locus-tag	class	description
OW521_RS00025	COG3119	arylsulfatase activity
OW521_RS00035	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OW521_RS00070	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
OW521_RS00075	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
OW521_RS00085	COG2124	cytochrome p450
OW521_RS00115	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
OW521_RS00120	COG0439	Biotin carboxylase
OW521_RS00140	COG0583	DNA-binding transcription factor activity
OW521_RS00145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OW521_RS00160	COG0596	Alpha beta hydrolase
OW521_RS00190	COG1024	Enoyl-CoA hydratase
OW521_RS00195	COG1250	3-hydroxyacyl-CoA dehydrogenase
OW521_RS00210	COG2271	Major facilitator Superfamily
OW521_RS00240	COG2855	membrane
OW521_RS00270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OW521_RS00310	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OW521_RS00315	COG0121	glutamine amidotransferase
OW521_RS00320	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
OW521_RS00325	COG1104	cysteine desulfurase activity
OW521_RS00365	COG3654	unkown
OW521_RS00380	COG0747	negative chemotaxis
OW521_RS00395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OW521_RS00425	COG0183	Belongs to the thiolase family
OW521_RS00435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OW521_RS00475	COG0477	Major facilitator Superfamily
OW521_RS00480	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS00520	COG1414	Transcriptional regulator
OW521_RS00545	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS00560	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS00585	COG0477	Major facilitator Superfamily
OW521_RS00645	COG0747	negative chemotaxis
OW521_RS00675	COG2186	Transcriptional regulator
OW521_RS00735	COG1355	regulation of microtubule-based process
OW521_RS00745	COG2188	Transcriptional regulator
OW521_RS00785	COG3387	PFAM Glycoside hydrolase 15-related
OW521_RS00800	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OW521_RS00820	COG0145	ligase activity
OW521_RS00825	COG4647	ligase activity
OW521_RS00830	COG0145	ligase activity
OW521_RS00840	COG0667	Aldo Keto reductase
OW521_RS00860	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS00865	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS00915	COG3619	membrane
OW521_RS00920	COG1012	belongs to the aldehyde dehydrogenase family
OW521_RS00940	COG0395	ABC-type sugar transport system, permease component
OW521_RS00955	COG2186	Transcriptional regulator
OW521_RS00960	COG4948	Mandelate Racemase Muconate Lactonizing
OW521_RS00985	COG0179	Fumarylacetoacetate (FAA) hydrolase
OW521_RS00990	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS01000	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS01010	COG1937	Protein conserved in bacteria
OW521_RS01015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OW521_RS01030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OW521_RS01040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OW521_RS01130	COG1396	sequence-specific DNA binding
OW521_RS01135	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
OW521_RS01155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OW521_RS01175	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
OW521_RS01190	COG2186	Transcriptional regulator
OW521_RS01195	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS01200	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OW521_RS01205	COG1609	Transcriptional regulator
OW521_RS01215	COG0427	acetyl-CoA hydrolase
OW521_RS01220	COG1960	acyl-CoA dehydrogenase activity
OW521_RS01230	COG1064	alcohol dehydrogenase
OW521_RS01260	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS01270	COG1172	Belongs to the binding-protein-dependent transport system permease family
OW521_RS01275	COG1129	ABC transporter
OW521_RS01285	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS01315	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS01320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_RS01325	COG2030	dehydratase
OW521_RS01350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OW521_RS01365	COG4569	acetaldehyde dehydrogenase (acetylating) activity
OW521_RS01380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OW521_RS01440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OW521_RS01450	COG2151	metal-sulfur cluster biosynthetic enzyme
OW521_RS01485	COG3350	monooxygenase activity
OW521_RS01610	COG1053	succinate dehydrogenase
OW521_RS01615	COG1414	Transcriptional regulator
OW521_RS01625	COG1053	succinate dehydrogenase
OW521_RS01640	COG0154	amidase activity
OW521_RS01645	COG0477	Major facilitator Superfamily
OW521_RS01655	COG2902	Dehydrogenase
OW521_RS01710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OW521_RS01715	COG1414	Transcriptional regulator
OW521_RS01740	COG2267	carboxylic ester hydrolase activity
OW521_RS01755	COG4638	Rieske (2fe-2S)
OW521_RS01765	COG0318	PFAM AMP-dependent synthetase and ligase
OW521_RS01770	COG3971	2-oxopent-4-enoate hydratase activity
OW521_RS01785	COG0559	Belongs to the binding-protein-dependent transport system permease family
OW521_RS01805	COG4569	acetaldehyde dehydrogenase (acetylating) activity
OW521_RS01825	COG1024	Enoyl-CoA hydratase
OW521_RS01845	COG2086	electron transfer activity
OW521_RS01850	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
OW521_RS01865	COG3347	Dehydrogenase
OW521_RS01865	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS01870	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS01870	COG3321	synthase
OW521_RS01870	COG0604	alcohol dehydrogenase
OW521_RS01875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_RS01880	COG2814	Major facilitator Superfamily
OW521_RS01905	COG2365	Tyrosine phosphatase family
OW521_RS01920	COG0302	gtp cyclohydrolase
OW521_RS01930	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OW521_RS01935	COG1215	transferase activity, transferring glycosyl groups
OW521_RS01950	COG2814	Major facilitator Superfamily
OW521_RS01955	COG0604	alcohol dehydrogenase
OW521_RS01975	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
OW521_RS01975	COG0825	malonyl-CoA metabolic process
OW521_RS02015	COG1960	acyl-CoA dehydrogenase activity
OW521_RS02020	COG1960	acyl-CoA dehydrogenase activity
OW521_RS02040	COG1960	acyl-CoA dehydrogenase activity
OW521_RS02045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_RS02055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OW521_RS02060	COG1024	Enoyl-CoA hydratase
OW521_RS02080	COG0406	alpha-ribazole phosphatase activity
OW521_RS02105	COG2079	MmgE PrpD family protein
OW521_RS02110	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
OW521_RS02120	COG0563	adenylate kinase activity
OW521_RS02145	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
OW521_RS02150	COG0667	Aldo Keto reductase
OW521_RS02155	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OW521_RS02165	COG0183	Belongs to the thiolase family
OW521_RS02180	COG2124	cytochrome p450
OW521_RS02195	COG1024	Enoyl-CoA hydratase
OW521_RS02205	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
OW521_RS02210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_RS02245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_RS02250	COG2130	NADP-dependent
OW521_RS02275	COG2124	cytochrome p450
OW521_RS02295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OW521_RS02305	COG2814	Major facilitator Superfamily
OW521_RS02310	COG2814	Major facilitator Superfamily
OW521_RS02315	COG2814	Major facilitator Superfamily
OW521_RS02380	COG1473	amidohydrolase
OW521_RS02415	COG3547	Transposase (IS116 IS110 IS902 family)
OW521_RS02420	COG4974	Belongs to the 'phage' integrase family
OW521_RS02435	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OW521_RS02590	COG0067	glutamate synthase
OW521_RS02590	COG0069	glutamate synthase activity
OW521_RS02590	COG0070	glutamate synthase
OW521_RS02595	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
OW521_RS02600	COG0159	tryptophan synthase activity
OW521_RS02605	COG0133	tryptophan synthase activity
OW521_RS02610	COG0134	indole-3-glycerol-phosphate synthase activity
OW521_RS02630	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OW521_RS02640	COG0107	imidazoleglycerol-phosphate synthase activity
OW521_RS02645	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OW521_RS02650	COG0140	phosphoribosyl-ATP diphosphatase activity
OW521_RS02655	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
OW521_RS02660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OW521_RS02660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OW521_RS02685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OW521_RS02695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
OW521_RS02700	COG0242	peptide deformylase activity
OW521_RS02710	COG3706	GGDEF domain
OW521_RS02775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OW521_RS02790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OW521_RS02820	COG0183	Belongs to the thiolase family
OW521_RS02825	COG1024	Enoyl-CoA hydratase
OW521_RS02825	COG1250	3-hydroxyacyl-CoA dehydrogenase
OW521_RS02835	COG0667	Aldo Keto reductase
OW521_RS02850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
OW521_RS02855	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
OW521_RS02860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OW521_RS02865	COG0531	amino acid
OW521_RS02870	COG0569	domain protein
OW521_RS02895	COG0756	dUTP diphosphatase activity
OW521_RS02915	COG1435	thymidine kinase activity
OW521_RS02930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OW521_RS02930	COG1042	CoA-binding domain protein
OW521_RS02930	COG0045	succinate-CoA ligase (ADP-forming) activity
OW521_RS02935	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OW521_RS02955	COG4988	ABC transporter
OW521_RS02960	COG1294	oxidase, subunit
OW521_RS02965	COG1271	oxidase subunit
OW521_RS03000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OW521_RS03005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OW521_RS03025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OW521_RS03030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OW521_RS03035	COG0508	dehydrogenase complex catalyzes the overall conversion of
OW521_RS03045	COG1764	response to oxidative stress
OW521_RS03050	COG0793	Belongs to the peptidase S41A family
OW521_RS03050	COG4946	Tricorn protease homolog
OW521_RS03055	COG1090	epimerase
OW521_RS03065	COG0321	lipoyl(octanoyl) transferase activity
OW521_RS03070	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OW521_RS03100	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
OW521_RS03105	COG0174	glutamine synthetase
OW521_RS03110	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
OW521_RS03130	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OW521_RS03135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OW521_RS03150	COG0587	DNA-directed DNA polymerase activity
OW521_RS03160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OW521_RS03165	COG3599	regulation of cell shape
OW521_RS03175	COG1799	cell septum assembly
OW521_RS03180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
OW521_RS03185	COG1496	oxidoreductase activity
OW521_RS03190	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OW521_RS03200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OW521_RS03205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OW521_RS03215	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
OW521_RS03220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OW521_RS03230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OW521_RS03235	COG0768	penicillin binding
OW521_RS03245	COG0275	rRNA processing
OW521_RS03250	COG2001	Belongs to the MraZ family
OW521_RS03260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OW521_RS03270	COG0142	geranyltranstransferase activity
OW521_RS03285	COG0515	serine threonine protein kinase
OW521_RS03285	COG2815	serine threonine protein kinase
OW521_RS03290	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
OW521_RS03310	COG1940	carbohydrate kinase activity
OW521_RS03320	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
OW521_RS03325	COG1192	Involved in chromosome partitioning
OW521_RS03345	COG1716	ATPase activity
OW521_RS03350	COG0509	glycine decarboxylation via glycine cleavage system
OW521_RS03355	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OW521_RS03360	COG2814	Major facilitator Superfamily
OW521_RS03370	COG2824	Alkylphosphonate utilization operon protein PhnA
OW521_RS03380	COG1160	GTP binding
OW521_RS03390	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
OW521_RS03395	COG0287	Prephenate dehydrogenase
OW521_RS03410	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
OW521_RS03420	COG1301	dicarboxylic acid transport
OW521_RS03425	COG3290	protein histidine kinase activity
OW521_RS03430	COG4565	transcriptional regulatory protein
OW521_RS03440	COG2079	MmgE PrpD family protein
OW521_RS03445	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
OW521_RS03475	COG1595	DNA-templated transcription, initiation
OW521_RS03485	COG0494	nUDIX hydrolase
OW521_RS03490	COG0504	CTP synthase activity
OW521_RS03495	COG0497	DNA recombination
OW521_RS03500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OW521_RS03515	COG0647	UMP catabolic process
OW521_RS03555	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OW521_RS03570	COG2094	Belongs to the DNA glycosylase MPG family
OW521_RS03585	COG0165	Argininosuccinate lyase
OW521_RS03590	COG0137	argininosuccinate synthase activity
OW521_RS03595	COG1438	arginine binding
OW521_RS03600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
OW521_RS03605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OW521_RS03610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OW521_RS03615	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
OW521_RS03620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
OW521_RS03650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OW521_RS03650	COG0072	phenylalanine-tRNA ligase activity
OW521_RS03655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
OW521_RS03660	COG2968	Membrane
OW521_RS03680	COG2814	Major facilitator Superfamily
OW521_RS03690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OW521_RS03695	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
OW521_RS03700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
OW521_RS03705	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
OW521_RS03725	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
OW521_RS03735	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OW521_RS03740	COG0131	Imidazoleglycerol-phosphate dehydratase
OW521_RS03745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OW521_RS03755	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OW521_RS03765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OW521_RS03775	COG2813	Specifically methylates the guanine in position
OW521_RS03780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
OW521_RS03785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
OW521_RS03790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OW521_RS03800	COG2137	regulation of response to DNA damage stimulus
OW521_RS03805	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
OW521_RS03820	COG1396	sequence-specific DNA binding
OW521_RS03825	COG1058	Belongs to the CinA family
OW521_RS03825	COG1546	Belongs to the CinA family
OW521_RS03835	COG1674	ftsk spoiiie
OW521_RS03840	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
OW521_RS03860	COG2801	Transposase and inactivated derivatives
OW521_RS03870	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
OW521_RS03880	COG0521	Mo-molybdopterin cofactor biosynthetic process
OW521_RS03900	COG5002	protein histidine kinase activity
OW521_RS03905	COG0745	RESPONSE REGULATOR receiver
OW521_RS03930	COG0612	Peptidase, M16
OW521_RS03935	COG1185	polyribonucleotide nucleotidyltransferase activity
OW521_RS03940	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
OW521_RS03945	COG3483	tryptophan 2,3-dioxygenase activity
OW521_RS03965	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OW521_RS03970	COG0436	Aminotransferase
OW521_RS03975	COG0590	tRNA wobble adenosine to inosine editing
OW521_RS03980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
OW521_RS03985	COG0481	GTPase activity
OW521_RS03985	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
OW521_RS04000	COG0779	Required for maturation of 30S ribosomal subunits
OW521_RS04020	COG0076	glutamate decarboxylase activity
OW521_RS04030	COG0442	prolyl-tRNA aminoacylation
OW521_RS04035	COG1131	(ABC) transporter
OW521_RS04045	COG1309	transcriptional regulator
OW521_RS04055	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
OW521_RS04065	COG0750	zinc metalloprotease
OW521_RS04070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
OW521_RS04100	COG1960	acyl-CoA dehydrogenase activity
OW521_RS04110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OW521_RS04120	COG2801	Transposase and inactivated derivatives
OW521_RS04120	COG3415	Transposase
OW521_RS04125	COG0508	dehydrogenase complex catalyzes the overall conversion of
OW521_RS04130	COG0022	dehydrogenase e1 component
OW521_RS04140	COG1522	sequence-specific DNA binding
OW521_RS04155	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OW521_RS04165	COG3275	phosphorelay sensor kinase activity
OW521_RS04180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OW521_RS04190	COG0575	Belongs to the CDS family
OW521_RS04195	COG0233	cytoplasmic translational termination
OW521_RS04200	COG0528	UMP kinase activity
OW521_RS04205	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
OW521_RS04210	COG0052	Belongs to the universal ribosomal protein uS2 family
OW521_RS04220	COG1960	acyl-CoA dehydrogenase activity
OW521_RS04240	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OW521_RS04245	COG0667	Aldo Keto reductase
OW521_RS04260	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS04265	COG2326	polyphosphate kinase activity
OW521_RS04315	COG0297	glycogen (starch) synthase activity
OW521_RS04320	COG3300	MHYT domain
OW521_RS04320	COG5001	Diguanylate cyclase
OW521_RS04340	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OW521_RS04355	COG0688	phosphatidylethanolamine metabolic process
OW521_RS04445	COG0784	Response regulator, receiver
OW521_RS04445	COG5002	protein histidine kinase activity
OW521_RS04445	COG2198	Histidine kinase
OW521_RS04450	COG5002	protein histidine kinase activity
OW521_RS04450	COG2205	protein histidine kinase activity
OW521_RS04450	COG0784	Response regulator, receiver
OW521_RS04460	COG2732	(Barnase) inhibitor
OW521_RS04495	COG3300	MHYT domain
OW521_RS04495	COG5001	Diguanylate cyclase
OW521_RS04550	COG2226	methyltransferase
OW521_RS04555	COG0789	Transcriptional regulator
OW521_RS04580	COG3118	belongs to the thioredoxin family
OW521_RS04615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OW521_RS04625	COG0701	Predicted permease
OW521_RS04645	COG0789	Transcriptional regulator
OW521_RS04655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OW521_RS04690	COG1475	DNA binding
OW521_RS04715	COG0577	efflux transmembrane transporter activity
OW521_RS04720	COG1136	(ABC) transporter
OW521_RS04735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OW521_RS04810	COG0789	Transcriptional regulator
OW521_RS04815	COG0071	Belongs to the small heat shock protein (HSP20) family
OW521_RS04820	COG0484	heat shock protein binding
OW521_RS04850	COG3237	CsbD-like
OW521_RS04920	COG5416	Lipopolysaccharide assembly protein A domain
OW521_RS04930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OW521_RS04975	COG0667	Aldo Keto reductase
OW521_RS04995	COG1309	transcriptional regulator
OW521_RS05015	COG0277	FAD linked oxidase domain protein
OW521_RS05020	COG0277	FAD linked oxidase domain protein
OW521_RS05060	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS05070	COG4974	Belongs to the 'phage' integrase family
OW521_RS05085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OW521_RS05100	COG0297	glycogen (starch) synthase activity
OW521_RS05110	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OW521_RS05140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OW521_RS05155	COG0358	DNA primase activity
OW521_RS05170	COG2197	response regulator
OW521_RS05175	COG4585	Histidine kinase
OW521_RS05180	COG0842	Transport permease protein
OW521_RS05185	COG1131	(ABC) transporter
OW521_RS05195	COG2801	Transposase and inactivated derivatives
OW521_RS05195	COG3415	Transposase
OW521_RS05200	COG0277	FAD linked oxidase domain protein
OW521_RS05210	COG0423	glycine-tRNA ligase activity
OW521_RS05240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OW521_RS05280	COG1940	carbohydrate kinase activity
OW521_RS05290	COG1228	amidohydrolase
OW521_RS05305	COG1486	melibiose metabolic process
OW521_RS05315	COG1063	alcohol dehydrogenase
OW521_RS05325	COG0673	inositol 2-dehydrogenase activity
OW521_RS05340	COG0395	ABC-type sugar transport system, permease component
OW521_RS05345	COG4209	transmembrane transport
OW521_RS05355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OW521_RS05360	COG0154	amidase activity
OW521_RS05365	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OW521_RS05375	COG0251	oxidation-reduction process
OW521_RS05380	COG0456	acetyltransferase
OW521_RS05385	COG0483	inositol monophosphate 1-phosphatase activity
OW521_RS05390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OW521_RS05420	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS05425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OW521_RS05435	COG2801	Transposase and inactivated derivatives
OW521_RS05435	COG3415	Transposase
OW521_RS05445	COG0393	Putative heavy-metal-binding
OW521_RS05450	COG1309	transcriptional regulator
OW521_RS05455	COG2409	Drug exporters of the RND superfamily
OW521_RS05460	COG0424	maF-like protein
OW521_RS05465	COG4770	biotin carboxylase activity
OW521_RS05470	COG0477	Major facilitator Superfamily
OW521_RS05475	COG2223	nitrite transmembrane transporter activity
OW521_RS05480	COG0243	molybdopterin cofactor binding
OW521_RS05550	COG1621	beta-fructofuranosidase activity
OW521_RS05555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OW521_RS05565	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OW521_RS05565	COG2146	nitrite reductase [NAD(P)H] activity
OW521_RS05615	COG0446	pyridine nucleotide-disulphide oxidoreductase
OW521_RS05620	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
OW521_RS05655	COG1988	membrane-bound metal-dependent
OW521_RS05675	COG3415	Transposase
OW521_RS05675	COG2801	Transposase and inactivated derivatives
OW521_RS05680	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OW521_RS05710	COG1215	transferase activity, transferring glycosyl groups
OW521_RS05720	COG3979	chitinase
OW521_RS05730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OW521_RS05745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OW521_RS05765	COG0193	aminoacyl-tRNA hydrolase activity
OW521_RS05770	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
OW521_RS05780	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
OW521_RS05790	COG1309	transcriptional regulator
OW521_RS05800	COG0488	(ABC) transporter
OW521_RS05805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
OW521_RS05810	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OW521_RS05815	COG3583	domain protein
OW521_RS05820	COG0084	hydrolase, TatD family'
OW521_RS05825	COG0714	Associated with various cellular activities
OW521_RS05875	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
OW521_RS05930	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
OW521_RS05935	COG1482	cell wall glycoprotein biosynthetic process
OW521_RS05950	COG1494	fructose-1,6-bisphosphatase
OW521_RS05960	COG0288	reversible hydration of carbon dioxide
OW521_RS05965	COG0114	fumarate hydratase activity
OW521_RS06000	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
OW521_RS06005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OW521_RS06020	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OW521_RS06035	COG3547	Transposase (IS116 IS110 IS902 family)
OW521_RS06050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OW521_RS06050	COG0357	Ribosomal RNA small subunit methyltransferase G
OW521_RS06070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
OW521_RS06085	COG0673	inositol 2-dehydrogenase activity
OW521_RS06100	COG1653	transport
OW521_RS06105	COG1609	Transcriptional regulator
OW521_RS06110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OW521_RS06120	COG0673	inositol 2-dehydrogenase activity
OW521_RS06130	COG0395	ABC-type sugar transport system, permease component
OW521_RS06135	COG1175	transmembrane transport
OW521_RS06145	COG1609	Transcriptional regulator
OW521_RS06155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OW521_RS06170	COG1024	Enoyl-CoA hydratase
OW521_RS06180	COG1024	Enoyl-CoA hydratase
OW521_RS06190	COG0415	Belongs to the DNA photolyase family
OW521_RS06205	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OW521_RS06215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OW521_RS06235	COG1609	Transcriptional regulator
OW521_RS06260	COG0366	Alpha amylase catalytic
OW521_RS06290	COG1302	Protein conserved in bacteria
OW521_RS06320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OW521_RS06325	COG1609	Transcriptional regulator
OW521_RS06340	COG3848	Pyruvate phosphate dikinase
OW521_RS06340	COG0574	Belongs to the PEP-utilizing enzyme family
OW521_RS06360	COG2252	PERMEase
OW521_RS06365	COG0010	Belongs to the arginase family
OW521_RS06385	COG1472	Belongs to the glycosyl hydrolase 3 family
OW521_RS06400	COG0444	Belongs to the ABC transporter superfamily
OW521_RS06420	COG2801	Transposase and inactivated derivatives
OW521_RS06420	COG3415	Transposase
OW521_RS06425	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS06435	COG2186	Transcriptional regulator
OW521_RS06445	COG2376	Dihydroxyacetone kinase
OW521_RS06450	COG0698	ribose 5-phosphate isomerase
OW521_RS06455	COG0149	triose-phosphate isomerase activity
OW521_RS06460	COG1082	Xylose isomerase domain protein TIM barrel
OW521_RS06465	COG2084	Dehydrogenase
OW521_RS06470	COG2902	Dehydrogenase
OW521_RS06490	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
OW521_RS06505	COG1476	TRANSCRIPTIONal
OW521_RS06520	COG1280	lysine exporter protein (LysE YggA)
OW521_RS06535	COG1609	Transcriptional regulator
OW521_RS06540	COG0395	ABC-type sugar transport system, permease component
OW521_RS06545	COG1175	transmembrane transport
OW521_RS06550	COG1653	transport
OW521_RS06560	COG3706	GGDEF domain
OW521_RS06565	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS06590	COG4122	O-methyltransferase activity
OW521_RS06630	COG2733	membrane
OW521_RS06635	COG1984	allophanate hydrolase subunit 2
OW521_RS06640	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
OW521_RS06645	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OW521_RS06665	COG1819	glycosyl
OW521_RS06690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OW521_RS06710	COG0395	ABC-type sugar transport system, permease component
OW521_RS06715	COG1175	transmembrane transport
OW521_RS06725	COG1609	Transcriptional regulator
OW521_RS06750	COG1349	DNA-binding transcription factor activity
OW521_RS06760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OW521_RS06760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OW521_RS06760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OW521_RS06765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OW521_RS06785	COG3237	CsbD-like
OW521_RS06800	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
OW521_RS06820	COG2890	protein-(glutamine-N5) methyltransferase activity
OW521_RS06825	COG0477	Major facilitator Superfamily
OW521_RS06835	COG0745	RESPONSE REGULATOR receiver
OW521_RS06840	COG5002	protein histidine kinase activity
OW521_RS06845	COG0346	lactoylglutathione lyase activity
OW521_RS06855	COG0542	response to heat
OW521_RS06895	COG0673	inositol 2-dehydrogenase activity
OW521_RS06900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OW521_RS06905	COG1609	Transcriptional regulator
OW521_RS06910	COG0673	inositol 2-dehydrogenase activity
OW521_RS06920	COG3962	Belongs to the TPP enzyme family
OW521_RS06925	COG1012	belongs to the aldehyde dehydrogenase family
OW521_RS06935	COG1172	Belongs to the binding-protein-dependent transport system permease family
OW521_RS07015	COG2610	gluconate transmembrane transporter activity
OW521_RS07020	COG2084	Dehydrogenase
OW521_RS07030	COG2267	carboxylic ester hydrolase activity
OW521_RS07035	COG2186	Transcriptional regulator
OW521_RS07040	COG3360	Dodecin
OW521_RS07065	COG0667	Aldo Keto reductase
OW521_RS07075	COG0656	L-ascorbic acid biosynthetic process
OW521_RS07090	COG1796	DNA polymerase
OW521_RS07090	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
OW521_RS07095	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
OW521_RS07100	COG0829	nickel cation binding
OW521_RS07105	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
OW521_RS07110	COG0830	nickel cation binding
OW521_RS07115	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
OW521_RS07120	COG0804	urea catabolic process
OW521_RS07125	COG0832	Belongs to the urease beta subunit family
OW521_RS07130	COG0831	urea catabolic process
OW521_RS07140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_RS07160	COG0306	phosphate transporter
OW521_RS07165	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OW521_RS07200	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OW521_RS07205	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
OW521_RS07220	COG2226	methyltransferase
OW521_RS07255	COG1461	Dihydroxyacetone kinase
OW521_RS07260	COG2376	Dihydroxyacetone kinase
OW521_RS07265	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
OW521_RS07270	COG1506	peptidase
OW521_RS07270	COG0823	Involved in the tonB-independent uptake of proteins
OW521_RS07290	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
OW521_RS07295	COG0596	Alpha beta hydrolase
OW521_RS07350	COG2814	Major facilitator Superfamily
OW521_RS07355	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
OW521_RS07385	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OW521_RS07390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OW521_RS07395	COG0302	gtp cyclohydrolase
OW521_RS07400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OW521_RS07410	COG0037	tRNA processing
OW521_RS07420	COG2027	D-alanyl-D-alanine carboxypeptidase
OW521_RS07440	COG0561	phosphatase activity
OW521_RS07450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
OW521_RS07455	COG1597	lipid kinase activity
OW521_RS07465	COG0077	Prephenate dehydratase
OW521_RS07470	COG0425	Belongs to the sulfur carrier protein TusA family
OW521_RS07470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OW521_RS07475	COG3340	Belongs to the peptidase S51 family
OW521_RS07480	COG0154	amidase activity
OW521_RS07485	COG3104	oligopeptide transport
OW521_RS07505	COG0778	Nitroreductase
OW521_RS07510	COG2233	PERMEase
OW521_RS07515	COG1610	YqeY-like protein
OW521_RS07525	COG1929	Belongs to the glycerate kinase type-1 family
OW521_RS07535	COG4941	Belongs to the sigma-70 factor family
OW521_RS07540	COG0584	glycerophosphoryl diester phosphodiesterase
OW521_RS07565	COG0561	phosphatase activity
OW521_RS07605	COG1609	Transcriptional regulator
OW521_RS07630	COG3585	molybdate ion transport
OW521_RS07650	COG4770	biotin carboxylase activity
OW521_RS07655	COG1984	allophanate hydrolase subunit 2
OW521_RS07660	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OW521_RS07685	COG1716	ATPase activity
OW521_RS07700	COG0768	penicillin binding
OW521_RS07705	COG0515	serine threonine protein kinase
OW521_RS07710	COG0515	serine threonine protein kinase
OW521_RS07710	COG2815	serine threonine protein kinase
OW521_RS07720	COG3764	Sortase (surface protein transpeptidase)
OW521_RS07735	COG1595	DNA-templated transcription, initiation
OW521_RS07740	COG2169	Transcriptional regulator
OW521_RS07740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OW521_RS07750	COG2818	Glycosylase
OW521_RS07755	COG0640	Transcriptional regulator
OW521_RS07790	COG1331	Highly conserved protein containing a thioredoxin domain
OW521_RS07800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
OW521_RS07810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OW521_RS07815	COG2801	Transposase and inactivated derivatives
OW521_RS07815	COG3415	Transposase
OW521_RS07825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OW521_RS07835	COG2017	converts alpha-aldose to the beta-anomer
OW521_RS07845	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
OW521_RS07850	COG0183	Belongs to the thiolase family
OW521_RS07860	COG0559	Belongs to the binding-protein-dependent transport system permease family
OW521_RS07895	COG1252	NADH dehydrogenase
OW521_RS07920	COG0148	phosphopyruvate hydratase activity
OW521_RS07925	COG3956	TIGRFAM MazG family protein
OW521_RS07930	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
OW521_RS07955	COG1079	Belongs to the binding-protein-dependent transport system permease family
OW521_RS07960	COG4603	Belongs to the binding-protein-dependent transport system permease family
OW521_RS07965	COG3845	ABC transporter
OW521_RS07970	COG1744	ABC transporter substrate-binding protein PnrA-like
OW521_RS07975	COG2130	NADP-dependent
OW521_RS07980	COG1764	response to oxidative stress
OW521_RS07985	COG1846	Transcriptional regulator
OW521_RS07990	COG1473	amidohydrolase
OW521_RS07990	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
OW521_RS08000	COG2009	succinate dehydrogenase
OW521_RS08015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OW521_RS08035	COG0180	Tryptophanyl-tRNA synthetase
OW521_RS08060	COG1131	(ABC) transporter
OW521_RS08070	COG2197	response regulator
OW521_RS08075	COG4585	Histidine kinase
OW521_RS08080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
OW521_RS08085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OW521_RS08110	COG0531	amino acid
OW521_RS08115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OW521_RS08135	COG1122	ATPase activity
OW521_RS08180	COG4213	ABC transporter substrate-binding protein
OW521_RS08185	COG3639	organic phosphonate transmembrane transporter activity
OW521_RS08190	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
OW521_RS08195	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
OW521_RS08200	COG0673	inositol 2-dehydrogenase activity
OW521_RS08225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OW521_RS08240	COG2838	Isocitrate dehydrogenase
OW521_RS08250	COG0138	bifunctional purine biosynthesis protein purh
OW521_RS08260	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
OW521_RS08265	COG2271	Major facilitator Superfamily
OW521_RS08295	COG0179	Fumarylacetoacetate (FAA) hydrolase
OW521_RS08310	COG2814	Major facilitator Superfamily
OW521_RS08315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OW521_RS08320	COG2268	Band 7 protein
OW521_RS08340	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
OW521_RS08370	COG1116	anion transmembrane transporter activity
OW521_RS08445	COG0492	ferredoxin-NADP+ reductase activity
OW521_RS08560	COG0531	amino acid
OW521_RS08575	COG0477	Major facilitator Superfamily
OW521_RS08585	COG0667	Aldo Keto reductase
OW521_RS08590	COG1501	Belongs to the glycosyl hydrolase 31 family
OW521_RS08595	COG3387	PFAM Glycoside hydrolase 15-related
OW521_RS08605	COG0395	ABC-type sugar transport system, permease component
OW521_RS08610	COG1175	transmembrane transport
OW521_RS08615	COG1846	Transcriptional regulator
OW521_RS08615	COG1940	carbohydrate kinase activity
OW521_RS08620	COG1309	transcriptional regulator
OW521_RS08655	COG0640	Transcriptional regulator
OW521_RS08670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
OW521_RS08705	COG2188	Transcriptional regulator
OW521_RS08725	COG0149	triose-phosphate isomerase activity
OW521_RS08730	COG2271	Major facilitator Superfamily
OW521_RS08735	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS08740	COG1250	3-hydroxyacyl-CoA dehydrogenase
OW521_RS08745	COG0698	ribose 5-phosphate isomerase
OW521_RS08750	COG2376	Dihydroxyacetone kinase
OW521_RS08765	COG1902	pentaerythritol trinitrate reductase activity
OW521_RS08780	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
OW521_RS08785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OW521_RS08795	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
OW521_RS08830	COG1401	restriction endodeoxyribonuclease activity
OW521_RS08845	COG3142	Participates in the control of copper homeostasis
OW521_RS08865	COG0477	Major facilitator Superfamily
OW521_RS08875	COG0028	Belongs to the TPP enzyme family
OW521_RS08900	COG1396	sequence-specific DNA binding
OW521_RS08955	COG1760	l-serine dehydratase
OW521_RS08980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OW521_RS09005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OW521_RS09030	COG0517	IMP dehydrogenase activity
OW521_RS09030	COG4175	Glycine betaine
OW521_RS09035	COG4176	ABC-type proline glycine betaine transport system permease component
OW521_RS09045	COG0477	Major facilitator Superfamily
OW521_RS09065	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
OW521_RS09080	COG2188	Transcriptional regulator
OW521_RS09085	COG3718	enzyme involved in inositol metabolism
OW521_RS09090	COG0673	inositol 2-dehydrogenase activity
OW521_RS09100	COG0673	inositol 2-dehydrogenase activity
OW521_RS09105	COG0673	inositol 2-dehydrogenase activity
OW521_RS09110	COG0673	inositol 2-dehydrogenase activity
OW521_RS09130	COG1609	Transcriptional regulator
OW521_RS09150	COG0659	secondary active sulfate transmembrane transporter activity
OW521_RS09155	COG1082	Xylose isomerase domain protein TIM barrel
OW521_RS09160	COG0673	inositol 2-dehydrogenase activity
OW521_RS09175	COG3962	Belongs to the TPP enzyme family
OW521_RS09190	COG1942	4-Oxalocrotonate Tautomerase
OW521_RS09200	COG0045	succinate-CoA ligase (ADP-forming) activity
OW521_RS09210	COG0483	inositol monophosphate 1-phosphatase activity
OW521_RS09260	COG0494	nUDIX hydrolase
OW521_RS09280	COG1132	(ABC) transporter
OW521_RS09285	COG0488	(ABC) transporter
OW521_RS09300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OW521_RS09305	COG0765	amino acid transport
OW521_RS09310	COG1126	abc transporter atp-binding protein
OW521_RS09320	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OW521_RS09340	COG0746	molybdenum cofactor guanylyltransferase activity
OW521_RS09355	COG0739	heme binding
OW521_RS09370	COG2814	Major facilitator Superfamily
OW521_RS09380	COG1278	Cold shock
OW521_RS09405	COG0583	DNA-binding transcription factor activity
OW521_RS09415	COG0745	RESPONSE REGULATOR receiver
OW521_RS09430	COG0328	RNA-DNA hybrid ribonuclease activity
OW521_RS09435	COG0459	protein refolding
OW521_RS09480	COG3591	Belongs to the peptidase S1B family
OW521_RS09480	COG1864	DNA RNA non-specific endonuclease
OW521_RS09490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OW521_RS09495	COG0509	glycine decarboxylation via glycine cleavage system
OW521_RS09500	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OW521_RS09505	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OW521_RS09505	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OW521_RS09515	COG0477	Major facilitator Superfamily
OW521_RS09545	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
OW521_RS09555	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OW521_RS09560	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OW521_RS09570	COG1987	bacterial-type flagellum assembly
OW521_RS09575	COG1338	Plays a role in the flagellum-specific transport system
OW521_RS09625	COG1360	Flagellar Motor Protein
OW521_RS09630	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
OW521_RS09640	COG0390	transport system, permease component
OW521_RS09665	COG3842	ATPase activity
OW521_RS09690	COG2205	protein histidine kinase activity
OW521_RS09705	COG0671	phosphoesterase, PA-phosphatase related
OW521_RS09725	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
OW521_RS09730	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
OW521_RS09745	COG0477	Major facilitator Superfamily
OW521_RS09765	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
OW521_RS09785	COG1157	protein secretion by the type III secretion system
OW521_RS09795	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OW521_RS09800	COG1766	The M ring may be actively involved in energy transduction
OW521_RS09805	COG1677	Flagellar hook-basal body complex protein FliE
OW521_RS09815	COG1815	bacterial-type flagellum-dependent cell motility
OW521_RS09835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OW521_RS09845	COG1256	bacterial-type flagellum assembly
OW521_RS09845	COG4786	Flagellar basal body rod
OW521_RS09850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OW521_RS09855	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
OW521_RS09895	COG0483	inositol monophosphate 1-phosphatase activity
OW521_RS09900	COG3842	ATPase activity
OW521_RS09905	COG1177	transmembrane transport
OW521_RS09935	COG0640	Transcriptional regulator
OW521_RS09945	COG4565	transcriptional regulatory protein
OW521_RS09950	COG3290	protein histidine kinase activity
OW521_RS09955	COG1116	anion transmembrane transporter activity
OW521_RS09970	COG0154	amidase activity
OW521_RS09980	COG0402	S-adenosylhomocysteine deaminase activity
OW521_RS10025	COG1335	isochorismatase
OW521_RS10030	COG0747	negative chemotaxis
OW521_RS10055	COG0444	Belongs to the ABC transporter superfamily
OW521_RS10065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OW521_RS10075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OW521_RS10080	COG0667	Aldo Keto reductase
OW521_RS10100	COG0395	ABC-type sugar transport system, permease component
OW521_RS10105	COG1175	transmembrane transport
OW521_RS10115	COG0366	Alpha amylase catalytic
OW521_RS10120	COG1846	Transcriptional regulator
OW521_RS10120	COG1940	carbohydrate kinase activity
OW521_RS10130	COG2203	Gaf domain
OW521_RS10130	COG3706	GGDEF domain
OW521_RS10130	COG4251	negative regulation of phosphorylation
OW521_RS10130	COG5001	Diguanylate cyclase
OW521_RS10135	COG2199	diguanylate cyclase activity
OW521_RS10155	COG3239	Fatty acid desaturase
OW521_RS10165	COG2160	L-arabinose isomerase activity
OW521_RS10180	COG1609	Transcriptional regulator
OW521_RS10215	COG0673	inositol 2-dehydrogenase activity
OW521_RS10220	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS10235	COG1175	transmembrane transport
OW521_RS10240	COG3386	PFAM SMP-30 Gluconolaconase
OW521_RS10245	COG4948	Mandelate Racemase Muconate Lactonizing
OW521_RS10285	COG0667	Aldo Keto reductase
OW521_RS10290	COG1621	beta-fructofuranosidase activity
OW521_RS10305	COG0395	ABC-type sugar transport system, permease component
OW521_RS10310	COG4209	transmembrane transport
OW521_RS10335	COG0395	ABC-type sugar transport system, permease component
OW521_RS10350	COG1609	Transcriptional regulator
OW521_RS10355	COG1621	beta-fructofuranosidase activity
OW521_RS10390	COG3842	ATPase activity
OW521_RS10430	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OW521_RS10435	COG0366	Alpha amylase catalytic
OW521_RS10440	COG0366	Alpha amylase catalytic
OW521_RS10470	COG0215	cysteine-tRNA ligase activity
OW521_RS10475	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
OW521_RS10480	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
OW521_RS10500	COG5002	protein histidine kinase activity
OW521_RS10510	COG0588	phosphoglycerate mutase activity
OW521_RS10530	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
OW521_RS10535	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OW521_RS10600	COG0656	L-ascorbic acid biosynthetic process
OW521_RS10615	COG2153	protein acetylation
OW521_RS10625	COG0604	alcohol dehydrogenase
OW521_RS10640	COG2146	nitrite reductase [NAD(P)H] activity
OW521_RS10640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OW521_RS10650	COG1968	undecaprenyl-diphosphatase activity
OW521_RS10665	COG1505	serine-type exopeptidase activity
OW521_RS10675	COG2814	Major facilitator Superfamily
OW521_RS10680	COG0514	ATP-dependent DNA helicase (RecQ)
OW521_RS10700	COG1017	nitric oxide dioxygenase activity
OW521_RS10700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OW521_RS10710	COG0574	Belongs to the PEP-utilizing enzyme family
OW521_RS10710	COG3848	Pyruvate phosphate dikinase
OW521_RS10715	COG2814	Major facilitator Superfamily
OW521_RS10720	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
OW521_RS10730	COG2188	Transcriptional regulator
OW521_RS10740	COG0601	transmembrane transport
OW521_RS10745	COG0444	Belongs to the ABC transporter superfamily
OW521_RS10750	COG4608	Belongs to the ABC transporter superfamily
OW521_RS10760	COG1940	carbohydrate kinase activity
OW521_RS10765	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
OW521_RS10780	COG1511	domain protein
OW521_RS10785	COG1309	transcriptional regulator
OW521_RS10795	COG0697	spore germination
OW521_RS10800	COG0583	DNA-binding transcription factor activity
OW521_RS10820	COG0745	RESPONSE REGULATOR receiver
OW521_RS10825	COG2205	protein histidine kinase activity
OW521_RS10840	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OW521_RS10840	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OW521_RS10845	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OW521_RS10880	COG0363	glucosamine-6-phosphate deaminase activity
OW521_RS10885	COG4821	SIS domain
OW521_RS10890	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OW521_RS10900	COG1609	Transcriptional regulator
OW521_RS10905	COG0477	Major facilitator Superfamily
OW521_RS10910	COG1309	transcriptional regulator
OW521_RS10915	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
OW521_RS10930	COG1254	Belongs to the acylphosphatase family
OW521_RS10955	COG4974	Belongs to the 'phage' integrase family
OW521_RS10975	COG1621	beta-fructofuranosidase activity
OW521_RS10985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OW521_RS10990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
OW521_RS11030	COG1070	Carbohydrate kinase
OW521_RS11035	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS11035	COG3347	Dehydrogenase
OW521_RS11070	COG0475	glutathione-regulated potassium exporter activity
OW521_RS11070	COG0569	domain protein
OW521_RS11090	COG1201	RNA secondary structure unwinding
OW521_RS11095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OW521_RS11100	COG2364	Membrane
OW521_RS11130	COG0564	pseudouridine synthase activity
OW521_RS11160	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
OW521_RS11170	COG1215	transferase activity, transferring glycosyl groups
OW521_RS11180	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
OW521_RS11200	COG0673	inositol 2-dehydrogenase activity
OW521_RS11215	COG0673	inositol 2-dehydrogenase activity
OW521_RS11220	COG1609	Transcriptional regulator
OW521_RS11225	COG0477	Major facilitator Superfamily
OW521_RS11230	COG3254	rhamnose metabolic process
OW521_RS11235	COG1960	acyl-CoA dehydrogenase activity
OW521_RS11280	COG0343	queuine tRNA-ribosyltransferase activity
OW521_RS11300	COG0477	Major facilitator Superfamily
OW521_RS11320	COG1476	TRANSCRIPTIONal
OW521_RS11330	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OW521_RS11365	COG0395	ABC-type sugar transport system, permease component
OW521_RS11380	COG0673	inositol 2-dehydrogenase activity
OW521_RS11390	COG0477	Major facilitator Superfamily
OW521_RS11405	COG1309	transcriptional regulator
OW521_RS11430	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OW521_RS11435	COG0386	Belongs to the glutathione peroxidase family
OW521_RS11450	COG1846	Transcriptional regulator
OW521_RS11465	COG1012	belongs to the aldehyde dehydrogenase family
OW521_RS11480	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OW521_RS11480	COG3323	Protein of unknown function (DUF1653)
OW521_RS11495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OW521_RS11505	COG1131	(ABC) transporter
OW521_RS11525	COG1846	Transcriptional regulator
OW521_RS11580	COG0047	phosphoribosylformylglycinamidine synthase activity
OW521_RS11585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OW521_RS11610	COG0395	ABC-type sugar transport system, permease component
OW521_RS11615	COG1175	transmembrane transport
OW521_RS11620	COG1653	transport
OW521_RS11630	COG2315	Protein conserved in bacteria
OW521_RS11640	COG1832	CoA-binding protein
OW521_RS11675	COG1215	transferase activity, transferring glycosyl groups
OW521_RS11700	COG3266	domain, Protein
OW521_RS11705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OW521_RS11710	COG0187	DNA topoisomerase II activity
OW521_RS11715	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
OW521_RS11720	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OW521_RS11725	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
OW521_RS11730	COG0592	DNA-directed DNA polymerase activity
OW521_RS11735	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
OW521_RS11740	COG0230	Belongs to the bacterial ribosomal protein bL34 family
OW521_RS11745	COG0594	ribonuclease P activity
OW521_RS11750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
OW521_RS11755	COG0706	membrane insertase activity
OW521_RS11765	COG0357	Ribosomal RNA small subunit methyltransferase G
OW521_RS11770	COG1192	Involved in chromosome partitioning
OW521_RS11795	COG3118	belongs to the thioredoxin family
OW521_RS11800	COG0492	ferredoxin-NADP+ reductase activity
OW521_RS11820	COG0617	tRNA 3'-terminal CCA addition
OW521_RS11825	COG0406	alpha-ribazole phosphatase activity
OW521_RS11845	COG2910	NAD(P)H-binding
OW521_RS11850	COG1733	regulation of RNA biosynthetic process
OW521_RS11865	COG4585	Histidine kinase
OW521_RS11870	COG2197	response regulator
OW521_RS11875	COG0768	penicillin binding
OW521_RS11885	COG1309	transcriptional regulator
OW521_RS11890	COG0488	(ABC) transporter
OW521_RS11900	COG3226	Transcriptional regulator
OW521_RS11905	COG0738	Major facilitator superfamily
OW521_RS11915	COG1136	(ABC) transporter
OW521_RS11915	COG0577	efflux transmembrane transporter activity
OW521_RS11920	COG1136	(ABC) transporter
OW521_RS11935	COG1131	(ABC) transporter
OW521_RS11945	COG4585	Histidine kinase
OW521_RS11950	COG2197	response regulator
OW521_RS11955	COG1362	aminopeptidase activity
OW521_RS11965	COG1742	UPF0060 membrane protein
OW521_RS11970	COG0360	Binds together with S18 to 16S ribosomal RNA
OW521_RS11980	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
OW521_RS11985	COG0359	binds to the 23S rRNA
OW521_RS12010	COG0305	Participates in initiation and elongation during chromosome replication
OW521_RS12015	COG1607	acyl-coa hydrolase
OW521_RS12020	COG2259	Doxx family
OW521_RS12065	COG1937	Protein conserved in bacteria
OW521_RS12080	COG0395	ABC-type sugar transport system, permease component
OW521_RS12085	COG3525	Glycosyl hydrolase, family 20, catalytic domain
OW521_RS12090	COG1414	Transcriptional regulator
OW521_RS12105	COG1414	Transcriptional regulator
OW521_RS12120	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
OW521_RS12130	COG2610	gluconate transmembrane transporter activity
OW521_RS12145	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
OW521_RS12155	COG0477	Major facilitator Superfamily
OW521_RS12160	COG1414	Transcriptional regulator
OW521_RS12165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OW521_RS12170	COG1082	Xylose isomerase domain protein TIM barrel
OW521_RS12170	COG3185	4-Hydroxyphenylpyruvate dioxygenase
OW521_RS12175	COG3485	protocatechuate 3,4-dioxygenase
OW521_RS12195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OW521_RS12200	COG0183	Belongs to the thiolase family
OW521_RS12210	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OW521_RS12235	COG1011	Hydrolase
OW521_RS12355	COG1278	Cold shock
OW521_RS12380	COG2271	Major facilitator Superfamily
OW521_RS12385	COG0506	proline dehydrogenase activity
OW521_RS12395	COG1970	mechanosensitive ion channel activity
OW521_RS12425	COG2017	converts alpha-aldose to the beta-anomer
OW521_RS12430	COG1940	carbohydrate kinase activity
OW521_RS12435	COG0277	FAD linked oxidase domain protein
OW521_RS12440	COG2115	Belongs to the xylose isomerase family
OW521_RS12445	COG1070	Carbohydrate kinase
OW521_RS12490	COG0673	inositol 2-dehydrogenase activity
OW521_RS12500	COG1175	transmembrane transport
OW521_RS12505	COG1653	transport
OW521_RS12515	COG2059	Chromate
OW521_RS12550	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
OW521_RS12555	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
OW521_RS12560	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
OW521_RS12585	COG4221	oxidoreductase activity
OW521_RS12615	COG0596	Alpha beta hydrolase
OW521_RS12630	COG1802	Transcriptional regulator
OW521_RS12645	COG3971	2-oxopent-4-enoate hydratase activity
OW521_RS12660	COG0436	Aminotransferase
OW521_RS12665	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OW521_RS12675	COG0583	DNA-binding transcription factor activity
OW521_RS12680	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OW521_RS12685	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
OW521_RS12690	COG1984	allophanate hydrolase subunit 2
OW521_RS12695	COG0477	Major facilitator Superfamily
OW521_RS12700	COG4221	oxidoreductase activity
OW521_RS12705	COG1607	acyl-coa hydrolase
OW521_RS12725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OW521_RS12740	COG1950	PFAM Membrane protein of
OW521_RS12745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OW521_RS12755	COG0022	dehydrogenase e1 component
OW521_RS12760	COG0508	dehydrogenase complex catalyzes the overall conversion of
OW521_RS12780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OW521_RS12805	COG1309	transcriptional regulator
OW521_RS12810	COG0673	inositol 2-dehydrogenase activity
OW521_RS12830	COG0686	Belongs to the AlaDH PNT family
OW521_RS12845	COG2072	flavoprotein involved in K transport
OW521_RS12860	COG1309	transcriptional regulator
OW521_RS12865	COG1960	acyl-CoA dehydrogenase activity
OW521_RS12875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OW521_RS12880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OW521_RS12890	COG2213	PTS system mannitol-specific
OW521_RS12890	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OW521_RS12895	COG0246	Mannitol dehydrogenase
OW521_RS12900	COG1846	Transcriptional regulator
OW521_RS12915	COG1846	Transcriptional regulator
OW521_RS12920	COG2814	Major facilitator Superfamily
OW521_RS12925	COG0477	Major facilitator Superfamily
OW521_RS12930	COG0477	Major facilitator Superfamily
OW521_RS12935	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OW521_RS12945	COG1309	transcriptional regulator
OW521_RS12950	COG0281	malic enzyme
OW521_RS12970	COG2197	response regulator
OW521_RS12990	COG1280	lysine exporter protein (LysE YggA)
OW521_RS12995	COG1522	sequence-specific DNA binding
OW521_RS13020	COG0477	Major facilitator Superfamily
OW521_RS13050	COG0436	Aminotransferase
OW521_RS13060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OW521_RS13070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OW521_RS13100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OW521_RS13105	COG0179	Fumarylacetoacetate (FAA) hydrolase
OW521_RS13115	COG1027	Aspartate ammonia-lyase
OW521_RS13125	COG2186	Transcriptional regulator
OW521_RS13160	COG4154	Belongs to the RbsD FucU family
OW521_RS13165	COG1414	Transcriptional regulator
OW521_RS13175	COG3012	SEC-C Motif Domain Protein
OW521_RS13245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OW521_RS13250	COG0227	Belongs to the bacterial ribosomal protein bL28 family
OW521_RS13255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OW521_RS13260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OW521_RS13280	COG0776	regulation of translation
OW521_RS13305	COG2318	DinB family
OW521_RS13330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OW521_RS13335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OW521_RS13345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OW521_RS13350	COG3387	PFAM Glycoside hydrolase 15-related
OW521_RS13360	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
OW521_RS13370	COG1309	transcriptional regulator
OW521_RS13375	COG0583	DNA-binding transcription factor activity
OW521_RS13405	COG0717	Belongs to the dCTP deaminase family
OW521_RS13410	COG0475	glutathione-regulated potassium exporter activity
OW521_RS13420	COG0363	glucosamine-6-phosphate deaminase activity
OW521_RS13425	COG1472	Belongs to the glycosyl hydrolase 3 family
OW521_RS13440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OW521_RS13440	COG2111	Na H antiporter
OW521_RS13445	COG1006	Multisubunit Na H antiporter MnhC subunit
OW521_RS13450	COG0651	ATP synthesis coupled electron transport
OW521_RS13460	COG2212	antiporter activity
OW521_RS13465	COG1320	monovalent cation:proton antiporter activity
OW521_RS13480	COG4721	ABC-type cobalt transport system, permease component
OW521_RS13490	COG1122	ATPase activity
OW521_RS13500	COG2801	Transposase and inactivated derivatives
OW521_RS13500	COG3415	Transposase
OW521_RS13510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OW521_RS13520	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
OW521_RS13555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OW521_RS13575	COG1953	Uracil, thiamine, allantoin
OW521_RS13585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OW521_RS13590	COG3559	Exporter of polyketide antibiotics
OW521_RS13595	COG1131	(ABC) transporter
OW521_RS13600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OW521_RS13605	COG0477	Major facilitator Superfamily
OW521_RS13610	COG1957	nucleoside hydrolase
OW521_RS13615	COG1609	Transcriptional regulator
OW521_RS13620	COG1280	lysine exporter protein (LysE YggA)
OW521_RS13640	COG4941	Belongs to the sigma-70 factor family
OW521_RS13645	COG3795	YCII-related domain
OW521_RS13650	COG2226	methyltransferase
OW521_RS13735	COG3739	integral membrane protein
OW521_RS13740	COG0443	Heat shock 70 kDa protein
OW521_RS13745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OW521_RS13750	COG0484	heat shock protein binding
OW521_RS13755	COG0789	Transcriptional regulator
OW521_RS13790	COG0251	oxidation-reduction process
OW521_RS13795	COG1113	amino acid transport
OW521_RS13805	COG3177	Filamentation induced by cAMP protein fic
OW521_RS13810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
OW521_RS13840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OW521_RS13850	COG1846	Transcriptional regulator
OW521_RS13855	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
OW521_RS13880	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS13890	COG2267	carboxylic ester hydrolase activity
OW521_RS13910	COG1012	belongs to the aldehyde dehydrogenase family
OW521_RS13915	COG2271	Major facilitator Superfamily
OW521_RS13920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OW521_RS13925	COG2807	transmembrane transport
OW521_RS13930	COG0477	Major facilitator Superfamily
OW521_RS13935	COG1473	amidohydrolase
OW521_RS13975	COG0667	Aldo Keto reductase
OW521_RS13995	COG0135	phosphoribosylanthranilate isomerase activity
OW521_RS14020	COG3304	Inner membrane component domain
OW521_RS14025	COG0028	Belongs to the TPP enzyme family
OW521_RS14060	COG0542	response to heat
OW521_RS14075	COG0640	Transcriptional regulator
OW521_RS14090	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
OW521_RS14125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OW521_RS14130	COG0765	amino acid transport
OW521_RS14140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OW521_RS14175	COG0765	amino acid transport
OW521_RS14205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OW521_RS14210	COG1929	Belongs to the glycerate kinase type-1 family
OW521_RS14215	COG3960	tartronate-semialdehyde synthase activity
OW521_RS14220	COG2084	Dehydrogenase
OW521_RS14225	COG3622	Belongs to the hyi family
OW521_RS14240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OW521_RS14245	COG1454	alcohol dehydrogenase
OW521_RS14315	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
OW521_RS14360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OW521_RS14365	COG1228	amidohydrolase
OW521_RS14370	COG1609	Transcriptional regulator
OW521_RS14380	COG1178	ABC-type Fe3 transport system permease component
OW521_RS14385	COG3842	ATPase activity
OW521_RS14435	COG0395	ABC-type sugar transport system, permease component
OW521_RS14440	COG1175	transmembrane transport
OW521_RS14445	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OW521_RS14460	COG3842	ATPase activity
OW521_RS14465	COG1737	Transcriptional regulator
OW521_RS14475	COG2267	carboxylic ester hydrolase activity
OW521_RS14520	COG0698	ribose 5-phosphate isomerase
OW521_RS14525	COG2376	Dihydroxyacetone kinase
OW521_RS14530	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS14535	COG1082	Xylose isomerase domain protein TIM barrel
OW521_RS14540	COG0477	Major facilitator Superfamily
OW521_RS14545	COG3959	Transketolase, thiamine diphosphate binding domain
OW521_RS14550	COG3958	Transketolase
OW521_RS14610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OW521_RS14645	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS14660	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS14705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OW521_RS14705	COG4499	WXG100 protein secretion system (Wss), protein YukC
OW521_RS14715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OW521_RS14720	COG0563	adenylate kinase activity
OW521_RS14725	COG3387	PFAM Glycoside hydrolase 15-related
OW521_RS14730	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
OW521_RS14740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OW521_RS14765	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OW521_RS14770	COG3257	ureidoglycine aminohydrolase activity
OW521_RS14780	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OW521_RS14790	COG1414	Transcriptional regulator
OW521_RS14795	COG2233	PERMEase
OW521_RS14820	COG0590	tRNA wobble adenosine to inosine editing
OW521_RS14825	COG2252	PERMEase
OW521_RS14830	COG3608	succinylglutamate desuccinylase aspartoacylase
OW521_RS14830	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
OW521_RS14850	COG0741	lytic transglycosylase activity
OW521_RS14850	COG1196	nuclear chromosome segregation
OW521_RS14850	COG0739	heme binding
OW521_RS14865	COG2271	Major facilitator Superfamily
OW521_RS14875	COG3340	Belongs to the peptidase S51 family
OW521_RS14885	COG4126	flavin adenine dinucleotide binding
OW521_RS14985	COG1953	Uracil, thiamine, allantoin
OW521_RS15000	COG2066	Belongs to the glutaminase family
OW521_RS15005	COG1301	dicarboxylic acid transport
OW521_RS15035	COG0151	Belongs to the GarS family
OW521_RS15040	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
OW521_RS15060	COG1132	(ABC) transporter
OW521_RS15065	COG1132	(ABC) transporter
OW521_RS15070	COG1408	metallophosphoesterase
OW521_RS15075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OW521_RS15110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
OW521_RS15125	COG0395	ABC-type sugar transport system, permease component
OW521_RS15130	COG1175	transmembrane transport
OW521_RS15140	COG1609	Transcriptional regulator
OW521_RS15145	COG1349	DNA-binding transcription factor activity
OW521_RS15155	COG0395	ABC-type sugar transport system, permease component
OW521_RS15160	COG1175	transmembrane transport
OW521_RS15170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OW521_RS15200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OW521_RS15200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OW521_RS15240	COG1111	helicase
OW521_RS15240	COG1205	dead DEAH box helicase
OW521_RS15250	COG1054	Belongs to the UPF0176 family
OW521_RS15275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OW521_RS15275	COG1754	DNA topoisomerase type I activity
OW521_RS15290	COG0248	Ppx GppA phosphatase
OW521_RS15295	COG1082	Xylose isomerase domain protein TIM barrel
OW521_RS15300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
OW521_RS15305	COG0598	Magnesium transport protein CorA
OW521_RS15310	COG0569	domain protein
OW521_RS15315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OW521_RS15320	COG0123	including yeast histone deacetylase and acetoin utilization protein
OW521_RS15325	COG0640	Transcriptional regulator
OW521_RS15340	COG1609	Transcriptional regulator
OW521_RS15345	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OW521_RS15370	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
OW521_RS15390	COG0406	alpha-ribazole phosphatase activity
OW521_RS15400	COG0785	Cytochrome C biogenesis protein
OW521_RS15410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OW521_RS15435	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
OW521_RS15470	COG0183	Belongs to the thiolase family
OW521_RS15475	COG1024	Enoyl-CoA hydratase
OW521_RS15480	COG1250	3-hydroxyacyl-CoA dehydrogenase
OW521_RS15495	COG0673	inositol 2-dehydrogenase activity
OW521_RS15505	COG0395	ABC-type sugar transport system, permease component
OW521_RS15515	COG2182	Extracellular solute-binding protein
OW521_RS15520	COG1609	Transcriptional regulator
OW521_RS15540	COG1012	belongs to the aldehyde dehydrogenase family
OW521_RS15540	COG2030	dehydratase
OW521_RS15565	COG2050	protein possibly involved in aromatic compounds catabolism
OW521_RS15585	COG0747	negative chemotaxis
OW521_RS15595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OW521_RS15615	COG0745	RESPONSE REGULATOR receiver
OW521_RS15625	COG5002	protein histidine kinase activity
OW521_RS15635	COG1316	TRANSCRIPTIONal
OW521_RS15695	COG2894	cell division
OW521_RS15720	COG0745	RESPONSE REGULATOR receiver
OW521_RS15735	COG3396	Phenylacetate-CoA oxygenase
OW521_RS15740	COG3460	Phenylacetate-CoA oxygenase
OW521_RS15745	COG3396	Phenylacetate-CoA oxygenase
OW521_RS15750	COG2151	metal-sulfur cluster biosynthetic enzyme
OW521_RS15755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OW521_RS15775	COG5001	Diguanylate cyclase
OW521_RS15785	COG1316	TRANSCRIPTIONal
OW521_RS15810	COG0640	Transcriptional regulator
OW521_RS15815	COG1316	TRANSCRIPTIONal
OW521_RS15820	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OW521_RS15825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OW521_RS15830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OW521_RS15850	COG0489	protein tyrosine kinase activity
OW521_RS15855	COG0438	transferase activity, transferring glycosyl groups
OW521_RS15925	COG0022	dehydrogenase e1 component
OW521_RS15930	COG0508	dehydrogenase complex catalyzes the overall conversion of
OW521_RS15940	COG3344	reverse transcriptase
OW521_RS15995	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
OW521_RS16000	COG0562	UDP-galactopyranose mutase
OW521_RS16005	COG1716	ATPase activity
OW521_RS16005	COG5001	Diguanylate cyclase
OW521_RS16020	COG1349	DNA-binding transcription factor activity
OW521_RS16025	COG0640	Transcriptional regulator
OW521_RS16035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OW521_RS16045	COG0800	Aldolase
OW521_RS16050	COG2271	Major facilitator Superfamily
OW521_RS16085	COG0596	Alpha beta hydrolase
OW521_RS16090	COG0701	Predicted permease
OW521_RS16110	COG0438	transferase activity, transferring glycosyl groups
OW521_RS16125	COG1175	transmembrane transport
OW521_RS16130	COG0395	ABC-type sugar transport system, permease component
OW521_RS16140	COG1609	Transcriptional regulator
OW521_RS16145	COG4948	Mandelate Racemase Muconate Lactonizing
OW521_RS16150	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
OW521_RS16155	COG1126	abc transporter atp-binding protein
OW521_RS16160	COG0765	amino acid transport
OW521_RS16170	COG1169	isochorismate synthase
OW521_RS16175	COG2226	methyltransferase
OW521_RS16185	COG0142	geranyltranstransferase activity
OW521_RS16200	COG2860	membrane
OW521_RS16210	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OW521_RS16215	COG0175	sulfate reduction
OW521_RS16235	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
OW521_RS16245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OW521_RS16250	COG1648	precorrin-2 dehydrogenase activity
OW521_RS16250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OW521_RS16260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OW521_RS16260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OW521_RS16265	COG2186	Transcriptional regulator
OW521_RS16275	COG2508	Transcriptional regulator
OW521_RS16275	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
OW521_RS16280	COG1012	belongs to the aldehyde dehydrogenase family
OW521_RS16330	COG0531	amino acid
OW521_RS16350	COG0531	amino acid
OW521_RS16355	COG0501	Belongs to the peptidase M48B family
OW521_RS16365	COG2837	iron assimilation
OW521_RS16375	COG0672	)-iron permease
OW521_RS16380	COG1666	GTP binding
OW521_RS16410	COG1131	(ABC) transporter
OW521_RS16415	COG1309	transcriptional regulator
OW521_RS16420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OW521_RS16430	COG0318	PFAM AMP-dependent synthetase and ligase
OW521_RS16450	COG0346	lactoylglutathione lyase activity
OW521_RS16520	COG1388	LysM domain
OW521_RS16520	COG3942	CHAP domain
OW521_RS16535	COG1940	carbohydrate kinase activity
OW521_RS16540	COG0366	Alpha amylase catalytic
OW521_RS16545	COG4989	oxidoreductase activity
OW521_RS16555	COG2182	Extracellular solute-binding protein
OW521_RS16560	COG1175	transmembrane transport
OW521_RS16565	COG0395	ABC-type sugar transport system, permease component
OW521_RS16570	COG4948	Mandelate Racemase Muconate Lactonizing
OW521_RS16580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OW521_RS16610	COG2030	dehydratase
OW521_RS16615	COG2030	dehydratase
OW521_RS16620	COG0738	Major facilitator superfamily
OW521_RS16625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
OW521_RS16640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OW521_RS16655	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
OW521_RS16665	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
OW521_RS16670	COG0456	acetyltransferase
OW521_RS16675	COG0745	RESPONSE REGULATOR receiver
OW521_RS16685	COG3485	protocatechuate 3,4-dioxygenase
OW521_RS16695	COG0354	folic acid binding
OW521_RS16745	COG2197	response regulator
OW521_RS16750	COG0436	Aminotransferase
OW521_RS16770	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
OW521_RS16775	COG0081	regulation of translation
OW521_RS16790	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
OW521_RS16795	COG0222	ribosome binding
OW521_RS16800	COG0442	prolyl-tRNA aminoacylation
OW521_RS16805	COG0183	Belongs to the thiolase family
OW521_RS16810	COG0085	RNA polymerase activity
OW521_RS16815	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
OW521_RS16820	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
OW521_RS16825	COG0049	tRNA binding
OW521_RS16830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OW521_RS16835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OW521_RS16840	COG2723	6-phospho-beta-galactosidase activity
OW521_RS16845	COG0051	transcription antitermination factor activity, RNA binding
OW521_RS16850	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
OW521_RS16855	COG0088	Forms part of the polypeptide exit tunnel
OW521_RS16860	COG0089	rRNA binding
OW521_RS16865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
OW521_RS16870	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OW521_RS16875	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
OW521_RS16880	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
OW521_RS16885	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
OW521_RS16895	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
OW521_RS16900	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
OW521_RS16905	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
OW521_RS16910	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
OW521_RS16915	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
OW521_RS16920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
OW521_RS16930	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
OW521_RS16935	COG1841	ribosomal large subunit assembly
OW521_RS16940	COG0200	Binds to the 23S rRNA
OW521_RS16950	COG0563	adenylate kinase activity
OW521_RS16970	COG1175	transmembrane transport
OW521_RS16975	COG3191	aminopeptidase activity
OW521_RS16980	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
OW521_RS16985	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OW521_RS16990	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
OW521_RS16995	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
OW521_RS17000	COG0202	RNA polymerase activity
OW521_RS17005	COG0203	ribosomal protein L17
OW521_RS17010	COG0101	tRNA pseudouridine synthase activity
OW521_RS17030	COG2894	cell division
OW521_RS17065	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
OW521_RS17070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OW521_RS17075	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OW521_RS17090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OW521_RS17095	COG1876	peptidase activity
OW521_RS17100	COG1072	(Pantothenic acid kinase))
OW521_RS17110	COG0736	holo-[acyl-carrier-protein] synthase activity
OW521_RS17135	COG0667	Aldo Keto reductase
OW521_RS17150	COG2759	Belongs to the formate--tetrahydrofolate ligase family
OW521_RS17155	COG0438	transferase activity, transferring glycosyl groups
OW521_RS17170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OW521_RS17175	COG0802	atpase or kinase
OW521_RS17190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
OW521_RS17195	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
OW521_RS17200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OW521_RS17215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
OW521_RS17220	COG0459	protein refolding
OW521_RS17225	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
OW521_RS17225	COG2755	lipolytic protein G-D-S-L family
OW521_RS17235	COG0516	GMP reductase activity
OW521_RS17240	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
OW521_RS17260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OW521_RS17260	COG0519	Catalyzes the synthesis of GMP from XMP
OW521_RS17285	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OW521_RS17290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OW521_RS17330	COG0582	viral genome integration into host DNA
OW521_RS17450	COG1484	DNA-dependent DNA replication
OW521_RS17470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OW521_RS17490	COG4974	Belongs to the 'phage' integrase family
OW521_RS17510	COG1942	4-Oxalocrotonate Tautomerase
OW521_RS17515	COG0673	inositol 2-dehydrogenase activity
OW521_RS17540	COG1172	Belongs to the binding-protein-dependent transport system permease family
OW521_RS17545	COG1172	Belongs to the binding-protein-dependent transport system permease family
OW521_RS17555	COG1609	Transcriptional regulator
OW521_RS17575	COG0667	Aldo Keto reductase
OW521_RS17605	COG3962	Belongs to the TPP enzyme family
OW521_RS17620	COG0673	inositol 2-dehydrogenase activity
OW521_RS17625	COG1082	Xylose isomerase domain protein TIM barrel
OW521_RS17630	COG2188	Transcriptional regulator
OW521_RS17635	COG2814	Major facilitator Superfamily
OW521_RS17645	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
OW521_RS17660	COG0667	Aldo Keto reductase
OW521_RS17685	COG2159	amidohydrolase
OW521_RS17715	COG0477	Major facilitator Superfamily
OW521_RS17720	COG1053	succinate dehydrogenase
OW521_RS17725	COG1063	alcohol dehydrogenase
OW521_RS17735	COG0583	DNA-binding transcription factor activity
OW521_RS17740	COG1053	succinate dehydrogenase
OW521_RS17745	COG0583	DNA-binding transcription factor activity
OW521_RS17750	COG0477	Major facilitator Superfamily
OW521_RS17755	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OW521_RS17760	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS17775	COG0656	L-ascorbic acid biosynthetic process
OW521_RS17780	COG1053	succinate dehydrogenase
OW521_RS17785	COG2807	transmembrane transport
OW521_RS17790	COG0477	Major facilitator Superfamily
OW521_RS17800	COG1414	Transcriptional regulator
OW521_RS17810	COG0583	DNA-binding transcription factor activity
OW521_RS17830	COG4172	Belongs to the ABC transporter superfamily
OW521_RS17860	COG2814	Major facilitator Superfamily
OW521_RS17895	COG1473	amidohydrolase
OW521_RS17915	COG0154	amidase activity
OW521_RS17990	COG1484	DNA-dependent DNA replication
OW521_RS18000	COG2086	electron transfer activity
OW521_RS18005	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
OW521_RS18010	COG2186	Transcriptional regulator
OW521_RS18015	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS18055	COG0318	PFAM AMP-dependent synthetase and ligase
OW521_RS18060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_RS18065	COG1960	acyl-CoA dehydrogenase activity
OW521_RS18070	COG2267	carboxylic ester hydrolase activity
OW521_RS18080	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
OW521_RS18095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OW521_RS18100	COG1960	acyl-CoA dehydrogenase activity
OW521_RS18125	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS18130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_RS18140	COG1024	Enoyl-CoA hydratase
OW521_RS18165	COG0477	Major facilitator Superfamily
OW521_RS18180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OW521_RS18190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OW521_RS18200	COG1869	D-ribose catabolic process
OW521_RS18210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OW521_RS18225	COG1129	ABC transporter
OW521_RS18230	COG1172	Belongs to the binding-protein-dependent transport system permease family
OW521_RS18240	COG2376	Dihydroxyacetone kinase
OW521_RS18245	COG0698	ribose 5-phosphate isomerase
OW521_RS18250	COG0149	triose-phosphate isomerase activity
OW521_RS18255	COG1349	DNA-binding transcription factor activity
OW521_RS18260	COG1063	alcohol dehydrogenase
OW521_RS18285	COG1609	Transcriptional regulator
OW521_RS18295	COG1175	transmembrane transport
OW521_RS18300	COG0395	ABC-type sugar transport system, permease component
OW521_RS18310	COG0673	inositol 2-dehydrogenase activity
OW521_RS18335	COG0673	inositol 2-dehydrogenase activity
OW521_RS18340	COG1609	Transcriptional regulator
OW521_RS18345	COG1904	glucuronate isomerase
OW521_RS18350	COG0246	Mannitol dehydrogenase
OW521_RS18355	COG4948	Mandelate Racemase Muconate Lactonizing
OW521_RS18380	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OW521_RS18385	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OW521_RS18395	COG5006	permease, DMT superfamily
OW521_RS18445	COG0626	cystathionine gamma-synthase activity
OW521_RS18450	COG2814	Major facilitator Superfamily
OW521_RS18455	COG0583	DNA-binding transcription factor activity
OW521_RS18460	COG2971	BadF BadG BcrA BcrD
OW521_RS18485	COG1174	glycine betaine transport
OW521_RS18490	COG1174	glycine betaine transport
OW521_RS18505	COG2326	polyphosphate kinase activity
OW521_RS18510	COG1722	exodeoxyribonuclease VII activity
OW521_RS18515	COG1570	exodeoxyribonuclease VII activity
OW521_RS18525	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
OW521_RS18535	COG0012	GTP binding
OW521_RS18540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OW521_RS18550	COG4166	transmembrane transport
OW521_RS18555	COG0601	transmembrane transport
OW521_RS18580	COG0601	transmembrane transport
OW521_RS18585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OW521_RS18595	COG1217	gtp-binding protein TYPA
OW521_RS18635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OW521_RS18640	COG3226	Transcriptional regulator
OW521_RS18655	COG2171	N-acyltransferase activity
OW521_RS18660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OW521_RS18665	COG0765	amino acid transport
OW521_RS18670	COG0765	amino acid transport
OW521_RS18675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OW521_RS18680	COG1126	abc transporter atp-binding protein
OW521_RS18710	COG1595	DNA-templated transcription, initiation
OW521_RS18720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OW521_RS18735	COG2239	Acts as a magnesium transporter
OW521_RS18745	COG0006	proline dipeptidase activity
OW521_RS18750	COG0613	PHP domain protein
OW521_RS18755	COG2189	Belongs to the N(4) N(6)-methyltransferase family
OW521_RS18760	COG0513	Belongs to the DEAD box helicase family
OW521_RS18765	COG0557	exoribonuclease II activity
OW521_RS18770	COG0352	thiamine-phosphate diphosphorylase activity
OW521_RS18775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OW521_RS18775	COG2022	thiamine diphosphate biosynthetic process
OW521_RS18785	COG2022	thiamine diphosphate biosynthetic process
OW521_RS18790	COG2154	pterin-4-alpha-carbinolamine dehydratase
OW521_RS18805	COG1309	transcriptional regulator
OW521_RS18820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
OW521_RS18825	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
OW521_RS18835	COG3253	May function as heme-dependent peroxidase
OW521_RS18840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OW521_RS18845	COG0181	hydroxymethylbilane synthase activity
OW521_RS18855	COG0113	porphobilinogen synthase activity
OW521_RS18865	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OW521_RS18870	COG1472	Belongs to the glycosyl hydrolase 3 family
OW521_RS18875	COG1126	abc transporter atp-binding protein
OW521_RS18880	COG0765	amino acid transport
OW521_RS18885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OW521_RS18905	COG0210	DNA helicase
OW521_RS18915	COG2816	NAD+ diphosphatase activity
OW521_RS18935	COG3480	Lon protease (S16) C-terminal proteolytic domain
OW521_RS18940	COG1615	UPF0182 protein
OW521_RS18965	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
OW521_RS18975	COG1960	acyl-CoA dehydrogenase activity
OW521_RS18980	COG1842	Phage shock protein A
OW521_RS18990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OW521_RS18995	COG2086	electron transfer activity
OW521_RS19000	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
OW521_RS19010	COG3265	gluconokinase activity
OW521_RS19035	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OW521_RS19040	COG0484	heat shock protein binding
OW521_RS19070	COG0482	sulfurtransferase activity
OW521_RS19090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OW521_RS19125	COG0714	Associated with various cellular activities
OW521_RS19150	COG5000	phosphorelay sensor kinase activity
OW521_RS19150	COG5002	protein histidine kinase activity
OW521_RS19155	COG5401	PFAM Sporulation and spore germination
OW521_RS19165	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
OW521_RS19170	COG3214	Protein conserved in bacteria
OW521_RS19175	COG0653	protein targeting
OW521_RS19210	COG2902	Dehydrogenase
OW521_RS19235	COG1674	ftsk spoiiie
OW521_RS19235	COG0433	COG0433 Predicted ATPase
OW521_RS19245	COG1216	Glycosyl transferase, family 2
OW521_RS19275	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
OW521_RS19335	COG1088	dTDP-glucose 4,6-dehydratase activity
OW521_RS19350	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OW521_RS19395	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
OW521_RS19400	COG2884	Cell division ATP-binding protein ftsE
OW521_RS19405	COG2177	Part of the ABC transporter FtsEX involved in
OW521_RS19415	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
OW521_RS19460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OW521_RS19465	COG0483	inositol monophosphate 1-phosphatase activity
OW521_RS19475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OW521_RS19485	COG1595	DNA-templated transcription, initiation
OW521_RS19515	COG1253	flavin adenine dinucleotide binding
OW521_RS19530	COG1121	(ABC) transporter
OW521_RS19535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OW521_RS19560	COG1064	alcohol dehydrogenase
OW521_RS19570	COG1643	Atp-dependent helicase
OW521_RS19630	COG0018	arginyl-trna synthetase
OW521_RS19635	COG0019	diaminopimelate decarboxylase activity
OW521_RS19640	COG0460	homoserine dehydrogenase
OW521_RS19645	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
OW521_RS19650	COG0083	homoserine kinase activity
OW521_RS19660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
OW521_RS19665	COG2890	protein-(glutamine-N5) methyltransferase activity
OW521_RS19680	COG1216	Glycosyl transferase, family 2
OW521_RS19700	COG0356	it plays a direct role in the translocation of protons across the membrane
OW521_RS19705	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OW521_RS19710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
OW521_RS19715	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OW521_RS19720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OW521_RS19725	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
OW521_RS19730	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OW521_RS19735	COG0355	proton-transporting ATP synthase activity, rotational mechanism
OW521_RS19745	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
OW521_RS19750	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
OW521_RS19760	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OW521_RS19765	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
OW521_RS19780	COG0628	permease
OW521_RS19795	COG1902	pentaerythritol trinitrate reductase activity
OW521_RS19810	COG0363	glucosamine-6-phosphate deaminase activity
OW521_RS19825	COG1335	isochorismatase
OW521_RS19835	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
OW521_RS19845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
OW521_RS19850	COG1234	tRNA 3'-trailer cleavage
OW521_RS19855	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
OW521_RS19860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
OW521_RS19895	COG2149	membrane
OW521_RS19905	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OW521_RS19915	COG0419	ATPase involved in DNA repair
OW521_RS19925	COG1414	Transcriptional regulator
OW521_RS19955	COG0508	dehydrogenase complex catalyzes the overall conversion of
OW521_RS19960	COG0022	dehydrogenase e1 component
OW521_RS19970	COG1113	amino acid transport
OW521_RS19985	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
OW521_RS19990	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
OW521_RS20000	COG1104	cysteine desulfurase activity
OW521_RS20010	COG0179	Fumarylacetoacetate (FAA) hydrolase
OW521_RS20025	COG1305	Transglutaminase-like
OW521_RS20035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OW521_RS20040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OW521_RS20045	COG0579	oxidoreductase
OW521_RS20050	COG0747	negative chemotaxis
OW521_RS20080	COG2133	pyrroloquinoline quinone binding
OW521_RS20105	COG0440	acetolactate synthase activity
OW521_RS20110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
OW521_RS20115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OW521_RS20125	COG0577	efflux transmembrane transporter activity
OW521_RS20125	COG1136	(ABC) transporter
OW521_RS20145	COG0473	3-isopropylmalate dehydrogenase activity
OW521_RS20150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OW521_RS20160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OW521_RS20165	COG0179	Fumarylacetoacetate (FAA) hydrolase
OW521_RS20170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OW521_RS20175	COG0546	phosphoglycolate phosphatase activity
OW521_RS20200	COG1414	Transcriptional regulator
OW521_RS20205	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
OW521_RS20210	COG0066	3-isopropylmalate dehydratase activity
OW521_RS20215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OW521_RS20225	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
OW521_RS20230	COG1181	Belongs to the D-alanine--D-alanine ligase family
OW521_RS20260	COG0742	ribosomal rna small subunit methyltransferase
OW521_RS20275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
OW521_RS20285	COG0333	Belongs to the bacterial ribosomal protein bL32 family
OW521_RS20290	COG0571	ribonuclease III activity
OW521_RS20295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OW521_RS20315	COG2814	Major facilitator Superfamily
OW521_RS20330	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OW521_RS20355	COG2514	catechol 2,3-dioxygenase activity
OW521_RS20365	COG0228	four-way junction DNA binding
OW521_RS20370	COG1837	Belongs to the UPF0109 family
OW521_RS20375	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OW521_RS20380	COG0336	Belongs to the RNA methyltransferase TrmD family
OW521_RS20385	COG0335	large ribosomal subunit rRNA binding
OW521_RS20390	COG0681	Belongs to the peptidase S26 family
OW521_RS20400	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
OW521_RS20410	COG0792	nuclease activity
OW521_RS20425	COG4974	Belongs to the 'phage' integrase family
OW521_RS20440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OW521_RS20445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OW521_RS20460	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
OW521_RS20495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OW521_RS20500	COG3842	ATPase activity
OW521_RS20520	COG2188	Transcriptional regulator
OW521_RS20530	COG1414	Transcriptional regulator
OW521_RS20535	COG0477	Major facilitator Superfamily
OW521_RS20545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OW521_RS20550	COG2084	Dehydrogenase
OW521_RS20555	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS20560	COG1063	alcohol dehydrogenase
OW521_RS20570	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
OW521_RS20575	COG0300	oxidoreductase activity
OW521_RS20580	COG1045	serine acetyltransferase
OW521_RS20590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OW521_RS20595	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OW521_RS20605	COG3022	response to hydroperoxide
OW521_RS20635	COG0242	peptide deformylase activity
OW521_RS20675	COG0024	Methionine aminopeptidase
OW521_RS20690	COG0629	single-stranded DNA binding
OW521_RS20705	COG1946	Acyl-CoA thioesterase
OW521_RS20720	COG0668	transmembrane transport
OW521_RS20760	COG0544	peptidyl-prolyl cis-trans isomerase activity
OW521_RS20765	COG0740	serine-type endopeptidase activity
OW521_RS20770	COG0740	serine-type endopeptidase activity
OW521_RS20775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
OW521_RS20780	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OW521_RS20785	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OW521_RS20790	COG0525	valine-tRNA ligase activity
OW521_RS20795	COG3189	MarR family transcriptional regulator
OW521_RS20810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OW521_RS20815	COG0285	dihydrofolate synthase activity
OW521_RS20825	COG0105	UTP biosynthetic process
OW521_RS20835	COG1530	ribonuclease E activity
OW521_RS20840	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OW521_RS20840	COG0351	phosphomethylpyrimidine kinase
OW521_RS20840	COG0352	thiamine-phosphate diphosphorylase activity
OW521_RS20845	COG0261	This protein binds to 23S rRNA in the presence of protein L20
OW521_RS20850	COG0211	Belongs to the bacterial ribosomal protein bL27 family
OW521_RS20855	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OW521_RS20860	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OW521_RS20865	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
OW521_RS20875	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OW521_RS20885	COG0799	negative regulation of ribosome biogenesis
OW521_RS20895	COG1609	Transcriptional regulator
OW521_RS20905	COG0587	DNA-directed DNA polymerase activity
OW521_RS20940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OW521_RS20945	COG0154	amidase activity
OW521_RS20950	COG2957	Belongs to the agmatine deiminase family
OW521_RS20960	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS20965	COG1309	transcriptional regulator
OW521_RS21000	COG2813	Specifically methylates the guanine in position
OW521_RS21015	COG2182	Extracellular solute-binding protein
OW521_RS21020	COG1175	transmembrane transport
OW521_RS21035	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OW521_RS21040	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OW521_RS21050	COG0583	DNA-binding transcription factor activity
OW521_RS21060	COG1780	Probably involved in ribonucleotide reductase function
OW521_RS21065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OW521_RS21070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OW521_RS21085	COG1234	tRNA 3'-trailer cleavage
OW521_RS21090	COG0412	Dienelactone hydrolase
OW521_RS21135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OW521_RS21160	COG2814	Major facilitator Superfamily
OW521_RS21175	COG3415	Transposase
OW521_RS21175	COG2801	Transposase and inactivated derivatives
OW521_RS21180	COG0492	ferredoxin-NADP+ reductase activity
OW521_RS21185	COG0456	acetyltransferase
OW521_RS21190	COG0494	nUDIX hydrolase
OW521_RS21195	COG1349	DNA-binding transcription factor activity
OW521_RS21205	COG1064	alcohol dehydrogenase
OW521_RS21240	COG1643	Atp-dependent helicase
OW521_RS21260	COG0009	L-threonylcarbamoyladenylate synthase
OW521_RS21290	COG3483	tryptophan 2,3-dioxygenase activity
OW521_RS21320	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
OW521_RS21325	COG2050	protein possibly involved in aromatic compounds catabolism
OW521_RS21335	COG4552	Acetyltransferase involved in intracellular survival and related
OW521_RS21345	COG0539	negative regulation of cytoplasmic translation
OW521_RS21350	COG1739	Uncharacterized protein family UPF0029
OW521_RS21355	COG0237	dephospho-CoA kinase activity
OW521_RS21355	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
OW521_RS21360	COG0556	nucleotide-excision repair
OW521_RS21390	COG4106	trans-aconitate 2-methyltransferase activity
OW521_RS21415	COG0546	phosphoglycolate phosphatase activity
OW521_RS21425	COG0322	excinuclease ABC activity
OW521_RS21435	COG0391	Required for morphogenesis under gluconeogenic growth conditions
OW521_RS21440	COG1481	regulation of sporulation
OW521_RS21445	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OW521_RS21450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OW521_RS21455	COG0126	phosphoglycerate kinase activity
OW521_RS21460	COG0149	triose-phosphate isomerase activity
OW521_RS21465	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OW521_RS21475	COG0363	glucosamine-6-phosphate deaminase activity
OW521_RS21490	COG0166	Belongs to the GPI family
OW521_RS21495	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OW521_RS21505	COG0109	protoheme IX farnesyltransferase activity
OW521_RS21510	COG1612	heme a metabolic process
OW521_RS21520	COG1131	(ABC) transporter
OW521_RS21545	COG0396	ATPase activity
OW521_RS21550	COG2151	metal-sulfur cluster biosynthetic enzyme
OW521_RS21570	COG1122	ATPase activity
OW521_RS21575	COG1268	BioY protein
OW521_RS21585	COG0488	(ABC) transporter
OW521_RS21615	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS21620	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS21625	COG0560	Phosphoserine phosphatase
OW521_RS21625	COG3830	Belongs to the UPF0237 family
OW521_RS21630	COG1119	ATPase activity
OW521_RS21645	COG0254	rRNA binding
OW521_RS21670	COG2855	membrane
OW521_RS21695	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
OW521_RS21700	COG0297	glycogen (starch) synthase activity
OW521_RS21720	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS21740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OW521_RS21760	COG0656	L-ascorbic acid biosynthetic process
OW521_RS21765	COG1968	undecaprenyl-diphosphatase activity
OW521_RS21770	COG0215	cysteine-tRNA ligase activity
OW521_RS21780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OW521_RS21785	COG1994	Peptidase M50
OW521_RS21785	COG0517	IMP dehydrogenase activity
OW521_RS21795	COG1222	aaa ATPase
OW521_RS21800	COG4122	O-methyltransferase activity
OW521_RS21810	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
OW521_RS21815	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
OW521_RS21820	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
OW521_RS21825	COG0545	Peptidyl-prolyl cis-trans isomerase
OW521_RS21845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OW521_RS21850	COG0805	protein transport
OW521_RS21855	COG4581	dead DEAH box helicase
OW521_RS21860	COG1574	metal-dependent hydrolase with the TIM-barrel fold
OW521_RS21865	COG1216	Glycosyl transferase, family 2
OW521_RS21895	COG0242	peptide deformylase activity
OW521_RS21910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OW521_RS21915	COG3424	synthase
OW521_RS21925	COG4974	Belongs to the 'phage' integrase family
OW521_RS21975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OW521_RS21990	COG1280	lysine exporter protein (LysE YggA)
OW521_RS21995	COG1316	TRANSCRIPTIONal
OW521_RS22000	COG2755	lipolytic protein G-D-S-L family
OW521_RS22010	COG1280	lysine exporter protein (LysE YggA)
OW521_RS22030	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OW521_RS22035	COG1845	cytochrome c oxidase, subunit III
OW521_RS22040	COG2010	Cytochrome c
OW521_RS22045	COG0723	plastoquinol--plastocyanin reductase activity
OW521_RS22050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
OW521_RS22055	COG2188	Transcriptional regulator
OW521_RS22060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OW521_RS22070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OW521_RS22075	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OW521_RS22095	COG0167	dihydroorotate dehydrogenase activity
OW521_RS22110	COG2267	carboxylic ester hydrolase activity
OW521_RS22115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OW521_RS22120	COG1381	Involved in DNA repair and RecF pathway recombination
OW521_RS22125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OW521_RS22130	COG3590	peptidase
OW521_RS22135	COG1316	TRANSCRIPTIONal
OW521_RS22140	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OW521_RS22150	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
OW521_RS22170	COG0484	heat shock protein binding
OW521_RS22175	COG1420	regulation of RNA biosynthetic process
OW521_RS22195	COG0481	GTPase activity
OW521_RS22205	COG0268	Binds directly to 16S ribosomal RNA
OW521_RS22240	COG1307	EDD domain protein, DegV family
OW521_RS22245	COG0495	leucyl-tRNA aminoacylation
OW521_RS22250	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OW521_RS22255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OW521_RS22260	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
OW521_RS22265	COG2390	Transcriptional regulator
OW521_RS22270	COG0656	L-ascorbic acid biosynthetic process
OW521_RS22280	COG0438	transferase activity, transferring glycosyl groups
OW521_RS22290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
OW521_RS22300	COG1758	RNA polymerase activity
OW521_RS22305	COG0194	GDP metabolic process
OW521_RS22310	COG0194	GDP metabolic process
OW521_RS22315	COG0284	orotidine-5'-phosphate decarboxylase activity
OW521_RS22320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
OW521_RS22325	COG0505	Belongs to the CarA family
OW521_RS22335	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OW521_RS22340	COG0540	Belongs to the ATCase OTCase family
OW521_RS22345	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
OW521_RS22350	COG0745	RESPONSE REGULATOR receiver
OW521_RS22355	COG5002	protein histidine kinase activity
OW521_RS22365	COG0438	transferase activity, transferring glycosyl groups
OW521_RS22370	COG0438	transferase activity, transferring glycosyl groups
OW521_RS22375	COG1132	(ABC) transporter
OW521_RS22395	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
OW521_RS22410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OW521_RS22415	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OW521_RS22425	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
OW521_RS22430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OW521_RS22435	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
OW521_RS22440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OW521_RS22455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OW521_RS22470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
OW521_RS22495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OW521_RS22500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OW521_RS22525	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
OW521_RS22540	COG1196	nuclear chromosome segregation
OW521_RS22550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OW521_RS22555	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OW521_RS22560	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OW521_RS22570	COG2255	four-way junction helicase activity
OW521_RS22575	COG0632	four-way junction helicase activity
OW521_RS22580	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
OW521_RS22585	COG0217	transcriptional regulatory protein
OW521_RS22590	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
OW521_RS22615	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
OW521_RS22625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OW521_RS22635	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
OW521_RS22660	COG0076	glutamate decarboxylase activity
OW521_RS22725	COG0405	Gamma-glutamyltransferase
OW521_RS22730	COG1609	Transcriptional regulator
OW521_RS22735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OW521_RS22740	COG4948	Mandelate Racemase Muconate Lactonizing
OW521_RS22745	COG0246	Mannitol dehydrogenase
OW521_RS22750	COG1063	alcohol dehydrogenase
OW521_RS22755	COG0477	Major facilitator Superfamily
OW521_RS22760	COG0800	Aldolase
OW521_RS22780	COG0515	serine threonine protein kinase
OW521_RS22790	COG3422	double-strand break repair
OW521_RS22800	COG0477	Major facilitator Superfamily
OW521_RS22805	COG1396	sequence-specific DNA binding
OW521_RS22815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_RS22820	COG1024	Enoyl-CoA hydratase
OW521_RS22825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OW521_RS22835	COG1012	belongs to the aldehyde dehydrogenase family
OW521_RS22885	COG2814	Major facilitator Superfamily
OW521_RS22910	COG3226	Transcriptional regulator
OW521_RS22930	COG1012	belongs to the aldehyde dehydrogenase family
OW521_RS22950	COG3387	PFAM Glycoside hydrolase 15-related
OW521_RS22975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OW521_RS23015	COG5434	Belongs to the glycosyl hydrolase 28 family
OW521_RS23015	COG4632	Exopolysaccharide biosynthesis protein
OW521_RS23030	COG0318	PFAM AMP-dependent synthetase and ligase
OW521_RS23035	COG0438	transferase activity, transferring glycosyl groups
OW521_RS23080	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
OW521_RS23140	COG0789	Transcriptional regulator
OW521_RS23145	COG3118	belongs to the thioredoxin family
OW521_RS23155	COG0667	Aldo Keto reductase
OW521_RS23160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OW521_RS23170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
OW521_RS23175	COG0633	Ferredoxin
OW521_RS23175	COG0543	2 iron, 2 sulfur cluster binding
OW521_RS23190	COG0667	Aldo Keto reductase
OW521_RS23195	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
OW521_RS23250	COG0477	Major facilitator Superfamily
OW521_RS23260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OW521_RS23270	COG0154	amidase activity
OW521_RS23275	COG0154	amidase activity
OW521_RS23280	COG1802	Transcriptional regulator
OW521_RS23285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OW521_RS23290	COG1024	Enoyl-CoA hydratase
OW521_RS23300	COG1129	ABC transporter
OW521_RS23305	COG1879	ABC-type sugar transport system periplasmic component
OW521_RS23315	COG0450	alkyl hydroperoxide reductase
OW521_RS23355	COG3511	phospholipase C
OW521_RS23410	COG0667	Aldo Keto reductase
OW521_RS23435	COG0667	Aldo Keto reductase
OW521_RS23470	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
OW521_RS23495	COG0473	3-isopropylmalate dehydrogenase activity
OW521_RS23505	COG1802	Transcriptional regulator
OW521_RS23515	COG4152	abc transporter atp-binding protein
OW521_RS23540	COG1609	Transcriptional regulator
OW521_RS23555	COG0640	Transcriptional regulator
OW521_RS23560	COG0477	Major facilitator Superfamily
OW521_RS23575	COG2902	Dehydrogenase
OW521_RS23600	COG1175	transmembrane transport
OW521_RS23640	COG1073	alpha beta
OW521_RS23645	COG0747	negative chemotaxis
OW521_RS23670	COG1940	carbohydrate kinase activity
OW521_RS23675	COG1082	Xylose isomerase domain protein TIM barrel
OW521_RS23680	COG0673	inositol 2-dehydrogenase activity
OW521_RS23685	COG1609	Transcriptional regulator
OW521_RS23690	COG1940	carbohydrate kinase activity
OW521_RS23695	COG0673	inositol 2-dehydrogenase activity
OW521_RS23715	COG0444	Belongs to the ABC transporter superfamily
OW521_RS23750	COG4638	Rieske (2fe-2S)
OW521_RS23760	COG1028	Short-chain dehydrogenase reductase Sdr
OW521_RS23765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OW521_RS23770	COG3250	beta-galactosidase activity
OW521_RS23785	COG0154	amidase activity
OW521_RS23815	COG4948	Mandelate Racemase Muconate Lactonizing
OW521_RS23820	COG4829	muconolactone delta-isomerase
OW521_RS23825	COG3485	protocatechuate 3,4-dioxygenase
OW521_RS23835	COG3250	beta-galactosidase activity
OW521_RS23845	COG1846	Transcriptional regulator
OW521_RS23860	COG3119	arylsulfatase activity
OW521_RS23865	COG3119	arylsulfatase activity
OW521_RS24025	COG1793	dna ligase
OW521_RS24035	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs