locus-tag class description HL663_RS00025 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HL663_RS00030 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HL663_RS00035 ENOG4105C5H ABC transporter HL663_RS00040 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HL663_RS00045 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HL663_RS00050 ENOG4106839 domain protein HL663_RS00055 ENOG4105F8V Hydrolase, tatD family HL663_RS00060 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HL663_RS00070 ENOG4105E0Y RtcB Protein HL663_RS00170 ENOG4108RIR Molybdenum cofactor biosynthesis protein HL663_RS00175 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HL663_RS00200 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HL663_RS00205 ENOG4105CJ1 ABC, transporter HL663_RS00225 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HL663_RS00235 ENOG4108HH4 Major Facilitator Superfamily HL663_RS00245 ENOG4105BZU Histidine kinase HL663_RS00250 ENOG4105BZU Histidine kinase HL663_RS00255 ENOG4105BZU Histidine kinase HL663_RS00260 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HL663_RS00305 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HL663_RS00310 ENOG41073TP transcriptional regulator HL663_RS00315 ENOG4105DAA L-lactate HL663_RS00320 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HL663_RS00330 ENOG41080R8 Conserved Protein HL663_RS00340 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HL663_RS00350 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HL663_RS00375 ENOG4105BZ1 (ABC) transporter HL663_RS00385 ENOG4105K4H Nlp p60 protein HL663_RS00420 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HL663_RS00440 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HL663_RS00455 ENOG4105C7N Xanthine uracil vitamin C permease HL663_RS00470 ENOG4105VEQ Cold shock protein HL663_RS00480 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HL663_RS00490 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HL663_RS00525 ENOG410870W N-acetyltransferase HL663_RS00530 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HL663_RS00545 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HL663_RS00575 ENOG4105C3J Cysteine desulfurase HL663_RS00580 ENOG4107XGZ Hydrolase HL663_RS00605 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HL663_RS00615 ENOG4105C1G acyl-Coa dehydrogenase HL663_RS00640 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HL663_RS00655 ENOG4105ETX regulatoR HL663_RS00660 ENOG41062D9 Histidine kinase HL663_RS00665 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HL663_RS00670 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HL663_RS00685 ENOG4107RR1 TRANSCRIPTIONal HL663_RS00690 ENOG4107TVJ ,Oxidoreductase FAD NAD(P)-binding HL663_RS00705 ENOG4105DA5 (ABC) transporter HL663_RS00715 ENOG4105CJ1 ABC, transporter HL663_RS00770 ENOG4105CPQ Dehydrogenase HL663_RS00775 ENOG4108HWW ABC transporter HL663_RS00785 ENOG4105DFW ABC transporter HL663_RS00790 ENOG4105ETE Transcriptional regulator (LacI family HL663_RS00795 ENOG4107RYS Autoinducer-2 (AI-2) kinase HL663_RS00805 ENOG4105WH1 Two component transcriptional regulator luxr family HL663_RS00835 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HL663_RS00840 ENOG4105E1F short-chain dehydrogenase reductase HL663_RS00865 ENOG4105V9V Short-chain dehydrogenase reductase Sdr HL663_RS00875 ENOG4105BZU Histidine kinase HL663_RS00890 ENOG41090KN UPF0303 protein HL663_RS00910 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HL663_RS00915 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HL663_RS00930 ENOG4105D7B Flagellar biosynthesis protein flha HL663_RS00935 ENOG4105D00 flagellar biosynthetic protein flhB HL663_RS00940 ENOG4108TN6 type iii secretion HL663_RS00945 ENOG4105VS8 Flagellar biosynthetic protein fliq HL663_RS00950 ENOG4105CN7 Flagellar biosynthetic protein FliP HL663_RS00960 ENOG4105DD5 Flagellar motor switch protein HL663_RS00965 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HL663_RS00975 ENOG4105ER2 Ompa motb domain protein HL663_RS00980 ENOG4105E14 MotA TolQ exbB proton channel HL663_RS00990 ENOG4105BZE flagellar hook protein, FlgE HL663_RS00995 ENOG4105W00 Flagellar hook capping protein HL663_RS01005 ENOG4105E4C Lytic transglycosylase catalytic HL663_RS01025 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HL663_RS01030 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HL663_RS01035 ENOG41084Q6 flagellar hook-basal body complex protein fliE HL663_RS01040 ENOG4108ZC9 flagellar basal-body rod protein flgc HL663_RS01065 ENOG4105MQ3 flagellar protein FliS HL663_RS01075 ENOG4105I03 Flagellin HL663_RS01080 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HL663_RS01090 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) HL663_RS01095 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HL663_RS01100 ENOG4108KGH TRANSCRIPTIONal HL663_RS01115 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HL663_RS01155 ENOG4105C8N cysteinyl-tRNA synthetase HL663_RS01160 ENOG4105C5X domain protein HL663_RS01210 ENOG4105CSR polyphosphate kinase 2 HL663_RS01225 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HL663_RS01230 ENOG4108YZJ Pfam:DUF2596 HL663_RS01235 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HL663_RS01255 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HL663_RS01280 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme HL663_RS01295 ENOG4108KGH TRANSCRIPTIONal HL663_RS01300 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HL663_RS01320 ENOG4107NHD transcriptional regulator HL663_RS01325 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HL663_RS01335 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HL663_RS01345 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HL663_RS01400 ENOG4107TPY serine threonine protein kinase HL663_RS01440 ENOG4108W2Y isochorismatase HL663_RS01455 ENOG4105F27 Major Facilitator HL663_RS01460 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) HL663_RS01480 ENOG4105VTR Integrase HL663_RS01590 ENOG4105CG3 alpha amylase, catalytic region HL663_RS01610 ENOG4105ETE Transcriptional regulator (LacI family HL663_RS01635 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HL663_RS01655 ENOG4107QKS N-acylglucosamine 2-epimerase HL663_RS01665 ENOG4105DU1 integral membrane protein, terc HL663_RS01680 ENOG4105CGD Nad-dependent epimerase dehydratase HL663_RS01690 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HL663_RS01705 ENOG4107X2D transcriptional regulator, merr family HL663_RS01710 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HL663_RS01725 ENOG4106BRA Membrane HL663_RS01740 ENOG4105DCG PHP domain protein HL663_RS01795 ENOG4105CPC Aldo Keto reductase HL663_RS01805 ENOG4105CNV Aldolase HL663_RS01810 ENOG4105D7N magnesium and cobalt transport protein CorA HL663_RS01820 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) HL663_RS01830 ENOG4105C94 Transporter HL663_RS01845 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HL663_RS01850 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HL663_RS01855 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HL663_RS01865 ENOG4108UKI Enoyl-CoA hydratase HL663_RS01875 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HL663_RS01880 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HL663_RS01910 ENOG4108K8S endonuclease I HL663_RS01915 ENOG4105CXB phosphoribosylaminoimidazole synthetase HL663_RS01930 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HL663_RS01935 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HL663_RS01945 ENOG4105CEY Amp-dependent synthetase and ligase HL663_RS01955 ENOG4105CVK Glutamate decarboxylase HL663_RS01990 ENOG41083YR Protein CrcB homolog HL663_RS01995 ENOG41083TI Protein CrcB homolog HL663_RS02050 ENOG4105C3Q Glycosyl transferase, family 2 HL663_RS02085 ENOG4108UQ5 membrane protein YcdZ HL663_RS02090 ENOG4105CPQ Dehydrogenase HL663_RS02105 ENOG4107W6X Transcriptional regulator HL663_RS02300 ENOG4108RYK Nad-dependent epimerase dehydratase HL663_RS02325 ENOG4105DRR Transcriptional regulator, GntR family HL663_RS02350 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HL663_RS02360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HL663_RS02365 ENOG4105BZU Histidine kinase HL663_RS02375 ENOG4105EDW glycosyl transferase, family 39 HL663_RS02410 ENOG4108JE9 extracellular solute-binding protein family 1 HL663_RS02420 ENOG4105DEI Mannitol dehydrogenase HL663_RS02425 ENOG4108KGH TRANSCRIPTIONal HL663_RS02430 ENOG4105CJN penicillin-binding protein HL663_RS02435 ENOG4105VEQ Cold shock protein HL663_RS02440 ENOG4105SHT UspA domain-containing protein HL663_RS02445 ENOG4105C2J ABC transporter HL663_RS02450 ENOG4105CNN ABC, transporter HL663_RS02455 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator HL663_RS02460 ENOG41060NJ transcriptional regulator HL663_RS02510 ENOG4105D7W serine acetyltransferase HL663_RS02520 ENOG4105DF6 Fe-S oxidoreductase HL663_RS02530 ENOG4105E90 ABC transporter HL663_RS02535 ENOG4105E90 ABC transporter HL663_RS02540 ENOG4108IJ8 ABC transporter HL663_RS02555 ENOG4105DHP deoxycytidine triphosphate deaminase HL663_RS02615 ENOG4105CB5 ATP-dependent DNA helicase recG HL663_RS02635 ENOG4105C1G acyl-Coa dehydrogenase HL663_RS02650 ENOG4105CQB FAD linked oxidase domain protein HL663_RS02660 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein HL663_RS02690 ENOG4105C1G acyl-Coa dehydrogenase HL663_RS02715 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 HL663_RS02720 ENOG4105CPP Dehydrogenase, E1 component HL663_RS02765 ENOG4105CMR udp-glucose 4-epimerase HL663_RS02770 ENOG4105CIH Imidazole acetol-phosphate transaminase HL663_RS02780 ENOG41082T9 Membrane HL663_RS02785 ENOG4105CMR udp-glucose 4-epimerase HL663_RS02790 ENOG4105C4M (Ubiquinol oxidase) subunit I HL663_RS02795 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HL663_RS02800 ENOG4108JJ9 ABC, transporter HL663_RS02805 ENOG4108JJ8 (ABC) transporter HL663_RS02835 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HL663_RS02850 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HL663_RS02865 ENOG4107U9B transcriptional regulator HL663_RS02875 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HL663_RS02880 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HL663_RS02885 ENOG4105KJF protein tyrosine phosphatase HL663_RS02890 ENOG4107QTF adenylosuccinate lyase HL663_RS02905 ENOG4105VPX protein, conserved in bacteria HL663_RS02945 ENOG410667J hydrolase HL663_RS02955 ENOG4105E0A ABC, transporter HL663_RS02960 ENOG4105TVJ transport system, permease HL663_RS02965 ENOG4105DQ5 transport system permease protein HL663_RS02980 ENOG4108IUX (ABC) transporter HL663_RS02985 ENOG4105WH1 Two component transcriptional regulator luxr family HL663_RS02990 ENOG4105BZU Histidine kinase HL663_RS03000 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HL663_RS03010 ENOG410829K Lysine exporter protein (Lyse ygga) HL663_RS03030 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HL663_RS03035 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HL663_RS03040 ENOG4105EKT )-iron permease HL663_RS03115 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HL663_RS03120 ENOG4108M8W Monooxygenase HL663_RS03130 ENOG4108N0W Major Facilitator superfamily HL663_RS03145 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HL663_RS03160 ENOG4105CKW Inner membrane protein yedI HL663_RS03200 ENOG4105C26 Dehydrogenase HL663_RS03205 ENOG4107RR1 TRANSCRIPTIONal HL663_RS03235 ENOG4105F8D glycoside hydrolase family 4 HL663_RS03240 ENOG4105E98 transcriptional regulator DeoR family HL663_RS03245 ENOG4107UEK pfkb domain protein HL663_RS03255 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HL663_RS03260 ENOG4105DRS transport system, permease HL663_RS03285 ENOG4105D3R alkyl hydroperoxide reductase HL663_RS03350 ENOG4107UP5 Phosphatidylserine decarboxylase HL663_RS03360 ENOG4105C8Q Methyl-accepting chemotaxis HL663_RS03370 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HL663_RS03375 ENOG4105DGI Alkaline phosphatase HL663_RS03380 ENOG4105KPY Small multidrug resistance protein HL663_RS03425 ENOG4105CE4 GlcNAc 6-P deacetylase HL663_RS03435 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HL663_RS03450 ENOG4105E98 transcriptional regulator DeoR family HL663_RS03455 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HL663_RS03460 ENOG4105C1J atp-dependent rna helicase HL663_RS03480 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HL663_RS03545 ENOG4107R6U sodium dicarboxylate symporter HL663_RS03555 ENOG4105CJA serine threonine protein kinase HL663_RS03570 ENOG4108S01 response regulator HL663_RS03595 ENOG41061GT Aldolase HL663_RS03600 ENOG4106M32 3-dehydroquinate synthase HL663_RS03620 ENOG4105DRS transport system, permease HL663_RS03680 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HL663_RS03685 ENOG41067HS methyltransferase HL663_RS03700 ENOG4108UQY Iron-storage protein HL663_RS03725 ENOG41067RQ csbd family HL663_RS03755 ENOG4105VBF alkaline shock protein HL663_RS03770 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HL663_RS03785 ENOG4105BZW Glycerate kinase HL663_RS03815 ENOG4105CHH sulfate transporter HL663_RS03845 ENOG4105EUB pirin domain protein HL663_RS03865 ENOG4105HZM Fha domain containing protein HL663_RS03880 ENOG4105CJN penicillin-binding protein HL663_RS03900 ENOG4108U4N (sortase) family HL663_RS03905 ENOG4105ZJT Cell division protein CrgA HL663_RS03910 ENOG4107ZXI Rhomboid family HL663_RS03975 ENOG4108ZED Transmembrane domain of unknown function (DUF3566) HL663_RS03980 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HL663_RS03985 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HL663_RS03995 ENOG4105D4Y metalloprotease HL663_RS04000 ENOG4105E39 Enoyl-CoA hydratase HL663_RS04015 ENOG4105K7N UPF0232 protein HL663_RS04030 ENOG4108J5G 6-phosphogluconate dehydrogenase HL663_RS04035 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HL663_RS04040 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HL663_RS04045 ENOG41084CH 50S ribosomal protein l34 HL663_RS04050 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HL663_RS04055 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HL663_RS04065 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HL663_RS04070 ENOG4107QJE Chromosome Partitioning Protein HL663_RS04080 ENOG4105K63 Thioredoxin HL663_RS04085 ENOG4105C3M thioredoxin reductase HL663_RS04150 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HL663_RS04170 ENOG4105CZA synthase HL663_RS04180 ENOG4105BZ4 penicillin-binding protein HL663_RS04190 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HL663_RS04200 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HL663_RS04205 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HL663_RS04215 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HL663_RS04280 ENOG4105FDF Could be involved in DNA repair (By similarity) HL663_RS04295 ENOG4105DQE DNA ligase HL663_RS04325 ENOG4105CRK lysyL-tRNA synthetase HL663_RS04340 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HL663_RS04345 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HL663_RS04360 ENOG4105DH8 myo-inositol catabolism HL663_RS04365 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HL663_RS04370 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HL663_RS04375 ENOG4105C26 Dehydrogenase HL663_RS04380 ENOG4105S7A ErfK ybiS ycfS ynhG family protein HL663_RS04390 ENOG4105K4I Scp-like extracellular HL663_RS04405 ENOG4108JQ9 ABC transporter HL663_RS04415 ENOG4105UIB (ABC) transporter HL663_RS04420 ENOG4105DIH basic membrane HL663_RS04425 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HL663_RS04435 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HL663_RS04440 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HL663_RS04455 ENOG4107QI1 Mate efflux family protein HL663_RS04460 ENOG4105CYC Transferase HL663_RS04470 ENOG4105CDU Replicative dna helicase HL663_RS04485 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HL663_RS04520 ENOG4105DRS transport system, permease HL663_RS04535 ENOG4105ETE Transcriptional regulator (LacI family HL663_RS04560 ENOG4108RWI nicotinamidase HL663_RS04565 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HL663_RS04575 ENOG4105CEU Arginine dihydrolase HL663_RS04615 ENOG4105CMR udp-glucose 4-epimerase HL663_RS04650 ENOG4107QJT sodium dicarboxylate symporter HL663_RS04655 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HL663_RS04660 ENOG4108V9W transcriptional regulatory protein HL663_RS04675 ENOG4105C57 major facilitator superfamily HL663_RS04695 ENOG4107R7A Allophanate hydrolase subunit 2 HL663_RS04700 ENOG4105P4J Allophanate hydrolase, subunit 1 HL663_RS04705 ENOG4105E7W lamb ycsf family protein HL663_RS04735 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HL663_RS04740 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HL663_RS04745 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HL663_RS04780 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein HL663_RS04785 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HL663_RS04800 ENOG4105D8T Acyltransferase HL663_RS04810 ENOG4105C9Q fumarate hydratase class II HL663_RS04815 ENOG4105C0D helicase HL663_RS04820 ENOG4105BZU Histidine kinase HL663_RS04825 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HL663_RS04840 ENOG4105C57 major facilitator superfamily HL663_RS04845 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HL663_RS04860 ENOG4108V1U phospholipid-binding protein HL663_RS04865 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HL663_RS04870 ENOG4105W0E 50S ribosomal protein L33 HL663_RS04875 ENOG4105KDC 50s ribosomal protein l28 HL663_RS04880 ENOG4105NRA 50s ribosomal protein l31 type b HL663_RS04890 ENOG4108BT0 50S ribosomal protein L32 HL663_RS04895 ENOG4108638 50S ribosomal protein L36 HL663_RS04900 ENOG4105K70 DNA-binding protein HL663_RS04910 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HL663_RS04915 ENOG4105EB3 Histidine kinase HL663_RS04925 ENOG41080RH Thioredoxin HL663_RS04930 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HL663_RS04935 ENOG4105VPX protein, conserved in bacteria HL663_RS04960 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HL663_RS04985 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HL663_RS04995 ENOG4105C5X domain protein HL663_RS05005 ENOG4108IUZ ABC transporter HL663_RS05010 ENOG4108IV0 ABC, transporter HL663_RS05015 ENOG4105C32 Amino acid ABC transporter (Permease) HL663_RS05040 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) HL663_RS05045 ENOG4105ETE Transcriptional regulator (LacI family HL663_RS05060 ENOG4105C2X Arabinose 5-phosphate isomerase HL663_RS05075 ENOG4107RSM transcriptional regulator HL663_RS05105 ENOG4105EYF MMPL domain protein HL663_RS05135 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HL663_RS05185 ENOG4105F27 Major Facilitator HL663_RS05190 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HL663_RS05195 ENOG41090U3 tautomerase HL663_RS05200 ENOG4106YT9 Enoyl-CoA hydratase HL663_RS05205 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HL663_RS05215 ENOG4105C1G acyl-Coa dehydrogenase HL663_RS05235 ENOG4108JQ1 Dehydrogenase HL663_RS05250 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HL663_RS05260 ENOG4105H3G oxidoreductase HL663_RS05265 ENOG4105EG6 Saccharopine dehydrogenase HL663_RS05270 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HL663_RS05285 ENOG4108TCJ secreted hydrolase HL663_RS05305 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HL663_RS05325 ENOG4105CPQ Dehydrogenase HL663_RS05345 ENOG4108VC7 Protein of unknown function (DUF2587) HL663_RS05355 ENOG4105VMP Transcriptional regulator HL663_RS05380 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HL663_RS05400 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HL663_RS05410 ENOG4108MRH transcriptional regulatory protein HL663_RS05435 ENOG4105SHT UspA domain-containing protein HL663_RS05440 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HL663_RS05450 ENOG4105BZ1 (ABC) transporter HL663_RS05455 ENOG4105C84 Histidine ammonia-lyase HL663_RS05465 ENOG4105CGP Urocanate hydratase HL663_RS05470 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HL663_RS05485 ENOG4105CI2 imidazolone-5-propionate hydrolase HL663_RS05495 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein HL663_RS05500 ENOG4108JJB ABC transporter HL663_RS05505 ENOG4105C0R drug resistance transporter emrb qaca subfamily HL663_RS05515 ENOG4105C0R drug resistance transporter emrb qaca subfamily HL663_RS05520 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HL663_RS05525 ENOG4105DWV Homoserine O-trans-acetylase HL663_RS05560 ENOG4105CS9 pantothenic acid kinase HL663_RS05575 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HL663_RS05595 ENOG4105CFG Acts as a chaperone (By similarity) HL663_RS05600 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HL663_RS05605 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HL663_RS05610 ENOG4105KNI merR family transcriptional Regulator HL663_RS05635 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HL663_RS05645 ENOG4107UWP Major facilitator superfamily MFS_1 HL663_RS05655 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HL663_RS05690 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HL663_RS05695 ENOG4108V0P LemA family HL663_RS05705 ENOG4107QWP ABC-2 type transporter HL663_RS05710 ENOG4105ENE Histidine kinase HL663_RS05715 ENOG4105WH1 Two component transcriptional regulator luxr family HL663_RS05720 ENOG4105DQR SNARE associated Golgi HL663_RS05725 ENOG4105EAB amino acid AbC transporter HL663_RS05730 ENOG4105EAD ABC transporter HL663_RS05745 ENOG4105DEN Luciferase family HL663_RS05755 ENOG4105GRZ Ycii-related protein HL663_RS05785 ENOG4105BZU Histidine kinase HL663_RS05790 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HL663_RS05795 ENOG4108VYJ response regulator receiver protein HL663_RS05800 ENOG4105C8Q Methyl-accepting chemotaxis HL663_RS05830 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HL663_RS05835 ENOG4105EEM helicase HL663_RS05840 ENOG4105C12 Phosphoribosylglycinamide synthetase HL663_RS05845 ENOG4105DEN Luciferase family HL663_RS05855 ENOG4108Z4X TRANSCRIPTIONal HL663_RS05860 ENOG4105DXB Major Facilitator superfamily HL663_RS05870 ENOG4105C8V SAICAR synthetase HL663_RS05890 ENOG4108ETH Formylglycinamide ribotide synthetase HL663_RS05905 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HL663_RS05910 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HL663_RS05915 ENOG4105C7W Xanthine dehydrogenase HL663_RS05930 ENOG4105DYW oxidoreductase HL663_RS05935 ENOG4105RNG membrane HL663_RS05950 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HL663_RS05970 ENOG4105CUB amino acid HL663_RS05985 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HL663_RS05990 ENOG4108Z6B deaminase HL663_RS06005 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN HL663_RS06020 ENOG4105D7A ATP-binding protein HL663_RS06035 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HL663_RS06045 ENOG4105EXC Acyl-transferase HL663_RS06060 ENOG4105D17 glycoside hydrolase, family 3 domain protein HL663_RS06065 ENOG4105EHZ conserved protein UCP016719 HL663_RS06070 ENOG4107S1E Beta-lactamase HL663_RS06075 ENOG4106KNT transcriptional regulator HL663_RS06080 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HL663_RS06090 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HL663_RS06120 ENOG4105EYF MMPL domain protein HL663_RS06150 ENOG4105E2Y ABC, transporter HL663_RS06160 ENOG4108Z20 Acyl-transferase HL663_RS06170 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HL663_RS06185 ENOG4105CFH Aspartokinase HL663_RS06215 ENOG4105WH1 Two component transcriptional regulator luxr family HL663_RS06260 ENOG41064MX Tetr family transcriptional regulator HL663_RS06270 ENOG4105E98 transcriptional regulator DeoR family HL663_RS06285 ENOG4107RCV ABC transporter, permease HL663_RS06305 ENOG41072TH Protein of unknown function (DUF1479) HL663_RS06310 ENOG4105DKQ ROK family HL663_RS06315 ENOG4105DFH Transport of potassium into the cell (By similarity) HL663_RS06325 ENOG4105DIN metallophosphoesterase HL663_RS06335 ENOG4105BZ4 penicillin-binding protein HL663_RS06375 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HL663_RS06390 ENOG4105P8F nudix hydrolase HL663_RS06405 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HL663_RS06410 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HL663_RS06425 ENOG4107QN1 sodium solute HL663_RS06435 ENOG4105CPQ Dehydrogenase HL663_RS06440 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HL663_RS06460 ENOG4108HRK Histidine kinase HL663_RS06515 ENOG4108I5C dEAD DEAH box helicase HL663_RS06520 ENOG4105WN5 stage II sporulation protein HL663_RS06525 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for HL663_RS06530 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HL663_RS06545 ENOG4108RQS Two component transcriptional regulator (Winged helix family HL663_RS06550 ENOG4105BZU Histidine kinase HL663_RS06575 ENOG4105EXC Acyl-transferase HL663_RS06580 ENOG4105EXC Acyl-transferase HL663_RS06620 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HL663_RS06625 ENOG4105WH1 Two component transcriptional regulator luxr family HL663_RS06630 ENOG4105BZU Histidine kinase HL663_RS06650 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HL663_RS06665 ENOG4107TXC Transcriptional regulator HL663_RS06685 ENOG4105WH1 Two component transcriptional regulator luxr family HL663_RS06690 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HL663_RS06695 ENOG4105C6E dna polymerase iii HL663_RS06730 ENOG4105F0N pyrophosphate phospho-hydrolase HL663_RS06745 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HL663_RS06760 ENOG4105EUJ GTP cyclohydrolase i HL663_RS06765 ENOG4105EEI dihydropteroate synthase HL663_RS06780 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HL663_RS06800 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HL663_RS06805 ENOG4108IYU L-aspartate oxidase HL663_RS06820 ENOG4107XWI flavin reductase domain protein, FMN-binding HL663_RS06830 ENOG41089UC methyltransferase, type 11 HL663_RS06840 ENOG4107R33 ppx gppa phosphatase HL663_RS06845 ENOG4105EY0 Xylose isomerase domain protein TIM barrel HL663_RS06855 ENOG4108FKE two-component system sensor kinase HL663_RS06860 ENOG4108PYU two-component system response regulator HL663_RS06880 ENOG4105II7 pyrroline-5-carboxylate reductase HL663_RS06895 ENOG4107ZYR domain protein HL663_RS06900 ENOG4105DGU Histone deacetylase HL663_RS06930 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HL663_RS06935 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HL663_RS06940 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HL663_RS06945 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HL663_RS06950 ENOG4105D52 delta-aminolevulinic acid dehydratase HL663_RS06960 ENOG4108YYC ycei family HL663_RS06970 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HL663_RS06975 ENOG4108RH7 phosphoglycerate mutase HL663_RS06985 ENOG4107QIV Cytochrome c biogenesis protein HL663_RS06995 ENOG4105CRE cytochrome C HL663_RS07025 ENOG4105CRW Short chain fatty acid transporter HL663_RS07040 ENOG4107TCW O-succinylbenzoate synthase HL663_RS07065 ENOG4105D8V Glucose sorbosone dehydrogenase HL663_RS07070 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HL663_RS07075 ENOG4105P52 geranylgeranyl reductase HL663_RS07080 ENOG4105E4F Isochorismate synthase HL663_RS07085 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HL663_RS07095 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HL663_RS07100 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HL663_RS07105 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HL663_RS07120 ENOG4108IEH NADH dehydrogenase subunit g HL663_RS07125 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HL663_RS07130 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HL663_RS07135 ENOG41087XN oxidoreductase HL663_RS07155 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HL663_RS07165 ENOG4105DCM major facilitator superfamily HL663_RS07180 ENOG410684T prevent-host-death family HL663_RS07185 ENOG4105VG9 Plasmid stabilization system HL663_RS07190 ENOG4105C6T cysteine synthase HL663_RS07205 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HL663_RS07225 ENOG4105DQU oxidoreductase, subunit beta HL663_RS07230 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HL663_RS07250 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HL663_RS07255 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HL663_RS07275 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HL663_RS07295 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HL663_RS07305 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HL663_RS07315 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HL663_RS07325 ENOG4105C8S subunit m HL663_RS07335 ENOG4105D0M Protease HtpX homolog HL663_RS07340 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HL663_RS07365 ENOG4105EET magnesium chelatase HL663_RS07370 ENOG4108VPT UPF0234 protein HL663_RS07390 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HL663_RS07400 ENOG4105T0Z Conserved Protein HL663_RS07410 ENOG4105VG5 Membrane HL663_RS07420 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HL663_RS07455 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HL663_RS07470 ENOG4108PYU two-component system response regulator HL663_RS07475 ENOG4105BZU Histidine kinase HL663_RS07485 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HL663_RS07490 ENOG4105D5P Methylmalonyl-coA mutase HL663_RS07535 ENOG4105WDJ 50S ribosomal protein L33 HL663_RS07540 ENOG410900P UPF0336 protein HL663_RS07550 ENOG4107R4N Cell wall formation (By similarity) HL663_RS07570 ENOG4105XT2 Transcriptional regulator HL663_RS07595 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HL663_RS07600 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HL663_RS07610 ENOG4108VZM 50s ribosomal protein L10 HL663_RS07615 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HL663_RS07675 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HL663_RS07680 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HL663_RS07695 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HL663_RS07700 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HL663_RS07705 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HL663_RS07710 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HL663_RS07720 ENOG4108594 Permease of the drug metabolite transporter HL663_RS07735 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HL663_RS07740 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HL663_RS07745 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HL663_RS07750 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HL663_RS07755 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HL663_RS07760 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HL663_RS07765 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HL663_RS07770 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HL663_RS07775 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HL663_RS07780 ENOG41082SA 50s ribosomal protein l29 HL663_RS07785 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HL663_RS07790 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HL663_RS07795 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HL663_RS07800 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HL663_RS07810 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HL663_RS07815 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HL663_RS07820 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HL663_RS07825 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HL663_RS07830 ENOG410849U 50S ribosomal protein L30 HL663_RS07835 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HL663_RS07845 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HL663_RS07860 ENOG4105CMN Methylmalonyl-coA mutase HL663_RS07875 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HL663_RS07880 ENOG41067V7 50S ribosomal protein L36 HL663_RS07885 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HL663_RS07890 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HL663_RS07900 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HL663_RS07905 ENOG4108ZT0 50S ribosomal protein l17 HL663_RS07910 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HL663_RS07930 ENOG4105C5H ABC transporter HL663_RS07950 ENOG4106BQ7 Glycosyl Transferase HL663_RS07970 ENOG4105XDV HL663_RS08015 ENOG4105WH1 Two component transcriptional regulator luxr family HL663_RS08055 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HL663_RS08060 ENOG4108UJD 30S ribosomal protein S9 HL663_RS08065 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HL663_RS08070 ENOG4108ZHJ Organic hydroperoxide resistance protein HL663_RS08075 ENOG4105D5U fad dependent oxidoreductase HL663_RS08095 ENOG4107GFK fumarate HL663_RS08100 ENOG4105D7K pfkb domain protein HL663_RS08120 ENOG4105IIP Membrane HL663_RS08125 ENOG4105W1N transcriptional regulator HL663_RS08130 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HL663_RS08135 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HL663_RS08165 ENOG4105C3G gtp-binding protein HL663_RS08180 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) HL663_RS08220 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HL663_RS08230 ENOG4105ETX regulatoR HL663_RS08235 ENOG4108YV4 Universal stress protein HL663_RS08240 ENOG4108TCJ secreted hydrolase HL663_RS08245 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HL663_RS08270 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HL663_RS08280 ENOG410842T Pterin carbinolamine dehydratase HL663_RS08285 ENOG4108JQ7 (ABC) transporter HL663_RS08290 ENOG4105C3U ABC transporter HL663_RS08295 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HL663_RS08300 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HL663_RS08305 ENOG4105DEF Extracellular solute-binding protein, family 5 HL663_RS08310 ENOG4105CI3 gtp-binding protein typa HL663_RS08320 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HL663_RS08325 ENOG4105MXW flavin reductase domain protein, FMN-binding HL663_RS08330 ENOG41073R8 VanW family HL663_RS08335 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HL663_RS08340 ENOG4108Z4U Ferredoxin HL663_RS08370 ENOG4108URH decarboxylase HL663_RS08410 ENOG4105DU6 RNA polymerase HL663_RS08425 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HL663_RS08440 ENOG4105CJW magnesium transporter HL663_RS08455 ENOG4105CI0 Citrate lyase HL663_RS08470 ENOG4105EE0 oxidoreductase HL663_RS08485 ENOG4105C1G acyl-Coa dehydrogenase HL663_RS08505 ENOG4107T6F Xaa-Pro aminopeptidase HL663_RS08520 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HL663_RS08545 ENOG4105DB7 PHP domain protein HL663_RS08550 ENOG41081FY multiple antibiotic resistance (MarC)-related HL663_RS08555 ENOG4105BZU Histidine kinase HL663_RS08600 ENOG4105C94 Transporter HL663_RS08615 ENOG4105EJQ L-serine dehydratase HL663_RS08625 ENOG4105C10 Electron transfer flavoprotein HL663_RS08640 ENOG4105C94 Transporter HL663_RS08650 ENOG4108HQS Glycine betaine HL663_RS08655 ENOG4108IJ7 Glycine betaine HL663_RS08660 ENOG4107HP6 Transcriptional regulator HL663_RS08665 ENOG4105F5V trimethylamine methyltransferase HL663_RS08675 ENOG4108Q52 Methyltransferase cognate corrinoid protein HL663_RS08680 ENOG4107VP5 methyltetrahydrofolate corrinoid iron-sulfur protein methyltransferase HL663_RS08715 ENOG4107RSM transcriptional regulator HL663_RS08720 ENOG4107QJE Chromosome Partitioning Protein HL663_RS08725 ENOG4105DQ4 alcohol dehydrogenase HL663_RS08730 ENOG4105C1J atp-dependent rna helicase HL663_RS08740 ENOG4105Y3U Transglycosylase-associated protein HL663_RS08765 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HL663_RS08815 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HL663_RS08865 ENOG41063PX domain protein HL663_RS08875 ENOG4105DJZ UPF0182 protein HL663_RS08885 ENOG4105CEP NADH dehydrogenase HL663_RS08900 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HL663_RS08905 ENOG4107TK4 histidinol-phosphate phosphatase HL663_RS08920 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HL663_RS08925 ENOG4105C3U ABC transporter HL663_RS08930 ENOG4108JQ7 (ABC) transporter HL663_RS08935 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HL663_RS08940 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HL663_RS08950 ENOG4108RAV Conserved protein HL663_RS08960 ENOG4105EMN RNA polymerase sigma factor HL663_RS08965 ENOG4105WMN AntiSigma factor HL663_RS08980 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HL663_RS08985 ENOG4105EIP mannose-6-phosphate isomerase HL663_RS08990 ENOG4108VEQ Superoxide dismutase HL663_RS09005 ENOG4105E5Q amino acid AbC transporter HL663_RS09025 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HL663_RS09040 ENOG4105CB2 alcohol dehydrogenase HL663_RS09055 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HL663_RS09070 ENOG4105C37 (CBS) domain HL663_RS09095 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HL663_RS09100 ENOG4105C75 arginyL-tRNA synthetase HL663_RS09110 ENOG4105D6E homoserine dehydrogenase HL663_RS09115 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HL663_RS09120 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HL663_RS09140 ENOG4105VFB Binds the 23S rRNA (By similarity) HL663_RS09145 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HL663_RS09150 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HL663_RS09155 ENOG4107UIY sua5 ycio yrdc ywlc family protein HL663_RS09160 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HL663_RS09165 ENOG4105D3Q Sugar transferase HL663_RS09175 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) HL663_RS09180 ENOG4106DE0 ATP synthase HL663_RS09185 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HL663_RS09190 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HL663_RS09195 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HL663_RS09200 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HL663_RS09205 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HL663_RS09210 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HL663_RS09235 ENOG4107R7Y intracellular protease Pfpi family HL663_RS09240 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HL663_RS09290 ENOG4105CHU acetyl-coa acetyltransferase HL663_RS09310 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HL663_RS09370 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HL663_RS09375 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) HL663_RS09380 ENOG4105CG3 alpha amylase, catalytic region HL663_RS09385 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HL663_RS09395 ENOG4105DMF Dehydrogenase HL663_RS09415 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HL663_RS09445 ENOG4105C10 Electron transfer flavoprotein HL663_RS09455 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HL663_RS09470 ENOG4105EUB pirin domain protein HL663_RS09480 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HL663_RS09495 ENOG4105DWP Membrane HL663_RS09505 ENOG4105CEY Amp-dependent synthetase and ligase HL663_RS09530 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HL663_RS09565 ENOG4105EN6 Membrane HL663_RS09570 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HL663_RS09575 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HL663_RS09580 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HL663_RS09595 ENOG4105EXC Acyl-transferase HL663_RS09605 ENOG4105EYF MMPL domain protein HL663_RS09630 ENOG4105C01 Dihydroxy-acid dehydratase HL663_RS09655 ENOG4105CM2 brancheD-chain amino acid aminotransferase HL663_RS09660 ENOG4105C7K acetolactate synthase HL663_RS09665 ENOG4108ZP8 Acetolactate synthase small subunit HL663_RS09670 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HL663_RS09680 ENOG4108JQ1 Dehydrogenase HL663_RS09695 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HL663_RS09700 ENOG4105CM2 brancheD-chain amino acid aminotransferase HL663_RS09705 ENOG4105CUB amino acid HL663_RS09710 ENOG4108KN0 Choline kinase HL663_RS09725 ENOG4105CFQ glutamine synthetase HL663_RS09730 ENOG4105C26 Dehydrogenase HL663_RS09735 ENOG4105CHR reductase HL663_RS09740 ENOG4108Z86 Glutamine amidotransferase HL663_RS09760 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HL663_RS09785 ENOG4105CSH Transporter HL663_RS09815 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HL663_RS09830 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HL663_RS09865 ENOG41069M3 Transcriptional regulator HL663_RS09870 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HL663_RS09875 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HL663_RS09880 ENOG4105K70 DNA-binding protein HL663_RS09895 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HL663_RS09905 ENOG4105CPF Cell wall formation (By similarity) HL663_RS09925 ENOG4105VB9 50S ribosomal protein l28 HL663_RS09930 ENOG4105DP4 dak2 domain fusion protein ylov HL663_RS09935 ENOG4105CB5 ATP-dependent DNA helicase recG HL663_RS09940 ENOG4106H78 methyltransferase HL663_RS09950 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HL663_RS09955 ENOG4105EXC Acyl-transferase HL663_RS09965 ENOG41084BZ 50S ribosomal protein L32 HL663_RS09970 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HL663_RS09975 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HL663_RS09980 ENOG4105EXC Acyl-transferase HL663_RS09990 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HL663_RS10015 ENOG4105C9K Endothelin-converting enzyme 1 HL663_RS10020 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HL663_RS10040 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HL663_RS10050 ENOG4108MUZ hydrolase HL663_RS10060 ENOG410635A Membrane HL663_RS10070 ENOG4105K5M 30s ribosomal protein S16 HL663_RS10075 ENOG41082KU UPF0109 protein HL663_RS10080 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HL663_RS10085 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HL663_RS10095 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HL663_RS10105 ENOG4107QYR Signal peptidase i HL663_RS10110 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HL663_RS10120 ENOG4105C26 Dehydrogenase HL663_RS10125 ENOG41080R2 UPF0102 protein HL663_RS10140 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HL663_RS10160 ENOG4105CE9 30S ribosomal protein S2 HL663_RS10165 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HL663_RS10175 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HL663_RS10180 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HL663_RS10185 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HL663_RS10200 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HL663_RS10215 ENOG4105CJP fad dependent oxidoreductase HL663_RS10220 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HL663_RS10230 ENOG4105C26 Dehydrogenase HL663_RS10240 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HL663_RS10245 ENOG4105F38 ABC transporter, permease HL663_RS10250 ENOG4105D38 putrescine abc transporter HL663_RS10265 ENOG4105CDU Replicative dna helicase HL663_RS10270 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HL663_RS10275 ENOG4105DZP Membrane-associated zinc metalloprotease HL663_RS10285 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HL663_RS10300 ENOG4105DFW ABC transporter HL663_RS10305 ENOG4108HWW ABC transporter HL663_RS10310 ENOG4105C2J ABC transporter HL663_RS10320 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HL663_RS10340 ENOG4107QW3 Sucrose phosphorylase HL663_RS10345 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HL663_RS10360 ENOG4105C7Z Conserved Protein HL663_RS10390 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HL663_RS10395 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HL663_RS10405 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase HL663_RS10415 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HL663_RS10430 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HL663_RS10430 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HL663_RS10450 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HL663_RS10455 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HL663_RS10465 ENOG4105CNI cell division protein FtsW HL663_RS10470 ENOG4108IQE Amp-dependent synthetase and ligase HL663_RS10485 ENOG4107QN2 dihydrolipoyl dehydrogenase HL663_RS10520 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HL663_RS10530 ENOG4105C03 ribonuclease HL663_RS10535 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HL663_RS10540 ENOG4105K46 50S ribosomal protein l27 HL663_RS10545 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HL663_RS10550 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HL663_RS10555 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HL663_RS10560 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HL663_RS10565 ENOG4105CKK Glycosyl transferase, family 2 HL663_RS10575 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HL663_RS10580 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HL663_RS10585 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HL663_RS10600 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HL663_RS10605 ENOG4108R3E Dna-3-methyladenine glycosylase i HL663_RS10610 ENOG4107RN3 metallophosphoesterase HL663_RS10615 ENOG4108V06 Glutathione peroxidase HL663_RS10640 ENOG4105C8T Leucyl-tRNA synthetase HL663_RS10645 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HL663_RS10655 ENOG4105F38 ABC transporter, permease HL663_RS10660 ENOG4105D38 putrescine abc transporter HL663_RS10665 ENOG4105CI2 imidazolone-5-propionate hydrolase HL663_RS10670 ENOG4105C9B Cysteine desulfurase HL663_RS10705 ENOG41062D9 Histidine kinase HL663_RS10720 ENOG4105EPR degv family HL663_RS10725 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HL663_RS10730 ENOG4105KQC Competence protein HL663_RS10740 ENOG4105EQ2 LysR family Transcriptional regulator HL663_RS10750 ENOG4107TCE N-acetyltransferase HL663_RS10755 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) HL663_RS10760 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) HL663_RS10770 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HL663_RS10785 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HL663_RS10800 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HL663_RS10805 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HL663_RS10880 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HL663_RS10885 ENOG4105DVT helicase HL663_RS11000 ENOG4105EGE secreted protein HL663_RS11005 ENOG4105ETE Transcriptional regulator (LacI family HL663_RS11065 ENOG4105CPC Aldo Keto reductase HL663_RS11085 ENOG4105ECR NmrA family HL663_RS11090 ENOG4105KVH Transcriptional regulator HL663_RS11125 ENOG4105C8Y Acetylornithine aminotransferase HL663_RS11130 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HL663_RS11150 ENOG4105CPC Aldo Keto reductase HL663_RS11170 ENOG4105CQ7 ATP-dependent helicase HL663_RS11200 ENOG4105DWV Homoserine O-trans-acetylase HL663_RS11205 ENOG4105SHT UspA domain-containing protein HL663_RS11210 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HL663_RS11225 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HL663_RS11230 ENOG4108V6E Cell division protein mraZ HL663_RS11235 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HL663_RS11245 ENOG4105CJN penicillin-binding protein HL663_RS11250 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HL663_RS11260 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HL663_RS11265 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HL663_RS11275 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HL663_RS11280 ENOG4105DFU Cell wall formation (By similarity) HL663_RS11285 ENOG4105ME9 cell division protein FtsQ HL663_RS11290 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HL663_RS11295 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HL663_RS11300 ENOG4105DFA alanine racemase domain protein HL663_RS11305 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HL663_RS11315 ENOG4107VQS DivIVA family HL663_RS11325 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HL663_RS11335 ENOG4105C0B DNA polymerase III (alpha subunit) HL663_RS11360 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HL663_RS11390 ENOG4105KBH arsR family transcriptional regulator HL663_RS11395 ENOG4105PGM cation diffusion facilitator family transporter HL663_RS11400 ENOG41080QG Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HL663_RS11415 ENOG4105E2K Glycosyl transferase (Group 1 HL663_RS11425 ENOG4105BZ1 (ABC) transporter HL663_RS11450 ENOG4105ETE Transcriptional regulator (LacI family HL663_RS11465 ENOG4105G9B Transcriptional regulator HL663_RS11470 ENOG4105CT3 Monooxygenase HL663_RS11475 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HL663_RS11485 ENOG41073TP transcriptional regulator HL663_RS11495 ENOG4105DET Rhamnulokinase HL663_RS11510 ENOG4105ETE Transcriptional regulator (LacI family HL663_RS11515 ENOG4105C5F glutamine synthetase HL663_RS11530 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HL663_RS11535 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HL663_RS11545 ENOG4105D9R oxidoreductase HL663_RS11550 ENOG4105EC3 peptidase S51, dipeptidase E HL663_RS11560 ENOG4105ECP epimerase HL663_RS11585 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HL663_RS11590 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HL663_RS11610 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HL663_RS11615 ENOG4105CHF Glutathione S-transferase HL663_RS11630 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HL663_RS11640 ENOG4105BZW Glycerate kinase HL663_RS11650 ENOG4107T4Z adenosine kinase HL663_RS11655 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HL663_RS11660 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HL663_RS11665 ENOG4105C3J Cysteine desulfurase HL663_RS11670 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HL663_RS11675 ENOG4105BZ9 Cytochrome C oxidase, subunit I HL663_RS11695 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HL663_RS11700 ENOG4107EUI c reductase, iron-sulfur HL663_RS11705 ENOG4107UDY cytochrome C HL663_RS11710 ENOG4105CCU oxidase (Subunit III) HL663_RS11715 ENOG4108I0Q anthranilate phosphoribosyltransferase HL663_RS11760 ENOG4108IQE Amp-dependent synthetase and ligase HL663_RS11775 ENOG4105DKQ ROK family HL663_RS11810 ENOG4105WH1 Two component transcriptional regulator luxr family HL663_RS11815 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HL663_RS11835 ENOG41068JE domain protein HL663_RS11880 ENOG4105C0B DNA polymerase III (alpha subunit) HL663_RS11890 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HL663_RS11910 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HL663_RS11920 ENOG4105ETE Transcriptional regulator (LacI family HL663_RS11925 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HL663_RS11930 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component HL663_RS11935 ENOG4105EPJ extracellular solute-binding protein family 1 HL663_RS11940 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HL663_RS11950 ENOG4105CD5 CoA-binding domain protein HL663_RS11965 ENOG4107W53 thymidine kinase HL663_RS11975 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HL663_RS12015 ENOG4107VEG TrkA-N domain protein HL663_RS12020 ENOG4105C0X amino acid HL663_RS12025 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HL663_RS12035 ENOG4107QM5 aconitate hydratase HL663_RS12040 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HL663_RS12055 ENOG4105ETE Transcriptional regulator (LacI family HL663_RS12065 ENOG4105D9N nucleoside HL663_RS12075 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HL663_RS12125 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HL663_RS12130 ENOG4108KB1 transcriptional regulator, arac family HL663_RS12175 ENOG4105KVH Transcriptional regulator HL663_RS12205 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HL663_RS12210 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HL663_RS12215 ENOG4105CHU acetyl-coa acetyltransferase HL663_RS12240 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HL663_RS12260 ENOG4105C1Q protoporphyrinogen oxidase HL663_RS12265 ENOG4107JTW chlorite dismutase HL663_RS12275 ENOG4105E0X reductase HL663_RS12295 ENOG4105CSR polyphosphate kinase 2 HL663_RS12400 ENOG4108IJ6 ABC transporter HL663_RS12405 ENOG4105ECW sulfate abc transporter HL663_RS12410 ENOG4108I5D sulfate abc transporter HL663_RS12415 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HL663_RS12440 ENOG4105E9Q Acyl-transferase HL663_RS12445 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HL663_RS12455 ENOG4105F0I Aminotransferase HL663_RS12480 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HL663_RS12490 ENOG4105CHU acetyl-coa acetyltransferase HL663_RS12495 ENOG4105CHR reductase HL663_RS12525 ENOG4105RHY Pfam:UPF0157 HL663_RS12540 ENOG4105C22 threonyL-tRNA synthetase HL663_RS12575 ENOG4105E2K Glycosyl transferase (Group 1 HL663_RS12585 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HL663_RS12600 ENOG4105BZU Histidine kinase HL663_RS12610 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HL663_RS12615 ENOG4105CDY transcriptional regulatory protein HL663_RS12620 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HL663_RS12625 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HL663_RS12630 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HL663_RS12640 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HL663_RS12645 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HL663_RS12650 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HL663_RS12655 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HL663_RS12660 ENOG4105C99 atpase involved in dna repair HL663_RS12665 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) HL663_RS12675 ENOG4105CUT histidyl-tRNA synthetase HL663_RS12685 ENOG4105DCF alanine dehydrogenase HL663_RS12700 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HL663_RS12705 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HL663_RS12720 ENOG4105CAT Cytidine monophosphate kinase HL663_RS12725 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HL663_RS12735 ENOG4105C87 Aminotransferase class I and II HL663_RS12765 ENOG4108UW8 fha domain-containing protein HL663_RS12785 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HL663_RS12790 ENOG4105EYH Exonuclease HL663_RS12795 ENOG4107RFY SbcCD D subunit HL663_RS12805 ENOG4108ZM9 phosphoglycerate mutase HL663_RS12815 ENOG4107RTD sua5 ycio yrdc ywlc family protein HL663_RS12825 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HL663_RS12840 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HL663_RS12860 ENOG4105Q70 HL663_RS12870 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HL663_RS12880 ENOG4108UYI beta-alanyl-CoA ammonia lyase HL663_RS12885 ENOG4107CHF 5,6-aminomutase beta subunit HL663_RS12890 ENOG4105EQ5 D-Lysine 5,6-aminomutase alpha subunit HL663_RS12930 ENOG4105FRY Dehydrogenase HL663_RS12935 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HL663_RS12940 ENOG4108Z66 YbaK ebsC protein HL663_RS12950 ENOG4105C3M thioredoxin reductase HL663_RS12955 ENOG4105EW9 transcriptional regulator AsnC family HL663_RS12960 ENOG4105HFS 5'-3' exonuclease HL663_RS12965 ENOG4108W3Q Transcriptional regulator HL663_RS12990 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HL663_RS12995 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HL663_RS13005 ENOG4107TMB Transcriptional regulator HL663_RS13030 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HL663_RS13035 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HL663_RS13040 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HL663_RS13045 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) HL663_RS13050 ENOG4105E5F proteasome HL663_RS13060 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HL663_RS13075 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HL663_RS13100 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HL663_RS13110 ENOG4105C8N cysteinyl-tRNA synthetase HL663_RS13125 ENOG4108JJB ABC transporter HL663_RS13145 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HL663_RS13150 ENOG4105D7N magnesium and cobalt transport protein CorA HL663_RS13155 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HL663_RS13160 ENOG4105DYW oxidoreductase HL663_RS13170 ENOG4105ECP epimerase HL663_RS13175 ENOG4107SET aldo keto reductase HL663_RS13190 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HL663_RS13215 ENOG4105BZU Histidine kinase HL663_RS13230 ENOG4108PYU two-component system response regulator HL663_RS13260 ENOG4105DKW ABC transporter HL663_RS13270 ENOG4107QPH glycogen) synthase HL663_RS13275 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HL663_RS13295 ENOG4105EAC phosphoserine phosphatase HL663_RS13305 ENOG4105CHR reductase HL663_RS13315 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HL663_RS13330 ENOG4105BZ1 (ABC) transporter HL663_RS13335 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HL663_RS13340 ENOG4105C5H ABC transporter HL663_RS13370 ENOG4105VG1 fes assembly suf system protein HL663_RS13375 ENOG4108UNV SUF system FeS assembly protein, NifU family HL663_RS13385 ENOG4105C3K feS assembly ATPase SufC HL663_RS13410 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HL663_RS13425 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) HL663_RS13440 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HL663_RS13450 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HL663_RS13455 ENOG4107QYV phosphohexose isomerase HL663_RS13470 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) HL663_RS13490 ENOG4105CP7 Triose-phosphate isomerase HL663_RS13495 ENOG4105BZA Phosphoglycerate kinase HL663_RS13500 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HL663_RS13505 ENOG4105CIE May be required for sporulation (By similarity) HL663_RS13510 ENOG4105CHW UPF0052 protein HL663_RS13515 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HL663_RS13520 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HL663_RS13535 ENOG4105C32 Amino acid ABC transporter (Permease) HL663_RS13540 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HL663_RS13545 ENOG4105C0Z ABC transporter HL663_RS13550 ENOG4108IV0 ABC, transporter HL663_RS13560 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HL663_RS13565 ENOG4105BZP glycoside hydrolase 15-related HL663_RS13575 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HL663_RS13580 ENOG4107AQZ Membrane HL663_RS13590 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HL663_RS13605 ENOG4105CPC Aldo Keto reductase HL663_RS13610 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HL663_RS13615 ENOG4105E2R ROK family HL663_RS13625 ENOG4105D56 permease protein HL663_RS13630 ENOG4105EG2 ABC transporter, permease HL663_RS13640 ENOG4105CUB amino acid HL663_RS13645 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HL663_RS13660 ENOG410905P Pyridoxamine 5-phosphate HL663_RS13670 ENOG4105BZ7 extracellular solute-binding protein family 1 HL663_RS13675 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HL663_RS13685 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HL663_RS13690 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HL663_RS13710 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HL663_RS13750 ENOG4105KA0 thioesterase Superfamily protein HL663_RS13780 ENOG4105CA9 Pyruvate kinase HL663_RS13790 ENOG4105CBC glutamate synthase HL663_RS13810 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HL663_RS13815 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HL663_RS13820 ENOG4105DK0 Indole-3-glycerol phosphate synthase HL663_RS13840 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HL663_RS13870 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HL663_RS13875 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HL663_RS13885 ENOG4105DJ2 Major Facilitator Superfamily HL663_RS13895 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HL663_RS13900 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase HL663_RS13910 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HL663_RS13915 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HL663_RS13935 ENOG4105DJV ribulose-phosphate 3-epimerase HL663_RS13955 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HL663_RS13965 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HL663_RS13985 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HL663_RS13990 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HL663_RS14000 ENOG4105SKN orotidine 5''-phosphate decarboxylase HL663_RS14005 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HL663_RS14010 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HL663_RS14015 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HL663_RS14020 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HL663_RS14025 ENOG4105CD3 dihydroorotase HL663_RS14030 ENOG4105CXT aspartate transcarbamylase HL663_RS14035 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HL663_RS14060 ENOG410803B Involved in the transcription termination process (By similarity) HL663_RS14065 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HL663_RS14075 ENOG4105D49 3-dehydroquinate synthase HL663_RS14080 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HL663_RS14085 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HL663_RS14095 ENOG4105E2X shikimate dehydrogenase HL663_RS14100 ENOG4105HHA aminodeoxychorismate lyase HL663_RS14105 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HL663_RS14110 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HL663_RS14150 ENOG4105C9M aspartyl-trna synthetase HL663_RS14170 ENOG4105K5B UPF0225 protein HL663_RS14180 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HL663_RS14210 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HL663_RS14215 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HL663_RS14235 ENOG4105DSU hydrolase HL663_RS14260 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HL663_RS14265 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HL663_RS14270 ENOG4108VX5 3-methyladenine DNA glycosylase HL663_RS14275 ENOG4105CH7 arginosuccinase HL663_RS14280 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HL663_RS14285 ENOG4105DBV ornithine carbamoyltransferase HL663_RS14290 ENOG4105C8Y Acetylornithine aminotransferase HL663_RS14295 ENOG4105CAS nag kinase HL663_RS14300 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HL663_RS14310 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HL663_RS14320 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HL663_RS14325 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HL663_RS14335 ENOG4105CH6 catalase HL663_RS14345 ENOG4108RWN rrna methyltransferase HL663_RS14350 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HL663_RS14355 ENOG41084BS 50S ribosomal protein L35 HL663_RS14360 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HL663_RS14375 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HL663_RS14380 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HL663_RS14390 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HL663_RS14395 ENOG4105CIH Imidazole acetol-phosphate transaminase HL663_RS14400 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HL663_RS14405 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HL663_RS14415 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HL663_RS14425 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HL663_RS14430 ENOG4105C5F glutamine synthetase HL663_RS14450 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HL663_RS14470 ENOG4105DFK Polyphosphate glucokinase HL663_RS14525 ENOG4105D9U N-acetyltransferase HL663_RS14550 ENOG4105EGD dinuclear metal center protein, YbgI family HL663_RS14580 ENOG4108JNI Alpha beta hydrolase HL663_RS14585 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HL663_RS14590 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HL663_RS14625 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HL663_RS14630 ENOG4105CDH Citrulline--aspartate ligase HL663_RS14650 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HL663_RS14655 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HL663_RS14675 ENOG4107TPS domain protein HL663_RS14685 ENOG4108VCT Sulfite exporter TauE/SafE HL663_RS14700 ENOG4105CJP fad dependent oxidoreductase HL663_RS14710 ENOG4105CDA abc transporter atp-binding protein HL663_RS14715 ENOG4107UBR Extracellular solute-binding protein family 3 HL663_RS14720 ENOG4108Q1T ABC transporter HL663_RS14725 ENOG4105DRP amino acid AbC transporter HL663_RS14745 ENOG4105BZU Histidine kinase HL663_RS14750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HL663_RS14755 ENOG4105BZU Histidine kinase HL663_RS14770 ENOG4105DYW oxidoreductase HL663_RS14775 ENOG4105F9U Dehydrogenase HL663_RS14810 ENOG4105CK5 oxidoreductase HL663_RS14820 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HL663_RS14830 ENOG4105DEF Extracellular solute-binding protein, family 5 HL663_RS14840 ENOG4105KME endoribonuclease L-psp HL663_RS14850 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HL663_RS14875 ENOG4105VTR Integrase HL663_RS14895 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) HL663_RS14975 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HL663_RS15010 ENOG4105E4C Lytic transglycosylase catalytic HL663_RS15070 ENOG4105E9H Lytic Murein transglycosylase HL663_RS15140 ENOG4105EYH Exonuclease HL663_RS15190 ENOG4105E2A Dehydrogenase HL663_RS15215 ENOG4107U9B transcriptional regulator HL663_RS15265 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HL663_RS15270 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HL663_RS15325 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HL663_RS15335 ENOG4105DSE periplasmic solute binding protein HL663_RS15340 ENOG4105FDK ABC transporter HL663_RS15355 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HL663_RS15370 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HL663_RS15395 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HL663_RS15405 ENOG4105K6H D-cysteine desulfhydrase HL663_RS15430 ENOG4107WYG Transcriptional regulator, luxr family HL663_RS15440 ENOG4108KX4 response regulator HL663_RS15450 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HL663_RS15460 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HL663_RS15470 ENOG4107YU2 histidine triad (hIT) protein HL663_RS15495 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HL663_RS15500 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HL663_RS15535 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HL663_RS15565 ENOG4105WH1 Two component transcriptional regulator luxr family HL663_RS15570 ENOG4107STQ Multicopper oxidase HL663_RS15595 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HL663_RS15620 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HL663_RS15650 ENOG4105CKU formyltetrahydrofolate synthetase HL663_RS15660 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HL663_RS15665 ENOG4107Y49 methyltransferase HL663_RS15670 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HL663_RS15675 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HL663_RS15680 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HL663_RS15685 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HL663_RS15700 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HL663_RS15730 ENOG4105VEQ Cold shock protein HL663_RS15750 ENOG410901E Membrane HL663_RS15760 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HL663_RS15815 ENOG4105DWY Agmatine deiminase HL663_RS15835 ENOG4107QRT dEAD DEAH box helicase HL663_RS15840 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HL663_RS15845 ENOG4105WBV Transcriptional regulator HL663_RS15850 ENOG4105CEV competence damage-inducible protein HL663_RS15860 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HL663_RS15875 ENOG4107QZI cell division protein FtsK HL663_RS15880 ENOG4105CN5 Metallo-Beta-Lactamase HL663_RS15885 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HL663_RS15890 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HL663_RS15895 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HL663_RS15925 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HL663_RS15930 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HL663_RS15935 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HL663_RS15945 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HL663_RS15950 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HL663_RS15970 ENOG4105IW1 AmiS UreI transporter HL663_RS15975 ENOG4107SCA Formamidase (EC 3.5.1.49) HL663_RS15980 ENOG4105GKE subunit e HL663_RS15990 ENOG4108IEG Formate dehydrogenase Alpha subunit HL663_RS16005 ENOG4105FAT Acyl-transferase HL663_RS16040 ENOG4105EEM helicase HL663_RS16040 ENOG4105EEM helicase HL663_RS16080 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HL663_RS16085 ENOG41076QQ Glycosyl transferase, family 2 HL663_RS16090 ENOG4108UW5 maltose o-acetyltransferase HL663_RS16095 ENOG4105K64 Glycosyl transferase, family 2 HL663_RS16120 ENOG4105CJN penicillin-binding protein HL663_RS16140 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HL663_RS16155 ENOG4108M15 ABC transporter HL663_RS16165 ENOG4105BZU Histidine kinase HL663_RS16175 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HL663_RS16220 ENOG4105BZ1 (ABC) transporter HL663_RS16245 ENOG4105PSQ Acyl-transferase HL663_RS16250 ENOG4105EC2 ftsk spoIIIe HL663_RS16300 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HL663_RS16325 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HL663_RS16340 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HL663_RS16355 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HL663_RS16360 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HL663_RS16365 ENOG4106UW1 Major Facilitator superfamily HL663_RS16370 ENOG4105ETE Transcriptional regulator (LacI family HL663_RS16375 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HL663_RS16395 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HL663_RS16405 ENOG4108YZG isomerase HL663_RS16410 ENOG4105MC2 DSBA oxidoreductase HL663_RS16420 ENOG4105D8X mechanosensitive ion channel HL663_RS16430 ENOG4105CG3 alpha amylase, catalytic region HL663_RS16460 ENOG4105C9U ATP-dependent DNA helicase RecQ HL663_RS16480 ENOG4108VW9 Membrane HL663_RS16485 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HL663_RS16490 ENOG4105C29 acyl-CoA thioesterase HL663_RS16495 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HL663_RS16500 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HL663_RS16535 ENOG4105C1G acyl-Coa dehydrogenase HL663_RS16540 ENOG4105YA8 Transcriptional regulator HL663_RS16545 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HL663_RS16555 ENOG4105CKK Glycosyl transferase, family 2 HL663_RS16565 ENOG4105VHU single-stranded DNA-binding protein HL663_RS16570 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HL663_RS16600 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HL663_RS16645 ENOG4105CDV Ompa motb domain protein HL663_RS16665 ENOG4105WH1 Two component transcriptional regulator luxr family HL663_RS16670 ENOG4105ENE Histidine kinase HL663_RS16740 ENOG4105KK4 UPF0060 membrane protein HL663_RS16755 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HL663_RS16770 ENOG4105S7M extracellular small neutral protease HL663_RS16780 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HL663_RS16785 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HL663_RS16790 ENOG4108RQ5 Beta-lactamase domain-containing protein HL663_RS16795 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HL663_RS16805 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HL663_RS16860 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HL663_RS16865 ENOG4108UYU AsnC family transcriptional regulator HL663_RS16870 ENOG4105CGH 5'-nucleotidase HL663_RS16890 ENOG4108UJU UPF0301 protein HL663_RS16895 ENOG4105C1J atp-dependent rna helicase HL663_RS16935 ENOG41067RQ csbd family HL663_RS16945 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HL663_RS16950 ENOG4105E4C Lytic transglycosylase catalytic HL663_RS16955 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) HL663_RS16960 ENOG4105CAK Cell division ATP-binding protein ftsE HL663_RS16975 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HL663_RS16980 ENOG4105C6Z Gluconate HL663_RS16985 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HL663_RS16990 ENOG4107EJG GntR family transcriptional regulator HL663_RS17035 ENOG4105EC2 ftsk spoIIIe HL663_RS17060 ENOG4105C7I Dehydrogenase HL663_RS17065 ENOG4105CXN decarboxylase HL663_RS17090 ENOG4105C26 Dehydrogenase HL663_RS17135 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HL663_RS17150 ENOG4105WH1 Two component transcriptional regulator luxr family HL663_RS17155 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HL663_RS17165 ENOG4105G3P Lipoprotein lpqB HL663_RS17170 ENOG4105BZU Histidine kinase HL663_RS17175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HL663_RS17205 ENOG4107U53 septum site-determining protein minD HL663_RS17250 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 HL663_RS17260 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HL663_RS17275 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HL663_RS17305 ENOG4107QKV phosphomannomutase HL663_RS17345 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HL663_RS17355 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HL663_RS17375 ENOG4107Y2G Glycosyl transferase (Group 1 HL663_RS17425 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HL663_RS17445 ENOG4105EY8 ABC transporter HL663_RS17455 ENOG4107QQG Dehydrogenase HL663_RS17475 ENOG4105EXC Acyl-transferase HL663_RS17480 ENOG4105K64 Glycosyl transferase, family 2 HL663_RS17490 ENOG4105K64 Glycosyl transferase, family 2 HL663_RS17505 ENOG4108KGH TRANSCRIPTIONal HL663_RS17510 ENOG4108KGH TRANSCRIPTIONal HL663_RS17535 ENOG4105D9G High-affinity HL663_RS17585 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HL663_RS17620 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HL663_RS17635 ENOG4105D8K carboxyl transferase HL663_RS17660 ENOG4108W9H Tetr family transcriptional regulator HL663_RS17670 ENOG4107WR6 Maf-like protein HL663_RS17685 ENOG4107QX3 carboxylase HL663_RS17690 ENOG4105C1G acyl-Coa dehydrogenase HL663_RS17705 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HL663_RS17720 ENOG4105ETE Transcriptional regulator (LacI family HL663_RS17740 ENOG4108KTG Membrane protein, drug metabolite transporter HL663_RS17745 ENOG4108ZT1 Transcriptional regulator HL663_RS17750 ENOG4108JIK carboxylase HL663_RS17785 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HL663_RS17805 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HL663_RS17810 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HL663_RS17815 ENOG4105C26 Dehydrogenase HL663_RS17820 ENOG4105C26 Dehydrogenase HL663_RS17825 ENOG4105KNA -acetyltransferase HL663_RS17850 ENOG4108WQ6 secreted protein HL663_RS17855 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HL663_RS17875 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HL663_RS17890 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HL663_RS17915 ENOG4105CIG ABC transporter HL663_RS17945 ENOG4105C31 Tryptophanyl-tRNA synthetase HL663_RS17950 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HL663_RS17965 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HL663_RS17970 ENOG4107TSN permease HL663_RS17995 ENOG4105KJF protein tyrosine phosphatase HL663_RS18015 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HL663_RS18035 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HL663_RS18040 ENOG4105D3Q Sugar transferase HL663_RS18055 ENOG4105E9K Isocitrate dehydrogenase HL663_RS18065 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HL663_RS18075 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HL663_RS18080 ENOG4107REC cytoplasmic protein HL663_RS18085 ENOG4107R1Q Membrane protein FdrA HL663_RS18110 ENOG4105C2W permease HL663_RS18150 ENOG4105DZ6 Band 7 protein HL663_RS18180 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HL663_RS18195 ENOG4105C5B carbamate kinase HL663_RS18200 ENOG4105CWN amidohydrolase HL663_RS18220 ENOG4105S64 Formate nitrite transporter HL663_RS18225 ENOG4105DC1 bifunctional purine biosynthesis protein purh HL663_RS18260 ENOG4105CMV Succinyl-CoA synthetase subunit beta HL663_RS18270 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HL663_RS18300 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HL663_RS18305 ENOG4105DUX Transporter HL663_RS18325 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HL663_RS18335 ENOG4105WH1 Two component transcriptional regulator luxr family HL663_RS18365 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HL663_RS18375 ENOG4105DFM M18 family aminopeptidase HL663_RS18390 ENOG4105E5G Alpha beta hydrolase fold HL663_RS18395 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HL663_RS18415 ENOG4105BZ1 (ABC) transporter HL663_RS18420 ENOG4105BZ1 (ABC) transporter HL663_RS18425 ENOG4107T5V SNARE associated Golgi HL663_RS18445 ENOG4105C26 Dehydrogenase HL663_RS18450 ENOG4107QVP Dehydrogenase HL663_RS18455 ENOG4105C0R drug resistance transporter emrb qaca subfamily HL663_RS18460 ENOG4105KXX peptidase s58 dmpa HL663_RS18470 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HL663_RS18475 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HL663_RS18490 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HL663_RS18505 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HL663_RS18510 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HL663_RS18525 ENOG4108RVA ribokinase HL663_RS18530 ENOG4105DU0 nucleoside hydrolase HL663_RS18545 ENOG4105CP2 von willebrand factor, type a HL663_RS18555 ENOG4105DR5 peptidase HL663_RS18585 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HL663_RS18610 ENOG4108D32 Methyltransferase HL663_RS18660 ENOG4105C3M thioredoxin reductase HL663_RS18665 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HL663_RS18680 ENOG4108097 ATP-binding protein HL663_RS18690 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HL663_RS18700 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HL663_RS18705 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HL663_RS18710 ENOG4105CS9 pantothenic acid kinase HL663_RS18720 ENOG4108IAB Phoh family HL663_RS18725 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HL663_RS18730 ENOG4108UT2 hemolysin iii HL663_RS18740 ENOG4105T1M mycothiol conjugate amidase mca HL663_RS18750 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HL663_RS18790 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HL663_RS18800 ENOG4105C0R drug resistance transporter emrb qaca subfamily HL663_RS18815 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HL663_RS18840 ENOG4107RM1 amidohydrolase HL663_RS18845 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HL663_RS18865 ENOG4108176 endoribonuclease L-psp HL663_RS18870 ENOG4105CHU acetyl-coa acetyltransferase HL663_RS18910 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HL663_RS18915 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HL663_RS18920 ENOG4105DD7 kinase (PfkB family HL663_RS18955 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HL663_RS19020 ENOG4105D3Q Sugar transferase HL663_RS19025 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HL663_RS19030 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HL663_RS19045 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HL663_RS19050 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HL663_RS19055 ENOG4105D94 Major Facilitator Superfamily HL663_RS19060 ENOG4105C5Q Transcriptional regulator