locus-tag	class	description
AFL94_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFL94_RS00010	COG0592	DNA-directed DNA polymerase activity
AFL94_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AFL94_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AFL94_RS00025	COG0187	DNA topoisomerase II activity
AFL94_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AFL94_RS00035	COG3266	domain, Protein
AFL94_RS00060	COG0385	Bile acid
AFL94_RS00075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AFL94_RS00090	COG0583	DNA-binding transcription factor activity
AFL94_RS00095	COG2076	Multidrug Resistance protein
AFL94_RS00105	COG3764	Sortase (surface protein transpeptidase)
AFL94_RS00115	COG0515	serine threonine protein kinase
AFL94_RS00115	COG2815	serine threonine protein kinase
AFL94_RS00120	COG0515	serine threonine protein kinase
AFL94_RS00140	COG1716	ATPase activity
AFL94_RS00165	COG1609	Transcriptional regulator
AFL94_RS00170	COG1957	nucleoside hydrolase
AFL94_RS00175	COG0412	Dienelactone hydrolase
AFL94_RS00190	COG1024	Enoyl-CoA hydratase
AFL94_RS00200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFL94_RS00205	COG0561	phosphatase activity
AFL94_RS00225	COG0477	Major facilitator Superfamily
AFL94_RS00230	COG2233	PERMEase
AFL94_RS00235	COG0351	phosphomethylpyrimidine kinase
AFL94_RS00235	COG0352	thiamine-phosphate diphosphorylase activity
AFL94_RS00235	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AFL94_RS00240	COG0352	thiamine-phosphate diphosphorylase activity
AFL94_RS00245	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AFL94_RS00260	COG1012	belongs to the aldehyde dehydrogenase family
AFL94_RS00265	COG0833	amino acid
AFL94_RS00270	COG0033	Phosphoglucomutase
AFL94_RS00285	COG3655	Transcriptional regulator
AFL94_RS00290	COG3104	oligopeptide transport
AFL94_RS00295	COG0154	amidase activity
AFL94_RS00315	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AFL94_RS00320	COG0561	phosphatase activity
AFL94_RS00345	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AFL94_RS00360	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AFL94_RS00365	COG2027	D-alanyl-D-alanine carboxypeptidase
AFL94_RS00375	COG0037	tRNA processing
AFL94_RS00385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFL94_RS00390	COG0302	gtp cyclohydrolase
AFL94_RS00400	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AFL94_RS00425	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AFL94_RS00450	COG1476	TRANSCRIPTIONal
AFL94_RS00480	COG3590	peptidase
AFL94_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AFL94_RS00515	COG4977	sequence-specific DNA binding
AFL94_RS00525	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AFL94_RS00535	COG1194	a g-specific adenine glycosylase
AFL94_RS00545	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AFL94_RS00550	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AFL94_RS00560	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AFL94_RS00575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AFL94_RS00590	COG0306	phosphate transporter
AFL94_RS00640	COG0488	(ABC) transporter
AFL94_RS00645	COG2226	methyltransferase
AFL94_RS00680	COG0596	Alpha beta hydrolase
AFL94_RS00690	COG0824	Thioesterase
AFL94_RS00705	COG1937	Protein conserved in bacteria
AFL94_RS00710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFL94_RS00725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFL94_RS00745	COG0277	FAD linked oxidase domain protein
AFL94_RS00845	COG4122	O-methyltransferase activity
AFL94_RS00870	COG2252	PERMEase
AFL94_RS00920	COG1024	Enoyl-CoA hydratase
AFL94_RS00935	COG1960	acyl-CoA dehydrogenase activity
AFL94_RS00970	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AFL94_RS00985	COG1129	ABC transporter
AFL94_RS00985	COG0842	Transport permease protein
AFL94_RS01000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFL94_RS01000	COG0357	Ribosomal RNA small subunit methyltransferase G
AFL94_RS01020	COG0515	serine threonine protein kinase
AFL94_RS01075	COG0745	RESPONSE REGULATOR receiver
AFL94_RS01080	COG5002	protein histidine kinase activity
AFL94_RS01090	COG1522	sequence-specific DNA binding
AFL94_RS01100	COG1113	amino acid transport
AFL94_RS01120	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AFL94_RS01125	COG0004	ammonium transporteR
AFL94_RS01130	COG0347	Belongs to the P(II) protein family
AFL94_RS01145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFL94_RS01155	COG0583	DNA-binding transcription factor activity
AFL94_RS01165	COG0697	spore germination
AFL94_RS01180	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AFL94_RS01190	COG0028	Belongs to the TPP enzyme family
AFL94_RS01195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFL94_RS01215	COG0726	polysaccharide deacetylase
AFL94_RS01230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFL94_RS01235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AFL94_RS01235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFL94_RS01235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AFL94_RS01245	COG1349	DNA-binding transcription factor activity
AFL94_RS01255	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFL94_RS01260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFL94_RS01265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFL94_RS01270	COG1832	CoA-binding protein
AFL94_RS01275	COG2873	o-acetylhomoserine
AFL94_RS01280	COG0406	alpha-ribazole phosphatase activity
AFL94_RS01290	COG2169	Transcriptional regulator
AFL94_RS01290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFL94_RS01295	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AFL94_RS01305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AFL94_RS01310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFL94_RS01345	COG0405	Gamma-glutamyltransferase
AFL94_RS01365	COG0702	epimerase
AFL94_RS01375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AFL94_RS01380	COG2011	ABC-type metal ion transport system permease component
AFL94_RS01385	COG1464	Belongs to the NlpA lipoprotein family
AFL94_RS01390	COG1960	acyl-CoA dehydrogenase activity
AFL94_RS01400	COG1832	CoA-binding protein
AFL94_RS01405	COG2315	Protein conserved in bacteria
AFL94_RS01420	COG0737	Belongs to the 5'-nucleotidase family
AFL94_RS01445	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_RS01450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFL94_RS01460	COG2824	Alkylphosphonate utilization operon protein PhnA
AFL94_RS01475	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFL94_RS01480	COG0047	phosphoribosylformylglycinamidine synthase activity
AFL94_RS01485	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFL94_RS01490	COG3012	SEC-C Motif Domain Protein
AFL94_RS01500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AFL94_RS01520	COG2318	DinB family
AFL94_RS01525	COG2851	Citrate transporter
AFL94_RS01530	COG3290	protein histidine kinase activity
AFL94_RS01535	COG4565	transcriptional regulatory protein
AFL94_RS01565	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AFL94_RS01575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFL94_RS01595	COG0745	RESPONSE REGULATOR receiver
AFL94_RS01630	COG0406	alpha-ribazole phosphatase activity
AFL94_RS01640	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AFL94_RS01650	COG2814	Major facilitator Superfamily
AFL94_RS01660	COG0523	cobalamin synthesis protein
AFL94_RS01665	COG1476	TRANSCRIPTIONal
AFL94_RS01675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFL94_RS01680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AFL94_RS01685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AFL94_RS01695	COG0531	amino acid
AFL94_RS01710	COG1414	Transcriptional regulator
AFL94_RS01745	COG0542	response to heat
AFL94_RS01750	COG2197	response regulator
AFL94_RS01755	COG4585	Histidine kinase
AFL94_RS01760	COG0778	Nitroreductase
AFL94_RS01790	COG1472	Belongs to the glycosyl hydrolase 3 family
AFL94_RS01805	COG0351	phosphomethylpyrimidine kinase
AFL94_RS01825	COG4133	protoheme IX ABC transporter activity
AFL94_RS01835	COG0343	queuine tRNA-ribosyltransferase activity
AFL94_RS01850	COG2814	Major facilitator Superfamily
AFL94_RS01865	COG0564	pseudouridine synthase activity
AFL94_RS01870	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFL94_RS01875	COG1201	RNA secondary structure unwinding
AFL94_RS01880	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AFL94_RS01885	COG0671	phosphoesterase, PA-phosphatase related
AFL94_RS01890	COG1414	Transcriptional regulator
AFL94_RS01900	COG0786	glutamate:sodium symporter activity
AFL94_RS01905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFL94_RS01920	COG1131	(ABC) transporter
AFL94_RS01945	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFL94_RS01960	COG3485	protocatechuate 3,4-dioxygenase
AFL94_RS01965	COG3485	protocatechuate 3,4-dioxygenase
AFL94_RS01975	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
AFL94_RS01985	COG2814	Major facilitator Superfamily
AFL94_RS01990	COG0183	Belongs to the thiolase family
AFL94_RS02000	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AFL94_RS02005	COG1414	Transcriptional regulator
AFL94_RS02030	COG0584	glycerophosphoryl diester phosphodiesterase
AFL94_RS02035	COG0315	cyclic pyranopterin monophosphate synthase activity
AFL94_RS02035	COG0521	Mo-molybdopterin cofactor biosynthetic process
AFL94_RS02040	COG0315	cyclic pyranopterin monophosphate synthase activity
AFL94_RS02070	COG2318	DinB family
AFL94_RS02080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AFL94_RS02105	COG0746	molybdenum cofactor guanylyltransferase activity
AFL94_RS02130	COG1140	nitrate reductase beta subunit
AFL94_RS02175	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AFL94_RS02180	COG2205	protein histidine kinase activity
AFL94_RS02185	COG0745	RESPONSE REGULATOR receiver
AFL94_RS02205	COG2274	protein secretion by the type I secretion system
AFL94_RS02215	COG1511	domain protein
AFL94_RS02245	COG2723	6-phospho-beta-galactosidase activity
AFL94_RS02270	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AFL94_RS02275	COG2814	Major facilitator Superfamily
AFL94_RS02285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AFL94_RS02285	COG0596	Alpha beta hydrolase
AFL94_RS02290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFL94_RS02290	COG1017	nitric oxide dioxygenase activity
AFL94_RS02295	COG1959	2 iron, 2 sulfur cluster binding
AFL94_RS02310	COG0514	ATP-dependent DNA helicase (RecQ)
AFL94_RS02325	COG1505	serine-type exopeptidase activity
AFL94_RS02340	COG0604	alcohol dehydrogenase
AFL94_RS02345	COG1966	Carbon starvation protein
AFL94_RS02360	COG0656	L-ascorbic acid biosynthetic process
AFL94_RS02390	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AFL94_RS02405	COG0588	phosphoglycerate mutase activity
AFL94_RS02420	COG5002	protein histidine kinase activity
AFL94_RS02435	COG1329	Transcriptional regulator
AFL94_RS02440	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AFL94_RS02440	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AFL94_RS02445	COG0215	cysteine-tRNA ligase activity
AFL94_RS02450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFL94_RS02470	COG0277	FAD linked oxidase domain protein
AFL94_RS02510	COG3842	ATPase activity
AFL94_RS02540	COG2801	Transposase and inactivated derivatives
AFL94_RS02560	COG2354	Protein conserved in bacteria
AFL94_RS02595	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AFL94_RS02610	COG0459	protein refolding
AFL94_RS02630	COG2205	protein histidine kinase activity
AFL94_RS02635	COG0745	RESPONSE REGULATOR receiver
AFL94_RS02660	COG1321	iron dependent repressor
AFL94_RS02665	COG0739	heme binding
AFL94_RS02705	COG0045	succinate-CoA ligase (ADP-forming) activity
AFL94_RS02720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AFL94_RS02745	COG1396	sequence-specific DNA binding
AFL94_RS02755	COG0531	amino acid
AFL94_RS02775	COG0028	Belongs to the TPP enzyme family
AFL94_RS02790	COG1846	Transcriptional regulator
AFL94_RS02795	COG2814	Major facilitator Superfamily
AFL94_RS02810	COG2508	Transcriptional regulator
AFL94_RS02815	COG1960	acyl-CoA dehydrogenase activity
AFL94_RS02820	COG1012	belongs to the aldehyde dehydrogenase family
AFL94_RS02825	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFL94_RS02850	COG0519	Catalyzes the synthesis of GMP from XMP
AFL94_RS02865	COG1136	(ABC) transporter
AFL94_RS02865	COG0577	efflux transmembrane transporter activity
AFL94_RS02870	COG0577	efflux transmembrane transporter activity
AFL94_RS02915	COG1295	ribonuclease BN
AFL94_RS02920	COG3583	domain protein
AFL94_RS02925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AFL94_RS02935	COG3483	tryptophan 2,3-dioxygenase activity
AFL94_RS02945	COG3971	2-oxopent-4-enoate hydratase activity
AFL94_RS03000	COG0477	Major facilitator Superfamily
AFL94_RS03010	COG0138	bifunctional purine biosynthesis protein purh
AFL94_RS03015	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AFL94_RS03035	COG1914	H( )-stimulated, divalent metal cation uptake system
AFL94_RS03040	COG4336	lyase activity
AFL94_RS03070	COG4770	biotin carboxylase activity
AFL94_RS03075	COG1984	allophanate hydrolase subunit 2
AFL94_RS03080	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AFL94_RS03090	COG2814	Major facilitator Superfamily
AFL94_RS03100	COG2838	Isocitrate dehydrogenase
AFL94_RS03110	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AFL94_RS03115	COG1802	Transcriptional regulator
AFL94_RS03125	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_RS03160	COG1136	(ABC) transporter
AFL94_RS03195	COG2873	o-acetylhomoserine
AFL94_RS03235	COG3708	Transcriptional regulator
AFL94_RS03235	COG2207	Transcriptional regulator
AFL94_RS03240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AFL94_RS03255	COG2072	flavoprotein involved in K transport
AFL94_RS03260	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AFL94_RS03290	COG2261	transglycosylase associated protein
AFL94_RS03295	COG0477	Major facilitator Superfamily
AFL94_RS03300	COG0583	DNA-binding transcription factor activity
AFL94_RS03310	COG2197	response regulator
AFL94_RS03335	COG0708	Exodeoxyribonuclease III
AFL94_RS03340	COG0180	Tryptophanyl-tRNA synthetase
AFL94_RS03345	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AFL94_RS03360	COG0659	secondary active sulfate transmembrane transporter activity
AFL94_RS03370	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AFL94_RS03375	COG2197	response regulator
AFL94_RS03400	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AFL94_RS03405	COG1053	succinate dehydrogenase
AFL94_RS03415	COG2009	succinate dehydrogenase
AFL94_RS03420	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AFL94_RS03420	COG0662	Cupin 2, conserved barrel domain protein
AFL94_RS03425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AFL94_RS03430	COG1473	amidohydrolase
AFL94_RS03430	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AFL94_RS03435	COG1744	ABC transporter substrate-binding protein PnrA-like
AFL94_RS03440	COG3845	ABC transporter
AFL94_RS03445	COG4603	Belongs to the binding-protein-dependent transport system permease family
AFL94_RS03450	COG1079	Belongs to the binding-protein-dependent transport system permease family
AFL94_RS03470	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AFL94_RS03485	COG0148	phosphopyruvate hydratase activity
AFL94_RS03535	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AFL94_RS03540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AFL94_RS03550	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AFL94_RS03560	COG1331	Highly conserved protein containing a thioredoxin domain
AFL94_RS03565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AFL94_RS03570	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AFL94_RS03590	COG0477	Major facilitator Superfamily
AFL94_RS03615	COG0114	fumarate hydratase activity
AFL94_RS03630	COG1494	fructose-1,6-bisphosphatase
AFL94_RS03640	COG1316	TRANSCRIPTIONal
AFL94_RS03645	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AFL94_RS03705	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
AFL94_RS03730	COG0714	Associated with various cellular activities
AFL94_RS03735	COG0084	hydrolase, TatD family'
AFL94_RS03740	COG3583	domain protein
AFL94_RS03745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFL94_RS03750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AFL94_RS03780	COG0488	(ABC) transporter
AFL94_RS03790	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AFL94_RS03805	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AFL94_RS03810	COG0193	aminoacyl-tRNA hydrolase activity
AFL94_RS03825	COG0822	iron-sulfur transferase activity
AFL94_RS03830	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AFL94_RS03865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFL94_RS03880	COG0477	Major facilitator Superfamily
AFL94_RS03900	COG4770	biotin carboxylase activity
AFL94_RS03910	COG0754	glutathionylspermidine amidase activity
AFL94_RS03920	COG0424	maF-like protein
AFL94_RS03925	COG2409	Drug exporters of the RND superfamily
AFL94_RS03940	COG1823	symporter activity
AFL94_RS03945	COG0640	Transcriptional regulator
AFL94_RS03950	COG0346	lactoylglutathione lyase activity
AFL94_RS03960	COG2814	Major facilitator Superfamily
AFL94_RS03975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AFL94_RS03980	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_RS03980	COG3347	Dehydrogenase
AFL94_RS04005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AFL94_RS04030	COG0363	glucosamine-6-phosphate deaminase activity
AFL94_RS04035	COG1472	Belongs to the glycosyl hydrolase 3 family
AFL94_RS04065	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFL94_RS04070	COG0154	amidase activity
AFL94_RS04075	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFL94_RS04095	COG0747	negative chemotaxis
AFL94_RS04100	COG0601	transmembrane transport
AFL94_RS04110	COG0444	Belongs to the ABC transporter superfamily
AFL94_RS04115	COG4608	Belongs to the ABC transporter superfamily
AFL94_RS04125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFL94_RS04135	COG0477	Major facilitator Superfamily
AFL94_RS04145	COG1063	alcohol dehydrogenase
AFL94_RS04160	COG1653	transport
AFL94_RS04165	COG1175	transmembrane transport
AFL94_RS04170	COG0395	ABC-type sugar transport system, permease component
AFL94_RS04185	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AFL94_RS04190	COG3314	Sporulation integral membrane protein YlbJ
AFL94_RS04195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFL94_RS04200	COG1228	amidohydrolase
AFL94_RS04205	COG1228	amidohydrolase
AFL94_RS04210	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AFL94_RS04220	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AFL94_RS04225	COG1105	Belongs to the carbohydrate kinase PfkB family
AFL94_RS04240	COG1175	transmembrane transport
AFL94_RS04255	COG1349	DNA-binding transcription factor activity
AFL94_RS04285	COG2873	o-acetylhomoserine
AFL94_RS04290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AFL94_RS04295	COG2755	lipolytic protein G-D-S-L family
AFL94_RS04310	COG2501	S4 domain
AFL94_RS04315	COG0423	glycine-tRNA ligase activity
AFL94_RS04360	COG0358	DNA primase activity
AFL94_RS04395	COG1695	Transcriptional regulator
AFL94_RS04410	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AFL94_RS04425	COG0438	transferase activity, transferring glycosyl groups
AFL94_RS04445	COG0438	transferase activity, transferring glycosyl groups
AFL94_RS04460	COG0052	Belongs to the universal ribosomal protein uS2 family
AFL94_RS04465	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AFL94_RS04470	COG0528	UMP kinase activity
AFL94_RS04475	COG0233	cytoplasmic translational termination
AFL94_RS04480	COG0575	Belongs to the CDS family
AFL94_RS04490	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFL94_RS04500	COG3279	Response regulator of the LytR AlgR family
AFL94_RS04505	COG3275	phosphorelay sensor kinase activity
AFL94_RS04515	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFL94_RS04520	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AFL94_RS04525	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFL94_RS04530	COG1215	transferase activity, transferring glycosyl groups
AFL94_RS04545	COG0022	dehydrogenase e1 component
AFL94_RS04550	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFL94_RS04555	COG0747	negative chemotaxis
AFL94_RS04560	COG0601	transmembrane transport
AFL94_RS04565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFL94_RS04585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFL94_RS04605	COG1960	acyl-CoA dehydrogenase activity
AFL94_RS04610	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AFL94_RS04615	COG0750	zinc metalloprotease
AFL94_RS04635	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AFL94_RS04665	COG0442	prolyl-tRNA aminoacylation
AFL94_RS04675	COG2197	response regulator
AFL94_RS04680	COG4585	Histidine kinase
AFL94_RS04705	COG0779	Required for maturation of 30S ribosomal subunits
AFL94_RS04715	COG0481	GTPase activity
AFL94_RS04715	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AFL94_RS04720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AFL94_RS04745	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFL94_RS04755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFL94_RS04770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AFL94_RS04785	COG0196	riboflavin kinase activity
AFL94_RS04795	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AFL94_RS04815	COG1619	proteins homologs of microcin C7 resistance protein MccF
AFL94_RS04845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFL94_RS04850	COG0318	PFAM AMP-dependent synthetase and ligase
AFL94_RS04855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFL94_RS04865	COG0589	response to stress
AFL94_RS04885	COG3290	protein histidine kinase activity
AFL94_RS04890	COG4565	transcriptional regulatory protein
AFL94_RS04900	COG2807	transmembrane transport
AFL94_RS04905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFL94_RS04910	COG1185	polyribonucleotide nucleotidyltransferase activity
AFL94_RS04915	COG2814	Major facilitator Superfamily
AFL94_RS04940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AFL94_RS04965	COG0745	RESPONSE REGULATOR receiver
AFL94_RS04965	COG2205	protein histidine kinase activity
AFL94_RS04965	COG3292	Two component regulator propeller
AFL94_RS04970	COG0028	Belongs to the TPP enzyme family
AFL94_RS05010	COG0251	oxidation-reduction process
AFL94_RS05020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFL94_RS05040	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AFL94_RS05045	COG1053	succinate dehydrogenase
AFL94_RS05050	COG0583	DNA-binding transcription factor activity
AFL94_RS05055	COG0477	Major facilitator Superfamily
AFL94_RS05060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFL94_RS05075	COG1053	succinate dehydrogenase
AFL94_RS05085	COG1063	alcohol dehydrogenase
AFL94_RS05090	COG1053	succinate dehydrogenase
AFL94_RS05100	COG2235	arginine
AFL94_RS05105	COG0612	Peptidase, M16
AFL94_RS05120	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AFL94_RS05135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AFL94_RS05140	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AFL94_RS05155	COG2314	TM2 domain
AFL94_RS05165	COG1174	glycine betaine transport
AFL94_RS05170	COG1174	glycine betaine transport
AFL94_RS05180	COG1674	ftsk spoiiie
AFL94_RS05190	COG1546	Belongs to the CinA family
AFL94_RS05190	COG1058	Belongs to the CinA family
AFL94_RS05205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AFL94_RS05215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFL94_RS05220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AFL94_RS05225	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AFL94_RS05230	COG2813	Specifically methylates the guanine in position
AFL94_RS05235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AFL94_RS05245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AFL94_RS05255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFL94_RS05260	COG0131	Imidazoleglycerol-phosphate dehydratase
AFL94_RS05265	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AFL94_RS05270	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AFL94_RS05290	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AFL94_RS05295	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AFL94_RS05300	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AFL94_RS05305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFL94_RS05310	COG0494	nUDIX hydrolase
AFL94_RS05320	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AFL94_RS05325	COG0072	phenylalanine-tRNA ligase activity
AFL94_RS05325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFL94_RS05345	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AFL94_RS05380	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AFL94_RS05385	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AFL94_RS05390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AFL94_RS05395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AFL94_RS05400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AFL94_RS05405	COG1438	arginine binding
AFL94_RS05415	COG0165	Argininosuccinate lyase
AFL94_RS05425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AFL94_RS05435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AFL94_RS05465	COG0647	UMP catabolic process
AFL94_RS05480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AFL94_RS05485	COG0497	DNA recombination
AFL94_RS05490	COG0504	CTP synthase activity
AFL94_RS05495	COG0494	nUDIX hydrolase
AFL94_RS05500	COG4974	Belongs to the 'phage' integrase family
AFL94_RS05505	COG0494	nUDIX hydrolase
AFL94_RS05510	COG3655	Transcriptional regulator
AFL94_RS05525	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AFL94_RS05530	COG2079	MmgE PrpD family protein
AFL94_RS05555	COG3290	protein histidine kinase activity
AFL94_RS05560	COG1301	dicarboxylic acid transport
AFL94_RS05580	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AFL94_RS05595	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AFL94_RS05600	COG1160	GTP binding
AFL94_RS05610	COG0384	phenazine biosynthesis protein PhzF
AFL94_RS05620	COG0488	(ABC) transporter
AFL94_RS05630	COG3189	MarR family transcriptional regulator
AFL94_RS05635	COG1716	ATPase activity
AFL94_RS05655	COG1192	Involved in chromosome partitioning
AFL94_RS05660	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AFL94_RS05670	COG1022	Amp-dependent synthetase and ligase
AFL94_RS05690	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AFL94_RS05750	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AFL94_RS05755	COG2884	Cell division ATP-binding protein ftsE
AFL94_RS05760	COG2177	Part of the ABC transporter FtsEX involved in
AFL94_RS05765	COG0741	lytic transglycosylase activity
AFL94_RS05765	COG1196	nuclear chromosome segregation
AFL94_RS05765	COG0739	heme binding
AFL94_RS05770	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AFL94_RS05780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AFL94_RS05785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AFL94_RS05790	COG0589	response to stress
AFL94_RS05795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFL94_RS05795	COG1321	iron dependent repressor
AFL94_RS05800	COG0483	inositol monophosphate 1-phosphatase activity
AFL94_RS05810	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AFL94_RS05815	COG1595	DNA-templated transcription, initiation
AFL94_RS05830	COG0567	Dehydrogenase, E1 component
AFL94_RS05830	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFL94_RS05835	COG1253	flavin adenine dinucleotide binding
AFL94_RS05840	COG1253	flavin adenine dinucleotide binding
AFL94_RS05845	COG1121	(ABC) transporter
AFL94_RS05870	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AFL94_RS05880	COG0537	adenosine 5'-monophosphoramidase activity
AFL94_RS05885	COG1643	Atp-dependent helicase
AFL94_RS05900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFL94_RS05900	COG1116	anion transmembrane transporter activity
AFL94_RS05910	COG0018	arginyl-trna synthetase
AFL94_RS05915	COG0019	diaminopimelate decarboxylase activity
AFL94_RS05920	COG0460	homoserine dehydrogenase
AFL94_RS05925	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AFL94_RS05930	COG0083	homoserine kinase activity
AFL94_RS05940	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AFL94_RS05950	COG0009	L-threonylcarbamoyladenylate synthase
AFL94_RS05955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFL94_RS05965	COG0356	it plays a direct role in the translocation of protons across the membrane
AFL94_RS05970	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFL94_RS05975	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AFL94_RS05980	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFL94_RS05985	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AFL94_RS05990	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AFL94_RS05995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AFL94_RS06000	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AFL94_RS06015	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AFL94_RS06065	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AFL94_RS06065	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AFL94_RS06080	COG1335	isochorismatase
AFL94_RS06085	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AFL94_RS06090	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AFL94_RS06100	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AFL94_RS06105	COG1234	tRNA 3'-trailer cleavage
AFL94_RS06120	COG0302	gtp cyclohydrolase
AFL94_RS06135	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AFL94_RS06140	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AFL94_RS06150	COG1131	(ABC) transporter
AFL94_RS06160	COG2176	DNA-directed DNA polymerase activity
AFL94_RS06175	COG0420	3'-5' exonuclease activity
AFL94_RS06180	COG0419	ATPase involved in DNA repair
AFL94_RS06200	COG1609	Transcriptional regulator
AFL94_RS06205	COG0366	Alpha amylase catalytic
AFL94_RS06215	COG1175	transmembrane transport
AFL94_RS06220	COG3833	ABC-type maltose transport systems, permease component
AFL94_RS06235	COG0477	Major facilitator Superfamily
AFL94_RS06260	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AFL94_RS06260	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AFL94_RS06275	COG1335	isochorismatase
AFL94_RS06280	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AFL94_RS06285	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AFL94_RS06295	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AFL94_RS06300	COG1234	tRNA 3'-trailer cleavage
AFL94_RS06315	COG0302	gtp cyclohydrolase
AFL94_RS06330	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AFL94_RS06335	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AFL94_RS06345	COG1131	(ABC) transporter
AFL94_RS06355	COG2176	DNA-directed DNA polymerase activity
AFL94_RS06370	COG0420	3'-5' exonuclease activity
AFL94_RS06375	COG0419	ATPase involved in DNA repair
AFL94_RS06395	COG1609	Transcriptional regulator
AFL94_RS06400	COG0366	Alpha amylase catalytic
AFL94_RS06410	COG1175	transmembrane transport
AFL94_RS06415	COG3833	ABC-type maltose transport systems, permease component
AFL94_RS06430	COG0477	Major facilitator Superfamily
AFL94_RS06445	COG0488	(ABC) transporter
AFL94_RS06455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFL94_RS06470	COG1012	belongs to the aldehyde dehydrogenase family
AFL94_RS06475	COG1802	Transcriptional regulator
AFL94_RS06495	COG0129	dihydroxy-acid dehydratase activity
AFL94_RS06520	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AFL94_RS06525	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AFL94_RS06570	COG1846	Transcriptional regulator
AFL94_RS06580	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AFL94_RS06585	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AFL94_RS06590	COG1256	bacterial-type flagellum assembly
AFL94_RS06605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AFL94_RS06610	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AFL94_RS06625	COG1815	bacterial-type flagellum-dependent cell motility
AFL94_RS06640	COG1766	The M ring may be actively involved in energy transduction
AFL94_RS06655	COG1157	protein secretion by the type III secretion system
AFL94_RS06665	COG0791	NLP P60 protein
AFL94_RS06675	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AFL94_RS06690	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AFL94_RS06715	COG1338	Plays a role in the flagellum-specific transport system
AFL94_RS06730	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFL94_RS06735	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFL94_RS06745	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AFL94_RS06765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFL94_RS06780	COG0579	oxidoreductase
AFL94_RS06790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFL94_RS06805	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AFL94_RS06825	COG1846	Transcriptional regulator
AFL94_RS06830	COG0702	epimerase
AFL94_RS06845	COG0142	geranyltranstransferase activity
AFL94_RS06870	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AFL94_RS06875	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AFL94_RS06900	COG1215	transferase activity, transferring glycosyl groups
AFL94_RS06910	COG0129	dihydroxy-acid dehydratase activity
AFL94_RS06915	COG0028	Belongs to the TPP enzyme family
AFL94_RS06920	COG0440	acetolactate synthase activity
AFL94_RS06925	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AFL94_RS06940	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AFL94_RS06945	COG1088	dTDP-glucose 4,6-dehydratase activity
AFL94_RS06970	COG0673	inositol 2-dehydrogenase activity
AFL94_RS06975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFL94_RS06980	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AFL94_RS07120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFL94_RS07170	COG1432	Conserved Protein
AFL94_RS07180	COG2197	response regulator
AFL94_RS07185	COG4585	Histidine kinase
AFL94_RS07190	COG0473	3-isopropylmalate dehydrogenase activity
AFL94_RS07195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AFL94_RS07200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AFL94_RS07205	COG0179	Fumarylacetoacetate (FAA) hydrolase
AFL94_RS07210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFL94_RS07215	COG0546	phosphoglycolate phosphatase activity
AFL94_RS07235	COG1162	GTPase activity
AFL94_RS07245	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AFL94_RS07255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AFL94_RS07260	COG0066	3-isopropylmalate dehydratase activity
AFL94_RS07265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AFL94_RS07275	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AFL94_RS07280	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFL94_RS07290	COG1316	TRANSCRIPTIONal
AFL94_RS07295	COG1461	Dihydroxyacetone kinase
AFL94_RS07305	COG0742	ribosomal rna small subunit methyltransferase
AFL94_RS07320	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AFL94_RS07325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AFL94_RS07330	COG1316	TRANSCRIPTIONal
AFL94_RS07345	COG1215	transferase activity, transferring glycosyl groups
AFL94_RS07355	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AFL94_RS07360	COG0438	transferase activity, transferring glycosyl groups
AFL94_RS07365	COG1215	transferase activity, transferring glycosyl groups
AFL94_RS07365	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AFL94_RS07375	COG2801	Transposase and inactivated derivatives
AFL94_RS07385	COG0438	transferase activity, transferring glycosyl groups
AFL94_RS07405	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFL94_RS07415	COG1196	nuclear chromosome segregation
AFL94_RS07430	COG2755	lipolytic protein G-D-S-L family
AFL94_RS07430	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AFL94_RS07460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFL94_RS07465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFL94_RS07470	COG2514	catechol 2,3-dioxygenase activity
AFL94_RS07505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFL94_RS07510	COG0183	Belongs to the thiolase family
AFL94_RS07515	COG2837	iron assimilation
AFL94_RS07525	COG0672	)-iron permease
AFL94_RS07565	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AFL94_RS07595	COG1960	acyl-CoA dehydrogenase activity
AFL94_RS07600	COG0242	peptide deformylase activity
AFL94_RS07645	COG3022	response to hydroperoxide
AFL94_RS07650	COG0346	lactoylglutathione lyase activity
AFL94_RS07655	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AFL94_RS07660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFL94_RS07670	COG1045	serine acetyltransferase
AFL94_RS07680	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AFL94_RS07700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AFL94_RS07705	COG2130	NADP-dependent
AFL94_RS07725	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AFL94_RS07735	COG2610	gluconate transmembrane transporter activity
AFL94_RS07740	COG3265	gluconokinase activity
AFL94_RS07745	COG2261	transglycosylase associated protein
AFL94_RS07755	COG1272	protein, Hemolysin III
AFL94_RS07760	COG3237	CsbD-like
AFL94_RS07790	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AFL94_RS07805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFL94_RS07830	COG4974	Belongs to the 'phage' integrase family
AFL94_RS07845	COG0792	nuclease activity
AFL94_RS07855	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AFL94_RS07860	COG0681	Belongs to the peptidase S26 family
AFL94_RS07870	COG0681	Belongs to the peptidase S26 family
AFL94_RS07875	COG0335	large ribosomal subunit rRNA binding
AFL94_RS07880	COG0336	Belongs to the RNA methyltransferase TrmD family
AFL94_RS07885	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AFL94_RS07890	COG1837	Belongs to the UPF0109 family
AFL94_RS07895	COG0228	four-way junction DNA binding
AFL94_RS07900	COG1280	lysine exporter protein (LysE YggA)
AFL94_RS07935	COG0488	(ABC) transporter
AFL94_RS07960	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_RS07965	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_RS07995	COG1119	ATPase activity
AFL94_RS08010	COG0254	rRNA binding
AFL94_RS08015	COG0604	alcohol dehydrogenase
AFL94_RS08020	COG0095	Lipoate-protein ligase
AFL94_RS08085	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_RS08095	COG0438	transferase activity, transferring glycosyl groups
AFL94_RS08110	COG3976	FMN-binding domain protein
AFL94_RS08110	COG1053	succinate dehydrogenase
AFL94_RS08120	COG1914	H( )-stimulated, divalent metal cation uptake system
AFL94_RS08125	COG0745	RESPONSE REGULATOR receiver
AFL94_RS08130	COG2205	protein histidine kinase activity
AFL94_RS08140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFL94_RS08160	COG1968	undecaprenyl-diphosphatase activity
AFL94_RS08165	COG0215	cysteine-tRNA ligase activity
AFL94_RS08175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFL94_RS08180	COG1994	Peptidase M50
AFL94_RS08180	COG0517	IMP dehydrogenase activity
AFL94_RS08190	COG1222	aaa ATPase
AFL94_RS08195	COG4122	O-methyltransferase activity
AFL94_RS08205	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AFL94_RS08210	COG0545	Peptidyl-prolyl cis-trans isomerase
AFL94_RS08230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFL94_RS08235	COG0805	protein transport
AFL94_RS08250	COG1216	Glycosyl transferase, family 2
AFL94_RS08270	COG2226	methyltransferase
AFL94_RS08295	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AFL94_RS08325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFL94_RS08330	COG1845	cytochrome c oxidase, subunit III
AFL94_RS08335	COG2010	Cytochrome c
AFL94_RS08340	COG0723	plastoquinol--plastocyanin reductase activity
AFL94_RS08345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AFL94_RS08355	COG2188	Transcriptional regulator
AFL94_RS08365	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AFL94_RS08370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AFL94_RS08390	COG0167	dihydroorotate dehydrogenase activity
AFL94_RS08395	COG2267	carboxylic ester hydrolase activity
AFL94_RS08400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AFL94_RS08405	COG1381	Involved in DNA repair and RecF pathway recombination
AFL94_RS08410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFL94_RS08420	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AFL94_RS08430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AFL94_RS08445	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AFL94_RS08450	COG0484	heat shock protein binding
AFL94_RS08455	COG1420	regulation of RNA biosynthetic process
AFL94_RS08475	COG0481	GTPase activity
AFL94_RS08485	COG0268	Binds directly to 16S ribosomal RNA
AFL94_RS08495	COG0658	competence protein
AFL94_RS08495	COG2333	competence protein COMEC
AFL94_RS08505	COG1307	EDD domain protein, DegV family
AFL94_RS08510	COG0495	leucyl-tRNA aminoacylation
AFL94_RS08525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AFL94_RS08530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AFL94_RS08540	COG2390	Transcriptional regulator
AFL94_RS08560	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AFL94_RS08570	COG1758	RNA polymerase activity
AFL94_RS08575	COG0194	GDP metabolic process
AFL94_RS08585	COG0284	orotidine-5'-phosphate decarboxylase activity
AFL94_RS08590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AFL94_RS08595	COG0505	Belongs to the CarA family
AFL94_RS08605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AFL94_RS08610	COG0540	Belongs to the ATCase OTCase family
AFL94_RS08615	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AFL94_RS08620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AFL94_RS08625	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AFL94_RS08635	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AFL94_RS08640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AFL94_RS08645	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AFL94_RS08650	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFL94_RS08660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AFL94_RS08665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AFL94_RS08965	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AFL94_RS08975	COG1490	D-aminoacyl-tRNA deacylase activity
AFL94_RS08990	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AFL94_RS08995	COG0124	histidyl-tRNA synthetase
AFL94_RS09000	COG1196	nuclear chromosome segregation
AFL94_RS09010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFL94_RS09015	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFL94_RS09025	COG1862	Preprotein translocase
AFL94_RS09030	COG2255	four-way junction helicase activity
AFL94_RS09035	COG0632	four-way junction helicase activity
AFL94_RS09040	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AFL94_RS09045	COG0217	transcriptional regulatory protein
AFL94_RS09050	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AFL94_RS09060	COG0339	signal peptide processing
AFL94_RS09065	COG0456	acetyltransferase
AFL94_RS09080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AFL94_RS09085	COG0584	glycerophosphoryl diester phosphodiesterase
AFL94_RS09090	COG1653	transport
AFL94_RS09095	COG0395	ABC-type sugar transport system, permease component
AFL94_RS09105	COG1349	DNA-binding transcription factor activity
AFL94_RS09110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFL94_RS09120	COG1131	(ABC) transporter
AFL94_RS09135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AFL94_RS09145	COG0156	8-amino-7-oxononanoate synthase activity
AFL94_RS09150	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AFL94_RS09155	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AFL94_RS09165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AFL94_RS09195	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AFL94_RS09200	COG0587	DNA-directed DNA polymerase activity
AFL94_RS09215	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_RS09220	COG0477	Major facilitator Superfamily
AFL94_RS09225	COG0656	L-ascorbic acid biosynthetic process
AFL94_RS09235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFL94_RS09245	COG2135	peptidase activity
AFL94_RS09285	COG2814	Major facilitator Superfamily
AFL94_RS09295	COG3848	Pyruvate phosphate dikinase
AFL94_RS09295	COG0574	Belongs to the PEP-utilizing enzyme family
AFL94_RS09300	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFL94_RS09305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFL94_RS09310	COG1780	Probably involved in ribonucleotide reductase function
AFL94_RS09320	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AFL94_RS09325	COG0028	Belongs to the TPP enzyme family
AFL94_RS09330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AFL94_RS09340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AFL94_RS09355	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFL94_RS09375	COG0154	amidase activity
AFL94_RS09385	COG0488	(ABC) transporter
AFL94_RS09395	COG1053	succinate dehydrogenase
AFL94_RS09400	COG0583	DNA-binding transcription factor activity
AFL94_RS09415	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_RS09425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFL94_RS09430	COG1113	amino acid transport
AFL94_RS09450	COG0598	Magnesium transport protein CorA
AFL94_RS09495	COG0799	negative regulation of ribosome biogenesis
AFL94_RS09505	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AFL94_RS09515	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AFL94_RS09520	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFL94_RS09525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AFL94_RS09530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AFL94_RS09535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AFL94_RS09540	COG1530	ribonuclease E activity
AFL94_RS09575	COG0105	UTP biosynthetic process
AFL94_RS09585	COG0285	dihydrofolate synthase activity
AFL94_RS09590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AFL94_RS09605	COG4585	Histidine kinase
AFL94_RS09610	COG2197	response regulator
AFL94_RS09615	COG2409	Drug exporters of the RND superfamily
AFL94_RS09625	COG1846	Transcriptional regulator
AFL94_RS09630	COG1764	response to oxidative stress
AFL94_RS09685	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFL94_RS09710	COG0525	valine-tRNA ligase activity
AFL94_RS09720	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AFL94_RS09725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AFL94_RS09730	COG0740	serine-type endopeptidase activity
AFL94_RS09740	COG0544	peptidyl-prolyl cis-trans isomerase activity
AFL94_RS09765	COG0698	ribose 5-phosphate isomerase
AFL94_RS09790	COG1946	Acyl-CoA thioesterase
AFL94_RS09810	COG0629	single-stranded DNA binding
AFL94_RS09830	COG0738	Major facilitator superfamily
AFL94_RS09835	COG1522	sequence-specific DNA binding
AFL94_RS09840	COG1280	lysine exporter protein (LysE YggA)
AFL94_RS09845	COG1122	ATPase activity
AFL94_RS09850	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AFL94_RS09855	COG1268	BioY protein
AFL94_RS09860	COG0318	PFAM AMP-dependent synthetase and ligase
AFL94_RS09870	COG2151	metal-sulfur cluster biosynthetic enzyme
AFL94_RS09875	COG2151	metal-sulfur cluster biosynthetic enzyme
AFL94_RS09880	COG0396	ATPase activity
AFL94_RS09900	COG1131	(ABC) transporter
AFL94_RS09925	COG0109	protoheme IX farnesyltransferase activity
AFL94_RS09935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AFL94_RS09955	COG0363	glucosamine-6-phosphate deaminase activity
AFL94_RS09975	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFL94_RS09980	COG0149	triose-phosphate isomerase activity
AFL94_RS09985	COG0126	phosphoglycerate kinase activity
AFL94_RS10000	COG1481	regulation of sporulation
AFL94_RS10005	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AFL94_RS10010	COG1660	Displays ATPase and GTPase activities
AFL94_RS10015	COG0322	excinuclease ABC activity
AFL94_RS10025	COG0546	phosphoglycolate phosphatase activity
AFL94_RS10060	COG4106	trans-aconitate 2-methyltransferase activity
AFL94_RS10120	COG1846	Transcriptional regulator
AFL94_RS10130	COG0556	nucleotide-excision repair
AFL94_RS10155	COG0237	dephospho-CoA kinase activity
AFL94_RS10165	COG1739	Uncharacterized protein family UPF0029
AFL94_RS10190	COG0539	negative regulation of cytoplasmic translation
AFL94_RS10200	COG4552	Acetyltransferase involved in intracellular survival and related
AFL94_RS10210	COG2050	protein possibly involved in aromatic compounds catabolism
AFL94_RS10240	COG0469	pyruvate kinase activity
AFL94_RS10250	COG0070	glutamate synthase
AFL94_RS10250	COG0069	glutamate synthase activity
AFL94_RS10250	COG0067	glutamate synthase
AFL94_RS10255	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AFL94_RS10260	COG0159	tryptophan synthase activity
AFL94_RS10265	COG0133	tryptophan synthase activity
AFL94_RS10270	COG0134	indole-3-glycerol-phosphate synthase activity
AFL94_RS10290	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AFL94_RS10300	COG0107	imidazoleglycerol-phosphate synthase activity
AFL94_RS10305	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AFL94_RS10310	COG0140	phosphoribosyl-ATP diphosphatase activity
AFL94_RS10315	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AFL94_RS10320	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFL94_RS10320	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFL94_RS10340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AFL94_RS10350	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AFL94_RS10355	COG0242	peptide deformylase activity
AFL94_RS10410	COG3135	benzoate transporter
AFL94_RS10415	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFL94_RS10430	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AFL94_RS10440	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFL94_RS10470	COG0183	Belongs to the thiolase family
AFL94_RS10475	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFL94_RS10475	COG1024	Enoyl-CoA hydratase
AFL94_RS10490	COG0667	Aldo Keto reductase
AFL94_RS10495	COG0137	argininosuccinate synthase activity
AFL94_RS10520	COG3557	Belongs to the UPF0374 family
AFL94_RS10525	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AFL94_RS10570	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AFL94_RS10580	COG0531	amino acid
AFL94_RS10585	COG0569	domain protein
AFL94_RS10610	COG0756	dUTP diphosphatase activity
AFL94_RS10640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFL94_RS10640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AFL94_RS10645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AFL94_RS10650	COG4988	ABC transporter
AFL94_RS10655	COG1294	oxidase, subunit
AFL94_RS10660	COG1271	oxidase subunit
AFL94_RS10675	COG0187	DNA topoisomerase II activity
AFL94_RS10680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AFL94_RS10700	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AFL94_RS10705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFL94_RS10710	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFL94_RS10725	COG0321	lipoyl(octanoyl) transferase activity
AFL94_RS10730	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AFL94_RS10745	COG0174	glutamine synthetase
AFL94_RS10755	COG0590	tRNA wobble adenosine to inosine editing
AFL94_RS10765	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AFL94_RS10770	COG0174	glutamine synthetase
AFL94_RS10775	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AFL94_RS10790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AFL94_RS10795	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AFL94_RS10800	COG0587	DNA-directed DNA polymerase activity
AFL94_RS10810	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AFL94_RS10825	COG1799	cell septum assembly
AFL94_RS10835	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AFL94_RS10840	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AFL94_RS10845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFL94_RS10850	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AFL94_RS10855	COG0772	Belongs to the SEDS family
AFL94_RS10860	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AFL94_RS10865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFL94_RS10890	COG0275	rRNA processing
AFL94_RS10895	COG2001	Belongs to the MraZ family
AFL94_RS10905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AFL94_RS10910	COG0142	geranyltranstransferase activity
AFL94_RS10920	COG3942	CHAP domain
AFL94_RS10920	COG1388	LysM domain
AFL94_RS10930	COG2902	Dehydrogenase
AFL94_RS10960	COG0653	protein targeting
AFL94_RS10965	COG3214	Protein conserved in bacteria
AFL94_RS10970	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AFL94_RS10975	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AFL94_RS10980	COG5401	PFAM Sporulation and spore germination
AFL94_RS10985	COG5002	protein histidine kinase activity
AFL94_RS10990	COG0745	RESPONSE REGULATOR receiver
AFL94_RS11005	COG4172	Belongs to the ABC transporter superfamily
AFL94_RS11010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFL94_RS11015	COG0601	transmembrane transport
AFL94_RS11020	COG4533	DNA binding
AFL94_RS11040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFL94_RS11070	COG0482	sulfurtransferase activity
AFL94_RS11085	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AFL94_RS11105	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AFL94_RS11120	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AFL94_RS11130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFL94_RS11140	COG1842	Phage shock protein A
AFL94_RS11160	COG1615	UPF0182 protein
AFL94_RS11165	COG3480	Lon protease (S16) C-terminal proteolytic domain
AFL94_RS11215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AFL94_RS11220	COG2011	ABC-type metal ion transport system permease component
AFL94_RS11225	COG1464	Belongs to the NlpA lipoprotein family
AFL94_RS11230	COG0531	amino acid
AFL94_RS11235	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AFL94_RS11240	COG0113	porphobilinogen synthase activity
AFL94_RS11250	COG0181	hydroxymethylbilane synthase activity
AFL94_RS11255	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AFL94_RS11260	COG3253	May function as heme-dependent peroxidase
AFL94_RS11265	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AFL94_RS11270	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AFL94_RS11275	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AFL94_RS11280	COG1309	transcriptional regulator
AFL94_RS11300	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AFL94_RS11310	COG0006	proline dipeptidase activity
AFL94_RS11320	COG2239	Acts as a magnesium transporter
AFL94_RS11330	COG0489	protein tyrosine kinase activity
AFL94_RS11330	COG2151	metal-sulfur cluster biosynthetic enzyme
AFL94_RS11340	COG1595	DNA-templated transcription, initiation
AFL94_RS11355	COG1611	Belongs to the LOG family
AFL94_RS11360	COG1126	abc transporter atp-binding protein
AFL94_RS11365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFL94_RS11370	COG0765	amino acid transport
AFL94_RS11375	COG0765	amino acid transport
AFL94_RS11380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFL94_RS11385	COG2171	N-acyltransferase activity
AFL94_RS11415	COG1819	glycosyl
AFL94_RS11430	COG1217	gtp-binding protein TYPA
AFL94_RS11445	COG2022	thiamine diphosphate biosynthetic process
AFL94_RS11455	COG2022	thiamine diphosphate biosynthetic process
AFL94_RS11455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFL94_RS11520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AFL94_RS11525	COG0798	PFAM Bile acid sodium symporter
AFL94_RS11560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFL94_RS11585	COG4044	May play a role in the intracellular transport of hydrophobic ligands
AFL94_RS11610	COG0463	Glycosyl transferase, family 2
AFL94_RS11630	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AFL94_RS11630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFL94_RS11645	COG0012	GTP binding
AFL94_RS11650	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AFL94_RS11655	COG1570	exodeoxyribonuclease VII activity
AFL94_RS11660	COG1722	exodeoxyribonuclease VII activity
AFL94_RS11670	COG2326	polyphosphate kinase activity
AFL94_RS11695	COG1522	sequence-specific DNA binding
AFL94_RS11705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFL94_RS11710	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AFL94_RS11730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AFL94_RS11730	COG0519	Catalyzes the synthesis of GMP from XMP
AFL94_RS11745	COG0516	GMP reductase activity
AFL94_RS11775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AFL94_RS11775	COG2755	lipolytic protein G-D-S-L family
AFL94_RS11790	COG0459	protein refolding
AFL94_RS11795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AFL94_RS11800	COG0833	amino acid
AFL94_RS11815	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AFL94_RS11820	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AFL94_RS11825	COG0456	acetyltransferase
AFL94_RS11830	COG0456	acetyltransferase
AFL94_RS11830	COG1214	PFAM Peptidase M22, glycoprotease
AFL94_RS11835	COG0802	atpase or kinase
AFL94_RS11840	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AFL94_RS11845	COG1970	mechanosensitive ion channel activity
AFL94_RS11850	COG1072	(Pantothenic acid kinase))
AFL94_RS11855	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AFL94_RS11860	COG0736	holo-[acyl-carrier-protein] synthase activity
AFL94_RS11865	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AFL94_RS11865	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AFL94_RS11890	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFL94_RS11895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFL94_RS11900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AFL94_RS11905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AFL94_RS11910	COG0101	tRNA pseudouridine synthase activity
AFL94_RS11920	COG0203	ribosomal protein L17
AFL94_RS11925	COG0202	RNA polymerase activity
AFL94_RS11930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AFL94_RS11935	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AFL94_RS11940	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AFL94_RS11950	COG0563	adenylate kinase activity
AFL94_RS11960	COG0200	Binds to the 23S rRNA
AFL94_RS11965	COG1841	ribosomal large subunit assembly
AFL94_RS11970	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AFL94_RS11975	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AFL94_RS11980	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AFL94_RS11985	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AFL94_RS11990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AFL94_RS11995	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AFL94_RS12000	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AFL94_RS12025	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AFL94_RS12035	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AFL94_RS12040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AFL94_RS12045	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AFL94_RS12050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AFL94_RS12055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AFL94_RS12060	COG0089	rRNA binding
AFL94_RS12065	COG0088	Forms part of the polypeptide exit tunnel
AFL94_RS12070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AFL94_RS12075	COG0051	transcription antitermination factor activity, RNA binding
AFL94_RS12085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFL94_RS12090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AFL94_RS12095	COG0049	tRNA binding
AFL94_RS12100	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AFL94_RS12110	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AFL94_RS12115	COG0085	RNA polymerase activity
AFL94_RS12125	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AFL94_RS12130	COG0222	ribosome binding
AFL94_RS12135	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AFL94_RS12140	COG0081	regulation of translation
AFL94_RS12145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AFL94_RS12150	COG0250	Participates in transcription elongation, termination and antitermination
AFL94_RS12155	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFL94_RS12165	COG0436	Aminotransferase
AFL94_RS12205	COG3485	protocatechuate 3,4-dioxygenase
AFL94_RS12215	COG0745	RESPONSE REGULATOR receiver
AFL94_RS12220	COG0456	acetyltransferase
AFL94_RS12225	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AFL94_RS12230	COG0494	nUDIX hydrolase
AFL94_RS12230	COG0406	alpha-ribazole phosphatase activity
AFL94_RS12240	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AFL94_RS12255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AFL94_RS12260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AFL94_RS12265	COG0738	Major facilitator superfamily
AFL94_RS12275	COG2030	dehydratase
AFL94_RS12300	COG2357	RelA SpoT domain protein
AFL94_RS12345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFL94_RS12355	COG1666	GTP binding
AFL94_RS12360	COG0501	Belongs to the peptidase M48B family
AFL94_RS12375	COG0733	neurotransmitter:sodium symporter activity
AFL94_RS12395	COG0142	geranyltranstransferase activity
AFL94_RS12410	COG0765	amino acid transport
AFL94_RS12415	COG1126	abc transporter atp-binding protein
AFL94_RS12420	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AFL94_RS12430	COG4948	Mandelate Racemase Muconate Lactonizing
AFL94_RS12445	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFL94_RS12450	COG0022	dehydrogenase e1 component
AFL94_RS12460	COG1522	sequence-specific DNA binding
AFL94_RS12465	COG1024	Enoyl-CoA hydratase
AFL94_RS12470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFL94_RS12475	COG2151	metal-sulfur cluster biosynthetic enzyme
AFL94_RS12480	COG3396	Phenylacetate-CoA oxygenase
AFL94_RS12485	COG3460	Phenylacetate-CoA oxygenase
AFL94_RS12490	COG3396	Phenylacetate-CoA oxygenase
AFL94_RS12495	COG2259	Doxx family
AFL94_RS12500	COG1126	abc transporter atp-binding protein
AFL94_RS12505	COG0765	amino acid transport
AFL94_RS12515	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AFL94_RS12520	COG2050	protein possibly involved in aromatic compounds catabolism
AFL94_RS12540	COG1012	belongs to the aldehyde dehydrogenase family
AFL94_RS12540	COG2030	dehydratase
AFL94_RS12545	COG2050	protein possibly involved in aromatic compounds catabolism
AFL94_RS12575	COG1584	GPR1 FUN34 yaaH family protein
AFL94_RS12585	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFL94_RS12590	COG1024	Enoyl-CoA hydratase
AFL94_RS12600	COG0477	Major facilitator Superfamily
AFL94_RS12605	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AFL94_RS12630	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFL94_RS12640	COG0785	Cytochrome C biogenesis protein
AFL94_RS12645	COG3118	belongs to the thioredoxin family
AFL94_RS12650	COG0406	alpha-ribazole phosphatase activity
AFL94_RS12660	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AFL94_RS12680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AFL94_RS12685	COG0640	Transcriptional regulator
AFL94_RS12690	COG0123	including yeast histone deacetylase and acetoin utilization protein
AFL94_RS12695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AFL94_RS12700	COG0569	domain protein
AFL94_RS12715	COG1082	Xylose isomerase domain protein TIM barrel
AFL94_RS12720	COG0248	Ppx GppA phosphatase
AFL94_RS12725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFL94_RS12725	COG1754	DNA topoisomerase type I activity
AFL94_RS12745	COG1054	Belongs to the UPF0176 family
AFL94_RS12755	COG1111	helicase
AFL94_RS12755	COG1205	dead DEAH box helicase
AFL94_RS12800	COG0494	nUDIX hydrolase
AFL94_RS12810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFL94_RS12820	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AFL94_RS12825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFL94_RS12840	COG0251	oxidation-reduction process
AFL94_RS12845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AFL94_RS12855	COG1132	(ABC) transporter
AFL94_RS12860	COG1132	(ABC) transporter
AFL94_RS12865	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AFL94_RS12870	COG0151	Belongs to the GarS family
AFL94_RS12895	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AFL94_RS12905	COG3547	Transposase (IS116 IS110 IS902 family)
AFL94_RS12910	COG3547	Transposase (IS116 IS110 IS902 family)
AFL94_RS12915	COG2197	response regulator
AFL94_RS12920	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AFL94_RS12945	COG3304	Inner membrane component domain
AFL94_RS12950	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AFL94_RS12960	COG0789	Transcriptional regulator
AFL94_RS12965	COG0484	heat shock protein binding
AFL94_RS12970	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AFL94_RS12975	COG0443	Heat shock 70 kDa protein
AFL94_RS12995	COG2409	Drug exporters of the RND superfamily
AFL94_RS13000	COG1846	Transcriptional regulator
AFL94_RS13005	COG1280	lysine exporter protein (LysE YggA)
AFL94_RS13025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFL94_RS13035	COG1122	ATPase activity
AFL94_RS13040	COG4721	ABC-type cobalt transport system, permease component
AFL94_RS13050	COG1320	monovalent cation:proton antiporter activity
AFL94_RS13060	COG1863	multisubunit Na H antiporter MnhE subunit
AFL94_RS13065	COG0651	ATP synthesis coupled electron transport
AFL94_RS13070	COG1006	Multisubunit Na H antiporter MnhC subunit
AFL94_RS13075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFL94_RS13075	COG2111	Na H antiporter
AFL94_RS13085	COG0717	Belongs to the dCTP deaminase family
AFL94_RS13100	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AFL94_RS13100	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AFL94_RS13120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFL94_RS13125	COG0765	amino acid transport
AFL94_RS13130	COG1126	abc transporter atp-binding protein
AFL94_RS13135	COG0433	COG0433 Predicted ATPase
AFL94_RS13145	COG2814	Major facilitator Superfamily
AFL94_RS13170	COG2847	Copper chaperone PCu(A)C
AFL94_RS13185	COG0776	regulation of translation
AFL94_RS13190	COG0776	regulation of translation
AFL94_RS13195	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_RS13205	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AFL94_RS13210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AFL94_RS13215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AFL94_RS13230	COG1176	ABC-type spermidine putrescine transport system, permease component I
AFL94_RS13235	COG3842	ATPase activity
AFL94_RS13255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AFL94_RS13305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFL94_RS13320	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AFL94_RS13370	COG3226	Transcriptional regulator
AFL94_RS13385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFL94_RS13420	COG1902	pentaerythritol trinitrate reductase activity
AFL94_RS13425	COG2239	Acts as a magnesium transporter
AFL94_RS13435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AFL94_RS13440	COG0509	glycine decarboxylation via glycine cleavage system
AFL94_RS13445	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AFL94_RS13450	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFL94_RS13450	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFL94_RS13465	COG0531	amino acid
AFL94_RS13470	COG0328	RNA-DNA hybrid ribonuclease activity
AFL94_RS13480	COG0435	Glutathione S-transferase
AFL94_RS13495	COG1132	(ABC) transporter
AFL94_RS13505	COG1120	ATPase activity
AFL94_RS13510	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFL94_RS13515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFL94_RS13520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFL94_RS13535	COG1136	(ABC) transporter
AFL94_RS13580	COG1309	transcriptional regulator
AFL94_RS13585	COG1960	acyl-CoA dehydrogenase activity
AFL94_RS13590	COG1643	Atp-dependent helicase
AFL94_RS13595	COG2267	carboxylic ester hydrolase activity
AFL94_RS13600	COG0667	Aldo Keto reductase
AFL94_RS13605	COG1012	belongs to the aldehyde dehydrogenase family
AFL94_RS13625	COG2197	response regulator
AFL94_RS13635	COG1528	Iron-storage protein
AFL94_RS13655	COG0823	Involved in the tonB-independent uptake of proteins
AFL94_RS13655	COG1506	peptidase
AFL94_RS13655	COG4946	Tricorn protease homolog
AFL94_RS13665	COG2860	membrane
AFL94_RS13680	COG0477	Major facilitator Superfamily
AFL94_RS13685	COG1278	Cold shock
AFL94_RS13690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFL94_RS13715	COG0583	DNA-binding transcription factor activity
AFL94_RS13725	COG0069	glutamate synthase activity
AFL94_RS13730	COG1132	(ABC) transporter
AFL94_RS13735	COG4988	ABC transporter
AFL94_RS13745	COG0135	phosphoribosylanthranilate isomerase activity
AFL94_RS13755	COG4585	Histidine kinase
AFL94_RS13760	COG2197	response regulator
AFL94_RS13765	COG4152	abc transporter atp-binding protein
AFL94_RS13785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFL94_RS13795	COG0789	Transcriptional regulator
AFL94_RS13810	COG1012	belongs to the aldehyde dehydrogenase family
AFL94_RS13820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFL94_RS13855	COG0561	phosphatase activity
AFL94_RS13870	COG2365	Tyrosine phosphatase family
AFL94_RS13895	COG3191	aminopeptidase activity
AFL94_RS13910	COG1404	Belongs to the peptidase S8 family
AFL94_RS13920	COG1063	alcohol dehydrogenase
AFL94_RS13925	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_RS13945	COG2814	Major facilitator Superfamily
AFL94_RS13960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFL94_RS13975	COG0783	Belongs to the Dps family
AFL94_RS13990	COG2986	histidine ammonia-lyase
AFL94_RS13995	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AFL94_RS14015	COG1869	D-ribose catabolic process
AFL94_RS14020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFL94_RS14025	COG1879	ABC-type sugar transport system periplasmic component
AFL94_RS14030	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFL94_RS14035	COG1129	ABC transporter
AFL94_RS14045	COG1321	iron dependent repressor
AFL94_RS14050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFL94_RS14055	COG2188	Transcriptional regulator
AFL94_RS14075	COG3639	organic phosphonate transmembrane transporter activity
AFL94_RS14080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFL94_RS14085	COG1121	(ABC) transporter
AFL94_RS14115	COG0789	Transcriptional regulator
AFL94_RS14135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AFL94_RS14175	COG0569	domain protein
AFL94_RS14180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AFL94_RS14190	COG1522	sequence-specific DNA binding
AFL94_RS14200	COG2211	Major facilitator Superfamily
AFL94_RS14210	COG2146	nitrite reductase [NAD(P)H] activity
AFL94_RS14225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AFL94_RS14245	COG2188	Transcriptional regulator
AFL94_RS14250	COG1620	l-lactate permease
AFL94_RS14255	COG0247	lactate metabolic process
AFL94_RS14260	COG1139	Iron-sulfur cluster binding protein
AFL94_RS14265	COG1556	Lactate utilization protein
AFL94_RS14290	COG1174	glycine betaine transport
AFL94_RS14300	COG1174	glycine betaine transport
AFL94_RS14305	COG0179	Fumarylacetoacetate (FAA) hydrolase
AFL94_RS14310	COG1115	amino acid carrier protein
AFL94_RS14315	COG2301	Belongs to the HpcH HpaI aldolase family
AFL94_RS14320	COG1113	amino acid transport
AFL94_RS14345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFL94_RS14355	COG2050	protein possibly involved in aromatic compounds catabolism
AFL94_RS14360	COG1414	Transcriptional regulator
AFL94_RS14365	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AFL94_RS14365	COG1082	Xylose isomerase domain protein TIM barrel
AFL94_RS14370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFL94_RS14375	COG0477	Major facilitator Superfamily
AFL94_RS14380	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_RS14390	COG0583	DNA-binding transcription factor activity
AFL94_RS14400	COG0583	DNA-binding transcription factor activity
AFL94_RS14405	COG2855	membrane
AFL94_RS14420	COG1960	acyl-CoA dehydrogenase activity
AFL94_RS14425	COG2149	membrane
AFL94_RS14440	COG0477	Major facilitator Superfamily
AFL94_RS14450	COG1733	regulation of RNA biosynthetic process
AFL94_RS14470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFL94_RS14490	COG0318	PFAM AMP-dependent synthetase and ligase
AFL94_RS14505	COG2814	Major facilitator Superfamily
AFL94_RS14560	COG1414	Transcriptional regulator
AFL94_RS14580	COG0183	Belongs to the thiolase family
AFL94_RS14585	COG0588	phosphoglycerate mutase activity
AFL94_RS14590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AFL94_RS14595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFL94_RS14600	COG0028	Belongs to the TPP enzyme family
AFL94_RS14615	COG2186	Transcriptional regulator
AFL94_RS14625	COG1027	Aspartate ammonia-lyase
AFL94_RS14635	COG0823	Involved in the tonB-independent uptake of proteins
AFL94_RS14635	COG1506	peptidase
AFL94_RS14660	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFL94_RS14665	COG0022	dehydrogenase e1 component
AFL94_RS14675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFL94_RS14680	COG1950	PFAM Membrane protein of
AFL94_RS14695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AFL94_RS14700	COG2223	nitrite transmembrane transporter activity
AFL94_RS14705	COG0243	molybdopterin cofactor binding
AFL94_RS14710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFL94_RS14720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFL94_RS14720	COG2146	nitrite reductase [NAD(P)H] activity
AFL94_RS14725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AFL94_RS14725	COG1648	precorrin-2 dehydrogenase activity
AFL94_RS14735	COG0667	Aldo Keto reductase
AFL94_RS14745	COG0277	FAD linked oxidase domain protein
AFL94_RS14765	COG2233	PERMEase
AFL94_RS14775	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AFL94_RS14790	COG0318	PFAM AMP-dependent synthetase and ligase
AFL94_RS14805	COG2197	response regulator
AFL94_RS14810	COG4585	Histidine kinase
AFL94_RS14820	COG1131	(ABC) transporter
AFL94_RS14840	COG0006	proline dipeptidase activity
AFL94_RS14865	COG0436	Aminotransferase
AFL94_RS14870	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFL94_RS14885	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AFL94_RS14890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFL94_RS14895	COG2226	methyltransferase
AFL94_RS14935	COG2957	Belongs to the agmatine deiminase family
AFL94_RS14940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFL94_RS14980	COG2066	Belongs to the glutaminase family
AFL94_RS14985	COG1607	acyl-coa hydrolase
AFL94_RS15010	COG3850	Histidine kinase
AFL94_RS15030	COG1842	Phage shock protein A
AFL94_RS15075	COG2807	transmembrane transport
AFL94_RS15100	COG1937	Protein conserved in bacteria
AFL94_RS15115	COG1289	transmembrane transporter activity
AFL94_RS15125	COG1113	amino acid transport
AFL94_RS15135	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AFL94_RS15140	COG0531	amino acid
AFL94_RS15145	COG2154	pterin-4-alpha-carbinolamine dehydratase
AFL94_RS15165	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AFL94_RS15170	COG0531	amino acid
AFL94_RS15190	COG0477	Major facilitator Superfamily
AFL94_RS15200	COG0534	Mate efflux family protein
AFL94_RS15210	COG2814	Major facilitator Superfamily
AFL94_RS15215	COG1266	CAAX protease self-immunity
AFL94_RS15225	COG0747	negative chemotaxis
AFL94_RS15230	COG0601	transmembrane transport
AFL94_RS15235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFL94_RS15260	COG0583	DNA-binding transcription factor activity
AFL94_RS15270	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AFL94_RS15300	COG2030	dehydratase
AFL94_RS15305	COG0318	PFAM AMP-dependent synthetase and ligase
AFL94_RS15315	COG1960	acyl-CoA dehydrogenase activity
AFL94_RS15320	COG1960	acyl-CoA dehydrogenase activity
AFL94_RS15330	COG2030	dehydratase
AFL94_RS15360	COG0477	Major facilitator Superfamily
AFL94_RS15365	COG1012	belongs to the aldehyde dehydrogenase family
AFL94_RS15385	COG1309	transcriptional regulator
AFL94_RS15395	COG1960	acyl-CoA dehydrogenase activity
AFL94_RS15425	COG0501	Belongs to the peptidase M48B family
AFL94_RS15435	COG0583	DNA-binding transcription factor activity
AFL94_RS15440	COG0477	Major facilitator Superfamily
AFL94_RS15445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFL94_RS15450	COG0154	amidase activity
AFL94_RS15460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFL94_RS15470	COG2154	pterin-4-alpha-carbinolamine dehydratase
AFL94_RS15480	COG2323	membrane
AFL94_RS15485	COG0531	amino acid
AFL94_RS15495	COG1335	isochorismatase
AFL94_RS15515	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_RS15530	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AFL94_RS15535	COG3285	dna ligase
AFL94_RS15535	COG1793	dna ligase
AFL94_RS15545	COG1012	belongs to the aldehyde dehydrogenase family
AFL94_RS15555	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AFL94_RS15570	COG0415	Belongs to the DNA photolyase family
AFL94_RS15595	COG1012	belongs to the aldehyde dehydrogenase family
AFL94_RS15600	COG0028	Belongs to the TPP enzyme family
AFL94_RS15615	COG0477	Major facilitator Superfamily
AFL94_RS15625	COG2508	Transcriptional regulator
AFL94_RS15715	COG1122	ATPase activity
AFL94_RS15745	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AFL94_RS15765	COG1414	Transcriptional regulator
AFL94_RS15775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFL94_RS15775	COG0574	Belongs to the PEP-utilizing enzyme family
AFL94_RS15780	COG3848	Pyruvate phosphate dikinase
AFL94_RS15780	COG0574	Belongs to the PEP-utilizing enzyme family
AFL94_RS15785	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_RS15810	COG2066	Belongs to the glutaminase family
AFL94_RS15850	COG2755	lipolytic protein G-D-S-L family
AFL94_RS15850	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AFL94_RS15860	COG0745	RESPONSE REGULATOR receiver
AFL94_RS15865	COG2205	protein histidine kinase activity
AFL94_RS15880	COG2855	membrane
AFL94_RS15900	COG1295	ribonuclease BN
AFL94_RS15910	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AFL94_RS15915	COG3960	tartronate-semialdehyde synthase activity
AFL94_RS15920	COG2084	Dehydrogenase
AFL94_RS15925	COG3622	Belongs to the hyi family
AFL94_RS15930	COG1953	Uracil, thiamine, allantoin
AFL94_RS15955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFL94_RS15960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFL94_RS15995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFL94_RS16010	COG0738	Major facilitator superfamily
AFL94_RS16020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AFL94_RS16070	COG2267	carboxylic ester hydrolase activity
AFL94_RS16075	COG1929	Belongs to the glycerate kinase type-1 family
AFL94_RS16090	COG0659	secondary active sulfate transmembrane transporter activity
AFL94_RS16100	COG2203	Gaf domain
AFL94_RS16100	COG2200	EAL domain
AFL94_RS16100	COG2199	diguanylate cyclase activity
AFL94_RS16115	COG0318	PFAM AMP-dependent synthetase and ligase
AFL94_RS16185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AFL94_RS16195	COG0477	Major facilitator Superfamily
AFL94_RS16205	COG1414	Transcriptional regulator
AFL94_RS16215	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AFL94_RS16220	COG1940	carbohydrate kinase activity
AFL94_RS16225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AFL94_RS16230	COG4608	Belongs to the ABC transporter superfamily
AFL94_RS16235	COG0444	Belongs to the ABC transporter superfamily
AFL94_RS16240	COG0601	transmembrane transport
AFL94_RS16245	COG0747	negative chemotaxis
AFL94_RS16250	COG2186	Transcriptional regulator
AFL94_RS16260	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AFL94_RS16275	COG3012	SEC-C Motif Domain Protein
AFL94_RS16280	COG1414	Transcriptional regulator
AFL94_RS16290	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AFL94_RS16295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFL94_RS16325	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AFL94_RS16340	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_RS16345	COG1024	Enoyl-CoA hydratase
AFL94_RS16380	COG0477	Major facilitator Superfamily
AFL94_RS16385	COG0183	Belongs to the thiolase family
AFL94_RS16395	COG1960	acyl-CoA dehydrogenase activity
AFL94_RS16400	COG1024	Enoyl-CoA hydratase
AFL94_RS16405	COG1960	acyl-CoA dehydrogenase activity
AFL94_RS16410	COG1960	acyl-CoA dehydrogenase activity
AFL94_RS16415	COG1960	acyl-CoA dehydrogenase activity
AFL94_RS16440	COG0183	Belongs to the thiolase family
AFL94_RS16455	COG0477	Major facilitator Superfamily
AFL94_RS16460	COG1902	pentaerythritol trinitrate reductase activity
AFL94_RS16500	COG1733	regulation of RNA biosynthetic process
AFL94_RS16540	COG0739	heme binding
AFL94_RS16540	COG0741	lytic transglycosylase activity
AFL94_RS16540	COG1196	nuclear chromosome segregation
AFL94_RS16555	COG1476	TRANSCRIPTIONal
AFL94_RS16560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AFL94_RS16565	COG0305	Participates in initiation and elongation during chromosome replication
AFL94_RS16575	COG0477	Major facilitator Superfamily
AFL94_RS16595	COG1846	Transcriptional regulator
AFL94_RS16610	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_RS16645	COG2351	hydroxyisourate hydrolase activity
AFL94_RS16655	COG2233	PERMEase
AFL94_RS16675	COG0531	amino acid
AFL94_RS16700	COG4221	oxidoreductase activity
AFL94_RS16715	COG2814	Major facilitator Superfamily
AFL94_RS16720	COG1113	amino acid transport
AFL94_RS16730	COG1940	carbohydrate kinase activity
AFL94_RS16740	COG0673	inositol 2-dehydrogenase activity
AFL94_RS16750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFL94_RS16760	COG3962	Belongs to the TPP enzyme family
AFL94_RS16775	COG0673	inositol 2-dehydrogenase activity
AFL94_RS16780	COG1082	Xylose isomerase domain protein TIM barrel
AFL94_RS16785	COG2814	Major facilitator Superfamily
AFL94_RS16790	COG0589	response to stress
AFL94_RS16800	COG1609	Transcriptional regulator
AFL94_RS16805	COG0673	inositol 2-dehydrogenase activity
AFL94_RS16810	COG1082	Xylose isomerase domain protein TIM barrel
AFL94_RS16815	COG3718	enzyme involved in inositol metabolism
AFL94_RS16820	COG2188	Transcriptional regulator
AFL94_RS16840	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFL94_RS16855	COG1082	Xylose isomerase domain protein TIM barrel
AFL94_RS16860	COG0673	inositol 2-dehydrogenase activity
AFL94_RS16870	COG0673	inositol 2-dehydrogenase activity
AFL94_RS16885	COG2217	Heavy metal translocating P-type atpase
AFL94_RS16890	COG1132	(ABC) transporter
AFL94_RS16895	COG1053	succinate dehydrogenase
AFL94_RS16915	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AFL94_RS16925	COG3257	ureidoglycine aminohydrolase activity
AFL94_RS16940	COG0346	lactoylglutathione lyase activity
AFL94_RS16955	COG2267	carboxylic ester hydrolase activity
AFL94_RS16960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFL94_RS16985	COG0318	PFAM AMP-dependent synthetase and ligase
AFL94_RS16995	COG1136	(ABC) transporter
AFL94_RS17025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AFL94_RS17030	COG0477	Major facilitator Superfamily
AFL94_RS17070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AFL94_RS17075	COG0798	PFAM Bile acid sodium symporter
AFL94_RS17090	COG1309	transcriptional regulator
AFL94_RS17095	COG2267	carboxylic ester hydrolase activity
AFL94_RS17120	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_RS17125	COG0477	Major facilitator Superfamily
AFL94_RS17130	COG0477	Major facilitator Superfamily
AFL94_RS17135	COG0183	Belongs to the thiolase family
AFL94_RS17160	COG3547	Transposase (IS116 IS110 IS902 family)
AFL94_RS17165	COG3547	Transposase (IS116 IS110 IS902 family)
AFL94_RS17190	COG2801	Transposase and inactivated derivatives
AFL94_RS17260	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AFL94_RS17265	COG2161	toxin-antitoxin pair type II binding
AFL94_RS17305	COG1597	lipid kinase activity
AFL94_RS17330	COG0318	PFAM AMP-dependent synthetase and ligase
AFL94_RS17340	COG2133	pyrroloquinoline quinone binding
AFL94_RS17375	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AFL94_RS17380	COG0359	binds to the 23S rRNA
AFL94_RS17385	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AFL94_RS17395	COG0360	Binds together with S18 to 16S ribosomal RNA
AFL94_RS17400	COG2755	lipolytic protein G-D-S-L family
AFL94_RS17400	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AFL94_RS17405	COG0579	oxidoreductase
AFL94_RS17420	COG1362	aminopeptidase activity
AFL94_RS17430	COG2197	response regulator
AFL94_RS17435	COG4585	Histidine kinase
AFL94_RS17470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFL94_RS17490	COG0179	Fumarylacetoacetate (FAA) hydrolase
AFL94_RS17510	COG2423	ornithine cyclodeaminase activity
AFL94_RS17530	COG1129	ABC transporter
AFL94_RS17535	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFL94_RS17545	COG1902	pentaerythritol trinitrate reductase activity
AFL94_RS17545	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFL94_RS17550	COG2050	protein possibly involved in aromatic compounds catabolism
AFL94_RS17550	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AFL94_RS17555	COG0183	Belongs to the thiolase family
AFL94_RS17560	COG1309	transcriptional regulator
AFL94_RS17570	COG2207	Transcriptional regulator
AFL94_RS17595	COG1028	Short-chain dehydrogenase reductase Sdr
AFL94_RS17625	COG2089	acid synthase
AFL94_RS17630	COG1216	Glycosyl transferase, family 2
AFL94_RS17630	COG1442	glycosyl transferase family 8
AFL94_RS17650	COG1260	myo-inositol-1-phosphate synthase
AFL94_RS17655	COG0617	tRNA 3'-terminal CCA addition
AFL94_RS17675	COG0492	ferredoxin-NADP+ reductase activity
AFL94_RS17680	COG3118	belongs to the thioredoxin family
AFL94_RS17690	COG1475	DNA binding
AFL94_RS17695	COG1192	Involved in chromosome partitioning
AFL94_RS17700	COG0357	Ribosomal RNA small subunit methyltransferase G
AFL94_RS17710	COG0706	membrane insertase activity
AFL94_RS17715	COG0759	Could be involved in insertion of integral membrane proteins into the membrane