locus-tag	class	description
F8G81_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F8G81_RS00010	COG0592	DNA-directed DNA polymerase activity
F8G81_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F8G81_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F8G81_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
F8G81_RS00030	COG0187	DNA topoisomerase II activity
F8G81_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F8G81_RS00040	COG3266	domain, Protein
F8G81_RS00065	COG1215	transferase activity, transferring glycosyl groups
F8G81_RS00080	COG0705	Rhomboid family
F8G81_RS00085	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F8G81_RS00090	COG2818	Glycosylase
F8G81_RS00100	COG3764	Sortase (surface protein transpeptidase)
F8G81_RS00110	COG0515	serine threonine protein kinase
F8G81_RS00115	COG0515	serine threonine protein kinase
F8G81_RS00120	COG0768	penicillin binding
F8G81_RS00135	COG1716	ATPase activity
F8G81_RS00140	COG1716	ATPase activity
F8G81_RS00150	COG0589	response to stress
F8G81_RS00155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8G81_RS00160	COG0747	negative chemotaxis
F8G81_RS00170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8G81_RS00175	COG0444	Belongs to the ABC transporter superfamily
F8G81_RS00180	COG4608	Belongs to the ABC transporter superfamily
F8G81_RS00190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8G81_RS00195	COG4948	Mandelate Racemase Muconate Lactonizing
F8G81_RS00200	COG0583	DNA-binding transcription factor activity
F8G81_RS00205	COG1609	Transcriptional regulator
F8G81_RS00220	COG4948	Mandelate Racemase Muconate Lactonizing
F8G81_RS00230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F8G81_RS00235	COG0583	DNA-binding transcription factor activity
F8G81_RS00255	COG0589	response to stress
F8G81_RS00290	COG1064	alcohol dehydrogenase
F8G81_RS00310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F8G81_RS00315	COG1984	allophanate hydrolase subunit 2
F8G81_RS00320	COG4770	biotin carboxylase activity
F8G81_RS00330	COG4336	lyase activity
F8G81_RS00335	COG1914	H( )-stimulated, divalent metal cation uptake system
F8G81_RS00355	COG2376	Dihydroxyacetone kinase
F8G81_RS00365	COG1175	transmembrane transport
F8G81_RS00370	COG0395	ABC-type sugar transport system, permease component
F8G81_RS00375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F8G81_RS00385	COG1414	Transcriptional regulator
F8G81_RS00390	COG3485	protocatechuate 3,4-dioxygenase
F8G81_RS00395	COG0667	Aldo Keto reductase
F8G81_RS00405	COG4214	carbohydrate transport
F8G81_RS00415	COG4213	ABC transporter substrate-binding protein
F8G81_RS00420	COG1414	Transcriptional regulator
F8G81_RS00435	COG0673	inositol 2-dehydrogenase activity
F8G81_RS00450	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F8G81_RS00460	COG0183	Belongs to the thiolase family
F8G81_RS00475	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS00495	COG1129	ABC transporter
F8G81_RS00505	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS00515	COG1454	alcohol dehydrogenase
F8G81_RS00520	COG1063	alcohol dehydrogenase
F8G81_RS00545	COG0833	amino acid
F8G81_RS00580	COG0277	FAD linked oxidase domain protein
F8G81_RS00590	COG1357	PFAM Pentapeptide repeats (8 copies)
F8G81_RS00600	COG2409	Drug exporters of the RND superfamily
F8G81_RS00630	COG1175	transmembrane transport
F8G81_RS00645	COG3534	alpha-L-arabinofuranosidase
F8G81_RS00655	COG1609	Transcriptional regulator
F8G81_RS00660	COG1162	GTPase activity
F8G81_RS00685	COG3321	synthase
F8G81_RS00685	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS00685	COG0604	alcohol dehydrogenase
F8G81_RS00705	COG3706	GGDEF domain
F8G81_RS00710	COG2814	Major facilitator Superfamily
F8G81_RS00715	COG0583	DNA-binding transcription factor activity
F8G81_RS00730	COG0395	ABC-type sugar transport system, permease component
F8G81_RS00735	COG4209	transmembrane transport
F8G81_RS00745	COG1609	Transcriptional regulator
F8G81_RS00750	COG0395	ABC-type sugar transport system, permease component
F8G81_RS00755	COG1175	transmembrane transport
F8G81_RS00760	COG1653	transport
F8G81_RS00780	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS00805	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8G81_RS00815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8G81_RS00825	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8G81_RS00845	COG0477	Major facilitator Superfamily
F8G81_RS00855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8G81_RS00885	COG2207	Transcriptional regulator
F8G81_RS00890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F8G81_RS00905	COG1733	regulation of RNA biosynthetic process
F8G81_RS00940	COG1733	regulation of RNA biosynthetic process
F8G81_RS00945	COG0702	epimerase
F8G81_RS00970	COG2197	response regulator
F8G81_RS00980	COG1595	DNA-templated transcription, initiation
F8G81_RS01000	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F8G81_RS01005	COG0673	inositol 2-dehydrogenase activity
F8G81_RS01015	COG0673	inositol 2-dehydrogenase activity
F8G81_RS01025	COG0659	secondary active sulfate transmembrane transporter activity
F8G81_RS01035	COG1609	Transcriptional regulator
F8G81_RS01050	COG0726	polysaccharide deacetylase
F8G81_RS01070	COG0346	lactoylglutathione lyase activity
F8G81_RS01080	COG1957	nucleoside hydrolase
F8G81_RS01085	COG0477	Major facilitator Superfamily
F8G81_RS01105	COG1595	DNA-templated transcription, initiation
F8G81_RS01135	COG0800	Aldolase
F8G81_RS01140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8G81_RS01145	COG4948	Mandelate Racemase Muconate Lactonizing
F8G81_RS01150	COG0395	ABC-type sugar transport system, permease component
F8G81_RS01155	COG1175	transmembrane transport
F8G81_RS01165	COG1940	carbohydrate kinase activity
F8G81_RS01195	COG0561	phosphatase activity
F8G81_RS01205	COG0584	glycerophosphoryl diester phosphodiesterase
F8G81_RS01225	COG2200	EAL domain
F8G81_RS01240	COG4106	trans-aconitate 2-methyltransferase activity
F8G81_RS01250	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS01255	COG1929	Belongs to the glycerate kinase type-1 family
F8G81_RS01270	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS01295	COG2233	PERMEase
F8G81_RS01300	COG0778	Nitroreductase
F8G81_RS01355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F8G81_RS01360	COG0492	ferredoxin-NADP+ reductase activity
F8G81_RS01370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F8G81_RS01380	COG2066	Belongs to the glutaminase family
F8G81_RS01400	COG5416	Lipopolysaccharide assembly protein A domain
F8G81_RS01420	COG0577	efflux transmembrane transporter activity
F8G81_RS01420	COG1136	(ABC) transporter
F8G81_RS01425	COG0577	efflux transmembrane transporter activity
F8G81_RS01425	COG1136	(ABC) transporter
F8G81_RS01435	COG3940	Belongs to the glycosyl hydrolase 43 family
F8G81_RS01440	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS01450	COG0833	amino acid
F8G81_RS01460	COG1414	Transcriptional regulator
F8G81_RS01475	COG0154	amidase activity
F8G81_RS01480	COG3340	Belongs to the peptidase S51 family
F8G81_RS01485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F8G81_RS01485	COG0425	Belongs to the sulfur carrier protein TusA family
F8G81_RS01500	COG1597	lipid kinase activity
F8G81_RS01505	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F8G81_RS01510	COG0561	phosphatase activity
F8G81_RS01520	COG0395	ABC-type sugar transport system, permease component
F8G81_RS01525	COG1175	transmembrane transport
F8G81_RS01535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8G81_RS01585	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
F8G81_RS01605	COG2197	response regulator
F8G81_RS01640	COG0037	tRNA processing
F8G81_RS01650	COG1621	beta-fructofuranosidase activity
F8G81_RS01675	COG0395	ABC-type sugar transport system, permease component
F8G81_RS01685	COG1609	Transcriptional regulator
F8G81_RS01690	COG1621	beta-fructofuranosidase activity
F8G81_RS01695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F8G81_RS01700	COG0302	gtp cyclohydrolase
F8G81_RS01705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F8G81_RS01710	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F8G81_RS01740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F8G81_RS01745	COG3387	PFAM Glycoside hydrolase 15-related
F8G81_RS01765	COG0693	protein deglycase activity
F8G81_RS01770	COG2814	Major facilitator Superfamily
F8G81_RS01790	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F8G81_RS01810	COG1506	peptidase
F8G81_RS01810	COG0823	Involved in the tonB-independent uptake of proteins
F8G81_RS01815	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F8G81_RS01825	COG2376	Dihydroxyacetone kinase
F8G81_RS01830	COG1461	Dihydroxyacetone kinase
F8G81_RS01875	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
F8G81_RS01880	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F8G81_RS01885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F8G81_RS01905	COG1126	abc transporter atp-binding protein
F8G81_RS01910	COG0765	amino acid transport
F8G81_RS01915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8G81_RS01920	COG1802	Transcriptional regulator
F8G81_RS01930	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F8G81_RS01940	COG1126	abc transporter atp-binding protein
F8G81_RS01945	COG0765	amino acid transport
F8G81_RS01960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8G81_RS01965	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS01970	COG0473	3-isopropylmalate dehydrogenase activity
F8G81_RS01995	COG1063	alcohol dehydrogenase
F8G81_RS02000	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F8G81_RS02010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F8G81_RS02055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F8G81_RS02070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F8G81_RS02075	COG0306	phosphate transporter
F8G81_RS02100	COG1609	Transcriptional regulator
F8G81_RS02105	COG1172	Belongs to the binding-protein-dependent transport system permease family
F8G81_RS02110	COG1172	Belongs to the binding-protein-dependent transport system permease family
F8G81_RS02120	COG1879	ABC-type sugar transport system periplasmic component
F8G81_RS02135	COG2160	L-arabinose isomerase activity
F8G81_RS02155	COG1609	Transcriptional regulator
F8G81_RS02175	COG0831	urea catabolic process
F8G81_RS02180	COG0832	Belongs to the urease beta subunit family
F8G81_RS02185	COG0804	urea catabolic process
F8G81_RS02190	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
F8G81_RS02195	COG0830	nickel cation binding
F8G81_RS02200	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F8G81_RS02205	COG0829	nickel cation binding
F8G81_RS02210	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
F8G81_RS02245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8G81_RS02275	COG1621	beta-fructofuranosidase activity
F8G81_RS02285	COG0247	lactate metabolic process
F8G81_RS02285	COG0277	FAD linked oxidase domain protein
F8G81_RS02290	COG0583	DNA-binding transcription factor activity
F8G81_RS02310	COG2890	protein-(glutamine-N5) methyltransferase activity
F8G81_RS02330	COG2261	transglycosylase associated protein
F8G81_RS02340	COG3401	FG-GAP repeat protein
F8G81_RS02350	COG0667	Aldo Keto reductase
F8G81_RS02355	COG0656	L-ascorbic acid biosynthetic process
F8G81_RS02370	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
F8G81_RS02370	COG4124	Belongs to the glycosyl hydrolase 26 family
F8G81_RS02385	COG3360	Dodecin
F8G81_RS02390	COG0395	ABC-type sugar transport system, permease component
F8G81_RS02395	COG1175	transmembrane transport
F8G81_RS02400	COG1653	transport
F8G81_RS02415	COG1609	Transcriptional regulator
F8G81_RS02430	COG2084	Dehydrogenase
F8G81_RS02435	COG2610	gluconate transmembrane transporter activity
F8G81_RS02475	COG0076	glutamate decarboxylase activity
F8G81_RS02480	COG3486	L-lysine 6-monooxygenase (NADPH) activity
F8G81_RS02495	COG0300	oxidoreductase activity
F8G81_RS02505	COG0477	Major facilitator Superfamily
F8G81_RS02525	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
F8G81_RS02535	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F8G81_RS02560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8G81_RS02560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8G81_RS02560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8G81_RS02570	COG1349	DNA-binding transcription factor activity
F8G81_RS02590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F8G81_RS02605	COG1131	(ABC) transporter
F8G81_RS02620	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F8G81_RS02630	COG2733	membrane
F8G81_RS02635	COG0584	glycerophosphoryl diester phosphodiesterase
F8G81_RS02695	COG4122	O-methyltransferase activity
F8G81_RS02700	COG3237	CsbD-like
F8G81_RS02710	COG1295	ribonuclease BN
F8G81_RS02745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F8G81_RS02750	COG0859	PFAM glycosyl transferase family 9
F8G81_RS02760	COG0297	glycogen (starch) synthase activity
F8G81_RS02765	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F8G81_RS02770	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F8G81_RS02770	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F8G81_RS02775	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS02785	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS02790	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F8G81_RS02790	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F8G81_RS02810	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS02820	COG0745	RESPONSE REGULATOR receiver
F8G81_RS02830	COG1476	TRANSCRIPTIONal
F8G81_RS02835	COG3321	synthase
F8G81_RS02835	COG0604	alcohol dehydrogenase
F8G81_RS02835	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS02840	COG2186	Transcriptional regulator
F8G81_RS02860	COG0596	Alpha beta hydrolase
F8G81_RS02870	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F8G81_RS02895	COG1175	transmembrane transport
F8G81_RS02905	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS02910	COG0589	response to stress
F8G81_RS02930	COG3290	protein histidine kinase activity
F8G81_RS02935	COG4565	transcriptional regulatory protein
F8G81_RS02945	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
F8G81_RS02960	COG2252	PERMEase
F8G81_RS02980	COG3848	Pyruvate phosphate dikinase
F8G81_RS02980	COG0574	Belongs to the PEP-utilizing enzyme family
F8G81_RS03000	COG3883	PFAM NLP P60 protein
F8G81_RS03000	COG0791	NLP P60 protein
F8G81_RS03010	COG3220	belongs to the UPF0276 family
F8G81_RS03035	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F8G81_RS03035	COG1796	DNA polymerase
F8G81_RS03070	COG1609	Transcriptional regulator
F8G81_RS03080	COG0601	transmembrane transport
F8G81_RS03085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8G81_RS03090	COG0444	Belongs to the ABC transporter superfamily
F8G81_RS03095	COG4608	Belongs to the ABC transporter superfamily
F8G81_RS03115	COG2409	Drug exporters of the RND superfamily
F8G81_RS03165	COG0366	Alpha amylase catalytic
F8G81_RS03190	COG1609	Transcriptional regulator
F8G81_RS03210	COG1024	Enoyl-CoA hydratase
F8G81_RS03225	COG0492	ferredoxin-NADP+ reductase activity
F8G81_RS03235	COG0586	Pfam SNARE associated Golgi protein
F8G81_RS03245	COG1960	acyl-CoA dehydrogenase activity
F8G81_RS03275	COG1278	Cold shock
F8G81_RS03285	COG4948	Mandelate Racemase Muconate Lactonizing
F8G81_RS03295	COG1175	transmembrane transport
F8G81_RS03315	COG2197	response regulator
F8G81_RS03320	COG4585	Histidine kinase
F8G81_RS03335	COG0183	Belongs to the thiolase family
F8G81_RS03345	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F8G81_RS03365	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F8G81_RS03400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F8G81_RS03400	COG0357	Ribosomal RNA small subunit methyltransferase G
F8G81_RS03405	COG0191	fructose-bisphosphate aldolase activity
F8G81_RS03420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F8G81_RS03425	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F8G81_RS03455	COG0395	ABC-type sugar transport system, permease component
F8G81_RS03460	COG3622	Belongs to the hyi family
F8G81_RS03465	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
F8G81_RS03490	COG0673	inositol 2-dehydrogenase activity
F8G81_RS03510	COG1940	carbohydrate kinase activity
F8G81_RS03515	COG0673	inositol 2-dehydrogenase activity
F8G81_RS03525	COG0477	Major facilitator Superfamily
F8G81_RS03535	COG1595	DNA-templated transcription, initiation
F8G81_RS03545	COG1832	CoA-binding protein
F8G81_RS03555	COG2315	Protein conserved in bacteria
F8G81_RS03560	COG4762	Protein conserved in bacteria
F8G81_RS03580	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F8G81_RS03585	COG0047	phosphoribosylformylglycinamidine synthase activity
F8G81_RS03590	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F8G81_RS03620	COG1846	Transcriptional regulator
F8G81_RS03655	COG0519	Catalyzes the synthesis of GMP from XMP
F8G81_RS03660	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F8G81_RS03675	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F8G81_RS03675	COG3323	Protein of unknown function (DUF1653)
F8G81_RS03700	COG0741	lytic transglycosylase activity
F8G81_RS03700	COG1196	nuclear chromosome segregation
F8G81_RS03700	COG0739	heme binding
F8G81_RS03705	COG0386	Belongs to the glutathione peroxidase family
F8G81_RS03710	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F8G81_RS03715	COG0438	transferase activity, transferring glycosyl groups
F8G81_RS03735	COG1309	transcriptional regulator
F8G81_RS03745	COG0438	transferase activity, transferring glycosyl groups
F8G81_RS03765	COG0673	inositol 2-dehydrogenase activity
F8G81_RS03775	COG1940	carbohydrate kinase activity
F8G81_RS03780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8G81_RS03785	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F8G81_RS03795	COG1396	sequence-specific DNA binding
F8G81_RS03810	COG2205	protein histidine kinase activity
F8G81_RS03815	COG0745	RESPONSE REGULATOR receiver
F8G81_RS03820	COG0477	Major facilitator Superfamily
F8G81_RS03835	COG1309	transcriptional regulator
F8G81_RS03845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8G81_RS03850	COG1940	carbohydrate kinase activity
F8G81_RS03860	COG1175	transmembrane transport
F8G81_RS03865	COG0395	ABC-type sugar transport system, permease component
F8G81_RS03870	COG1940	carbohydrate kinase activity
F8G81_RS03875	COG0366	Alpha amylase catalytic
F8G81_RS03885	COG0343	queuine tRNA-ribosyltransferase activity
F8G81_RS03915	COG3842	ATPase activity
F8G81_RS03940	COG1960	acyl-CoA dehydrogenase activity
F8G81_RS03960	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F8G81_RS03980	COG0564	pseudouridine synthase activity
F8G81_RS04000	COG2364	Membrane
F8G81_RS04005	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F8G81_RS04010	COG1201	RNA secondary structure unwinding
F8G81_RS04015	COG0723	plastoquinol--plastocyanin reductase activity
F8G81_RS04040	COG2070	2-Nitropropane dioxygenase
F8G81_RS04055	COG2268	Band 7 protein
F8G81_RS04075	COG0438	transferase activity, transferring glycosyl groups
F8G81_RS04085	COG0671	phosphoesterase, PA-phosphatase related
F8G81_RS04090	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F8G81_RS04110	COG2205	protein histidine kinase activity
F8G81_RS04115	COG0745	RESPONSE REGULATOR receiver
F8G81_RS04125	COG2062	phosphohistidine phosphatase, SixA
F8G81_RS04130	COG0583	DNA-binding transcription factor activity
F8G81_RS04135	COG0697	spore germination
F8G81_RS04145	COG1309	transcriptional regulator
F8G81_RS04150	COG1511	domain protein
F8G81_RS04170	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
F8G81_RS04175	COG1017	nitric oxide dioxygenase activity
F8G81_RS04175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F8G81_RS04190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F8G81_RS04195	COG0514	ATP-dependent DNA helicase (RecQ)
F8G81_RS04210	COG1505	serine-type exopeptidase activity
F8G81_RS04230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8G81_RS04245	COG0604	alcohol dehydrogenase
F8G81_RS04245	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS04245	COG3321	synthase
F8G81_RS04255	COG1136	(ABC) transporter
F8G81_RS04255	COG0577	efflux transmembrane transporter activity
F8G81_RS04285	COG0656	L-ascorbic acid biosynthetic process
F8G81_RS04310	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F8G81_RS04315	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F8G81_RS04335	COG0588	phosphoglycerate mutase activity
F8G81_RS04345	COG5002	protein histidine kinase activity
F8G81_RS04365	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F8G81_RS04370	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F8G81_RS04375	COG0215	cysteine-tRNA ligase activity
F8G81_RS04380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F8G81_RS04405	COG0366	Alpha amylase catalytic
F8G81_RS04415	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F8G81_RS04440	COG1609	Transcriptional regulator
F8G81_RS04445	COG0366	Alpha amylase catalytic
F8G81_RS04450	COG0277	FAD linked oxidase domain protein
F8G81_RS04460	COG3842	ATPase activity
F8G81_RS04470	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
F8G81_RS04510	COG2957	Belongs to the agmatine deiminase family
F8G81_RS04520	COG0783	Belongs to the Dps family
F8G81_RS04535	COG0477	Major facilitator Superfamily
F8G81_RS04545	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F8G81_RS04545	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F8G81_RS04550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F8G81_RS04555	COG0509	glycine decarboxylation via glycine cleavage system
F8G81_RS04605	COG1278	Cold shock
F8G81_RS04615	COG0459	protein refolding
F8G81_RS04630	COG0328	RNA-DNA hybrid ribonuclease activity
F8G81_RS04640	COG2205	protein histidine kinase activity
F8G81_RS04645	COG0745	RESPONSE REGULATOR receiver
F8G81_RS04665	COG1278	Cold shock
F8G81_RS04685	COG0739	heme binding
F8G81_RS04690	COG3103	Sh3 type 3 domain protein
F8G81_RS04690	COG0791	NLP P60 protein
F8G81_RS04690	COG1388	LysM domain
F8G81_RS04705	COG0746	molybdenum cofactor guanylyltransferase activity
F8G81_RS04715	COG0303	'Molybdopterin
F8G81_RS04720	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F8G81_RS04740	COG0488	(ABC) transporter
F8G81_RS04745	COG1132	(ABC) transporter
F8G81_RS04750	COG0494	nUDIX hydrolase
F8G81_RS04780	COG0483	inositol monophosphate 1-phosphatase activity
F8G81_RS04790	COG1819	glycosyl
F8G81_RS04800	COG0045	succinate-CoA ligase (ADP-forming) activity
F8G81_RS04815	COG0640	Transcriptional regulator
F8G81_RS04825	COG2814	Major facilitator Superfamily
F8G81_RS04830	COG1942	4-Oxalocrotonate Tautomerase
F8G81_RS04835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8G81_RS04845	COG3962	Belongs to the TPP enzyme family
F8G81_RS04860	COG0673	inositol 2-dehydrogenase activity
F8G81_RS04865	COG1082	Xylose isomerase domain protein TIM barrel
F8G81_RS04895	COG1172	Belongs to the binding-protein-dependent transport system permease family
F8G81_RS04905	COG0673	inositol 2-dehydrogenase activity
F8G81_RS04910	COG0673	inositol 2-dehydrogenase activity
F8G81_RS04925	COG0673	inositol 2-dehydrogenase activity
F8G81_RS04930	COG3718	enzyme involved in inositol metabolism
F8G81_RS04935	COG2188	Transcriptional regulator
F8G81_RS04965	COG1396	sequence-specific DNA binding
F8G81_RS04980	COG0028	Belongs to the TPP enzyme family
F8G81_RS05015	COG1401	restriction endodeoxyribonuclease activity
F8G81_RS05025	COG5002	protein histidine kinase activity
F8G81_RS05030	COG0745	RESPONSE REGULATOR receiver
F8G81_RS05065	COG1902	pentaerythritol trinitrate reductase activity
F8G81_RS05110	COG0833	amino acid
F8G81_RS05115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8G81_RS05130	COG3583	domain protein
F8G81_RS05140	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F8G81_RS05145	COG0366	Alpha amylase catalytic
F8G81_RS05145	COG3103	Sh3 type 3 domain protein
F8G81_RS05150	COG2353	YceI-like domain
F8G81_RS05155	COG1254	Belongs to the acylphosphatase family
F8G81_RS05200	COG0477	Major facilitator Superfamily
F8G81_RS05215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F8G81_RS05220	COG1914	H( )-stimulated, divalent metal cation uptake system
F8G81_RS05235	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS05240	COG0395	ABC-type sugar transport system, permease component
F8G81_RS05245	COG1175	transmembrane transport
F8G81_RS05255	COG3684	Belongs to the aldolase LacD family
F8G81_RS05265	COG0673	inositol 2-dehydrogenase activity
F8G81_RS05285	COG4209	transmembrane transport
F8G81_RS05290	COG0395	ABC-type sugar transport system, permease component
F8G81_RS05335	COG2267	carboxylic ester hydrolase activity
F8G81_RS05350	COG0531	amino acid
F8G81_RS05370	COG1609	Transcriptional regulator
F8G81_RS05375	COG1472	Belongs to the glycosyl hydrolase 3 family
F8G81_RS05380	COG0673	inositol 2-dehydrogenase activity
F8G81_RS05395	COG1609	Transcriptional regulator
F8G81_RS05465	COG2318	DinB family
F8G81_RS05480	COG2135	peptidase activity
F8G81_RS05495	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F8G81_RS05515	COG2814	Major facilitator Superfamily
F8G81_RS05520	COG0667	Aldo Keto reductase
F8G81_RS05535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F8G81_RS05550	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F8G81_RS05565	COG2814	Major facilitator Superfamily
F8G81_RS05615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F8G81_RS05625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F8G81_RS05655	COG2814	Major facilitator Superfamily
F8G81_RS05660	COG1846	Transcriptional regulator
F8G81_RS05665	COG3548	integral membrane protein
F8G81_RS05765	COG1309	transcriptional regulator
F8G81_RS05775	COG1253	flavin adenine dinucleotide binding
F8G81_RS05800	COG2354	Protein conserved in bacteria
F8G81_RS05810	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F8G81_RS05910	COG0028	Belongs to the TPP enzyme family
F8G81_RS05920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F8G81_RS05925	COG1113	amino acid transport
F8G81_RS05965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F8G81_RS05975	COG1201	RNA secondary structure unwinding
F8G81_RS05980	COG0210	DNA helicase
F8G81_RS06000	COG1074	ATP-dependent DNA helicase activity
F8G81_RS06050	COG2267	carboxylic ester hydrolase activity
F8G81_RS06060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F8G81_RS06070	COG0183	Belongs to the thiolase family
F8G81_RS06075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F8G81_RS06085	COG1024	Enoyl-CoA hydratase
F8G81_RS06125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8G81_RS06130	COG4585	Histidine kinase
F8G81_RS06180	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
F8G81_RS06190	COG1309	transcriptional regulator
F8G81_RS06195	COG3540	Alkaline phosphatase
F8G81_RS06215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F8G81_RS06255	COG1278	Cold shock
F8G81_RS06265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F8G81_RS06275	COG3265	gluconokinase activity
F8G81_RS06280	COG2610	gluconate transmembrane transporter activity
F8G81_RS06320	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F8G81_RS06340	COG3300	MHYT domain
F8G81_RS06340	COG5001	Diguanylate cyclase
F8G81_RS06345	COG2261	transglycosylase associated protein
F8G81_RS06350	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F8G81_RS06365	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
F8G81_RS06400	COG0477	Major facilitator Superfamily
F8G81_RS06405	COG0138	bifunctional purine biosynthesis protein purh
F8G81_RS06415	COG1116	anion transmembrane transporter activity
F8G81_RS06420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8G81_RS06440	COG2838	Isocitrate dehydrogenase
F8G81_RS06450	COG0515	serine threonine protein kinase
F8G81_RS06465	COG0673	inositol 2-dehydrogenase activity
F8G81_RS06480	COG0531	amino acid
F8G81_RS06510	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F8G81_RS06515	COG1131	(ABC) transporter
F8G81_RS06540	COG0180	Tryptophanyl-tRNA synthetase
F8G81_RS06565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F8G81_RS06580	COG2009	succinate dehydrogenase
F8G81_RS06590	COG1473	amidohydrolase
F8G81_RS06590	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F8G81_RS06595	COG1846	Transcriptional regulator
F8G81_RS06600	COG1764	response to oxidative stress
F8G81_RS06605	COG2130	NADP-dependent
F8G81_RS06610	COG1744	ABC transporter substrate-binding protein PnrA-like
F8G81_RS06615	COG3845	ABC transporter
F8G81_RS06620	COG4603	Belongs to the binding-protein-dependent transport system permease family
F8G81_RS06625	COG1079	Belongs to the binding-protein-dependent transport system permease family
F8G81_RS06650	COG0586	Pfam SNARE associated Golgi protein
F8G81_RS06655	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F8G81_RS06660	COG3956	TIGRFAM MazG family protein
F8G81_RS06665	COG0148	phosphopyruvate hydratase activity
F8G81_RS06690	COG1252	NADH dehydrogenase
F8G81_RS06735	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F8G81_RS06745	COG1349	DNA-binding transcription factor activity
F8G81_RS06750	COG2017	converts alpha-aldose to the beta-anomer
F8G81_RS06760	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F8G81_RS06770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F8G81_RS06780	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F8G81_RS06790	COG1331	Highly conserved protein containing a thioredoxin domain
F8G81_RS06800	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F8G81_RS06805	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F8G81_RS06835	COG0114	fumarate hydratase activity
F8G81_RS06840	COG0288	reversible hydration of carbon dioxide
F8G81_RS06850	COG1494	fructose-1,6-bisphosphatase
F8G81_RS06865	COG1482	cell wall glycoprotein biosynthetic process
F8G81_RS06875	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F8G81_RS06925	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F8G81_RS06930	COG1376	ErfK ybiS ycfS ynhG family protein
F8G81_RS06980	COG0714	Associated with various cellular activities
F8G81_RS06985	COG0084	hydrolase, TatD family'
F8G81_RS06990	COG3583	domain protein
F8G81_RS06995	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F8G81_RS07000	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F8G81_RS07005	COG0488	(ABC) transporter
F8G81_RS07020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F8G81_RS07030	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F8G81_RS07035	COG0193	aminoacyl-tRNA hydrolase activity
F8G81_RS07055	COG0822	iron-sulfur transferase activity
F8G81_RS07060	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F8G81_RS07075	COG0702	epimerase
F8G81_RS07085	COG1988	membrane-bound metal-dependent
F8G81_RS07105	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F8G81_RS07110	COG0446	pyridine nucleotide-disulphide oxidoreductase
F8G81_RS07125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F8G81_RS07135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F8G81_RS07140	COG1959	2 iron, 2 sulfur cluster binding
F8G81_RS07165	COG0243	molybdopterin cofactor binding
F8G81_RS07170	COG2223	nitrite transmembrane transporter activity
F8G81_RS07175	COG0477	Major facilitator Superfamily
F8G81_RS07190	COG4770	biotin carboxylase activity
F8G81_RS07195	COG0424	maF-like protein
F8G81_RS07205	COG1823	symporter activity
F8G81_RS07220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F8G81_RS07225	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS07230	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F8G81_RS07230	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F8G81_RS07255	COG0714	Associated with various cellular activities
F8G81_RS07275	COG0631	protein serine/threonine phosphatase activity
F8G81_RS07295	COG1674	ftsk spoiiie
F8G81_RS07310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F8G81_RS07315	COG0483	inositol monophosphate 1-phosphatase activity
F8G81_RS07325	COG0251	oxidation-reduction process
F8G81_RS07330	COG4565	transcriptional regulatory protein
F8G81_RS07335	COG3290	protein histidine kinase activity
F8G81_RS07340	COG2851	Citrate transporter
F8G81_RS07345	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F8G81_RS07350	COG0154	amidase activity
F8G81_RS07355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F8G81_RS07365	COG0583	DNA-binding transcription factor activity
F8G81_RS07370	COG1063	alcohol dehydrogenase
F8G81_RS07375	COG0156	8-amino-7-oxononanoate synthase activity
F8G81_RS07385	COG1228	amidohydrolase
F8G81_RS07410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F8G81_RS07430	COG0400	carboxylic ester hydrolase activity
F8G81_RS07445	COG0423	glycine-tRNA ligase activity
F8G81_RS07475	COG0358	DNA primase activity
F8G81_RS07500	COG2814	Major facilitator Superfamily
F8G81_RS07520	COG0438	transferase activity, transferring glycosyl groups
F8G81_RS07560	COG2189	Belongs to the N(4) N(6)-methyltransferase family
F8G81_RS07645	COG0052	Belongs to the universal ribosomal protein uS2 family
F8G81_RS07650	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F8G81_RS07655	COG0528	UMP kinase activity
F8G81_RS07660	COG0233	cytoplasmic translational termination
F8G81_RS07675	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F8G81_RS07690	COG3275	phosphorelay sensor kinase activity
F8G81_RS07700	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F8G81_RS07720	COG0456	acetyltransferase
F8G81_RS07730	COG1522	sequence-specific DNA binding
F8G81_RS07740	COG0022	dehydrogenase e1 component
F8G81_RS07745	COG0508	dehydrogenase complex catalyzes the overall conversion of
F8G81_RS07755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F8G81_RS07765	COG1960	acyl-CoA dehydrogenase activity
F8G81_RS07800	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F8G81_RS07805	COG0750	zinc metalloprotease
F8G81_RS07825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F8G81_RS07840	COG1309	transcriptional regulator
F8G81_RS07855	COG0442	prolyl-tRNA aminoacylation
F8G81_RS07885	COG0779	Required for maturation of 30S ribosomal subunits
F8G81_RS07900	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F8G81_RS07905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F8G81_RS07910	COG0590	tRNA wobble adenosine to inosine editing
F8G81_RS07915	COG3118	belongs to the thioredoxin family
F8G81_RS07920	COG0436	Aminotransferase
F8G81_RS07925	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F8G81_RS07940	COG0196	riboflavin kinase activity
F8G81_RS07945	COG3483	tryptophan 2,3-dioxygenase activity
F8G81_RS07950	COG3844	kynureninase activity
F8G81_RS07955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F8G81_RS07960	COG1185	polyribonucleotide nucleotidyltransferase activity
F8G81_RS07965	COG0612	Peptidase, M16
F8G81_RS08005	COG0745	RESPONSE REGULATOR receiver
F8G81_RS08010	COG5002	protein histidine kinase activity
F8G81_RS08030	COG0521	Mo-molybdopterin cofactor biosynthetic process
F8G81_RS08040	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F8G81_RS08070	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F8G81_RS08075	COG1674	ftsk spoiiie
F8G81_RS08085	COG1546	Belongs to the CinA family
F8G81_RS08085	COG1058	Belongs to the CinA family
F8G81_RS08090	COG1396	sequence-specific DNA binding
F8G81_RS08105	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F8G81_RS08110	COG2137	regulation of response to DNA damage stimulus
F8G81_RS08115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F8G81_RS08120	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F8G81_RS08125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F8G81_RS08130	COG2813	Specifically methylates the guanine in position
F8G81_RS08135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F8G81_RS08145	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F8G81_RS08155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F8G81_RS08160	COG0131	Imidazoleglycerol-phosphate dehydratase
F8G81_RS08165	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F8G81_RS08175	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F8G81_RS08195	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F8G81_RS08200	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F8G81_RS08205	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F8G81_RS08210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F8G81_RS08245	COG2814	Major facilitator Superfamily
F8G81_RS08250	COG2816	NAD+ diphosphatase activity
F8G81_RS08270	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F8G81_RS08275	COG0072	phenylalanine-tRNA ligase activity
F8G81_RS08275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F8G81_RS08290	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F8G81_RS08295	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F8G81_RS08300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F8G81_RS08305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F8G81_RS08310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F8G81_RS08315	COG1438	arginine binding
F8G81_RS08320	COG0137	argininosuccinate synthase activity
F8G81_RS08325	COG0165	Argininosuccinate lyase
F8G81_RS08330	COG0259	pyridoxamine-phosphate oxidase activity
F8G81_RS08340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F8G81_RS08340	COG2169	Transcriptional regulator
F8G81_RS08350	COG2094	Belongs to the DNA glycosylase MPG family
F8G81_RS08360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F8G81_RS08390	COG0647	UMP catabolic process
F8G81_RS08405	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F8G81_RS08410	COG0497	DNA recombination
F8G81_RS08420	COG0504	CTP synthase activity
F8G81_RS08425	COG0494	nUDIX hydrolase
F8G81_RS08465	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
F8G81_RS08470	COG2079	MmgE PrpD family protein
F8G81_RS08485	COG3290	protein histidine kinase activity
F8G81_RS08490	COG1301	dicarboxylic acid transport
F8G81_RS08500	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F8G81_RS08505	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F8G81_RS08520	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F8G81_RS08530	COG1160	GTP binding
F8G81_RS08545	COG0789	Transcriptional regulator
F8G81_RS08550	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F8G81_RS08560	COG0509	glycine decarboxylation via glycine cleavage system
F8G81_RS08585	COG1192	Involved in chromosome partitioning
F8G81_RS08590	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
F8G81_RS08600	COG1940	carbohydrate kinase activity
F8G81_RS08625	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F8G81_RS08630	COG2815	serine threonine protein kinase
F8G81_RS08630	COG0515	serine threonine protein kinase
F8G81_RS08645	COG0142	geranyltranstransferase activity
F8G81_RS08655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F8G81_RS08665	COG2001	Belongs to the MraZ family
F8G81_RS08670	COG0275	rRNA processing
F8G81_RS08680	COG0768	penicillin binding
F8G81_RS08685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F8G81_RS08695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F8G81_RS08700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F8G81_RS08710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F8G81_RS08715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F8G81_RS08720	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F8G81_RS08725	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F8G81_RS08735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F8G81_RS08740	COG1799	cell septum assembly
F8G81_RS08750	COG3599	regulation of cell shape
F8G81_RS08755	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F8G81_RS08765	COG0587	DNA-directed DNA polymerase activity
F8G81_RS08780	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F8G81_RS08785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F8G81_RS08790	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS08810	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F8G81_RS08815	COG0174	glutamine synthetase
F8G81_RS08820	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F8G81_RS08840	COG2801	Transposase and inactivated derivatives
F8G81_RS08870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F8G81_RS08875	COG0321	lipoyl(octanoyl) transferase activity
F8G81_RS08885	COG1090	epimerase
F8G81_RS08890	COG4946	Tricorn protease homolog
F8G81_RS08890	COG0793	Belongs to the peptidase S41A family
F8G81_RS08905	COG0508	dehydrogenase complex catalyzes the overall conversion of
F8G81_RS08910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F8G81_RS08915	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F8G81_RS08935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F8G81_RS08960	COG1271	oxidase subunit
F8G81_RS08965	COG1294	oxidase, subunit
F8G81_RS08970	COG4988	ABC transporter
F8G81_RS08985	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F8G81_RS09005	COG1435	thymidine kinase activity
F8G81_RS09025	COG0756	dUTP diphosphatase activity
F8G81_RS09050	COG0569	domain protein
F8G81_RS09055	COG0531	amino acid
F8G81_RS09060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F8G81_RS09065	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F8G81_RS09070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F8G81_RS09075	COG3557	Belongs to the UPF0374 family
F8G81_RS09085	COG0667	Aldo Keto reductase
F8G81_RS09105	COG1122	ATPase activity
F8G81_RS09110	COG1250	3-hydroxyacyl-CoA dehydrogenase
F8G81_RS09110	COG1024	Enoyl-CoA hydratase
F8G81_RS09115	COG0183	Belongs to the thiolase family
F8G81_RS09120	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F8G81_RS09145	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F8G81_RS09160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F8G81_RS09180	COG3135	benzoate transporter
F8G81_RS09225	COG0242	peptide deformylase activity
F8G81_RS09230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F8G81_RS09240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F8G81_RS09255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F8G81_RS09255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F8G81_RS09265	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F8G81_RS09270	COG0140	phosphoribosyl-ATP diphosphatase activity
F8G81_RS09275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F8G81_RS09280	COG0107	imidazoleglycerol-phosphate synthase activity
F8G81_RS09290	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F8G81_RS09310	COG0134	indole-3-glycerol-phosphate synthase activity
F8G81_RS09315	COG0133	tryptophan synthase activity
F8G81_RS09320	COG0159	tryptophan synthase activity
F8G81_RS09325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F8G81_RS09330	COG0067	glutamate synthase
F8G81_RS09330	COG0070	glutamate synthase
F8G81_RS09330	COG0069	glutamate synthase activity
F8G81_RS09340	COG0469	pyruvate kinase activity
F8G81_RS09400	COG3118	belongs to the thioredoxin family
F8G81_RS09410	COG0604	alcohol dehydrogenase
F8G81_RS09420	COG1454	alcohol dehydrogenase
F8G81_RS09430	COG0477	Major facilitator Superfamily
F8G81_RS09445	COG1024	Enoyl-CoA hydratase
F8G81_RS09455	COG0563	adenylate kinase activity
F8G81_RS09535	COG0463	Glycosyl transferase, family 2
F8G81_RS09550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F8G81_RS09570	COG0477	Major facilitator Superfamily
F8G81_RS09585	COG2814	Major facilitator Superfamily
F8G81_RS09600	COG1802	Transcriptional regulator
F8G81_RS09605	COG1309	transcriptional regulator
F8G81_RS09610	COG1024	Enoyl-CoA hydratase
F8G81_RS09610	COG1250	3-hydroxyacyl-CoA dehydrogenase
F8G81_RS09615	COG0183	Belongs to the thiolase family
F8G81_RS09630	COG0657	acetylesterase activity
F8G81_RS09655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F8G81_RS09700	COG0251	oxidation-reduction process
F8G81_RS09740	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS09745	COG0747	negative chemotaxis
F8G81_RS09750	COG0154	amidase activity
F8G81_RS09755	COG0601	transmembrane transport
F8G81_RS09760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8G81_RS09770	COG4608	Belongs to the ABC transporter superfamily
F8G81_RS09780	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS09790	COG0473	3-isopropylmalate dehydrogenase activity
F8G81_RS09790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F8G81_RS09795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F8G81_RS09805	COG2159	amidohydrolase
F8G81_RS09810	COG3384	dioxygenase
F8G81_RS09840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8G81_RS09870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F8G81_RS09895	COG0477	Major facilitator Superfamily
F8G81_RS09900	COG0154	amidase activity
F8G81_RS09920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F8G81_RS09950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F8G81_RS09990	COG1733	regulation of RNA biosynthetic process
F8G81_RS10010	COG0583	DNA-binding transcription factor activity
F8G81_RS10020	COG0765	amino acid transport
F8G81_RS10025	COG0765	amino acid transport
F8G81_RS10035	COG0277	FAD linked oxidase domain protein
F8G81_RS10040	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS10075	COG1937	Protein conserved in bacteria
F8G81_RS10080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F8G81_RS10105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8G81_RS10115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8G81_RS10120	COG1309	transcriptional regulator
F8G81_RS10135	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
F8G81_RS10140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F8G81_RS10145	COG0531	amino acid
F8G81_RS10155	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS10160	COG0686	Belongs to the AlaDH PNT family
F8G81_RS10165	COG2873	o-acetylhomoserine
F8G81_RS10170	COG1476	TRANSCRIPTIONal
F8G81_RS10185	COG0477	Major facilitator Superfamily
F8G81_RS10200	COG1309	transcriptional regulator
F8G81_RS10205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F8G81_RS10235	COG1175	transmembrane transport
F8G81_RS10240	COG0395	ABC-type sugar transport system, permease component
F8G81_RS10245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8G81_RS10265	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8G81_RS10270	COG4948	Mandelate Racemase Muconate Lactonizing
F8G81_RS10280	COG3618	amidohydrolase
F8G81_RS10300	COG0395	ABC-type sugar transport system, permease component
F8G81_RS10305	COG1175	transmembrane transport
F8G81_RS10315	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS10320	COG1063	alcohol dehydrogenase
F8G81_RS10345	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS10365	COG0477	Major facilitator Superfamily
F8G81_RS10390	COG4608	Belongs to the ABC transporter superfamily
F8G81_RS10395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8G81_RS10400	COG2902	Dehydrogenase
F8G81_RS10410	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F8G81_RS10420	COG3654	unkown
F8G81_RS10430	COG2072	flavoprotein involved in K transport
F8G81_RS10440	COG1063	alcohol dehydrogenase
F8G81_RS10450	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F8G81_RS10455	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F8G81_RS10460	COG0563	adenylate kinase activity
F8G81_RS10465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F8G81_RS10485	COG0477	Major facilitator Superfamily
F8G81_RS10490	COG1574	metal-dependent hydrolase with the TIM-barrel fold
F8G81_RS10535	COG0583	DNA-binding transcription factor activity
F8G81_RS10540	COG2186	Transcriptional regulator
F8G81_RS10550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8G81_RS10565	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS10570	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS10595	COG2133	pyrroloquinoline quinone binding
F8G81_RS10610	COG1063	alcohol dehydrogenase
F8G81_RS10620	COG0477	Major facilitator Superfamily
F8G81_RS10630	COG2814	Major facilitator Superfamily
F8G81_RS10650	COG4989	oxidoreductase activity
F8G81_RS10660	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F8G81_RS10675	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS10710	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS10720	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS10750	COG1129	ABC transporter
F8G81_RS10765	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS10785	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS10800	COG0300	oxidoreductase activity
F8G81_RS10805	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS10825	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8G81_RS10835	COG1802	Transcriptional regulator
F8G81_RS10845	COG1063	alcohol dehydrogenase
F8G81_RS10850	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8G81_RS10865	COG2326	polyphosphate kinase activity
F8G81_RS10875	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F8G81_RS10890	COG0765	amino acid transport
F8G81_RS10895	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS10900	COG1126	abc transporter atp-binding protein
F8G81_RS10905	COG1126	abc transporter atp-binding protein
F8G81_RS10910	COG1053	succinate dehydrogenase
F8G81_RS10915	COG1234	tRNA 3'-trailer cleavage
F8G81_RS10920	COG0028	Belongs to the TPP enzyme family
F8G81_RS10935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F8G81_RS10960	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8G81_RS11005	COG1609	Transcriptional regulator
F8G81_RS11010	COG2814	Major facilitator Superfamily
F8G81_RS11025	COG1024	Enoyl-CoA hydratase
F8G81_RS11025	COG1250	3-hydroxyacyl-CoA dehydrogenase
F8G81_RS11030	COG0183	Belongs to the thiolase family
F8G81_RS11045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F8G81_RS11050	COG1414	Transcriptional regulator
F8G81_RS11060	COG4176	ABC-type proline glycine betaine transport system permease component
F8G81_RS11155	COG2271	Major facilitator Superfamily
F8G81_RS11165	COG0251	oxidation-reduction process
F8G81_RS11175	COG1129	ABC transporter
F8G81_RS11180	COG1082	Xylose isomerase domain protein TIM barrel
F8G81_RS11195	COG1172	Belongs to the binding-protein-dependent transport system permease family
F8G81_RS11205	COG0673	inositol 2-dehydrogenase activity
F8G81_RS11210	COG1940	carbohydrate kinase activity
F8G81_RS11220	COG0464	growth
F8G81_RS11225	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS11240	COG1053	succinate dehydrogenase
F8G81_RS11250	COG0028	Belongs to the TPP enzyme family
F8G81_RS11255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F8G81_RS11265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F8G81_RS11280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F8G81_RS11280	COG1116	anion transmembrane transporter activity
F8G81_RS11285	COG0028	Belongs to the TPP enzyme family
F8G81_RS11295	COG3119	arylsulfatase activity
F8G81_RS11300	COG1309	transcriptional regulator
F8G81_RS11315	COG0444	Belongs to the ABC transporter superfamily
F8G81_RS11335	COG3119	arylsulfatase activity
F8G81_RS11340	COG3119	arylsulfatase activity
F8G81_RS11360	COG0444	Belongs to the ABC transporter superfamily
F8G81_RS11375	COG3119	arylsulfatase activity
F8G81_RS11380	COG3119	arylsulfatase activity
F8G81_RS11390	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F8G81_RS11400	COG2084	Dehydrogenase
F8G81_RS11405	COG1082	Xylose isomerase domain protein TIM barrel
F8G81_RS11410	COG0149	triose-phosphate isomerase activity
F8G81_RS11415	COG0698	ribose 5-phosphate isomerase
F8G81_RS11420	COG2376	Dihydroxyacetone kinase
F8G81_RS11430	COG2186	Transcriptional regulator
F8G81_RS11440	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS11445	COG2873	o-acetylhomoserine
F8G81_RS11455	COG1121	(ABC) transporter
F8G81_RS11460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F8G81_RS11470	COG0803	Belongs to the bacterial solute-binding protein 9 family
F8G81_RS11480	COG1414	Transcriptional regulator
F8G81_RS11485	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS11500	COG1175	transmembrane transport
F8G81_RS11505	COG0395	ABC-type sugar transport system, permease component
F8G81_RS11515	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
F8G81_RS11520	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
F8G81_RS11525	COG0800	Aldolase
F8G81_RS11535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F8G81_RS11545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F8G81_RS11555	COG0444	Belongs to the ABC transporter superfamily
F8G81_RS11565	COG4608	Belongs to the ABC transporter superfamily
F8G81_RS11590	COG1335	isochorismatase
F8G81_RS11635	COG0402	S-adenosylhomocysteine deaminase activity
F8G81_RS11645	COG0154	amidase activity
F8G81_RS11655	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F8G81_RS11670	COG1960	acyl-CoA dehydrogenase activity
F8G81_RS11685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F8G81_RS11695	COG1414	Transcriptional regulator
F8G81_RS11700	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F8G81_RS11705	COG0303	'Molybdopterin
F8G81_RS11710	COG1063	alcohol dehydrogenase
F8G81_RS11720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F8G81_RS11725	COG3404	Formiminotransferase-cyclodeaminase
F8G81_RS11745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F8G81_RS11770	COG1760	l-serine dehydratase
F8G81_RS11785	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
F8G81_RS11795	COG0300	oxidoreductase activity
F8G81_RS11825	COG2814	Major facilitator Superfamily
F8G81_RS11835	COG0477	Major facilitator Superfamily
F8G81_RS11870	COG1309	transcriptional regulator
F8G81_RS11895	COG1309	transcriptional regulator
F8G81_RS11900	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS11945	COG3226	Transcriptional regulator
F8G81_RS11970	COG1063	alcohol dehydrogenase
F8G81_RS11980	COG0028	Belongs to the TPP enzyme family
F8G81_RS11985	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F8G81_RS11995	COG2159	amidohydrolase
F8G81_RS12030	COG1414	Transcriptional regulator
F8G81_RS12035	COG4604	ABC transporter, ATP-binding protein
F8G81_RS12040	COG4605	iron ion homeostasis
F8G81_RS12045	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8G81_RS12055	COG1309	transcriptional regulator
F8G81_RS12085	COG2197	response regulator
F8G81_RS12090	COG1309	transcriptional regulator
F8G81_RS12105	COG2159	amidohydrolase
F8G81_RS12115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F8G81_RS12145	COG1129	ABC transporter
F8G81_RS12150	COG1172	Belongs to the binding-protein-dependent transport system permease family
F8G81_RS12155	COG2259	Doxx family
F8G81_RS12185	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8G81_RS12200	COG2814	Major facilitator Superfamily
F8G81_RS12205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8G81_RS12215	COG4941	Belongs to the sigma-70 factor family
F8G81_RS12220	COG3795	YCII-related domain
F8G81_RS12245	COG1609	Transcriptional regulator
F8G81_RS12260	COG1175	transmembrane transport
F8G81_RS12265	COG0395	ABC-type sugar transport system, permease component
F8G81_RS12285	COG3552	Protein containing von Willebrand factor type A (VWA) domain
F8G81_RS12295	COG0714	Associated with various cellular activities
F8G81_RS12320	COG2124	cytochrome p450
F8G81_RS12325	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F8G81_RS12335	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F8G81_RS12345	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F8G81_RS12350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F8G81_RS12370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8G81_RS12375	COG2814	Major facilitator Superfamily
F8G81_RS12410	COG2186	Transcriptional regulator
F8G81_RS12420	COG0405	Gamma-glutamyltransferase
F8G81_RS12425	COG3387	PFAM Glycoside hydrolase 15-related
F8G81_RS12445	COG0601	transmembrane transport
F8G81_RS12450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8G81_RS12455	COG4172	Belongs to the ABC transporter superfamily
F8G81_RS12490	COG1643	Atp-dependent helicase
F8G81_RS12520	COG0009	L-threonylcarbamoyladenylate synthase
F8G81_RS12555	COG2050	protein possibly involved in aromatic compounds catabolism
F8G81_RS12590	COG4552	Acetyltransferase involved in intracellular survival and related
F8G81_RS12595	COG0539	negative regulation of cytoplasmic translation
F8G81_RS12605	COG1739	Uncharacterized protein family UPF0029
F8G81_RS12610	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
F8G81_RS12610	COG0237	dephospho-CoA kinase activity
F8G81_RS12615	COG0556	nucleotide-excision repair
F8G81_RS12625	COG0477	Major facilitator Superfamily
F8G81_RS12650	COG4106	trans-aconitate 2-methyltransferase activity
F8G81_RS12675	COG0546	phosphoglycolate phosphatase activity
F8G81_RS12685	COG0322	excinuclease ABC activity
F8G81_RS12690	COG1660	Displays ATPase and GTPase activities
F8G81_RS12700	COG1481	regulation of sporulation
F8G81_RS12705	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F8G81_RS12710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F8G81_RS12715	COG0126	phosphoglycerate kinase activity
F8G81_RS12720	COG0149	triose-phosphate isomerase activity
F8G81_RS12725	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F8G81_RS12735	COG0363	glucosamine-6-phosphate deaminase activity
F8G81_RS12750	COG0166	Belongs to the GPI family
F8G81_RS12755	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F8G81_RS12765	COG0109	protoheme IX farnesyltransferase activity
F8G81_RS12770	COG1612	heme a metabolic process
F8G81_RS12780	COG1131	(ABC) transporter
F8G81_RS12795	COG0719	Fe-S assembly protein
F8G81_RS12805	COG0396	ATPase activity
F8G81_RS12810	COG2151	metal-sulfur cluster biosynthetic enzyme
F8G81_RS12820	COG0318	PFAM AMP-dependent synthetase and ligase
F8G81_RS12835	COG1122	ATPase activity
F8G81_RS12840	COG1268	BioY protein
F8G81_RS12855	COG0488	(ABC) transporter
F8G81_RS12885	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS12895	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS12900	COG0560	Phosphoserine phosphatase
F8G81_RS12900	COG3830	Belongs to the UPF0237 family
F8G81_RS12905	COG1119	ATPase activity
F8G81_RS12940	COG0254	rRNA binding
F8G81_RS12955	COG2855	membrane
F8G81_RS12985	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F8G81_RS12990	COG0297	glycogen (starch) synthase activity
F8G81_RS13010	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS13030	COG0435	Glutathione S-transferase
F8G81_RS13055	COG1234	tRNA 3'-trailer cleavage
F8G81_RS13060	COG3152	Membrane
F8G81_RS13070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F8G81_RS13090	COG0667	Aldo Keto reductase
F8G81_RS13095	COG1968	undecaprenyl-diphosphatase activity
F8G81_RS13100	COG0215	cysteine-tRNA ligase activity
F8G81_RS13110	COG0546	phosphoglycolate phosphatase activity
F8G81_RS13115	COG0517	IMP dehydrogenase activity
F8G81_RS13115	COG1994	Peptidase M50
F8G81_RS13125	COG1222	aaa ATPase
F8G81_RS13130	COG4122	O-methyltransferase activity
F8G81_RS13140	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F8G81_RS13145	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F8G81_RS13150	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F8G81_RS13155	COG0545	Peptidyl-prolyl cis-trans isomerase
F8G81_RS13175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F8G81_RS13180	COG0805	protein transport
F8G81_RS13185	COG4581	dead DEAH box helicase
F8G81_RS13190	COG1574	metal-dependent hydrolase with the TIM-barrel fold
F8G81_RS13195	COG1216	Glycosyl transferase, family 2
F8G81_RS13220	COG0242	peptide deformylase activity
F8G81_RS13230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8G81_RS13240	COG3424	synthase
F8G81_RS13255	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F8G81_RS13260	COG4974	Belongs to the 'phage' integrase family
F8G81_RS13295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F8G81_RS13305	COG2755	lipolytic protein G-D-S-L family
F8G81_RS13330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F8G81_RS13335	COG1845	cytochrome c oxidase, subunit III
F8G81_RS13340	COG2010	Cytochrome c
F8G81_RS13345	COG0723	plastoquinol--plastocyanin reductase activity
F8G81_RS13350	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F8G81_RS13360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8G81_RS13370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F8G81_RS13375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F8G81_RS13395	COG0167	dihydroorotate dehydrogenase activity
F8G81_RS13410	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F8G81_RS13415	COG1381	Involved in DNA repair and RecF pathway recombination
F8G81_RS13420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F8G81_RS13425	COG3590	peptidase
F8G81_RS13430	COG1316	TRANSCRIPTIONal
F8G81_RS13435	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F8G81_RS13445	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F8G81_RS13465	COG0484	heat shock protein binding
F8G81_RS13470	COG1420	regulation of RNA biosynthetic process
F8G81_RS13490	COG0481	GTPase activity
F8G81_RS13500	COG0268	Binds directly to 16S ribosomal RNA
F8G81_RS13520	COG1819	glycosyl
F8G81_RS13540	COG1307	EDD domain protein, DegV family
F8G81_RS13545	COG0495	leucyl-tRNA aminoacylation
F8G81_RS13550	COG0574	Belongs to the PEP-utilizing enzyme family
F8G81_RS13550	COG3848	Pyruvate phosphate dikinase
F8G81_RS13555	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F8G81_RS13560	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F8G81_RS13565	COG2390	Transcriptional regulator
F8G81_RS13570	COG0656	L-ascorbic acid biosynthetic process
F8G81_RS13580	COG0438	transferase activity, transferring glycosyl groups
F8G81_RS13590	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F8G81_RS13600	COG1758	RNA polymerase activity
F8G81_RS13605	COG0194	GDP metabolic process
F8G81_RS13610	COG0194	GDP metabolic process
F8G81_RS13615	COG0284	orotidine-5'-phosphate decarboxylase activity
F8G81_RS13620	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F8G81_RS13625	COG0505	Belongs to the CarA family
F8G81_RS13635	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F8G81_RS13640	COG0540	Belongs to the ATCase OTCase family
F8G81_RS13645	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F8G81_RS13665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F8G81_RS13670	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F8G81_RS13680	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F8G81_RS13685	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F8G81_RS13690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F8G81_RS13695	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F8G81_RS13710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F8G81_RS13725	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F8G81_RS13745	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F8G81_RS13755	COG0124	histidyl-tRNA synthetase
F8G81_RS13760	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F8G81_RS13765	COG1196	nuclear chromosome segregation
F8G81_RS13775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F8G81_RS13780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F8G81_RS13785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F8G81_RS13795	COG2255	four-way junction helicase activity
F8G81_RS13800	COG0632	four-way junction helicase activity
F8G81_RS13805	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F8G81_RS13810	COG0217	transcriptional regulatory protein
F8G81_RS13815	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
F8G81_RS13820	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F8G81_RS13835	COG0339	signal peptide processing
F8G81_RS13840	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
F8G81_RS13845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F8G81_RS13855	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F8G81_RS13860	COG0587	DNA-directed DNA polymerase activity
F8G81_RS13875	COG0077	Prephenate dehydratase
F8G81_RS13875	COG1605	Chorismate mutase
F8G81_RS13885	COG2135	peptidase activity
F8G81_RS13915	COG2318	DinB family
F8G81_RS13925	COG5006	permease, DMT superfamily
F8G81_RS13945	COG2813	Specifically methylates the guanine in position
F8G81_RS13965	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS14010	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
F8G81_RS14015	COG2755	lipolytic protein G-D-S-L family
F8G81_RS14015	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F8G81_RS14045	COG4804	nuclease activity
F8G81_RS14070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F8G81_RS14075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F8G81_RS14080	COG1780	Probably involved in ribonucleotide reductase function
F8G81_RS14090	COG0583	DNA-binding transcription factor activity
F8G81_RS14100	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F8G81_RS14135	COG0714	Associated with various cellular activities
F8G81_RS14150	COG1175	transmembrane transport
F8G81_RS14165	COG2813	Specifically methylates the guanine in position
F8G81_RS14170	COG0492	ferredoxin-NADP+ reductase activity
F8G81_RS14175	COG2824	Alkylphosphonate utilization operon protein PhnA
F8G81_RS14180	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F8G81_RS14200	COG0799	negative regulation of ribosome biogenesis
F8G81_RS14210	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F8G81_RS14220	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F8G81_RS14225	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F8G81_RS14230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F8G81_RS14235	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F8G81_RS14240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F8G81_RS14245	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
F8G81_RS14245	COG0351	phosphomethylpyrimidine kinase
F8G81_RS14245	COG0352	thiamine-phosphate diphosphorylase activity
F8G81_RS14250	COG1530	ribonuclease E activity
F8G81_RS14260	COG0105	UTP biosynthetic process
F8G81_RS14270	COG0285	dihydrofolate synthase activity
F8G81_RS14275	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F8G81_RS14295	COG0525	valine-tRNA ligase activity
F8G81_RS14300	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F8G81_RS14305	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F8G81_RS14310	COG0740	serine-type endopeptidase activity
F8G81_RS14315	COG0740	serine-type endopeptidase activity
F8G81_RS14320	COG0544	peptidyl-prolyl cis-trans isomerase activity
F8G81_RS14370	COG0668	transmembrane transport
F8G81_RS14385	COG1946	Acyl-CoA thioesterase
F8G81_RS14400	COG0629	single-stranded DNA binding
F8G81_RS14415	COG2115	Belongs to the xylose isomerase family
F8G81_RS14420	COG1070	Carbohydrate kinase
F8G81_RS14435	COG0673	inositol 2-dehydrogenase activity
F8G81_RS14445	COG0657	acetylesterase activity
F8G81_RS14445	COG2755	lipolytic protein G-D-S-L family
F8G81_RS14460	COG2017	converts alpha-aldose to the beta-anomer
F8G81_RS14490	COG0242	peptide deformylase activity
F8G81_RS14515	COG3022	response to hydroperoxide
F8G81_RS14525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F8G81_RS14530	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F8G81_RS14540	COG1045	serine acetyltransferase
F8G81_RS14545	COG0300	oxidoreductase activity
F8G81_RS14550	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F8G81_RS14560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8G81_RS14565	COG0477	Major facilitator Superfamily
F8G81_RS14570	COG1414	Transcriptional regulator
F8G81_RS14600	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F8G81_RS14615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F8G81_RS14620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F8G81_RS14635	COG4974	Belongs to the 'phage' integrase family
F8G81_RS14650	COG0792	nuclease activity
F8G81_RS14660	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F8G81_RS14670	COG0681	Belongs to the peptidase S26 family
F8G81_RS14675	COG0335	large ribosomal subunit rRNA binding
F8G81_RS14680	COG0336	Belongs to the RNA methyltransferase TrmD family
F8G81_RS14685	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F8G81_RS14690	COG1837	Belongs to the UPF0109 family
F8G81_RS14695	COG0228	four-way junction DNA binding
F8G81_RS14705	COG2514	catechol 2,3-dioxygenase activity
F8G81_RS14735	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F8G81_RS14775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F8G81_RS14780	COG0571	ribonuclease III activity
F8G81_RS14785	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F8G81_RS14795	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F8G81_RS14810	COG0742	ribosomal rna small subunit methyltransferase
F8G81_RS14835	COG1181	Belongs to the D-alanine--D-alanine ligase family
F8G81_RS14840	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F8G81_RS14850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F8G81_RS14855	COG0066	3-isopropylmalate dehydratase activity
F8G81_RS14860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F8G81_RS14865	COG1414	Transcriptional regulator
F8G81_RS14900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F8G81_RS14905	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8G81_RS14910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8G81_RS14920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F8G81_RS14925	COG0473	3-isopropylmalate dehydrogenase activity
F8G81_RS14945	COG0577	efflux transmembrane transporter activity
F8G81_RS14945	COG1136	(ABC) transporter
F8G81_RS14955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8G81_RS14960	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F8G81_RS14965	COG0440	acetolactate synthase activity
F8G81_RS14975	COG0129	dihydroxy-acid dehydratase activity
F8G81_RS14980	COG0583	DNA-binding transcription factor activity
F8G81_RS15005	COG3655	Transcriptional regulator
F8G81_RS15015	COG1045	serine acetyltransferase
F8G81_RS15040	COG0747	negative chemotaxis
F8G81_RS15045	COG0579	oxidoreductase
F8G81_RS15050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F8G81_RS15060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8G81_RS15070	COG1305	Transglutaminase-like
F8G81_RS15100	COG1104	cysteine desulfurase activity
F8G81_RS15110	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F8G81_RS15115	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F8G81_RS15125	COG1113	amino acid transport
F8G81_RS15160	COG1414	Transcriptional regulator
F8G81_RS15170	COG0419	ATPase involved in DNA repair
F8G81_RS15175	COG0420	3'-5' exonuclease activity
F8G81_RS15200	COG0586	Pfam SNARE associated Golgi protein
F8G81_RS15205	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F8G81_RS15210	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F8G81_RS15215	COG1234	tRNA 3'-trailer cleavage
F8G81_RS15220	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F8G81_RS15230	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F8G81_RS15240	COG1335	isochorismatase
F8G81_RS15255	COG0363	glucosamine-6-phosphate deaminase activity
F8G81_RS15270	COG1902	pentaerythritol trinitrate reductase activity
F8G81_RS15285	COG0628	permease
F8G81_RS15300	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
F8G81_RS15310	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
F8G81_RS15315	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F8G81_RS15325	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F8G81_RS15330	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F8G81_RS15335	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F8G81_RS15340	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F8G81_RS15345	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F8G81_RS15350	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F8G81_RS15355	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F8G81_RS15360	COG0356	it plays a direct role in the translocation of protons across the membrane
F8G81_RS15375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F8G81_RS15380	COG1216	Glycosyl transferase, family 2
F8G81_RS15395	COG2890	protein-(glutamine-N5) methyltransferase activity
F8G81_RS15400	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F8G81_RS15410	COG0083	homoserine kinase activity
F8G81_RS15415	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F8G81_RS15420	COG0460	homoserine dehydrogenase
F8G81_RS15425	COG0019	diaminopimelate decarboxylase activity
F8G81_RS15430	COG0018	arginyl-trna synthetase
F8G81_RS15480	COG1643	Atp-dependent helicase
F8G81_RS15485	COG0537	adenosine 5'-monophosphoramidase activity
F8G81_RS15490	COG1064	alcohol dehydrogenase
F8G81_RS15505	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F8G81_RS15520	COG1121	(ABC) transporter
F8G81_RS15540	COG0567	Dehydrogenase, E1 component
F8G81_RS15540	COG0508	dehydrogenase complex catalyzes the overall conversion of
F8G81_RS15565	COG1595	DNA-templated transcription, initiation
F8G81_RS15575	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F8G81_RS15585	COG0483	inositol monophosphate 1-phosphatase activity
F8G81_RS15590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F8G81_RS15605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F8G81_RS15610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F8G81_RS15630	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F8G81_RS15640	COG2177	Part of the ABC transporter FtsEX involved in
F8G81_RS15645	COG2884	Cell division ATP-binding protein ftsE
F8G81_RS15650	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F8G81_RS15735	COG1088	dTDP-glucose 4,6-dehydratase activity
F8G81_RS15740	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
F8G81_RS15760	COG0463	Glycosyl transferase, family 2
F8G81_RS15775	COG1215	transferase activity, transferring glycosyl groups
F8G81_RS15795	COG1216	Glycosyl transferase, family 2
F8G81_RS15810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F8G81_RS15840	COG2902	Dehydrogenase
F8G81_RS15875	COG0653	protein targeting
F8G81_RS15880	COG3214	Protein conserved in bacteria
F8G81_RS15885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F8G81_RS15895	COG5401	PFAM Sporulation and spore germination
F8G81_RS15900	COG5002	protein histidine kinase activity
F8G81_RS15925	COG0714	Associated with various cellular activities
F8G81_RS15950	COG0482	sulfurtransferase activity
F8G81_RS15980	COG0477	Major facilitator Superfamily
F8G81_RS15985	COG0484	heat shock protein binding
F8G81_RS15990	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F8G81_RS15995	COG1595	DNA-templated transcription, initiation
F8G81_RS16010	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F8G81_RS16015	COG2086	electron transfer activity
F8G81_RS16020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F8G81_RS16030	COG1842	Phage shock protein A
F8G81_RS16050	COG1615	UPF0182 protein
F8G81_RS16055	COG3480	Lon protease (S16) C-terminal proteolytic domain
F8G81_RS16080	COG2816	NAD+ diphosphatase activity
F8G81_RS16110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8G81_RS16115	COG0765	amino acid transport
F8G81_RS16120	COG1126	abc transporter atp-binding protein
F8G81_RS16125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F8G81_RS16130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8G81_RS16145	COG0181	hydroxymethylbilane synthase activity
F8G81_RS16150	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F8G81_RS16155	COG3253	May function as heme-dependent peroxidase
F8G81_RS16170	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F8G81_RS16175	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F8G81_RS16200	COG2154	pterin-4-alpha-carbinolamine dehydratase
F8G81_RS16205	COG2022	thiamine diphosphate biosynthetic process
F8G81_RS16215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8G81_RS16215	COG2022	thiamine diphosphate biosynthetic process
F8G81_RS16220	COG0352	thiamine-phosphate diphosphorylase activity
F8G81_RS16230	COG0513	Belongs to the DEAD box helicase family
F8G81_RS16235	COG2189	Belongs to the N(4) N(6)-methyltransferase family
F8G81_RS16245	COG0006	proline dipeptidase activity
F8G81_RS16255	COG2239	Acts as a magnesium transporter
F8G81_RS16270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F8G81_RS16280	COG1595	DNA-templated transcription, initiation
F8G81_RS16305	COG1611	Belongs to the LOG family
F8G81_RS16310	COG1126	abc transporter atp-binding protein
F8G81_RS16315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8G81_RS16320	COG0765	amino acid transport
F8G81_RS16325	COG0765	amino acid transport
F8G81_RS16330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F8G81_RS16335	COG2171	N-acyltransferase activity
F8G81_RS16350	COG3226	Transcriptional regulator
F8G81_RS16355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F8G81_RS16385	COG1217	gtp-binding protein TYPA
F8G81_RS16400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8G81_RS16410	COG0747	negative chemotaxis
F8G81_RS16425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8G81_RS16430	COG1116	anion transmembrane transporter activity
F8G81_RS16435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8G81_RS16440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8G81_RS16445	COG0667	Aldo Keto reductase
F8G81_RS16550	COG0012	GTP binding
F8G81_RS16560	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F8G81_RS16570	COG1570	exodeoxyribonuclease VII activity
F8G81_RS16575	COG1722	exodeoxyribonuclease VII activity
F8G81_RS16580	COG2326	polyphosphate kinase activity
F8G81_RS16600	COG2971	BadF BadG BcrA BcrD
F8G81_RS16605	COG0583	DNA-binding transcription factor activity
F8G81_RS16610	COG2814	Major facilitator Superfamily
F8G81_RS16635	COG0598	Magnesium transport protein CorA
F8G81_RS16645	COG0436	Aminotransferase
F8G81_RS16670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F8G81_RS16695	COG0519	Catalyzes the synthesis of GMP from XMP
F8G81_RS16695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F8G81_RS16715	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F8G81_RS16720	COG0516	GMP reductase activity
F8G81_RS16745	COG1132	(ABC) transporter
F8G81_RS16755	COG2755	lipolytic protein G-D-S-L family
F8G81_RS16755	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F8G81_RS16760	COG2072	flavoprotein involved in K transport
F8G81_RS16765	COG2197	response regulator
F8G81_RS16770	COG1793	dna ligase
F8G81_RS16780	COG0459	protein refolding
F8G81_RS16785	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F8G81_RS16800	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F8G81_RS16810	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F8G81_RS16815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F8G81_RS16820	COG0456	acetyltransferase
F8G81_RS16830	COG0802	atpase or kinase
F8G81_RS16835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F8G81_RS16845	COG1486	melibiose metabolic process
F8G81_RS16855	COG0438	transferase activity, transferring glycosyl groups
F8G81_RS16860	COG2759	Belongs to the formate--tetrahydrofolate ligase family
F8G81_RS16875	COG0667	Aldo Keto reductase
F8G81_RS16895	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F8G81_RS16895	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F8G81_RS16900	COG0736	holo-[acyl-carrier-protein] synthase activity
F8G81_RS16910	COG1072	(Pantothenic acid kinase))
F8G81_RS16915	COG1876	peptidase activity
F8G81_RS16920	COG1970	mechanosensitive ion channel activity
F8G81_RS16925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F8G81_RS16930	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F8G81_RS16935	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F8G81_RS16940	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F8G81_RS16945	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
F8G81_RS16975	COG0455	bacterial-type flagellum organization
F8G81_RS17015	COG1192	Involved in chromosome partitioning
F8G81_RS17050	COG0101	tRNA pseudouridine synthase activity
F8G81_RS17055	COG0203	ribosomal protein L17
F8G81_RS17060	COG0202	RNA polymerase activity
F8G81_RS17065	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F8G81_RS17070	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F8G81_RS17075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F8G81_RS17080	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F8G81_RS17085	COG3191	aminopeptidase activity
F8G81_RS17100	COG0318	PFAM AMP-dependent synthetase and ligase
F8G81_RS17110	COG0463	Glycosyl transferase, family 2
F8G81_RS17120	COG0563	adenylate kinase activity
F8G81_RS17130	COG0200	Binds to the 23S rRNA
F8G81_RS17135	COG1841	ribosomal large subunit assembly
F8G81_RS17140	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F8G81_RS17150	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F8G81_RS17155	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F8G81_RS17160	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F8G81_RS17165	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F8G81_RS17170	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F8G81_RS17175	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F8G81_RS17180	COG0255	Belongs to the universal ribosomal protein uL29 family
F8G81_RS17185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F8G81_RS17190	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F8G81_RS17195	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F8G81_RS17200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F8G81_RS17205	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F8G81_RS17210	COG0089	rRNA binding
F8G81_RS17215	COG0088	Forms part of the polypeptide exit tunnel
F8G81_RS17220	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F8G81_RS17225	COG0051	transcription antitermination factor activity, RNA binding
F8G81_RS17245	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F8G81_RS17250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F8G81_RS17255	COG0049	tRNA binding
F8G81_RS17260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F8G81_RS17265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F8G81_RS17270	COG0085	RNA polymerase activity
F8G81_RS17275	COG0183	Belongs to the thiolase family
F8G81_RS17280	COG0442	prolyl-tRNA aminoacylation
F8G81_RS17285	COG0222	ribosome binding
F8G81_RS17290	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F8G81_RS17305	COG0081	regulation of translation
F8G81_RS17310	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F8G81_RS17320	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F8G81_RS17330	COG0436	Aminotransferase
F8G81_RS17340	COG2801	Transposase and inactivated derivatives
F8G81_RS17345	COG2197	response regulator
F8G81_RS17385	COG2197	response regulator
F8G81_RS17405	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F8G81_RS17410	COG3485	protocatechuate 3,4-dioxygenase
F8G81_RS17420	COG0745	RESPONSE REGULATOR receiver
F8G81_RS17425	COG0456	acetyltransferase
F8G81_RS17430	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F8G81_RS17450	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F8G81_RS17455	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F8G81_RS17490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F8G81_RS17510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F8G81_RS17520	COG2030	dehydratase
F8G81_RS17530	COG0659	secondary active sulfate transmembrane transporter activity
F8G81_RS17550	COG4989	oxidoreductase activity
F8G81_RS17555	COG0366	Alpha amylase catalytic
F8G81_RS17560	COG1940	carbohydrate kinase activity
F8G81_RS17565	COG0702	epimerase
F8G81_RS17575	COG0706	membrane insertase activity
F8G81_RS17630	COG0754	glutathionylspermidine amidase activity
F8G81_RS17645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F8G81_RS17650	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS17655	COG5650	phosphatidylinositol metabolic process
F8G81_RS17660	COG1051	belongs to the nudix hydrolase family
F8G81_RS17695	COG2197	response regulator
F8G81_RS17710	COG2132	Multicopper oxidase
F8G81_RS17715	COG0318	PFAM AMP-dependent synthetase and ligase
F8G81_RS17725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F8G81_RS17730	COG1131	(ABC) transporter
F8G81_RS17755	COG1388	LysM domain
F8G81_RS17755	COG3942	CHAP domain
F8G81_RS17775	COG1666	GTP binding
F8G81_RS17780	COG0501	Belongs to the peptidase M48B family
F8G81_RS17805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F8G81_RS17820	COG0531	amino acid
F8G81_RS17900	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS17920	COG2186	Transcriptional regulator
F8G81_RS17955	COG1648	precorrin-2 dehydrogenase activity
F8G81_RS17955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F8G81_RS17985	COG1116	anion transmembrane transporter activity
F8G81_RS17995	COG1690	Belongs to the RtcB family
F8G81_RS18020	COG0175	sulfate reduction
F8G81_RS18025	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F8G81_RS18035	COG2860	membrane
F8G81_RS18050	COG0142	geranyltranstransferase activity
F8G81_RS18060	COG2226	methyltransferase
F8G81_RS18065	COG1169	isochorismate synthase
F8G81_RS18070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8G81_RS18075	COG0765	amino acid transport
F8G81_RS18080	COG1126	abc transporter atp-binding protein
F8G81_RS18090	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
F8G81_RS18100	COG4948	Mandelate Racemase Muconate Lactonizing
F8G81_RS18185	COG0702	epimerase
F8G81_RS18255	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F8G81_RS18255	COG2755	lipolytic protein G-D-S-L family
F8G81_RS18260	COG0508	dehydrogenase complex catalyzes the overall conversion of
F8G81_RS18265	COG0022	dehydrogenase e1 component
F8G81_RS18285	COG0489	protein tyrosine kinase activity
F8G81_RS18325	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F8G81_RS18345	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F8G81_RS18350	COG1024	Enoyl-CoA hydratase
F8G81_RS18355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F8G81_RS18360	COG2151	metal-sulfur cluster biosynthetic enzyme
F8G81_RS18365	COG3396	Phenylacetate-CoA oxygenase
F8G81_RS18370	COG3460	Phenylacetate-CoA oxygenase
F8G81_RS18375	COG3396	Phenylacetate-CoA oxygenase
F8G81_RS18410	COG0640	Transcriptional regulator
F8G81_RS18445	COG1280	lysine exporter protein (LysE YggA)
F8G81_RS18475	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
F8G81_RS18480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8G81_RS18485	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8G81_RS18490	COG1120	ATPase activity
F8G81_RS18495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F8G81_RS18505	COG1316	TRANSCRIPTIONal
F8G81_RS18510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F8G81_RS18520	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F8G81_RS18560	COG0667	Aldo Keto reductase
F8G81_RS18585	COG4213	ABC transporter substrate-binding protein
F8G81_RS18590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F8G81_RS18595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F8G81_RS18605	COG0280	phosphate acetyltransferase
F8G81_RS18605	COG0857	belongs to the CobB CobQ family
F8G81_RS18615	COG2050	protein possibly involved in aromatic compounds catabolism
F8G81_RS18630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F8G81_RS18645	COG3546	catalase activity
F8G81_RS18650	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS18650	COG2030	dehydratase
F8G81_RS18655	COG2050	protein possibly involved in aromatic compounds catabolism
F8G81_RS18680	COG1250	3-hydroxyacyl-CoA dehydrogenase
F8G81_RS18685	COG1024	Enoyl-CoA hydratase
F8G81_RS18690	COG0183	Belongs to the thiolase family
F8G81_RS18705	COG3237	CsbD-like
F8G81_RS18730	COG2146	nitrite reductase [NAD(P)H] activity
F8G81_RS18735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F8G81_RS18745	COG0488	(ABC) transporter
F8G81_RS18750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F8G81_RS18755	COG1121	(ABC) transporter
F8G81_RS18765	COG1266	CAAX protease self-immunity
F8G81_RS18775	COG0395	ABC-type sugar transport system, permease component
F8G81_RS18780	COG1175	transmembrane transport
F8G81_RS18795	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
F8G81_RS18850	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F8G81_RS18860	COG0785	Cytochrome C biogenesis protein
F8G81_RS18865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F8G81_RS18870	COG0406	alpha-ribazole phosphatase activity
F8G81_RS18875	COG2353	YceI-like domain
F8G81_RS18890	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F8G81_RS18915	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F8G81_RS18920	COG3458	cephalosporin-C deacetylase activity
F8G81_RS18925	COG1070	Carbohydrate kinase
F8G81_RS18930	COG3347	Dehydrogenase
F8G81_RS18930	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS18940	COG3254	rhamnose metabolic process
F8G81_RS18945	COG1609	Transcriptional regulator
F8G81_RS18965	COG2755	lipolytic protein G-D-S-L family
F8G81_RS18970	COG0673	inositol 2-dehydrogenase activity
F8G81_RS18990	COG0395	ABC-type sugar transport system, permease component
F8G81_RS18995	COG1175	transmembrane transport
F8G81_RS19025	COG1653	transport
F8G81_RS19030	COG0395	ABC-type sugar transport system, permease component
F8G81_RS19035	COG1175	transmembrane transport
F8G81_RS19045	COG0673	inositol 2-dehydrogenase activity
F8G81_RS19055	COG0659	secondary active sulfate transmembrane transporter activity
F8G81_RS19065	COG4948	Mandelate Racemase Muconate Lactonizing
F8G81_RS19070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F8G81_RS19080	COG0673	inositol 2-dehydrogenase activity
F8G81_RS19085	COG1609	Transcriptional regulator
F8G81_RS19090	COG2186	Transcriptional regulator
F8G81_RS19105	COG0640	Transcriptional regulator
F8G81_RS19110	COG0123	including yeast histone deacetylase and acetoin utilization protein
F8G81_RS19115	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F8G81_RS19120	COG0569	domain protein
F8G81_RS19125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F8G81_RS19130	COG0248	Ppx GppA phosphatase
F8G81_RS19140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F8G81_RS19140	COG1754	DNA topoisomerase type I activity
F8G81_RS19150	COG2890	protein-(glutamine-N5) methyltransferase activity
F8G81_RS19155	COG0789	Transcriptional regulator
F8G81_RS19175	COG1054	Belongs to the UPF0176 family
F8G81_RS19185	COG1111	helicase
F8G81_RS19185	COG1205	dead DEAH box helicase
F8G81_RS19225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F8G81_RS19225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F8G81_RS19240	COG0494	nUDIX hydrolase
F8G81_RS19255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F8G81_RS19260	COG1349	DNA-binding transcription factor activity
F8G81_RS19265	COG1609	Transcriptional regulator
F8G81_RS19275	COG4209	transmembrane transport
F8G81_RS19280	COG0395	ABC-type sugar transport system, permease component
F8G81_RS19295	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F8G81_RS19320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F8G81_RS19340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F8G81_RS19345	COG1408	metallophosphoesterase
F8G81_RS19350	COG1132	(ABC) transporter
F8G81_RS19355	COG1132	(ABC) transporter
F8G81_RS19375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F8G81_RS19380	COG0151	Belongs to the GarS family
F8G81_RS19400	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS19415	COG0667	Aldo Keto reductase
F8G81_RS19420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F8G81_RS19430	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F8G81_RS19430	COG3608	succinylglutamate desuccinylase aspartoacylase
F8G81_RS19435	COG2252	PERMEase
F8G81_RS19440	COG0590	tRNA wobble adenosine to inosine editing
F8G81_RS19450	COG1793	dna ligase
F8G81_RS19450	COG3285	dna ligase
F8G81_RS19465	COG2233	PERMEase
F8G81_RS19475	COG1414	Transcriptional regulator
F8G81_RS19485	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F8G81_RS19495	COG3257	ureidoglycine aminohydrolase activity
F8G81_RS19505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F8G81_RS19515	COG3387	PFAM Glycoside hydrolase 15-related
F8G81_RS19540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F8G81_RS19550	COG0484	heat shock protein binding
F8G81_RS19555	COG0071	Belongs to the small heat shock protein (HSP20) family
F8G81_RS19560	COG0789	Transcriptional regulator
F8G81_RS19575	COG4335	DNA alkylation repair
F8G81_RS19580	COG4213	ABC transporter substrate-binding protein
F8G81_RS19585	COG1129	ABC transporter
F8G81_RS19590	COG4214	carbohydrate transport
F8G81_RS19615	COG0251	oxidation-reduction process
F8G81_RS19625	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS19630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8G81_RS19635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8G81_RS19645	COG2188	Transcriptional regulator
F8G81_RS19655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8G81_RS19660	COG0563	adenylate kinase activity
F8G81_RS19675	COG0346	lactoylglutathione lyase activity
F8G81_RS19680	COG2610	gluconate transmembrane transporter activity
F8G81_RS19685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8G81_RS19695	COG3265	gluconokinase activity
F8G81_RS19700	COG1063	alcohol dehydrogenase
F8G81_RS19705	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS19745	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8G81_RS19755	COG2267	carboxylic ester hydrolase activity
F8G81_RS19775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8G81_RS19780	COG0579	oxidoreductase
F8G81_RS19785	COG3338	carbonate dehydratase activity
F8G81_RS19820	COG0583	DNA-binding transcription factor activity
F8G81_RS19840	COG1597	lipid kinase activity
F8G81_RS19850	COG0583	DNA-binding transcription factor activity
F8G81_RS19855	COG2828	Protein conserved in bacteria
F8G81_RS19870	COG0589	response to stress
F8G81_RS19885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8G81_RS19890	COG0765	amino acid transport
F8G81_RS19895	COG1126	abc transporter atp-binding protein
F8G81_RS19915	COG2186	Transcriptional regulator
F8G81_RS19925	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS19930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8G81_RS19960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F8G81_RS19965	COG0596	Alpha beta hydrolase
F8G81_RS19980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F8G81_RS20005	COG0024	Methionine aminopeptidase
F8G81_RS20020	COG2186	Transcriptional regulator
F8G81_RS20025	COG1027	Aspartate ammonia-lyase
F8G81_RS20045	COG1175	transmembrane transport
F8G81_RS20050	COG0395	ABC-type sugar transport system, permease component
F8G81_RS20055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8G81_RS20060	COG3507	Belongs to the glycosyl hydrolase 43 family
F8G81_RS20065	COG1609	Transcriptional regulator
F8G81_RS20070	COG3345	alpha-galactosidase
F8G81_RS20085	COG0563	adenylate kinase activity
F8G81_RS20115	COG1621	beta-fructofuranosidase activity
F8G81_RS20125	COG0395	ABC-type sugar transport system, permease component
F8G81_RS20130	COG4209	transmembrane transport
F8G81_RS20135	COG1609	Transcriptional regulator
F8G81_RS20145	COG1621	beta-fructofuranosidase activity
F8G81_RS20155	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
F8G81_RS20170	COG2202	Pas domain
F8G81_RS20170	COG2205	protein histidine kinase activity
F8G81_RS20225	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS20245	COG1126	abc transporter atp-binding protein
F8G81_RS20250	COG0765	amino acid transport
F8G81_RS20255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8G81_RS20270	COG2186	Transcriptional regulator
F8G81_RS20285	COG2326	polyphosphate kinase activity
F8G81_RS20335	COG0745	RESPONSE REGULATOR receiver
F8G81_RS20390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F8G81_RS20395	COG2186	Transcriptional regulator
F8G81_RS20400	COG0531	amino acid
F8G81_RS20410	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F8G81_RS20415	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS20420	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS20440	COG0454	-acetyltransferase
F8G81_RS20450	COG0583	DNA-binding transcription factor activity
F8G81_RS20465	COG2197	response regulator
F8G81_RS20485	COG3845	ABC transporter
F8G81_RS20490	COG1960	acyl-CoA dehydrogenase activity
F8G81_RS20495	COG0183	Belongs to the thiolase family
F8G81_RS20500	COG0318	PFAM AMP-dependent synthetase and ligase
F8G81_RS20505	COG1024	Enoyl-CoA hydratase
F8G81_RS20505	COG1250	3-hydroxyacyl-CoA dehydrogenase
F8G81_RS20520	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F8G81_RS20525	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F8G81_RS20530	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F8G81_RS20555	COG1607	acyl-coa hydrolase
F8G81_RS20560	COG2072	flavoprotein involved in K transport
F8G81_RS20565	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS20575	COG1024	Enoyl-CoA hydratase
F8G81_RS20580	COG0318	PFAM AMP-dependent synthetase and ligase
F8G81_RS20590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F8G81_RS20605	COG0657	acetylesterase activity
F8G81_RS20615	COG1410	methionine synthase
F8G81_RS20615	COG0646	methionine synthase
F8G81_RS20650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F8G81_RS20660	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F8G81_RS20665	COG0509	glycine decarboxylation via glycine cleavage system
F8G81_RS20670	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F8G81_RS20675	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F8G81_RS20675	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F8G81_RS20690	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
F8G81_RS20710	COG3268	Saccharopine dehydrogenase
F8G81_RS20715	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F8G81_RS20720	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F8G81_RS20725	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
F8G81_RS20735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F8G81_RS20740	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
F8G81_RS20755	COG1228	amidohydrolase
F8G81_RS20775	COG2814	Major facilitator Superfamily
F8G81_RS20785	COG0604	alcohol dehydrogenase
F8G81_RS20805	COG1490	D-aminoacyl-tRNA deacylase activity
F8G81_RS20815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8G81_RS20845	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS20850	COG0475	glutathione-regulated potassium exporter activity
F8G81_RS20965	COG3226	Transcriptional regulator
F8G81_RS20980	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F8G81_RS21000	COG4762	Protein conserved in bacteria
F8G81_RS21035	COG1609	Transcriptional regulator
F8G81_RS21045	COG1175	transmembrane transport
F8G81_RS21050	COG0395	ABC-type sugar transport system, permease component
F8G81_RS21065	COG0673	inositol 2-dehydrogenase activity
F8G81_RS21070	COG1609	Transcriptional regulator
F8G81_RS21075	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS21105	COG0745	RESPONSE REGULATOR receiver
F8G81_RS21130	COG0395	ABC-type sugar transport system, permease component
F8G81_RS21150	COG4585	Histidine kinase
F8G81_RS21185	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F8G81_RS21195	COG0673	inositol 2-dehydrogenase activity
F8G81_RS21205	COG0395	ABC-type sugar transport system, permease component
F8G81_RS21215	COG2182	Extracellular solute-binding protein
F8G81_RS21220	COG1609	Transcriptional regulator
F8G81_RS21225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F8G81_RS21240	COG1301	dicarboxylic acid transport
F8G81_RS21265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F8G81_RS21270	COG3622	Belongs to the hyi family
F8G81_RS21275	COG2084	Dehydrogenase
F8G81_RS21280	COG3960	tartronate-semialdehyde synthase activity
F8G81_RS21285	COG1929	Belongs to the glycerate kinase type-1 family
F8G81_RS21290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F8G81_RS21330	COG0745	RESPONSE REGULATOR receiver
F8G81_RS21340	COG1366	Belongs to the anti-sigma-factor antagonist family
F8G81_RS21355	COG2351	hydroxyisourate hydrolase activity
F8G81_RS21370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F8G81_RS21425	COG3585	molybdate ion transport
F8G81_RS21445	COG3304	Inner membrane component domain
F8G81_RS21450	COG0135	phosphoribosylanthranilate isomerase activity
F8G81_RS21460	COG1528	Iron-storage protein
F8G81_RS21470	COG2076	Multidrug Resistance protein
F8G81_RS21475	COG0563	adenylate kinase activity
F8G81_RS21480	COG0667	Aldo Keto reductase
F8G81_RS21490	COG1131	(ABC) transporter
F8G81_RS21505	COG0500	methyltransferase
F8G81_RS21525	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F8G81_RS21595	COG2217	Heavy metal translocating P-type atpase
F8G81_RS21600	COG2217	Heavy metal translocating P-type atpase
F8G81_RS21615	COG1131	(ABC) transporter
F8G81_RS21630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F8G81_RS21675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F8G81_RS21680	COG1802	Transcriptional regulator
F8G81_RS21695	COG3971	2-oxopent-4-enoate hydratase activity
F8G81_RS21710	COG0789	Transcriptional regulator
F8G81_RS21715	COG0484	heat shock protein binding
F8G81_RS21720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F8G81_RS21725	COG0443	Heat shock 70 kDa protein
F8G81_RS21735	COG0395	ABC-type sugar transport system, permease component
F8G81_RS21740	COG1175	transmembrane transport
F8G81_RS21760	COG2409	Drug exporters of the RND superfamily
F8G81_RS21840	COG1280	lysine exporter protein (LysE YggA)
F8G81_RS21845	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F8G81_RS21855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F8G81_RS21865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F8G81_RS21910	COG0183	Belongs to the thiolase family
F8G81_RS21960	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F8G81_RS21965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F8G81_RS21980	COG1122	ATPase activity
F8G81_RS21985	COG4721	ABC-type cobalt transport system, permease component
F8G81_RS21990	COG4702	Belongs to the UPF0303 family
F8G81_RS22000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8G81_RS22020	COG3655	Transcriptional regulator
F8G81_RS22035	COG1320	monovalent cation:proton antiporter activity
F8G81_RS22040	COG2212	antiporter activity
F8G81_RS22045	COG1863	multisubunit Na H antiporter MnhE subunit
F8G81_RS22050	COG0651	ATP synthesis coupled electron transport
F8G81_RS22055	COG1006	Multisubunit Na H antiporter MnhC subunit
F8G81_RS22060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F8G81_RS22060	COG2111	Na H antiporter
F8G81_RS22070	COG2985	domain, Protein
F8G81_RS22070	COG0569	domain protein
F8G81_RS22075	COG0475	glutathione-regulated potassium exporter activity
F8G81_RS22085	COG0717	Belongs to the dCTP deaminase family
F8G81_RS22120	COG2814	Major facilitator Superfamily
F8G81_RS22125	COG0583	DNA-binding transcription factor activity
F8G81_RS22135	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS22140	COG0531	amino acid
F8G81_RS22150	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F8G81_RS22155	COG0679	Auxin Efflux Carrier
F8G81_RS22165	COG2814	Major facilitator Superfamily
F8G81_RS22170	COG3387	PFAM Glycoside hydrolase 15-related
F8G81_RS22175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8G81_RS22185	COG0433	COG0433 Predicted ATPase
F8G81_RS22200	COG3336	cytochrome c oxidase
F8G81_RS22205	COG0776	regulation of translation
F8G81_RS22230	COG1609	Transcriptional regulator
F8G81_RS22250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F8G81_RS22255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F8G81_RS22260	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F8G81_RS22285	COG2801	Transposase and inactivated derivatives
F8G81_RS22300	COG1120	ATPase activity
F8G81_RS22305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8G81_RS22310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8G81_RS22355	COG3012	SEC-C Motif Domain Protein
F8G81_RS22365	COG0667	Aldo Keto reductase
F8G81_RS22370	COG0667	Aldo Keto reductase
F8G81_RS22415	COG3387	PFAM Glycoside hydrolase 15-related
F8G81_RS22420	COG2186	Transcriptional regulator
F8G81_RS22430	COG1027	Aspartate ammonia-lyase
F8G81_RS22440	COG2186	Transcriptional regulator
F8G81_RS22450	COG1172	Belongs to the binding-protein-dependent transport system permease family
F8G81_RS22475	COG4948	Mandelate Racemase Muconate Lactonizing
F8G81_RS22480	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8G81_RS22485	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS22495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F8G81_RS22525	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS22535	COG1028	Short-chain dehydrogenase reductase Sdr
F8G81_RS22555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F8G81_RS22580	COG1280	lysine exporter protein (LysE YggA)
F8G81_RS22595	COG0281	malic enzyme
F8G81_RS22600	COG1309	transcriptional regulator
F8G81_RS22625	COG0477	Major facilitator Superfamily
F8G81_RS22630	COG0477	Major facilitator Superfamily
F8G81_RS22640	COG0246	Mannitol dehydrogenase
F8G81_RS22655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F8G81_RS22680	COG0686	Belongs to the AlaDH PNT family
F8G81_RS22685	COG0673	inositol 2-dehydrogenase activity
F8G81_RS22715	COG0431	NADPH-dependent FMN reductase
F8G81_RS22730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F8G81_RS22745	COG0508	dehydrogenase complex catalyzes the overall conversion of
F8G81_RS22750	COG0022	dehydrogenase e1 component
F8G81_RS22760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F8G81_RS22765	COG1950	PFAM Membrane protein of
F8G81_RS22780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F8G81_RS22785	COG0406	alpha-ribazole phosphatase activity
F8G81_RS22795	COG1840	ABC-type Fe3 transport system, periplasmic component
F8G81_RS22800	COG3842	ATPase activity
F8G81_RS22805	COG1178	ABC-type Fe3 transport system permease component
F8G81_RS22825	COG1597	lipid kinase activity
F8G81_RS22850	COG1414	Transcriptional regulator
F8G81_RS22855	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F8G81_RS22865	COG0183	Belongs to the thiolase family
F8G81_RS22870	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F8G81_RS22880	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F8G81_RS22885	COG3485	protocatechuate 3,4-dioxygenase
F8G81_RS22890	COG3485	protocatechuate 3,4-dioxygenase
F8G81_RS22895	COG3185	4-Hydroxyphenylpyruvate dioxygenase
F8G81_RS22895	COG1082	Xylose isomerase domain protein TIM barrel
F8G81_RS22900	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F8G81_RS22905	COG1414	Transcriptional regulator
F8G81_RS22920	COG1793	dna ligase
F8G81_RS22935	COG0366	Alpha amylase catalytic
F8G81_RS22955	COG1940	carbohydrate kinase activity
F8G81_RS22975	COG0515	serine threonine protein kinase
F8G81_RS22975	COG2815	serine threonine protein kinase
F8G81_RS22990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F8G81_RS22995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F8G81_RS23000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F8G81_RS23005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F8G81_RS23020	COG1012	belongs to the aldehyde dehydrogenase family
F8G81_RS23025	COG2807	transmembrane transport
F8G81_RS23030	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F8G81_RS23040	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F8G81_RS23055	COG4177	L-phenylalanine transmembrane transporter activity
F8G81_RS23075	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F8G81_RS23080	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F8G81_RS23110	COG1937	Protein conserved in bacteria
F8G81_RS23135	COG0697	spore germination
F8G81_RS23160	COG2259	Doxx family
F8G81_RS23170	COG3401	FG-GAP repeat protein
F8G81_RS23180	COG0305	Participates in initiation and elongation during chromosome replication
F8G81_RS23210	COG0359	binds to the 23S rRNA
F8G81_RS23215	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F8G81_RS23225	COG0360	Binds together with S18 to 16S ribosomal RNA
F8G81_RS23235	COG1113	amino acid transport
F8G81_RS23245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F8G81_RS23260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F8G81_RS23270	COG1216	Glycosyl transferase, family 2
F8G81_RS23270	COG0463	Glycosyl transferase, family 2
F8G81_RS23285	COG1215	transferase activity, transferring glycosyl groups
F8G81_RS23335	COG1362	aminopeptidase activity
F8G81_RS23345	COG2197	response regulator
F8G81_RS23350	COG4585	Histidine kinase
F8G81_RS23360	COG1131	(ABC) transporter
F8G81_RS23370	COG0738	Major facilitator superfamily
F8G81_RS23385	COG0488	(ABC) transporter
F8G81_RS23395	COG1733	regulation of RNA biosynthetic process
F8G81_RS23400	COG2910	NAD(P)H-binding
F8G81_RS23420	COG0406	alpha-ribazole phosphatase activity
F8G81_RS23425	COG0617	tRNA 3'-terminal CCA addition
F8G81_RS23445	COG0492	ferredoxin-NADP+ reductase activity
F8G81_RS23450	COG3118	belongs to the thioredoxin family
F8G81_RS23460	COG1192	Involved in chromosome partitioning
F8G81_RS23465	COG0357	Ribosomal RNA small subunit methyltransferase G
F8G81_RS23475	COG0706	membrane insertase activity
F8G81_RS23480	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F8G81_RS23485	COG0594	ribonuclease P activity
F8G81_RS23490	COG0230	Belongs to the bacterial ribosomal protein bL34 family