locus-tag	class	description
GJB52_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GJB52_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GJB52_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GJB52_RS00030	COG0187	DNA topoisomerase II activity
GJB52_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GJB52_RS00040	COG3266	domain, Protein
GJB52_RS00070	COG0705	Rhomboid family
GJB52_RS00080	COG0596	Alpha beta hydrolase
GJB52_RS00090	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GJB52_RS00105	COG3764	Sortase (surface protein transpeptidase)
GJB52_RS00120	COG0515	serine threonine protein kinase
GJB52_RS00125	COG0768	penicillin binding
GJB52_RS00140	COG1716	ATPase activity
GJB52_RS00145	COG1716	ATPase activity
GJB52_RS00260	COG1358	cellular component organization or biogenesis
GJB52_RS00290	COG3853	Toxic anion resistance protein (TelA)
GJB52_RS00325	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GJB52_RS00335	COG1522	sequence-specific DNA binding
GJB52_RS00340	COG0247	lactate metabolic process
GJB52_RS00345	COG1139	Iron-sulfur cluster binding protein
GJB52_RS00350	COG1556	Lactate utilization protein
GJB52_RS00370	COG1063	alcohol dehydrogenase
GJB52_RS00375	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GJB52_RS00385	COG4786	Flagellar basal body rod
GJB52_RS00385	COG1256	bacterial-type flagellum assembly
GJB52_RS00400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GJB52_RS00420	COG1815	bacterial-type flagellum-dependent cell motility
GJB52_RS00430	COG1677	Flagellar hook-basal body complex protein FliE
GJB52_RS00450	COG1157	protein secretion by the type III secretion system
GJB52_RS00465	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GJB52_RS00505	COG1338	Plays a role in the flagellum-specific transport system
GJB52_RS00520	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GJB52_RS00525	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GJB52_RS00535	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GJB52_RS00595	COG2409	Drug exporters of the RND superfamily
GJB52_RS00600	COG0006	proline dipeptidase activity
GJB52_RS00630	COG3938	Belongs to the proline racemase family
GJB52_RS00645	COG2197	response regulator
GJB52_RS00660	COG3938	Belongs to the proline racemase family
GJB52_RS00680	COG1802	Transcriptional regulator
GJB52_RS00720	COG0561	phosphatase activity
GJB52_RS00730	COG1929	Belongs to the glycerate kinase type-1 family
GJB52_RS00735	COG2233	PERMEase
GJB52_RS00765	COG3104	oligopeptide transport
GJB52_RS00770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GJB52_RS00785	COG1597	lipid kinase activity
GJB52_RS00790	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GJB52_RS00795	COG0561	phosphatase activity
GJB52_RS00830	COG2027	D-alanyl-D-alanine carboxypeptidase
GJB52_RS00840	COG0037	tRNA processing
GJB52_RS00850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GJB52_RS00855	COG0302	gtp cyclohydrolase
GJB52_RS00865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GJB52_RS00895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GJB52_RS00900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GJB52_RS00905	COG0477	Major facilitator Superfamily
GJB52_RS00915	COG1609	Transcriptional regulator
GJB52_RS00920	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GJB52_RS00935	COG3548	integral membrane protein
GJB52_RS00945	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GJB52_RS00950	COG2376	Dihydroxyacetone kinase
GJB52_RS00955	COG1461	Dihydroxyacetone kinase
GJB52_RS00960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GJB52_RS00960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GJB52_RS00960	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GJB52_RS00975	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GJB52_RS00995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GJB52_RS01010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GJB52_RS01045	COG1335	isochorismatase
GJB52_RS01050	COG0351	phosphomethylpyrimidine kinase
GJB52_RS01060	COG4221	oxidoreductase activity
GJB52_RS01070	COG0477	Major facilitator Superfamily
GJB52_RS01075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GJB52_RS01075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GJB52_RS01075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GJB52_RS01085	COG1349	DNA-binding transcription factor activity
GJB52_RS01105	COG2733	membrane
GJB52_RS01110	COG0584	glycerophosphoryl diester phosphodiesterase
GJB52_RS01115	COG3387	PFAM Glycoside hydrolase 15-related
GJB52_RS01145	COG4122	O-methyltransferase activity
GJB52_RS01200	COG0010	Belongs to the arginase family
GJB52_RS01205	COG2252	PERMEase
GJB52_RS01210	COG2372	response to copper ion
GJB52_RS01235	COG0791	NLP P60 protein
GJB52_RS01235	COG3883	PFAM NLP P60 protein
GJB52_RS01290	COG2826	transposase and inactivated derivatives, IS30 family
GJB52_RS01330	COG4175	Glycine betaine
GJB52_RS01330	COG0517	IMP dehydrogenase activity
GJB52_RS01335	COG4176	ABC-type proline glycine betaine transport system permease component
GJB52_RS01350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GJB52_RS01355	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GJB52_RS01360	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GJB52_RS01365	COG1435	thymidine kinase activity
GJB52_RS01385	COG0191	fructose-bisphosphate aldolase activity
GJB52_RS01415	COG0477	Major facilitator Superfamily
GJB52_RS01430	COG1028	Short-chain dehydrogenase reductase Sdr
GJB52_RS01435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GJB52_RS01440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GJB52_RS01450	COG1832	CoA-binding protein
GJB52_RS01475	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GJB52_RS01480	COG0047	phosphoribosylformylglycinamidine synthase activity
GJB52_RS01485	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GJB52_RS01495	COG1846	Transcriptional regulator
GJB52_RS01520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GJB52_RS01525	COG2076	Multidrug Resistance protein
GJB52_RS01535	COG1012	belongs to the aldehyde dehydrogenase family
GJB52_RS01550	COG4555	ABC transporter
GJB52_RS01560	COG0129	dihydroxy-acid dehydratase activity
GJB52_RS01570	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GJB52_RS01595	COG0386	Belongs to the glutathione peroxidase family
GJB52_RS01615	COG1309	transcriptional regulator
GJB52_RS01665	COG4942	peptidase
GJB52_RS01670	COG4565	transcriptional regulatory protein
GJB52_RS01675	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GJB52_RS01695	COG0488	(ABC) transporter
GJB52_RS01730	COG1132	(ABC) transporter
GJB52_RS01735	COG1132	(ABC) transporter
GJB52_RS01740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GJB52_RS01755	COG0673	inositol 2-dehydrogenase activity
GJB52_RS01760	COG0673	inositol 2-dehydrogenase activity
GJB52_RS01775	COG1609	Transcriptional regulator
GJB52_RS01785	COG1175	transmembrane transport
GJB52_RS01790	COG0395	ABC-type sugar transport system, permease component
GJB52_RS01810	COG0492	ferredoxin-NADP+ reductase activity
GJB52_RS01810	COG3118	belongs to the thioredoxin family
GJB52_RS01820	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GJB52_RS01825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GJB52_RS01835	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GJB52_RS01845	COG1476	TRANSCRIPTIONal
GJB52_RS01860	COG1960	acyl-CoA dehydrogenase activity
GJB52_RS01895	COG3971	2-oxopent-4-enoate hydratase activity
GJB52_RS01905	COG1012	belongs to the aldehyde dehydrogenase family
GJB52_RS01910	COG1802	Transcriptional regulator
GJB52_RS01920	COG1522	sequence-specific DNA binding
GJB52_RS01925	COG0028	Belongs to the TPP enzyme family
GJB52_RS01950	COG3226	Transcriptional regulator
GJB52_RS01970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GJB52_RS01995	COG3483	tryptophan 2,3-dioxygenase activity
GJB52_RS02010	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GJB52_RS02010	COG1473	amidohydrolase
GJB52_RS02015	COG1737	Transcriptional regulator
GJB52_RS02040	COG0343	queuine tRNA-ribosyltransferase activity
GJB52_RS02070	COG0601	transmembrane transport
GJB52_RS02075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GJB52_RS02080	COG4172	Belongs to the ABC transporter superfamily
GJB52_RS02090	COG1028	Short-chain dehydrogenase reductase Sdr
GJB52_RS02095	COG1012	belongs to the aldehyde dehydrogenase family
GJB52_RS02100	COG0473	3-isopropylmalate dehydrogenase activity
GJB52_RS02135	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GJB52_RS02145	COG1302	Protein conserved in bacteria
GJB52_RS02185	COG0564	pseudouridine synthase activity
GJB52_RS02205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GJB52_RS02210	COG1201	RNA secondary structure unwinding
GJB52_RS02235	COG2205	protein histidine kinase activity
GJB52_RS02240	COG0745	RESPONSE REGULATOR receiver
GJB52_RS02270	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GJB52_RS02295	COG2062	phosphohistidine phosphatase, SixA
GJB52_RS02300	COG1511	domain protein
GJB52_RS02315	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GJB52_RS02320	COG1940	carbohydrate kinase activity
GJB52_RS02330	COG4608	Belongs to the ABC transporter superfamily
GJB52_RS02335	COG0444	Belongs to the ABC transporter superfamily
GJB52_RS02340	COG0601	transmembrane transport
GJB52_RS02350	COG2186	Transcriptional regulator
GJB52_RS02365	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GJB52_RS02375	COG1959	2 iron, 2 sulfur cluster binding
GJB52_RS02390	COG0514	ATP-dependent DNA helicase (RecQ)
GJB52_RS02395	COG1028	Short-chain dehydrogenase reductase Sdr
GJB52_RS02405	COG4948	Mandelate Racemase Muconate Lactonizing
GJB52_RS02435	COG1172	Belongs to the binding-protein-dependent transport system permease family
GJB52_RS02440	COG1879	ABC-type sugar transport system periplasmic component
GJB52_RS02445	COG2186	Transcriptional regulator
GJB52_RS02455	COG1505	serine-type exopeptidase activity
GJB52_RS02470	COG0604	alcohol dehydrogenase
GJB52_RS02470	COG3321	synthase
GJB52_RS02470	COG1028	Short-chain dehydrogenase reductase Sdr
GJB52_RS02475	COG1966	Carbon starvation protein
GJB52_RS02505	COG3842	ATPase activity
GJB52_RS02525	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GJB52_RS02530	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GJB52_RS02535	COG0626	cystathionine gamma-synthase activity
GJB52_RS02550	COG0588	phosphoglycerate mutase activity
GJB52_RS02555	COG0704	Plays a role in the regulation of phosphate uptake
GJB52_RS02560	COG5002	protein histidine kinase activity
GJB52_RS02580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GJB52_RS02585	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GJB52_RS02590	COG0215	cysteine-tRNA ligase activity
GJB52_RS02595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GJB52_RS02610	COG0366	Alpha amylase catalytic
GJB52_RS02615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GJB52_RS02660	COG0277	FAD linked oxidase domain protein
GJB52_RS02675	COG3842	ATPase activity
GJB52_RS02790	COG1192	Involved in chromosome partitioning
GJB52_RS02800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GJB52_RS02810	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GJB52_RS02820	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GJB52_RS02855	COG1846	Transcriptional regulator
GJB52_RS02855	COG1940	carbohydrate kinase activity
GJB52_RS02885	COG0277	FAD linked oxidase domain protein
GJB52_RS02890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GJB52_RS02895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GJB52_RS02900	COG2814	Major facilitator Superfamily
GJB52_RS02915	COG1024	Enoyl-CoA hydratase
GJB52_RS02920	COG1024	Enoyl-CoA hydratase
GJB52_RS02935	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GJB52_RS02940	COG0477	Major facilitator Superfamily
GJB52_RS02955	COG1024	Enoyl-CoA hydratase
GJB52_RS03015	COG1175	transmembrane transport
GJB52_RS03020	COG0395	ABC-type sugar transport system, permease component
GJB52_RS03035	COG1609	Transcriptional regulator
GJB52_RS03040	COG1940	carbohydrate kinase activity
GJB52_RS03045	COG0366	Alpha amylase catalytic
GJB52_RS03050	COG0395	ABC-type sugar transport system, permease component
GJB52_RS03055	COG1175	transmembrane transport
GJB52_RS03065	COG1940	carbohydrate kinase activity
GJB52_RS03115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GJB52_RS03120	COG1120	ATPase activity
GJB52_RS03125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GJB52_RS03130	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GJB52_RS03135	COG1132	(ABC) transporter
GJB52_RS03150	COG1132	(ABC) transporter
GJB52_RS03165	COG1120	ATPase activity
GJB52_RS03170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GJB52_RS03190	COG0747	negative chemotaxis
GJB52_RS03205	COG4608	Belongs to the ABC transporter superfamily
GJB52_RS03210	COG0673	inositol 2-dehydrogenase activity
GJB52_RS03235	COG0395	ABC-type sugar transport system, permease component
GJB52_RS03240	COG1175	transmembrane transport
GJB52_RS03260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GJB52_RS03270	COG0730	response to heat
GJB52_RS03280	COG0477	Major facilitator Superfamily
GJB52_RS03290	COG1937	Protein conserved in bacteria
GJB52_RS03305	COG1846	Transcriptional regulator
GJB52_RS03305	COG1940	carbohydrate kinase activity
GJB52_RS03310	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GJB52_RS03315	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GJB52_RS03320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GJB52_RS03325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GJB52_RS03350	COG1940	carbohydrate kinase activity
GJB52_RS03355	COG1012	belongs to the aldehyde dehydrogenase family
GJB52_RS03360	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GJB52_RS03365	COG0251	oxidation-reduction process
GJB52_RS03370	COG0477	Major facilitator Superfamily
GJB52_RS03380	COG0028	Belongs to the TPP enzyme family
GJB52_RS03385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GJB52_RS03390	COG1940	carbohydrate kinase activity
GJB52_RS03425	COG3142	Participates in the control of copper homeostasis
GJB52_RS03440	COG0789	Transcriptional regulator
GJB52_RS03465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GJB52_RS03470	COG4133	protoheme IX ABC transporter activity
GJB52_RS03475	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GJB52_RS03480	COG1172	Belongs to the binding-protein-dependent transport system permease family
GJB52_RS03485	COG1129	ABC transporter
GJB52_RS03490	COG1869	D-ribose catabolic process
GJB52_RS03495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GJB52_RS03500	COG1609	Transcriptional regulator
GJB52_RS03510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GJB52_RS03520	COG1960	acyl-CoA dehydrogenase activity
GJB52_RS03530	COG1309	transcriptional regulator
GJB52_RS03550	COG1012	belongs to the aldehyde dehydrogenase family
GJB52_RS03555	COG0477	Major facilitator Superfamily
GJB52_RS03560	COG2030	dehydratase
GJB52_RS03570	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GJB52_RS03580	COG1028	Short-chain dehydrogenase reductase Sdr
GJB52_RS03625	COG1024	Enoyl-CoA hydratase
GJB52_RS03640	COG2080	2 iron, 2 sulfur cluster binding
GJB52_RS03655	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GJB52_RS03655	COG3608	succinylglutamate desuccinylase aspartoacylase
GJB52_RS03660	COG1802	Transcriptional regulator
GJB52_RS03665	COG1335	isochorismatase
GJB52_RS03680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GJB52_RS03685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GJB52_RS03690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GJB52_RS03695	COG0066	3-isopropylmalate dehydratase activity
GJB52_RS03715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GJB52_RS03720	COG0165	Argininosuccinate lyase
GJB52_RS03725	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GJB52_RS03730	COG3842	ATPase activity
GJB52_RS03740	COG1940	carbohydrate kinase activity
GJB52_RS03745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GJB52_RS03765	COG1960	acyl-CoA dehydrogenase activity
GJB52_RS03775	COG0183	Belongs to the thiolase family
GJB52_RS03780	COG0183	Belongs to the thiolase family
GJB52_RS03785	COG0318	PFAM AMP-dependent synthetase and ligase
GJB52_RS03800	COG2050	protein possibly involved in aromatic compounds catabolism
GJB52_RS03805	COG0183	Belongs to the thiolase family
GJB52_RS03815	COG2070	2-Nitropropane dioxygenase
GJB52_RS03875	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GJB52_RS03895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GJB52_RS03900	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GJB52_RS03905	COG0277	FAD linked oxidase domain protein
GJB52_RS03935	COG2372	response to copper ion
GJB52_RS03955	COG1028	Short-chain dehydrogenase reductase Sdr
GJB52_RS03970	COG1012	belongs to the aldehyde dehydrogenase family
GJB52_RS03980	COG1024	Enoyl-CoA hydratase
GJB52_RS04010	COG1136	(ABC) transporter
GJB52_RS04010	COG0577	efflux transmembrane transporter activity
GJB52_RS04035	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GJB52_RS04050	COG0459	protein refolding
GJB52_RS04055	COG0328	RNA-DNA hybrid ribonuclease activity
GJB52_RS04065	COG2205	protein histidine kinase activity
GJB52_RS04070	COG0745	RESPONSE REGULATOR receiver
GJB52_RS04075	COG3119	arylsulfatase activity
GJB52_RS04085	COG3119	arylsulfatase activity
GJB52_RS04090	COG0395	ABC-type sugar transport system, permease component
GJB52_RS04110	COG0673	inositol 2-dehydrogenase activity
GJB52_RS04125	COG3119	arylsulfatase activity
GJB52_RS04145	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GJB52_RS04185	COG1278	Cold shock
GJB52_RS04200	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GJB52_RS04210	COG0739	heme binding
GJB52_RS04215	COG3103	Sh3 type 3 domain protein
GJB52_RS04215	COG1388	LysM domain
GJB52_RS04215	COG0791	NLP P60 protein
GJB52_RS04260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GJB52_RS04285	COG1126	abc transporter atp-binding protein
GJB52_RS04290	COG0765	amino acid transport
GJB52_RS04295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GJB52_RS04300	COG1132	(ABC) transporter
GJB52_RS04305	COG1742	UPF0060 membrane protein
GJB52_RS04310	COG2962	Rard protein
GJB52_RS04325	COG0483	inositol monophosphate 1-phosphatase activity
GJB52_RS04340	COG0045	succinate-CoA ligase (ADP-forming) activity
GJB52_RS04365	COG1414	Transcriptional regulator
GJB52_RS04375	COG0477	Major facilitator Superfamily
GJB52_RS04405	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GJB52_RS04430	COG1760	l-serine dehydratase
GJB52_RS04460	COG1396	sequence-specific DNA binding
GJB52_RS04475	COG0028	Belongs to the TPP enzyme family
GJB52_RS04490	COG1309	transcriptional regulator
GJB52_RS04495	COG1090	epimerase
GJB52_RS04515	COG2186	Transcriptional regulator
GJB52_RS04525	COG1027	Aspartate ammonia-lyase
GJB52_RS04580	COG1185	polyribonucleotide nucleotidyltransferase activity
GJB52_RS04665	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GJB52_RS04685	COG3634	alkyl hydroperoxide reductase activity
GJB52_RS04700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GJB52_RS04705	COG1960	acyl-CoA dehydrogenase activity
GJB52_RS04720	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GJB52_RS04720	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GJB52_RS04730	COG1278	Cold shock
GJB52_RS04755	COG0477	Major facilitator Superfamily
GJB52_RS04760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GJB52_RS04765	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GJB52_RS04770	COG1472	Belongs to the glycosyl hydrolase 3 family
GJB52_RS04775	COG0138	bifunctional purine biosynthesis protein purh
GJB52_RS04785	COG2838	Isocitrate dehydrogenase
GJB52_RS04815	COG0673	inositol 2-dehydrogenase activity
GJB52_RS04820	COG4213	ABC transporter substrate-binding protein
GJB52_RS04825	COG4214	carbohydrate transport
GJB52_RS04835	COG1940	carbohydrate kinase activity
GJB52_RS04850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GJB52_RS04855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GJB52_RS04870	COG2197	response regulator
GJB52_RS04895	COG0180	Tryptophanyl-tRNA synthetase
GJB52_RS04915	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GJB52_RS04930	COG2009	succinate dehydrogenase
GJB52_RS04940	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GJB52_RS04940	COG1473	amidohydrolase
GJB52_RS04950	COG3845	ABC transporter
GJB52_RS04955	COG4603	Belongs to the binding-protein-dependent transport system permease family
GJB52_RS04960	COG1079	Belongs to the binding-protein-dependent transport system permease family
GJB52_RS04975	COG0586	Pfam SNARE associated Golgi protein
GJB52_RS04980	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GJB52_RS04985	COG3956	TIGRFAM MazG family protein
GJB52_RS04995	COG0148	phosphopyruvate hydratase activity
GJB52_RS05015	COG1404	Belongs to the peptidase S8 family
GJB52_RS05045	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GJB52_RS05055	COG1349	DNA-binding transcription factor activity
GJB52_RS05060	COG2017	converts alpha-aldose to the beta-anomer
GJB52_RS05070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GJB52_RS05075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GJB52_RS05085	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GJB52_RS05095	COG1331	Highly conserved protein containing a thioredoxin domain
GJB52_RS05105	COG0577	efflux transmembrane transporter activity
GJB52_RS05120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GJB52_RS05125	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GJB52_RS05160	COG0114	fumarate hydratase activity
GJB52_RS05165	COG0288	reversible hydration of carbon dioxide
GJB52_RS05175	COG1494	fructose-1,6-bisphosphatase
GJB52_RS05185	COG1482	cell wall glycoprotein biosynthetic process
GJB52_RS05190	COG1316	TRANSCRIPTIONal
GJB52_RS05245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GJB52_RS05250	COG1376	ErfK ybiS ycfS ynhG family protein
GJB52_RS05295	COG0714	Associated with various cellular activities
GJB52_RS05300	COG0084	hydrolase, TatD family'
GJB52_RS05305	COG3583	domain protein
GJB52_RS05310	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GJB52_RS05315	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GJB52_RS05320	COG0488	(ABC) transporter
GJB52_RS05335	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GJB52_RS05350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GJB52_RS05355	COG0193	aminoacyl-tRNA hydrolase activity
GJB52_RS05365	COG2197	response regulator
GJB52_RS05370	COG2197	response regulator
GJB52_RS05375	COG0529	Catalyzes the synthesis of activated sulfate
GJB52_RS05380	COG0730	response to heat
GJB52_RS05435	COG1215	transferase activity, transferring glycosyl groups
GJB52_RS05500	COG0822	iron-sulfur transferase activity
GJB52_RS05510	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GJB52_RS05520	COG5002	protein histidine kinase activity
GJB52_RS05550	COG5002	protein histidine kinase activity
GJB52_RS05555	COG0745	RESPONSE REGULATOR receiver
GJB52_RS05575	COG3979	chitinase
GJB52_RS05595	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GJB52_RS05605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GJB52_RS05625	COG0477	Major facilitator Superfamily
GJB52_RS05635	COG4770	biotin carboxylase activity
GJB52_RS05650	COG0424	maF-like protein
GJB52_RS05685	COG2409	Drug exporters of the RND superfamily
GJB52_RS05700	COG1823	symporter activity
GJB52_RS05720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GJB52_RS05740	COG1403	HNH endonuclease
GJB52_RS05770	COG0714	Associated with various cellular activities
GJB52_RS05780	COG1305	Transglutaminase-like
GJB52_RS05820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GJB52_RS05830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GJB52_RS05850	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GJB52_RS05855	COG0154	amidase activity
GJB52_RS05860	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GJB52_RS05890	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GJB52_RS05895	COG0583	DNA-binding transcription factor activity
GJB52_RS05900	COG1063	alcohol dehydrogenase
GJB52_RS05905	COG0156	8-amino-7-oxononanoate synthase activity
GJB52_RS05910	COG1228	amidohydrolase
GJB52_RS05925	COG1940	carbohydrate kinase activity
GJB52_RS05940	COG1349	DNA-binding transcription factor activity
GJB52_RS05945	COG2837	iron assimilation
GJB52_RS05950	COG2822	iron ion transport
GJB52_RS05960	COG0588	phosphoglycerate mutase activity
GJB52_RS05985	COG2183	response to ionizing radiation
GJB52_RS05990	COG2873	o-acetylhomoserine
GJB52_RS05995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GJB52_RS06030	COG0423	glycine-tRNA ligase activity
GJB52_RS06050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GJB52_RS06055	COG3424	synthase
GJB52_RS06060	COG2239	Acts as a magnesium transporter
GJB52_RS06065	COG1309	transcriptional regulator
GJB52_RS06070	COG1511	domain protein
GJB52_RS06075	COG4133	protoheme IX ABC transporter activity
GJB52_RS06090	COG0358	DNA primase activity
GJB52_RS06105	COG2814	Major facilitator Superfamily
GJB52_RS06125	COG0297	glycogen (starch) synthase activity
GJB52_RS06135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GJB52_RS06150	COG0052	Belongs to the universal ribosomal protein uS2 family
GJB52_RS06155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GJB52_RS06160	COG0528	UMP kinase activity
GJB52_RS06165	COG0233	cytoplasmic translational termination
GJB52_RS06170	COG0575	Belongs to the CDS family
GJB52_RS06180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GJB52_RS06195	COG3275	phosphorelay sensor kinase activity
GJB52_RS06215	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GJB52_RS06220	COG1522	sequence-specific DNA binding
GJB52_RS06230	COG0022	dehydrogenase e1 component
GJB52_RS06235	COG0508	dehydrogenase complex catalyzes the overall conversion of
GJB52_RS06250	COG1309	transcriptional regulator
GJB52_RS06255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GJB52_RS06265	COG1960	acyl-CoA dehydrogenase activity
GJB52_RS06290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GJB52_RS06295	COG0750	zinc metalloprotease
GJB52_RS06315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GJB52_RS06325	COG1902	pentaerythritol trinitrate reductase activity
GJB52_RS06325	COG0446	pyridine nucleotide-disulphide oxidoreductase
GJB52_RS06340	COG1309	transcriptional regulator
GJB52_RS06360	COG0442	prolyl-tRNA aminoacylation
GJB52_RS06370	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
GJB52_RS06385	COG0779	Required for maturation of 30S ribosomal subunits
GJB52_RS06390	COG0195	Participates in both transcription termination and antitermination
GJB52_RS06400	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GJB52_RS06405	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GJB52_RS06440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GJB52_RS06465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GJB52_RS06470	COG1185	polyribonucleotide nucleotidyltransferase activity
GJB52_RS06475	COG0612	Peptidase, M16
GJB52_RS06525	COG0315	cyclic pyranopterin monophosphate synthase activity
GJB52_RS06530	COG0315	cyclic pyranopterin monophosphate synthase activity
GJB52_RS06530	COG0521	Mo-molybdopterin cofactor biosynthetic process
GJB52_RS06540	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GJB52_RS06550	COG0596	Alpha beta hydrolase
GJB52_RS06555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GJB52_RS06560	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GJB52_RS06565	COG1674	ftsk spoiiie
GJB52_RS06575	COG1546	Belongs to the CinA family
GJB52_RS06575	COG1058	Belongs to the CinA family
GJB52_RS06595	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GJB52_RS06600	COG2137	regulation of response to DNA damage stimulus
GJB52_RS06610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GJB52_RS06615	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GJB52_RS06620	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GJB52_RS06625	COG2813	Specifically methylates the guanine in position
GJB52_RS06630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GJB52_RS06640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GJB52_RS06650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GJB52_RS06655	COG0131	Imidazoleglycerol-phosphate dehydratase
GJB52_RS06660	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GJB52_RS06665	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GJB52_RS06685	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GJB52_RS06690	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GJB52_RS06695	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GJB52_RS06700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GJB52_RS06710	COG2814	Major facilitator Superfamily
GJB52_RS06735	COG0318	PFAM AMP-dependent synthetase and ligase
GJB52_RS06755	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GJB52_RS06760	COG0072	phenylalanine-tRNA ligase activity
GJB52_RS06760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GJB52_RS06820	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GJB52_RS06825	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GJB52_RS06830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GJB52_RS06835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GJB52_RS06840	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GJB52_RS06845	COG1438	arginine binding
GJB52_RS06850	COG0137	argininosuccinate synthase activity
GJB52_RS06855	COG0165	Argininosuccinate lyase
GJB52_RS06875	COG2094	Belongs to the DNA glycosylase MPG family
GJB52_RS06880	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GJB52_RS06890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GJB52_RS06930	COG0647	UMP catabolic process
GJB52_RS06945	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GJB52_RS06950	COG0497	DNA recombination
GJB52_RS06955	COG0504	CTP synthase activity
GJB52_RS06960	COG0494	nUDIX hydrolase
GJB52_RS07000	COG1028	Short-chain dehydrogenase reductase Sdr
GJB52_RS07005	COG3387	PFAM Glycoside hydrolase 15-related
GJB52_RS07010	COG2816	NAD+ diphosphatase activity
GJB52_RS07025	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GJB52_RS07030	COG2079	MmgE PrpD family protein
GJB52_RS07050	COG3290	protein histidine kinase activity
GJB52_RS07055	COG1301	dicarboxylic acid transport
GJB52_RS07080	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GJB52_RS07085	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GJB52_RS07100	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GJB52_RS07110	COG1160	GTP binding
GJB52_RS07135	COG1960	acyl-CoA dehydrogenase activity
GJB52_RS07160	COG0509	glycine decarboxylation via glycine cleavage system
GJB52_RS07165	COG1716	ATPase activity
GJB52_RS07190	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GJB52_RS07190	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GJB52_RS07195	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GJB52_RS07210	COG1940	carbohydrate kinase activity
GJB52_RS07230	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GJB52_RS07235	COG1403	HNH endonuclease
GJB52_RS07245	COG2815	serine threonine protein kinase
GJB52_RS07245	COG0515	serine threonine protein kinase
GJB52_RS07260	COG0142	geranyltranstransferase activity
GJB52_RS07270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GJB52_RS07280	COG2001	Belongs to the MraZ family
GJB52_RS07285	COG0275	rRNA processing
GJB52_RS07295	COG0768	penicillin binding
GJB52_RS07310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GJB52_RS07315	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GJB52_RS07325	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GJB52_RS07330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GJB52_RS07335	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GJB52_RS07340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GJB52_RS07345	COG1496	oxidoreductase activity
GJB52_RS07355	COG1799	cell septum assembly
GJB52_RS07370	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GJB52_RS07380	COG0587	DNA-directed DNA polymerase activity
GJB52_RS07390	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GJB52_RS07395	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GJB52_RS07415	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GJB52_RS07420	COG0174	glutamine synthetase
GJB52_RS07425	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GJB52_RS07435	COG2066	Belongs to the glutaminase family
GJB52_RS07465	COG4974	Belongs to the 'phage' integrase family
GJB52_RS07485	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GJB52_RS07490	COG0321	lipoyl(octanoyl) transferase activity
GJB52_RS07500	COG4946	Tricorn protease homolog
GJB52_RS07500	COG0793	Belongs to the peptidase S41A family
GJB52_RS07515	COG0508	dehydrogenase complex catalyzes the overall conversion of
GJB52_RS07520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GJB52_RS07525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GJB52_RS07545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GJB52_RS07570	COG1271	oxidase subunit
GJB52_RS07575	COG1294	oxidase, subunit
GJB52_RS07580	COG4988	ABC transporter
GJB52_RS07595	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GJB52_RS07625	COG0756	dUTP diphosphatase activity
GJB52_RS07650	COG0569	domain protein
GJB52_RS07655	COG0531	amino acid
GJB52_RS07660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GJB52_RS07665	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GJB52_RS07670	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GJB52_RS07675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GJB52_RS07695	COG0667	Aldo Keto reductase
GJB52_RS07705	COG1024	Enoyl-CoA hydratase
GJB52_RS07705	COG1250	3-hydroxyacyl-CoA dehydrogenase
GJB52_RS07710	COG0183	Belongs to the thiolase family
GJB52_RS07715	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GJB52_RS07740	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GJB52_RS07755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GJB52_RS07780	COG2072	flavoprotein involved in K transport
GJB52_RS07830	COG0242	peptide deformylase activity
GJB52_RS07835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GJB52_RS07845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GJB52_RS07850	COG3201	nicotinamide mononucleotide transporter
GJB52_RS07865	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GJB52_RS07865	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GJB52_RS07870	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GJB52_RS07870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GJB52_RS07875	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GJB52_RS07880	COG0140	phosphoribosyl-ATP diphosphatase activity
GJB52_RS07885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GJB52_RS07890	COG0107	imidazoleglycerol-phosphate synthase activity
GJB52_RS07900	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GJB52_RS07920	COG0134	indole-3-glycerol-phosphate synthase activity
GJB52_RS07925	COG0133	tryptophan synthase activity
GJB52_RS07930	COG0159	tryptophan synthase activity
GJB52_RS07935	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GJB52_RS07940	COG0070	glutamate synthase
GJB52_RS07940	COG0069	glutamate synthase activity
GJB52_RS07940	COG0067	glutamate synthase
GJB52_RS07990	COG3654	unkown
GJB52_RS08000	COG0019	diaminopimelate decarboxylase activity
GJB52_RS08010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GJB52_RS08015	COG2261	transglycosylase associated protein
GJB52_RS08035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GJB52_RS08055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GJB52_RS08060	COG0667	Aldo Keto reductase
GJB52_RS08065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GJB52_RS08070	COG1121	(ABC) transporter
GJB52_RS08105	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GJB52_RS08110	COG0542	response to heat
GJB52_RS08125	COG0508	dehydrogenase complex catalyzes the overall conversion of
GJB52_RS08130	COG0022	dehydrogenase e1 component
GJB52_RS08135	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GJB52_RS08145	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GJB52_RS08150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GJB52_RS08155	COG1053	succinate dehydrogenase
GJB52_RS08220	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
GJB52_RS08255	COG1793	dna ligase
GJB52_RS08255	COG3285	dna ligase
GJB52_RS08265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GJB52_RS08265	COG0574	Belongs to the PEP-utilizing enzyme family
GJB52_RS08305	COG1063	alcohol dehydrogenase
GJB52_RS08315	COG0745	RESPONSE REGULATOR receiver
GJB52_RS08320	COG2205	protein histidine kinase activity
GJB52_RS08340	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GJB52_RS08360	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GJB52_RS08370	COG0589	response to stress
GJB52_RS08375	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GJB52_RS08385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GJB52_RS08405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GJB52_RS08415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GJB52_RS08430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GJB52_RS08460	COG1902	pentaerythritol trinitrate reductase activity
GJB52_RS08475	COG2130	NADP-dependent
GJB52_RS08495	COG2226	methyltransferase
GJB52_RS08510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GJB52_RS08515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GJB52_RS08525	COG2814	Major facilitator Superfamily
GJB52_RS08530	COG1028	Short-chain dehydrogenase reductase Sdr
GJB52_RS08535	COG3119	arylsulfatase activity
GJB52_RS08555	COG1846	Transcriptional regulator
GJB52_RS08555	COG1940	carbohydrate kinase activity
GJB52_RS08570	COG2268	Band 7 protein
GJB52_RS08605	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GJB52_RS08620	COG1902	pentaerythritol trinitrate reductase activity
GJB52_RS08670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GJB52_RS08675	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GJB52_RS08680	COG1643	Atp-dependent helicase
GJB52_RS08685	COG1028	Short-chain dehydrogenase reductase Sdr
GJB52_RS08690	COG0783	Belongs to the Dps family
GJB52_RS08695	COG0009	L-threonylcarbamoyladenylate synthase
GJB52_RS08700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GJB52_RS08735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GJB52_RS08745	COG1609	Transcriptional regulator
GJB52_RS08750	COG0673	inositol 2-dehydrogenase activity
GJB52_RS08770	COG0436	Aminotransferase
GJB52_RS08775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GJB52_RS08795	COG2050	protein possibly involved in aromatic compounds catabolism
GJB52_RS08820	COG0539	negative regulation of cytoplasmic translation
GJB52_RS08825	COG3152	Membrane
GJB52_RS08830	COG1739	Uncharacterized protein family UPF0029
GJB52_RS08835	COG0237	dephospho-CoA kinase activity
GJB52_RS08835	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GJB52_RS08845	COG0556	nucleotide-excision repair
GJB52_RS08865	COG4106	trans-aconitate 2-methyltransferase activity
GJB52_RS08875	COG3550	peptidyl-serine autophosphorylation
GJB52_RS08895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GJB52_RS08905	COG0546	phosphoglycolate phosphatase activity
GJB52_RS08915	COG0322	excinuclease ABC activity
GJB52_RS08920	COG1660	Displays ATPase and GTPase activities
GJB52_RS08930	COG1481	regulation of sporulation
GJB52_RS08940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GJB52_RS08945	COG0126	phosphoglycerate kinase activity
GJB52_RS08950	COG0149	triose-phosphate isomerase activity
GJB52_RS08955	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GJB52_RS08960	COG0363	glucosamine-6-phosphate deaminase activity
GJB52_RS08975	COG0166	Belongs to the GPI family
GJB52_RS08980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GJB52_RS08990	COG0109	protoheme IX farnesyltransferase activity
GJB52_RS09005	COG1131	(ABC) transporter
GJB52_RS09030	COG0396	ATPase activity
GJB52_RS09035	COG2151	metal-sulfur cluster biosynthetic enzyme
GJB52_RS09040	COG0318	PFAM AMP-dependent synthetase and ligase
GJB52_RS09045	COG0183	Belongs to the thiolase family
GJB52_RS09055	COG1122	ATPase activity
GJB52_RS09060	COG1268	BioY protein
GJB52_RS09065	COG0488	(ABC) transporter
GJB52_RS09090	COG1028	Short-chain dehydrogenase reductase Sdr
GJB52_RS09095	COG1028	Short-chain dehydrogenase reductase Sdr
GJB52_RS09100	COG0560	Phosphoserine phosphatase
GJB52_RS09100	COG3830	Belongs to the UPF0237 family
GJB52_RS09105	COG1119	ATPase activity
GJB52_RS09110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GJB52_RS09120	COG0254	rRNA binding
GJB52_RS09140	COG2855	membrane
GJB52_RS09150	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GJB52_RS09155	COG0297	glycogen (starch) synthase activity
GJB52_RS09160	COG1403	HNH endonuclease
GJB52_RS09190	COG1028	Short-chain dehydrogenase reductase Sdr
GJB52_RS09200	COG0477	Major facilitator Superfamily
GJB52_RS09230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GJB52_RS09250	COG0656	L-ascorbic acid biosynthetic process
GJB52_RS09255	COG1968	undecaprenyl-diphosphatase activity
GJB52_RS09260	COG0215	cysteine-tRNA ligase activity
GJB52_RS09270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GJB52_RS09285	COG1222	aaa ATPase
GJB52_RS09290	COG4122	O-methyltransferase activity
GJB52_RS09300	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GJB52_RS09305	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GJB52_RS09310	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GJB52_RS09335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GJB52_RS09340	COG0805	protein transport
GJB52_RS09345	COG4581	dead DEAH box helicase
GJB52_RS09355	COG1216	Glycosyl transferase, family 2
GJB52_RS09380	COG2364	Membrane
GJB52_RS09385	COG2226	methyltransferase
GJB52_RS09390	COG0242	peptide deformylase activity
GJB52_RS09395	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GJB52_RS09400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GJB52_RS09405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GJB52_RS09410	COG4974	Belongs to the 'phage' integrase family
GJB52_RS09460	COG0494	nUDIX hydrolase
GJB52_RS09475	COG0494	nUDIX hydrolase
GJB52_RS09505	COG4644	lycopene metabolic process
GJB52_RS09515	COG1129	ABC transporter
GJB52_RS09535	COG1522	sequence-specific DNA binding
GJB52_RS09540	COG3142	Participates in the control of copper homeostasis
GJB52_RS09545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GJB52_RS09550	COG1845	cytochrome c oxidase, subunit III
GJB52_RS09555	COG2010	Cytochrome c
GJB52_RS09560	COG0723	plastoquinol--plastocyanin reductase activity
GJB52_RS09565	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GJB52_RS09570	COG2188	Transcriptional regulator
GJB52_RS09585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GJB52_RS09590	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GJB52_RS09610	COG0667	Aldo Keto reductase
GJB52_RS09615	COG0167	dihydroorotate dehydrogenase activity
GJB52_RS09635	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GJB52_RS09640	COG1381	Involved in DNA repair and RecF pathway recombination
GJB52_RS09645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GJB52_RS09650	COG3590	peptidase
GJB52_RS09660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GJB52_RS09670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GJB52_RS09685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GJB52_RS09690	COG0484	heat shock protein binding
GJB52_RS09695	COG1420	regulation of RNA biosynthetic process
GJB52_RS09710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GJB52_RS09715	COG0481	GTPase activity
GJB52_RS09725	COG0268	Binds directly to 16S ribosomal RNA
GJB52_RS09745	COG1307	EDD domain protein, DegV family
GJB52_RS09750	COG0495	leucyl-tRNA aminoacylation
GJB52_RS09755	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GJB52_RS09760	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GJB52_RS09765	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GJB52_RS09770	COG2390	Transcriptional regulator
GJB52_RS09775	COG0656	L-ascorbic acid biosynthetic process
GJB52_RS09815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GJB52_RS09820	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GJB52_RS09830	COG1758	RNA polymerase activity
GJB52_RS09835	COG0194	GDP metabolic process
GJB52_RS09840	COG0194	GDP metabolic process
GJB52_RS09845	COG0284	orotidine-5'-phosphate decarboxylase activity
GJB52_RS09850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GJB52_RS09855	COG0505	Belongs to the CarA family
GJB52_RS09865	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GJB52_RS09870	COG0540	Belongs to the ATCase OTCase family
GJB52_RS09875	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GJB52_RS09885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GJB52_RS09890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GJB52_RS09900	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GJB52_RS09905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GJB52_RS09910	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GJB52_RS09915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GJB52_RS09920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GJB52_RS09925	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GJB52_RS09930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GJB52_RS09945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GJB52_RS09975	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GJB52_RS09980	COG0124	histidyl-tRNA synthetase
GJB52_RS09990	COG1196	nuclear chromosome segregation
GJB52_RS10000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GJB52_RS10005	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GJB52_RS10010	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GJB52_RS10025	COG0632	four-way junction helicase activity
GJB52_RS10030	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GJB52_RS10035	COG0217	transcriptional regulatory protein
GJB52_RS10040	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GJB52_RS10045	COG0367	asparagine synthase
GJB52_RS10055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GJB52_RS10065	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GJB52_RS10070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GJB52_RS10080	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GJB52_RS10085	COG0587	DNA-directed DNA polymerase activity
GJB52_RS10095	COG0456	acetyltransferase
GJB52_RS10100	COG1316	TRANSCRIPTIONal
GJB52_RS10110	COG2135	peptidase activity
GJB52_RS10145	COG0318	PFAM AMP-dependent synthetase and ligase
GJB52_RS10160	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GJB52_RS10165	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GJB52_RS10170	COG1780	Probably involved in ribonucleotide reductase function
GJB52_RS10185	COG0583	DNA-binding transcription factor activity
GJB52_RS10195	COG1012	belongs to the aldehyde dehydrogenase family
GJB52_RS10240	COG0714	Associated with various cellular activities
GJB52_RS10265	COG0586	Pfam SNARE associated Golgi protein
GJB52_RS10290	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GJB52_RS10315	COG0745	RESPONSE REGULATOR receiver
GJB52_RS10320	COG0671	phosphoesterase, PA-phosphatase related
GJB52_RS10325	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GJB52_RS10355	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GJB52_RS10360	COG3012	SEC-C Motif Domain Protein
GJB52_RS10385	COG0799	negative regulation of ribosome biogenesis
GJB52_RS10395	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GJB52_RS10405	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GJB52_RS10410	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GJB52_RS10415	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GJB52_RS10420	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GJB52_RS10425	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GJB52_RS10430	COG0351	phosphomethylpyrimidine kinase
GJB52_RS10430	COG0352	thiamine-phosphate diphosphorylase activity
GJB52_RS10430	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GJB52_RS10435	COG1530	ribonuclease E activity
GJB52_RS10445	COG0105	UTP biosynthetic process
GJB52_RS10455	COG0285	dihydrofolate synthase activity
GJB52_RS10460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GJB52_RS10470	COG3189	MarR family transcriptional regulator
GJB52_RS10480	COG0525	valine-tRNA ligase activity
GJB52_RS10495	COG0477	Major facilitator Superfamily
GJB52_RS10500	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GJB52_RS10505	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GJB52_RS10510	COG0740	serine-type endopeptidase activity
GJB52_RS10515	COG0740	serine-type endopeptidase activity
GJB52_RS10520	COG0544	peptidyl-prolyl cis-trans isomerase activity
GJB52_RS10540	COG0698	ribose 5-phosphate isomerase
GJB52_RS10565	COG0668	transmembrane transport
GJB52_RS10585	COG1946	Acyl-CoA thioesterase
GJB52_RS10610	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GJB52_RS10670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GJB52_RS10690	COG0629	single-stranded DNA binding
GJB52_RS10765	COG1401	restriction endodeoxyribonuclease activity
GJB52_RS10845	COG0477	Major facilitator Superfamily
GJB52_RS10850	COG0583	DNA-binding transcription factor activity
GJB52_RS10865	COG0702	epimerase
GJB52_RS10890	COG2409	Drug exporters of the RND superfamily
GJB52_RS10920	COG1022	Amp-dependent synthetase and ligase
GJB52_RS10930	COG0667	Aldo Keto reductase
GJB52_RS10955	COG5433	transposase activity
GJB52_RS10990	COG2217	Heavy metal translocating P-type atpase
GJB52_RS11020	COG3237	CsbD-like
GJB52_RS11025	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
GJB52_RS11035	COG2826	transposase and inactivated derivatives, IS30 family
GJB52_RS11040	COG0583	DNA-binding transcription factor activity
GJB52_RS11080	COG0438	transferase activity, transferring glycosyl groups
GJB52_RS11085	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GJB52_RS11105	COG2197	response regulator
GJB52_RS11110	COG1191	sigma factor activity
GJB52_RS11125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GJB52_RS11180	COG1012	belongs to the aldehyde dehydrogenase family
GJB52_RS11185	COG0473	3-isopropylmalate dehydrogenase activity
GJB52_RS11190	COG1250	3-hydroxyacyl-CoA dehydrogenase
GJB52_RS11200	COG0531	amino acid
GJB52_RS11210	COG1012	belongs to the aldehyde dehydrogenase family
GJB52_RS11240	COG1764	response to oxidative stress
GJB52_RS11245	COG1846	Transcriptional regulator
GJB52_RS11255	COG1064	alcohol dehydrogenase
GJB52_RS11265	COG4932	domain protein
GJB52_RS11265	COG5492	domain, Protein
GJB52_RS11275	COG2132	Multicopper oxidase
GJB52_RS11275	COG2132	Multicopper oxidase
GJB52_RS11285	COG5002	protein histidine kinase activity
GJB52_RS11290	COG0745	RESPONSE REGULATOR receiver
GJB52_RS11295	COG1937	Protein conserved in bacteria
GJB52_RS11320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GJB52_RS11330	COG0659	secondary active sulfate transmembrane transporter activity
GJB52_RS11335	COG0789	Transcriptional regulator
GJB52_RS11375	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GJB52_RS11380	COG1854	S-ribosylhomocysteine lyase activity
GJB52_RS11420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GJB52_RS11425	COG0798	PFAM Bile acid sodium symporter
GJB52_RS11440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GJB52_RS11460	COG0076	glutamate decarboxylase activity
GJB52_RS11465	COG2890	protein-(glutamine-N5) methyltransferase activity
GJB52_RS11520	COG0242	peptide deformylase activity
GJB52_RS11525	COG0477	Major facilitator Superfamily
GJB52_RS11535	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GJB52_RS11565	COG3022	response to hydroperoxide
GJB52_RS11575	COG2197	response regulator
GJB52_RS11580	COG4585	Histidine kinase
GJB52_RS11610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GJB52_RS11615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GJB52_RS11625	COG1045	serine acetyltransferase
GJB52_RS11630	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GJB52_RS11635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GJB52_RS11655	COG2176	DNA-directed DNA polymerase activity
GJB52_RS11680	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GJB52_RS11695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GJB52_RS11700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GJB52_RS11705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GJB52_RS11715	COG4974	Belongs to the 'phage' integrase family
GJB52_RS11725	COG0659	secondary active sulfate transmembrane transporter activity
GJB52_RS11735	COG0758	DNA mediated transformation
GJB52_RS11735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GJB52_RS11745	COG0792	nuclease activity
GJB52_RS11755	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GJB52_RS11765	COG0681	Belongs to the peptidase S26 family
GJB52_RS11770	COG0335	large ribosomal subunit rRNA binding
GJB52_RS11775	COG0336	Belongs to the RNA methyltransferase TrmD family
GJB52_RS11780	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GJB52_RS11785	COG1837	Belongs to the UPF0109 family
GJB52_RS11790	COG0228	four-way junction DNA binding
GJB52_RS11800	COG2514	catechol 2,3-dioxygenase activity
GJB52_RS11820	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GJB52_RS11845	COG0477	Major facilitator Superfamily
GJB52_RS11855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GJB52_RS11860	COG0318	PFAM AMP-dependent synthetase and ligase
GJB52_RS11865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GJB52_RS11890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GJB52_RS11895	COG0571	ribonuclease III activity
GJB52_RS11900	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GJB52_RS11910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GJB52_RS11920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GJB52_RS11925	COG0300	oxidoreductase activity
GJB52_RS11945	COG2268	Band 7 protein
GJB52_RS11950	COG0742	ribosomal rna small subunit methyltransferase
GJB52_RS11960	COG1461	Dihydroxyacetone kinase
GJB52_RS11980	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GJB52_RS11995	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GJB52_RS12000	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GJB52_RS12005	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GJB52_RS12025	COG2826	transposase and inactivated derivatives, IS30 family
GJB52_RS12035	COG1216	Glycosyl transferase, family 2
GJB52_RS12055	COG1216	Glycosyl transferase, family 2
GJB52_RS12065	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GJB52_RS12075	COG1388	LysM domain
GJB52_RS12075	COG1134	teichoic acid transport
GJB52_RS12095	COG1316	TRANSCRIPTIONal
GJB52_RS12105	COG2813	Specifically methylates the guanine in position
GJB52_RS12110	COG1181	Belongs to the D-alanine--D-alanine ligase family
GJB52_RS12115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GJB52_RS12125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GJB52_RS12135	COG0066	3-isopropylmalate dehydratase activity
GJB52_RS12140	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GJB52_RS12145	COG1414	Transcriptional regulator
GJB52_RS12180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GJB52_RS12190	COG0179	Fumarylacetoacetate (FAA) hydrolase
GJB52_RS12195	COG2116	formate transmembrane transporter activity
GJB52_RS12210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GJB52_RS12215	COG0473	3-isopropylmalate dehydrogenase activity
GJB52_RS12220	COG0415	Belongs to the DNA photolyase family
GJB52_RS12245	COG1562	ergosterol biosynthetic process
GJB52_RS12265	COG4585	Histidine kinase
GJB52_RS12270	COG2197	response regulator
GJB52_RS12280	COG1175	transmembrane transport
GJB52_RS12285	COG1653	transport
GJB52_RS12305	COG1136	(ABC) transporter
GJB52_RS12325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GJB52_RS12330	COG0440	acetolactate synthase activity
GJB52_RS12340	COG0129	dihydroxy-acid dehydratase activity
GJB52_RS12365	COG0747	negative chemotaxis
GJB52_RS12370	COG0579	oxidoreductase
GJB52_RS12375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GJB52_RS12390	COG2814	Major facilitator Superfamily
GJB52_RS12395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GJB52_RS12420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GJB52_RS12435	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GJB52_RS12445	COG3639	organic phosphonate transmembrane transporter activity
GJB52_RS12460	COG0179	Fumarylacetoacetate (FAA) hydrolase
GJB52_RS12490	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GJB52_RS12495	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GJB52_RS12505	COG1113	amino acid transport
GJB52_RS12540	COG0419	ATPase involved in DNA repair
GJB52_RS12545	COG0420	3'-5' exonuclease activity
GJB52_RS12550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GJB52_RS12560	COG2149	membrane
GJB52_RS12595	COG0586	Pfam SNARE associated Golgi protein
GJB52_RS12600	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GJB52_RS12605	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GJB52_RS12620	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GJB52_RS12630	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GJB52_RS12635	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GJB52_RS12640	COG1335	isochorismatase
GJB52_RS12655	COG0363	glucosamine-6-phosphate deaminase activity
GJB52_RS12670	COG3118	belongs to the thioredoxin family
GJB52_RS12680	COG0628	permease
GJB52_RS12695	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GJB52_RS12700	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GJB52_RS12715	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GJB52_RS12720	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GJB52_RS12730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GJB52_RS12735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GJB52_RS12740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GJB52_RS12745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GJB52_RS12750	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GJB52_RS12755	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GJB52_RS12760	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GJB52_RS12765	COG0356	it plays a direct role in the translocation of protons across the membrane
GJB52_RS12810	COG2890	protein-(glutamine-N5) methyltransferase activity
GJB52_RS12815	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GJB52_RS12825	COG0083	homoserine kinase activity
GJB52_RS12830	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GJB52_RS12835	COG0460	homoserine dehydrogenase
GJB52_RS12840	COG0019	diaminopimelate decarboxylase activity
GJB52_RS12845	COG0018	arginyl-trna synthetase
GJB52_RS12865	COG2723	6-phospho-beta-galactosidase activity
GJB52_RS12915	COG1643	Atp-dependent helicase
GJB52_RS12930	COG0318	PFAM AMP-dependent synthetase and ligase
GJB52_RS12935	COG0537	adenosine 5'-monophosphoramidase activity
GJB52_RS12940	COG1064	alcohol dehydrogenase
GJB52_RS12950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GJB52_RS12955	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GJB52_RS12975	COG1120	ATPase activity
GJB52_RS13005	COG3265	gluconokinase activity
GJB52_RS13010	COG3265	gluconokinase activity
GJB52_RS13015	COG4948	Mandelate Racemase Muconate Lactonizing
GJB52_RS13020	COG0246	Mannitol dehydrogenase
GJB52_RS13025	COG1904	glucuronate isomerase
GJB52_RS13030	COG1609	Transcriptional regulator
GJB52_RS13035	COG0673	inositol 2-dehydrogenase activity
GJB52_RS13045	COG0673	inositol 2-dehydrogenase activity
GJB52_RS13055	COG1609	Transcriptional regulator
GJB52_RS13065	COG1175	transmembrane transport
GJB52_RS13070	COG0395	ABC-type sugar transport system, permease component
GJB52_RS13080	COG0567	Dehydrogenase, E1 component
GJB52_RS13080	COG0508	dehydrogenase complex catalyzes the overall conversion of
GJB52_RS13140	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GJB52_RS13150	COG0483	inositol monophosphate 1-phosphatase activity
GJB52_RS13215	COG1472	Belongs to the glycosyl hydrolase 3 family
GJB52_RS13230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GJB52_RS13245	COG2177	Part of the ABC transporter FtsEX involved in
GJB52_RS13250	COG2884	Cell division ATP-binding protein ftsE
GJB52_RS13255	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GJB52_RS13295	COG0438	transferase activity, transferring glycosyl groups
GJB52_RS13340	COG0673	inositol 2-dehydrogenase activity
GJB52_RS13360	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GJB52_RS13365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GJB52_RS13375	COG1088	dTDP-glucose 4,6-dehydratase activity
GJB52_RS13400	COG1216	Glycosyl transferase, family 2
GJB52_RS13405	COG1216	Glycosyl transferase, family 2
GJB52_RS13445	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GJB52_RS13465	COG1216	Glycosyl transferase, family 2
GJB52_RS13475	COG1674	ftsk spoiiie
GJB52_RS13495	COG2902	Dehydrogenase
GJB52_RS13530	COG0653	protein targeting
GJB52_RS13535	COG3214	Protein conserved in bacteria
GJB52_RS13540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GJB52_RS13550	COG5401	PFAM Sporulation and spore germination
GJB52_RS13555	COG5002	protein histidine kinase activity
GJB52_RS13555	COG5000	phosphorelay sensor kinase activity
GJB52_RS13560	COG0745	RESPONSE REGULATOR receiver
GJB52_RS13580	COG0714	Associated with various cellular activities
GJB52_RS13605	COG4172	Belongs to the ABC transporter superfamily
GJB52_RS13610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GJB52_RS13615	COG0601	transmembrane transport
GJB52_RS13630	COG0482	sulfurtransferase activity
GJB52_RS13645	COG0302	gtp cyclohydrolase
GJB52_RS13655	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GJB52_RS13680	COG0484	heat shock protein binding
GJB52_RS13685	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GJB52_RS13695	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GJB52_RS13700	COG2086	electron transfer activity
GJB52_RS13705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GJB52_RS13715	COG1842	Phage shock protein A
GJB52_RS13720	COG0656	L-ascorbic acid biosynthetic process
GJB52_RS13730	COG0667	Aldo Keto reductase
GJB52_RS13740	COG3585	molybdate ion transport
GJB52_RS13785	COG0251	oxidation-reduction process
GJB52_RS13830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GJB52_RS13840	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GJB52_RS13845	COG0028	Belongs to the TPP enzyme family
GJB52_RS13860	COG1024	Enoyl-CoA hydratase
GJB52_RS13870	COG1024	Enoyl-CoA hydratase
GJB52_RS13885	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GJB52_RS13905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GJB52_RS13910	COG0318	PFAM AMP-dependent synthetase and ligase
GJB52_RS13915	COG1024	Enoyl-CoA hydratase
GJB52_RS13920	COG1250	3-hydroxyacyl-CoA dehydrogenase
GJB52_RS13920	COG1024	Enoyl-CoA hydratase
GJB52_RS13925	COG0183	Belongs to the thiolase family
GJB52_RS13930	COG1960	acyl-CoA dehydrogenase activity
GJB52_RS13935	COG1024	Enoyl-CoA hydratase
GJB52_RS13945	COG1028	Short-chain dehydrogenase reductase Sdr
GJB52_RS13950	COG0318	PFAM AMP-dependent synthetase and ligase
GJB52_RS13955	COG1024	Enoyl-CoA hydratase
GJB52_RS13970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GJB52_RS14000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GJB52_RS14010	COG1615	UPF0182 protein
GJB52_RS14015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GJB52_RS14055	COG0210	DNA helicase
GJB52_RS14075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GJB52_RS14080	COG0765	amino acid transport
GJB52_RS14100	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GJB52_RS14115	COG0181	hydroxymethylbilane synthase activity
GJB52_RS14120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GJB52_RS14125	COG3253	May function as heme-dependent peroxidase
GJB52_RS14135	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GJB52_RS14140	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GJB52_RS14170	COG2154	pterin-4-alpha-carbinolamine dehydratase
GJB52_RS14175	COG2022	thiamine diphosphate biosynthetic process
GJB52_RS14185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GJB52_RS14190	COG0352	thiamine-phosphate diphosphorylase activity
GJB52_RS14220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GJB52_RS14225	COG2072	flavoprotein involved in K transport
GJB52_RS14255	COG0842	Transport permease protein
GJB52_RS14255	COG1129	ABC transporter
GJB52_RS14295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GJB52_RS14295	COG2755	lipolytic protein G-D-S-L family
GJB52_RS14305	COG0006	proline dipeptidase activity
GJB52_RS14315	COG2239	Acts as a magnesium transporter
GJB52_RS14335	COG1595	DNA-templated transcription, initiation
GJB52_RS14340	COG4122	O-methyltransferase activity
GJB52_RS14355	COG0519	Catalyzes the synthesis of GMP from XMP
GJB52_RS14370	COG1126	abc transporter atp-binding protein
GJB52_RS14375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GJB52_RS14380	COG0765	amino acid transport
GJB52_RS14385	COG0765	amino acid transport
GJB52_RS14390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GJB52_RS14415	COG2171	N-acyltransferase activity
GJB52_RS14445	COG3226	Transcriptional regulator
GJB52_RS14485	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GJB52_RS14495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GJB52_RS14500	COG0601	transmembrane transport
GJB52_RS14510	COG1217	gtp-binding protein TYPA
GJB52_RS14515	COG4166	transmembrane transport
GJB52_RS14565	COG4221	oxidoreductase activity
GJB52_RS14575	COG3549	Plasmid maintenance system killer
GJB52_RS14595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GJB52_RS14600	COG0012	GTP binding
GJB52_RS14605	COG1322	Protein conserved in bacteria
GJB52_RS14610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GJB52_RS14620	COG1570	exodeoxyribonuclease VII activity
GJB52_RS14625	COG1722	exodeoxyribonuclease VII activity
GJB52_RS14630	COG2326	polyphosphate kinase activity
GJB52_RS14650	COG1609	Transcriptional regulator
GJB52_RS14655	COG2971	BadF BadG BcrA BcrD
GJB52_RS14665	COG2814	Major facilitator Superfamily
GJB52_RS14670	COG0626	cystathionine gamma-synthase activity
GJB52_RS14690	COG0598	Magnesium transport protein CorA
GJB52_RS14700	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GJB52_RS14710	COG0156	8-amino-7-oxononanoate synthase activity
GJB52_RS14715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GJB52_RS14720	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GJB52_RS14740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GJB52_RS14745	COG0477	Major facilitator Superfamily
GJB52_RS14750	COG0778	Nitroreductase
GJB52_RS14760	COG0039	L-malate dehydrogenase activity
GJB52_RS14770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GJB52_RS14775	COG1309	transcriptional regulator
GJB52_RS14780	COG1131	(ABC) transporter
GJB52_RS14785	COG3559	Exporter of polyketide antibiotics
GJB52_RS14795	COG0412	Dienelactone hydrolase
GJB52_RS14810	COG0488	(ABC) transporter
GJB52_RS14820	COG2217	Heavy metal translocating P-type atpase
GJB52_RS14835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GJB52_RS14845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GJB52_RS14850	COG0509	glycine decarboxylation via glycine cleavage system
GJB52_RS14855	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GJB52_RS14860	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GJB52_RS14860	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GJB52_RS14865	COG1113	amino acid transport
GJB52_RS14890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GJB52_RS14915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GJB52_RS14930	COG3711	transcriptional antiterminator
GJB52_RS14935	COG1263	PTS System
GJB52_RS14935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GJB52_RS14935	COG2190	(PTS) system
GJB52_RS14940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GJB52_RS14940	COG1263	PTS System
GJB52_RS14940	COG2190	(PTS) system
GJB52_RS14945	COG0135	phosphoribosylanthranilate isomerase activity
GJB52_RS15005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GJB52_RS15010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GJB52_RS15035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GJB52_RS15035	COG0519	Catalyzes the synthesis of GMP from XMP
GJB52_RS15055	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GJB52_RS15060	COG0516	GMP reductase activity
GJB52_RS15080	COG2217	Heavy metal translocating P-type atpase
GJB52_RS15085	COG0459	protein refolding
GJB52_RS15090	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GJB52_RS15095	COG1131	(ABC) transporter
GJB52_RS15105	COG4604	ABC transporter, ATP-binding protein
GJB52_RS15110	COG4605	iron ion homeostasis
GJB52_RS15115	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GJB52_RS15120	COG4607	ABC-type enterochelin transport system periplasmic component
GJB52_RS15130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GJB52_RS15135	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GJB52_RS15140	COG0671	phosphoesterase, PA-phosphatase related
GJB52_RS15145	COG0586	Pfam SNARE associated Golgi protein
GJB52_RS15155	COG5002	protein histidine kinase activity
GJB52_RS15160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GJB52_RS15175	COG0802	atpase or kinase
GJB52_RS15180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GJB52_RS15185	COG0438	transferase activity, transferring glycosyl groups
GJB52_RS15190	COG0366	Alpha amylase catalytic
GJB52_RS15205	COG1260	myo-inositol-1-phosphate synthase
GJB52_RS15210	COG0667	Aldo Keto reductase
GJB52_RS15225	COG0736	holo-[acyl-carrier-protein] synthase activity
GJB52_RS15230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GJB52_RS15235	COG1072	(Pantothenic acid kinase))
GJB52_RS15245	COG1970	mechanosensitive ion channel activity
GJB52_RS15250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GJB52_RS15255	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GJB52_RS15260	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GJB52_RS15265	COG0101	tRNA pseudouridine synthase activity
GJB52_RS15270	COG0203	ribosomal protein L17
GJB52_RS15275	COG0202	RNA polymerase activity
GJB52_RS15280	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GJB52_RS15285	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GJB52_RS15290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GJB52_RS15295	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GJB52_RS15300	COG3191	aminopeptidase activity
GJB52_RS15315	COG1175	transmembrane transport
GJB52_RS15320	COG0584	glycerophosphoryl diester phosphodiesterase
GJB52_RS15325	COG0024	Methionine aminopeptidase
GJB52_RS15330	COG0563	adenylate kinase activity
GJB52_RS15340	COG0200	Binds to the 23S rRNA
GJB52_RS15345	COG1841	ribosomal large subunit assembly
GJB52_RS15350	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GJB52_RS15360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GJB52_RS15365	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GJB52_RS15370	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GJB52_RS15375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GJB52_RS15380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GJB52_RS15385	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GJB52_RS15390	COG0255	Belongs to the universal ribosomal protein uL29 family
GJB52_RS15395	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GJB52_RS15400	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GJB52_RS15405	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GJB52_RS15410	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GJB52_RS15415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GJB52_RS15420	COG0089	rRNA binding
GJB52_RS15425	COG0088	Forms part of the polypeptide exit tunnel
GJB52_RS15430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GJB52_RS15435	COG0051	transcription antitermination factor activity, RNA binding
GJB52_RS15455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GJB52_RS15460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GJB52_RS15465	COG0049	tRNA binding
GJB52_RS15470	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GJB52_RS15475	COG1752	Esterase of the alpha-beta hydrolase superfamily
GJB52_RS15480	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GJB52_RS15485	COG0085	RNA polymerase activity
GJB52_RS15490	COG0183	Belongs to the thiolase family
GJB52_RS15495	COG0222	ribosome binding
GJB52_RS15500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GJB52_RS15515	COG0081	regulation of translation
GJB52_RS15520	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GJB52_RS15525	COG0250	Participates in transcription elongation, termination and antitermination
GJB52_RS15540	COG0436	Aminotransferase
GJB52_RS15545	COG2197	response regulator
GJB52_RS15585	COG0354	folic acid binding
GJB52_RS15590	COG3485	protocatechuate 3,4-dioxygenase
GJB52_RS15600	COG0745	RESPONSE REGULATOR receiver
GJB52_RS15605	COG0456	acetyltransferase
GJB52_RS15610	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GJB52_RS15630	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GJB52_RS15635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GJB52_RS15655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GJB52_RS15670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GJB52_RS15675	COG0738	Major facilitator superfamily
GJB52_RS15680	COG2030	dehydratase
GJB52_RS15685	COG2030	dehydratase
GJB52_RS15695	COG0477	Major facilitator Superfamily
GJB52_RS15710	COG2301	Belongs to the HpcH HpaI aldolase family
GJB52_RS15725	COG0025	NhaP-type Na H and K H
GJB52_RS15755	COG0477	Major facilitator Superfamily
GJB52_RS15775	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GJB52_RS15780	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GJB52_RS15785	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GJB52_RS15800	COG0402	S-adenosylhomocysteine deaminase activity
GJB52_RS15810	COG1652	LysM domain
GJB52_RS15825	COG4977	sequence-specific DNA binding
GJB52_RS15855	COG1012	belongs to the aldehyde dehydrogenase family
GJB52_RS15865	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GJB52_RS15880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GJB52_RS15885	COG2814	Major facilitator Superfamily
GJB52_RS15895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GJB52_RS15920	COG1666	GTP binding
GJB52_RS15930	COG2197	response regulator
GJB52_RS15935	COG4585	Histidine kinase
GJB52_RS15940	COG0406	alpha-ribazole phosphatase activity
GJB52_RS15945	COG0501	Belongs to the peptidase M48B family
GJB52_RS15960	COG0753	catalase activity
GJB52_RS15990	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GJB52_RS15995	COG0531	amino acid
GJB52_RS16020	COG0673	inositol 2-dehydrogenase activity
GJB52_RS16035	COG1012	belongs to the aldehyde dehydrogenase family
GJB52_RS16070	COG1648	precorrin-2 dehydrogenase activity
GJB52_RS16070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GJB52_RS16075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GJB52_RS16080	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GJB52_RS16120	COG2895	sulfate adenylyltransferase (ATP) activity
GJB52_RS16130	COG0175	sulfate reduction
GJB52_RS16135	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GJB52_RS16155	COG4152	abc transporter atp-binding protein
GJB52_RS16160	COG2860	membrane
GJB52_RS16185	COG0142	geranyltranstransferase activity
GJB52_RS16195	COG2226	methyltransferase
GJB52_RS16200	COG1169	isochorismate synthase
GJB52_RS16210	COG0765	amino acid transport
GJB52_RS16215	COG1126	abc transporter atp-binding protein
GJB52_RS16220	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GJB52_RS16225	COG4948	Mandelate Racemase Muconate Lactonizing
GJB52_RS16240	COG0508	dehydrogenase complex catalyzes the overall conversion of
GJB52_RS16260	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GJB52_RS16275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GJB52_RS16280	COG2151	metal-sulfur cluster biosynthetic enzyme
GJB52_RS16285	COG3396	Phenylacetate-CoA oxygenase
GJB52_RS16290	COG3460	Phenylacetate-CoA oxygenase
GJB52_RS16295	COG3396	Phenylacetate-CoA oxygenase
GJB52_RS16300	COG2050	protein possibly involved in aromatic compounds catabolism
GJB52_RS16320	COG1695	Transcriptional regulator
GJB52_RS16340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GJB52_RS16375	COG0110	maltose O-acetyltransferase activity
GJB52_RS16385	COG0789	Transcriptional regulator
GJB52_RS16415	COG1012	belongs to the aldehyde dehydrogenase family
GJB52_RS16415	COG2030	dehydratase
GJB52_RS16420	COG1250	3-hydroxyacyl-CoA dehydrogenase
GJB52_RS16425	COG1024	Enoyl-CoA hydratase
GJB52_RS16445	COG2211	Major facilitator Superfamily
GJB52_RS16450	COG0076	glutamate decarboxylase activity
GJB52_RS16455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GJB52_RS16460	COG0280	phosphate acetyltransferase
GJB52_RS16460	COG0857	belongs to the CobB CobQ family
GJB52_RS16505	COG0653	protein targeting
GJB52_RS16520	COG2365	Tyrosine phosphatase family
GJB52_RS16535	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GJB52_RS16565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GJB52_RS16570	COG1333	cytochrome c biogenesis protein
GJB52_RS16575	COG0785	Cytochrome C biogenesis protein
GJB52_RS16580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GJB52_RS16585	COG0406	alpha-ribazole phosphatase activity
GJB52_RS16600	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GJB52_RS16630	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GJB52_RS16640	COG1070	Carbohydrate kinase
GJB52_RS16645	COG3347	Dehydrogenase
GJB52_RS16645	COG1028	Short-chain dehydrogenase reductase Sdr
GJB52_RS16655	COG3254	rhamnose metabolic process
GJB52_RS16665	COG1879	ABC-type sugar transport system periplasmic component
GJB52_RS16675	COG1172	Belongs to the binding-protein-dependent transport system permease family
GJB52_RS16680	COG1129	ABC transporter
GJB52_RS16685	COG1609	Transcriptional regulator
GJB52_RS16690	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GJB52_RS16695	COG0640	Transcriptional regulator
GJB52_RS16700	COG0123	including yeast histone deacetylase and acetoin utilization protein
GJB52_RS16705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GJB52_RS16710	COG0569	domain protein
GJB52_RS16715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GJB52_RS16720	COG1595	DNA-templated transcription, initiation
GJB52_RS16725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GJB52_RS16725	COG2169	Transcriptional regulator
GJB52_RS16730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GJB52_RS16735	COG1082	Xylose isomerase domain protein TIM barrel
GJB52_RS16740	COG0248	Ppx GppA phosphatase
GJB52_RS16745	COG1754	DNA topoisomerase type I activity
GJB52_RS16745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GJB52_RS16755	COG2890	protein-(glutamine-N5) methyltransferase activity
GJB52_RS16760	COG1054	Belongs to the UPF0176 family
GJB52_RS16770	COG1205	dead DEAH box helicase
GJB52_RS16770	COG1111	helicase
GJB52_RS16830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GJB52_RS16840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GJB52_RS16845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GJB52_RS16875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GJB52_RS16880	COG1408	metallophosphoesterase
GJB52_RS16885	COG1132	(ABC) transporter
GJB52_RS16890	COG1132	(ABC) transporter
GJB52_RS16900	COG2824	Alkylphosphonate utilization operon protein PhnA
GJB52_RS16915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GJB52_RS16920	COG0151	Belongs to the GarS family
GJB52_RS16950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GJB52_RS16965	COG0542	response to heat
GJB52_RS16970	COG1063	alcohol dehydrogenase
GJB52_RS16980	COG2226	methyltransferase
GJB52_RS17015	COG3304	Inner membrane component domain
GJB52_RS17045	COG2197	response regulator
GJB52_RS17055	COG0475	glutathione-regulated potassium exporter activity
GJB52_RS17055	COG0569	domain protein
GJB52_RS17065	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GJB52_RS17075	COG1140	nitrate reductase beta subunit
GJB52_RS17095	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GJB52_RS17105	COG0395	ABC-type sugar transport system, permease component
GJB52_RS17110	COG1175	transmembrane transport
GJB52_RS17140	COG0789	Transcriptional regulator
GJB52_RS17145	COG0484	heat shock protein binding
GJB52_RS17150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GJB52_RS17155	COG0443	Heat shock 70 kDa protein
GJB52_RS17170	COG1280	lysine exporter protein (LysE YggA)
GJB52_RS17175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GJB52_RS17185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GJB52_RS17200	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GJB52_RS17205	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GJB52_RS17235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GJB52_RS17245	COG1122	ATPase activity
GJB52_RS17250	COG4721	ABC-type cobalt transport system, permease component
GJB52_RS17260	COG1320	monovalent cation:proton antiporter activity
GJB52_RS17265	COG2212	antiporter activity
GJB52_RS17275	COG0651	ATP synthesis coupled electron transport
GJB52_RS17280	COG1006	Multisubunit Na H antiporter MnhC subunit
GJB52_RS17285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GJB52_RS17285	COG2111	Na H antiporter
GJB52_RS17295	COG0717	Belongs to the dCTP deaminase family
GJB52_RS17305	COG0475	glutathione-regulated potassium exporter activity
GJB52_RS17345	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GJB52_RS17360	COG0433	COG0433 Predicted ATPase
GJB52_RS17375	COG1276	copper resistance
GJB52_RS17375	COG2372	response to copper ion
GJB52_RS17380	COG0776	regulation of translation
GJB52_RS17385	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GJB52_RS17390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GJB52_RS17395	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GJB52_RS17415	COG1132	(ABC) transporter
GJB52_RS17425	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GJB52_RS17430	COG2764	glyoxalase bleomycin resistance protein dioxygenase
GJB52_RS17440	COG1120	ATPase activity
GJB52_RS17445	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GJB52_RS17450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GJB52_RS17460	COG0435	Glutathione S-transferase
GJB52_RS17465	COG1125	glycine betaine transport
GJB52_RS17465	COG0517	IMP dehydrogenase activity
GJB52_RS17470	COG1174	glycine betaine transport
GJB52_RS17535	COG2378	regulation of single-species biofilm formation
GJB52_RS17540	COG1028	Short-chain dehydrogenase reductase Sdr
GJB52_RS17620	COG0745	RESPONSE REGULATOR receiver
GJB52_RS17645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GJB52_RS17650	COG1120	ATPase activity
GJB52_RS17670	COG0673	inositol 2-dehydrogenase activity
GJB52_RS17690	COG0686	Belongs to the AlaDH PNT family
GJB52_RS17705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GJB52_RS17725	COG0508	dehydrogenase complex catalyzes the overall conversion of
GJB52_RS17730	COG0022	dehydrogenase e1 component
GJB52_RS17740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GJB52_RS17745	COG1950	PFAM Membrane protein of
GJB52_RS17760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GJB52_RS17775	COG1607	acyl-coa hydrolase
GJB52_RS17780	COG0436	Aminotransferase
GJB52_RS17800	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GJB52_RS17810	COG0028	Belongs to the TPP enzyme family
GJB52_RS17830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GJB52_RS17840	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GJB52_RS17850	COG1937	Protein conserved in bacteria
GJB52_RS17875	COG0395	ABC-type sugar transport system, permease component
GJB52_RS17880	COG1175	transmembrane transport
GJB52_RS17885	COG1653	transport
GJB52_RS17890	COG4821	SIS domain
GJB52_RS17935	COG0359	binds to the 23S rRNA
GJB52_RS17940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GJB52_RS17950	COG0360	Binds together with S18 to 16S ribosomal RNA
GJB52_RS17965	COG1362	aminopeptidase activity
GJB52_RS17970	COG2197	response regulator
GJB52_RS17975	COG4585	Histidine kinase
GJB52_RS17995	COG1250	3-hydroxyacyl-CoA dehydrogenase
GJB52_RS18005	COG0738	Major facilitator superfamily
GJB52_RS18010	COG0488	(ABC) transporter
GJB52_RS18020	COG2197	response regulator
GJB52_RS18040	COG0577	efflux transmembrane transporter activity
GJB52_RS18065	COG0406	alpha-ribazole phosphatase activity
GJB52_RS18090	COG0492	ferredoxin-NADP+ reductase activity
GJB52_RS18095	COG3118	belongs to the thioredoxin family
GJB52_RS18120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GJB52_RS18145	COG1192	Involved in chromosome partitioning
GJB52_RS18150	COG0357	Ribosomal RNA small subunit methyltransferase G
GJB52_RS18160	COG0706	membrane insertase activity
GJB52_RS18165	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GJB52_RS18170	COG0594	ribonuclease P activity
GJB52_RS18175	COG0230	Belongs to the bacterial ribosomal protein bL34 family