_RS13540	COG0436	Aminotransferase
MB46_RS13545	COG2197	response regulator
MB46_RS13590	COG3485	protocatechuate 3,4-dioxygenase
MB46_RS13600	COG0745	RESPONSE REGULATOR receiver
MB46_RS13615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MB46_RS13630	COG1175	transmembrane transport
MB46_RS13635	COG0395	ABC-type sugar transport system, permease component
MB46_RS13645	COG0456	acetyltransferase
MB46_RS13650	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MB46_RS13655	COG0494	nUDIX hydrolase
MB46_RS13655	COG0406	alpha-ribazole phosphatase activity
MB46_RS13675	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MB46_RS13700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MB46_RS13720	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MB46_RS13725	COG2223	nitrite transmembrane transporter activity
MB46_RS13735	COG2030	dehydratase
MB46_RS13745	COG0477	Major facilitator Superfamily
MB46_RS13760	COG2301	Belongs to the HpcH HpaI aldolase family
MB46_RS13780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MB46_RS13790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MB46_RS13795	COG0025	NhaP-type Na H and K H
MB46_RS13835	COG0477	Major facilitator Superfamily
MB46_RS13850	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MB46_RS13855	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MB46_RS13860	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MB46_RS13865	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS13870	COG0402	S-adenosylhomocysteine deaminase activity
MB46_RS13875	COG1652	LysM domain
MB46_RS13920	COG1012	belongs to the aldehyde dehydrogenase family
MB46_RS13925	COG0583	DNA-binding transcription factor activity
MB46_RS13935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MB46_RS13945	COG1116	anion transmembrane transporter activity
MB46_RS13950	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MB46_RS13960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MB46_RS13965	COG2390	Transcriptional regulator
MB46_RS13970	COG1063	alcohol dehydrogenase
MB46_RS13975	COG2814	Major facilitator Superfamily
MB46_RS13980	COG2376	Dihydroxyacetone kinase
MB46_RS13985	COG0698	ribose 5-phosphate isomerase
MB46_RS13990	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS14000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MB46_RS14025	COG1666	GTP binding
MB46_RS14040	COG4585	Histidine kinase
MB46_RS14045	COG0406	alpha-ribazole phosphatase activity
MB46_RS14050	COG1247	-acetyltransferase
MB46_RS14060	COG0501	Belongs to the peptidase M48B family
MB46_RS14080	COG0753	catalase activity
MB46_RS14100	COG0531	amino acid
MB46_RS14125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MB46_RS14150	COG1012	belongs to the aldehyde dehydrogenase family
MB46_RS14190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MB46_RS14195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MB46_RS14195	COG1116	anion transmembrane transporter activity
MB46_RS14240	COG2895	sulfate adenylyltransferase (ATP) activity
MB46_RS14250	COG0175	sulfate reduction
MB46_RS14255	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MB46_RS14275	COG4152	abc transporter atp-binding protein
MB46_RS14280	COG2860	membrane
MB46_RS14295	COG0142	geranyltranstransferase activity
MB46_RS14305	COG2226	methyltransferase
MB46_RS14310	COG1169	isochorismate synthase
MB46_RS14315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MB46_RS14320	COG0765	amino acid transport
MB46_RS14325	COG1126	abc transporter atp-binding protein
MB46_RS14335	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MB46_RS14340	COG4948	Mandelate Racemase Muconate Lactonizing
MB46_RS14360	COG0508	dehydrogenase complex catalyzes the overall conversion of
MB46_RS14390	COG1597	lipid kinase activity
MB46_RS14405	COG0277	FAD linked oxidase domain protein
MB46_RS14420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MB46_RS14425	COG2151	metal-sulfur cluster biosynthetic enzyme
MB46_RS14430	COG3396	Phenylacetate-CoA oxygenase
MB46_RS14435	COG3460	Phenylacetate-CoA oxygenase
MB46_RS14440	COG3396	Phenylacetate-CoA oxygenase
MB46_RS14445	COG2050	protein possibly involved in aromatic compounds catabolism
MB46_RS14460	COG1012	belongs to the aldehyde dehydrogenase family
MB46_RS14460	COG2030	dehydratase
MB46_RS14465	COG1250	3-hydroxyacyl-CoA dehydrogenase
MB46_RS14470	COG1024	Enoyl-CoA hydratase
MB46_RS14485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MB46_RS14520	COG1472	Belongs to the glycosyl hydrolase 3 family
MB46_RS14530	COG4209	transmembrane transport
MB46_RS14535	COG0395	ABC-type sugar transport system, permease component
MB46_RS14540	COG1609	Transcriptional regulator
MB46_RS14550	COG1501	Belongs to the glycosyl hydrolase 31 family
MB46_RS14565	COG2365	Tyrosine phosphatase family
MB46_RS14575	COG2259	Doxx family
MB46_RS14585	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MB46_RS14645	COG1309	transcriptional regulator
MB46_RS14665	COG0386	Belongs to the glutathione peroxidase family
MB46_RS14685	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MB46_RS14695	COG0129	dihydroxy-acid dehydratase activity
MB46_RS14705	COG1131	(ABC) transporter
MB46_RS14725	COG1846	Transcriptional regulator
MB46_RS14755	COG2233	PERMEase
MB46_RS14760	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS14770	COG1953	Uracil, thiamine, allantoin
MB46_RS14775	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MB46_RS14800	COG1414	Transcriptional regulator
MB46_RS14810	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MB46_RS14820	COG3257	ureidoglycine aminohydrolase activity
MB46_RS14825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MB46_RS14830	COG3622	Belongs to the hyi family
MB46_RS14835	COG2084	Dehydrogenase
MB46_RS14840	COG3960	tartronate-semialdehyde synthase activity
MB46_RS14845	COG1929	Belongs to the glycerate kinase type-1 family
MB46_RS14850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MB46_RS14855	COG0508	dehydrogenase complex catalyzes the overall conversion of
MB46_RS14875	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MB46_RS14880	COG0047	phosphoribosylformylglycinamidine synthase activity
MB46_RS14885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MB46_RS14910	COG1832	CoA-binding protein
MB46_RS14920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MB46_RS14925	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MB46_RS14940	COG0191	fructose-bisphosphate aldolase activity
MB46_RS14945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MB46_RS14945	COG0357	Ribosomal RNA small subunit methyltransferase G
MB46_RS14960	COG1435	thymidine kinase activity
MB46_RS14965	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MB46_RS14970	COG4948	Mandelate Racemase Muconate Lactonizing
MB46_RS14980	COG0800	Aldolase
MB46_RS14985	COG4948	Mandelate Racemase Muconate Lactonizing
MB46_RS14990	COG0395	ABC-type sugar transport system, permease component
MB46_RS14995	COG1175	transmembrane transport
MB46_RS15025	COG3448	diguanylate cyclase activity
MB46_RS15025	COG4175	Glycine betaine
MB46_RS15040	COG1609	Transcriptional regulator
MB46_RS15065	COG0366	Alpha amylase catalytic
MB46_RS15145	COG2372	response to copper ion
MB46_RS15150	COG2252	PERMEase
MB46_RS15170	COG1902	pentaerythritol trinitrate reductase activity
MB46_RS15225	COG3387	PFAM Glycoside hydrolase 15-related
MB46_RS15230	COG0584	glycerophosphoryl diester phosphodiesterase
MB46_RS15235	COG2733	membrane
MB46_RS15265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MB46_RS15265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MB46_RS15265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MB46_RS15270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MB46_RS15275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MB46_RS15280	COG0477	Major facilitator Superfamily
MB46_RS15285	COG4221	oxidoreductase activity
MB46_RS15295	COG0351	phosphomethylpyrimidine kinase
MB46_RS15320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MB46_RS15335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MB46_RS15365	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MB46_RS15380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MB46_RS15380	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
MB46_RS15380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MB46_RS15390	COG2376	Dihydroxyacetone kinase
MB46_RS15395	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MB46_RS15420	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MB46_RS15425	COG1609	Transcriptional regulator
MB46_RS15430	COG1957	nucleoside hydrolase
MB46_RS15435	COG0477	Major facilitator Superfamily
MB46_RS15440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MB46_RS15445	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MB46_RS15475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MB46_RS15485	COG0302	gtp cyclohydrolase
MB46_RS15490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MB46_RS15500	COG0037	tRNA processing
MB46_RS15510	COG0745	RESPONSE REGULATOR receiver
MB46_RS15515	COG2205	protein histidine kinase activity
MB46_RS15550	COG2027	D-alanyl-D-alanine carboxypeptidase
MB46_RS15565	COG0561	phosphatase activity
MB46_RS15570	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MB46_RS15575	COG1597	lipid kinase activity
MB46_RS15595	COG1054	Belongs to the UPF0176 family
MB46_RS15600	COG3104	oligopeptide transport
MB46_RS15625	COG2233	PERMEase
MB46_RS15630	COG1929	Belongs to the glycerate kinase type-1 family
MB46_RS15640	COG0561	phosphatase activity
MB46_RS15650	COG1609	Transcriptional regulator
MB46_RS15660	COG0385	Bile acid
MB46_RS15725	COG2318	DinB family
MB46_RS15735	COG1556	Lactate utilization protein
MB46_RS15740	COG1139	Iron-sulfur cluster binding protein
MB46_RS15745	COG0247	lactate metabolic process
MB46_RS15760	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MB46_RS15790	COG3853	Toxic anion resistance protein (TelA)
MB46_RS15820	COG1358	cellular component organization or biogenesis
MB46_RS15880	COG1362	aminopeptidase activity
MB46_RS15885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MB46_RS15890	COG2197	response regulator
MB46_RS15895	COG4585	Histidine kinase
MB46_RS15910	COG0671	phosphoesterase, PA-phosphatase related
MB46_RS15915	COG0738	Major facilitator superfamily
MB46_RS15920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MB46_RS15925	COG2188	Transcriptional regulator
MB46_RS15955	COG0488	(ABC) transporter
MB46_RS15965	COG2197	response regulator
MB46_RS15980	COG2197	response regulator
MB46_RS15985	COG3850	Histidine kinase
MB46_RS15995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MB46_RS16015	COG0406	alpha-ribazole phosphatase activity
MB46_RS16020	COG0617	tRNA 3'-terminal CCA addition
MB46_RS16040	COG0492	ferredoxin-NADP+ reductase activity
MB46_RS16045	COG3118	belongs to the thioredoxin family
MB46_RS16075	COG1192	Involved in chromosome partitioning
MB46_RS16080	COG0357	Ribosomal RNA small subunit methyltransferase G
MB46_RS16090	COG0706	membrane insertase activity
MB46_RS16095	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MB46_RS16100	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MB46_RS16105	COG0592	DNA-directed DNA polymerase activity
MB46_RS16110	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MB46_RS16115	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MB46_RS16120	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
MB46_RS16125	COG0187	DNA topoisomerase II activity
MB46_RS16130	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MB46_RS16135	COG3266	domain, Protein
MB46_RS16165	COG0705	Rhomboid family
MB46_RS16195	COG3764	Sortase (surface protein transpeptidase)
MB46_RS16205	COG0515	serine threonine protein kinase
MB46_RS16210	COG0515	serine threonine protein kinase
MB46_RS16215	COG0768	penicillin binding
MB46_RS16230	COG1716	ATPase activity
MB46_RS16235	COG1716	ATPase activity
MB46_RS16295	COG0360	Binds together with S18 to 16S ribosomal RNA
MB46_RS16305	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MB46_RS16310	COG0359	binds to the 23S rRNA
MB46_RS16320	COG0305	Participates in initiation and elongation during chromosome replication
MB46_RS16360	COG4821	SIS domain
MB46_RS16365	COG1653	transport
MB46_RS16370	COG1175	transmembrane transport
MB46_RS16375	COG0395	ABC-type sugar transport system, permease component
MB46_RS16400	COG1937	Protein conserved in bacteria
MB46_RS16410	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MB46_RS16420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MB46_RS16430	COG2213	PTS system mannitol-specific
MB46_RS16430	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MB46_RS16435	COG0246	Mannitol dehydrogenase
MB46_RS16440	COG1063	alcohol dehydrogenase
MB46_RS16445	COG0395	ABC-type sugar transport system, permease component
MB46_RS16460	COG2390	Transcriptional regulator
MB46_RS16465	COG1070	Carbohydrate kinase
MB46_RS16475	COG0028	Belongs to the TPP enzyme family
MB46_RS16490	COG1802	Transcriptional regulator
MB46_RS16505	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MB46_RS16525	COG0436	Aminotransferase
MB46_RS16530	COG1607	acyl-coa hydrolase
MB46_RS16540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MB46_RS16555	COG1950	PFAM Membrane protein of
MB46_RS16560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MB46_RS16570	COG0022	dehydrogenase e1 component
MB46_RS16575	COG0508	dehydrogenase complex catalyzes the overall conversion of
MB46_RS16580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MB46_RS16610	COG0673	inositol 2-dehydrogenase activity
MB46_RS16615	COG2211	Major facilitator Superfamily
MB46_RS16655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MB46_RS16705	COG0517	IMP dehydrogenase activity
MB46_RS16705	COG1125	glycine betaine transport
MB46_RS16710	COG0435	Glutathione S-transferase
MB46_RS16730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MB46_RS16735	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MB46_RS16740	COG1120	ATPase activity
MB46_RS16750	COG2764	glyoxalase bleomycin resistance protein dioxygenase
MB46_RS16760	COG1132	(ABC) transporter
MB46_RS16770	COG2271	Major facilitator Superfamily
MB46_RS16775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MB46_RS16780	COG1960	acyl-CoA dehydrogenase activity
MB46_RS16790	COG0183	Belongs to the thiolase family
MB46_RS16795	COG2086	electron transfer activity
MB46_RS16800	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MB46_RS16830	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MB46_RS16835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MB46_RS16840	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MB46_RS16845	COG0776	regulation of translation
MB46_RS16850	COG1276	copper resistance
MB46_RS16850	COG2372	response to copper ion
MB46_RS16865	COG0433	COG0433 Predicted ATPase
MB46_RS16875	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MB46_RS16880	COG0583	DNA-binding transcription factor activity
MB46_RS16890	COG3239	Fatty acid desaturase
MB46_RS16900	COG3415	Transposase
MB46_RS16900	COG2801	Transposase and inactivated derivatives
MB46_RS16915	COG0475	glutathione-regulated potassium exporter activity
MB46_RS16920	COG0569	domain protein
MB46_RS16925	COG0717	Belongs to the dCTP deaminase family
MB46_RS16935	COG2111	Na H antiporter
MB46_RS16935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MB46_RS16940	COG1006	Multisubunit Na H antiporter MnhC subunit
MB46_RS16945	COG0651	ATP synthesis coupled electron transport
MB46_RS16950	COG1863	multisubunit Na H antiporter MnhE subunit
MB46_RS16955	COG2212	antiporter activity
MB46_RS16960	COG1320	monovalent cation:proton antiporter activity
MB46_RS16970	COG4721	ABC-type cobalt transport system, permease component
MB46_RS16975	COG1122	ATPase activity
MB46_RS16990	COG1175	transmembrane transport
MB46_RS16995	COG0395	ABC-type sugar transport system, permease component
MB46_RS17005	COG1609	Transcriptional regulator
MB46_RS17010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MB46_RS17055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MB46_RS17060	COG1280	lysine exporter protein (LysE YggA)
MB46_RS17070	COG0443	Heat shock 70 kDa protein
MB46_RS17075	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MB46_RS17080	COG0484	heat shock protein binding
MB46_RS17085	COG0789	Transcriptional regulator
MB46_RS17110	COG1175	transmembrane transport
MB46_RS17115	COG0395	ABC-type sugar transport system, permease component
MB46_RS17125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MB46_RS17135	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MB46_RS17145	COG0475	glutathione-regulated potassium exporter activity
MB46_RS17145	COG0569	domain protein
MB46_RS17150	COG0384	phenazine biosynthesis protein PhzF
MB46_RS17165	COG3304	Inner membrane component domain
MB46_RS17185	COG2197	response regulator
MB46_RS17190	COG4585	Histidine kinase
MB46_RS17215	COG2226	methyltransferase
MB46_RS17225	COG0542	response to heat
MB46_RS17240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MB46_RS17280	COG0151	Belongs to the GarS family
MB46_RS17285	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MB46_RS17300	COG2824	Alkylphosphonate utilization operon protein PhnA
MB46_RS17310	COG1408	metallophosphoesterase
MB46_RS17315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MB46_RS17340	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MB46_RS17345	COG1349	DNA-binding transcription factor activity
MB46_RS17350	COG0395	ABC-type sugar transport system, permease component
MB46_RS17355	COG1175	transmembrane transport
MB46_RS17360	COG1653	transport
MB46_RS17370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MB46_RS17425	COG1205	dead DEAH box helicase
MB46_RS17425	COG1111	helicase
MB46_RS17435	COG1054	Belongs to the UPF0176 family
MB46_RS17445	COG2890	protein-(glutamine-N5) methyltransferase activity
MB46_RS17450	COG1754	DNA topoisomerase type I activity
MB46_RS17450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MB46_RS17455	COG0248	Ppx GppA phosphatase
MB46_RS17460	COG1082	Xylose isomerase domain protein TIM barrel
MB46_RS17485	COG1522	sequence-specific DNA binding
MB46_RS17490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MB46_RS17500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MB46_RS17505	COG0569	domain protein
MB46_RS17510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MB46_RS17515	COG0123	including yeast histone deacetylase and acetoin utilization protein
MB46_RS17530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MB46_RS17540	COG1175	transmembrane transport
MB46_RS17545	COG0395	ABC-type sugar transport system, permease component
MB46_RS17560	COG2755	lipolytic protein G-D-S-L family
MB46_RS17565	COG3401	FG-GAP repeat protein
MB46_RS17595	COG3347	Dehydrogenase
MB46_RS17595	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS17600	COG1070	Carbohydrate kinase
MB46_RS17605	COG1113	amino acid transport
MB46_RS17620	COG1609	Transcriptional regulator
MB46_RS17625	COG0673	inositol 2-dehydrogenase activity
MB46_RS17635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MB46_RS17640	COG4948	Mandelate Racemase Muconate Lactonizing
MB46_RS17670	COG1653	transport
MB46_RS17675	COG0657	acetylesterase activity
MB46_RS17675	COG2755	lipolytic protein G-D-S-L family
MB46_RS17695	COG0673	inositol 2-dehydrogenase activity
MB46_RS17710	COG1175	transmembrane transport
MB46_RS17715	COG0395	ABC-type sugar transport system, permease component
MB46_RS17720	COG1609	Transcriptional regulator
MB46_RS17725	COG3458	cephalosporin-C deacetylase activity
MB46_RS17730	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MB46_RS17750	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MB46_RS17765	COG2353	YceI-like domain
MB46_RS17770	COG0406	alpha-ribazole phosphatase activity
MB46_RS17780	COG0785	Cytochrome C biogenesis protein
MB46_RS17785	COG1333	cytochrome c biogenesis protein
MB46_RS17790	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MB46_RS17800	COG0488	(ABC) transporter
MB46_RS17825	COG1609	Transcriptional regulator
MB46_RS17835	COG1175	transmembrane transport
MB46_RS17840	COG3833	ABC-type maltose transport systems, permease component
MB46_RS17875	COG1228	amidohydrolase
MB46_RS17930	COG1695	Transcriptional regulator
MB46_RS18045	COG0110	maltose O-acetyltransferase activity
MB46_RS18090	COG0642	Histidine kinase
MB46_RS18090	COG3850	Histidine kinase
MB46_RS18100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MB46_RS18105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MB46_RS18175	COG1132	(ABC) transporter
MB46_RS18180	COG1132	(ABC) transporter
MB46_RS18185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MB46_RS18190	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MB46_RS18210	COG0673	inositol 2-dehydrogenase activity
MB46_RS18215	COG0673	inositol 2-dehydrogenase activity
MB46_RS18230	COG1609	Transcriptional regulator
MB46_RS18240	COG1175	transmembrane transport
MB46_RS18245	COG0395	ABC-type sugar transport system, permease component
MB46_RS18250	COG0673	inositol 2-dehydrogenase activity
MB46_RS18260	COG0823	Involved in the tonB-independent uptake of proteins
MB46_RS18265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MB46_RS18275	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MB46_RS18305	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MB46_RS18315	COG0604	alcohol dehydrogenase
MB46_RS18340	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MB46_RS18340	COG1473	amidohydrolase
MB46_RS18345	COG1737	Transcriptional regulator
MB46_RS18365	COG0343	queuine tRNA-ribosyltransferase activity
MB46_RS18425	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MB46_RS18435	COG1302	Protein conserved in bacteria
MB46_RS18485	COG0564	pseudouridine synthase activity
MB46_RS18495	COG0456	acetyltransferase
MB46_RS18505	COG0456	acetyltransferase
MB46_RS18520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MB46_RS18525	COG1201	RNA secondary structure unwinding
MB46_RS18550	COG2205	protein histidine kinase activity
MB46_RS18555	COG0745	RESPONSE REGULATOR receiver
MB46_RS18715	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MB46_RS18745	COG2062	phosphohistidine phosphatase, SixA
MB46_RS18750	COG1511	domain protein
MB46_RS18760	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
MB46_RS18765	COG1940	carbohydrate kinase activity
MB46_RS18770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MB46_RS18775	COG4608	Belongs to the ABC transporter superfamily
MB46_RS18780	COG0444	Belongs to the ABC transporter superfamily
MB46_RS18795	COG2186	Transcriptional regulator
MB46_RS18805	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
MB46_RS18810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MB46_RS18810	COG1017	nitric oxide dioxygenase activity
MB46_RS18815	COG1959	2 iron, 2 sulfur cluster binding
MB46_RS18830	COG0514	ATP-dependent DNA helicase (RecQ)
MB46_RS18835	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS18845	COG4948	Mandelate Racemase Muconate Lactonizing
MB46_RS18875	COG1172	Belongs to the binding-protein-dependent transport system permease family
MB46_RS18880	COG1879	ABC-type sugar transport system periplasmic component
MB46_RS18895	COG1175	transmembrane transport
MB46_RS18900	COG0395	ABC-type sugar transport system, permease component
MB46_RS18920	COG2186	Transcriptional regulator
MB46_RS18930	COG1505	serine-type exopeptidase activity
MB46_RS18950	COG0604	alcohol dehydrogenase
MB46_RS18950	COG1028	Short-chain dehydrogenase reductase Sdr
MB46_RS18950	COG3321	synthase
MB46_RS18955	COG1966	Carbon starvation protein
MB46_RS18985	COG3842	ATPase activity
MB46_RS19010	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MB46_RS19015	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MB46_RS19030	COG0384	phenazine biosynthesis protein PhzF
MB46_RS19040	COG0588	phosphoglycerate mutase activity
MB46_RS19045	COG0704	Plays a role in the regulation of phosphate uptake
MB46_RS19050	COG5002	protein histidine kinase activity
MB46_RS19070	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MB46_RS19075	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MB46_RS19080	COG0215	cysteine-tRNA ligase activity
MB46_RS19085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MB46_RS19100	COG0366	Alpha amylase catalytic
MB46_RS19110	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MB46_RS19445	COG0395	ABC-type sugar transport system, permease component
MB46_RS19495	COG3962	Belongs to the TPP enzyme family
MB46_RS19715	COG1027	Aspartate ammonia-lyase