locus-tag	class	description
HL663_RS00025	COG4106	trans-aconitate 2-methyltransferase activity
HL663_RS00035	COG0488	(ABC) transporter
HL663_RS00040	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HL663_RS00045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HL663_RS00050	COG3583	domain protein
HL663_RS00055	COG0084	hydrolase, TatD family'
HL663_RS00060	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HL663_RS00070	COG1690	Belongs to the RtcB family
HL663_RS00120	COG1053	succinate dehydrogenase
HL663_RS00145	COG2318	DinB family
HL663_RS00170	COG0521	Mo-molybdopterin cofactor biosynthetic process
HL663_RS00175	COG0315	cyclic pyranopterin monophosphate synthase activity
HL663_RS00200	COG3263	regulation of cellular component size
HL663_RS00205	COG1131	(ABC) transporter
HL663_RS00225	COG1970	mechanosensitive ion channel activity
HL663_RS00235	COG2814	Major facilitator Superfamily
HL663_RS00245	COG5001	Diguanylate cyclase
HL663_RS00245	COG3447	MASE1 domain protein
HL663_RS00245	COG5002	protein histidine kinase activity
HL663_RS00250	COG5002	protein histidine kinase activity
HL663_RS00250	COG5001	Diguanylate cyclase
HL663_RS00255	COG3300	MHYT domain
HL663_RS00255	COG5001	Diguanylate cyclase
HL663_RS00260	COG0297	glycogen (starch) synthase activity
HL663_RS00305	COG0745	RESPONSE REGULATOR receiver
HL663_RS00310	COG2186	Transcriptional regulator
HL663_RS00315	COG1620	l-lactate permease
HL663_RS00320	COG0247	lactate metabolic process
HL663_RS00325	COG1139	Iron-sulfur cluster binding protein
HL663_RS00330	COG1556	Lactate utilization protein
HL663_RS00350	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_RS00375	COG1132	(ABC) transporter
HL663_RS00385	COG1388	LysM domain
HL663_RS00385	COG0791	NLP P60 protein
HL663_RS00385	COG3103	Sh3 type 3 domain protein
HL663_RS00420	COG0259	pyridoxamine-phosphate oxidase activity
HL663_RS00455	COG2252	PERMEase
HL663_RS00490	COG0745	RESPONSE REGULATOR receiver
HL663_RS00500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HL663_RS00530	COG1136	(ABC) transporter
HL663_RS00530	COG0577	efflux transmembrane transporter activity
HL663_RS00545	COG0459	protein refolding
HL663_RS00575	COG1104	cysteine desulfurase activity
HL663_RS00580	COG0546	phosphoglycolate phosphatase activity
HL663_RS00585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HL663_RS00590	COG0798	PFAM Bile acid sodium symporter
HL663_RS00600	COG0640	Transcriptional regulator
HL663_RS00605	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HL663_RS00615	COG1960	acyl-CoA dehydrogenase activity
HL663_RS00655	COG0745	RESPONSE REGULATOR receiver
HL663_RS00660	COG2205	protein histidine kinase activity
HL663_RS00665	COG2017	converts alpha-aldose to the beta-anomer
HL663_RS00675	COG1063	alcohol dehydrogenase
HL663_RS00690	COG0633	Ferredoxin
HL663_RS00690	COG0543	2 iron, 2 sulfur cluster binding
HL663_RS00695	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HL663_RS00705	COG1131	(ABC) transporter
HL663_RS00715	COG1131	(ABC) transporter
HL663_RS00770	COG1063	alcohol dehydrogenase
HL663_RS00775	COG4214	carbohydrate transport
HL663_RS00785	COG4213	ABC transporter substrate-binding protein
HL663_RS00790	COG1609	Transcriptional regulator
HL663_RS00805	COG2197	response regulator
HL663_RS00835	COG2267	carboxylic ester hydrolase activity
HL663_RS00840	COG0300	oxidoreductase activity
HL663_RS00860	COG1733	regulation of RNA biosynthetic process
HL663_RS00875	COG2205	protein histidine kinase activity
HL663_RS00890	COG4702	Belongs to the UPF0303 family
HL663_RS00910	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HL663_RS00915	COG1216	Glycosyl transferase, family 2
HL663_RS00930	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HL663_RS00935	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HL663_RS00950	COG1338	Plays a role in the flagellum-specific transport system
HL663_RS00965	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HL663_RS00975	COG1360	Flagellar Motor Protein
HL663_RS00980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HL663_RS01005	COG0741	lytic transglycosylase activity
HL663_RS01015	COG1157	protein secretion by the type III secretion system
HL663_RS01025	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HL663_RS01030	COG1766	The M ring may be actively involved in energy transduction
HL663_RS01035	COG1677	Flagellar hook-basal body complex protein FliE
HL663_RS01040	COG1558	bacterial-type flagellum-dependent cell motility
HL663_RS01065	COG1516	flagellar protein fliS
HL663_RS01075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HL663_RS01080	COG1191	sigma factor activity
HL663_RS01090	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HL663_RS01095	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HL663_RS01100	COG1316	TRANSCRIPTIONal
HL663_RS01120	COG3842	ATPase activity
HL663_RS01150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HL663_RS01155	COG0215	cysteine-tRNA ligase activity
HL663_RS01160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL663_RS01225	COG0588	phosphoglycerate mutase activity
HL663_RS01235	COG0438	transferase activity, transferring glycosyl groups
HL663_RS01255	COG1490	D-aminoacyl-tRNA deacylase activity
HL663_RS01280	COG3246	L-lysine catabolic process to acetate
HL663_RS01295	COG1316	TRANSCRIPTIONal
HL663_RS01300	COG3485	protocatechuate 3,4-dioxygenase
HL663_RS01320	COG0745	RESPONSE REGULATOR receiver
HL663_RS01325	COG0456	acetyltransferase
HL663_RS01335	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HL663_RS01400	COG0515	serine threonine protein kinase
HL663_RS01440	COG1335	isochorismatase
HL663_RS01455	COG2814	Major facilitator Superfamily
HL663_RS01460	COG1846	Transcriptional regulator
HL663_RS01480	COG0582	viral genome integration into host DNA
HL663_RS01525	COG1051	belongs to the nudix hydrolase family
HL663_RS01590	COG0366	Alpha amylase catalytic
HL663_RS01595	COG0395	ABC-type sugar transport system, permease component
HL663_RS01610	COG1609	Transcriptional regulator
HL663_RS01635	COG2130	NADP-dependent
HL663_RS01645	COG2119	membrane
HL663_RS01650	COG1305	Transglutaminase-like
HL663_RS01670	COG0415	Belongs to the DNA photolyase family
HL663_RS01680	COG0702	epimerase
HL663_RS01690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HL663_RS01710	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HL663_RS01725	COG2733	membrane
HL663_RS01740	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HL663_RS01740	COG1796	DNA polymerase
HL663_RS01795	COG0667	Aldo Keto reductase
HL663_RS01810	COG0598	Magnesium transport protein CorA
HL663_RS01820	COG1793	dna ligase
HL663_RS01830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HL663_RS01845	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HL663_RS01850	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HL663_RS01855	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HL663_RS01865	COG1024	Enoyl-CoA hydratase
HL663_RS01875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HL663_RS01880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_RS01910	COG2356	endonuclease I
HL663_RS01915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HL663_RS01920	COG1695	Transcriptional regulator
HL663_RS01930	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HL663_RS01935	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HL663_RS01945	COG0318	PFAM AMP-dependent synthetase and ligase
HL663_RS01960	COG2211	Major facilitator Superfamily
HL663_RS01975	COG2133	pyrroloquinoline quinone binding
HL663_RS01990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HL663_RS01995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HL663_RS02030	COG1609	Transcriptional regulator
HL663_RS02050	COG0463	Glycosyl transferase, family 2
HL663_RS02065	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HL663_RS02090	COG1063	alcohol dehydrogenase
HL663_RS02105	COG3284	Transcriptional regulator
HL663_RS02300	COG2910	NAD(P)H-binding
HL663_RS02325	COG1802	Transcriptional regulator
HL663_RS02335	COG3959	Transketolase, thiamine diphosphate binding domain
HL663_RS02340	COG3958	Transketolase
HL663_RS02345	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_RS02350	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HL663_RS02360	COG0745	RESPONSE REGULATOR receiver
HL663_RS02365	COG2205	protein histidine kinase activity
HL663_RS02375	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HL663_RS02400	COG0395	ABC-type sugar transport system, permease component
HL663_RS02410	COG1653	transport
HL663_RS02425	COG1316	TRANSCRIPTIONal
HL663_RS02430	COG0768	penicillin binding
HL663_RS02435	COG1278	Cold shock
HL663_RS02440	COG0589	response to stress
HL663_RS02460	COG1609	Transcriptional regulator
HL663_RS02510	COG1045	serine acetyltransferase
HL663_RS02520	COG0247	lactate metabolic process
HL663_RS02520	COG2181	nitrate reductase activity
HL663_RS02530	COG1174	glycine betaine transport
HL663_RS02535	COG1174	glycine betaine transport
HL663_RS02545	COG0477	Major facilitator Superfamily
HL663_RS02555	COG0717	Belongs to the dCTP deaminase family
HL663_RS02635	COG1960	acyl-CoA dehydrogenase activity
HL663_RS02650	COG0277	FAD linked oxidase domain protein
HL663_RS02660	COG3336	cytochrome c oxidase
HL663_RS02690	COG1960	acyl-CoA dehydrogenase activity
HL663_RS02715	COG0508	dehydrogenase complex catalyzes the overall conversion of
HL663_RS02720	COG0022	dehydrogenase e1 component
HL663_RS02765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HL663_RS02770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HL663_RS02780	COG1950	PFAM Membrane protein of
HL663_RS02785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HL663_RS02790	COG1271	oxidase subunit
HL663_RS02795	COG1294	oxidase, subunit
HL663_RS02800	COG4988	ABC transporter
HL663_RS02805	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HL663_RS02835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HL663_RS02850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HL663_RS02865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL663_RS02880	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HL663_RS02885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HL663_RS02905	COG1937	Protein conserved in bacteria
HL663_RS02945	COG0561	phosphatase activity
HL663_RS02955	COG1120	ATPase activity
HL663_RS02960	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL663_RS02965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL663_RS02980	COG4152	abc transporter atp-binding protein
HL663_RS02985	COG2197	response regulator
HL663_RS02990	COG4585	Histidine kinase
HL663_RS03000	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HL663_RS03010	COG1280	lysine exporter protein (LysE YggA)
HL663_RS03030	COG1597	lipid kinase activity
HL663_RS03035	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HL663_RS03040	COG0672	)-iron permease
HL663_RS03115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HL663_RS03120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_RS03130	COG2814	Major facilitator Superfamily
HL663_RS03145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_RS03150	COG1733	regulation of RNA biosynthetic process
HL663_RS03160	COG2354	Protein conserved in bacteria
HL663_RS03200	COG1012	belongs to the aldehyde dehydrogenase family
HL663_RS03235	COG1486	melibiose metabolic process
HL663_RS03240	COG1349	DNA-binding transcription factor activity
HL663_RS03245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL663_RS03255	COG1175	transmembrane transport
HL663_RS03260	COG0395	ABC-type sugar transport system, permease component
HL663_RS03270	COG0488	(ABC) transporter
HL663_RS03285	COG0450	alkyl hydroperoxide reductase
HL663_RS03315	COG2318	DinB family
HL663_RS03320	COG1403	HNH endonuclease
HL663_RS03350	COG0688	phosphatidylethanolamine metabolic process
HL663_RS03360	COG0840	transmembrane signaling receptor activity
HL663_RS03370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HL663_RS03375	COG3540	Alkaline phosphatase
HL663_RS03380	COG2076	Multidrug Resistance protein
HL663_RS03390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HL663_RS03425	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HL663_RS03435	COG0395	ABC-type sugar transport system, permease component
HL663_RS03450	COG1349	DNA-binding transcription factor activity
HL663_RS03460	COG0513	Belongs to the DEAD box helicase family
HL663_RS03480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HL663_RS03515	COG0488	(ABC) transporter
HL663_RS03545	COG1823	symporter activity
HL663_RS03550	COG0024	Methionine aminopeptidase
HL663_RS03555	COG0515	serine threonine protein kinase
HL663_RS03560	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HL663_RS03570	COG2197	response regulator
HL663_RS03620	COG0395	ABC-type sugar transport system, permease component
HL663_RS03630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HL663_RS03635	COG2197	response regulator
HL663_RS03680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HL663_RS03685	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HL663_RS03690	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_RS03700	COG2193	ferroxidase activity
HL663_RS03725	COG3237	CsbD-like
HL663_RS03755	COG1302	Protein conserved in bacteria
HL663_RS03770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HL663_RS03785	COG1929	Belongs to the glycerate kinase type-1 family
HL663_RS03815	COG0659	secondary active sulfate transmembrane transporter activity
HL663_RS03865	COG1716	ATPase activity
HL663_RS03880	COG0768	penicillin binding
HL663_RS03885	COG0515	serine threonine protein kinase
HL663_RS03900	COG3764	Sortase (surface protein transpeptidase)
HL663_RS03910	COG0705	Rhomboid family
HL663_RS03910	COG0457	Tetratricopeptide repeat
HL663_RS03975	COG3266	domain, Protein
HL663_RS03980	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HL663_RS03985	COG0187	DNA topoisomerase II activity
HL663_RS04000	COG1024	Enoyl-CoA hydratase
HL663_RS04015	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HL663_RS04030	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HL663_RS04035	COG0592	DNA-directed DNA polymerase activity
HL663_RS04040	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HL663_RS04045	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HL663_RS04050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HL663_RS04055	COG0706	membrane insertase activity
HL663_RS04065	COG0357	Ribosomal RNA small subunit methyltransferase G
HL663_RS04070	COG1192	Involved in chromosome partitioning
HL663_RS04080	COG3118	belongs to the thioredoxin family
HL663_RS04095	COG1595	DNA-templated transcription, initiation
HL663_RS04150	COG0714	Associated with various cellular activities
HL663_RS04170	COG1260	myo-inositol-1-phosphate synthase
HL663_RS04180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HL663_RS04190	COG0360	Binds together with S18 to 16S ribosomal RNA
HL663_RS04200	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HL663_RS04205	COG0359	binds to the 23S rRNA
HL663_RS04215	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HL663_RS04265	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HL663_RS04280	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HL663_RS04295	COG1793	dna ligase
HL663_RS04295	COG3285	dna ligase
HL663_RS04325	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HL663_RS04335	COG2188	Transcriptional regulator
HL663_RS04340	COG0673	inositol 2-dehydrogenase activity
HL663_RS04345	COG1082	Xylose isomerase domain protein TIM barrel
HL663_RS04350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL663_RS04360	COG3718	enzyme involved in inositol metabolism
HL663_RS04365	COG3962	Belongs to the TPP enzyme family
HL663_RS04370	COG0673	inositol 2-dehydrogenase activity
HL663_RS04380	COG1376	ErfK ybiS ycfS ynhG family protein
HL663_RS04390	COG2340	Cysteine-rich secretory protein family
HL663_RS04420	COG1744	ABC transporter substrate-binding protein PnrA-like
HL663_RS04425	COG0300	oxidoreductase activity
HL663_RS04435	COG0402	S-adenosylhomocysteine deaminase activity
HL663_RS04440	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HL663_RS04445	COG0405	Gamma-glutamyltransferase
HL663_RS04455	COG0534	Mate efflux family protein
HL663_RS04460	COG0427	acetyl-CoA hydrolase
HL663_RS04470	COG0305	Participates in initiation and elongation during chromosome replication
HL663_RS04485	COG0596	Alpha beta hydrolase
HL663_RS04520	COG0395	ABC-type sugar transport system, permease component
HL663_RS04535	COG1609	Transcriptional regulator
HL663_RS04560	COG1335	isochorismatase
HL663_RS04565	COG1051	belongs to the nudix hydrolase family
HL663_RS04575	COG2235	arginine
HL663_RS04585	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HL663_RS04615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HL663_RS04640	COG3321	synthase
HL663_RS04640	COG0604	alcohol dehydrogenase
HL663_RS04640	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_RS04650	COG1301	dicarboxylic acid transport
HL663_RS04655	COG3290	protein histidine kinase activity
HL663_RS04660	COG4565	transcriptional regulatory protein
HL663_RS04675	COG0477	Major facilitator Superfamily
HL663_RS04680	COG2814	Major facilitator Superfamily
HL663_RS04695	COG1984	allophanate hydrolase subunit 2
HL663_RS04700	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HL663_RS04705	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HL663_RS04735	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_RS04740	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HL663_RS04740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HL663_RS04745	COG2226	methyltransferase
HL663_RS04780	COG3046	protein related to deoxyribodipyrimidine photolyase
HL663_RS04785	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HL663_RS04800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HL663_RS04810	COG0114	fumarate hydratase activity
HL663_RS04815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HL663_RS04820	COG2205	protein histidine kinase activity
HL663_RS04825	COG0745	RESPONSE REGULATOR receiver
HL663_RS04860	COG1881	PFAM PEBP family protein
HL663_RS04865	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HL663_RS04870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HL663_RS04875	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HL663_RS04880	COG0254	rRNA binding
HL663_RS04895	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HL663_RS04900	COG0776	regulation of translation
HL663_RS04910	COG0745	RESPONSE REGULATOR receiver
HL663_RS04915	COG2205	protein histidine kinase activity
HL663_RS04925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HL663_RS04930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HL663_RS04935	COG1937	Protein conserved in bacteria
HL663_RS04960	COG2226	methyltransferase
HL663_RS04985	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HL663_RS04995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL663_RS05005	COG1137	ATPase activity
HL663_RS05035	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_RS05060	COG0517	IMP dehydrogenase activity
HL663_RS05060	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HL663_RS05075	COG0583	DNA-binding transcription factor activity
HL663_RS05105	COG2409	Drug exporters of the RND superfamily
HL663_RS05135	COG0456	acetyltransferase
HL663_RS05185	COG2814	Major facilitator Superfamily
HL663_RS05190	COG1902	pentaerythritol trinitrate reductase activity
HL663_RS05195	COG1942	4-Oxalocrotonate Tautomerase
HL663_RS05200	COG1024	Enoyl-CoA hydratase
HL663_RS05205	COG0243	molybdopterin cofactor binding
HL663_RS05215	COG1960	acyl-CoA dehydrogenase activity
HL663_RS05235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL663_RS05250	COG0456	acetyltransferase
HL663_RS05260	COG2072	flavoprotein involved in K transport
HL663_RS05265	COG3268	Saccharopine dehydrogenase
HL663_RS05270	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HL663_RS05275	COG1070	Carbohydrate kinase
HL663_RS05280	COG2390	Transcriptional regulator
HL663_RS05285	COG2755	lipolytic protein G-D-S-L family
HL663_RS05305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL663_RS05325	COG1063	alcohol dehydrogenase
HL663_RS05355	COG3655	Transcriptional regulator
HL663_RS05380	COG0577	efflux transmembrane transporter activity
HL663_RS05380	COG1136	(ABC) transporter
HL663_RS05400	COG0604	alcohol dehydrogenase
HL663_RS05410	COG4565	transcriptional regulatory protein
HL663_RS05415	COG3290	protein histidine kinase activity
HL663_RS05435	COG0589	response to stress
HL663_RS05440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HL663_RS05450	COG1132	(ABC) transporter
HL663_RS05465	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HL663_RS05470	COG0442	prolyl-tRNA aminoacylation
HL663_RS05485	COG1228	amidohydrolase
HL663_RS05495	COG4721	ABC-type cobalt transport system, permease component
HL663_RS05500	COG1122	ATPase activity
HL663_RS05505	COG0477	Major facilitator Superfamily
HL663_RS05515	COG0477	Major facilitator Superfamily
HL663_RS05520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HL663_RS05525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HL663_RS05560	COG1072	(Pantothenic acid kinase))
HL663_RS05575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_RS05595	COG0443	Heat shock 70 kDa protein
HL663_RS05600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HL663_RS05605	COG0484	heat shock protein binding
HL663_RS05610	COG0789	Transcriptional regulator
HL663_RS05635	COG0542	response to heat
HL663_RS05645	COG0477	Major facilitator Superfamily
HL663_RS05655	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HL663_RS05690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HL663_RS05695	COG1704	LemA family
HL663_RS05705	COG0842	Transport permease protein
HL663_RS05710	COG4585	Histidine kinase
HL663_RS05715	COG2197	response regulator
HL663_RS05720	COG0586	Pfam SNARE associated Golgi protein
HL663_RS05730	COG0765	amino acid transport
HL663_RS05745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_RS05755	COG3795	YCII-related domain
HL663_RS05785	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HL663_RS05790	COG2201	protein-glutamate methylesterase activity
HL663_RS05795	COG0745	RESPONSE REGULATOR receiver
HL663_RS05800	COG0840	transmembrane signaling receptor activity
HL663_RS05810	COG0643	Histidine kinase
HL663_RS05810	COG0784	Response regulator, receiver
HL663_RS05810	COG2198	Histidine kinase
HL663_RS05830	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HL663_RS05835	COG3973	AAA domain
HL663_RS05840	COG0151	Belongs to the GarS family
HL663_RS05845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_RS05860	COG2814	Major facilitator Superfamily
HL663_RS05870	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HL663_RS05890	COG0047	phosphoribosylformylglycinamidine synthase activity
HL663_RS05890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HL663_RS05905	COG2080	2 iron, 2 sulfur cluster binding
HL663_RS05910	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HL663_RS05915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HL663_RS05930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_RS05940	COG1595	DNA-templated transcription, initiation
HL663_RS05950	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HL663_RS05970	COG0531	amino acid
HL663_RS05985	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HL663_RS05990	COG0590	tRNA wobble adenosine to inosine editing
HL663_RS06005	COG0586	Pfam SNARE associated Golgi protein
HL663_RS06020	COG0433	COG0433 Predicted ATPase
HL663_RS06045	COG2755	lipolytic protein G-D-S-L family
HL663_RS06045	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HL663_RS06060	COG1472	Belongs to the glycosyl hydrolase 3 family
HL663_RS06065	COG3876	Protein conserved in bacteria
HL663_RS06070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HL663_RS06075	COG1737	Transcriptional regulator
HL663_RS06080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HL663_RS06090	COG1175	transmembrane transport
HL663_RS06095	COG0395	ABC-type sugar transport system, permease component
HL663_RS06120	COG2409	Drug exporters of the RND superfamily
HL663_RS06150	COG1116	anion transmembrane transporter activity
HL663_RS06170	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HL663_RS06215	COG2197	response regulator
HL663_RS06245	COG1794	racemase activity, acting on amino acids and derivatives
HL663_RS06270	COG1349	DNA-binding transcription factor activity
HL663_RS06310	COG1940	carbohydrate kinase activity
HL663_RS06315	COG3158	transport of potassium into the cell
HL663_RS06325	COG1408	metallophosphoesterase
HL663_RS06335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HL663_RS06345	COG0003	Pfam Anion-transporting ATPase
HL663_RS06375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL663_RS06405	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HL663_RS06410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HL663_RS06425	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HL663_RS06435	COG1063	alcohol dehydrogenase
HL663_RS06440	COG0156	8-amino-7-oxononanoate synthase activity
HL663_RS06445	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HL663_RS06460	COG3275	phosphorelay sensor kinase activity
HL663_RS06515	COG1111	helicase
HL663_RS06515	COG1205	dead DEAH box helicase
HL663_RS06520	COG1366	Belongs to the anti-sigma-factor antagonist family
HL663_RS06525	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HL663_RS06530	COG2890	protein-(glutamine-N5) methyltransferase activity
HL663_RS06545	COG0745	RESPONSE REGULATOR receiver
HL663_RS06550	COG5002	protein histidine kinase activity
HL663_RS06575	COG2755	lipolytic protein G-D-S-L family
HL663_RS06575	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HL663_RS06580	COG2755	lipolytic protein G-D-S-L family
HL663_RS06580	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HL663_RS06620	COG3384	dioxygenase
HL663_RS06625	COG2197	response regulator
HL663_RS06630	COG4585	Histidine kinase
HL663_RS06650	COG1754	DNA topoisomerase type I activity
HL663_RS06650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HL663_RS06665	COG0789	Transcriptional regulator
HL663_RS06685	COG2197	response regulator
HL663_RS06690	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HL663_RS06695	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HL663_RS06730	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HL663_RS06745	COG0037	tRNA processing
HL663_RS06760	COG0302	gtp cyclohydrolase
HL663_RS06765	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HL663_RS06770	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HL663_RS06780	COG0649	NAD binding
HL663_RS06800	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HL663_RS06805	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HL663_RS06820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HL663_RS06830	COG2226	methyltransferase
HL663_RS06840	COG0248	Ppx GppA phosphatase
HL663_RS06845	COG1082	Xylose isomerase domain protein TIM barrel
HL663_RS06855	COG2205	protein histidine kinase activity
HL663_RS06860	COG0745	RESPONSE REGULATOR receiver
HL663_RS06875	COG0506	proline dehydrogenase activity
HL663_RS06880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HL663_RS06895	COG0569	domain protein
HL663_RS06900	COG0123	including yeast histone deacetylase and acetoin utilization protein
HL663_RS06930	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HL663_RS06935	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HL663_RS06940	COG0181	hydroxymethylbilane synthase activity
HL663_RS06945	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HL663_RS06945	COG1648	precorrin-2 dehydrogenase activity
HL663_RS06950	COG0113	porphobilinogen synthase activity
HL663_RS06960	COG2353	YceI-like domain
HL663_RS06970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HL663_RS06975	COG0406	alpha-ribazole phosphatase activity
HL663_RS06985	COG0785	Cytochrome C biogenesis protein
HL663_RS06995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HL663_RS07025	COG2031	fatty acid transporter
HL663_RS07040	COG4948	Mandelate Racemase Muconate Lactonizing
HL663_RS07070	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HL663_RS07075	COG0644	oxidoreductase
HL663_RS07080	COG1169	isochorismate synthase
HL663_RS07085	COG2226	methyltransferase
HL663_RS07095	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL663_RS07100	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL663_RS07105	COG0649	NAD binding
HL663_RS07120	COG1034	ATP synthesis coupled electron transport
HL663_RS07125	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HL663_RS07130	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL663_RS07135	COG0839	Belongs to the complex I subunit 6 family
HL663_RS07165	COG2271	Major facilitator Superfamily
HL663_RS07180	COG2161	toxin-antitoxin pair type II binding
HL663_RS07185	COG2026	Addiction module toxin, RelE StbE family
HL663_RS07205	COG0596	Alpha beta hydrolase
HL663_RS07225	COG1013	pyruvate-flavodoxin oxidoreductase activity
HL663_RS07230	COG0674	pyruvate-flavodoxin oxidoreductase activity
HL663_RS07230	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HL663_RS07250	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL663_RS07255	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL663_RS07275	COG0714	Associated with various cellular activities
HL663_RS07295	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL663_RS07300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HL663_RS07305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL663_RS07315	COG0713	ATP synthesis coupled electron transport
HL663_RS07320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HL663_RS07325	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL663_RS07330	COG1007	ATP synthesis coupled electron transport
HL663_RS07335	COG0501	Belongs to the peptidase M48B family
HL663_RS07340	COG0363	glucosamine-6-phosphate deaminase activity
HL663_RS07355	COG1404	Belongs to the peptidase S8 family
HL663_RS07365	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HL663_RS07370	COG1666	GTP binding
HL663_RS07390	COG0439	Biotin carboxylase
HL663_RS07400	COG3214	Protein conserved in bacteria
HL663_RS07410	COG2149	membrane
HL663_RS07420	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HL663_RS07455	COG0446	pyridine nucleotide-disulphide oxidoreductase
HL663_RS07470	COG0745	RESPONSE REGULATOR receiver
HL663_RS07475	COG5002	protein histidine kinase activity
HL663_RS07485	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HL663_RS07490	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HL663_RS07490	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HL663_RS07490	COG1703	isobutyryl-CoA mutase activity
HL663_RS07535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HL663_RS07540	COG2030	dehydratase
HL663_RS07550	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HL663_RS07560	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HL663_RS07570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL663_RS07585	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HL663_RS07595	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HL663_RS07600	COG0081	regulation of translation
HL663_RS07610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HL663_RS07615	COG0222	ribosome binding
HL663_RS07630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HL663_RS07655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HL663_RS07675	COG0085	RNA polymerase activity
HL663_RS07680	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HL663_RS07695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HL663_RS07700	COG0049	tRNA binding
HL663_RS07705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HL663_RS07710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HL663_RS07720	COG0697	spore germination
HL663_RS07735	COG0051	transcription antitermination factor activity, RNA binding
HL663_RS07740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HL663_RS07745	COG0088	Forms part of the polypeptide exit tunnel
HL663_RS07750	COG0089	rRNA binding
HL663_RS07755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HL663_RS07760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HL663_RS07765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HL663_RS07770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HL663_RS07775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HL663_RS07780	COG0255	Belongs to the universal ribosomal protein uL29 family
HL663_RS07785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HL663_RS07790	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HL663_RS07795	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HL663_RS07800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HL663_RS07810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HL663_RS07815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HL663_RS07825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HL663_RS07830	COG1841	ribosomal large subunit assembly
HL663_RS07835	COG0200	Binds to the 23S rRNA
HL663_RS07845	COG0563	adenylate kinase activity
HL663_RS07875	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HL663_RS07880	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HL663_RS07885	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HL663_RS07890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HL663_RS07900	COG0202	RNA polymerase activity
HL663_RS07905	COG0203	ribosomal protein L17
HL663_RS07910	COG0101	tRNA pseudouridine synthase activity
HL663_RS07970	COG0535	radical SAM domain protein
HL663_RS08015	COG2197	response regulator
HL663_RS08055	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HL663_RS08060	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HL663_RS08065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HL663_RS08070	COG1764	response to oxidative stress
HL663_RS08075	COG0579	oxidoreductase
HL663_RS08080	COG2723	6-phospho-beta-galactosidase activity
HL663_RS08095	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HL663_RS08095	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HL663_RS08125	COG3226	Transcriptional regulator
HL663_RS08130	COG1570	exodeoxyribonuclease VII activity
HL663_RS08135	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HL663_RS08145	COG1322	Protein conserved in bacteria
HL663_RS08150	COG0386	Belongs to the glutathione peroxidase family
HL663_RS08165	COG0012	GTP binding
HL663_RS08180	COG0714	Associated with various cellular activities
HL663_RS08220	COG1404	Belongs to the peptidase S8 family
HL663_RS08230	COG0745	RESPONSE REGULATOR receiver
HL663_RS08235	COG0589	response to stress
HL663_RS08240	COG2755	lipolytic protein G-D-S-L family
HL663_RS08245	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HL663_RS08270	COG0505	Belongs to the CarA family
HL663_RS08280	COG2154	pterin-4-alpha-carbinolamine dehydratase
HL663_RS08285	COG4608	Belongs to the ABC transporter superfamily
HL663_RS08290	COG0444	Belongs to the ABC transporter superfamily
HL663_RS08300	COG0601	transmembrane transport
HL663_RS08305	COG0747	negative chemotaxis
HL663_RS08315	COG0747	negative chemotaxis
HL663_RS08320	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HL663_RS08325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HL663_RS08330	COG2720	vancomycin resistance protein
HL663_RS08335	COG0456	acetyltransferase
HL663_RS08370	COG1611	Belongs to the LOG family
HL663_RS08410	COG1595	DNA-templated transcription, initiation
HL663_RS08420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HL663_RS08440	COG2239	Acts as a magnesium transporter
HL663_RS08455	COG2301	Belongs to the HpcH HpaI aldolase family
HL663_RS08470	COG0673	inositol 2-dehydrogenase activity
HL663_RS08505	COG0006	proline dipeptidase activity
HL663_RS08520	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HL663_RS08545	COG0613	PHP domain protein
HL663_RS08550	COG2095	MarC family integral membrane protein
HL663_RS08555	COG2205	protein histidine kinase activity
HL663_RS08600	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HL663_RS08610	COG1012	belongs to the aldehyde dehydrogenase family
HL663_RS08615	COG1760	l-serine dehydratase
HL663_RS08625	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HL663_RS08640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HL663_RS08650	COG4176	ABC-type proline glycine betaine transport system permease component
HL663_RS08655	COG4175	Glycine betaine
HL663_RS08655	COG0517	IMP dehydrogenase activity
HL663_RS08660	COG1414	Transcriptional regulator
HL663_RS08665	COG5598	trimethylamine methyltransferase
HL663_RS08675	COG5012	cobalamin binding
HL663_RS08695	COG0646	methionine synthase
HL663_RS08695	COG1410	methionine synthase
HL663_RS08715	COG0583	DNA-binding transcription factor activity
HL663_RS08720	COG1192	Involved in chromosome partitioning
HL663_RS08725	COG1064	alcohol dehydrogenase
HL663_RS08730	COG0513	Belongs to the DEAD box helicase family
HL663_RS08740	COG2261	transglycosylase associated protein
HL663_RS08765	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HL663_RS08865	COG3480	Lon protease (S16) C-terminal proteolytic domain
HL663_RS08875	COG1615	UPF0182 protein
HL663_RS08885	COG1252	NADH dehydrogenase
HL663_RS08890	COG0612	Peptidase, M16
HL663_RS08900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HL663_RS08905	COG0483	inositol monophosphate 1-phosphatase activity
HL663_RS08910	COG4166	transmembrane transport
HL663_RS08915	COG0601	transmembrane transport
HL663_RS08920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HL663_RS08930	COG4608	Belongs to the ABC transporter superfamily
HL663_RS08935	COG1162	GTPase activity
HL663_RS08940	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HL663_RS08950	COG2135	peptidase activity
HL663_RS08960	COG1595	DNA-templated transcription, initiation
HL663_RS08965	COG5662	AntiSigma factor
HL663_RS09005	COG0765	amino acid transport
HL663_RS09025	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HL663_RS09040	COG0604	alcohol dehydrogenase
HL663_RS09055	COG0508	dehydrogenase complex catalyzes the overall conversion of
HL663_RS09055	COG0567	Dehydrogenase, E1 component
HL663_RS09070	COG1253	flavin adenine dinucleotide binding
HL663_RS09085	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HL663_RS09095	COG0745	RESPONSE REGULATOR receiver
HL663_RS09100	COG0018	arginyl-trna synthetase
HL663_RS09110	COG0460	homoserine dehydrogenase
HL663_RS09115	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HL663_RS09120	COG0083	homoserine kinase activity
HL663_RS09140	COG0254	rRNA binding
HL663_RS09145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HL663_RS09150	COG2890	protein-(glutamine-N5) methyltransferase activity
HL663_RS09155	COG0009	L-threonylcarbamoyladenylate synthase
HL663_RS09160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HL663_RS09165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HL663_RS09175	COG0356	it plays a direct role in the translocation of protons across the membrane
HL663_RS09180	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HL663_RS09185	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HL663_RS09190	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HL663_RS09195	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HL663_RS09200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HL663_RS09205	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HL663_RS09210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HL663_RS09230	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HL663_RS09230	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HL663_RS09235	COG0693	protein deglycase activity
HL663_RS09240	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HL663_RS09275	COG0604	alcohol dehydrogenase
HL663_RS09290	COG0183	Belongs to the thiolase family
HL663_RS09370	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HL663_RS09375	COG3281	Trehalose synthase
HL663_RS09380	COG0366	Alpha amylase catalytic
HL663_RS09385	COG0366	Alpha amylase catalytic
HL663_RS09390	COG0058	SHG alpha-glucan phosphorylase activity
HL663_RS09415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HL663_RS09445	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HL663_RS09455	COG0482	sulfurtransferase activity
HL663_RS09480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL663_RS09505	COG0318	PFAM AMP-dependent synthetase and ligase
HL663_RS09530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HL663_RS09565	COG2860	membrane
HL663_RS09570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HL663_RS09575	COG0154	amidase activity
HL663_RS09580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HL663_RS09595	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HL663_RS09595	COG2755	lipolytic protein G-D-S-L family
HL663_RS09605	COG2409	Drug exporters of the RND superfamily
HL663_RS09625	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HL663_RS09630	COG0129	dihydroxy-acid dehydratase activity
HL663_RS09655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HL663_RS09660	COG0028	Belongs to the TPP enzyme family
HL663_RS09665	COG0440	acetolactate synthase activity
HL663_RS09670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HL663_RS09680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL663_RS09695	COG0473	3-isopropylmalate dehydrogenase activity
HL663_RS09700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HL663_RS09705	COG0531	amino acid
HL663_RS09725	COG0174	glutamine synthetase
HL663_RS09730	COG1012	belongs to the aldehyde dehydrogenase family
HL663_RS09735	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_RS09740	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HL663_RS09760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HL663_RS09815	COG0179	Fumarylacetoacetate (FAA) hydrolase
HL663_RS09830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HL663_RS09865	COG1414	Transcriptional regulator
HL663_RS09870	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HL663_RS09875	COG0066	3-isopropylmalate dehydratase activity
HL663_RS09880	COG0776	regulation of translation
HL663_RS09885	COG1920	GTP binding
HL663_RS09895	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HL663_RS09905	COG1181	Belongs to the D-alanine--D-alanine ligase family
HL663_RS09925	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HL663_RS09930	COG1461	Dihydroxyacetone kinase
HL663_RS09935	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HL663_RS09940	COG0742	ribosomal rna small subunit methyltransferase
HL663_RS09950	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HL663_RS09955	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HL663_RS09955	COG2755	lipolytic protein G-D-S-L family
HL663_RS09965	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HL663_RS09970	COG0571	ribonuclease III activity
HL663_RS09975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HL663_RS09980	COG2755	lipolytic protein G-D-S-L family
HL663_RS09980	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HL663_RS09990	COG1605	Chorismate mutase
HL663_RS09990	COG0287	Prephenate dehydrogenase
HL663_RS10005	COG0681	Belongs to the peptidase S26 family
HL663_RS10015	COG3590	peptidase
HL663_RS10040	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HL663_RS10050	COG2267	carboxylic ester hydrolase activity
HL663_RS10060	COG0730	response to heat
HL663_RS10070	COG0228	four-way junction DNA binding
HL663_RS10075	COG1837	Belongs to the UPF0109 family
HL663_RS10080	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HL663_RS10085	COG0336	Belongs to the RNA methyltransferase TrmD family
HL663_RS10090	COG0390	transport system, permease component
HL663_RS10095	COG0335	large ribosomal subunit rRNA binding
HL663_RS10105	COG0681	Belongs to the peptidase S26 family
HL663_RS10110	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HL663_RS10120	COG1012	belongs to the aldehyde dehydrogenase family
HL663_RS10125	COG0792	nuclease activity
HL663_RS10140	COG4974	Belongs to the 'phage' integrase family
HL663_RS10160	COG0052	Belongs to the universal ribosomal protein uS2 family
HL663_RS10165	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HL663_RS10175	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HL663_RS10180	COG0528	UMP kinase activity
HL663_RS10185	COG0233	cytoplasmic translational termination
HL663_RS10200	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HL663_RS10215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HL663_RS10220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HL663_RS10230	COG1012	belongs to the aldehyde dehydrogenase family
HL663_RS10240	COG3842	ATPase activity
HL663_RS10245	COG1176	ABC-type spermidine putrescine transport system, permease component I
HL663_RS10250	COG1177	transmembrane transport
HL663_RS10270	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HL663_RS10275	COG0750	zinc metalloprotease
HL663_RS10285	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HL663_RS10300	COG4213	ABC transporter substrate-binding protein
HL663_RS10305	COG4214	carbohydrate transport
HL663_RS10310	COG1129	ABC transporter
HL663_RS10320	COG0442	prolyl-tRNA aminoacylation
HL663_RS10360	COG1331	Highly conserved protein containing a thioredoxin domain
HL663_RS10375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HL663_RS10390	COG3842	ATPase activity
HL663_RS10395	COG2010	Cytochrome c
HL663_RS10395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HL663_RS10415	COG0779	Required for maturation of 30S ribosomal subunits
HL663_RS10430	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HL663_RS10430	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HL663_RS10450	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HL663_RS10455	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HL663_RS10465	COG0772	Belongs to the SEDS family
HL663_RS10470	COG1022	Amp-dependent synthetase and ligase
HL663_RS10485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HL663_RS10520	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HL663_RS10530	COG1530	ribonuclease E activity
HL663_RS10535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HL663_RS10540	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HL663_RS10545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HL663_RS10550	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HL663_RS10555	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HL663_RS10560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HL663_RS10565	COG0463	Glycosyl transferase, family 2
HL663_RS10575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HL663_RS10580	COG0799	negative regulation of ribosome biogenesis
HL663_RS10585	COG0588	phosphoglycerate mutase activity
HL663_RS10600	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HL663_RS10605	COG2818	Glycosylase
HL663_RS10610	COG1408	metallophosphoesterase
HL663_RS10615	COG0386	Belongs to the glutathione peroxidase family
HL663_RS10640	COG0495	leucyl-tRNA aminoacylation
HL663_RS10645	COG3842	ATPase activity
HL663_RS10655	COG1176	ABC-type spermidine putrescine transport system, permease component I
HL663_RS10660	COG1177	transmembrane transport
HL663_RS10665	COG1228	amidohydrolase
HL663_RS10670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HL663_RS10705	COG2205	protein histidine kinase activity
HL663_RS10720	COG1307	EDD domain protein, DegV family
HL663_RS10725	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HL663_RS10730	COG1555	photosystem II stabilization
HL663_RS10730	COG1596	polysaccharide export
HL663_RS10740	COG0583	DNA-binding transcription factor activity
HL663_RS10745	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HL663_RS10750	COG1247	-acetyltransferase
HL663_RS10755	COG0189	ligase activity
HL663_RS10755	COG0569	domain protein
HL663_RS10760	COG4067	protein conserved in archaea
HL663_RS10760	COG0189	ligase activity
HL663_RS10770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HL663_RS10785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HL663_RS10800	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HL663_RS10805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HL663_RS10830	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HL663_RS10830	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HL663_RS10880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HL663_RS10885	COG1199	ATP-dependent helicase activity
HL663_RS10885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HL663_RS11065	COG0667	Aldo Keto reductase
HL663_RS11085	COG0702	epimerase
HL663_RS11090	COG1733	regulation of RNA biosynthetic process
HL663_RS11125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HL663_RS11130	COG2267	carboxylic ester hydrolase activity
HL663_RS11150	COG0667	Aldo Keto reductase
HL663_RS11170	COG1643	Atp-dependent helicase
HL663_RS11190	COG3339	Conserved Protein
HL663_RS11200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HL663_RS11205	COG0589	response to stress
HL663_RS11210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HL663_RS11215	COG1305	Transglutaminase-like
HL663_RS11225	COG0714	Associated with various cellular activities
HL663_RS11230	COG2001	Belongs to the MraZ family
HL663_RS11235	COG0275	rRNA processing
HL663_RS11245	COG0768	penicillin binding
HL663_RS11250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HL663_RS11260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HL663_RS11265	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HL663_RS11275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HL663_RS11280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HL663_RS11285	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HL663_RS11290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HL663_RS11300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HL663_RS11305	COG1799	cell septum assembly
HL663_RS11315	COG3599	regulation of cell shape
HL663_RS11325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HL663_RS11335	COG0587	DNA-directed DNA polymerase activity
HL663_RS11340	COG0737	Belongs to the 5'-nucleotidase family
HL663_RS11340	COG1525	nuclease
HL663_RS11340	COG4085	toxin activity
HL663_RS11360	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HL663_RS11360	COG0235	Class ii aldolase
HL663_RS11390	COG0640	Transcriptional regulator
HL663_RS11400	COG0746	molybdenum cofactor guanylyltransferase activity
HL663_RS11415	COG0438	transferase activity, transferring glycosyl groups
HL663_RS11425	COG1132	(ABC) transporter
HL663_RS11450	COG1609	Transcriptional regulator
HL663_RS11455	COG3250	beta-galactosidase activity
HL663_RS11465	COG2508	Transcriptional regulator
HL663_RS11470	COG2072	flavoprotein involved in K transport
HL663_RS11475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HL663_RS11485	COG2186	Transcriptional regulator
HL663_RS11495	COG1070	Carbohydrate kinase
HL663_RS11500	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_RS11500	COG3347	Dehydrogenase
HL663_RS11515	COG0174	glutamine synthetase
HL663_RS11530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HL663_RS11535	COG0321	lipoyl(octanoyl) transferase activity
HL663_RS11540	COG2409	Drug exporters of the RND superfamily
HL663_RS11545	COG0673	inositol 2-dehydrogenase activity
HL663_RS11550	COG3340	Belongs to the peptidase S51 family
HL663_RS11560	COG1090	epimerase
HL663_RS11565	COG0508	dehydrogenase complex catalyzes the overall conversion of
HL663_RS11570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HL663_RS11585	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HL663_RS11590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HL663_RS11610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HL663_RS11615	COG0435	Glutathione S-transferase
HL663_RS11630	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HL663_RS11635	COG2318	DinB family
HL663_RS11640	COG1929	Belongs to the glycerate kinase type-1 family
HL663_RS11650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL663_RS11655	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HL663_RS11660	COG0425	Belongs to the sulfur carrier protein TusA family
HL663_RS11665	COG1104	cysteine desulfurase activity
HL663_RS11670	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HL663_RS11675	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HL663_RS11695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HL663_RS11700	COG0723	plastoquinol--plastocyanin reductase activity
HL663_RS11705	COG2010	Cytochrome c
HL663_RS11710	COG1845	cytochrome c oxidase, subunit III
HL663_RS11715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HL663_RS11760	COG1022	Amp-dependent synthetase and ligase
HL663_RS11775	COG1940	carbohydrate kinase activity
HL663_RS11810	COG2197	response regulator
HL663_RS11815	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HL663_RS11835	COG1388	LysM domain
HL663_RS11835	COG3942	CHAP domain
HL663_RS11880	COG0587	DNA-directed DNA polymerase activity
HL663_RS11890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HL663_RS11910	COG0187	DNA topoisomerase II activity
HL663_RS11920	COG1609	Transcriptional regulator
HL663_RS11925	COG0395	ABC-type sugar transport system, permease component
HL663_RS11930	COG1175	transmembrane transport
HL663_RS11935	COG1653	transport
HL663_RS11940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HL663_RS11950	COG0045	succinate-CoA ligase (ADP-forming) activity
HL663_RS11950	COG1042	CoA-binding domain protein
HL663_RS11950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HL663_RS11965	COG1435	thymidine kinase activity
HL663_RS12015	COG0569	domain protein
HL663_RS12020	COG0531	amino acid
HL663_RS12025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HL663_RS12035	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HL663_RS12040	COG0395	ABC-type sugar transport system, permease component
HL663_RS12045	COG1175	transmembrane transport
HL663_RS12055	COG1609	Transcriptional regulator
HL663_RS12065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HL663_RS12075	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HL663_RS12125	COG0346	lactoylglutathione lyase activity
HL663_RS12175	COG1733	regulation of RNA biosynthetic process
HL663_RS12205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HL663_RS12210	COG1024	Enoyl-CoA hydratase
HL663_RS12210	COG1250	3-hydroxyacyl-CoA dehydrogenase
HL663_RS12215	COG0183	Belongs to the thiolase family
HL663_RS12240	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HL663_RS12275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HL663_RS12280	COG1793	dna ligase
HL663_RS12295	COG2326	polyphosphate kinase activity
HL663_RS12400	COG3842	ATPase activity
HL663_RS12405	COG4208	sulfate ABC transporter
HL663_RS12420	COG5001	Diguanylate cyclase
HL663_RS12445	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HL663_RS12450	COG0512	Glutamine amidotransferase of anthranilate synthase
HL663_RS12450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HL663_RS12480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HL663_RS12490	COG0183	Belongs to the thiolase family
HL663_RS12525	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HL663_RS12540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HL663_RS12565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HL663_RS12575	COG0438	transferase activity, transferring glycosyl groups
HL663_RS12585	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HL663_RS12590	COG0477	Major facilitator Superfamily
HL663_RS12600	COG3706	GGDEF domain
HL663_RS12610	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HL663_RS12615	COG0217	transcriptional regulatory protein
HL663_RS12620	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HL663_RS12625	COG0632	four-way junction helicase activity
HL663_RS12630	COG2255	four-way junction helicase activity
HL663_RS12640	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HL663_RS12645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HL663_RS12650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HL663_RS12655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HL663_RS12660	COG1196	nuclear chromosome segregation
HL663_RS12665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HL663_RS12675	COG0124	histidyl-tRNA synthetase
HL663_RS12685	COG0686	Belongs to the AlaDH PNT family
HL663_RS12700	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HL663_RS12705	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HL663_RS12720	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HL663_RS12725	COG1160	GTP binding
HL663_RS12735	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HL663_RS12765	COG1716	ATPase activity
HL663_RS12785	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HL663_RS12785	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HL663_RS12790	COG0419	ATPase involved in DNA repair
HL663_RS12795	COG0420	3'-5' exonuclease activity
HL663_RS12805	COG0406	alpha-ribazole phosphatase activity
HL663_RS12815	COG0009	L-threonylcarbamoyladenylate synthase
HL663_RS12825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HL663_RS12840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HL663_RS12870	COG1216	Glycosyl transferase, family 2
HL663_RS12880	COG1607	acyl-coa hydrolase
HL663_RS12885	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HL663_RS12890	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HL663_RS12895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HL663_RS12930	COG0604	alcohol dehydrogenase
HL663_RS12935	COG1509	lysine 2,3-aminomutase activity
HL663_RS12940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HL663_RS12950	COG0492	ferredoxin-NADP+ reductase activity
HL663_RS12955	COG1522	sequence-specific DNA binding
HL663_RS12960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HL663_RS12990	COG0805	protein transport
HL663_RS12995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HL663_RS13005	COG2378	regulation of single-species biofilm formation
HL663_RS13030	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HL663_RS13035	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HL663_RS13040	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HL663_RS13050	COG4122	O-methyltransferase activity
HL663_RS13060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HL663_RS13075	COG1222	aaa ATPase
HL663_RS13085	COG0517	IMP dehydrogenase activity
HL663_RS13085	COG1994	Peptidase M50
HL663_RS13090	COG0646	methionine synthase
HL663_RS13090	COG1410	methionine synthase
HL663_RS13100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL663_RS13110	COG0215	cysteine-tRNA ligase activity
HL663_RS13125	COG1122	ATPase activity
HL663_RS13145	COG0588	phosphoglycerate mutase activity
HL663_RS13150	COG0598	Magnesium transport protein CorA
HL663_RS13155	COG1968	undecaprenyl-diphosphatase activity
HL663_RS13160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_RS13170	COG1090	epimerase
HL663_RS13175	COG0667	Aldo Keto reductase
HL663_RS13190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HL663_RS13200	COG0515	serine threonine protein kinase
HL663_RS13215	COG2205	protein histidine kinase activity
HL663_RS13215	COG0784	Response regulator, receiver
HL663_RS13230	COG0745	RESPONSE REGULATOR receiver
HL663_RS13260	COG1119	ATPase activity
HL663_RS13270	COG0297	glycogen (starch) synthase activity
HL663_RS13295	COG0560	Phosphoserine phosphatase
HL663_RS13295	COG3830	Belongs to the UPF0237 family
HL663_RS13305	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_RS13315	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HL663_RS13330	COG1132	(ABC) transporter
HL663_RS13335	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HL663_RS13340	COG0488	(ABC) transporter
HL663_RS13370	COG2151	metal-sulfur cluster biosynthetic enzyme
HL663_RS13375	COG0822	iron-sulfur transferase activity
HL663_RS13385	COG0396	ATPase activity
HL663_RS13410	COG1183	phosphatidylcholine synthase activity
HL663_RS13440	COG0109	protoheme IX farnesyltransferase activity
HL663_RS13450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HL663_RS13455	COG0166	Belongs to the GPI family
HL663_RS13470	COG0363	glucosamine-6-phosphate deaminase activity
HL663_RS13485	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HL663_RS13490	COG0149	triose-phosphate isomerase activity
HL663_RS13495	COG0126	phosphoglycerate kinase activity
HL663_RS13500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HL663_RS13505	COG1481	regulation of sporulation
HL663_RS13510	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HL663_RS13515	COG1660	Displays ATPase and GTPase activities
HL663_RS13520	COG0322	excinuclease ABC activity
HL663_RS13560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HL663_RS13565	COG3387	PFAM Glycoside hydrolase 15-related
HL663_RS13575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL663_RS13580	COG5006	permease, DMT superfamily
HL663_RS13590	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HL663_RS13605	COG0667	Aldo Keto reductase
HL663_RS13610	COG0556	nucleotide-excision repair
HL663_RS13615	COG1940	carbohydrate kinase activity
HL663_RS13630	COG3833	ABC-type maltose transport systems, permease component
HL663_RS13640	COG0531	amino acid
HL663_RS13645	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HL663_RS13645	COG0237	dephospho-CoA kinase activity
HL663_RS13660	COG3467	pyridoxamine 5'-phosphate
HL663_RS13665	COG3842	ATPase activity
HL663_RS13675	COG0395	ABC-type sugar transport system, permease component
HL663_RS13685	COG0539	negative regulation of cytoplasmic translation
HL663_RS13690	COG2226	methyltransferase
HL663_RS13710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HL663_RS13750	COG2050	protein possibly involved in aromatic compounds catabolism
HL663_RS13780	COG0469	pyruvate kinase activity
HL663_RS13790	COG0070	glutamate synthase
HL663_RS13790	COG0069	glutamate synthase activity
HL663_RS13790	COG0067	glutamate synthase
HL663_RS13810	COG0159	tryptophan synthase activity
HL663_RS13815	COG0133	tryptophan synthase activity
HL663_RS13820	COG0134	indole-3-glycerol-phosphate synthase activity
HL663_RS13840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HL663_RS13870	COG0107	imidazoleglycerol-phosphate synthase activity
HL663_RS13875	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HL663_RS13880	COG4129	membrane
HL663_RS13885	COG2807	transmembrane transport
HL663_RS13895	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HL663_RS13900	COG0140	phosphoribosyl-ATP diphosphatase activity
HL663_RS13905	COG3201	nicotinamide mononucleotide transporter
HL663_RS13910	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HL663_RS13915	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HL663_RS13915	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HL663_RS13935	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HL663_RS13955	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HL663_RS13965	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HL663_RS13985	COG1758	RNA polymerase activity
HL663_RS13990	COG0194	GDP metabolic process
HL663_RS14000	COG0284	orotidine-5'-phosphate decarboxylase activity
HL663_RS14005	COG0167	dihydroorotate dehydrogenase activity
HL663_RS14010	COG0543	2 iron, 2 sulfur cluster binding
HL663_RS14015	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HL663_RS14020	COG0505	Belongs to the CarA family
HL663_RS14025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HL663_RS14030	COG0540	Belongs to the ATCase OTCase family
HL663_RS14035	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HL663_RS14060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HL663_RS14065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HL663_RS14075	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HL663_RS14080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HL663_RS14085	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HL663_RS14095	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HL663_RS14100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HL663_RS14105	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HL663_RS14110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HL663_RS14145	COG2267	carboxylic ester hydrolase activity
HL663_RS14150	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HL663_RS14170	COG3012	SEC-C Motif Domain Protein
HL663_RS14180	COG0504	CTP synthase activity
HL663_RS14210	COG0497	DNA recombination
HL663_RS14215	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HL663_RS14235	COG0647	UMP catabolic process
HL663_RS14260	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HL663_RS14265	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HL663_RS14270	COG2094	Belongs to the DNA glycosylase MPG family
HL663_RS14275	COG0165	Argininosuccinate lyase
HL663_RS14280	COG1438	arginine binding
HL663_RS14285	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HL663_RS14290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HL663_RS14295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HL663_RS14300	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HL663_RS14310	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HL663_RS14320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HL663_RS14320	COG0072	phenylalanine-tRNA ligase activity
HL663_RS14325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HL663_RS14345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HL663_RS14350	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HL663_RS14355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HL663_RS14360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HL663_RS14375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HL663_RS14380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HL663_RS14390	COG0131	Imidazoleglycerol-phosphate dehydratase
HL663_RS14395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HL663_RS14400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HL663_RS14415	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HL663_RS14425	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HL663_RS14430	COG0174	glutamine synthetase
HL663_RS14450	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HL663_RS14470	COG1940	carbohydrate kinase activity
HL663_RS14525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HL663_RS14550	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HL663_RS14580	COG2267	carboxylic ester hydrolase activity
HL663_RS14585	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HL663_RS14590	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HL663_RS14625	COG1404	Belongs to the peptidase S8 family
HL663_RS14630	COG0137	argininosuccinate synthase activity
HL663_RS14645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HL663_RS14650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HL663_RS14655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HL663_RS14675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HL663_RS14675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL663_RS14685	COG0730	response to heat
HL663_RS14700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HL663_RS14710	COG1126	abc transporter atp-binding protein
HL663_RS14715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL663_RS14720	COG0765	amino acid transport
HL663_RS14725	COG0765	amino acid transport
HL663_RS14745	COG5002	protein histidine kinase activity
HL663_RS14750	COG0745	RESPONSE REGULATOR receiver
HL663_RS14755	COG5002	protein histidine kinase activity
HL663_RS14770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_RS14775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL663_RS14810	COG0673	inositol 2-dehydrogenase activity
HL663_RS14815	COG0444	Belongs to the ABC transporter superfamily
HL663_RS14825	COG0601	transmembrane transport
HL663_RS14830	COG0747	negative chemotaxis
HL663_RS14835	COG4608	Belongs to the ABC transporter superfamily
HL663_RS14845	COG0436	Aminotransferase
HL663_RS14850	COG1028	Short-chain dehydrogenase reductase Sdr
HL663_RS14875	COG0582	viral genome integration into host DNA
HL663_RS14895	COG0438	transferase activity, transferring glycosyl groups
HL663_RS14975	COG0358	DNA primase activity
HL663_RS15010	COG0739	heme binding
HL663_RS15010	COG0741	lytic transglycosylase activity
HL663_RS15010	COG1196	nuclear chromosome segregation
HL663_RS15070	COG0741	lytic transglycosylase activity
HL663_RS15070	COG1388	LysM domain
HL663_RS15140	COG0419	ATPase involved in DNA repair
HL663_RS15190	COG1063	alcohol dehydrogenase
HL663_RS15215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL663_RS15265	COG0358	DNA primase activity
HL663_RS15270	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HL663_RS15320	COG1253	flavin adenine dinucleotide binding
HL663_RS15325	COG0423	glycine-tRNA ligase activity
HL663_RS15335	COG0803	Belongs to the bacterial solute-binding protein 9 family
HL663_RS15340	COG1121	(ABC) transporter
HL663_RS15345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HL663_RS15355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HL663_RS15395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HL663_RS15405	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HL663_RS15430	COG2197	response regulator
HL663_RS15450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HL663_RS15460	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HL663_RS15470	COG0537	adenosine 5'-monophosphoramidase activity
HL663_RS15495	COG0484	heat shock protein binding
HL663_RS15500	COG1420	regulation of RNA biosynthetic process
HL663_RS15535	COG1051	belongs to the nudix hydrolase family
HL663_RS15550	COG3629	intracellular signal transduction
HL663_RS15565	COG2197	response regulator
HL663_RS15570	COG2132	Multicopper oxidase
HL663_RS15595	COG0481	GTPase activity
HL663_RS15620	COG0268	Binds directly to 16S ribosomal RNA
HL663_RS15650	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HL663_RS15660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HL663_RS15665	COG2813	Specifically methylates the guanine in position
HL663_RS15670	COG0405	Gamma-glutamyltransferase
HL663_RS15675	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HL663_RS15680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HL663_RS15685	COG0242	peptide deformylase activity
HL663_RS15700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL663_RS15710	COG1305	Transglutaminase-like
HL663_RS15730	COG1278	Cold shock
HL663_RS15750	COG3304	Inner membrane component domain
HL663_RS15760	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HL663_RS15810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HL663_RS15815	COG2957	Belongs to the agmatine deiminase family
HL663_RS15835	COG1201	RNA secondary structure unwinding
HL663_RS15840	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HL663_RS15845	COG1396	sequence-specific DNA binding
HL663_RS15850	COG1546	Belongs to the CinA family
HL663_RS15850	COG1058	Belongs to the CinA family
HL663_RS15860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL663_RS15875	COG1674	ftsk spoiiie
HL663_RS15880	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HL663_RS15885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HL663_RS15890	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HL663_RS15930	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HL663_RS15930	COG1648	precorrin-2 dehydrogenase activity
HL663_RS15935	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HL663_RS15945	COG1185	polyribonucleotide nucleotidyltransferase activity
HL663_RS15950	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HL663_RS15980	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HL663_RS15990	COG3383	formate dehydrogenase (NAD+) activity
HL663_RS16040	COG3973	AAA domain
HL663_RS16040	COG3973	AAA domain
HL663_RS16080	COG0438	transferase activity, transferring glycosyl groups
HL663_RS16085	COG0463	Glycosyl transferase, family 2
HL663_RS16090	COG0110	maltose O-acetyltransferase activity
HL663_RS16095	COG1216	Glycosyl transferase, family 2
HL663_RS16120	COG0768	penicillin binding
HL663_RS16140	COG0105	UTP biosynthetic process
HL663_RS16155	COG1131	(ABC) transporter
HL663_RS16165	COG4585	Histidine kinase
HL663_RS16170	COG2197	response regulator
HL663_RS16175	COG0285	dihydrofolate synthase activity
HL663_RS16220	COG3845	ABC transporter
HL663_RS16245	COG0204	Acyl-transferase
HL663_RS16250	COG1674	ftsk spoiiie
HL663_RS16295	COG1404	Belongs to the peptidase S8 family
HL663_RS16300	COG0525	valine-tRNA ligase activity
HL663_RS16325	COG0714	Associated with various cellular activities
HL663_RS16340	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HL663_RS16355	COG0740	serine-type endopeptidase activity
HL663_RS16360	COG0740	serine-type endopeptidase activity
HL663_RS16365	COG0738	Major facilitator superfamily
HL663_RS16370	COG1609	Transcriptional regulator
HL663_RS16375	COG0544	peptidyl-prolyl cis-trans isomerase activity
HL663_RS16395	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HL663_RS16405	COG0698	ribose 5-phosphate isomerase
HL663_RS16410	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HL663_RS16420	COG0668	transmembrane transport
HL663_RS16430	COG0366	Alpha amylase catalytic
HL663_RS16460	COG0514	ATP-dependent DNA helicase (RecQ)
HL663_RS16470	COG0477	Major facilitator Superfamily
HL663_RS16480	COG2364	Membrane
HL663_RS16485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL663_RS16490	COG1946	Acyl-CoA thioesterase
HL663_RS16495	COG1136	(ABC) transporter
HL663_RS16495	COG0577	efflux transmembrane transporter activity
HL663_RS16500	COG1136	(ABC) transporter
HL663_RS16535	COG1960	acyl-CoA dehydrogenase activity
HL663_RS16540	COG1309	transcriptional regulator
HL663_RS16545	COG2226	methyltransferase
HL663_RS16555	COG0463	Glycosyl transferase, family 2
HL663_RS16565	COG0629	single-stranded DNA binding
HL663_RS16570	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HL663_RS16590	COG1473	amidohydrolase
HL663_RS16600	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HL663_RS16665	COG2197	response regulator
HL663_RS16670	COG4585	Histidine kinase
HL663_RS16740	COG1742	UPF0060 membrane protein
HL663_RS16755	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HL663_RS16770	COG5640	endopeptidase activity
HL663_RS16780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HL663_RS16785	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HL663_RS16790	COG1234	tRNA 3'-trailer cleavage
HL663_RS16795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HL663_RS16805	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HL663_RS16860	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HL663_RS16865	COG1522	sequence-specific DNA binding
HL663_RS16870	COG0737	Belongs to the 5'-nucleotidase family
HL663_RS16890	COG1678	Uncharacterized ACR, COG1678
HL663_RS16895	COG0513	Belongs to the DEAD box helicase family
HL663_RS16935	COG3237	CsbD-like
HL663_RS16945	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HL663_RS16950	COG0739	heme binding
HL663_RS16950	COG0741	lytic transglycosylase activity
HL663_RS16950	COG1196	nuclear chromosome segregation
HL663_RS16955	COG2177	Part of the ABC transporter FtsEX involved in
HL663_RS16960	COG2884	Cell division ATP-binding protein ftsE
HL663_RS16975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HL663_RS16985	COG3265	gluconokinase activity
HL663_RS16990	COG2186	Transcriptional regulator
HL663_RS17035	COG1674	ftsk spoiiie
HL663_RS17060	COG2902	Dehydrogenase
HL663_RS17065	COG1982	Orn Lys Arg decarboxylase major
HL663_RS17090	COG1012	belongs to the aldehyde dehydrogenase family
HL663_RS17135	COG0653	protein targeting
HL663_RS17150	COG2197	response regulator
HL663_RS17155	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HL663_RS17165	COG5401	PFAM Sporulation and spore germination
HL663_RS17170	COG5000	phosphorelay sensor kinase activity
HL663_RS17170	COG5002	protein histidine kinase activity
HL663_RS17175	COG0745	RESPONSE REGULATOR receiver
HL663_RS17205	COG2894	cell division
HL663_RS17260	COG4106	trans-aconitate 2-methyltransferase activity
HL663_RS17275	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HL663_RS17300	COG3903	Transcriptional regulator
HL663_RS17300	COG3629	intracellular signal transduction
HL663_RS17305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HL663_RS17350	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HL663_RS17355	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HL663_RS17355	COG0778	Nitroreductase
HL663_RS17375	COG0438	transferase activity, transferring glycosyl groups
HL663_RS17395	COG1695	Transcriptional regulator
HL663_RS17420	COG2385	sporulation resulting in formation of a cellular spore
HL663_RS17425	COG2247	cell wall binding repeat
HL663_RS17425	COG0860	N-Acetylmuramoyl-L-alanine amidase
HL663_RS17445	COG1134	teichoic acid transport
HL663_RS17475	COG2755	lipolytic protein G-D-S-L family
HL663_RS17475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HL663_RS17480	COG1215	transferase activity, transferring glycosyl groups
HL663_RS17490	COG1216	Glycosyl transferase, family 2
HL663_RS17505	COG1316	TRANSCRIPTIONal
HL663_RS17510	COG1316	TRANSCRIPTIONal
HL663_RS17535	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HL663_RS17560	COG4585	Histidine kinase
HL663_RS17585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL663_RS17620	COG0745	RESPONSE REGULATOR receiver
HL663_RS17635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HL663_RS17650	COG2258	MOSC domain
HL663_RS17660	COG1309	transcriptional regulator
HL663_RS17670	COG0424	maF-like protein
HL663_RS17685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HL663_RS17690	COG1960	acyl-CoA dehydrogenase activity
HL663_RS17705	COG3483	tryptophan 2,3-dioxygenase activity
HL663_RS17720	COG1609	Transcriptional regulator
HL663_RS17740	COG0697	spore germination
HL663_RS17745	COG1846	Transcriptional regulator
HL663_RS17750	COG4770	biotin carboxylase activity
HL663_RS17785	COG3842	ATPase activity
HL663_RS17805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HL663_RS17810	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HL663_RS17815	COG1012	belongs to the aldehyde dehydrogenase family
HL663_RS17820	COG1012	belongs to the aldehyde dehydrogenase family
HL663_RS17855	COG0714	Associated with various cellular activities
HL663_RS17875	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HL663_RS17875	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HL663_RS17890	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HL663_RS17915	COG1131	(ABC) transporter
HL663_RS17935	COG0438	transferase activity, transferring glycosyl groups
HL663_RS17945	COG0180	Tryptophanyl-tRNA synthetase
HL663_RS17950	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HL663_RS17965	COG2895	sulfate adenylyltransferase (ATP) activity
HL663_RS17965	COG0529	Catalyzes the synthesis of activated sulfate
HL663_RS17970	COG0730	response to heat
HL663_RS17995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HL663_RS18015	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HL663_RS18035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HL663_RS18055	COG2838	Isocitrate dehydrogenase
HL663_RS18065	COG0039	L-malate dehydrogenase activity
HL663_RS18070	COG0387	Pfam Sodium calcium exchanger
HL663_RS18075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HL663_RS18080	COG1304	FMN binding
HL663_RS18085	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HL663_RS18110	COG2233	PERMEase
HL663_RS18150	COG2268	Band 7 protein
HL663_RS18180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HL663_RS18195	COG0549	Belongs to the carbamate kinase family
HL663_RS18220	COG2116	formate transmembrane transporter activity
HL663_RS18225	COG0138	bifunctional purine biosynthesis protein purh
HL663_RS18260	COG0045	succinate-CoA ligase (ADP-forming) activity
HL663_RS18270	COG0596	Alpha beta hydrolase
HL663_RS18300	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HL663_RS18305	COG3104	oligopeptide transport
HL663_RS18335	COG2197	response regulator
HL663_RS18365	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HL663_RS18375	COG1362	aminopeptidase activity
HL663_RS18390	COG2267	carboxylic ester hydrolase activity
HL663_RS18395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HL663_RS18395	COG0519	Catalyzes the synthesis of GMP from XMP
HL663_RS18415	COG1132	(ABC) transporter
HL663_RS18420	COG1132	(ABC) transporter
HL663_RS18425	COG0586	Pfam SNARE associated Golgi protein
HL663_RS18445	COG1012	belongs to the aldehyde dehydrogenase family
HL663_RS18450	COG0516	GMP reductase activity
HL663_RS18455	COG0477	Major facilitator Superfamily
HL663_RS18460	COG3191	aminopeptidase activity
HL663_RS18490	COG1136	(ABC) transporter
HL663_RS18500	COG1794	racemase activity, acting on amino acids and derivatives
HL663_RS18505	COG0459	protein refolding
HL663_RS18510	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HL663_RS18525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL663_RS18530	COG1957	nucleoside hydrolase
HL663_RS18545	COG2304	oxidoreductase activity
HL663_RS18555	COG0739	heme binding
HL663_RS18585	COG2226	methyltransferase
HL663_RS18610	COG2226	methyltransferase
HL663_RS18665	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HL663_RS18675	COG0456	acetyltransferase
HL663_RS18675	COG1214	PFAM Peptidase M22, glycoprotease
HL663_RS18680	COG0802	atpase or kinase
HL663_RS18690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HL663_RS18700	COG0736	holo-[acyl-carrier-protein] synthase activity
HL663_RS18705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HL663_RS18710	COG1072	(Pantothenic acid kinase))
HL663_RS18720	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HL663_RS18725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HL663_RS18740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HL663_RS18750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HL663_RS18790	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HL663_RS18800	COG0477	Major facilitator Superfamily
HL663_RS18815	COG0463	Glycosyl transferase, family 2
HL663_RS18840	COG1473	amidohydrolase
HL663_RS18840	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HL663_RS18845	COG0446	pyridine nucleotide-disulphide oxidoreductase
HL663_RS18845	COG1902	pentaerythritol trinitrate reductase activity
HL663_RS18860	COG2755	lipolytic protein G-D-S-L family
HL663_RS18865	COG0251	oxidation-reduction process
HL663_RS18910	COG0148	phosphopyruvate hydratase activity
HL663_RS18915	COG2313	pseudouridylate synthase activity
HL663_RS18920	COG1522	sequence-specific DNA binding
HL663_RS18920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL663_RS18955	COG0438	transferase activity, transferring glycosyl groups
HL663_RS19020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HL663_RS19025	COG0193	aminoacyl-tRNA hydrolase activity
HL663_RS19030	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HL663_RS19045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HL663_RS19050	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HL663_RS19055	COG2814	Major facilitator Superfamily