locus-tag	class	description
LDO15_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LDO15_RS00010	COG0592	DNA-directed DNA polymerase activity
LDO15_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LDO15_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LDO15_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
LDO15_RS00030	COG0187	DNA topoisomerase II activity
LDO15_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LDO15_RS00040	COG3266	domain, Protein
LDO15_RS00070	COG1215	transferase activity, transferring glycosyl groups
LDO15_RS00085	COG0705	Rhomboid family
LDO15_RS00090	COG0519	Catalyzes the synthesis of GMP from XMP
LDO15_RS00110	COG0515	serine threonine protein kinase
LDO15_RS00115	COG0515	serine threonine protein kinase
LDO15_RS00120	COG0768	penicillin binding
LDO15_RS00135	COG1716	ATPase activity
LDO15_RS00140	COG1716	ATPase activity
LDO15_RS00155	COG1116	anion transmembrane transporter activity
LDO15_RS00165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDO15_RS00240	COG0831	urea catabolic process
LDO15_RS00245	COG0832	Belongs to the urease beta subunit family
LDO15_RS00250	COG0804	urea catabolic process
LDO15_RS00255	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LDO15_RS00260	COG0830	nickel cation binding
LDO15_RS00265	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LDO15_RS00270	COG0829	nickel cation binding
LDO15_RS00275	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LDO15_RS00280	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LDO15_RS00300	COG0395	ABC-type sugar transport system, permease component
LDO15_RS00305	COG1175	transmembrane transport
LDO15_RS00315	COG1609	Transcriptional regulator
LDO15_RS00320	COG2186	Transcriptional regulator
LDO15_RS00325	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LDO15_RS00330	COG0477	Major facilitator Superfamily
LDO15_RS00335	COG1984	allophanate hydrolase subunit 2
LDO15_RS00340	COG4770	biotin carboxylase activity
LDO15_RS00360	COG0402	S-adenosylhomocysteine deaminase activity
LDO15_RS00365	COG4608	Belongs to the ABC transporter superfamily
LDO15_RS00370	COG0444	Belongs to the ABC transporter superfamily
LDO15_RS00375	COG0601	transmembrane transport
LDO15_RS00385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO15_RS00395	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LDO15_RS00455	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LDO15_RS00460	COG0574	Belongs to the PEP-utilizing enzyme family
LDO15_RS00460	COG3848	Pyruvate phosphate dikinase
LDO15_RS00480	COG2814	Major facilitator Superfamily
LDO15_RS00485	COG1280	lysine exporter protein (LysE YggA)
LDO15_RS00515	COG2814	Major facilitator Superfamily
LDO15_RS00545	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LDO15_RS00555	COG0069	glutamate synthase activity
LDO15_RS00575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO15_RS00585	COG1012	belongs to the aldehyde dehydrogenase family
LDO15_RS00590	COG0596	Alpha beta hydrolase
LDO15_RS00605	COG1802	Transcriptional regulator
LDO15_RS00625	COG0196	riboflavin kinase activity
LDO15_RS00655	COG3458	cephalosporin-C deacetylase activity
LDO15_RS00670	COG0363	glucosamine-6-phosphate deaminase activity
LDO15_RS00675	COG0402	S-adenosylhomocysteine deaminase activity
LDO15_RS00680	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
LDO15_RS00685	COG1940	carbohydrate kinase activity
LDO15_RS00690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDO15_RS00695	COG4608	Belongs to the ABC transporter superfamily
LDO15_RS00700	COG0444	Belongs to the ABC transporter superfamily
LDO15_RS00720	COG1760	l-serine dehydratase
LDO15_RS00745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LDO15_RS00750	COG1802	Transcriptional regulator
LDO15_RS00775	COG1012	belongs to the aldehyde dehydrogenase family
LDO15_RS00780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDO15_RS00790	COG2271	Major facilitator Superfamily
LDO15_RS00795	COG1802	Transcriptional regulator
LDO15_RS00800	COG0477	Major facilitator Superfamily
LDO15_RS00845	COG1177	transmembrane transport
LDO15_RS00850	COG3842	ATPase activity
LDO15_RS00855	COG1414	Transcriptional regulator
LDO15_RS00865	COG0574	Belongs to the PEP-utilizing enzyme family
LDO15_RS00865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LDO15_RS00910	COG1064	alcohol dehydrogenase
LDO15_RS00940	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LDO15_RS01005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO15_RS01010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO15_RS01035	COG0765	amino acid transport
LDO15_RS01050	COG1609	Transcriptional regulator
LDO15_RS01055	COG0385	Bile acid
LDO15_RS01060	COG0789	Transcriptional regulator
LDO15_RS01065	COG0659	secondary active sulfate transmembrane transporter activity
LDO15_RS01070	COG1609	Transcriptional regulator
LDO15_RS01075	COG0673	inositol 2-dehydrogenase activity
LDO15_RS01095	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LDO15_RS01105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LDO15_RS01105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDO15_RS01125	COG0561	phosphatase activity
LDO15_RS01135	COG0584	glycerophosphoryl diester phosphodiesterase
LDO15_RS01140	COG1929	Belongs to the glycerate kinase type-1 family
LDO15_RS01155	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS01165	COG2233	PERMEase
LDO15_RS01170	COG1473	amidohydrolase
LDO15_RS01175	COG0778	Nitroreductase
LDO15_RS01205	COG3104	oligopeptide transport
LDO15_RS01220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LDO15_RS01220	COG0425	Belongs to the sulfur carrier protein TusA family
LDO15_RS01235	COG1597	lipid kinase activity
LDO15_RS01240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LDO15_RS01245	COG0561	phosphatase activity
LDO15_RS01265	COG2027	D-alanyl-D-alanine carboxypeptidase
LDO15_RS01275	COG0037	tRNA processing
LDO15_RS01285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDO15_RS01290	COG0302	gtp cyclohydrolase
LDO15_RS01295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LDO15_RS01330	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LDO15_RS01335	COG2814	Major facilitator Superfamily
LDO15_RS01345	COG1435	thymidine kinase activity
LDO15_RS01355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LDO15_RS01375	COG0823	Involved in the tonB-independent uptake of proteins
LDO15_RS01375	COG1506	peptidase
LDO15_RS01380	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LDO15_RS01390	COG2376	Dihydroxyacetone kinase
LDO15_RS01395	COG1461	Dihydroxyacetone kinase
LDO15_RS01400	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LDO15_RS01420	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LDO15_RS01425	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LDO15_RS01430	COG2815	serine threonine protein kinase
LDO15_RS01430	COG0515	serine threonine protein kinase
LDO15_RS01450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LDO15_RS01455	COG2217	Heavy metal translocating P-type atpase
LDO15_RS01460	COG2132	Multicopper oxidase
LDO15_RS01480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LDO15_RS01495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LDO15_RS01500	COG0306	phosphate transporter
LDO15_RS01530	COG0515	serine threonine protein kinase
LDO15_RS01530	COG2815	serine threonine protein kinase
LDO15_RS01575	COG2890	protein-(glutamine-N5) methyltransferase activity
LDO15_RS01590	COG0667	Aldo Keto reductase
LDO15_RS01595	COG3360	Dodecin
LDO15_RS01605	COG1937	Protein conserved in bacteria
LDO15_RS01610	COG2186	Transcriptional regulator
LDO15_RS01620	COG2084	Dehydrogenase
LDO15_RS01625	COG2610	gluconate transmembrane transporter activity
LDO15_RS01660	COG0477	Major facilitator Superfamily
LDO15_RS01670	COG3285	dna ligase
LDO15_RS01670	COG1793	dna ligase
LDO15_RS01675	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LDO15_RS01690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDO15_RS01690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LDO15_RS01690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LDO15_RS01695	COG1105	Belongs to the carbohydrate kinase PfkB family
LDO15_RS01700	COG1349	DNA-binding transcription factor activity
LDO15_RS01715	COG1609	Transcriptional regulator
LDO15_RS01740	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LDO15_RS01750	COG1140	nitrate reductase beta subunit
LDO15_RS01770	COG2733	membrane
LDO15_RS01805	COG1064	alcohol dehydrogenase
LDO15_RS01825	COG4122	O-methyltransferase activity
LDO15_RS01850	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LDO15_RS01855	COG0574	Belongs to the PEP-utilizing enzyme family
LDO15_RS01855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LDO15_RS01860	COG2217	Heavy metal translocating P-type atpase
LDO15_RS01865	COG0726	polysaccharide deacetylase
LDO15_RS01885	COG1295	ribonuclease BN
LDO15_RS01910	COG0583	DNA-binding transcription factor activity
LDO15_RS01920	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS01930	COG1280	lysine exporter protein (LysE YggA)
LDO15_RS01945	COG1476	TRANSCRIPTIONal
LDO15_RS01965	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LDO15_RS01980	COG1396	sequence-specific DNA binding
LDO15_RS01980	COG1917	Cupin 2, conserved barrel domain protein
LDO15_RS01990	COG0010	Belongs to the arginase family
LDO15_RS01995	COG2252	PERMEase
LDO15_RS02015	COG3848	Pyruvate phosphate dikinase
LDO15_RS02015	COG0574	Belongs to the PEP-utilizing enzyme family
LDO15_RS02055	COG0697	spore germination
LDO15_RS02060	COG0583	DNA-binding transcription factor activity
LDO15_RS02075	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LDO15_RS02075	COG1796	DNA polymerase
LDO15_RS02155	COG1609	Transcriptional regulator
LDO15_RS02175	COG1024	Enoyl-CoA hydratase
LDO15_RS02195	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LDO15_RS02195	COG2124	cytochrome p450
LDO15_RS02200	COG1215	transferase activity, transferring glycosyl groups
LDO15_RS02225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDO15_RS02230	COG1960	acyl-CoA dehydrogenase activity
LDO15_RS02240	COG1012	belongs to the aldehyde dehydrogenase family
LDO15_RS02245	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LDO15_RS02255	COG0531	amino acid
LDO15_RS02260	COG2186	Transcriptional regulator
LDO15_RS02290	COG1278	Cold shock
LDO15_RS02300	COG3848	Pyruvate phosphate dikinase
LDO15_RS02300	COG0574	Belongs to the PEP-utilizing enzyme family
LDO15_RS02310	COG1063	alcohol dehydrogenase
LDO15_RS02315	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDO15_RS02320	COG2197	response regulator
LDO15_RS02335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LDO15_RS02345	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LDO15_RS02365	COG1609	Transcriptional regulator
LDO15_RS02390	COG0444	Belongs to the ABC transporter superfamily
LDO15_RS02405	COG0673	inositol 2-dehydrogenase activity
LDO15_RS02410	COG1609	Transcriptional regulator
LDO15_RS02415	COG1904	glucuronate isomerase
LDO15_RS02420	COG0246	Mannitol dehydrogenase
LDO15_RS02425	COG3250	beta-galactosidase activity
LDO15_RS02435	COG4948	Mandelate Racemase Muconate Lactonizing
LDO15_RS02460	COG1113	amino acid transport
LDO15_RS02470	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO15_RS02475	COG0022	dehydrogenase e1 component
LDO15_RS02475	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO15_RS02480	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LDO15_RS02485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDO15_RS02490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LDO15_RS02515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDO15_RS02515	COG0357	Ribosomal RNA small subunit methyltransferase G
LDO15_RS02525	COG0191	fructose-bisphosphate aldolase activity
LDO15_RS02545	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LDO15_RS02555	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LDO15_RS02575	COG1832	CoA-binding protein
LDO15_RS02590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDO15_RS02595	COG1832	CoA-binding protein
LDO15_RS02600	COG2315	Protein conserved in bacteria
LDO15_RS02605	COG4762	Protein conserved in bacteria
LDO15_RS02625	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LDO15_RS02630	COG0047	phosphoribosylformylglycinamidine synthase activity
LDO15_RS02665	COG1846	Transcriptional regulator
LDO15_RS02690	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LDO15_RS02725	COG0741	lytic transglycosylase activity
LDO15_RS02725	COG1196	nuclear chromosome segregation
LDO15_RS02725	COG0739	heme binding
LDO15_RS02730	COG0386	Belongs to the glutathione peroxidase family
LDO15_RS02735	COG1063	alcohol dehydrogenase
LDO15_RS02740	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LDO15_RS02745	COG0438	transferase activity, transferring glycosyl groups
LDO15_RS02795	COG0823	Involved in the tonB-independent uptake of proteins
LDO15_RS02810	COG0673	inositol 2-dehydrogenase activity
LDO15_RS02815	COG0673	inositol 2-dehydrogenase activity
LDO15_RS02825	COG0395	ABC-type sugar transport system, permease component
LDO15_RS02845	COG0673	inositol 2-dehydrogenase activity
LDO15_RS02850	COG1940	carbohydrate kinase activity
LDO15_RS02860	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LDO15_RS02880	COG0028	Belongs to the TPP enzyme family
LDO15_RS02885	COG0351	phosphomethylpyrimidine kinase
LDO15_RS02890	COG0477	Major facilitator Superfamily
LDO15_RS02940	COG0673	inositol 2-dehydrogenase activity
LDO15_RS02965	COG0343	queuine tRNA-ribosyltransferase activity
LDO15_RS02995	COG0671	phosphoesterase, PA-phosphatase related
LDO15_RS03005	COG3842	ATPase activity
LDO15_RS03045	COG1309	transcriptional regulator
LDO15_RS03050	COG0667	Aldo Keto reductase
LDO15_RS03060	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LDO15_RS03065	COG1120	ATPase activity
LDO15_RS03070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDO15_RS03075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LDO15_RS03085	COG0298	carbon dioxide binding
LDO15_RS03110	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LDO15_RS03135	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LDO15_RS03145	COG0586	Pfam SNARE associated Golgi protein
LDO15_RS03150	COG0564	pseudouridine synthase activity
LDO15_RS03170	COG2364	Membrane
LDO15_RS03175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LDO15_RS03180	COG1201	RNA secondary structure unwinding
LDO15_RS03215	COG1609	Transcriptional regulator
LDO15_RS03220	COG3250	beta-galactosidase activity
LDO15_RS03225	COG0395	ABC-type sugar transport system, permease component
LDO15_RS03240	COG2814	Major facilitator Superfamily
LDO15_RS03250	COG1129	ABC transporter
LDO15_RS03255	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDO15_RS03265	COG1879	ABC-type sugar transport system periplasmic component
LDO15_RS03270	COG3254	rhamnose metabolic process
LDO15_RS03275	COG4952	isomerase
LDO15_RS03280	COG3347	Dehydrogenase
LDO15_RS03280	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS03285	COG1070	Carbohydrate kinase
LDO15_RS03290	COG0247	lactate metabolic process
LDO15_RS03295	COG1139	Iron-sulfur cluster binding protein
LDO15_RS03300	COG1556	Lactate utilization protein
LDO15_RS03345	COG0438	transferase activity, transferring glycosyl groups
LDO15_RS03360	COG0671	phosphoesterase, PA-phosphatase related
LDO15_RS03365	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LDO15_RS03380	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LDO15_RS03385	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LDO15_RS03385	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LDO15_RS03400	COG2205	protein histidine kinase activity
LDO15_RS03405	COG0745	RESPONSE REGULATOR receiver
LDO15_RS03440	COG1309	transcriptional regulator
LDO15_RS03445	COG1511	domain protein
LDO15_RS03470	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LDO15_RS03480	COG1017	nitric oxide dioxygenase activity
LDO15_RS03480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDO15_RS03485	COG1959	2 iron, 2 sulfur cluster binding
LDO15_RS03495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LDO15_RS03500	COG0514	ATP-dependent DNA helicase (RecQ)
LDO15_RS03505	COG0477	Major facilitator Superfamily
LDO15_RS03520	COG1505	serine-type exopeptidase activity
LDO15_RS03555	COG0604	alcohol dehydrogenase
LDO15_RS03565	COG1966	Carbon starvation protein
LDO15_RS03585	COG0656	L-ascorbic acid biosynthetic process
LDO15_RS03625	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LDO15_RS03630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LDO15_RS03650	COG0588	phosphoglycerate mutase activity
LDO15_RS03660	COG5002	protein histidine kinase activity
LDO15_RS03680	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LDO15_RS03685	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LDO15_RS03695	COG0215	cysteine-tRNA ligase activity
LDO15_RS03700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDO15_RS03725	COG0366	Alpha amylase catalytic
LDO15_RS03735	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LDO15_RS03765	COG1609	Transcriptional regulator
LDO15_RS03770	COG0366	Alpha amylase catalytic
LDO15_RS03785	COG3833	ABC-type maltose transport systems, permease component
LDO15_RS03790	COG0366	Alpha amylase catalytic
LDO15_RS03795	COG0277	FAD linked oxidase domain protein
LDO15_RS03805	COG3842	ATPase activity
LDO15_RS03820	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LDO15_RS03850	COG2508	Transcriptional regulator
LDO15_RS03860	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LDO15_RS03865	COG1012	belongs to the aldehyde dehydrogenase family
LDO15_RS03910	COG2957	Belongs to the agmatine deiminase family
LDO15_RS03915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LDO15_RS03935	COG2124	cytochrome p450
LDO15_RS03940	COG0783	Belongs to the Dps family
LDO15_RS03945	COG0477	Major facilitator Superfamily
LDO15_RS03955	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LDO15_RS03955	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LDO15_RS03960	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LDO15_RS03965	COG0509	glycine decarboxylation via glycine cleavage system
LDO15_RS03970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LDO15_RS03980	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
LDO15_RS04000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LDO15_RS04015	COG1278	Cold shock
LDO15_RS04025	COG0459	protein refolding
LDO15_RS04030	COG0328	RNA-DNA hybrid ribonuclease activity
LDO15_RS04040	COG2205	protein histidine kinase activity
LDO15_RS04045	COG0745	RESPONSE REGULATOR receiver
LDO15_RS04065	COG1278	Cold shock
LDO15_RS04075	COG2814	Major facilitator Superfamily
LDO15_RS04090	COG0739	heme binding
LDO15_RS04120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LDO15_RS04150	COG0488	(ABC) transporter
LDO15_RS04155	COG1132	(ABC) transporter
LDO15_RS04160	COG0494	nUDIX hydrolase
LDO15_RS04205	COG0483	inositol monophosphate 1-phosphatase activity
LDO15_RS04220	COG0045	succinate-CoA ligase (ADP-forming) activity
LDO15_RS04235	COG0640	Transcriptional regulator
LDO15_RS04240	COG1942	4-Oxalocrotonate Tautomerase
LDO15_RS04245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDO15_RS04255	COG3962	Belongs to the TPP enzyme family
LDO15_RS04270	COG0673	inositol 2-dehydrogenase activity
LDO15_RS04275	COG1082	Xylose isomerase domain protein TIM barrel
LDO15_RS04280	COG2814	Major facilitator Superfamily
LDO15_RS04285	COG1846	Transcriptional regulator
LDO15_RS04290	COG2814	Major facilitator Superfamily
LDO15_RS04295	COG3718	enzyme involved in inositol metabolism
LDO15_RS04300	COG2188	Transcriptional regulator
LDO15_RS04310	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDO15_RS04320	COG0673	inositol 2-dehydrogenase activity
LDO15_RS04325	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LDO15_RS04335	COG2188	Transcriptional regulator
LDO15_RS04345	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS04375	COG1396	sequence-specific DNA binding
LDO15_RS04400	COG0028	Belongs to the TPP enzyme family
LDO15_RS04435	COG1401	restriction endodeoxyribonuclease activity
LDO15_RS04475	COG2072	flavoprotein involved in K transport
LDO15_RS04480	COG1063	alcohol dehydrogenase
LDO15_RS04485	COG1902	pentaerythritol trinitrate reductase activity
LDO15_RS04500	COG2376	Dihydroxyacetone kinase
LDO15_RS04505	COG0698	ribose 5-phosphate isomerase
LDO15_RS04510	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDO15_RS04515	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS04520	COG2271	Major facilitator Superfamily
LDO15_RS04525	COG0149	triose-phosphate isomerase activity
LDO15_RS04540	COG2183	response to ionizing radiation
LDO15_RS04550	COG0405	Gamma-glutamyltransferase
LDO15_RS04560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LDO15_RS04565	COG1695	Transcriptional regulator
LDO15_RS04590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDO15_RS04605	COG1652	LysM domain
LDO15_RS04615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LDO15_RS04620	COG0667	Aldo Keto reductase
LDO15_RS04635	COG0366	Alpha amylase catalytic
LDO15_RS04635	COG3103	Sh3 type 3 domain protein
LDO15_RS04645	COG0366	Alpha amylase catalytic
LDO15_RS04675	COG1254	Belongs to the acylphosphatase family
LDO15_RS04695	COG0477	Major facilitator Superfamily
LDO15_RS04700	COG0384	phenazine biosynthesis protein PhzF
LDO15_RS04705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LDO15_RS04745	COG1349	DNA-binding transcription factor activity
LDO15_RS04750	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS04765	COG0667	Aldo Keto reductase
LDO15_RS04770	COG4608	Belongs to the ABC transporter superfamily
LDO15_RS04780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO15_RS04785	COG0601	transmembrane transport
LDO15_RS04795	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LDO15_RS04800	COG2072	flavoprotein involved in K transport
LDO15_RS04860	COG1595	DNA-templated transcription, initiation
LDO15_RS04910	COG2801	Transposase and inactivated derivatives
LDO15_RS04950	COG0071	Belongs to the small heat shock protein (HSP20) family
LDO15_RS04975	COG3547	Transposase (IS116 IS110 IS902 family)
LDO15_RS04985	COG0028	Belongs to the TPP enzyme family
LDO15_RS04995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LDO15_RS05000	COG1113	amino acid transport
LDO15_RS05015	COG0366	Alpha amylase catalytic
LDO15_RS05035	COG1609	Transcriptional regulator
LDO15_RS05075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LDO15_RS05165	COG2072	flavoprotein involved in K transport
LDO15_RS05170	COG0456	acetyltransferase
LDO15_RS05175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDO15_RS05180	COG0477	Major facilitator Superfamily
LDO15_RS05190	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LDO15_RS05220	COG2186	Transcriptional regulator
LDO15_RS05250	COG1278	Cold shock
LDO15_RS05335	COG3665	Urea carboxylase-associated protein
LDO15_RS05380	COG5001	Diguanylate cyclase
LDO15_RS05385	COG3300	MHYT domain
LDO15_RS05385	COG5001	Diguanylate cyclase
LDO15_RS05390	COG0438	transferase activity, transferring glycosyl groups
LDO15_RS05400	COG2268	Band 7 protein
LDO15_RS05460	COG1012	belongs to the aldehyde dehydrogenase family
LDO15_RS05475	COG1024	Enoyl-CoA hydratase
LDO15_RS05490	COG1396	sequence-specific DNA binding
LDO15_RS05495	COG0477	Major facilitator Superfamily
LDO15_RS05535	COG0477	Major facilitator Superfamily
LDO15_RS05540	COG0138	bifunctional purine biosynthesis protein purh
LDO15_RS05550	COG2838	Isocitrate dehydrogenase
LDO15_RS05565	COG0515	serine threonine protein kinase
LDO15_RS05565	COG2815	serine threonine protein kinase
LDO15_RS05570	COG0673	inositol 2-dehydrogenase activity
LDO15_RS05590	COG4213	ABC transporter substrate-binding protein
LDO15_RS05595	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDO15_RS05620	COG0531	amino acid
LDO15_RS05645	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LDO15_RS05650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LDO15_RS05655	COG1131	(ABC) transporter
LDO15_RS05680	COG0180	Tryptophanyl-tRNA synthetase
LDO15_RS05700	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LDO15_RS05715	COG2009	succinate dehydrogenase
LDO15_RS05725	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LDO15_RS05725	COG1473	amidohydrolase
LDO15_RS05730	COG1846	Transcriptional regulator
LDO15_RS05735	COG1764	response to oxidative stress
LDO15_RS05740	COG2130	NADP-dependent
LDO15_RS05745	COG1744	ABC transporter substrate-binding protein PnrA-like
LDO15_RS05750	COG3845	ABC transporter
LDO15_RS05755	COG4603	Belongs to the binding-protein-dependent transport system permease family
LDO15_RS05760	COG1079	Belongs to the binding-protein-dependent transport system permease family
LDO15_RS05780	COG0586	Pfam SNARE associated Golgi protein
LDO15_RS05785	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LDO15_RS05790	COG3956	TIGRFAM MazG family protein
LDO15_RS05795	COG0148	phosphopyruvate hydratase activity
LDO15_RS05820	COG1252	NADH dehydrogenase
LDO15_RS05875	COG0183	Belongs to the thiolase family
LDO15_RS05880	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LDO15_RS05885	COG2017	converts alpha-aldose to the beta-anomer
LDO15_RS05895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LDO15_RS05905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LDO15_RS05915	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LDO15_RS05925	COG1331	Highly conserved protein containing a thioredoxin domain
LDO15_RS05930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDO15_RS05940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LDO15_RS05945	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LDO15_RS05990	COG0114	fumarate hydratase activity
LDO15_RS05995	COG0288	reversible hydration of carbon dioxide
LDO15_RS06005	COG1494	fructose-1,6-bisphosphatase
LDO15_RS06020	COG1482	cell wall glycoprotein biosynthetic process
LDO15_RS06025	COG1316	TRANSCRIPTIONal
LDO15_RS06030	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LDO15_RS06080	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LDO15_RS06085	COG1376	ErfK ybiS ycfS ynhG family protein
LDO15_RS06125	COG0714	Associated with various cellular activities
LDO15_RS06130	COG0084	hydrolase, TatD family'
LDO15_RS06135	COG3583	domain protein
LDO15_RS06140	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LDO15_RS06145	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LDO15_RS06150	COG0488	(ABC) transporter
LDO15_RS06165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LDO15_RS06175	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LDO15_RS06180	COG0193	aminoacyl-tRNA hydrolase activity
LDO15_RS06185	COG4566	intracellular signal transduction
LDO15_RS06190	COG2197	response regulator
LDO15_RS06215	COG0822	iron-sulfur transferase activity
LDO15_RS06220	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LDO15_RS06235	COG0702	epimerase
LDO15_RS06245	COG1988	membrane-bound metal-dependent
LDO15_RS06255	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LDO15_RS06260	COG0446	pyridine nucleotide-disulphide oxidoreductase
LDO15_RS06275	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LDO15_RS06285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LDO15_RS06290	COG1959	2 iron, 2 sulfur cluster binding
LDO15_RS06320	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
LDO15_RS06350	COG0243	molybdopterin cofactor binding
LDO15_RS06355	COG2223	nitrite transmembrane transporter activity
LDO15_RS06360	COG0477	Major facilitator Superfamily
LDO15_RS06370	COG4770	biotin carboxylase activity
LDO15_RS06375	COG0424	maF-like protein
LDO15_RS06385	COG2409	Drug exporters of the RND superfamily
LDO15_RS06400	COG1823	symporter activity
LDO15_RS06415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LDO15_RS06420	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS06425	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LDO15_RS06425	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LDO15_RS06445	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LDO15_RS06450	COG0483	inositol monophosphate 1-phosphatase activity
LDO15_RS06460	COG0251	oxidation-reduction process
LDO15_RS06470	COG4565	transcriptional regulatory protein
LDO15_RS06480	COG2851	Citrate transporter
LDO15_RS06485	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LDO15_RS06490	COG0154	amidase activity
LDO15_RS06495	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LDO15_RS06505	COG1063	alcohol dehydrogenase
LDO15_RS06510	COG0156	8-amino-7-oxononanoate synthase activity
LDO15_RS06520	COG1228	amidohydrolase
LDO15_RS06545	COG2873	o-acetylhomoserine
LDO15_RS06550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LDO15_RS06585	COG0400	carboxylic ester hydrolase activity
LDO15_RS06600	COG0423	glycine-tRNA ligase activity
LDO15_RS06645	COG0358	DNA primase activity
LDO15_RS06665	COG2814	Major facilitator Superfamily
LDO15_RS06675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LDO15_RS06705	COG0052	Belongs to the universal ribosomal protein uS2 family
LDO15_RS06710	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LDO15_RS06715	COG0528	UMP kinase activity
LDO15_RS06720	COG0233	cytoplasmic translational termination
LDO15_RS06725	COG0575	Belongs to the CDS family
LDO15_RS06735	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LDO15_RS06750	COG3275	phosphorelay sensor kinase activity
LDO15_RS06760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LDO15_RS06780	COG0022	dehydrogenase e1 component
LDO15_RS06785	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO15_RS06795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LDO15_RS06805	COG1960	acyl-CoA dehydrogenase activity
LDO15_RS06830	COG4565	transcriptional regulatory protein
LDO15_RS06835	COG3290	protein histidine kinase activity
LDO15_RS06860	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LDO15_RS06865	COG0750	zinc metalloprotease
LDO15_RS06945	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LDO15_RS06960	COG0442	prolyl-tRNA aminoacylation
LDO15_RS06975	COG3383	formate dehydrogenase (NAD+) activity
LDO15_RS06985	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
LDO15_RS07000	COG0779	Required for maturation of 30S ribosomal subunits
LDO15_RS07015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LDO15_RS07020	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LDO15_RS07025	COG3118	belongs to the thioredoxin family
LDO15_RS07040	COG0436	Aminotransferase
LDO15_RS07045	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LDO15_RS07080	COG3483	tryptophan 2,3-dioxygenase activity
LDO15_RS07090	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LDO15_RS07095	COG1185	polyribonucleotide nucleotidyltransferase activity
LDO15_RS07100	COG0612	Peptidase, M16
LDO15_RS07130	COG0745	RESPONSE REGULATOR receiver
LDO15_RS07135	COG5002	protein histidine kinase activity
LDO15_RS07155	COG0521	Mo-molybdopterin cofactor biosynthetic process
LDO15_RS07165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LDO15_RS07190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDO15_RS07195	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LDO15_RS07200	COG1674	ftsk spoiiie
LDO15_RS07210	COG1058	Belongs to the CinA family
LDO15_RS07210	COG1546	Belongs to the CinA family
LDO15_RS07215	COG1396	sequence-specific DNA binding
LDO15_RS07230	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LDO15_RS07235	COG2137	regulation of response to DNA damage stimulus
LDO15_RS07240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LDO15_RS07245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LDO15_RS07250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LDO15_RS07255	COG2813	Specifically methylates the guanine in position
LDO15_RS07260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LDO15_RS07270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LDO15_RS07280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LDO15_RS07285	COG0131	Imidazoleglycerol-phosphate dehydratase
LDO15_RS07290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LDO15_RS07300	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LDO15_RS07320	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LDO15_RS07325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LDO15_RS07330	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LDO15_RS07335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDO15_RS07340	COG2261	transglycosylase associated protein
LDO15_RS07350	COG2814	Major facilitator Superfamily
LDO15_RS07410	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LDO15_RS07415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDO15_RS07415	COG0072	phenylalanine-tRNA ligase activity
LDO15_RS07445	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LDO15_RS07450	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LDO15_RS07455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LDO15_RS07460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LDO15_RS07465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LDO15_RS07470	COG1438	arginine binding
LDO15_RS07475	COG0137	argininosuccinate synthase activity
LDO15_RS07480	COG0165	Argininosuccinate lyase
LDO15_RS07485	COG0259	pyridoxamine-phosphate oxidase activity
LDO15_RS07495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LDO15_RS07495	COG2169	Transcriptional regulator
LDO15_RS07505	COG2094	Belongs to the DNA glycosylase MPG family
LDO15_RS07520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LDO15_RS07530	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LDO15_RS07590	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LDO15_RS07595	COG0497	DNA recombination
LDO15_RS07600	COG0504	CTP synthase activity
LDO15_RS07605	COG0494	nUDIX hydrolase
LDO15_RS07625	COG1595	DNA-templated transcription, initiation
LDO15_RS07640	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LDO15_RS07645	COG2079	MmgE PrpD family protein
LDO15_RS07665	COG3290	protein histidine kinase activity
LDO15_RS07670	COG1301	dicarboxylic acid transport
LDO15_RS07680	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LDO15_RS07685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LDO15_RS07700	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LDO15_RS07710	COG1160	GTP binding
LDO15_RS07725	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LDO15_RS07730	COG0509	glycine decarboxylation via glycine cleavage system
LDO15_RS07755	COG1192	Involved in chromosome partitioning
LDO15_RS07760	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LDO15_RS07770	COG1940	carbohydrate kinase activity
LDO15_RS07795	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LDO15_RS07805	COG2815	serine threonine protein kinase
LDO15_RS07805	COG0515	serine threonine protein kinase
LDO15_RS07810	COG1388	LysM domain
LDO15_RS07810	COG1705	Flagellar rod assembly protein muramidase FlgJ
LDO15_RS07820	COG0142	geranyltranstransferase activity
LDO15_RS07830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LDO15_RS07840	COG2001	Belongs to the MraZ family
LDO15_RS07845	COG0275	rRNA processing
LDO15_RS07855	COG0768	penicillin binding
LDO15_RS07860	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LDO15_RS07870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LDO15_RS07875	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LDO15_RS07885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LDO15_RS07890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LDO15_RS07900	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LDO15_RS07905	COG1496	oxidoreductase activity
LDO15_RS07915	COG1799	cell septum assembly
LDO15_RS07925	COG3599	regulation of cell shape
LDO15_RS07930	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LDO15_RS07940	COG0587	DNA-directed DNA polymerase activity
LDO15_RS07955	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LDO15_RS07960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LDO15_RS07995	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LDO15_RS08000	COG0174	glutamine synthetase
LDO15_RS08005	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LDO15_RS08045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LDO15_RS08050	COG0321	lipoyl(octanoyl) transferase activity
LDO15_RS08070	COG4946	Tricorn protease homolog
LDO15_RS08070	COG0793	Belongs to the peptidase S41A family
LDO15_RS08075	COG1764	response to oxidative stress
LDO15_RS08090	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO15_RS08095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDO15_RS08100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LDO15_RS08120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LDO15_RS08130	COG0187	DNA topoisomerase II activity
LDO15_RS08150	COG1271	oxidase subunit
LDO15_RS08155	COG1294	oxidase, subunit
LDO15_RS08160	COG4988	ABC transporter
LDO15_RS08185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LDO15_RS08190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LDO15_RS08190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LDO15_RS08220	COG0756	dUTP diphosphatase activity
LDO15_RS08245	COG0569	domain protein
LDO15_RS08250	COG0531	amino acid
LDO15_RS08255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LDO15_RS08260	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LDO15_RS08265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LDO15_RS08280	COG0667	Aldo Keto reductase
LDO15_RS08300	COG1122	ATPase activity
LDO15_RS08310	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDO15_RS08310	COG1024	Enoyl-CoA hydratase
LDO15_RS08315	COG0183	Belongs to the thiolase family
LDO15_RS08320	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LDO15_RS08345	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LDO15_RS08360	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LDO15_RS08420	COG0242	peptide deformylase activity
LDO15_RS08425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LDO15_RS08435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LDO15_RS08455	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LDO15_RS08455	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LDO15_RS08460	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LDO15_RS08460	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LDO15_RS08465	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LDO15_RS08470	COG0140	phosphoribosyl-ATP diphosphatase activity
LDO15_RS08475	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LDO15_RS08480	COG0107	imidazoleglycerol-phosphate synthase activity
LDO15_RS08490	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LDO15_RS08510	COG0134	indole-3-glycerol-phosphate synthase activity
LDO15_RS08515	COG0133	tryptophan synthase activity
LDO15_RS08520	COG0159	tryptophan synthase activity
LDO15_RS08525	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LDO15_RS08530	COG0069	glutamate synthase activity
LDO15_RS08530	COG0067	glutamate synthase
LDO15_RS08530	COG0070	glutamate synthase
LDO15_RS08540	COG0469	pyruvate kinase activity
LDO15_RS08575	COG0210	DNA helicase
LDO15_RS08625	COG5290	Psort location Cytoplasmic, score
LDO15_RS08675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LDO15_RS08725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO15_RS08730	COG2814	Major facilitator Superfamily
LDO15_RS08740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO15_RS08755	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LDO15_RS08790	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDO15_RS08795	COG1129	ABC transporter
LDO15_RS08815	COG2801	Transposase and inactivated derivatives
LDO15_RS08815	COG3415	Transposase
LDO15_RS08825	COG3387	PFAM Glycoside hydrolase 15-related
LDO15_RS08860	COG1414	Transcriptional regulator
LDO15_RS08890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO15_RS08905	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS08910	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS08915	COG2085	NADP oxidoreductase coenzyme F420-dependent
LDO15_RS08920	COG0183	Belongs to the thiolase family
LDO15_RS08925	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LDO15_RS08930	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS08985	COG2072	flavoprotein involved in K transport
LDO15_RS08990	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS09005	COG0640	Transcriptional regulator
LDO15_RS09020	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LDO15_RS09030	COG0028	Belongs to the TPP enzyme family
LDO15_RS09035	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO15_RS09045	COG1802	Transcriptional regulator
LDO15_RS09055	COG2814	Major facilitator Superfamily
LDO15_RS09075	COG0477	Major facilitator Superfamily
LDO15_RS09090	COG1621	beta-fructofuranosidase activity
LDO15_RS09095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDO15_RS09100	COG1609	Transcriptional regulator
LDO15_RS09110	COG0395	ABC-type sugar transport system, permease component
LDO15_RS09150	COG1012	belongs to the aldehyde dehydrogenase family
LDO15_RS09160	COG0833	amino acid
LDO15_RS09175	COG1414	Transcriptional regulator
LDO15_RS09190	COG2040	homocysteine
LDO15_RS09200	COG1396	sequence-specific DNA binding
LDO15_RS09210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LDO15_RS09215	COG0531	amino acid
LDO15_RS09245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LDO15_RS09250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDO15_RS09260	COG0589	response to stress
LDO15_RS09300	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LDO15_RS09355	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LDO15_RS09365	COG2267	carboxylic ester hydrolase activity
LDO15_RS09395	COG2801	Transposase and inactivated derivatives
LDO15_RS09410	COG3654	unkown
LDO15_RS09435	COG0667	Aldo Keto reductase
LDO15_RS09460	COG2159	amidohydrolase
LDO15_RS09465	COG0583	DNA-binding transcription factor activity
LDO15_RS09495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDO15_RS09500	COG1012	belongs to the aldehyde dehydrogenase family
LDO15_RS09505	COG0028	Belongs to the TPP enzyme family
LDO15_RS09520	COG0477	Major facilitator Superfamily
LDO15_RS09525	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LDO15_RS09550	COG1473	amidohydrolase
LDO15_RS09555	COG0477	Major facilitator Superfamily
LDO15_RS09565	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LDO15_RS09575	COG0667	Aldo Keto reductase
LDO15_RS09595	COG0395	ABC-type sugar transport system, permease component
LDO15_RS09615	COG1609	Transcriptional regulator
LDO15_RS09620	COG1309	transcriptional regulator
LDO15_RS09625	COG1902	pentaerythritol trinitrate reductase activity
LDO15_RS09640	COG0604	alcohol dehydrogenase
LDO15_RS09640	COG3321	synthase
LDO15_RS09730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LDO15_RS09740	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LDO15_RS09750	COG0531	amino acid
LDO15_RS09960	COG0586	Pfam SNARE associated Golgi protein
LDO15_RS09975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDO15_RS10000	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LDO15_RS10005	COG3285	dna ligase
LDO15_RS10005	COG1793	dna ligase
LDO15_RS10020	COG0667	Aldo Keto reductase
LDO15_RS10060	COG2814	Major facilitator Superfamily
LDO15_RS10085	COG2814	Major facilitator Superfamily
LDO15_RS10095	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LDO15_RS10165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LDO15_RS10205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDO15_RS10215	COG1960	acyl-CoA dehydrogenase activity
LDO15_RS10225	COG0702	epimerase
LDO15_RS10240	COG0492	ferredoxin-NADP+ reductase activity
LDO15_RS10245	COG2015	COG2015, Alkyl sulfatase and related hydrolases
LDO15_RS10250	COG1280	lysine exporter protein (LysE YggA)
LDO15_RS10255	COG0477	Major facilitator Superfamily
LDO15_RS10265	COG0628	permease
LDO15_RS10295	COG2909	trisaccharide binding
LDO15_RS10295	COG2909	trisaccharide binding
LDO15_RS10300	COG0589	response to stress
LDO15_RS10310	COG1414	Transcriptional regulator
LDO15_RS10320	COG0747	negative chemotaxis
LDO15_RS10340	COG3250	beta-galactosidase activity
LDO15_RS10350	COG3250	beta-galactosidase activity
LDO15_RS10360	COG0657	acetylesterase activity
LDO15_RS10365	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDO15_RS10370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDO15_RS10415	COG1643	Atp-dependent helicase
LDO15_RS10420	COG1819	glycosyl
LDO15_RS10455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LDO15_RS10460	COG0730	response to heat
LDO15_RS10470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LDO15_RS10500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDO15_RS10500	COG0723	plastoquinol--plastocyanin reductase activity
LDO15_RS10540	COG0745	RESPONSE REGULATOR receiver
LDO15_RS10545	COG2205	protein histidine kinase activity
LDO15_RS10560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LDO15_RS10575	COG0009	L-threonylcarbamoyladenylate synthase
LDO15_RS10595	COG2197	response regulator
LDO15_RS10605	COG1222	aaa ATPase
LDO15_RS10685	COG2909	trisaccharide binding
LDO15_RS10690	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS10695	COG2249	NAD(P)H dehydrogenase (quinone) activity
LDO15_RS10705	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LDO15_RS10705	COG3608	succinylglutamate desuccinylase aspartoacylase
LDO15_RS10720	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LDO15_RS10730	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LDO15_RS10730	COG3608	succinylglutamate desuccinylase aspartoacylase
LDO15_RS10780	COG2132	Multicopper oxidase
LDO15_RS10790	COG0318	PFAM AMP-dependent synthetase and ligase
LDO15_RS10795	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LDO15_RS10805	COG0589	response to stress
LDO15_RS10825	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LDO15_RS10830	COG2050	protein possibly involved in aromatic compounds catabolism
LDO15_RS10840	COG4552	Acetyltransferase involved in intracellular survival and related
LDO15_RS10845	COG0539	negative regulation of cytoplasmic translation
LDO15_RS10860	COG1739	Uncharacterized protein family UPF0029
LDO15_RS10865	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LDO15_RS10865	COG0237	dephospho-CoA kinase activity
LDO15_RS10870	COG0556	nucleotide-excision repair
LDO15_RS10900	COG4106	trans-aconitate 2-methyltransferase activity
LDO15_RS10925	COG0546	phosphoglycolate phosphatase activity
LDO15_RS10935	COG0322	excinuclease ABC activity
LDO15_RS10940	COG1660	Displays ATPase and GTPase activities
LDO15_RS10945	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LDO15_RS10950	COG1481	regulation of sporulation
LDO15_RS10955	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LDO15_RS10965	COG0126	phosphoglycerate kinase activity
LDO15_RS10970	COG0149	triose-phosphate isomerase activity
LDO15_RS10975	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LDO15_RS10985	COG0363	glucosamine-6-phosphate deaminase activity
LDO15_RS11000	COG0166	Belongs to the GPI family
LDO15_RS11005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LDO15_RS11015	COG0109	protoheme IX farnesyltransferase activity
LDO15_RS11020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LDO15_RS11025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LDO15_RS11025	COG2755	lipolytic protein G-D-S-L family
LDO15_RS11035	COG1612	heme a metabolic process
LDO15_RS11045	COG1131	(ABC) transporter
LDO15_RS11070	COG0396	ATPase activity
LDO15_RS11075	COG2151	metal-sulfur cluster biosynthetic enzyme
LDO15_RS11090	COG0318	PFAM AMP-dependent synthetase and ligase
LDO15_RS11105	COG1122	ATPase activity
LDO15_RS11110	COG1268	BioY protein
LDO15_RS11115	COG0488	(ABC) transporter
LDO15_RS11140	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS11155	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS11160	COG0560	Phosphoserine phosphatase
LDO15_RS11160	COG3830	Belongs to the UPF0237 family
LDO15_RS11165	COG1119	ATPase activity
LDO15_RS11180	COG0254	rRNA binding
LDO15_RS11195	COG2855	membrane
LDO15_RS11200	COG2308	Evidence 4 Homologs of previously reported genes of
LDO15_RS11245	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LDO15_RS11250	COG0297	glycogen (starch) synthase activity
LDO15_RS11270	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS11295	COG0435	Glutathione S-transferase
LDO15_RS11320	COG3511	phospholipase C
LDO15_RS11370	COG0667	Aldo Keto reductase
LDO15_RS11375	COG1968	undecaprenyl-diphosphatase activity
LDO15_RS11380	COG0215	cysteine-tRNA ligase activity
LDO15_RS11390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDO15_RS11405	COG1222	aaa ATPase
LDO15_RS11410	COG4122	O-methyltransferase activity
LDO15_RS11420	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LDO15_RS11425	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LDO15_RS11430	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LDO15_RS11455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LDO15_RS11460	COG0805	protein transport
LDO15_RS11465	COG4581	dead DEAH box helicase
LDO15_RS11470	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LDO15_RS11475	COG1216	Glycosyl transferase, family 2
LDO15_RS11500	COG4946	Tricorn protease homolog
LDO15_RS11500	COG1506	peptidase
LDO15_RS11500	COG0823	Involved in the tonB-independent uptake of proteins
LDO15_RS11505	COG0242	peptide deformylase activity
LDO15_RS11520	COG2264	protein methyltransferase activity
LDO15_RS11525	COG3424	synthase
LDO15_RS11560	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDO15_RS11575	COG2814	Major facilitator Superfamily
LDO15_RS11580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDO15_RS11585	COG1609	Transcriptional regulator
LDO15_RS11595	COG1175	transmembrane transport
LDO15_RS11600	COG0395	ABC-type sugar transport system, permease component
LDO15_RS11605	COG1621	beta-fructofuranosidase activity
LDO15_RS11635	COG2261	transglycosylase associated protein
LDO15_RS11670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDO15_RS11695	COG1396	sequence-specific DNA binding
LDO15_RS11695	COG3800	Transcriptional regulator
LDO15_RS11705	COG0076	glutamate decarboxylase activity
LDO15_RS11745	COG0789	Transcriptional regulator
LDO15_RS11750	COG3177	Filamentation induced by cAMP protein fic
LDO15_RS11760	COG0477	Major facilitator Superfamily
LDO15_RS11790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LDO15_RS11795	COG1845	cytochrome c oxidase, subunit III
LDO15_RS11800	COG2010	Cytochrome c
LDO15_RS11805	COG0723	plastoquinol--plastocyanin reductase activity
LDO15_RS11810	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LDO15_RS11815	COG2188	Transcriptional regulator
LDO15_RS11820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDO15_RS11830	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LDO15_RS11835	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LDO15_RS11855	COG0167	dihydroorotate dehydrogenase activity
LDO15_RS11870	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LDO15_RS11875	COG1381	Involved in DNA repair and RecF pathway recombination
LDO15_RS11880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LDO15_RS11885	COG3590	peptidase
LDO15_RS11895	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS11900	COG1316	TRANSCRIPTIONal
LDO15_RS11905	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LDO15_RS11915	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LDO15_RS11955	COG0798	PFAM Bile acid sodium symporter
LDO15_RS11960	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDO15_RS11970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDO15_RS12000	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LDO15_RS12005	COG0484	heat shock protein binding
LDO15_RS12010	COG1420	regulation of RNA biosynthetic process
LDO15_RS12030	COG0481	GTPase activity
LDO15_RS12040	COG0268	Binds directly to 16S ribosomal RNA
LDO15_RS12060	COG1596	polysaccharide export
LDO15_RS12060	COG1555	photosystem II stabilization
LDO15_RS12075	COG1307	EDD domain protein, DegV family
LDO15_RS12080	COG0495	leucyl-tRNA aminoacylation
LDO15_RS12105	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LDO15_RS12110	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LDO15_RS12115	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LDO15_RS12125	COG0656	L-ascorbic acid biosynthetic process
LDO15_RS12150	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LDO15_RS12160	COG1758	RNA polymerase activity
LDO15_RS12165	COG0194	GDP metabolic process
LDO15_RS12170	COG0194	GDP metabolic process
LDO15_RS12175	COG0284	orotidine-5'-phosphate decarboxylase activity
LDO15_RS12180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LDO15_RS12185	COG0505	Belongs to the CarA family
LDO15_RS12195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LDO15_RS12200	COG0540	Belongs to the ATCase OTCase family
LDO15_RS12205	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LDO15_RS12215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LDO15_RS12220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LDO15_RS12230	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LDO15_RS12235	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LDO15_RS12240	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LDO15_RS12245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDO15_RS12255	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LDO15_RS12260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LDO15_RS12275	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LDO15_RS12315	COG1414	Transcriptional regulator
LDO15_RS12320	COG1053	succinate dehydrogenase
LDO15_RS12325	COG1414	Transcriptional regulator
LDO15_RS12335	COG1053	succinate dehydrogenase
LDO15_RS12345	COG0477	Major facilitator Superfamily
LDO15_RS12360	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LDO15_RS12370	COG0124	histidyl-tRNA synthetase
LDO15_RS12380	COG1196	nuclear chromosome segregation
LDO15_RS12390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LDO15_RS12395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LDO15_RS12400	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LDO15_RS12410	COG2255	four-way junction helicase activity
LDO15_RS12415	COG0632	four-way junction helicase activity
LDO15_RS12420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LDO15_RS12425	COG0217	transcriptional regulatory protein
LDO15_RS12430	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LDO15_RS12435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LDO15_RS12470	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LDO15_RS12475	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LDO15_RS12485	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LDO15_RS12490	COG0587	DNA-directed DNA polymerase activity
LDO15_RS12505	COG1605	Chorismate mutase
LDO15_RS12505	COG0077	Prephenate dehydratase
LDO15_RS12530	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LDO15_RS12535	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LDO15_RS12540	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LDO15_RS12560	COG2135	peptidase activity
LDO15_RS12595	COG2801	Transposase and inactivated derivatives
LDO15_RS12620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDO15_RS12670	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LDO15_RS12675	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LDO15_RS12685	COG0577	efflux transmembrane transporter activity
LDO15_RS12685	COG1136	(ABC) transporter
LDO15_RS12705	COG2822	iron ion transport
LDO15_RS12710	COG2837	iron assimilation
LDO15_RS12735	COG2186	Transcriptional regulator
LDO15_RS12745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO15_RS12855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LDO15_RS12860	COG0671	phosphoesterase, PA-phosphatase related
LDO15_RS12865	COG0586	Pfam SNARE associated Golgi protein
LDO15_RS12875	COG5002	protein histidine kinase activity
LDO15_RS12890	COG0475	glutathione-regulated potassium exporter activity
LDO15_RS12890	COG0569	domain protein
LDO15_RS12985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LDO15_RS12995	COG1053	succinate dehydrogenase
LDO15_RS13000	COG0656	L-ascorbic acid biosynthetic process
LDO15_RS13010	COG0446	pyridine nucleotide-disulphide oxidoreductase
LDO15_RS13010	COG1902	pentaerythritol trinitrate reductase activity
LDO15_RS13015	COG0673	inositol 2-dehydrogenase activity
LDO15_RS13020	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS13025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDO15_RS13035	COG0583	DNA-binding transcription factor activity
LDO15_RS13045	COG0596	Alpha beta hydrolase
LDO15_RS13060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDO15_RS13070	COG0765	amino acid transport
LDO15_RS13075	COG1126	abc transporter atp-binding protein
LDO15_RS13080	COG2423	ornithine cyclodeaminase activity
LDO15_RS13105	COG1012	belongs to the aldehyde dehydrogenase family
LDO15_RS13110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LDO15_RS13115	COG0247	lactate metabolic process
LDO15_RS13115	COG0277	FAD linked oxidase domain protein
LDO15_RS13125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LDO15_RS13140	COG1942	4-Oxalocrotonate Tautomerase
LDO15_RS13160	COG2070	2-Nitropropane dioxygenase
LDO15_RS13165	COG2814	Major facilitator Superfamily
LDO15_RS13185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDO15_RS13215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO15_RS13220	COG3511	phospholipase C
LDO15_RS13235	COG1335	isochorismatase
LDO15_RS13240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LDO15_RS13245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LDO15_RS13250	COG1780	Probably involved in ribonucleotide reductase function
LDO15_RS13260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LDO15_RS13265	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LDO15_RS13280	COG0583	DNA-binding transcription factor activity
LDO15_RS13290	COG1012	belongs to the aldehyde dehydrogenase family
LDO15_RS13320	COG2890	protein-(glutamine-N5) methyltransferase activity
LDO15_RS13325	COG0492	ferredoxin-NADP+ reductase activity
LDO15_RS13330	COG2824	Alkylphosphonate utilization operon protein PhnA
LDO15_RS13335	COG1126	abc transporter atp-binding protein
LDO15_RS13340	COG0765	amino acid transport
LDO15_RS13345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDO15_RS13360	COG0799	negative regulation of ribosome biogenesis
LDO15_RS13370	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LDO15_RS13380	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LDO15_RS13385	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LDO15_RS13390	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LDO15_RS13395	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LDO15_RS13400	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LDO15_RS13405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LDO15_RS13405	COG0352	thiamine-phosphate diphosphorylase activity
LDO15_RS13405	COG0351	phosphomethylpyrimidine kinase
LDO15_RS13410	COG1530	ribonuclease E activity
LDO15_RS13430	COG0285	dihydrofolate synthase activity
LDO15_RS13435	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LDO15_RS13465	COG3189	MarR family transcriptional regulator
LDO15_RS13470	COG0525	valine-tRNA ligase activity
LDO15_RS13480	COG3387	PFAM Glycoside hydrolase 15-related
LDO15_RS13485	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LDO15_RS13490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LDO15_RS13495	COG0740	serine-type endopeptidase activity
LDO15_RS13500	COG0740	serine-type endopeptidase activity
LDO15_RS13505	COG0544	peptidyl-prolyl cis-trans isomerase activity
LDO15_RS13525	COG0698	ribose 5-phosphate isomerase
LDO15_RS13550	COG0668	transmembrane transport
LDO15_RS13570	COG1946	Acyl-CoA thioesterase
LDO15_RS13585	COG0629	single-stranded DNA binding
LDO15_RS13600	COG0598	Magnesium transport protein CorA
LDO15_RS13605	COG5416	Lipopolysaccharide assembly protein A domain
LDO15_RS13655	COG2326	polyphosphate kinase activity
LDO15_RS13695	COG0330	HflC and HflK could
LDO15_RS13705	COG3022	response to hydroperoxide
LDO15_RS13715	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LDO15_RS13720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LDO15_RS13730	COG1045	serine acetyltransferase
LDO15_RS13735	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS13740	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LDO15_RS13750	COG1063	alcohol dehydrogenase
LDO15_RS13755	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS13765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDO15_RS13770	COG0477	Major facilitator Superfamily
LDO15_RS13820	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LDO15_RS13835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LDO15_RS13840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LDO15_RS13845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LDO15_RS13855	COG4974	Belongs to the 'phage' integrase family
LDO15_RS13870	COG0792	nuclease activity
LDO15_RS13875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LDO15_RS13885	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LDO15_RS13895	COG0681	Belongs to the peptidase S26 family
LDO15_RS13900	COG0335	large ribosomal subunit rRNA binding
LDO15_RS13905	COG0336	Belongs to the RNA methyltransferase TrmD family
LDO15_RS13910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LDO15_RS13915	COG1837	Belongs to the UPF0109 family
LDO15_RS13920	COG0228	four-way junction DNA binding
LDO15_RS13930	COG2514	catechol 2,3-dioxygenase activity
LDO15_RS13940	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LDO15_RS13955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LDO15_RS13970	COG2814	Major facilitator Superfamily
LDO15_RS14000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LDO15_RS14005	COG0318	PFAM AMP-dependent synthetase and ligase
LDO15_RS14010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDO15_RS14025	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LDO15_RS14030	COG0571	ribonuclease III activity
LDO15_RS14035	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LDO15_RS14045	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LDO15_RS14050	COG0300	oxidoreductase activity
LDO15_RS14065	COG0742	ribosomal rna small subunit methyltransferase
LDO15_RS14100	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LDO15_RS14120	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LDO15_RS14155	COG1215	transferase activity, transferring glycosyl groups
LDO15_RS14170	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LDO15_RS14180	COG1134	teichoic acid transport
LDO15_RS14190	COG0297	glycogen (starch) synthase activity
LDO15_RS14210	COG1181	Belongs to the D-alanine--D-alanine ligase family
LDO15_RS14215	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LDO15_RS14225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LDO15_RS14230	COG0066	3-isopropylmalate dehydratase activity
LDO15_RS14235	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LDO15_RS14240	COG1414	Transcriptional regulator
LDO15_RS14275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LDO15_RS14280	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDO15_RS14295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LDO15_RS14300	COG0473	3-isopropylmalate dehydrogenase activity
LDO15_RS14310	COG0577	efflux transmembrane transporter activity
LDO15_RS14310	COG1136	(ABC) transporter
LDO15_RS14320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDO15_RS14325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LDO15_RS14330	COG0440	acetolactate synthase activity
LDO15_RS14340	COG0129	dihydroxy-acid dehydratase activity
LDO15_RS14350	COG0088	Forms part of the polypeptide exit tunnel
LDO15_RS14500	COG0747	negative chemotaxis
LDO15_RS14505	COG0579	oxidoreductase
LDO15_RS14510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LDO15_RS14550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO15_RS14560	COG1305	Transglutaminase-like
LDO15_RS14570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDO15_RS14585	COG1104	cysteine desulfurase activity
LDO15_RS14595	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LDO15_RS14600	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LDO15_RS14620	COG1113	amino acid transport
LDO15_RS14630	COG0022	dehydrogenase e1 component
LDO15_RS14635	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO15_RS14645	COG0477	Major facilitator Superfamily
LDO15_RS14670	COG0419	ATPase involved in DNA repair
LDO15_RS14675	COG0420	3'-5' exonuclease activity
LDO15_RS14680	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LDO15_RS14690	COG2149	membrane
LDO15_RS14710	COG0586	Pfam SNARE associated Golgi protein
LDO15_RS14715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LDO15_RS14720	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LDO15_RS14725	COG1234	tRNA 3'-trailer cleavage
LDO15_RS14730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LDO15_RS14740	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LDO15_RS14750	COG1335	isochorismatase
LDO15_RS14770	COG0363	glucosamine-6-phosphate deaminase activity
LDO15_RS14785	COG1902	pentaerythritol trinitrate reductase activity
LDO15_RS14815	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
LDO15_RS14825	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LDO15_RS14830	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LDO15_RS14840	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LDO15_RS14845	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LDO15_RS14850	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LDO15_RS14855	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LDO15_RS14860	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LDO15_RS14865	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LDO15_RS14870	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LDO15_RS14875	COG0356	it plays a direct role in the translocation of protons across the membrane
LDO15_RS14910	COG2890	protein-(glutamine-N5) methyltransferase activity
LDO15_RS14915	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LDO15_RS14925	COG0083	homoserine kinase activity
LDO15_RS14930	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LDO15_RS14935	COG0460	homoserine dehydrogenase
LDO15_RS14940	COG0019	diaminopimelate decarboxylase activity
LDO15_RS14945	COG0018	arginyl-trna synthetase
LDO15_RS14990	COG4829	muconolactone delta-isomerase
LDO15_RS14995	COG3485	protocatechuate 3,4-dioxygenase
LDO15_RS15005	COG0583	DNA-binding transcription factor activity
LDO15_RS15010	COG4638	Rieske (2fe-2S)
LDO15_RS15015	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LDO15_RS15030	COG2814	Major facilitator Superfamily
LDO15_RS15040	COG1643	Atp-dependent helicase
LDO15_RS15045	COG0537	adenosine 5'-monophosphoramidase activity
LDO15_RS15050	COG1064	alcohol dehydrogenase
LDO15_RS15080	COG1121	(ABC) transporter
LDO15_RS15105	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO15_RS15105	COG0567	Dehydrogenase, E1 component
LDO15_RS15130	COG1595	DNA-templated transcription, initiation
LDO15_RS15140	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LDO15_RS15150	COG0483	inositol monophosphate 1-phosphatase activity
LDO15_RS15155	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LDO15_RS15175	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LDO15_RS15180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LDO15_RS15210	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LDO15_RS15225	COG2884	Cell division ATP-binding protein ftsE
LDO15_RS15230	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LDO15_RS15275	COG2246	polysaccharide biosynthetic process
LDO15_RS15295	COG1088	dTDP-glucose 4,6-dehydratase activity
LDO15_RS15320	COG0463	Glycosyl transferase, family 2
LDO15_RS15350	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LDO15_RS15385	COG1216	Glycosyl transferase, family 2
LDO15_RS15420	COG2902	Dehydrogenase
LDO15_RS15455	COG0653	protein targeting
LDO15_RS15460	COG3214	Protein conserved in bacteria
LDO15_RS15465	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LDO15_RS15470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LDO15_RS15475	COG5401	PFAM Sporulation and spore germination
LDO15_RS15480	COG5000	phosphorelay sensor kinase activity
LDO15_RS15480	COG5002	protein histidine kinase activity
LDO15_RS15515	COG0601	transmembrane transport
LDO15_RS15525	COG0482	sulfurtransferase activity
LDO15_RS15555	COG1597	lipid kinase activity
LDO15_RS15565	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LDO15_RS15570	COG1595	DNA-templated transcription, initiation
LDO15_RS15585	COG3265	gluconokinase activity
LDO15_RS15590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LDO15_RS15595	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LDO15_RS15600	COG2086	electron transfer activity
LDO15_RS15605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LDO15_RS15615	COG1842	Phage shock protein A
LDO15_RS15620	COG0415	Belongs to the DNA photolyase family
LDO15_RS15635	COG1615	UPF0182 protein
LDO15_RS15640	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LDO15_RS15660	COG2816	NAD+ diphosphatase activity
LDO15_RS15690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDO15_RS15695	COG0765	amino acid transport
LDO15_RS15700	COG1126	abc transporter atp-binding protein
LDO15_RS15705	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LDO15_RS15710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO15_RS15715	COG0113	porphobilinogen synthase activity
LDO15_RS15725	COG0181	hydroxymethylbilane synthase activity
LDO15_RS15730	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LDO15_RS15735	COG3253	May function as heme-dependent peroxidase
LDO15_RS15750	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LDO15_RS15755	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LDO15_RS15785	COG2022	thiamine diphosphate biosynthetic process
LDO15_RS15795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDO15_RS15795	COG2022	thiamine diphosphate biosynthetic process
LDO15_RS15800	COG0352	thiamine-phosphate diphosphorylase activity
LDO15_RS15815	COG0513	Belongs to the DEAD box helicase family
LDO15_RS15820	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LDO15_RS15825	COG0613	PHP domain protein
LDO15_RS15830	COG0006	proline dipeptidase activity
LDO15_RS15840	COG2239	Acts as a magnesium transporter
LDO15_RS15855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LDO15_RS15865	COG1595	DNA-templated transcription, initiation
LDO15_RS15895	COG1126	abc transporter atp-binding protein
LDO15_RS15900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDO15_RS15905	COG0765	amino acid transport
LDO15_RS15910	COG0765	amino acid transport
LDO15_RS15915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDO15_RS15920	COG2171	N-acyltransferase activity
LDO15_RS15935	COG3226	Transcriptional regulator
LDO15_RS15970	COG1217	gtp-binding protein TYPA
LDO15_RS15985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO15_RS15990	COG0601	transmembrane transport
LDO15_RS15995	COG4166	transmembrane transport
LDO15_RS16000	COG4172	Belongs to the ABC transporter superfamily
LDO15_RS16010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO15_RS16020	COG4166	transmembrane transport
LDO15_RS16025	COG0012	GTP binding
LDO15_RS16030	COG1322	Protein conserved in bacteria
LDO15_RS16035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LDO15_RS16045	COG1570	exodeoxyribonuclease VII activity
LDO15_RS16050	COG1722	exodeoxyribonuclease VII activity
LDO15_RS16055	COG2326	polyphosphate kinase activity
LDO15_RS16060	COG0436	Aminotransferase
LDO15_RS16070	COG1174	glycine betaine transport
LDO15_RS16075	COG1174	glycine betaine transport
LDO15_RS16085	COG1162	GTPase activity
LDO15_RS16095	COG2971	BadF BadG BcrA BcrD
LDO15_RS16100	COG0583	DNA-binding transcription factor activity
LDO15_RS16105	COG2814	Major facilitator Superfamily
LDO15_RS16110	COG0626	cystathionine gamma-synthase activity
LDO15_RS16130	COG0598	Magnesium transport protein CorA
LDO15_RS16145	COG0488	(ABC) transporter
LDO15_RS16180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LDO15_RS16185	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LDO15_RS16205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LDO15_RS16205	COG0519	Catalyzes the synthesis of GMP from XMP
LDO15_RS16225	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LDO15_RS16230	COG0516	GMP reductase activity
LDO15_RS16240	COG1132	(ABC) transporter
LDO15_RS16270	COG0459	protein refolding
LDO15_RS16275	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LDO15_RS16290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDO15_RS16295	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LDO15_RS16300	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LDO15_RS16315	COG0802	atpase or kinase
LDO15_RS16320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LDO15_RS16330	COG1486	melibiose metabolic process
LDO15_RS16340	COG0438	transferase activity, transferring glycosyl groups
LDO15_RS16345	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LDO15_RS16355	COG0667	Aldo Keto reductase
LDO15_RS16380	COG0736	holo-[acyl-carrier-protein] synthase activity
LDO15_RS16385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LDO15_RS16390	COG1072	(Pantothenic acid kinase))
LDO15_RS16400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LDO15_RS16410	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LDO15_RS16415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LDO15_RS16420	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LDO15_RS16455	COG2894	cell division
LDO15_RS16495	COG2894	cell division
LDO15_RS16520	COG0745	RESPONSE REGULATOR receiver
LDO15_RS16525	COG5002	protein histidine kinase activity
LDO15_RS16530	COG0101	tRNA pseudouridine synthase activity
LDO15_RS16535	COG0203	ribosomal protein L17
LDO15_RS16540	COG0202	RNA polymerase activity
LDO15_RS16545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LDO15_RS16550	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LDO15_RS16555	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LDO15_RS16560	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LDO15_RS16565	COG3191	aminopeptidase activity
LDO15_RS16570	COG1175	transmembrane transport
LDO15_RS16590	COG0563	adenylate kinase activity
LDO15_RS16600	COG0200	Binds to the 23S rRNA
LDO15_RS16605	COG1841	ribosomal large subunit assembly
LDO15_RS16610	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LDO15_RS16620	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LDO15_RS16625	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LDO15_RS16630	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LDO15_RS16635	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LDO15_RS16640	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LDO15_RS16645	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LDO15_RS16655	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LDO15_RS16660	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LDO15_RS16665	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LDO15_RS16670	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LDO15_RS16675	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LDO15_RS16680	COG0089	rRNA binding
LDO15_RS16685	COG0088	Forms part of the polypeptide exit tunnel
LDO15_RS16690	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LDO15_RS16695	COG0051	transcription antitermination factor activity, RNA binding
LDO15_RS16710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LDO15_RS16715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LDO15_RS16720	COG0049	tRNA binding
LDO15_RS16725	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LDO15_RS16730	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LDO15_RS16735	COG0085	RNA polymerase activity
LDO15_RS16740	COG0183	Belongs to the thiolase family
LDO15_RS16745	COG0442	prolyl-tRNA aminoacylation
LDO15_RS16750	COG0737	Belongs to the 5'-nucleotidase family
LDO15_RS16760	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LDO15_RS16785	COG2814	Major facilitator Superfamily
LDO15_RS16790	COG2814	Major facilitator Superfamily
LDO15_RS16795	COG0081	regulation of translation
LDO15_RS16800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LDO15_RS16810	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LDO15_RS16820	COG0436	Aminotransferase
LDO15_RS16825	COG2197	response regulator
LDO15_RS16875	COG0354	folic acid binding
LDO15_RS16885	COG3485	protocatechuate 3,4-dioxygenase
LDO15_RS16895	COG0745	RESPONSE REGULATOR receiver
LDO15_RS16900	COG0456	acetyltransferase
LDO15_RS16905	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LDO15_RS16925	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LDO15_RS16940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LDO15_RS16955	COG1473	amidohydrolase
LDO15_RS16990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LDO15_RS16995	COG0738	Major facilitator superfamily
LDO15_RS17005	COG2030	dehydratase
LDO15_RS17015	COG0659	secondary active sulfate transmembrane transporter activity
LDO15_RS17035	COG4989	oxidoreductase activity
LDO15_RS17040	COG0366	Alpha amylase catalytic
LDO15_RS17045	COG1940	carbohydrate kinase activity
LDO15_RS17055	COG0702	epimerase
LDO15_RS17085	COG4974	Belongs to the 'phage' integrase family
LDO15_RS17245	COG2304	oxidoreductase activity
LDO15_RS17295	COG1960	acyl-CoA dehydrogenase activity
LDO15_RS17310	COG5650	phosphatidylinositol metabolic process
LDO15_RS17335	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LDO15_RS17355	COG0318	PFAM AMP-dependent synthetase and ligase
LDO15_RS17365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDO15_RS17375	COG3340	Belongs to the peptidase S51 family
LDO15_RS17385	COG0346	lactoylglutathione lyase activity
LDO15_RS17395	COG1285	pathogenesis
LDO15_RS17400	COG3559	Exporter of polyketide antibiotics
LDO15_RS17405	COG1131	(ABC) transporter
LDO15_RS17425	COG2318	DinB family
LDO15_RS17445	COG1666	GTP binding
LDO15_RS17450	COG0501	Belongs to the peptidase M48B family
LDO15_RS17480	COG0531	amino acid
LDO15_RS17510	COG0154	amidase activity
LDO15_RS17555	COG1012	belongs to the aldehyde dehydrogenase family
LDO15_RS17560	COG3835	regulator
LDO15_RS17570	COG2186	Transcriptional regulator
LDO15_RS17580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LDO15_RS17610	COG1648	precorrin-2 dehydrogenase activity
LDO15_RS17610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LDO15_RS17630	COG1116	anion transmembrane transporter activity
LDO15_RS17655	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LDO15_RS17665	COG2860	membrane
LDO15_RS17680	COG0142	geranyltranstransferase activity
LDO15_RS17685	COG0644	oxidoreductase
LDO15_RS17690	COG2226	methyltransferase
LDO15_RS17695	COG1169	isochorismate synthase
LDO15_RS17705	COG0765	amino acid transport
LDO15_RS17710	COG1126	abc transporter atp-binding protein
LDO15_RS17720	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LDO15_RS17725	COG0018	arginyl-trna synthetase
LDO15_RS17735	COG1846	Transcriptional regulator
LDO15_RS17740	COG4948	Mandelate Racemase Muconate Lactonizing
LDO15_RS17750	COG3764	Sortase (surface protein transpeptidase)
LDO15_RS17810	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO15_RS17815	COG0022	dehydrogenase e1 component
LDO15_RS17830	COG0489	protein tyrosine kinase activity
LDO15_RS17845	COG1484	DNA-dependent DNA replication
LDO15_RS17910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LDO15_RS17915	COG1024	Enoyl-CoA hydratase
LDO15_RS17920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDO15_RS17925	COG2151	metal-sulfur cluster biosynthetic enzyme
LDO15_RS17930	COG3396	Phenylacetate-CoA oxygenase
LDO15_RS17935	COG3460	Phenylacetate-CoA oxygenase
LDO15_RS17940	COG3396	Phenylacetate-CoA oxygenase
LDO15_RS17955	COG0681	Belongs to the peptidase S26 family
LDO15_RS17960	COG0489	protein tyrosine kinase activity
LDO15_RS17975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDO15_RS18020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LDO15_RS18025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LDO15_RS18030	COG0857	belongs to the CobB CobQ family
LDO15_RS18030	COG0280	phosphate acetyltransferase
LDO15_RS18035	COG2050	protein possibly involved in aromatic compounds catabolism
LDO15_RS18065	COG1012	belongs to the aldehyde dehydrogenase family
LDO15_RS18065	COG2030	dehydratase
LDO15_RS18070	COG2050	protein possibly involved in aromatic compounds catabolism
LDO15_RS18075	COG1017	nitric oxide dioxygenase activity
LDO15_RS18075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDO15_RS18105	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDO15_RS18110	COG1024	Enoyl-CoA hydratase
LDO15_RS18115	COG0183	Belongs to the thiolase family
LDO15_RS18155	COG1802	Transcriptional regulator
LDO15_RS18170	COG3971	2-oxopent-4-enoate hydratase activity
LDO15_RS18185	COG0488	(ABC) transporter
LDO15_RS18200	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LDO15_RS18230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LDO15_RS18240	COG0785	Cytochrome C biogenesis protein
LDO15_RS18245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDO15_RS18250	COG0406	alpha-ribazole phosphatase activity
LDO15_RS18255	COG2353	YceI-like domain
LDO15_RS18270	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LDO15_RS18285	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LDO15_RS18310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LDO15_RS18320	COG0640	Transcriptional regulator
LDO15_RS18325	COG0123	including yeast histone deacetylase and acetoin utilization protein
LDO15_RS18330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LDO15_RS18335	COG0569	domain protein
LDO15_RS18345	COG4941	Belongs to the sigma-70 factor family
LDO15_RS18355	COG0248	Ppx GppA phosphatase
LDO15_RS18365	COG1754	DNA topoisomerase type I activity
LDO15_RS18365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LDO15_RS18385	COG2890	protein-(glutamine-N5) methyltransferase activity
LDO15_RS18405	COG1054	Belongs to the UPF0176 family
LDO15_RS18415	COG1205	dead DEAH box helicase
LDO15_RS18415	COG1111	helicase
LDO15_RS18470	COG0494	nUDIX hydrolase
LDO15_RS18485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDO15_RS18490	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LDO15_RS18525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LDO15_RS18530	COG1408	metallophosphoesterase
LDO15_RS18535	COG1132	(ABC) transporter
LDO15_RS18540	COG1132	(ABC) transporter
LDO15_RS18560	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LDO15_RS18565	COG0151	Belongs to the GarS family
LDO15_RS18585	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS18600	COG3387	PFAM Glycoside hydrolase 15-related
LDO15_RS18605	COG0667	Aldo Keto reductase
LDO15_RS18650	COG0671	phosphoesterase, PA-phosphatase related
LDO15_RS18660	COG0667	Aldo Keto reductase
LDO15_RS18665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDO15_RS18710	COG0693	protein deglycase activity
LDO15_RS18745	COG2197	response regulator
LDO15_RS18775	COG2084	Dehydrogenase
LDO15_RS18780	COG1082	Xylose isomerase domain protein TIM barrel
LDO15_RS18785	COG0149	triose-phosphate isomerase activity
LDO15_RS18790	COG0698	ribose 5-phosphate isomerase
LDO15_RS18795	COG2376	Dihydroxyacetone kinase
LDO15_RS18820	COG0673	inositol 2-dehydrogenase activity
LDO15_RS18830	COG1175	transmembrane transport
LDO15_RS18835	COG1653	transport
LDO15_RS18840	COG1609	Transcriptional regulator
LDO15_RS18845	COG1070	Carbohydrate kinase
LDO15_RS18850	COG2115	Belongs to the xylose isomerase family
LDO15_RS18855	COG0277	FAD linked oxidase domain protein
LDO15_RS18860	COG1940	carbohydrate kinase activity
LDO15_RS18865	COG2017	converts alpha-aldose to the beta-anomer
LDO15_RS18875	COG0346	lactoylglutathione lyase activity
LDO15_RS18885	COG0800	Aldolase
LDO15_RS18895	COG0395	ABC-type sugar transport system, permease component
LDO15_RS18900	COG1175	transmembrane transport
LDO15_RS18920	COG4670	ketone body catabolic process
LDO15_RS18930	COG1024	Enoyl-CoA hydratase
LDO15_RS18935	COG1012	belongs to the aldehyde dehydrogenase family
LDO15_RS18940	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
LDO15_RS18955	COG4702	Belongs to the UPF0303 family
LDO15_RS18970	COG0673	inositol 2-dehydrogenase activity
LDO15_RS18975	COG1609	Transcriptional regulator
LDO15_RS18990	COG2084	Dehydrogenase
LDO15_RS18995	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LDO15_RS19000	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LDO15_RS19005	COG0673	inositol 2-dehydrogenase activity
LDO15_RS19025	COG0318	PFAM AMP-dependent synthetase and ligase
LDO15_RS19030	COG2814	Major facilitator Superfamily
LDO15_RS19035	COG1414	Transcriptional regulator
LDO15_RS19040	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDO15_RS19045	COG0477	Major facilitator Superfamily
LDO15_RS19055	COG2508	Transcriptional regulator
LDO15_RS19055	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LDO15_RS19060	COG2066	Belongs to the glutaminase family
LDO15_RS19075	COG0028	Belongs to the TPP enzyme family
LDO15_RS19080	COG2986	histidine ammonia-lyase
LDO15_RS19085	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS19095	COG2318	DinB family
LDO15_RS19125	COG2130	NADP-dependent
LDO15_RS19140	COG0251	oxidation-reduction process
LDO15_RS19145	COG1126	abc transporter atp-binding protein
LDO15_RS19150	COG0765	amino acid transport
LDO15_RS19170	COG2508	Transcriptional regulator
LDO15_RS19200	COG1063	alcohol dehydrogenase
LDO15_RS19205	COG0395	ABC-type sugar transport system, permease component
LDO15_RS19240	COG0546	phosphoglycolate phosphatase activity
LDO15_RS19250	COG1063	alcohol dehydrogenase
LDO15_RS19255	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS19265	COG4221	oxidoreductase activity
LDO15_RS19270	COG0477	Major facilitator Superfamily
LDO15_RS19280	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LDO15_RS19285	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LDO15_RS19290	COG0583	DNA-binding transcription factor activity
LDO15_RS19300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LDO15_RS19305	COG0436	Aminotransferase
LDO15_RS19325	COG3795	YCII-related domain
LDO15_RS19330	COG1737	Transcriptional regulator
LDO15_RS19340	COG1012	belongs to the aldehyde dehydrogenase family
LDO15_RS19355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDO15_RS19370	COG0174	glutamine synthetase
LDO15_RS19390	COG0300	oxidoreductase activity
LDO15_RS19400	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LDO15_RS19430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDO15_RS19440	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDO15_RS19455	COG0583	DNA-binding transcription factor activity
LDO15_RS19475	COG0673	inositol 2-dehydrogenase activity
LDO15_RS19480	COG1940	carbohydrate kinase activity
LDO15_RS19540	COG3622	Belongs to the hyi family
LDO15_RS19550	COG0395	ABC-type sugar transport system, permease component
LDO15_RS19585	COG3845	ABC transporter
LDO15_RS19595	COG1410	methionine synthase
LDO15_RS19595	COG0646	methionine synthase
LDO15_RS19645	COG2022	thiamine diphosphate biosynthetic process
LDO15_RS19655	COG0647	UMP catabolic process
LDO15_RS19685	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LDO15_RS19730	COG0191	fructose-bisphosphate aldolase activity
LDO15_RS19735	COG0698	ribose 5-phosphate isomerase
LDO15_RS19740	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LDO15_RS19745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LDO15_RS19750	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LDO15_RS19755	COG2197	response regulator
LDO15_RS19830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDO15_RS19910	COG2076	Multidrug Resistance protein
LDO15_RS19960	COG2828	Protein conserved in bacteria
LDO15_RS19970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDO15_RS19975	COG0579	oxidoreductase
LDO15_RS19985	COG0745	RESPONSE REGULATOR receiver
LDO15_RS19990	COG5002	protein histidine kinase activity
LDO15_RS20000	COG0438	transferase activity, transferring glycosyl groups
LDO15_RS20005	COG0438	transferase activity, transferring glycosyl groups
LDO15_RS20010	COG1132	(ABC) transporter
LDO15_RS20050	COG2271	Major facilitator Superfamily
LDO15_RS20055	COG1802	Transcriptional regulator
LDO15_RS20065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LDO15_RS20075	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LDO15_RS20095	COG0667	Aldo Keto reductase
LDO15_RS20100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LDO15_RS20110	COG3608	succinylglutamate desuccinylase aspartoacylase
LDO15_RS20110	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LDO15_RS20115	COG0590	tRNA wobble adenosine to inosine editing
LDO15_RS20130	COG2233	PERMEase
LDO15_RS20135	COG1414	Transcriptional regulator
LDO15_RS20145	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LDO15_RS20155	COG3257	ureidoglycine aminohydrolase activity
LDO15_RS20165	COG3622	Belongs to the hyi family
LDO15_RS20170	COG2084	Dehydrogenase
LDO15_RS20175	COG3960	tartronate-semialdehyde synthase activity
LDO15_RS20180	COG1929	Belongs to the glycerate kinase type-1 family
LDO15_RS20185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LDO15_RS20190	COG0745	RESPONSE REGULATOR receiver
LDO15_RS20215	COG2226	methyltransferase
LDO15_RS20230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LDO15_RS20255	COG1609	Transcriptional regulator
LDO15_RS20265	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS20270	COG3246	L-lysine catabolic process to acetate
LDO15_RS20275	COG1929	Belongs to the glycerate kinase type-1 family
LDO15_RS20280	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LDO15_RS20300	COG3585	molybdate ion transport
LDO15_RS20325	COG2353	YceI-like domain
LDO15_RS20380	COG0135	phosphoribosylanthranilate isomerase activity
LDO15_RS20390	COG1177	transmembrane transport
LDO15_RS20395	COG1176	ABC-type spermidine putrescine transport system, permease component I
LDO15_RS20400	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LDO15_RS20405	COG3842	ATPase activity
LDO15_RS20425	COG2076	Multidrug Resistance protein
LDO15_RS20430	COG0667	Aldo Keto reductase
LDO15_RS20440	COG0513	Belongs to the DEAD box helicase family
LDO15_RS20450	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LDO15_RS20505	COG1113	amino acid transport
LDO15_RS20520	COG1473	amidohydrolase
LDO15_RS20525	COG0477	Major facilitator Superfamily
LDO15_RS20530	COG2807	transmembrane transport
LDO15_RS20535	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LDO15_RS20565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LDO15_RS20580	COG3226	Transcriptional regulator
LDO15_RS20590	COG0494	nUDIX hydrolase
LDO15_RS20615	COG1012	belongs to the aldehyde dehydrogenase family
LDO15_RS20630	COG0789	Transcriptional regulator
LDO15_RS20635	COG0484	heat shock protein binding
LDO15_RS20640	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LDO15_RS20645	COG0443	Heat shock 70 kDa protein
LDO15_RS20665	COG2409	Drug exporters of the RND superfamily
LDO15_RS20700	COG1280	lysine exporter protein (LysE YggA)
LDO15_RS20710	COG0477	Major facilitator Superfamily
LDO15_RS20720	COG1960	acyl-CoA dehydrogenase activity
LDO15_RS20730	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS20740	COG3387	PFAM Glycoside hydrolase 15-related
LDO15_RS20750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDO15_RS20760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LDO15_RS20790	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LDO15_RS20795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LDO15_RS20805	COG1122	ATPase activity
LDO15_RS20810	COG4721	ABC-type cobalt transport system, permease component
LDO15_RS20815	COG4702	Belongs to the UPF0303 family
LDO15_RS20830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LDO15_RS20835	COG1320	monovalent cation:proton antiporter activity
LDO15_RS20840	COG2212	antiporter activity
LDO15_RS20845	COG1863	multisubunit Na H antiporter MnhE subunit
LDO15_RS20850	COG0651	ATP synthesis coupled electron transport
LDO15_RS20855	COG1006	Multisubunit Na H antiporter MnhC subunit
LDO15_RS20860	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LDO15_RS20860	COG2111	Na H antiporter
LDO15_RS20875	COG0475	glutathione-regulated potassium exporter activity
LDO15_RS20880	COG0717	Belongs to the dCTP deaminase family
LDO15_RS20905	COG2814	Major facilitator Superfamily
LDO15_RS20910	COG0583	DNA-binding transcription factor activity
LDO15_RS20920	COG1012	belongs to the aldehyde dehydrogenase family
LDO15_RS20925	COG0531	amino acid
LDO15_RS20935	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LDO15_RS20955	COG3387	PFAM Glycoside hydrolase 15-related
LDO15_RS20970	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
LDO15_RS20980	COG1175	transmembrane transport
LDO15_RS20990	COG1609	Transcriptional regulator
LDO15_RS21010	COG0395	ABC-type sugar transport system, permease component
LDO15_RS21020	COG1349	DNA-binding transcription factor activity
LDO15_RS21035	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LDO15_RS21040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO15_RS21055	COG0433	COG0433 Predicted ATPase
LDO15_RS21075	COG3336	cytochrome c oxidase
LDO15_RS21080	COG0776	regulation of translation
LDO15_RS21120	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LDO15_RS21125	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LDO15_RS21130	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LDO15_RS21135	COG1017	nitric oxide dioxygenase activity
LDO15_RS21135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDO15_RS21190	COG1012	belongs to the aldehyde dehydrogenase family
LDO15_RS21205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO15_RS21220	COG1960	acyl-CoA dehydrogenase activity
LDO15_RS21225	COG1012	belongs to the aldehyde dehydrogenase family
LDO15_RS21230	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDO15_RS21275	COG3012	SEC-C Motif Domain Protein
LDO15_RS21285	COG0667	Aldo Keto reductase
LDO15_RS21290	COG0702	epimerase
LDO15_RS21305	COG0698	ribose 5-phosphate isomerase
LDO15_RS21310	COG2376	Dihydroxyacetone kinase
LDO15_RS21315	COG1028	Short-chain dehydrogenase reductase Sdr
LDO15_RS21325	COG0477	Major facilitator Superfamily
LDO15_RS21330	COG3959	Transketolase, thiamine diphosphate binding domain
LDO15_RS21335	COG3958	Transketolase
LDO15_RS21420	COG0039	L-malate dehydrogenase activity
LDO15_RS21430	COG0640	Transcriptional regulator
LDO15_RS21445	COG2186	Transcriptional regulator
LDO15_RS21455	COG1027	Aspartate ammonia-lyase
LDO15_RS21480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LDO15_RS21490	COG1522	sequence-specific DNA binding
LDO15_RS21495	COG1280	lysine exporter protein (LysE YggA)
LDO15_RS21515	COG0281	malic enzyme
LDO15_RS21520	COG1309	transcriptional regulator
LDO15_RS21530	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LDO15_RS21535	COG0477	Major facilitator Superfamily
LDO15_RS21540	COG0477	Major facilitator Superfamily
LDO15_RS21545	COG2814	Major facilitator Superfamily
LDO15_RS21555	COG0246	Mannitol dehydrogenase
LDO15_RS21560	COG2213	PTS system mannitol-specific
LDO15_RS21560	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDO15_RS21570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LDO15_RS21590	COG0686	Belongs to the AlaDH PNT family
LDO15_RS21595	COG0673	inositol 2-dehydrogenase activity
LDO15_RS21600	COG1309	transcriptional regulator
LDO15_RS21610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDO15_RS21620	COG0318	PFAM AMP-dependent synthetase and ligase
LDO15_RS21630	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO15_RS21635	COG0022	dehydrogenase e1 component
LDO15_RS21645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LDO15_RS21650	COG1950	PFAM Membrane protein of
LDO15_RS21665	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LDO15_RS21675	COG2902	Dehydrogenase
LDO15_RS21685	COG1607	acyl-coa hydrolase
LDO15_RS21705	COG2814	Major facilitator Superfamily
LDO15_RS21715	COG1970	mechanosensitive ion channel activity
LDO15_RS21750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LDO15_RS21755	COG1088	dTDP-glucose 4,6-dehydratase activity
LDO15_RS21760	COG0673	inositol 2-dehydrogenase activity
LDO15_RS21775	COG1414	Transcriptional regulator
LDO15_RS21780	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LDO15_RS21790	COG0183	Belongs to the thiolase family
LDO15_RS21795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LDO15_RS21805	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LDO15_RS21810	COG3485	protocatechuate 3,4-dioxygenase
LDO15_RS21815	COG3485	protocatechuate 3,4-dioxygenase
LDO15_RS21820	COG1082	Xylose isomerase domain protein TIM barrel
LDO15_RS21820	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LDO15_RS21825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDO15_RS21830	COG1414	Transcriptional regulator
LDO15_RS21840	COG1793	dna ligase
LDO15_RS21850	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LDO15_RS21870	COG1937	Protein conserved in bacteria
LDO15_RS21890	COG0697	spore germination
LDO15_RS21915	COG2259	Doxx family
LDO15_RS21920	COG1607	acyl-coa hydrolase
LDO15_RS21925	COG0305	Participates in initiation and elongation during chromosome replication
LDO15_RS21960	COG0359	binds to the 23S rRNA
LDO15_RS21965	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LDO15_RS21975	COG0360	Binds together with S18 to 16S ribosomal RNA
LDO15_RS21985	COG2197	response regulator
LDO15_RS21995	COG1215	transferase activity, transferring glycosyl groups
LDO15_RS22010	COG1215	transferase activity, transferring glycosyl groups
LDO15_RS22060	COG1362	aminopeptidase activity
LDO15_RS22070	COG1113	amino acid transport
LDO15_RS22075	COG2197	response regulator
LDO15_RS22080	COG4585	Histidine kinase
LDO15_RS22090	COG1131	(ABC) transporter
LDO15_RS22100	COG0738	Major facilitator superfamily
LDO15_RS22110	COG0488	(ABC) transporter
LDO15_RS22120	COG2197	response regulator
LDO15_RS22125	COG4585	Histidine kinase
LDO15_RS22135	COG1136	(ABC) transporter
LDO15_RS22155	COG0406	alpha-ribazole phosphatase activity
LDO15_RS22160	COG0617	tRNA 3'-terminal CCA addition
LDO15_RS22180	COG0492	ferredoxin-NADP+ reductase activity
LDO15_RS22185	COG3118	belongs to the thioredoxin family
LDO15_RS22200	COG1192	Involved in chromosome partitioning
LDO15_RS22205	COG0357	Ribosomal RNA small subunit methyltransferase G
LDO15_RS22215	COG0706	membrane insertase activity
LDO15_RS22220	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LDO15_RS22225	COG0594	ribonuclease P activity
LDO15_RS22230	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LDO15_RS22380	COG2186	Transcriptional regulator
LDO15_RS22385	COG0129	dihydroxy-acid dehydratase activity
LDO15_RS22400	COG0561	phosphatase activity
LDO15_RS22405	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LDO15_RS22410	COG3387	PFAM Glycoside hydrolase 15-related
LDO15_RS22415	COG2902	Dehydrogenase
LDO15_RS22420	COG3547	Transposase (IS116 IS110 IS902 family)
LDO15_RS22430	COG0154	amidase activity
LDO15_RS22445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDO15_RS22480	COG2233	PERMEase
LDO15_RS22495	COG0509	glycine decarboxylation via glycine cleavage system
LDO15_RS22500	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LDO15_RS22510	COG1879	ABC-type sugar transport system periplasmic component
LDO15_RS22515	COG0402	S-adenosylhomocysteine deaminase activity
LDO15_RS22530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDO15_RS22535	COG2233	PERMEase
LDO15_RS22560	COG1733	regulation of RNA biosynthetic process
LDO15_RS22565	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LDO15_RS22590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LDO15_RS22595	COG3246	L-lysine catabolic process to acetate
LDO15_RS22600	COG0318	PFAM AMP-dependent synthetase and ligase
LDO15_RS22605	COG0113	porphobilinogen synthase activity
LDO15_RS22615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LDO15_RS22635	COG3253	May function as heme-dependent peroxidase
LDO15_RS22725	COG2186	Transcriptional regulator
LDO15_RS22755	COG2826	transposase and inactivated derivatives, IS30 family
LDO15_RS22805	COG2233	PERMEase
LDO15_RS22810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDO15_RS22825	COG0402	S-adenosylhomocysteine deaminase activity
LDO15_RS22830	COG1879	ABC-type sugar transport system periplasmic component
LDO15_RS22835	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LDO15_RS22835	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LDO15_RS22840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LDO15_RS22845	COG0509	glycine decarboxylation via glycine cleavage system
LDO15_RS22850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LDO15_RS22860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LDO15_RS22870	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LDO15_RS22880	COG2233	PERMEase
LDO15_RS22895	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LDO15_RS22930	COG2814	Major facilitator Superfamily
LDO15_RS22975	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LDO15_RS23075	COG3706	GGDEF domain
LDO15_RS23095	COG3979	chitinase
LDO15_RS23170	COG3547	Transposase (IS116 IS110 IS902 family)
LDO15_RS23210	COG4152	abc transporter atp-binding protein
LDO15_RS23230	COG1475	DNA binding
LDO15_RS23315	COG0659	secondary active sulfate transmembrane transporter activity
LDO15_RS23330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LDO15_RS23395	COG1674	ftsk spoiiie
LDO15_RS23465	COG3979	chitinase