locus-tag	class	description
LFT45_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LFT45_RS00010	COG0592	DNA-directed DNA polymerase activity
LFT45_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LFT45_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LFT45_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
LFT45_RS00030	COG0187	DNA topoisomerase II activity
LFT45_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LFT45_RS00040	COG3266	domain, Protein
LFT45_RS00065	COG1215	transferase activity, transferring glycosyl groups
LFT45_RS00080	COG0705	Rhomboid family
LFT45_RS00085	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LFT45_RS00090	COG2818	Glycosylase
LFT45_RS00100	COG3764	Sortase (surface protein transpeptidase)
LFT45_RS00110	COG0515	serine threonine protein kinase
LFT45_RS00115	COG0515	serine threonine protein kinase
LFT45_RS00120	COG0768	penicillin binding
LFT45_RS00135	COG1716	ATPase activity
LFT45_RS00150	COG2801	Transposase and inactivated derivatives
LFT45_RS00150	COG3415	Transposase
LFT45_RS00165	COG0589	response to stress
LFT45_RS00170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LFT45_RS00175	COG0747	negative chemotaxis
LFT45_RS00185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LFT45_RS00190	COG0444	Belongs to the ABC transporter superfamily
LFT45_RS00195	COG4608	Belongs to the ABC transporter superfamily
LFT45_RS00205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LFT45_RS00210	COG4948	Mandelate Racemase Muconate Lactonizing
LFT45_RS00215	COG0583	DNA-binding transcription factor activity
LFT45_RS00220	COG1609	Transcriptional regulator
LFT45_RS00230	COG2176	DNA-directed DNA polymerase activity
LFT45_RS00240	COG2508	Transcriptional regulator
LFT45_RS00275	COG0673	inositol 2-dehydrogenase activity
LFT45_RS00280	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS00290	COG0477	Major facilitator Superfamily
LFT45_RS00295	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LFT45_RS00300	COG1609	Transcriptional regulator
LFT45_RS00305	COG0673	inositol 2-dehydrogenase activity
LFT45_RS00310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LFT45_RS00315	COG0477	Major facilitator Superfamily
LFT45_RS00320	COG1082	Xylose isomerase domain protein TIM barrel
LFT45_RS00325	COG1414	Transcriptional regulator
LFT45_RS00330	COG1175	transmembrane transport
LFT45_RS00370	COG5564	TIM-barrel signal transduction protein
LFT45_RS00380	COG0698	ribose 5-phosphate isomerase
LFT45_RS00385	COG1609	Transcriptional regulator
LFT45_RS00405	COG0395	ABC-type sugar transport system, permease component
LFT45_RS00410	COG1609	Transcriptional regulator
LFT45_RS00415	COG1621	beta-fructofuranosidase activity
LFT45_RS00440	COG1172	Belongs to the binding-protein-dependent transport system permease family
LFT45_RS00445	COG1129	ABC transporter
LFT45_RS00455	COG1609	Transcriptional regulator
LFT45_RS00475	COG1271	oxidase subunit
LFT45_RS00485	COG0579	oxidoreductase
LFT45_RS00520	COG0129	dihydroxy-acid dehydratase activity
LFT45_RS00540	COG0800	Aldolase
LFT45_RS00545	COG2186	Transcriptional regulator
LFT45_RS00555	COG1172	Belongs to the binding-protein-dependent transport system permease family
LFT45_RS00560	COG1172	Belongs to the binding-protein-dependent transport system permease family
LFT45_RS00575	COG2376	Dihydroxyacetone kinase
LFT45_RS00580	COG1461	Dihydroxyacetone kinase
LFT45_RS00585	COG0693	protein deglycase activity
LFT45_RS00600	COG4948	Mandelate Racemase Muconate Lactonizing
LFT45_RS00605	COG3386	PFAM SMP-30 Gluconolaconase
LFT45_RS00620	COG0693	protein deglycase activity
LFT45_RS00635	COG0673	inositol 2-dehydrogenase activity
LFT45_RS00645	COG1175	transmembrane transport
LFT45_RS00655	COG1063	alcohol dehydrogenase
LFT45_RS00665	COG1940	carbohydrate kinase activity
LFT45_RS00685	COG1410	methionine synthase
LFT45_RS00685	COG0646	methionine synthase
LFT45_RS00690	COG3845	ABC transporter
LFT45_RS00705	COG4948	Mandelate Racemase Muconate Lactonizing
LFT45_RS00715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LFT45_RS00720	COG0583	DNA-binding transcription factor activity
LFT45_RS00740	COG0589	response to stress
LFT45_RS00765	COG1609	Transcriptional regulator
LFT45_RS00775	COG0765	amino acid transport
LFT45_RS00780	COG1126	abc transporter atp-binding protein
LFT45_RS00785	COG0673	inositol 2-dehydrogenase activity
LFT45_RS00825	COG2271	Major facilitator Superfamily
LFT45_RS00835	COG2124	cytochrome p450
LFT45_RS00840	COG0679	Auxin Efflux Carrier
LFT45_RS00860	COG0346	lactoylglutathione lyase activity
LFT45_RS00865	COG1796	DNA polymerase
LFT45_RS00865	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LFT45_RS00875	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS00880	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LFT45_RS00890	COG0601	transmembrane transport
LFT45_RS00895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LFT45_RS00900	COG0444	Belongs to the ABC transporter superfamily
LFT45_RS00905	COG4608	Belongs to the ABC transporter superfamily
LFT45_RS00910	COG0667	Aldo Keto reductase
LFT45_RS00930	COG1349	DNA-binding transcription factor activity
LFT45_RS00945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LFT45_RS00965	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
LFT45_RS00980	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LFT45_RS00985	COG1309	transcriptional regulator
LFT45_RS00990	COG1846	Transcriptional regulator
LFT45_RS00995	COG0387	Pfam Sodium calcium exchanger
LFT45_RS01015	COG3960	tartronate-semialdehyde synthase activity
LFT45_RS01030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LFT45_RS01035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LFT45_RS01095	COG0531	amino acid
LFT45_RS01115	COG1609	Transcriptional regulator
LFT45_RS01125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LFT45_RS01130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_RS01135	COG0385	Bile acid
LFT45_RS01140	COG3706	GGDEF domain
LFT45_RS01150	COG0659	secondary active sulfate transmembrane transporter activity
LFT45_RS01210	COG1609	Transcriptional regulator
LFT45_RS01230	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LFT45_RS01235	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LFT45_RS01235	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LFT45_RS01240	COG2084	Dehydrogenase
LFT45_RS01260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LFT45_RS01265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LFT45_RS01270	COG2971	BadF BadG BcrA BcrD
LFT45_RS01275	COG2814	Major facilitator Superfamily
LFT45_RS01280	COG2188	Transcriptional regulator
LFT45_RS01310	COG1609	Transcriptional regulator
LFT45_RS01315	COG0477	Major facilitator Superfamily
LFT45_RS01320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LFT45_RS01325	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS01330	COG1250	3-hydroxyacyl-CoA dehydrogenase
LFT45_RS01340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LFT45_RS01350	COG0509	glycine decarboxylation via glycine cleavage system
LFT45_RS01355	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LFT45_RS01360	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LFT45_RS01360	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LFT45_RS01365	COG1113	amino acid transport
LFT45_RS01380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_RS01385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_RS01405	COG0765	amino acid transport
LFT45_RS01430	COG2132	Multicopper oxidase
LFT45_RS01440	COG1609	Transcriptional regulator
LFT45_RS01455	COG2160	L-arabinose isomerase activity
LFT45_RS01460	COG2017	converts alpha-aldose to the beta-anomer
LFT45_RS01465	COG1609	Transcriptional regulator
LFT45_RS01480	COG4214	carbohydrate transport
LFT45_RS01485	COG1129	ABC transporter
LFT45_RS01490	COG4213	ABC transporter substrate-binding protein
LFT45_RS01500	COG0697	spore germination
LFT45_RS01555	COG2814	Major facilitator Superfamily
LFT45_RS01560	COG1846	Transcriptional regulator
LFT45_RS01570	COG1175	transmembrane transport
LFT45_RS01575	COG0395	ABC-type sugar transport system, permease component
LFT45_RS01595	COG1940	carbohydrate kinase activity
LFT45_RS01600	COG0277	FAD linked oxidase domain protein
LFT45_RS01605	COG2115	Belongs to the xylose isomerase family
LFT45_RS01610	COG1070	Carbohydrate kinase
LFT45_RS01620	COG0673	inositol 2-dehydrogenase activity
LFT45_RS01635	COG0673	inositol 2-dehydrogenase activity
LFT45_RS01645	COG1175	transmembrane transport
LFT45_RS01650	COG1653	transport
LFT45_RS01655	COG1609	Transcriptional regulator
LFT45_RS01675	COG0584	glycerophosphoryl diester phosphodiesterase
LFT45_RS01690	COG0028	Belongs to the TPP enzyme family
LFT45_RS01695	COG1929	Belongs to the glycerate kinase type-1 family
LFT45_RS01705	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS01715	COG2233	PERMEase
LFT45_RS01720	COG0778	Nitroreductase
LFT45_RS01745	COG0154	amidase activity
LFT45_RS01750	COG0425	Belongs to the sulfur carrier protein TusA family
LFT45_RS01750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LFT45_RS01765	COG1597	lipid kinase activity
LFT45_RS01770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LFT45_RS01775	COG0561	phosphatase activity
LFT45_RS01790	COG2027	D-alanyl-D-alanine carboxypeptidase
LFT45_RS01800	COG0037	tRNA processing
LFT45_RS01810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LFT45_RS01815	COG0302	gtp cyclohydrolase
LFT45_RS01820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LFT45_RS01825	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LFT45_RS01855	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LFT45_RS01860	COG2814	Major facilitator Superfamily
LFT45_RS01875	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LFT45_RS01895	COG0823	Involved in the tonB-independent uptake of proteins
LFT45_RS01895	COG1506	peptidase
LFT45_RS01900	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LFT45_RS01905	COG2376	Dihydroxyacetone kinase
LFT45_RS01910	COG1461	Dihydroxyacetone kinase
LFT45_RS01915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LFT45_RS01915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LFT45_RS01915	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LFT45_RS01940	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LFT45_RS01945	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LFT45_RS01985	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_RS01990	COG0477	Major facilitator Superfamily
LFT45_RS02005	COG3971	2-oxopent-4-enoate hydratase activity
LFT45_RS02020	COG1802	Transcriptional regulator
LFT45_RS02045	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LFT45_RS02050	COG4977	sequence-specific DNA binding
LFT45_RS02060	COG3226	Transcriptional regulator
LFT45_RS02095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LFT45_RS02100	COG0306	phosphate transporter
LFT45_RS02125	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LFT45_RS02130	COG1609	Transcriptional regulator
LFT45_RS02140	COG0831	urea catabolic process
LFT45_RS02145	COG0832	Belongs to the urease beta subunit family
LFT45_RS02150	COG0804	urea catabolic process
LFT45_RS02155	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LFT45_RS02160	COG0830	nickel cation binding
LFT45_RS02165	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LFT45_RS02170	COG0829	nickel cation binding
LFT45_RS02175	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LFT45_RS02180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LFT45_RS02200	COG1609	Transcriptional regulator
LFT45_RS02210	COG1621	beta-fructofuranosidase activity
LFT45_RS02235	COG2890	protein-(glutamine-N5) methyltransferase activity
LFT45_RS02255	COG2261	transglycosylase associated protein
LFT45_RS02280	COG0667	Aldo Keto reductase
LFT45_RS02285	COG0656	L-ascorbic acid biosynthetic process
LFT45_RS02295	COG3360	Dodecin
LFT45_RS02300	COG2186	Transcriptional regulator
LFT45_RS02310	COG2084	Dehydrogenase
LFT45_RS02345	COG3486	L-lysine 6-monooxygenase (NADPH) activity
LFT45_RS02360	COG0300	oxidoreductase activity
LFT45_RS02370	COG0477	Major facilitator Superfamily
LFT45_RS02390	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LFT45_RS02410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LFT45_RS02410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LFT45_RS02410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LFT45_RS02415	COG1105	Belongs to the carbohydrate kinase PfkB family
LFT45_RS02420	COG1349	DNA-binding transcription factor activity
LFT45_RS02435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LFT45_RS02460	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LFT45_RS02470	COG2733	membrane
LFT45_RS02510	COG4122	O-methyltransferase activity
LFT45_RS02520	COG2132	Multicopper oxidase
LFT45_RS02530	COG0783	Belongs to the Dps family
LFT45_RS02540	COG1295	ribonuclease BN
LFT45_RS02560	COG1191	sigma factor activity
LFT45_RS02565	COG0859	PFAM glycosyl transferase family 9
LFT45_RS02570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LFT45_RS02575	COG0859	PFAM glycosyl transferase family 9
LFT45_RS02585	COG0438	transferase activity, transferring glycosyl groups
LFT45_RS02590	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LFT45_RS02595	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LFT45_RS02595	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LFT45_RS02610	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_RS02615	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LFT45_RS02615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LFT45_RS02625	COG0583	DNA-binding transcription factor activity
LFT45_RS02630	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS02635	COG1280	lysine exporter protein (LysE YggA)
LFT45_RS02655	COG4221	oxidoreductase activity
LFT45_RS02665	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LFT45_RS02690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LFT45_RS02695	COG0010	Belongs to the arginase family
LFT45_RS02700	COG2252	PERMEase
LFT45_RS02720	COG3848	Pyruvate phosphate dikinase
LFT45_RS02720	COG0574	Belongs to the PEP-utilizing enzyme family
LFT45_RS02760	COG0697	spore germination
LFT45_RS02790	COG1302	Protein conserved in bacteria
LFT45_RS02820	COG2182	Extracellular solute-binding protein
LFT45_RS02840	COG1609	Transcriptional regulator
LFT45_RS02860	COG1024	Enoyl-CoA hydratase
LFT45_RS02905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LFT45_RS02910	COG1960	acyl-CoA dehydrogenase activity
LFT45_RS02915	COG2318	DinB family
LFT45_RS02920	COG1278	Cold shock
LFT45_RS02930	COG2197	response regulator
LFT45_RS02935	COG4585	Histidine kinase
LFT45_RS02945	COG0666	response to abiotic stimulus
LFT45_RS02955	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LFT45_RS02970	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LFT45_RS02975	COG1609	Transcriptional regulator
LFT45_RS02985	COG0673	inositol 2-dehydrogenase activity
LFT45_RS02990	COG0747	negative chemotaxis
LFT45_RS03000	COG0444	Belongs to the ABC transporter superfamily
LFT45_RS03015	COG0673	inositol 2-dehydrogenase activity
LFT45_RS03020	COG1609	Transcriptional regulator
LFT45_RS03025	COG1904	glucuronate isomerase
LFT45_RS03030	COG0246	Mannitol dehydrogenase
LFT45_RS03035	COG3250	beta-galactosidase activity
LFT45_RS03045	COG4948	Mandelate Racemase Muconate Lactonizing
LFT45_RS03050	COG3265	gluconokinase activity
LFT45_RS03060	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LFT45_RS03105	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LFT45_RS03125	COG1832	CoA-binding protein
LFT45_RS03140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LFT45_RS03145	COG1832	CoA-binding protein
LFT45_RS03155	COG2315	Protein conserved in bacteria
LFT45_RS03160	COG4762	Protein conserved in bacteria
LFT45_RS03180	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LFT45_RS03185	COG0047	phosphoribosylformylglycinamidine synthase activity
LFT45_RS03200	COG1404	Belongs to the peptidase S8 family
LFT45_RS03225	COG1846	Transcriptional regulator
LFT45_RS03245	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LFT45_RS03260	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LFT45_RS03275	COG1196	nuclear chromosome segregation
LFT45_RS03275	COG0739	heme binding
LFT45_RS03275	COG0741	lytic transglycosylase activity
LFT45_RS03280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LFT45_RS03285	COG0438	transferase activity, transferring glycosyl groups
LFT45_RS03315	COG0438	transferase activity, transferring glycosyl groups
LFT45_RS03325	COG0673	inositol 2-dehydrogenase activity
LFT45_RS03330	COG0673	inositol 2-dehydrogenase activity
LFT45_RS03340	COG1940	carbohydrate kinase activity
LFT45_RS03345	COG0673	inositol 2-dehydrogenase activity
LFT45_RS03360	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LFT45_RS03370	COG1476	TRANSCRIPTIONal
LFT45_RS03380	COG0028	Belongs to the TPP enzyme family
LFT45_RS03395	COG0351	phosphomethylpyrimidine kinase
LFT45_RS03400	COG0477	Major facilitator Superfamily
LFT45_RS03415	COG0343	queuine tRNA-ribosyltransferase activity
LFT45_RS03445	COG1621	beta-fructofuranosidase activity
LFT45_RS03450	COG3842	ATPase activity
LFT45_RS03475	COG1960	acyl-CoA dehydrogenase activity
LFT45_RS03490	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LFT45_RS03495	COG1120	ATPase activity
LFT45_RS03500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LFT45_RS03505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LFT45_RS03575	COG0586	Pfam SNARE associated Golgi protein
LFT45_RS03585	COG0564	pseudouridine synthase activity
LFT45_RS03600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LFT45_RS03605	COG2364	Membrane
LFT45_RS03610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LFT45_RS03615	COG1201	RNA secondary structure unwinding
LFT45_RS03620	COG0723	plastoquinol--plastocyanin reductase activity
LFT45_RS03630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LFT45_RS03640	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LFT45_RS03680	COG0438	transferase activity, transferring glycosyl groups
LFT45_RS03695	COG0671	phosphoesterase, PA-phosphatase related
LFT45_RS03700	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LFT45_RS03730	COG2205	protein histidine kinase activity
LFT45_RS03735	COG0745	RESPONSE REGULATOR receiver
LFT45_RS03750	COG2062	phosphohistidine phosphatase, SixA
LFT45_RS03760	COG1309	transcriptional regulator
LFT45_RS03765	COG1511	domain protein
LFT45_RS03780	COG1802	Transcriptional regulator
LFT45_RS03790	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LFT45_RS03795	COG1017	nitric oxide dioxygenase activity
LFT45_RS03795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LFT45_RS03810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LFT45_RS03815	COG0514	ATP-dependent DNA helicase (RecQ)
LFT45_RS03820	COG2814	Major facilitator Superfamily
LFT45_RS03825	COG2801	Transposase and inactivated derivatives
LFT45_RS03825	COG3415	Transposase
LFT45_RS03835	COG1505	serine-type exopeptidase activity
LFT45_RS03855	COG0604	alcohol dehydrogenase
LFT45_RS03865	COG0577	efflux transmembrane transporter activity
LFT45_RS03865	COG1136	(ABC) transporter
LFT45_RS03875	COG1966	Carbon starvation protein
LFT45_RS03900	COG0656	L-ascorbic acid biosynthetic process
LFT45_RS03920	COG2261	transglycosylase associated protein
LFT45_RS03945	COG3655	Transcriptional regulator
LFT45_RS03990	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LFT45_RS03995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LFT45_RS04015	COG0588	phosphoglycerate mutase activity
LFT45_RS04025	COG5002	protein histidine kinase activity
LFT45_RS04045	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LFT45_RS04050	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LFT45_RS04060	COG0215	cysteine-tRNA ligase activity
LFT45_RS04095	COG0366	Alpha amylase catalytic
LFT45_RS04105	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LFT45_RS04125	COG1280	lysine exporter protein (LysE YggA)
LFT45_RS04130	COG2826	transposase and inactivated derivatives, IS30 family
LFT45_RS04140	COG1609	Transcriptional regulator
LFT45_RS04145	COG0366	Alpha amylase catalytic
LFT45_RS04150	COG0277	FAD linked oxidase domain protein
LFT45_RS04155	COG0402	S-adenosylhomocysteine deaminase activity
LFT45_RS04165	COG3842	ATPase activity
LFT45_RS04305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LFT45_RS04350	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LFT45_RS04355	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LFT45_RS04365	COG2079	MmgE PrpD family protein
LFT45_RS04370	COG0028	Belongs to the TPP enzyme family
LFT45_RS04380	COG0183	Belongs to the thiolase family
LFT45_RS04435	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LFT45_RS04440	COG1063	alcohol dehydrogenase
LFT45_RS04465	COG1129	ABC transporter
LFT45_RS04480	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS04510	COG1414	Transcriptional regulator
LFT45_RS04520	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LFT45_RS04535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LFT45_RS04545	COG1414	Transcriptional regulator
LFT45_RS04565	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LFT45_RS04570	COG2079	MmgE PrpD family protein
LFT45_RS04585	COG1879	ABC-type sugar transport system periplasmic component
LFT45_RS04590	COG1129	ABC transporter
LFT45_RS04595	COG1172	Belongs to the binding-protein-dependent transport system permease family
LFT45_RS04600	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS04620	COG3547	Transposase (IS116 IS110 IS902 family)
LFT45_RS04640	COG0535	radical SAM domain protein
LFT45_RS04670	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LFT45_RS04690	COG0667	Aldo Keto reductase
LFT45_RS04695	COG3964	amidohydrolase
LFT45_RS04700	COG0567	Dehydrogenase, E1 component
LFT45_RS04705	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_RS04725	COG1960	acyl-CoA dehydrogenase activity
LFT45_RS04745	COG2851	Citrate transporter
LFT45_RS04750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LFT45_RS04755	COG2301	Belongs to the HpcH HpaI aldolase family
LFT45_RS04780	COG0583	DNA-binding transcription factor activity
LFT45_RS04790	COG1063	alcohol dehydrogenase
LFT45_RS04795	COG0583	DNA-binding transcription factor activity
LFT45_RS04805	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS04825	COG1129	ABC transporter
LFT45_RS04835	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_RS04840	COG2301	Belongs to the HpcH HpaI aldolase family
LFT45_RS04845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LFT45_RS04855	COG0477	Major facilitator Superfamily
LFT45_RS04870	COG0247	lactate metabolic process
LFT45_RS04870	COG0277	FAD linked oxidase domain protein
LFT45_RS04875	COG2271	Major facilitator Superfamily
LFT45_RS04885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LFT45_RS04890	COG0121	glutamine amidotransferase
LFT45_RS04900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LFT45_RS04910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LFT45_RS04920	COG2271	Major facilitator Superfamily
LFT45_RS04945	COG2957	Belongs to the agmatine deiminase family
LFT45_RS04950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LFT45_RS04955	COG0783	Belongs to the Dps family
LFT45_RS04960	COG0477	Major facilitator Superfamily
LFT45_RS04970	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LFT45_RS04970	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LFT45_RS04975	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LFT45_RS04980	COG0509	glycine decarboxylation via glycine cleavage system
LFT45_RS04985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LFT45_RS04995	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
LFT45_RS05015	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LFT45_RS05040	COG0459	protein refolding
LFT45_RS05045	COG0328	RNA-DNA hybrid ribonuclease activity
LFT45_RS05055	COG2205	protein histidine kinase activity
LFT45_RS05060	COG0745	RESPONSE REGULATOR receiver
LFT45_RS05065	COG1061	Type III restriction enzyme res subunit
LFT45_RS05080	COG1278	Cold shock
LFT45_RS05100	COG0739	heme binding
LFT45_RS05105	COG0791	NLP P60 protein
LFT45_RS05105	COG1388	LysM domain
LFT45_RS05105	COG3103	Sh3 type 3 domain protein
LFT45_RS05110	COG0791	NLP P60 protein
LFT45_RS05110	COG1388	LysM domain
LFT45_RS05110	COG3103	Sh3 type 3 domain protein
LFT45_RS05120	COG0746	molybdenum cofactor guanylyltransferase activity
LFT45_RS05135	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LFT45_RS05145	COG1126	abc transporter atp-binding protein
LFT45_RS05150	COG0765	amino acid transport
LFT45_RS05155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LFT45_RS05180	COG0488	(ABC) transporter
LFT45_RS05185	COG1132	(ABC) transporter
LFT45_RS05195	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LFT45_RS05220	COG0483	inositol monophosphate 1-phosphatase activity
LFT45_RS05235	COG0045	succinate-CoA ligase (ADP-forming) activity
LFT45_RS05250	COG1942	4-Oxalocrotonate Tautomerase
LFT45_RS05255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LFT45_RS05265	COG3962	Belongs to the TPP enzyme family
LFT45_RS05280	COG0673	inositol 2-dehydrogenase activity
LFT45_RS05285	COG1082	Xylose isomerase domain protein TIM barrel
LFT45_RS05290	COG2814	Major facilitator Superfamily
LFT45_RS05300	COG2814	Major facilitator Superfamily
LFT45_RS05305	COG3718	enzyme involved in inositol metabolism
LFT45_RS05310	COG2188	Transcriptional regulator
LFT45_RS05315	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LFT45_RS05325	COG2186	Transcriptional regulator
LFT45_RS05335	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS05365	COG1396	sequence-specific DNA binding
LFT45_RS05375	COG0028	Belongs to the TPP enzyme family
LFT45_RS05410	COG1401	restriction endodeoxyribonuclease activity
LFT45_RS05420	COG1309	transcriptional regulator
LFT45_RS05425	COG5002	protein histidine kinase activity
LFT45_RS05430	COG0745	RESPONSE REGULATOR receiver
LFT45_RS05465	COG1902	pentaerythritol trinitrate reductase activity
LFT45_RS05480	COG2376	Dihydroxyacetone kinase
LFT45_RS05485	COG0698	ribose 5-phosphate isomerase
LFT45_RS05490	COG1250	3-hydroxyacyl-CoA dehydrogenase
LFT45_RS05495	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS05500	COG2271	Major facilitator Superfamily
LFT45_RS05505	COG0149	triose-phosphate isomerase activity
LFT45_RS05560	COG3583	domain protein
LFT45_RS05570	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LFT45_RS05585	COG0667	Aldo Keto reductase
LFT45_RS05590	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS05605	COG0366	Alpha amylase catalytic
LFT45_RS05605	COG3103	Sh3 type 3 domain protein
LFT45_RS05620	COG1254	Belongs to the acylphosphatase family
LFT45_RS05635	COG1063	alcohol dehydrogenase
LFT45_RS05650	COG2353	YceI-like domain
LFT45_RS05675	COG0246	Mannitol dehydrogenase
LFT45_RS05680	COG0800	Aldolase
LFT45_RS05700	COG0640	Transcriptional regulator
LFT45_RS05710	COG0514	ATP-dependent DNA helicase (RecQ)
LFT45_RS05730	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS05735	COG1063	alcohol dehydrogenase
LFT45_RS05765	COG0300	oxidoreductase activity
LFT45_RS05785	COG0477	Major facilitator Superfamily
LFT45_RS05825	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LFT45_RS05855	COG2828	Protein conserved in bacteria
LFT45_RS05890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LFT45_RS05895	COG0531	amino acid
LFT45_RS05900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LFT45_RS05910	COG0477	Major facilitator Superfamily
LFT45_RS05945	COG0477	Major facilitator Superfamily
LFT45_RS06050	COG0328	RNA-DNA hybrid ribonuclease activity
LFT45_RS06085	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LFT45_RS06110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LFT45_RS06115	COG0477	Major facilitator Superfamily
LFT45_RS06145	COG2186	Transcriptional regulator
LFT45_RS06155	COG1070	Carbohydrate kinase
LFT45_RS06175	COG0395	ABC-type sugar transport system, permease component
LFT45_RS06180	COG1063	alcohol dehydrogenase
LFT45_RS06195	COG2337	Toxic component of a toxin-antitoxin (TA) module
LFT45_RS06205	COG3328	transposase activity
LFT45_RS06225	COG4942	peptidase
LFT45_RS06230	COG1733	regulation of RNA biosynthetic process
LFT45_RS06240	COG2207	Transcriptional regulator
LFT45_RS06240	COG3708	Transcriptional regulator
LFT45_RS06270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LFT45_RS06275	COG1113	amino acid transport
LFT45_RS06300	COG1215	transferase activity, transferring glycosyl groups
LFT45_RS06310	COG3387	PFAM Glycoside hydrolase 15-related
LFT45_RS06320	COG2072	flavoprotein involved in K transport
LFT45_RS06335	COG1914	H( )-stimulated, divalent metal cation uptake system
LFT45_RS06350	COG1278	Cold shock
LFT45_RS06370	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LFT45_RS06380	COG3265	gluconokinase activity
LFT45_RS06385	COG2610	gluconate transmembrane transporter activity
LFT45_RS06400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LFT45_RS06445	COG0515	serine threonine protein kinase
LFT45_RS06445	COG2815	serine threonine protein kinase
LFT45_RS06485	COG3300	MHYT domain
LFT45_RS06485	COG5001	Diguanylate cyclase
LFT45_RS06490	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LFT45_RS06505	COG2268	Band 7 protein
LFT45_RS06535	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
LFT45_RS06580	COG0477	Major facilitator Superfamily
LFT45_RS06585	COG0138	bifunctional purine biosynthesis protein purh
LFT45_RS06600	COG2838	Isocitrate dehydrogenase
LFT45_RS06620	COG0515	serine threonine protein kinase
LFT45_RS06635	COG0673	inositol 2-dehydrogenase activity
LFT45_RS06640	COG1136	(ABC) transporter
LFT45_RS06650	COG4213	ABC transporter substrate-binding protein
LFT45_RS06655	COG4214	carbohydrate transport
LFT45_RS06680	COG0531	amino acid
LFT45_RS06700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LFT45_RS06720	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LFT45_RS06725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LFT45_RS06730	COG4585	Histidine kinase
LFT45_RS06735	COG2197	response regulator
LFT45_RS06770	COG0180	Tryptophanyl-tRNA synthetase
LFT45_RS06790	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LFT45_RS06805	COG2009	succinate dehydrogenase
LFT45_RS06815	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LFT45_RS06815	COG1473	amidohydrolase
LFT45_RS06820	COG1846	Transcriptional regulator
LFT45_RS06825	COG1764	response to oxidative stress
LFT45_RS06830	COG2130	NADP-dependent
LFT45_RS06850	COG0586	Pfam SNARE associated Golgi protein
LFT45_RS06855	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LFT45_RS06860	COG3956	TIGRFAM MazG family protein
LFT45_RS06865	COG0148	phosphopyruvate hydratase activity
LFT45_RS06890	COG1252	NADH dehydrogenase
LFT45_RS06925	COG0559	Belongs to the binding-protein-dependent transport system permease family
LFT45_RS06935	COG2826	transposase and inactivated derivatives, IS30 family
LFT45_RS06940	COG0183	Belongs to the thiolase family
LFT45_RS06945	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LFT45_RS06955	COG1349	DNA-binding transcription factor activity
LFT45_RS06960	COG2017	converts alpha-aldose to the beta-anomer
LFT45_RS06970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LFT45_RS06980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LFT45_RS06990	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LFT45_RS07000	COG1331	Highly conserved protein containing a thioredoxin domain
LFT45_RS07010	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LFT45_RS07015	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LFT45_RS07065	COG0765	amino acid transport
LFT45_RS07070	COG1126	abc transporter atp-binding protein
LFT45_RS07075	COG0251	oxidation-reduction process
LFT45_RS07080	COG0114	fumarate hydratase activity
LFT45_RS07085	COG0288	reversible hydration of carbon dioxide
LFT45_RS07095	COG1494	fructose-1,6-bisphosphatase
LFT45_RS07110	COG1482	cell wall glycoprotein biosynthetic process
LFT45_RS07120	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LFT45_RS07170	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LFT45_RS07175	COG1376	ErfK ybiS ycfS ynhG family protein
LFT45_RS07215	COG0477	Major facilitator Superfamily
LFT45_RS07230	COG0714	Associated with various cellular activities
LFT45_RS07235	COG0084	hydrolase, TatD family'
LFT45_RS07240	COG3583	domain protein
LFT45_RS07245	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LFT45_RS07250	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LFT45_RS07255	COG0488	(ABC) transporter
LFT45_RS07260	COG1309	transcriptional regulator
LFT45_RS07270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LFT45_RS07280	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LFT45_RS07285	COG0193	aminoacyl-tRNA hydrolase activity
LFT45_RS07305	COG0822	iron-sulfur transferase activity
LFT45_RS07310	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LFT45_RS07325	COG0702	epimerase
LFT45_RS07345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LFT45_RS07360	COG1648	precorrin-2 dehydrogenase activity
LFT45_RS07360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LFT45_RS07365	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LFT45_RS07375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LFT45_RS07380	COG1959	2 iron, 2 sulfur cluster binding
LFT45_RS07410	COG0243	molybdopterin cofactor binding
LFT45_RS07415	COG2223	nitrite transmembrane transporter activity
LFT45_RS07420	COG0477	Major facilitator Superfamily
LFT45_RS07425	COG4770	biotin carboxylase activity
LFT45_RS07430	COG0424	maF-like protein
LFT45_RS07435	COG2409	Drug exporters of the RND superfamily
LFT45_RS07450	COG0596	Alpha beta hydrolase
LFT45_RS07455	COG1823	symporter activity
LFT45_RS07470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LFT45_RS07475	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS07480	COG0640	Transcriptional regulator
LFT45_RS07490	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LFT45_RS07490	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LFT45_RS07510	COG0714	Associated with various cellular activities
LFT45_RS07530	COG0631	protein serine/threonine phosphatase activity
LFT45_RS07550	COG1674	ftsk spoiiie
LFT45_RS07565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LFT45_RS07570	COG0483	inositol monophosphate 1-phosphatase activity
LFT45_RS07585	COG0251	oxidation-reduction process
LFT45_RS07595	COG4565	transcriptional regulatory protein
LFT45_RS07605	COG2851	Citrate transporter
LFT45_RS07610	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LFT45_RS07615	COG0154	amidase activity
LFT45_RS07620	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LFT45_RS07625	COG0583	DNA-binding transcription factor activity
LFT45_RS07630	COG1063	alcohol dehydrogenase
LFT45_RS07635	COG0156	8-amino-7-oxononanoate synthase activity
LFT45_RS07645	COG1228	amidohydrolase
LFT45_RS07655	COG0588	phosphoglycerate mutase activity
LFT45_RS07670	COG2873	o-acetylhomoserine
LFT45_RS07675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LFT45_RS07715	COG0400	carboxylic ester hydrolase activity
LFT45_RS07730	COG0423	glycine-tRNA ligase activity
LFT45_RS07770	COG0358	DNA primase activity
LFT45_RS07795	COG2814	Major facilitator Superfamily
LFT45_RS07805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LFT45_RS07815	COG0438	transferase activity, transferring glycosyl groups
LFT45_RS07840	COG0052	Belongs to the universal ribosomal protein uS2 family
LFT45_RS07845	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LFT45_RS07850	COG0528	UMP kinase activity
LFT45_RS07855	COG0233	cytoplasmic translational termination
LFT45_RS07870	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LFT45_RS07885	COG3275	phosphorelay sensor kinase activity
LFT45_RS07895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LFT45_RS07915	COG1522	sequence-specific DNA binding
LFT45_RS07925	COG0022	dehydrogenase e1 component
LFT45_RS07930	COG0508	dehydrogenase complex catalyzes the overall conversion of
LFT45_RS07940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LFT45_RS07950	COG1960	acyl-CoA dehydrogenase activity
LFT45_RS07980	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LFT45_RS07985	COG0750	zinc metalloprotease
LFT45_RS08005	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LFT45_RS08015	COG0442	prolyl-tRNA aminoacylation
LFT45_RS08030	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
LFT45_RS08045	COG0779	Required for maturation of 30S ribosomal subunits
LFT45_RS08060	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LFT45_RS08065	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LFT45_RS08090	COG0590	tRNA wobble adenosine to inosine editing
LFT45_RS08095	COG0436	Aminotransferase
LFT45_RS08100	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LFT45_RS08125	COG3483	tryptophan 2,3-dioxygenase activity
LFT45_RS08135	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LFT45_RS08140	COG1185	polyribonucleotide nucleotidyltransferase activity
LFT45_RS08145	COG0612	Peptidase, M16
LFT45_RS08185	COG0521	Mo-molybdopterin cofactor biosynthetic process
LFT45_RS08195	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LFT45_RS08240	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LFT45_RS08245	COG1674	ftsk spoiiie
LFT45_RS08255	COG1546	Belongs to the CinA family
LFT45_RS08255	COG1058	Belongs to the CinA family
LFT45_RS08260	COG1396	sequence-specific DNA binding
LFT45_RS08275	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LFT45_RS08280	COG2137	regulation of response to DNA damage stimulus
LFT45_RS08285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LFT45_RS08290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LFT45_RS08295	COG0697	spore germination
LFT45_RS08300	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LFT45_RS08305	COG2813	Specifically methylates the guanine in position
LFT45_RS08310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LFT45_RS08320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LFT45_RS08330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LFT45_RS08335	COG0131	Imidazoleglycerol-phosphate dehydratase
LFT45_RS08340	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LFT45_RS08350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LFT45_RS08370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LFT45_RS08375	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LFT45_RS08380	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LFT45_RS08385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LFT45_RS08400	COG2814	Major facilitator Superfamily
LFT45_RS08410	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LFT45_RS08415	COG2011	ABC-type metal ion transport system permease component
LFT45_RS08420	COG1464	Belongs to the NlpA lipoprotein family
LFT45_RS08430	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LFT45_RS08445	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LFT45_RS08450	COG0072	phenylalanine-tRNA ligase activity
LFT45_RS08450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LFT45_RS08455	COG0464	growth
LFT45_RS08480	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LFT45_RS08485	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LFT45_RS08490	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LFT45_RS08495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LFT45_RS08500	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LFT45_RS08505	COG1438	arginine binding
LFT45_RS08510	COG0137	argininosuccinate synthase activity
LFT45_RS08515	COG0165	Argininosuccinate lyase
LFT45_RS08525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LFT45_RS08525	COG2169	Transcriptional regulator
LFT45_RS08535	COG2094	Belongs to the DNA glycosylase MPG family
LFT45_RS08540	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LFT45_RS08550	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LFT45_RS08575	COG1276	copper resistance
LFT45_RS08575	COG2372	response to copper ion
LFT45_RS08590	COG0647	UMP catabolic process
LFT45_RS08605	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LFT45_RS08610	COG0497	DNA recombination
LFT45_RS08615	COG0504	CTP synthase activity
LFT45_RS08650	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LFT45_RS08655	COG2079	MmgE PrpD family protein
LFT45_RS08675	COG3290	protein histidine kinase activity
LFT45_RS08680	COG1301	dicarboxylic acid transport
LFT45_RS08690	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LFT45_RS08695	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LFT45_RS08710	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LFT45_RS08720	COG1160	GTP binding
LFT45_RS08730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LFT45_RS08735	COG0509	glycine decarboxylation via glycine cleavage system
LFT45_RS08740	COG1716	ATPase activity
LFT45_RS08765	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LFT45_RS08780	COG1940	carbohydrate kinase activity
LFT45_RS08805	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LFT45_RS08810	COG0515	serine threonine protein kinase
LFT45_RS08810	COG2815	serine threonine protein kinase
LFT45_RS08815	COG1388	LysM domain
LFT45_RS08815	COG3942	CHAP domain
LFT45_RS08825	COG0142	geranyltranstransferase activity
LFT45_RS08835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LFT45_RS08845	COG2001	Belongs to the MraZ family
LFT45_RS08850	COG0275	rRNA processing
LFT45_RS08860	COG0768	penicillin binding
LFT45_RS08870	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LFT45_RS08875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LFT45_RS08880	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LFT45_RS08890	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LFT45_RS08895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LFT45_RS08905	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LFT45_RS08915	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LFT45_RS08920	COG1799	cell septum assembly
LFT45_RS08935	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LFT45_RS08945	COG0587	DNA-directed DNA polymerase activity
LFT45_RS08960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LFT45_RS08965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LFT45_RS08985	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LFT45_RS08990	COG0174	glutamine synthetase
LFT45_RS08995	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LFT45_RS09035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LFT45_RS09040	COG0321	lipoyl(octanoyl) transferase activity
LFT45_RS09050	COG1090	epimerase
LFT45_RS09055	COG0793	Belongs to the peptidase S41A family
LFT45_RS09055	COG4946	Tricorn protease homolog
LFT45_RS09060	COG1764	response to oxidative stress
LFT45_RS09070	COG0508	dehydrogenase complex catalyzes the overall conversion of
LFT45_RS09075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LFT45_RS09080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LFT45_RS09100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LFT45_RS09135	COG1271	oxidase subunit
LFT45_RS09140	COG1294	oxidase, subunit
LFT45_RS09145	COG4988	ABC transporter
LFT45_RS09150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LFT45_RS09170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LFT45_RS09175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LFT45_RS09175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LFT45_RS09190	COG1435	thymidine kinase activity
LFT45_RS09210	COG0756	dUTP diphosphatase activity
LFT45_RS09235	COG0569	domain protein
LFT45_RS09240	COG0531	amino acid
LFT45_RS09245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LFT45_RS09250	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LFT45_RS09255	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LFT45_RS09275	COG0667	Aldo Keto reductase
LFT45_RS09295	COG1122	ATPase activity
LFT45_RS09300	COG1024	Enoyl-CoA hydratase
LFT45_RS09300	COG1250	3-hydroxyacyl-CoA dehydrogenase
LFT45_RS09310	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LFT45_RS09315	COG2837	iron assimilation
LFT45_RS09325	COG0672	)-iron permease
LFT45_RS09350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LFT45_RS09365	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LFT45_RS09425	COG0242	peptide deformylase activity
LFT45_RS09430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LFT45_RS09440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LFT45_RS09460	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LFT45_RS09460	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LFT45_RS09465	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LFT45_RS09465	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LFT45_RS09470	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LFT45_RS09475	COG0140	phosphoribosyl-ATP diphosphatase activity
LFT45_RS09480	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LFT45_RS09485	COG0107	imidazoleglycerol-phosphate synthase activity
LFT45_RS09495	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LFT45_RS09515	COG0134	indole-3-glycerol-phosphate synthase activity
LFT45_RS09520	COG0133	tryptophan synthase activity
LFT45_RS09525	COG0159	tryptophan synthase activity
LFT45_RS09530	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LFT45_RS09535	COG0067	glutamate synthase
LFT45_RS09535	COG0070	glutamate synthase
LFT45_RS09535	COG0069	glutamate synthase activity
LFT45_RS09650	COG1196	nuclear chromosome segregation
LFT45_RS09685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LFT45_RS09695	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_RS09700	COG3119	arylsulfatase activity
LFT45_RS09705	COG2271	Major facilitator Superfamily
LFT45_RS09720	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LFT45_RS09755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_RS09760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_RS09770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_RS09810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LFT45_RS09825	COG1846	Transcriptional regulator
LFT45_RS09835	COG3654	unkown
LFT45_RS09975	COG2026	Addiction module toxin, RelE StbE family
LFT45_RS09980	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LFT45_RS09985	COG1131	(ABC) transporter
LFT45_RS09990	COG3559	Exporter of polyketide antibiotics
LFT45_RS10000	COG2132	Multicopper oxidase
LFT45_RS10015	COG2814	Major facilitator Superfamily
LFT45_RS10025	COG1349	DNA-binding transcription factor activity
LFT45_RS10030	COG1063	alcohol dehydrogenase
LFT45_RS10040	COG1129	ABC transporter
LFT45_RS10045	COG1172	Belongs to the binding-protein-dependent transport system permease family
LFT45_RS10050	COG1879	ABC-type sugar transport system periplasmic component
LFT45_RS10075	COG4249	Peptidase C14 caspase catalytic subunit p20
LFT45_RS10075	COG2319	Wd-40 repeat
LFT45_RS10095	COG3328	transposase activity
LFT45_RS10100	COG3547	Transposase (IS116 IS110 IS902 family)
LFT45_RS10110	COG3485	protocatechuate 3,4-dioxygenase
LFT45_RS10115	COG4638	Rieske (2fe-2S)
LFT45_RS10120	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LFT45_RS10150	COG0583	DNA-binding transcription factor activity
LFT45_RS10155	COG2814	Major facilitator Superfamily
LFT45_RS10175	COG3387	PFAM Glycoside hydrolase 15-related
LFT45_RS10195	COG1063	alcohol dehydrogenase
LFT45_RS10260	COG1802	Transcriptional regulator
LFT45_RS10265	COG0477	Major facilitator Superfamily
LFT45_RS10305	COG3321	synthase
LFT45_RS10305	COG0604	alcohol dehydrogenase
LFT45_RS10310	COG2267	carboxylic ester hydrolase activity
LFT45_RS10320	COG2826	transposase and inactivated derivatives, IS30 family
LFT45_RS10335	COG3328	transposase activity
LFT45_RS10340	COG2814	Major facilitator Superfamily
LFT45_RS10345	COG0745	RESPONSE REGULATOR receiver
LFT45_RS10350	COG5002	protein histidine kinase activity
LFT45_RS10410	COG0583	DNA-binding transcription factor activity
LFT45_RS10425	COG0251	oxidation-reduction process
LFT45_RS10455	COG2814	Major facilitator Superfamily
LFT45_RS10470	COG2319	Wd-40 repeat
LFT45_RS10470	COG4249	Peptidase C14 caspase catalytic subunit p20
LFT45_RS10525	COG4638	Rieske (2fe-2S)
LFT45_RS10530	COG0583	DNA-binding transcription factor activity
LFT45_RS10540	COG2201	protein-glutamate methylesterase activity
LFT45_RS10550	COG3621	Patatin-like phospholipase
LFT45_RS10560	COG0842	Transport permease protein
LFT45_RS10560	COG1131	(ABC) transporter
LFT45_RS10560	COG1716	ATPase activity
LFT45_RS10580	COG3387	PFAM Glycoside hydrolase 15-related
LFT45_RS10585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LFT45_RS10630	COG1619	proteins homologs of microcin C7 resistance protein MccF
LFT45_RS10655	COG3321	synthase
LFT45_RS10655	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS10655	COG0604	alcohol dehydrogenase
LFT45_RS10660	COG1793	dna ligase
LFT45_RS10695	COG0709	Synthesizes selenophosphate from selenide and ATP
LFT45_RS10705	COG0437	4 iron, 4 sulfur cluster binding
LFT45_RS10715	COG0492	ferredoxin-NADP+ reductase activity
LFT45_RS10720	COG0596	Alpha beta hydrolase
LFT45_RS10740	COG1252	NADH dehydrogenase
LFT45_RS10750	COG2814	Major facilitator Superfamily
LFT45_RS10775	COG1879	ABC-type sugar transport system periplasmic component
LFT45_RS10785	COG1172	Belongs to the binding-protein-dependent transport system permease family
LFT45_RS10790	COG1129	ABC transporter
LFT45_RS10795	COG1802	Transcriptional regulator
LFT45_RS10805	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_RS10815	COG0506	proline dehydrogenase activity
LFT45_RS10825	COG0765	amino acid transport
LFT45_RS10830	COG0765	amino acid transport
LFT45_RS10840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LFT45_RS10850	COG0583	DNA-binding transcription factor activity
LFT45_RS10885	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LFT45_RS10890	COG2124	cytochrome p450
LFT45_RS10895	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LFT45_RS10900	COG0156	8-amino-7-oxononanoate synthase activity
LFT45_RS10905	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LFT45_RS10915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LFT45_RS10960	COG0174	glutamine synthetase
LFT45_RS10975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LFT45_RS10990	COG0405	Gamma-glutamyltransferase
LFT45_RS11010	COG1752	Esterase of the alpha-beta hydrolase superfamily
LFT45_RS11010	COG1752	Esterase of the alpha-beta hydrolase superfamily
LFT45_RS11030	COG1643	Atp-dependent helicase
LFT45_RS11035	COG0438	transferase activity, transferring glycosyl groups
LFT45_RS11065	COG0009	L-threonylcarbamoyladenylate synthase
LFT45_RS11115	COG2050	protein possibly involved in aromatic compounds catabolism
LFT45_RS11130	COG0539	negative regulation of cytoplasmic translation
LFT45_RS11135	COG0693	protein deglycase activity
LFT45_RS11140	COG1739	Uncharacterized protein family UPF0029
LFT45_RS11145	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LFT45_RS11145	COG0237	dephospho-CoA kinase activity
LFT45_RS11150	COG0556	nucleotide-excision repair
LFT45_RS11180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LFT45_RS11195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LFT45_RS11210	COG4106	trans-aconitate 2-methyltransferase activity
LFT45_RS11245	COG0322	excinuclease ABC activity
LFT45_RS11250	COG1660	Displays ATPase and GTPase activities
LFT45_RS11255	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LFT45_RS11260	COG1481	regulation of sporulation
LFT45_RS11265	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LFT45_RS11270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LFT45_RS11275	COG0126	phosphoglycerate kinase activity
LFT45_RS11280	COG0149	triose-phosphate isomerase activity
LFT45_RS11285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LFT45_RS11295	COG0363	glucosamine-6-phosphate deaminase activity
LFT45_RS11310	COG0166	Belongs to the GPI family
LFT45_RS11315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LFT45_RS11325	COG0109	protoheme IX farnesyltransferase activity
LFT45_RS11330	COG1612	heme a metabolic process
LFT45_RS11340	COG1131	(ABC) transporter
LFT45_RS11355	COG0719	Fe-S assembly protein
LFT45_RS11365	COG0396	ATPase activity
LFT45_RS11370	COG2151	metal-sulfur cluster biosynthetic enzyme
LFT45_RS11380	COG0318	PFAM AMP-dependent synthetase and ligase
LFT45_RS11385	COG0183	Belongs to the thiolase family
LFT45_RS11400	COG2267	carboxylic ester hydrolase activity
LFT45_RS11475	COG1122	ATPase activity
LFT45_RS11480	COG1268	BioY protein
LFT45_RS11485	COG0488	(ABC) transporter
LFT45_RS11495	COG1357	PFAM Pentapeptide repeats (8 copies)
LFT45_RS11525	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS11530	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS11540	COG0560	Phosphoserine phosphatase
LFT45_RS11540	COG3830	Belongs to the UPF0237 family
LFT45_RS11545	COG0671	phosphoesterase, PA-phosphatase related
LFT45_RS11550	COG0477	Major facilitator Superfamily
LFT45_RS11565	COG1119	ATPase activity
LFT45_RS11580	COG0254	rRNA binding
LFT45_RS11595	COG2855	membrane
LFT45_RS11600	COG2308	Evidence 4 Homologs of previously reported genes of
LFT45_RS11630	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LFT45_RS11635	COG0297	glycogen (starch) synthase activity
LFT45_RS11645	COG1309	transcriptional regulator
LFT45_RS11655	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS11670	COG0435	Glutathione S-transferase
LFT45_RS11695	COG1929	Belongs to the glycerate kinase type-1 family
LFT45_RS11700	COG1301	dicarboxylic acid transport
LFT45_RS11710	COG0583	DNA-binding transcription factor activity
LFT45_RS11755	COG2801	Transposase and inactivated derivatives
LFT45_RS11785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LFT45_RS11805	COG0656	L-ascorbic acid biosynthetic process
LFT45_RS11810	COG1968	undecaprenyl-diphosphatase activity
LFT45_RS11815	COG0215	cysteine-tRNA ligase activity
LFT45_RS11825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LFT45_RS11830	COG1994	Peptidase M50
LFT45_RS11830	COG0517	IMP dehydrogenase activity
LFT45_RS11840	COG1222	aaa ATPase
LFT45_RS11845	COG4122	O-methyltransferase activity
LFT45_RS11855	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LFT45_RS11860	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LFT45_RS11865	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LFT45_RS11870	COG0545	Peptidyl-prolyl cis-trans isomerase
LFT45_RS11890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LFT45_RS11895	COG0805	protein transport
LFT45_RS11900	COG4581	dead DEAH box helicase
LFT45_RS11905	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LFT45_RS11910	COG1216	Glycosyl transferase, family 2
LFT45_RS11935	COG1506	peptidase
LFT45_RS11935	COG4946	Tricorn protease homolog
LFT45_RS11935	COG0823	Involved in the tonB-independent uptake of proteins
LFT45_RS11940	COG0242	peptide deformylase activity
LFT45_RS11945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LFT45_RS11950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LFT45_RS11955	COG3424	synthase
LFT45_RS11970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LFT45_RS11990	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LFT45_RS12010	COG2066	Belongs to the glutaminase family
LFT45_RS12020	COG0028	Belongs to the TPP enzyme family
LFT45_RS12025	COG1280	lysine exporter protein (LysE YggA)
LFT45_RS12045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LFT45_RS12050	COG1845	cytochrome c oxidase, subunit III
LFT45_RS12055	COG2010	Cytochrome c
LFT45_RS12060	COG0723	plastoquinol--plastocyanin reductase activity
LFT45_RS12065	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LFT45_RS12070	COG2188	Transcriptional regulator
LFT45_RS12075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LFT45_RS12085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LFT45_RS12090	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LFT45_RS12110	COG0167	dihydroorotate dehydrogenase activity
LFT45_RS12120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LFT45_RS12125	COG1381	Involved in DNA repair and RecF pathway recombination
LFT45_RS12130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LFT45_RS12135	COG3590	peptidase
LFT45_RS12140	COG1316	TRANSCRIPTIONal
LFT45_RS12145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LFT45_RS12155	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LFT45_RS12170	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LFT45_RS12175	COG0484	heat shock protein binding
LFT45_RS12180	COG1420	regulation of RNA biosynthetic process
LFT45_RS12195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LFT45_RS12200	COG0481	GTPase activity
LFT45_RS12210	COG0268	Binds directly to 16S ribosomal RNA
LFT45_RS12245	COG1307	EDD domain protein, DegV family
LFT45_RS12250	COG0495	leucyl-tRNA aminoacylation
LFT45_RS12255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LFT45_RS12260	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LFT45_RS12265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LFT45_RS12270	COG2390	Transcriptional regulator
LFT45_RS12280	COG0656	L-ascorbic acid biosynthetic process
LFT45_RS12290	COG0438	transferase activity, transferring glycosyl groups
LFT45_RS12300	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LFT45_RS12310	COG1758	RNA polymerase activity
LFT45_RS12315	COG0194	GDP metabolic process
LFT45_RS12320	COG0194	GDP metabolic process
LFT45_RS12325	COG0284	orotidine-5'-phosphate decarboxylase activity
LFT45_RS12330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LFT45_RS12335	COG0505	Belongs to the CarA family
LFT45_RS12345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LFT45_RS12350	COG0540	Belongs to the ATCase OTCase family
LFT45_RS12355	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LFT45_RS12365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LFT45_RS12370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LFT45_RS12380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LFT45_RS12385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LFT45_RS12390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LFT45_RS12395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LFT45_RS12405	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LFT45_RS12410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LFT45_RS12425	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LFT45_RS12460	COG1053	succinate dehydrogenase
LFT45_RS12465	COG1414	Transcriptional regulator
LFT45_RS12475	COG1053	succinate dehydrogenase
LFT45_RS12485	COG0477	Major facilitator Superfamily
LFT45_RS12500	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LFT45_RS12510	COG0124	histidyl-tRNA synthetase
LFT45_RS12520	COG1196	nuclear chromosome segregation
LFT45_RS12530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LFT45_RS12535	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LFT45_RS12540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LFT45_RS12550	COG2255	four-way junction helicase activity
LFT45_RS12555	COG0632	four-way junction helicase activity
LFT45_RS12560	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LFT45_RS12565	COG0217	transcriptional regulatory protein
LFT45_RS12570	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LFT45_RS12575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LFT45_RS12595	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LFT45_RS12600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LFT45_RS12610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LFT45_RS12615	COG0587	DNA-directed DNA polymerase activity
LFT45_RS12630	COG0077	Prephenate dehydratase
LFT45_RS12630	COG1605	Chorismate mutase
LFT45_RS12640	COG2135	peptidase activity
LFT45_RS12765	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LFT45_RS12780	COG1234	tRNA 3'-trailer cleavage
LFT45_RS12785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LFT45_RS12800	COG0412	Dienelactone hydrolase
LFT45_RS12810	COG0656	L-ascorbic acid biosynthetic process
LFT45_RS12840	COG0494	nUDIX hydrolase
LFT45_RS12850	COG3201	nicotinamide mononucleotide transporter
LFT45_RS12860	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LFT45_RS12865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LFT45_RS12870	COG1780	Probably involved in ribonucleotide reductase function
LFT45_RS12880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LFT45_RS12890	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
LFT45_RS12905	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LFT45_RS12925	COG1846	Transcriptional regulator
LFT45_RS12925	COG1940	carbohydrate kinase activity
LFT45_RS12930	COG2813	Specifically methylates the guanine in position
LFT45_RS12960	COG0799	negative regulation of ribosome biogenesis
LFT45_RS12970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LFT45_RS12980	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LFT45_RS12985	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LFT45_RS12990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LFT45_RS12995	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LFT45_RS13000	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LFT45_RS13005	COG0351	phosphomethylpyrimidine kinase
LFT45_RS13005	COG0352	thiamine-phosphate diphosphorylase activity
LFT45_RS13005	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LFT45_RS13010	COG1530	ribonuclease E activity
LFT45_RS13020	COG0105	UTP biosynthetic process
LFT45_RS13030	COG0285	dihydrofolate synthase activity
LFT45_RS13035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LFT45_RS13050	COG3189	MarR family transcriptional regulator
LFT45_RS13055	COG0525	valine-tRNA ligase activity
LFT45_RS13060	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LFT45_RS13065	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LFT45_RS13070	COG0740	serine-type endopeptidase activity
LFT45_RS13075	COG0740	serine-type endopeptidase activity
LFT45_RS13080	COG0544	peptidyl-prolyl cis-trans isomerase activity
LFT45_RS13120	COG0668	transmembrane transport
LFT45_RS13135	COG1946	Acyl-CoA thioesterase
LFT45_RS13150	COG0629	single-stranded DNA binding
LFT45_RS13175	COG1082	Xylose isomerase domain protein TIM barrel
LFT45_RS13185	COG0673	inositol 2-dehydrogenase activity
LFT45_RS13190	COG1609	Transcriptional regulator
LFT45_RS13220	COG0242	peptide deformylase activity
LFT45_RS13255	COG3022	response to hydroperoxide
LFT45_RS13265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LFT45_RS13270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LFT45_RS13280	COG1045	serine acetyltransferase
LFT45_RS13285	COG0300	oxidoreductase activity
LFT45_RS13290	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LFT45_RS13300	COG1063	alcohol dehydrogenase
LFT45_RS13305	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS13310	COG2084	Dehydrogenase
LFT45_RS13315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LFT45_RS13320	COG0477	Major facilitator Superfamily
LFT45_RS13355	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LFT45_RS13370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LFT45_RS13375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LFT45_RS13380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LFT45_RS13390	COG4974	Belongs to the 'phage' integrase family
LFT45_RS13405	COG0792	nuclease activity
LFT45_RS13415	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LFT45_RS13425	COG0681	Belongs to the peptidase S26 family
LFT45_RS13430	COG0335	large ribosomal subunit rRNA binding
LFT45_RS13435	COG0336	Belongs to the RNA methyltransferase TrmD family
LFT45_RS13440	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LFT45_RS13445	COG1837	Belongs to the UPF0109 family
LFT45_RS13450	COG0228	four-way junction DNA binding
LFT45_RS13460	COG2514	catechol 2,3-dioxygenase activity
LFT45_RS13485	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LFT45_RS13510	COG1196	nuclear chromosome segregation
LFT45_RS13515	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LFT45_RS13520	COG0571	ribonuclease III activity
LFT45_RS13525	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LFT45_RS13535	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LFT45_RS13550	COG0742	ribosomal rna small subunit methyltransferase
LFT45_RS13575	COG1181	Belongs to the D-alanine--D-alanine ligase family
LFT45_RS13580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LFT45_RS13590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LFT45_RS13595	COG0066	3-isopropylmalate dehydratase activity
LFT45_RS13600	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LFT45_RS13605	COG1414	Transcriptional regulator
LFT45_RS13625	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LFT45_RS13650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LFT45_RS13655	COG0179	Fumarylacetoacetate (FAA) hydrolase
LFT45_RS13665	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LFT45_RS13670	COG0473	3-isopropylmalate dehydrogenase activity
LFT45_RS13690	COG0577	efflux transmembrane transporter activity
LFT45_RS13690	COG1136	(ABC) transporter
LFT45_RS13705	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LFT45_RS13710	COG0440	acetolactate synthase activity
LFT45_RS13720	COG0129	dihydroxy-acid dehydratase activity
LFT45_RS13725	COG0228	four-way junction DNA binding
LFT45_RS13745	COG1609	Transcriptional regulator
LFT45_RS13750	COG0673	inositol 2-dehydrogenase activity
LFT45_RS13755	COG0673	inositol 2-dehydrogenase activity
LFT45_RS13760	COG0673	inositol 2-dehydrogenase activity
LFT45_RS13770	COG1172	Belongs to the binding-protein-dependent transport system permease family
LFT45_RS13785	COG0673	inositol 2-dehydrogenase activity
LFT45_RS13790	COG1609	Transcriptional regulator
LFT45_RS13815	COG0747	negative chemotaxis
LFT45_RS13820	COG0579	oxidoreductase
LFT45_RS13825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LFT45_RS13835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_RS13845	COG1305	Transglutaminase-like
LFT45_RS13860	COG0179	Fumarylacetoacetate (FAA) hydrolase
LFT45_RS13865	COG1104	cysteine desulfurase activity
LFT45_RS13875	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LFT45_RS13880	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LFT45_RS13890	COG1113	amino acid transport
LFT45_RS13905	COG0477	Major facilitator Superfamily
LFT45_RS13910	COG1414	Transcriptional regulator
LFT45_RS13920	COG0419	ATPase involved in DNA repair
LFT45_RS13925	COG0420	3'-5' exonuclease activity
LFT45_RS13950	COG0586	Pfam SNARE associated Golgi protein
LFT45_RS13955	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LFT45_RS13960	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LFT45_RS13965	COG1234	tRNA 3'-trailer cleavage
LFT45_RS13970	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LFT45_RS13980	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LFT45_RS13990	COG1335	isochorismatase
LFT45_RS14005	COG0363	glucosamine-6-phosphate deaminase activity
LFT45_RS14020	COG1902	pentaerythritol trinitrate reductase activity
LFT45_RS14035	COG0628	permease
LFT45_RS14050	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
LFT45_RS14065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LFT45_RS14070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LFT45_RS14075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LFT45_RS14080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LFT45_RS14085	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LFT45_RS14090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LFT45_RS14095	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LFT45_RS14100	COG0356	it plays a direct role in the translocation of protons across the membrane
LFT45_RS14115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LFT45_RS14135	COG2890	protein-(glutamine-N5) methyltransferase activity
LFT45_RS14140	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LFT45_RS14150	COG0083	homoserine kinase activity
LFT45_RS14155	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LFT45_RS14160	COG0460	homoserine dehydrogenase
LFT45_RS14165	COG0019	diaminopimelate decarboxylase activity
LFT45_RS14170	COG0018	arginyl-trna synthetase
LFT45_RS14215	COG1643	Atp-dependent helicase
LFT45_RS14225	COG0537	adenosine 5'-monophosphoramidase activity
LFT45_RS14230	COG1064	alcohol dehydrogenase
LFT45_RS14240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LFT45_RS14260	COG1121	(ABC) transporter
LFT45_RS14280	COG0508	dehydrogenase complex catalyzes the overall conversion of
LFT45_RS14280	COG0567	Dehydrogenase, E1 component
LFT45_RS14305	COG1595	DNA-templated transcription, initiation
LFT45_RS14315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LFT45_RS14325	COG0483	inositol monophosphate 1-phosphatase activity
LFT45_RS14330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LFT45_RS14345	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LFT45_RS14350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LFT45_RS14375	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LFT45_RS14390	COG2884	Cell division ATP-binding protein ftsE
LFT45_RS14395	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LFT45_RS14450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LFT45_RS14455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LFT45_RS14465	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LFT45_RS14470	COG2089	acid synthase
LFT45_RS14480	COG1083	cytidylyl-transferase
LFT45_RS14500	COG1216	Glycosyl transferase, family 2
LFT45_RS14525	COG1216	Glycosyl transferase, family 2
LFT45_RS14555	COG2902	Dehydrogenase
LFT45_RS14590	COG0653	protein targeting
LFT45_RS14595	COG3214	Protein conserved in bacteria
LFT45_RS14600	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LFT45_RS14610	COG5401	PFAM Sporulation and spore germination
LFT45_RS14615	COG5000	phosphorelay sensor kinase activity
LFT45_RS14615	COG5002	protein histidine kinase activity
LFT45_RS14640	COG0714	Associated with various cellular activities
LFT45_RS14680	COG0601	transmembrane transport
LFT45_RS14690	COG0482	sulfurtransferase activity
LFT45_RS14720	COG0484	heat shock protein binding
LFT45_RS14725	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LFT45_RS14730	COG1595	DNA-templated transcription, initiation
LFT45_RS14750	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LFT45_RS14760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LFT45_RS14770	COG1842	Phage shock protein A
LFT45_RS14775	COG0415	Belongs to the DNA photolyase family
LFT45_RS14795	COG1615	UPF0182 protein
LFT45_RS14820	COG2816	NAD+ diphosphatase activity
LFT45_RS14850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LFT45_RS14855	COG2011	ABC-type metal ion transport system permease component
LFT45_RS14860	COG1464	Belongs to the NlpA lipoprotein family
LFT45_RS14865	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LFT45_RS14870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_RS14875	COG0113	porphobilinogen synthase activity
LFT45_RS14885	COG0181	hydroxymethylbilane synthase activity
LFT45_RS14890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LFT45_RS14895	COG3253	May function as heme-dependent peroxidase
LFT45_RS14910	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LFT45_RS14915	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LFT45_RS14960	COG2154	pterin-4-alpha-carbinolamine dehydratase
LFT45_RS14965	COG2022	thiamine diphosphate biosynthetic process
LFT45_RS14975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LFT45_RS14975	COG2022	thiamine diphosphate biosynthetic process
LFT45_RS14980	COG0352	thiamine-phosphate diphosphorylase activity
LFT45_RS14990	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LFT45_RS14995	COG0513	Belongs to the DEAD box helicase family
LFT45_RS15000	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LFT45_RS15010	COG0006	proline dipeptidase activity
LFT45_RS15020	COG2239	Acts as a magnesium transporter
LFT45_RS15035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LFT45_RS15045	COG1595	DNA-templated transcription, initiation
LFT45_RS15070	COG1611	Belongs to the LOG family
LFT45_RS15075	COG1126	abc transporter atp-binding protein
LFT45_RS15080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LFT45_RS15085	COG0765	amino acid transport
LFT45_RS15090	COG0765	amino acid transport
LFT45_RS15095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LFT45_RS15100	COG2171	N-acyltransferase activity
LFT45_RS15115	COG3226	Transcriptional regulator
LFT45_RS15120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LFT45_RS15155	COG1217	gtp-binding protein TYPA
LFT45_RS15165	COG4172	Belongs to the ABC transporter superfamily
LFT45_RS15175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LFT45_RS15185	COG4166	transmembrane transport
LFT45_RS15190	COG0012	GTP binding
LFT45_RS15195	COG1322	Protein conserved in bacteria
LFT45_RS15200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LFT45_RS15210	COG1570	exodeoxyribonuclease VII activity
LFT45_RS15215	COG1722	exodeoxyribonuclease VII activity
LFT45_RS15220	COG2326	polyphosphate kinase activity
LFT45_RS15240	COG1174	glycine betaine transport
LFT45_RS15250	COG1162	GTPase activity
LFT45_RS15265	COG2971	BadF BadG BcrA BcrD
LFT45_RS15275	COG0583	DNA-binding transcription factor activity
LFT45_RS15280	COG2814	Major facilitator Superfamily
LFT45_RS15315	COG0598	Magnesium transport protein CorA
LFT45_RS15335	COG3415	Transposase
LFT45_RS15335	COG2801	Transposase and inactivated derivatives
LFT45_RS15360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LFT45_RS15365	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LFT45_RS15390	COG0519	Catalyzes the synthesis of GMP from XMP
LFT45_RS15390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LFT45_RS15410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LFT45_RS15415	COG0516	GMP reductase activity
LFT45_RS15425	COG1132	(ABC) transporter
LFT45_RS15440	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LFT45_RS15440	COG2755	lipolytic protein G-D-S-L family
LFT45_RS15445	COG0459	protein refolding
LFT45_RS15450	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LFT45_RS15465	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LFT45_RS15470	COG1472	Belongs to the glycosyl hydrolase 3 family
LFT45_RS15475	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LFT45_RS15480	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LFT45_RS15495	COG0802	atpase or kinase
LFT45_RS15500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LFT45_RS15510	COG1486	melibiose metabolic process
LFT45_RS15515	COG0438	transferase activity, transferring glycosyl groups
LFT45_RS15520	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LFT45_RS15545	COG0667	Aldo Keto reductase
LFT45_RS15565	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LFT45_RS15565	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LFT45_RS15570	COG0736	holo-[acyl-carrier-protein] synthase activity
LFT45_RS15580	COG1072	(Pantothenic acid kinase))
LFT45_RS15590	COG1970	mechanosensitive ion channel activity
LFT45_RS15595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LFT45_RS15600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LFT45_RS15605	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LFT45_RS15635	COG0455	bacterial-type flagellum organization
LFT45_RS15680	COG0489	protein tyrosine kinase activity
LFT45_RS15715	COG5002	protein histidine kinase activity
LFT45_RS15730	COG0745	RESPONSE REGULATOR receiver
LFT45_RS15735	COG0101	tRNA pseudouridine synthase activity
LFT45_RS15740	COG0203	ribosomal protein L17
LFT45_RS15745	COG0202	RNA polymerase activity
LFT45_RS15750	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LFT45_RS15755	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LFT45_RS15760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LFT45_RS15765	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LFT45_RS15770	COG3191	aminopeptidase activity
LFT45_RS15780	COG0563	adenylate kinase activity
LFT45_RS15790	COG0200	Binds to the 23S rRNA
LFT45_RS15795	COG1841	ribosomal large subunit assembly
LFT45_RS15800	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LFT45_RS15810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LFT45_RS15815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LFT45_RS15820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LFT45_RS15825	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LFT45_RS15830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LFT45_RS15835	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LFT45_RS15845	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LFT45_RS15850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LFT45_RS15855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LFT45_RS15860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LFT45_RS15865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LFT45_RS15870	COG0089	rRNA binding
LFT45_RS15875	COG0088	Forms part of the polypeptide exit tunnel
LFT45_RS15880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LFT45_RS15885	COG0051	transcription antitermination factor activity, RNA binding
LFT45_RS15895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LFT45_RS15900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LFT45_RS15905	COG0049	tRNA binding
LFT45_RS15910	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LFT45_RS15915	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LFT45_RS15920	COG0085	RNA polymerase activity
LFT45_RS15925	COG0183	Belongs to the thiolase family
LFT45_RS15930	COG0442	prolyl-tRNA aminoacylation
LFT45_RS15935	COG0222	ribosome binding
LFT45_RS15940	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LFT45_RS15955	COG0081	regulation of translation
LFT45_RS15960	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LFT45_RS15970	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LFT45_RS15980	COG0436	Aminotransferase
LFT45_RS15990	COG2801	Transposase and inactivated derivatives
LFT45_RS15995	COG2197	response regulator
LFT45_RS16040	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LFT45_RS16050	COG3485	protocatechuate 3,4-dioxygenase
LFT45_RS16060	COG0745	RESPONSE REGULATOR receiver
LFT45_RS16065	COG0456	acetyltransferase
LFT45_RS16070	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LFT45_RS16090	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LFT45_RS16095	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LFT45_RS16120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LFT45_RS16130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LFT45_RS16140	COG2030	dehydratase
LFT45_RS16170	COG4989	oxidoreductase activity
LFT45_RS16175	COG0366	Alpha amylase catalytic
LFT45_RS16180	COG0395	ABC-type sugar transport system, permease component
LFT45_RS16185	COG1175	transmembrane transport
LFT45_RS16195	COG1940	carbohydrate kinase activity
LFT45_RS16205	COG0702	epimerase
LFT45_RS16245	COG0754	glutathionylspermidine amidase activity
LFT45_RS16305	COG5650	phosphatidylinositol metabolic process
LFT45_RS16320	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LFT45_RS16325	COG0346	lactoylglutathione lyase activity
LFT45_RS16345	COG2826	transposase and inactivated derivatives, IS30 family
LFT45_RS16350	COG0318	PFAM AMP-dependent synthetase and ligase
LFT45_RS16360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LFT45_RS16365	COG1388	LysM domain
LFT45_RS16365	COG3942	CHAP domain
LFT45_RS16370	COG2801	Transposase and inactivated derivatives
LFT45_RS16370	COG3415	Transposase
LFT45_RS16385	COG1666	GTP binding
LFT45_RS16395	COG0501	Belongs to the peptidase M48B family
LFT45_RS16420	COG0531	amino acid
LFT45_RS16470	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_RS16490	COG0574	Belongs to the PEP-utilizing enzyme family
LFT45_RS16490	COG3848	Pyruvate phosphate dikinase
LFT45_RS16505	COG2186	Transcriptional regulator
LFT45_RS16540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LFT45_RS16540	COG1648	precorrin-2 dehydrogenase activity
LFT45_RS16555	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LFT45_RS16565	COG1690	Belongs to the RtcB family
LFT45_RS16585	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LFT45_RS16595	COG2860	membrane
LFT45_RS16610	COG0142	geranyltranstransferase activity
LFT45_RS16620	COG2226	methyltransferase
LFT45_RS16625	COG1169	isochorismate synthase
LFT45_RS16630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LFT45_RS16635	COG0765	amino acid transport
LFT45_RS16650	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LFT45_RS16655	COG2801	Transposase and inactivated derivatives
LFT45_RS16670	COG4948	Mandelate Racemase Muconate Lactonizing
LFT45_RS16675	COG4585	Histidine kinase
LFT45_RS16685	COG5002	protein histidine kinase activity
LFT45_RS16725	COG0436	Aminotransferase
LFT45_RS16755	COG4172	Belongs to the ABC transporter superfamily
LFT45_RS16760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LFT45_RS16765	COG0601	transmembrane transport
LFT45_RS16770	COG4166	transmembrane transport
LFT45_RS16815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LFT45_RS16820	COG0569	domain protein
LFT45_RS16855	COG1472	Belongs to the glycosyl hydrolase 3 family
LFT45_RS16930	COG0531	amino acid
LFT45_RS16935	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS16945	COG0765	amino acid transport
LFT45_RS16950	COG0765	amino acid transport
LFT45_RS17000	COG2826	transposase and inactivated derivatives, IS30 family
LFT45_RS17005	COG0477	Major facilitator Superfamily
LFT45_RS17035	COG1196	nuclear chromosome segregation
LFT45_RS17035	COG0741	lytic transglycosylase activity
LFT45_RS17035	COG0739	heme binding
LFT45_RS17040	COG2124	cytochrome p450
LFT45_RS17040	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LFT45_RS17070	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LFT45_RS17080	COG0443	Heat shock 70 kDa protein
LFT45_RS17140	COG4152	abc transporter atp-binding protein
LFT45_RS17150	COG3655	Transcriptional regulator
LFT45_RS17160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LFT45_RS17170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LFT45_RS17175	COG1404	Belongs to the peptidase S8 family
LFT45_RS17215	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LFT45_RS17215	COG2755	lipolytic protein G-D-S-L family
LFT45_RS17260	COG0508	dehydrogenase complex catalyzes the overall conversion of
LFT45_RS17285	COG0489	protein tyrosine kinase activity
LFT45_RS17300	COG0297	glycogen (starch) synthase activity
LFT45_RS17305	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LFT45_RS17310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LFT45_RS17320	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LFT45_RS17335	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LFT45_RS17345	COG1024	Enoyl-CoA hydratase
LFT45_RS17350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LFT45_RS17355	COG2151	metal-sulfur cluster biosynthetic enzyme
LFT45_RS17360	COG3396	Phenylacetate-CoA oxygenase
LFT45_RS17365	COG3460	Phenylacetate-CoA oxygenase
LFT45_RS17370	COG3396	Phenylacetate-CoA oxygenase
LFT45_RS17400	COG3979	chitinase
LFT45_RS17465	COG0277	FAD linked oxidase domain protein
LFT45_RS17475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LFT45_RS17490	COG2217	Heavy metal translocating P-type atpase
LFT45_RS17505	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS17530	COG2755	lipolytic protein G-D-S-L family
LFT45_RS17560	COG1011	Hydrolase
LFT45_RS17590	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LFT45_RS17600	COG1064	alcohol dehydrogenase
LFT45_RS17625	COG0492	ferredoxin-NADP+ reductase activity
LFT45_RS17630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LFT45_RS17635	COG0492	ferredoxin-NADP+ reductase activity
LFT45_RS17645	COG0640	Transcriptional regulator
LFT45_RS17665	COG0601	transmembrane transport
LFT45_RS17670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LFT45_RS17675	COG0444	Belongs to the ABC transporter superfamily
LFT45_RS17680	COG4608	Belongs to the ABC transporter superfamily
LFT45_RS17690	COG1621	beta-fructofuranosidase activity
LFT45_RS17755	COG1609	Transcriptional regulator
LFT45_RS17760	COG2814	Major facilitator Superfamily
LFT45_RS17820	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LFT45_RS17880	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LFT45_RS17890	COG1063	alcohol dehydrogenase
LFT45_RS17930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LFT45_RS17935	COG1316	TRANSCRIPTIONal
LFT45_RS17950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LFT45_RS17985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LFT45_RS18020	COG5002	protein histidine kinase activity
LFT45_RS18045	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LFT45_RS18050	COG0857	belongs to the CobB CobQ family
LFT45_RS18050	COG0280	phosphate acetyltransferase
LFT45_RS18065	COG2050	protein possibly involved in aromatic compounds catabolism
LFT45_RS18075	COG2132	Multicopper oxidase
LFT45_RS18095	COG2801	Transposase and inactivated derivatives
LFT45_RS18105	COG2030	dehydratase
LFT45_RS18105	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_RS18110	COG2050	protein possibly involved in aromatic compounds catabolism
LFT45_RS18115	COG0390	transport system, permease component
LFT45_RS18150	COG1250	3-hydroxyacyl-CoA dehydrogenase
LFT45_RS18155	COG1024	Enoyl-CoA hydratase
LFT45_RS18160	COG0183	Belongs to the thiolase family
LFT45_RS18205	COG0488	(ABC) transporter
LFT45_RS18210	COG1266	CAAX protease self-immunity
LFT45_RS18220	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LFT45_RS18250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LFT45_RS18260	COG0785	Cytochrome C biogenesis protein
LFT45_RS18265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LFT45_RS18270	COG0406	alpha-ribazole phosphatase activity
LFT45_RS18275	COG2353	YceI-like domain
LFT45_RS18285	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LFT45_RS18310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LFT45_RS18315	COG2814	Major facilitator Superfamily
LFT45_RS18320	COG1070	Carbohydrate kinase
LFT45_RS18325	COG3347	Dehydrogenase
LFT45_RS18325	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS18330	COG4952	isomerase
LFT45_RS18335	COG3254	rhamnose metabolic process
LFT45_RS18360	COG0395	ABC-type sugar transport system, permease component
LFT45_RS18365	COG1175	transmembrane transport
LFT45_RS18380	COG4948	Mandelate Racemase Muconate Lactonizing
LFT45_RS18385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LFT45_RS18395	COG0673	inositol 2-dehydrogenase activity
LFT45_RS18400	COG1609	Transcriptional regulator
LFT45_RS18410	COG2814	Major facilitator Superfamily
LFT45_RS18420	COG2186	Transcriptional regulator
LFT45_RS18430	COG0640	Transcriptional regulator
LFT45_RS18435	COG0123	including yeast histone deacetylase and acetoin utilization protein
LFT45_RS18440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LFT45_RS18445	COG0569	domain protein
LFT45_RS18450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LFT45_RS18455	COG0248	Ppx GppA phosphatase
LFT45_RS18465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LFT45_RS18465	COG1754	DNA topoisomerase type I activity
LFT45_RS18480	COG2890	protein-(glutamine-N5) methyltransferase activity
LFT45_RS18500	COG1054	Belongs to the UPF0176 family
LFT45_RS18510	COG1111	helicase
LFT45_RS18510	COG1205	dead DEAH box helicase
LFT45_RS18560	COG1051	belongs to the nudix hydrolase family
LFT45_RS18575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LFT45_RS18590	COG0395	ABC-type sugar transport system, permease component
LFT45_RS18595	COG1349	DNA-binding transcription factor activity
LFT45_RS18610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LFT45_RS18635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LFT45_RS18640	COG1408	metallophosphoesterase
LFT45_RS18645	COG1132	(ABC) transporter
LFT45_RS18650	COG1132	(ABC) transporter
LFT45_RS18675	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LFT45_RS18680	COG0151	Belongs to the GarS family
LFT45_RS18700	COG1301	dicarboxylic acid transport
LFT45_RS18715	COG4221	oxidoreductase activity
LFT45_RS18725	COG1953	Uracil, thiamine, allantoin
LFT45_RS18730	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LFT45_RS18750	COG0667	Aldo Keto reductase
LFT45_RS18755	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LFT45_RS18765	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LFT45_RS18765	COG3608	succinylglutamate desuccinylase aspartoacylase
LFT45_RS18770	COG2252	PERMEase
LFT45_RS18775	COG0590	tRNA wobble adenosine to inosine editing
LFT45_RS18800	COG2233	PERMEase
LFT45_RS18805	COG2801	Transposase and inactivated derivatives
LFT45_RS18805	COG3415	Transposase
LFT45_RS18810	COG1414	Transcriptional regulator
LFT45_RS18820	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LFT45_RS18830	COG3257	ureidoglycine aminohydrolase activity
LFT45_RS18840	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS18855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LFT45_RS18865	COG3387	PFAM Glycoside hydrolase 15-related
LFT45_RS18895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LFT45_RS18905	COG0484	heat shock protein binding
LFT45_RS18940	COG3540	Alkaline phosphatase
LFT45_RS18945	COG4948	Mandelate Racemase Muconate Lactonizing
LFT45_RS18950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LFT45_RS18955	COG0800	Aldolase
LFT45_RS18960	COG4948	Mandelate Racemase Muconate Lactonizing
LFT45_RS18965	COG0395	ABC-type sugar transport system, permease component
LFT45_RS18970	COG1175	transmembrane transport
LFT45_RS18985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LFT45_RS19025	COG1072	(Pantothenic acid kinase))
LFT45_RS19040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_RS19045	COG2267	carboxylic ester hydrolase activity
LFT45_RS19060	COG0598	Magnesium transport protein CorA
LFT45_RS19085	COG2186	Transcriptional regulator
LFT45_RS19095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LFT45_RS19130	COG1132	(ABC) transporter
LFT45_RS19185	COG0671	phosphoesterase, PA-phosphatase related
LFT45_RS19210	COG4336	lyase activity
LFT45_RS19225	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LFT45_RS19230	COG1984	allophanate hydrolase subunit 2
LFT45_RS19235	COG4770	biotin carboxylase activity
LFT45_RS19245	COG0473	3-isopropylmalate dehydrogenase activity
LFT45_RS19255	COG3842	ATPase activity
LFT45_RS19260	COG4149	molybdate abc transporter
LFT45_RS19270	COG1802	Transcriptional regulator
LFT45_RS19290	COG1053	succinate dehydrogenase
LFT45_RS19315	COG0477	Major facilitator Superfamily
LFT45_RS19325	COG1414	Transcriptional regulator
LFT45_RS19330	COG0477	Major facilitator Superfamily
LFT45_RS19335	COG0583	DNA-binding transcription factor activity
LFT45_RS19345	COG1063	alcohol dehydrogenase
LFT45_RS19350	COG1053	succinate dehydrogenase
LFT45_RS19355	COG1609	Transcriptional regulator
LFT45_RS19360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LFT45_RS19365	COG4948	Mandelate Racemase Muconate Lactonizing
LFT45_RS19370	COG0246	Mannitol dehydrogenase
LFT45_RS19375	COG1063	alcohol dehydrogenase
LFT45_RS19380	COG0477	Major facilitator Superfamily
LFT45_RS19400	COG5001	Diguanylate cyclase
LFT45_RS19410	COG1737	Transcriptional regulator
LFT45_RS19420	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_RS19440	COG3265	gluconokinase activity
LFT45_RS19445	COG1063	alcohol dehydrogenase
LFT45_RS19450	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS19460	COG4221	oxidoreductase activity
LFT45_RS19465	COG0477	Major facilitator Superfamily
LFT45_RS19475	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LFT45_RS19480	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LFT45_RS19485	COG0583	DNA-binding transcription factor activity
LFT45_RS19500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LFT45_RS19505	COG0436	Aminotransferase
LFT45_RS19520	COG0747	negative chemotaxis
LFT45_RS19525	COG0601	transmembrane transport
LFT45_RS19530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LFT45_RS19540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_RS19565	COG3585	molybdate ion transport
LFT45_RS19610	COG0395	ABC-type sugar transport system, permease component
LFT45_RS19615	COG1175	transmembrane transport
LFT45_RS19625	COG1609	Transcriptional regulator
LFT45_RS19635	COG2154	pterin-4-alpha-carbinolamine dehydratase
LFT45_RS19640	COG0702	epimerase
LFT45_RS19645	COG2267	carboxylic ester hydrolase activity
LFT45_RS19695	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LFT45_RS19720	COG0667	Aldo Keto reductase
LFT45_RS19745	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LFT45_RS19785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LFT45_RS19790	COG0318	PFAM AMP-dependent synthetase and ligase
LFT45_RS19795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LFT45_RS19815	COG0583	DNA-binding transcription factor activity
LFT45_RS19825	COG0833	amino acid
LFT45_RS19900	COG3942	CHAP domain
LFT45_RS19900	COG1388	LysM domain
LFT45_RS19920	COG1609	Transcriptional regulator
LFT45_RS19930	COG4209	transmembrane transport
LFT45_RS19935	COG0395	ABC-type sugar transport system, permease component
LFT45_RS19940	COG2182	Extracellular solute-binding protein
LFT45_RS19950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LFT45_RS19955	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LFT45_RS19960	COG1940	carbohydrate kinase activity
LFT45_RS19960	COG1846	Transcriptional regulator
LFT45_RS19970	COG1653	transport
LFT45_RS19975	COG1175	transmembrane transport
LFT45_RS19980	COG0395	ABC-type sugar transport system, permease component
LFT45_RS20010	COG0384	phenazine biosynthesis protein PhzF
LFT45_RS20040	COG1132	(ABC) transporter
LFT45_RS20055	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LFT45_RS20065	COG0640	Transcriptional regulator
LFT45_RS20075	COG3622	Belongs to the hyi family
LFT45_RS20080	COG2084	Dehydrogenase
LFT45_RS20085	COG3960	tartronate-semialdehyde synthase activity
LFT45_RS20090	COG1929	Belongs to the glycerate kinase type-1 family
LFT45_RS20095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LFT45_RS20115	COG1760	l-serine dehydratase
LFT45_RS20140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LFT45_RS20145	COG1802	Transcriptional regulator
LFT45_RS20170	COG0179	Fumarylacetoacetate (FAA) hydrolase
LFT45_RS20185	COG3250	beta-galactosidase activity
LFT45_RS20190	COG0657	acetylesterase activity
LFT45_RS20225	COG1309	transcriptional regulator
LFT45_RS20235	COG2199	diguanylate cyclase activity
LFT45_RS20235	COG2200	EAL domain
LFT45_RS20240	COG3250	beta-galactosidase activity
LFT45_RS20270	COG1819	glycosyl
LFT45_RS20275	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LFT45_RS20290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LFT45_RS20295	COG0438	transferase activity, transferring glycosyl groups
LFT45_RS20305	COG0477	Major facilitator Superfamily
LFT45_RS20335	COG3404	Formiminotransferase-cyclodeaminase
LFT45_RS20360	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LFT45_RS20400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LFT45_RS20415	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_RS20420	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LFT45_RS20430	COG5002	protein histidine kinase activity
LFT45_RS20440	COG0745	RESPONSE REGULATOR receiver
LFT45_RS20445	COG1215	transferase activity, transferring glycosyl groups
LFT45_RS20450	COG1366	Belongs to the anti-sigma-factor antagonist family
LFT45_RS20465	COG2205	protein histidine kinase activity
LFT45_RS20475	COG2351	hydroxyisourate hydrolase activity
LFT45_RS20495	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LFT45_RS20515	COG0542	response to heat
LFT45_RS20540	COG3304	Inner membrane component domain
LFT45_RS20550	COG0135	phosphoribosylanthranilate isomerase activity
LFT45_RS20560	COG1528	Iron-storage protein
LFT45_RS20585	COG1113	amino acid transport
LFT45_RS20595	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LFT45_RS20600	COG2146	nitrite reductase [NAD(P)H] activity
LFT45_RS20620	COG1473	amidohydrolase
LFT45_RS20625	COG0477	Major facilitator Superfamily
LFT45_RS20630	COG2807	transmembrane transport
LFT45_RS20640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LFT45_RS20645	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LFT45_RS20660	COG1595	DNA-templated transcription, initiation
LFT45_RS20675	COG1621	beta-fructofuranosidase activity
LFT45_RS20680	COG0395	ABC-type sugar transport system, permease component
LFT45_RS20685	COG1175	transmembrane transport
LFT45_RS20695	COG1609	Transcriptional regulator
LFT45_RS20705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LFT45_RS20720	COG2186	Transcriptional regulator
LFT45_RS20725	COG0477	Major facilitator Superfamily
LFT45_RS20750	COG0659	secondary active sulfate transmembrane transporter activity
LFT45_RS20755	COG2084	Dehydrogenase
LFT45_RS20760	COG1082	Xylose isomerase domain protein TIM barrel
LFT45_RS20765	COG0149	triose-phosphate isomerase activity
LFT45_RS20770	COG0698	ribose 5-phosphate isomerase
LFT45_RS20775	COG2376	Dihydroxyacetone kinase
LFT45_RS20785	COG2186	Transcriptional regulator
LFT45_RS20810	COG3135	benzoate transporter
LFT45_RS20830	COG4941	Belongs to the sigma-70 factor family
LFT45_RS20840	COG0563	adenylate kinase activity
LFT45_RS20850	COG3290	protein histidine kinase activity
LFT45_RS20870	COG0589	response to stress
LFT45_RS20875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LFT45_RS20880	COG0574	Belongs to the PEP-utilizing enzyme family
LFT45_RS20880	COG3848	Pyruvate phosphate dikinase
LFT45_RS20885	COG0789	Transcriptional regulator
LFT45_RS20890	COG0484	heat shock protein binding
LFT45_RS20895	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LFT45_RS20900	COG0443	Heat shock 70 kDa protein
LFT45_RS20920	COG2409	Drug exporters of the RND superfamily
LFT45_RS20935	COG1280	lysine exporter protein (LysE YggA)
LFT45_RS20950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LFT45_RS20960	COG2200	EAL domain
LFT45_RS20960	COG2199	diguanylate cyclase activity
LFT45_RS20960	COG3287	FIST C domain
LFT45_RS20970	COG2986	histidine ammonia-lyase
LFT45_RS21000	COG0318	PFAM AMP-dependent synthetase and ligase
LFT45_RS21005	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LFT45_RS21010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LFT45_RS21030	COG1122	ATPase activity
LFT45_RS21035	COG4721	ABC-type cobalt transport system, permease component
LFT45_RS21040	COG4702	Belongs to the UPF0303 family
LFT45_RS21055	COG1320	monovalent cation:proton antiporter activity
LFT45_RS21060	COG2212	antiporter activity
LFT45_RS21070	COG0651	ATP synthesis coupled electron transport
LFT45_RS21075	COG1006	Multisubunit Na H antiporter MnhC subunit
LFT45_RS21080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LFT45_RS21080	COG2111	Na H antiporter
LFT45_RS21095	COG0475	glutathione-regulated potassium exporter activity
LFT45_RS21105	COG0717	Belongs to the dCTP deaminase family
LFT45_RS21125	COG0583	DNA-binding transcription factor activity
LFT45_RS21135	COG1012	belongs to the aldehyde dehydrogenase family
LFT45_RS21140	COG0531	amino acid
LFT45_RS21150	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LFT45_RS21165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LFT45_RS21170	COG0433	COG0433 Predicted ATPase
LFT45_RS21190	COG3336	cytochrome c oxidase
LFT45_RS21195	COG0776	regulation of translation
LFT45_RS21245	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LFT45_RS21250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LFT45_RS21255	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LFT45_RS21260	COG1017	nitric oxide dioxygenase activity
LFT45_RS21260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LFT45_RS21300	COG1120	ATPase activity
LFT45_RS21305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LFT45_RS21310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LFT45_RS21365	COG3012	SEC-C Motif Domain Protein
LFT45_RS21375	COG0667	Aldo Keto reductase
LFT45_RS21390	COG1028	Short-chain dehydrogenase reductase Sdr
LFT45_RS21405	COG3959	Transketolase, thiamine diphosphate binding domain
LFT45_RS21410	COG3958	Transketolase
LFT45_RS21430	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LFT45_RS21435	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LFT45_RS21475	COG2186	Transcriptional regulator
LFT45_RS21500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LFT45_RS21500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LFT45_RS21510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LFT45_RS21525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LFT45_RS21540	COG1522	sequence-specific DNA binding
LFT45_RS21545	COG1280	lysine exporter protein (LysE YggA)
LFT45_RS21565	COG0281	malic enzyme
LFT45_RS21580	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LFT45_RS21585	COG0477	Major facilitator Superfamily
LFT45_RS21590	COG0477	Major facilitator Superfamily
LFT45_RS21595	COG2814	Major facilitator Superfamily
LFT45_RS21605	COG1609	Transcriptional regulator
LFT45_RS21615	COG1175	transmembrane transport
LFT45_RS21620	COG0395	ABC-type sugar transport system, permease component
LFT45_RS21625	COG3250	beta-galactosidase activity
LFT45_RS21630	COG1733	regulation of RNA biosynthetic process
LFT45_RS21635	COG0702	epimerase
LFT45_RS21640	COG0246	Mannitol dehydrogenase
LFT45_RS21645	COG2213	PTS system mannitol-specific
LFT45_RS21645	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LFT45_RS21655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LFT45_RS21690	COG0686	Belongs to the AlaDH PNT family
LFT45_RS21695	COG0673	inositol 2-dehydrogenase activity
LFT45_RS21705	COG0431	NADPH-dependent FMN reductase
LFT45_RS21720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LFT45_RS21740	COG0508	dehydrogenase complex catalyzes the overall conversion of
LFT45_RS21745	COG0022	dehydrogenase e1 component
LFT45_RS21755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LFT45_RS21760	COG1950	PFAM Membrane protein of
LFT45_RS21775	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LFT45_RS21780	COG0406	alpha-ribazole phosphatase activity
LFT45_RS21790	COG1607	acyl-coa hydrolase
LFT45_RS21815	COG0243	molybdopterin cofactor binding
LFT45_RS21840	COG0667	Aldo Keto reductase
LFT45_RS21860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LFT45_RS21870	COG0583	DNA-binding transcription factor activity
LFT45_RS21905	COG1414	Transcriptional regulator
LFT45_RS21910	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LFT45_RS21920	COG0183	Belongs to the thiolase family
LFT45_RS21925	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LFT45_RS21935	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LFT45_RS21940	COG3485	protocatechuate 3,4-dioxygenase
LFT45_RS21945	COG3485	protocatechuate 3,4-dioxygenase
LFT45_RS21950	COG1082	Xylose isomerase domain protein TIM barrel
LFT45_RS21950	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LFT45_RS21955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LFT45_RS21960	COG1414	Transcriptional regulator
LFT45_RS21970	COG1793	dna ligase
LFT45_RS21985	COG0366	Alpha amylase catalytic
LFT45_RS21995	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LFT45_RS22015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LFT45_RS22030	COG1937	Protein conserved in bacteria
LFT45_RS22055	COG0697	spore germination
LFT45_RS22075	COG0534	Mate efflux family protein
LFT45_RS22080	COG2259	Doxx family
LFT45_RS22095	COG0305	Participates in initiation and elongation during chromosome replication
LFT45_RS22125	COG0359	binds to the 23S rRNA
LFT45_RS22130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LFT45_RS22140	COG0360	Binds together with S18 to 16S ribosomal RNA
LFT45_RS22145	COG1742	UPF0060 membrane protein
LFT45_RS22150	COG1113	amino acid transport
LFT45_RS22155	COG1362	aminopeptidase activity
LFT45_RS22165	COG2197	response regulator
LFT45_RS22170	COG4585	Histidine kinase
LFT45_RS22180	COG1131	(ABC) transporter
LFT45_RS22190	COG0738	Major facilitator superfamily
LFT45_RS22220	COG0406	alpha-ribazole phosphatase activity
LFT45_RS22225	COG0617	tRNA 3'-terminal CCA addition
LFT45_RS22245	COG0492	ferredoxin-NADP+ reductase activity
LFT45_RS22250	COG3118	belongs to the thioredoxin family
LFT45_RS22260	COG1192	Involved in chromosome partitioning
LFT45_RS22265	COG0357	Ribosomal RNA small subunit methyltransferase G
LFT45_RS22275	COG0706	membrane insertase activity
LFT45_RS22280	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LFT45_RS22285	COG0594	ribonuclease P activity
LFT45_RS22290	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LFT45_RS22325	COG2354	Protein conserved in bacteria
LFT45_RS22345	COG0785	Cytochrome C biogenesis protein
LFT45_RS22350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LFT45_RS22360	COG2124	cytochrome p450
LFT45_RS22370	COG2132	Multicopper oxidase
LFT45_RS22395	COG1321	iron dependent repressor
LFT45_RS22435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LFT45_RS22440	COG0492	ferredoxin-NADP+ reductase activity
LFT45_RS22450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LFT45_RS22455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LFT45_RS22565	COG1475	DNA binding
LFT45_RS22605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LFT45_RS22635	COG1793	dna ligase
LFT45_RS22640	COG2135	peptidase activity
LFT45_RS22685	COG1192	Involved in chromosome partitioning
LFT45_RS22765	COG0741	lytic transglycosylase activity
LFT45_RS22830	COG0659	secondary active sulfate transmembrane transporter activity
LFT45_RS22870	COG3336	cytochrome c oxidase
LFT45_RS22875	COG0640	Transcriptional regulator
LFT45_RS22915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LFT45_RS22920	COG2017	converts alpha-aldose to the beta-anomer
LFT45_RS22930	COG0395	ABC-type sugar transport system, permease component
LFT45_RS22935	COG1175	transmembrane transport
LFT45_RS22950	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LFT45_RS22960	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LFT45_RS23030	COG1475	DNA binding
LFT45_RS23090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LFT45_RS23130	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LFT45_RS23140	COG1192	Involved in chromosome partitioning