locus-tag	class	description
LDO22_RS00010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDO22_RS00055	COG1017	nitric oxide dioxygenase activity
LDO22_RS00055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDO22_RS00060	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LDO22_RS00065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LDO22_RS00070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LDO22_RS00090	COG1609	Transcriptional regulator
LDO22_RS00125	COG0647	UMP catabolic process
LDO22_RS00140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LDO22_RS00145	COG0497	DNA recombination
LDO22_RS00150	COG0504	CTP synthase activity
LDO22_RS00155	COG0494	nUDIX hydrolase
LDO22_RS00180	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LDO22_RS00185	COG2079	MmgE PrpD family protein
LDO22_RS00205	COG3290	protein histidine kinase activity
LDO22_RS00220	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LDO22_RS00225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LDO22_RS00240	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LDO22_RS00250	COG1160	GTP binding
LDO22_RS00265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LDO22_RS00270	COG0509	glycine decarboxylation via glycine cleavage system
LDO22_RS00275	COG1716	ATPase activity
LDO22_RS00300	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LDO22_RS00305	COG0464	growth
LDO22_RS00315	COG1940	carbohydrate kinase activity
LDO22_RS00340	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LDO22_RS00345	COG0515	serine threonine protein kinase
LDO22_RS00345	COG2815	serine threonine protein kinase
LDO22_RS00350	COG3942	CHAP domain
LDO22_RS00350	COG1388	LysM domain
LDO22_RS00360	COG0142	geranyltranstransferase activity
LDO22_RS00370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LDO22_RS00380	COG2001	Belongs to the MraZ family
LDO22_RS00385	COG0275	rRNA processing
LDO22_RS00395	COG0768	penicillin binding
LDO22_RS00400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LDO22_RS00410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LDO22_RS00415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LDO22_RS00420	COG0772	Belongs to the SEDS family
LDO22_RS00425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LDO22_RS00430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LDO22_RS00440	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LDO22_RS00450	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LDO22_RS00455	COG1799	cell septum assembly
LDO22_RS00465	COG3599	regulation of cell shape
LDO22_RS00470	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LDO22_RS00480	COG0587	DNA-directed DNA polymerase activity
LDO22_RS00495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LDO22_RS00500	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LDO22_RS00520	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LDO22_RS00525	COG0174	glutamine synthetase
LDO22_RS00530	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LDO22_RS00565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LDO22_RS00570	COG0321	lipoyl(octanoyl) transferase activity
LDO22_RS00580	COG1090	epimerase
LDO22_RS00585	COG4946	Tricorn protease homolog
LDO22_RS00585	COG0793	Belongs to the peptidase S41A family
LDO22_RS00590	COG1764	response to oxidative stress
LDO22_RS00600	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO22_RS00605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDO22_RS00610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LDO22_RS00630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LDO22_RS00655	COG1271	oxidase subunit
LDO22_RS00660	COG1294	oxidase, subunit
LDO22_RS00665	COG4988	ABC transporter
LDO22_RS00675	COG1131	(ABC) transporter
LDO22_RS00680	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LDO22_RS00685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LDO22_RS00685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LDO22_RS00700	COG1435	thymidine kinase activity
LDO22_RS00725	COG0756	dUTP diphosphatase activity
LDO22_RS00750	COG0569	domain protein
LDO22_RS00755	COG0531	amino acid
LDO22_RS00760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LDO22_RS00765	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LDO22_RS00770	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LDO22_RS00785	COG0667	Aldo Keto reductase
LDO22_RS00805	COG1122	ATPase activity
LDO22_RS00810	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDO22_RS00810	COG1024	Enoyl-CoA hydratase
LDO22_RS00815	COG0183	Belongs to the thiolase family
LDO22_RS00820	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LDO22_RS00845	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LDO22_RS00860	COG1012	belongs to the aldehyde dehydrogenase family
LDO22_RS00865	COG0300	oxidoreductase activity
LDO22_RS00870	COG2132	Multicopper oxidase
LDO22_RS00875	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LDO22_RS00895	COG3135	benzoate transporter
LDO22_RS00940	COG0242	peptide deformylase activity
LDO22_RS00945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LDO22_RS00955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LDO22_RS00970	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LDO22_RS00970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LDO22_RS00980	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LDO22_RS00985	COG0140	phosphoribosyl-ATP diphosphatase activity
LDO22_RS00990	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LDO22_RS00995	COG0107	imidazoleglycerol-phosphate synthase activity
LDO22_RS01005	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LDO22_RS01025	COG0134	indole-3-glycerol-phosphate synthase activity
LDO22_RS01030	COG0133	tryptophan synthase activity
LDO22_RS01035	COG0159	tryptophan synthase activity
LDO22_RS01040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LDO22_RS01045	COG0067	glutamate synthase
LDO22_RS01045	COG0069	glutamate synthase activity
LDO22_RS01045	COG0070	glutamate synthase
LDO22_RS01055	COG0469	pyruvate kinase activity
LDO22_RS01170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LDO22_RS01215	COG1609	Transcriptional regulator
LDO22_RS01220	COG2211	Major facilitator Superfamily
LDO22_RS01375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDO22_RS01385	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LDO22_RS01385	COG3608	succinylglutamate desuccinylase aspartoacylase
LDO22_RS01415	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LDO22_RS01465	COG2755	lipolytic protein G-D-S-L family
LDO22_RS01475	COG1349	DNA-binding transcription factor activity
LDO22_RS01490	COG0477	Major facilitator Superfamily
LDO22_RS01500	COG0800	Aldolase
LDO22_RS01510	COG1609	Transcriptional regulator
LDO22_RS01540	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS01550	COG0395	ABC-type sugar transport system, permease component
LDO22_RS01795	COG1472	Belongs to the glycosyl hydrolase 3 family
LDO22_RS01800	COG3250	beta-galactosidase activity
LDO22_RS01805	COG2814	Major facilitator Superfamily
LDO22_RS01825	COG3250	beta-galactosidase activity
LDO22_RS01835	COG1175	transmembrane transport
LDO22_RS01840	COG0395	ABC-type sugar transport system, permease component
LDO22_RS01845	COG4952	isomerase
LDO22_RS01850	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS01850	COG3347	Dehydrogenase
LDO22_RS01875	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS01880	COG4638	Rieske (2fe-2S)
LDO22_RS01890	COG0633	Ferredoxin
LDO22_RS01925	COG1012	belongs to the aldehyde dehydrogenase family
LDO22_RS01930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LDO22_RS01950	COG1309	transcriptional regulator
LDO22_RS01955	COG2365	Tyrosine phosphatase family
LDO22_RS01970	COG3619	membrane
LDO22_RS02020	COG2188	Transcriptional regulator
LDO22_RS02035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LDO22_RS02035	COG0574	Belongs to the PEP-utilizing enzyme family
LDO22_RS02055	COG0439	Biotin carboxylase
LDO22_RS02060	COG0511	ligase activity, forming carbon-carbon bonds
LDO22_RS02075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDO22_RS02085	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS02090	COG1414	Transcriptional regulator
LDO22_RS02095	COG2814	Major facilitator Superfamily
LDO22_RS02100	COG3485	protocatechuate 3,4-dioxygenase
LDO22_RS02105	COG0667	Aldo Keto reductase
LDO22_RS02110	COG1454	alcohol dehydrogenase
LDO22_RS02115	COG4214	carbohydrate transport
LDO22_RS02125	COG4213	ABC transporter substrate-binding protein
LDO22_RS02130	COG1414	Transcriptional regulator
LDO22_RS02135	COG0673	inositol 2-dehydrogenase activity
LDO22_RS02145	COG0673	inositol 2-dehydrogenase activity
LDO22_RS02160	COG0183	Belongs to the thiolase family
LDO22_RS02170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LDO22_RS02175	COG1017	nitric oxide dioxygenase activity
LDO22_RS02175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDO22_RS02220	COG2154	pterin-4-alpha-carbinolamine dehydratase
LDO22_RS02225	COG2188	Transcriptional regulator
LDO22_RS02230	COG1850	ribulose-bisphosphate carboxylase activity
LDO22_RS02240	COG1063	alcohol dehydrogenase
LDO22_RS02250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDO22_RS02255	COG0667	Aldo Keto reductase
LDO22_RS02260	COG1621	beta-fructofuranosidase activity
LDO22_RS02270	COG0395	ABC-type sugar transport system, permease component
LDO22_RS02275	COG4209	transmembrane transport
LDO22_RS02300	COG0395	ABC-type sugar transport system, permease component
LDO22_RS02305	COG1063	alcohol dehydrogenase
LDO22_RS02325	COG1268	BioY protein
LDO22_RS02360	COG0395	ABC-type sugar transport system, permease component
LDO22_RS02365	COG1175	transmembrane transport
LDO22_RS02375	COG1609	Transcriptional regulator
LDO22_RS02385	COG1621	beta-fructofuranosidase activity
LDO22_RS02395	COG0444	Belongs to the ABC transporter superfamily
LDO22_RS02400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO22_RS02405	COG0601	transmembrane transport
LDO22_RS02410	COG0747	negative chemotaxis
LDO22_RS02420	COG0667	Aldo Keto reductase
LDO22_RS02425	COG1621	beta-fructofuranosidase activity
LDO22_RS02480	COG1063	alcohol dehydrogenase
LDO22_RS02485	COG0583	DNA-binding transcription factor activity
LDO22_RS02515	COG0437	4 iron, 4 sulfur cluster binding
LDO22_RS02525	COG0709	Synthesizes selenophosphate from selenide and ATP
LDO22_RS02555	COG2124	cytochrome p450
LDO22_RS02575	COG3386	PFAM SMP-30 Gluconolaconase
LDO22_RS02580	COG0667	Aldo Keto reductase
LDO22_RS02600	COG0477	Major facilitator Superfamily
LDO22_RS02605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LDO22_RS02610	COG1024	Enoyl-CoA hydratase
LDO22_RS02615	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS02630	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LDO22_RS02645	COG0406	alpha-ribazole phosphatase activity
LDO22_RS02650	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LDO22_RS02670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LDO22_RS02675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LDO22_RS02690	COG1643	Atp-dependent helicase
LDO22_RS02705	COG0009	L-threonylcarbamoyladenylate synthase
LDO22_RS02755	COG2050	protein possibly involved in aromatic compounds catabolism
LDO22_RS02765	COG4552	Acetyltransferase involved in intracellular survival and related
LDO22_RS02770	COG0539	negative regulation of cytoplasmic translation
LDO22_RS02780	COG1739	Uncharacterized protein family UPF0029
LDO22_RS02785	COG0237	dephospho-CoA kinase activity
LDO22_RS02785	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LDO22_RS02790	COG0556	nucleotide-excision repair
LDO22_RS02800	COG0477	Major facilitator Superfamily
LDO22_RS02820	COG4106	trans-aconitate 2-methyltransferase activity
LDO22_RS02850	COG0204	Acyl-transferase
LDO22_RS02850	COG0318	PFAM AMP-dependent synthetase and ligase
LDO22_RS02855	COG0322	excinuclease ABC activity
LDO22_RS02860	COG1660	Displays ATPase and GTPase activities
LDO22_RS02865	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LDO22_RS02870	COG1481	regulation of sporulation
LDO22_RS02875	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LDO22_RS02880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LDO22_RS02885	COG0126	phosphoglycerate kinase activity
LDO22_RS02890	COG0149	triose-phosphate isomerase activity
LDO22_RS02895	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LDO22_RS02905	COG0363	glucosamine-6-phosphate deaminase activity
LDO22_RS02920	COG0166	Belongs to the GPI family
LDO22_RS02925	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LDO22_RS02935	COG0109	protoheme IX farnesyltransferase activity
LDO22_RS02940	COG0659	secondary active sulfate transmembrane transporter activity
LDO22_RS02945	COG1612	heme a metabolic process
LDO22_RS02955	COG1131	(ABC) transporter
LDO22_RS02980	COG0396	ATPase activity
LDO22_RS02985	COG2151	metal-sulfur cluster biosynthetic enzyme
LDO22_RS02995	COG0318	PFAM AMP-dependent synthetase and ligase
LDO22_RS03010	COG1122	ATPase activity
LDO22_RS03015	COG1268	BioY protein
LDO22_RS03030	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LDO22_RS03045	COG2354	Protein conserved in bacteria
LDO22_RS03055	COG0488	(ABC) transporter
LDO22_RS03080	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS03085	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS03090	COG3830	Belongs to the UPF0237 family
LDO22_RS03090	COG0560	Phosphoserine phosphatase
LDO22_RS03095	COG1119	ATPase activity
LDO22_RS03110	COG0254	rRNA binding
LDO22_RS03125	COG2855	membrane
LDO22_RS03140	COG1305	Transglutaminase-like
LDO22_RS03155	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LDO22_RS03160	COG0297	glycogen (starch) synthase activity
LDO22_RS03180	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS03200	COG0435	Glutathione S-transferase
LDO22_RS03235	COG1063	alcohol dehydrogenase
LDO22_RS03280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDO22_RS03300	COG0656	L-ascorbic acid biosynthetic process
LDO22_RS03305	COG1968	undecaprenyl-diphosphatase activity
LDO22_RS03310	COG0215	cysteine-tRNA ligase activity
LDO22_RS03320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDO22_RS03325	COG1994	Peptidase M50
LDO22_RS03325	COG0517	IMP dehydrogenase activity
LDO22_RS03335	COG1222	aaa ATPase
LDO22_RS03340	COG4122	O-methyltransferase activity
LDO22_RS03350	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LDO22_RS03355	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LDO22_RS03360	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LDO22_RS03365	COG0545	Peptidyl-prolyl cis-trans isomerase
LDO22_RS03385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LDO22_RS03390	COG0805	protein transport
LDO22_RS03395	COG4581	dead DEAH box helicase
LDO22_RS03400	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LDO22_RS03405	COG1216	Glycosyl transferase, family 2
LDO22_RS03430	COG0242	peptide deformylase activity
LDO22_RS03440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDO22_RS03445	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LDO22_RS03470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LDO22_RS03475	COG1845	cytochrome c oxidase, subunit III
LDO22_RS03480	COG2010	Cytochrome c
LDO22_RS03485	COG0723	plastoquinol--plastocyanin reductase activity
LDO22_RS03490	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LDO22_RS03510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LDO22_RS03515	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LDO22_RS03535	COG0167	dihydroorotate dehydrogenase activity
LDO22_RS03545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LDO22_RS03550	COG1381	Involved in DNA repair and RecF pathway recombination
LDO22_RS03555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LDO22_RS03560	COG3590	peptidase
LDO22_RS03565	COG1316	TRANSCRIPTIONal
LDO22_RS03570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LDO22_RS03580	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LDO22_RS03595	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LDO22_RS03600	COG0484	heat shock protein binding
LDO22_RS03605	COG1420	regulation of RNA biosynthetic process
LDO22_RS03625	COG0481	GTPase activity
LDO22_RS03635	COG0268	Binds directly to 16S ribosomal RNA
LDO22_RS03650	COG1555	photosystem II stabilization
LDO22_RS03670	COG1307	EDD domain protein, DegV family
LDO22_RS03675	COG0495	leucyl-tRNA aminoacylation
LDO22_RS03680	COG0723	plastoquinol--plastocyanin reductase activity
LDO22_RS03685	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LDO22_RS03690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LDO22_RS03695	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LDO22_RS03700	COG2390	Transcriptional regulator
LDO22_RS03705	COG0656	L-ascorbic acid biosynthetic process
LDO22_RS03715	COG0438	transferase activity, transferring glycosyl groups
LDO22_RS03725	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LDO22_RS03735	COG1758	RNA polymerase activity
LDO22_RS03740	COG0194	GDP metabolic process
LDO22_RS03745	COG0194	GDP metabolic process
LDO22_RS03750	COG0284	orotidine-5'-phosphate decarboxylase activity
LDO22_RS03755	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LDO22_RS03760	COG0505	Belongs to the CarA family
LDO22_RS03770	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LDO22_RS03775	COG0540	Belongs to the ATCase OTCase family
LDO22_RS03780	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LDO22_RS03790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LDO22_RS03795	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LDO22_RS03805	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LDO22_RS03810	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LDO22_RS03815	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LDO22_RS03820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDO22_RS03835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LDO22_RS03850	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LDO22_RS03875	COG1053	succinate dehydrogenase
LDO22_RS03885	COG0477	Major facilitator Superfamily
LDO22_RS03895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LDO22_RS03905	COG0124	histidyl-tRNA synthetase
LDO22_RS03910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LDO22_RS03915	COG1196	nuclear chromosome segregation
LDO22_RS03925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LDO22_RS03930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LDO22_RS03935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LDO22_RS03945	COG2255	four-way junction helicase activity
LDO22_RS03950	COG0632	four-way junction helicase activity
LDO22_RS03955	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LDO22_RS03960	COG0217	transcriptional regulatory protein
LDO22_RS03965	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LDO22_RS03970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LDO22_RS03980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDO22_RS03990	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LDO22_RS03995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LDO22_RS04005	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LDO22_RS04010	COG0587	DNA-directed DNA polymerase activity
LDO22_RS04025	COG0077	Prephenate dehydratase
LDO22_RS04025	COG1605	Chorismate mutase
LDO22_RS04035	COG2135	peptidase activity
LDO22_RS04050	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LDO22_RS04055	COG1695	Transcriptional regulator
LDO22_RS04085	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS04115	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LDO22_RS04120	COG1234	tRNA 3'-trailer cleavage
LDO22_RS04140	COG0589	response to stress
LDO22_RS04205	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LDO22_RS04215	COG0574	Belongs to the PEP-utilizing enzyme family
LDO22_RS04215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LDO22_RS04220	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LDO22_RS04230	COG2217	Heavy metal translocating P-type atpase
LDO22_RS04345	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LDO22_RS04355	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LDO22_RS04545	COG3209	COG3209 Rhs family protein
LDO22_RS04605	COG4152	abc transporter atp-binding protein
LDO22_RS04655	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LDO22_RS04660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LDO22_RS04665	COG1780	Probably involved in ribonucleotide reductase function
LDO22_RS04680	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LDO22_RS04695	COG0583	DNA-binding transcription factor activity
LDO22_RS04715	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LDO22_RS04740	COG0714	Associated with various cellular activities
LDO22_RS04755	COG1175	transmembrane transport
LDO22_RS04770	COG2813	Specifically methylates the guanine in position
LDO22_RS04775	COG0492	ferredoxin-NADP+ reductase activity
LDO22_RS04780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LDO22_RS04805	COG0799	negative regulation of ribosome biogenesis
LDO22_RS04815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LDO22_RS04825	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LDO22_RS04830	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LDO22_RS04835	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LDO22_RS04840	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LDO22_RS04845	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LDO22_RS04850	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LDO22_RS04850	COG0351	phosphomethylpyrimidine kinase
LDO22_RS04850	COG0352	thiamine-phosphate diphosphorylase activity
LDO22_RS04855	COG1530	ribonuclease E activity
LDO22_RS04865	COG0105	UTP biosynthetic process
LDO22_RS04875	COG0285	dihydrofolate synthase activity
LDO22_RS04880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LDO22_RS04895	COG0525	valine-tRNA ligase activity
LDO22_RS04900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LDO22_RS04905	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LDO22_RS04910	COG0740	serine-type endopeptidase activity
LDO22_RS04915	COG0740	serine-type endopeptidase activity
LDO22_RS04920	COG0544	peptidyl-prolyl cis-trans isomerase activity
LDO22_RS04965	COG0668	transmembrane transport
LDO22_RS04980	COG1946	Acyl-CoA thioesterase
LDO22_RS04995	COG0629	single-stranded DNA binding
LDO22_RS05025	COG1475	DNA binding
LDO22_RS05225	COG4974	Belongs to the 'phage' integrase family
LDO22_RS05240	COG2115	Belongs to the xylose isomerase family
LDO22_RS05245	COG1070	Carbohydrate kinase
LDO22_RS05260	COG0673	inositol 2-dehydrogenase activity
LDO22_RS05265	COG1609	Transcriptional regulator
LDO22_RS05270	COG2755	lipolytic protein G-D-S-L family
LDO22_RS05270	COG0657	acetylesterase activity
LDO22_RS05275	COG2017	converts alpha-aldose to the beta-anomer
LDO22_RS05290	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LDO22_RS05300	COG0242	peptide deformylase activity
LDO22_RS05330	COG3022	response to hydroperoxide
LDO22_RS05340	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LDO22_RS05345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LDO22_RS05355	COG1045	serine acetyltransferase
LDO22_RS05360	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS05365	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LDO22_RS05400	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LDO22_RS05415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LDO22_RS05420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LDO22_RS05425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LDO22_RS05435	COG4974	Belongs to the 'phage' integrase family
LDO22_RS05450	COG0792	nuclease activity
LDO22_RS05460	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LDO22_RS05470	COG0681	Belongs to the peptidase S26 family
LDO22_RS05475	COG0335	large ribosomal subunit rRNA binding
LDO22_RS05480	COG0336	Belongs to the RNA methyltransferase TrmD family
LDO22_RS05485	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LDO22_RS05490	COG1837	Belongs to the UPF0109 family
LDO22_RS05495	COG0228	four-way junction DNA binding
LDO22_RS05505	COG2514	catechol 2,3-dioxygenase activity
LDO22_RS05530	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LDO22_RS05545	COG2814	Major facilitator Superfamily
LDO22_RS05560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LDO22_RS05565	COG0318	PFAM AMP-dependent synthetase and ligase
LDO22_RS05570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDO22_RS05595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LDO22_RS05600	COG0571	ribonuclease III activity
LDO22_RS05605	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LDO22_RS05615	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LDO22_RS05630	COG0742	ribosomal rna small subunit methyltransferase
LDO22_RS05635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LDO22_RS05640	COG1461	Dihydroxyacetone kinase
LDO22_RS05655	COG1181	Belongs to the D-alanine--D-alanine ligase family
LDO22_RS05660	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LDO22_RS05670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LDO22_RS05675	COG0066	3-isopropylmalate dehydratase activity
LDO22_RS05680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LDO22_RS05685	COG1414	Transcriptional regulator
LDO22_RS05730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LDO22_RS05735	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDO22_RS05740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDO22_RS05750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LDO22_RS05755	COG0473	3-isopropylmalate dehydrogenase activity
LDO22_RS05765	COG0577	efflux transmembrane transporter activity
LDO22_RS05765	COG1136	(ABC) transporter
LDO22_RS05775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDO22_RS05780	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LDO22_RS05785	COG0440	acetolactate synthase activity
LDO22_RS05795	COG0129	dihydroxy-acid dehydratase activity
LDO22_RS05800	COG0088	Forms part of the polypeptide exit tunnel
LDO22_RS05835	COG0747	negative chemotaxis
LDO22_RS05840	COG0579	oxidoreductase
LDO22_RS05845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LDO22_RS05850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO22_RS05860	COG1305	Transglutaminase-like
LDO22_RS05880	COG1104	cysteine desulfurase activity
LDO22_RS05890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LDO22_RS05895	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LDO22_RS05905	COG1113	amino acid transport
LDO22_RS05915	COG0477	Major facilitator Superfamily
LDO22_RS05930	COG0419	ATPase involved in DNA repair
LDO22_RS05935	COG0420	3'-5' exonuclease activity
LDO22_RS05960	COG0586	Pfam SNARE associated Golgi protein
LDO22_RS05965	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LDO22_RS05970	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LDO22_RS05975	COG1234	tRNA 3'-trailer cleavage
LDO22_RS05980	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LDO22_RS05990	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LDO22_RS06000	COG1335	isochorismatase
LDO22_RS06015	COG0363	glucosamine-6-phosphate deaminase activity
LDO22_RS06040	COG1902	pentaerythritol trinitrate reductase activity
LDO22_RS06055	COG0628	permease
LDO22_RS06070	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
LDO22_RS06080	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LDO22_RS06085	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LDO22_RS06095	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LDO22_RS06100	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LDO22_RS06105	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LDO22_RS06110	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LDO22_RS06115	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LDO22_RS06120	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LDO22_RS06125	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LDO22_RS06130	COG0356	it plays a direct role in the translocation of protons across the membrane
LDO22_RS06150	COG1216	Glycosyl transferase, family 2
LDO22_RS06165	COG2890	protein-(glutamine-N5) methyltransferase activity
LDO22_RS06170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LDO22_RS06180	COG0083	homoserine kinase activity
LDO22_RS06185	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LDO22_RS06190	COG0460	homoserine dehydrogenase
LDO22_RS06195	COG0019	diaminopimelate decarboxylase activity
LDO22_RS06200	COG0018	arginyl-trna synthetase
LDO22_RS06215	COG1017	nitric oxide dioxygenase activity
LDO22_RS06215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDO22_RS06240	COG1643	Atp-dependent helicase
LDO22_RS06245	COG0537	adenosine 5'-monophosphoramidase activity
LDO22_RS06250	COG1064	alcohol dehydrogenase
LDO22_RS06260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LDO22_RS06280	COG3842	ATPase activity
LDO22_RS06285	COG0803	Belongs to the bacterial solute-binding protein 9 family
LDO22_RS06300	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO22_RS06300	COG0567	Dehydrogenase, E1 component
LDO22_RS06325	COG1595	DNA-templated transcription, initiation
LDO22_RS06335	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LDO22_RS06345	COG0483	inositol monophosphate 1-phosphatase activity
LDO22_RS06350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LDO22_RS06370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LDO22_RS06385	COG1063	alcohol dehydrogenase
LDO22_RS06420	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LDO22_RS06435	COG2884	Cell division ATP-binding protein ftsE
LDO22_RS06440	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LDO22_RS06480	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LDO22_RS06480	COG5479	isomerase activity
LDO22_RS06485	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LDO22_RS06490	COG1088	dTDP-glucose 4,6-dehydratase activity
LDO22_RS06500	COG1216	Glycosyl transferase, family 2
LDO22_RS06515	COG1215	transferase activity, transferring glycosyl groups
LDO22_RS06560	COG1216	Glycosyl transferase, family 2
LDO22_RS06595	COG2902	Dehydrogenase
LDO22_RS06630	COG0653	protein targeting
LDO22_RS06635	COG3214	Protein conserved in bacteria
LDO22_RS06640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LDO22_RS06650	COG5401	PFAM Sporulation and spore germination
LDO22_RS06655	COG5002	protein histidine kinase activity
LDO22_RS06680	COG0714	Associated with various cellular activities
LDO22_RS06715	COG0601	transmembrane transport
LDO22_RS06725	COG0482	sulfurtransferase activity
LDO22_RS06750	COG0484	heat shock protein binding
LDO22_RS06755	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LDO22_RS06760	COG1595	DNA-templated transcription, initiation
LDO22_RS06775	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LDO22_RS06780	COG2086	electron transfer activity
LDO22_RS06785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LDO22_RS06795	COG1842	Phage shock protein A
LDO22_RS06800	COG0415	Belongs to the DNA photolyase family
LDO22_RS06820	COG1615	UPF0182 protein
LDO22_RS06825	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LDO22_RS06845	COG2816	NAD+ diphosphatase activity
LDO22_RS06855	COG0210	DNA helicase
LDO22_RS06875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDO22_RS06880	COG0765	amino acid transport
LDO22_RS06885	COG1126	abc transporter atp-binding protein
LDO22_RS06890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LDO22_RS06900	COG0113	porphobilinogen synthase activity
LDO22_RS06910	COG0181	hydroxymethylbilane synthase activity
LDO22_RS06915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LDO22_RS06920	COG3253	May function as heme-dependent peroxidase
LDO22_RS06945	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LDO22_RS06950	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LDO22_RS06975	COG2022	thiamine diphosphate biosynthetic process
LDO22_RS06985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDO22_RS06985	COG2022	thiamine diphosphate biosynthetic process
LDO22_RS06990	COG0352	thiamine-phosphate diphosphorylase activity
LDO22_RS06995	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LDO22_RS07000	COG0513	Belongs to the DEAD box helicase family
LDO22_RS07005	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LDO22_RS07015	COG0006	proline dipeptidase activity
LDO22_RS07025	COG2239	Acts as a magnesium transporter
LDO22_RS07040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LDO22_RS07050	COG1595	DNA-templated transcription, initiation
LDO22_RS07075	COG1611	Belongs to the LOG family
LDO22_RS07080	COG1126	abc transporter atp-binding protein
LDO22_RS07085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDO22_RS07090	COG0765	amino acid transport
LDO22_RS07095	COG0765	amino acid transport
LDO22_RS07100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDO22_RS07105	COG2171	N-acyltransferase activity
LDO22_RS07120	COG3226	Transcriptional regulator
LDO22_RS07125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LDO22_RS07155	COG1217	gtp-binding protein TYPA
LDO22_RS07170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO22_RS07180	COG4166	transmembrane transport
LDO22_RS07190	COG3152	Membrane
LDO22_RS07195	COG0012	GTP binding
LDO22_RS07200	COG1322	Protein conserved in bacteria
LDO22_RS07205	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LDO22_RS07215	COG1570	exodeoxyribonuclease VII activity
LDO22_RS07220	COG1722	exodeoxyribonuclease VII activity
LDO22_RS07225	COG2326	polyphosphate kinase activity
LDO22_RS07240	COG1174	glycine betaine transport
LDO22_RS07245	COG1174	glycine betaine transport
LDO22_RS07250	COG1125	glycine betaine transport
LDO22_RS07250	COG0517	IMP dehydrogenase activity
LDO22_RS07260	COG2971	BadF BadG BcrA BcrD
LDO22_RS07265	COG0583	DNA-binding transcription factor activity
LDO22_RS07270	COG2814	Major facilitator Superfamily
LDO22_RS07290	COG0598	Magnesium transport protein CorA
LDO22_RS07305	COG3848	Pyruvate phosphate dikinase
LDO22_RS07305	COG0574	Belongs to the PEP-utilizing enzyme family
LDO22_RS07330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LDO22_RS07335	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LDO22_RS07355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LDO22_RS07355	COG0519	Catalyzes the synthesis of GMP from XMP
LDO22_RS07375	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LDO22_RS07380	COG0516	GMP reductase activity
LDO22_RS07415	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LDO22_RS07415	COG2755	lipolytic protein G-D-S-L family
LDO22_RS07425	COG1793	dna ligase
LDO22_RS07435	COG0459	protein refolding
LDO22_RS07440	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LDO22_RS07455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDO22_RS07460	COG1472	Belongs to the glycosyl hydrolase 3 family
LDO22_RS07465	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LDO22_RS07470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LDO22_RS07485	COG0802	atpase or kinase
LDO22_RS07490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LDO22_RS07505	COG0438	transferase activity, transferring glycosyl groups
LDO22_RS07510	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LDO22_RS07525	COG0667	Aldo Keto reductase
LDO22_RS07550	COG0736	holo-[acyl-carrier-protein] synthase activity
LDO22_RS07565	COG1072	(Pantothenic acid kinase))
LDO22_RS07570	COG1876	peptidase activity
LDO22_RS07575	COG1970	mechanosensitive ion channel activity
LDO22_RS07580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LDO22_RS07590	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LDO22_RS07590	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LDO22_RS07595	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LDO22_RS07595	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LDO22_RS07600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LDO22_RS07605	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LDO22_RS07640	COG2894	cell division
LDO22_RS07685	COG1192	Involved in chromosome partitioning
LDO22_RS07720	COG0101	tRNA pseudouridine synthase activity
LDO22_RS07725	COG0203	ribosomal protein L17
LDO22_RS07730	COG0202	RNA polymerase activity
LDO22_RS07735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LDO22_RS07740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LDO22_RS07745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LDO22_RS07750	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LDO22_RS07755	COG3191	aminopeptidase activity
LDO22_RS07780	COG0563	adenylate kinase activity
LDO22_RS07790	COG0200	Binds to the 23S rRNA
LDO22_RS07795	COG1841	ribosomal large subunit assembly
LDO22_RS07800	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LDO22_RS07805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LDO22_RS07810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LDO22_RS07815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LDO22_RS07820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LDO22_RS07825	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LDO22_RS07830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LDO22_RS07835	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LDO22_RS07845	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LDO22_RS07850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LDO22_RS07855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LDO22_RS07860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LDO22_RS07865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LDO22_RS07870	COG0089	rRNA binding
LDO22_RS07875	COG0088	Forms part of the polypeptide exit tunnel
LDO22_RS07880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LDO22_RS07885	COG0051	transcription antitermination factor activity, RNA binding
LDO22_RS07900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LDO22_RS07905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LDO22_RS07910	COG0049	tRNA binding
LDO22_RS07915	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LDO22_RS07920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LDO22_RS07925	COG0085	RNA polymerase activity
LDO22_RS07935	COG0183	Belongs to the thiolase family
LDO22_RS07940	COG0442	prolyl-tRNA aminoacylation
LDO22_RS07945	COG0222	ribosome binding
LDO22_RS07950	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LDO22_RS07965	COG0081	regulation of translation
LDO22_RS07970	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LDO22_RS07990	COG0436	Aminotransferase
LDO22_RS07995	COG2197	response regulator
LDO22_RS08050	COG3485	protocatechuate 3,4-dioxygenase
LDO22_RS08060	COG0745	RESPONSE REGULATOR receiver
LDO22_RS08065	COG0456	acetyltransferase
LDO22_RS08070	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LDO22_RS08085	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LDO22_RS08090	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LDO22_RS08115	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LDO22_RS08130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LDO22_RS08135	COG0738	Major facilitator superfamily
LDO22_RS08145	COG2030	dehydratase
LDO22_RS08155	COG0659	secondary active sulfate transmembrane transporter activity
LDO22_RS08175	COG4989	oxidoreductase activity
LDO22_RS08180	COG0366	Alpha amylase catalytic
LDO22_RS08185	COG1940	carbohydrate kinase activity
LDO22_RS08195	COG0702	epimerase
LDO22_RS08220	COG0706	membrane insertase activity
LDO22_RS08250	COG0754	glutathionylspermidine amidase activity
LDO22_RS08265	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS08290	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LDO22_RS08325	COG0318	PFAM AMP-dependent synthetase and ligase
LDO22_RS08335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDO22_RS08345	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LDO22_RS08370	COG1666	GTP binding
LDO22_RS08385	COG2837	iron assimilation
LDO22_RS08390	COG0501	Belongs to the peptidase M48B family
LDO22_RS08415	COG0531	amino acid
LDO22_RS08480	COG1215	transferase activity, transferring glycosyl groups
LDO22_RS08495	COG1012	belongs to the aldehyde dehydrogenase family
LDO22_RS08500	COG3835	regulator
LDO22_RS08515	COG2186	Transcriptional regulator
LDO22_RS08545	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LDO22_RS08545	COG1648	precorrin-2 dehydrogenase activity
LDO22_RS08560	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LDO22_RS08570	COG1690	Belongs to the RtcB family
LDO22_RS08585	COG2895	sulfate adenylyltransferase (ATP) activity
LDO22_RS08595	COG0175	sulfate reduction
LDO22_RS08600	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LDO22_RS08610	COG2860	membrane
LDO22_RS08625	COG0142	geranyltranstransferase activity
LDO22_RS08635	COG2226	methyltransferase
LDO22_RS08640	COG1169	isochorismate synthase
LDO22_RS08650	COG0765	amino acid transport
LDO22_RS08655	COG1126	abc transporter atp-binding protein
LDO22_RS08660	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LDO22_RS08665	COG1609	Transcriptional regulator
LDO22_RS08670	COG1621	beta-fructofuranosidase activity
LDO22_RS08675	COG0395	ABC-type sugar transport system, permease component
LDO22_RS08680	COG1175	transmembrane transport
LDO22_RS08700	COG4948	Mandelate Racemase Muconate Lactonizing
LDO22_RS08705	COG0598	Magnesium transport protein CorA
LDO22_RS08715	COG3559	Exporter of polyketide antibiotics
LDO22_RS08720	COG1131	(ABC) transporter
LDO22_RS08785	COG1309	transcriptional regulator
LDO22_RS08800	COG2072	flavoprotein involved in K transport
LDO22_RS08835	COG0492	ferredoxin-NADP+ reductase activity
LDO22_RS08850	COG1846	Transcriptional regulator
LDO22_RS08875	COG1316	TRANSCRIPTIONal
LDO22_RS08890	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LDO22_RS08890	COG2755	lipolytic protein G-D-S-L family
LDO22_RS08900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDO22_RS08905	COG3795	YCII-related domain
LDO22_RS08910	COG4941	Belongs to the sigma-70 factor family
LDO22_RS08915	COG1215	transferase activity, transferring glycosyl groups
LDO22_RS08925	COG2188	Transcriptional regulator
LDO22_RS08935	COG1597	lipid kinase activity
LDO22_RS08940	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO22_RS08945	COG0022	dehydrogenase e1 component
LDO22_RS08995	COG0438	transferase activity, transferring glycosyl groups
LDO22_RS09005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LDO22_RS09040	COG0745	RESPONSE REGULATOR receiver
LDO22_RS09090	COG0076	glutamate decarboxylase activity
LDO22_RS09095	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LDO22_RS09115	COG1304	FMN binding
LDO22_RS09150	COG0110	maltose O-acetyltransferase activity
LDO22_RS09160	COG0489	protein tyrosine kinase activity
LDO22_RS09195	COG0438	transferase activity, transferring glycosyl groups
LDO22_RS09210	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LDO22_RS09215	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LDO22_RS09235	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LDO22_RS09245	COG0489	protein tyrosine kinase activity
LDO22_RS09265	COG1024	Enoyl-CoA hydratase
LDO22_RS09270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDO22_RS09275	COG2151	metal-sulfur cluster biosynthetic enzyme
LDO22_RS09280	COG3396	Phenylacetate-CoA oxygenase
LDO22_RS09285	COG3460	Phenylacetate-CoA oxygenase
LDO22_RS09290	COG3396	Phenylacetate-CoA oxygenase
LDO22_RS09300	COG0671	phosphoesterase, PA-phosphatase related
LDO22_RS09315	COG5002	protein histidine kinase activity
LDO22_RS09325	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LDO22_RS09350	COG0156	8-amino-7-oxononanoate synthase activity
LDO22_RS09365	COG3604	Transcriptional regulator
LDO22_RS09375	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LDO22_RS09405	COG0667	Aldo Keto reductase
LDO22_RS09415	COG0300	oxidoreductase activity
LDO22_RS09445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDO22_RS09455	COG0640	Transcriptional regulator
LDO22_RS09470	COG1247	-acetyltransferase
LDO22_RS09485	COG0390	transport system, permease component
LDO22_RS09490	COG2353	YceI-like domain
LDO22_RS09505	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LDO22_RS09510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LDO22_RS09530	COG1937	Protein conserved in bacteria
LDO22_RS09535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LDO22_RS09550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LDO22_RS09585	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO22_RS09595	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LDO22_RS09600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDO22_RS09630	COG0277	FAD linked oxidase domain protein
LDO22_RS09635	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LDO22_RS09655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LDO22_RS09660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LDO22_RS09675	COG3842	ATPase activity
LDO22_RS09685	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LDO22_RS09700	COG2217	Heavy metal translocating P-type atpase
LDO22_RS09715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDO22_RS09720	COG1316	TRANSCRIPTIONal
LDO22_RS09730	COG0406	alpha-ribazole phosphatase activity
LDO22_RS09735	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LDO22_RS09740	COG0071	Belongs to the small heat shock protein (HSP20) family
LDO22_RS09780	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LDO22_RS09805	COG4948	Mandelate Racemase Muconate Lactonizing
LDO22_RS09810	COG1802	Transcriptional regulator
LDO22_RS09815	COG2271	Major facilitator Superfamily
LDO22_RS09820	COG0857	belongs to the CobB CobQ family
LDO22_RS09820	COG0280	phosphate acetyltransferase
LDO22_RS09825	COG2050	protein possibly involved in aromatic compounds catabolism
LDO22_RS09840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LDO22_RS09855	COG1012	belongs to the aldehyde dehydrogenase family
LDO22_RS09855	COG2030	dehydratase
LDO22_RS09860	COG2050	protein possibly involved in aromatic compounds catabolism
LDO22_RS09895	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDO22_RS09900	COG1024	Enoyl-CoA hydratase
LDO22_RS09935	COG1266	CAAX protease self-immunity
LDO22_RS09945	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LDO22_RS09995	COG0443	Heat shock 70 kDa protein
LDO22_RS10000	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LDO22_RS10010	COG0785	Cytochrome C biogenesis protein
LDO22_RS10015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDO22_RS10020	COG0406	alpha-ribazole phosphatase activity
LDO22_RS10025	COG2353	YceI-like domain
LDO22_RS10035	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LDO22_RS10060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LDO22_RS10065	COG3458	cephalosporin-C deacetylase activity
LDO22_RS10070	COG1070	Carbohydrate kinase
LDO22_RS10075	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS10075	COG3347	Dehydrogenase
LDO22_RS10080	COG4952	isomerase
LDO22_RS10090	COG1609	Transcriptional regulator
LDO22_RS10115	COG0395	ABC-type sugar transport system, permease component
LDO22_RS10120	COG4209	transmembrane transport
LDO22_RS10125	COG1653	transport
LDO22_RS10130	COG5578	integral membrane protein
LDO22_RS10140	COG2814	Major facilitator Superfamily
LDO22_RS10150	COG0395	ABC-type sugar transport system, permease component
LDO22_RS10155	COG1175	transmembrane transport
LDO22_RS10180	COG0395	ABC-type sugar transport system, permease component
LDO22_RS10185	COG1175	transmembrane transport
LDO22_RS10200	COG0673	inositol 2-dehydrogenase activity
LDO22_RS10215	COG4948	Mandelate Racemase Muconate Lactonizing
LDO22_RS10220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDO22_RS10225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDO22_RS10230	COG0673	inositol 2-dehydrogenase activity
LDO22_RS10245	COG2190	(PTS) system
LDO22_RS10245	COG2211	Major facilitator Superfamily
LDO22_RS10255	COG2186	Transcriptional regulator
LDO22_RS10265	COG0640	Transcriptional regulator
LDO22_RS10270	COG0123	including yeast histone deacetylase and acetoin utilization protein
LDO22_RS10275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LDO22_RS10280	COG0569	domain protein
LDO22_RS10285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LDO22_RS10290	COG0248	Ppx GppA phosphatase
LDO22_RS10300	COG1754	DNA topoisomerase type I activity
LDO22_RS10300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LDO22_RS10305	COG2890	protein-(glutamine-N5) methyltransferase activity
LDO22_RS10320	COG1054	Belongs to the UPF0176 family
LDO22_RS10330	COG1205	dead DEAH box helicase
LDO22_RS10330	COG1111	helicase
LDO22_RS10385	COG0494	nUDIX hydrolase
LDO22_RS10400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDO22_RS10405	COG1349	DNA-binding transcription factor activity
LDO22_RS10410	COG1609	Transcriptional regulator
LDO22_RS10420	COG4209	transmembrane transport
LDO22_RS10425	COG0395	ABC-type sugar transport system, permease component
LDO22_RS10440	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LDO22_RS10460	COG0395	ABC-type sugar transport system, permease component
LDO22_RS10465	COG1175	transmembrane transport
LDO22_RS10475	COG1609	Transcriptional regulator
LDO22_RS10495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LDO22_RS10500	COG1408	metallophosphoesterase
LDO22_RS10505	COG1132	(ABC) transporter
LDO22_RS10510	COG1132	(ABC) transporter
LDO22_RS10530	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LDO22_RS10535	COG0151	Belongs to the GarS family
LDO22_RS10570	COG1953	Uracil, thiamine, allantoin
LDO22_RS10575	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LDO22_RS10595	COG0667	Aldo Keto reductase
LDO22_RS10600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LDO22_RS10610	COG3608	succinylglutamate desuccinylase aspartoacylase
LDO22_RS10610	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LDO22_RS10615	COG2252	PERMEase
LDO22_RS10620	COG0590	tRNA wobble adenosine to inosine editing
LDO22_RS10630	COG1793	dna ligase
LDO22_RS10630	COG3285	dna ligase
LDO22_RS10650	COG2233	PERMEase
LDO22_RS10655	COG1414	Transcriptional regulator
LDO22_RS10665	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LDO22_RS10675	COG3257	ureidoglycine aminohydrolase activity
LDO22_RS10690	COG0546	phosphoglycolate phosphatase activity
LDO22_RS10700	COG3387	PFAM Glycoside hydrolase 15-related
LDO22_RS10725	COG0484	heat shock protein binding
LDO22_RS10730	COG0071	Belongs to the small heat shock protein (HSP20) family
LDO22_RS10735	COG0789	Transcriptional regulator
LDO22_RS10750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDO22_RS10755	COG0563	adenylate kinase activity
LDO22_RS10765	COG0745	RESPONSE REGULATOR receiver
LDO22_RS10770	COG2267	carboxylic ester hydrolase activity
LDO22_RS10775	COG0640	Transcriptional regulator
LDO22_RS10795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO22_RS10805	COG0579	oxidoreductase
LDO22_RS10845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LDO22_RS10845	COG4499	WXG100 protein secretion system (Wss), protein YukC
LDO22_RS10940	COG2070	2-Nitropropane dioxygenase
LDO22_RS10945	COG1064	alcohol dehydrogenase
LDO22_RS10950	COG1063	alcohol dehydrogenase
LDO22_RS10965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDO22_RS10970	COG1116	anion transmembrane transporter activity
LDO22_RS10975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO22_RS11005	COG0129	dihydroxy-acid dehydratase activity
LDO22_RS11030	COG2508	Transcriptional regulator
LDO22_RS11050	COG0477	Major facilitator Superfamily
LDO22_RS11060	COG1012	belongs to the aldehyde dehydrogenase family
LDO22_RS11065	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS11075	COG1024	Enoyl-CoA hydratase
LDO22_RS11080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO22_RS11090	COG0477	Major facilitator Superfamily
LDO22_RS11095	COG1396	sequence-specific DNA binding
LDO22_RS11130	COG0640	Transcriptional regulator
LDO22_RS11145	COG2199	diguanylate cyclase activity
LDO22_RS11145	COG2200	EAL domain
LDO22_RS11145	COG2202	Pas domain
LDO22_RS11175	COG0454	-acetyltransferase
LDO22_RS11185	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LDO22_RS11190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LDO22_RS11220	COG1960	acyl-CoA dehydrogenase activity
LDO22_RS11225	COG0583	DNA-binding transcription factor activity
LDO22_RS11230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO22_RS11240	COG1960	acyl-CoA dehydrogenase activity
LDO22_RS11260	COG0477	Major facilitator Superfamily
LDO22_RS11275	COG2807	transmembrane transport
LDO22_RS11285	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LDO22_RS11290	COG4251	negative regulation of phosphorylation
LDO22_RS11300	COG2329	Antibiotic biosynthesis monooxygenase
LDO22_RS11310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDO22_RS11315	COG2197	response regulator
LDO22_RS11320	COG4585	Histidine kinase
LDO22_RS11330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LDO22_RS11365	COG3401	FG-GAP repeat protein
LDO22_RS11400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LDO22_RS11465	COG1473	amidohydrolase
LDO22_RS11470	COG0477	Major facilitator Superfamily
LDO22_RS11480	COG3622	Belongs to the hyi family
LDO22_RS11485	COG2084	Dehydrogenase
LDO22_RS11490	COG3960	tartronate-semialdehyde synthase activity
LDO22_RS11495	COG1929	Belongs to the glycerate kinase type-1 family
LDO22_RS11500	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LDO22_RS11535	COG0745	RESPONSE REGULATOR receiver
LDO22_RS11545	COG1366	Belongs to the anti-sigma-factor antagonist family
LDO22_RS11560	COG2351	hydroxyisourate hydrolase activity
LDO22_RS11565	COG1414	Transcriptional regulator
LDO22_RS11570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LDO22_RS11580	COG1802	Transcriptional regulator
LDO22_RS11595	COG3404	Formiminotransferase-cyclodeaminase
LDO22_RS11600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LDO22_RS11610	COG2271	Major facilitator Superfamily
LDO22_RS11635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDO22_RS11655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LDO22_RS11665	COG2267	carboxylic ester hydrolase activity
LDO22_RS11700	COG3585	molybdate ion transport
LDO22_RS11715	COG3304	Inner membrane component domain
LDO22_RS11720	COG0135	phosphoribosylanthranilate isomerase activity
LDO22_RS11735	COG2076	Multidrug Resistance protein
LDO22_RS11745	COG0667	Aldo Keto reductase
LDO22_RS11775	COG2807	transmembrane transport
LDO22_RS11785	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LDO22_RS11850	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LDO22_RS11870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDO22_RS11880	COG0069	glutamate synthase activity
LDO22_RS11885	COG2218	PFAM glutamate synthase alpha subunit domain protein
LDO22_RS11890	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LDO22_RS11905	COG0673	inositol 2-dehydrogenase activity
LDO22_RS11935	COG3226	Transcriptional regulator
LDO22_RS11960	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LDO22_RS11985	COG1309	transcriptional regulator
LDO22_RS11990	COG1012	belongs to the aldehyde dehydrogenase family
LDO22_RS11995	COG1115	amino acid carrier protein
LDO22_RS12000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDO22_RS12005	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LDO22_RS12010	COG2271	Major facilitator Superfamily
LDO22_RS12015	COG1802	Transcriptional regulator
LDO22_RS12030	COG1760	l-serine dehydratase
LDO22_RS12055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LDO22_RS12065	COG2801	Transposase and inactivated derivatives
LDO22_RS12065	COG3415	Transposase
LDO22_RS12075	COG1846	Transcriptional regulator
LDO22_RS12075	COG1940	carbohydrate kinase activity
LDO22_RS12085	COG1175	transmembrane transport
LDO22_RS12090	COG0395	ABC-type sugar transport system, permease component
LDO22_RS12105	COG1605	Chorismate mutase
LDO22_RS12105	COG0077	Prephenate dehydratase
LDO22_RS12135	COG3971	2-oxopent-4-enoate hydratase activity
LDO22_RS12150	COG1012	belongs to the aldehyde dehydrogenase family
LDO22_RS12160	COG0789	Transcriptional regulator
LDO22_RS12165	COG0484	heat shock protein binding
LDO22_RS12170	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LDO22_RS12175	COG0443	Heat shock 70 kDa protein
LDO22_RS12180	COG0640	Transcriptional regulator
LDO22_RS12185	COG2814	Major facilitator Superfamily
LDO22_RS12205	COG2409	Drug exporters of the RND superfamily
LDO22_RS12220	COG1280	lysine exporter protein (LysE YggA)
LDO22_RS12225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDO22_RS12240	COG2814	Major facilitator Superfamily
LDO22_RS12245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LDO22_RS12295	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LDO22_RS12300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LDO22_RS12310	COG1122	ATPase activity
LDO22_RS12315	COG4721	ABC-type cobalt transport system, permease component
LDO22_RS12320	COG4702	Belongs to the UPF0303 family
LDO22_RS12340	COG1320	monovalent cation:proton antiporter activity
LDO22_RS12345	COG2212	antiporter activity
LDO22_RS12355	COG0651	ATP synthesis coupled electron transport
LDO22_RS12360	COG1006	Multisubunit Na H antiporter MnhC subunit
LDO22_RS12365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LDO22_RS12365	COG2111	Na H antiporter
LDO22_RS12380	COG0475	glutathione-regulated potassium exporter activity
LDO22_RS12385	COG0717	Belongs to the dCTP deaminase family
LDO22_RS12415	COG0583	DNA-binding transcription factor activity
LDO22_RS12425	COG1012	belongs to the aldehyde dehydrogenase family
LDO22_RS12430	COG0531	amino acid
LDO22_RS12435	COG0583	DNA-binding transcription factor activity
LDO22_RS12440	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LDO22_RS12460	COG2814	Major facilitator Superfamily
LDO22_RS12465	COG3387	PFAM Glycoside hydrolase 15-related
LDO22_RS12470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO22_RS12475	COG0667	Aldo Keto reductase
LDO22_RS12485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDO22_RS12495	COG2814	Major facilitator Superfamily
LDO22_RS12500	COG0583	DNA-binding transcription factor activity
LDO22_RS12530	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LDO22_RS12535	COG4638	Rieske (2fe-2S)
LDO22_RS12540	COG3485	protocatechuate 3,4-dioxygenase
LDO22_RS12560	COG1012	belongs to the aldehyde dehydrogenase family
LDO22_RS12580	COG3845	ABC transporter
LDO22_RS12590	COG3813	Protein conserved in bacteria
LDO22_RS12595	COG1410	methionine synthase
LDO22_RS12595	COG0646	methionine synthase
LDO22_RS12610	COG2267	carboxylic ester hydrolase activity
LDO22_RS12635	COG1802	Transcriptional regulator
LDO22_RS12645	COG3842	ATPase activity
LDO22_RS12655	COG1840	ABC-type Fe3 transport system, periplasmic component
LDO22_RS12665	COG0583	DNA-binding transcription factor activity
LDO22_RS12670	COG2828	Protein conserved in bacteria
LDO22_RS12675	COG1301	dicarboxylic acid transport
LDO22_RS12685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO22_RS12690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO22_RS12705	COG1126	abc transporter atp-binding protein
LDO22_RS12710	COG0765	amino acid transport
LDO22_RS12725	COG0433	COG0433 Predicted ATPase
LDO22_RS12745	COG3336	cytochrome c oxidase
LDO22_RS12750	COG0776	regulation of translation
LDO22_RS12775	COG1609	Transcriptional regulator
LDO22_RS12795	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LDO22_RS12800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LDO22_RS12805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LDO22_RS12810	COG1017	nitric oxide dioxygenase activity
LDO22_RS12810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDO22_RS12850	COG1120	ATPase activity
LDO22_RS12855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDO22_RS12860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDO22_RS12910	COG3012	SEC-C Motif Domain Protein
LDO22_RS12920	COG0667	Aldo Keto reductase
LDO22_RS12960	COG0671	phosphoesterase, PA-phosphatase related
LDO22_RS12965	COG0586	Pfam SNARE associated Golgi protein
LDO22_RS12970	COG2186	Transcriptional regulator
LDO22_RS12980	COG1027	Aspartate ammonia-lyase
LDO22_RS12990	COG0405	Gamma-glutamyltransferase
LDO22_RS12995	COG0039	L-malate dehydrogenase activity
LDO22_RS13000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDO22_RS13015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LDO22_RS13035	COG1522	sequence-specific DNA binding
LDO22_RS13040	COG1280	lysine exporter protein (LysE YggA)
LDO22_RS13065	COG1309	transcriptional regulator
LDO22_RS13080	COG0477	Major facilitator Superfamily
LDO22_RS13085	COG0477	Major facilitator Superfamily
LDO22_RS13090	COG2814	Major facilitator Superfamily
LDO22_RS13105	COG0246	Mannitol dehydrogenase
LDO22_RS13110	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDO22_RS13110	COG2213	PTS system mannitol-specific
LDO22_RS13120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LDO22_RS13130	COG0596	Alpha beta hydrolase
LDO22_RS13140	COG0686	Belongs to the AlaDH PNT family
LDO22_RS13145	COG0673	inositol 2-dehydrogenase activity
LDO22_RS13175	COG0431	NADPH-dependent FMN reductase
LDO22_RS13185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDO22_RS13205	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO22_RS13210	COG0022	dehydrogenase e1 component
LDO22_RS13220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LDO22_RS13245	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LDO22_RS13250	COG0406	alpha-ribazole phosphatase activity
LDO22_RS13255	COG0515	serine threonine protein kinase
LDO22_RS13255	COG2815	serine threonine protein kinase
LDO22_RS13275	COG1607	acyl-coa hydrolase
LDO22_RS13280	COG1840	ABC-type Fe3 transport system, periplasmic component
LDO22_RS13285	COG3842	ATPase activity
LDO22_RS13290	COG1178	ABC-type Fe3 transport system permease component
LDO22_RS13325	COG2271	Major facilitator Superfamily
LDO22_RS13330	COG1802	Transcriptional regulator
LDO22_RS13350	COG1597	lipid kinase activity
LDO22_RS13370	COG2186	Transcriptional regulator
LDO22_RS13375	COG2159	amidohydrolase
LDO22_RS13385	COG1414	Transcriptional regulator
LDO22_RS13390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDO22_RS13395	COG0477	Major facilitator Superfamily
LDO22_RS13400	COG1414	Transcriptional regulator
LDO22_RS13405	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LDO22_RS13415	COG0183	Belongs to the thiolase family
LDO22_RS13420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LDO22_RS13435	COG3485	protocatechuate 3,4-dioxygenase
LDO22_RS13440	COG3485	protocatechuate 3,4-dioxygenase
LDO22_RS13445	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LDO22_RS13445	COG1082	Xylose isomerase domain protein TIM barrel
LDO22_RS13450	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDO22_RS13455	COG1414	Transcriptional regulator
LDO22_RS13460	COG0477	Major facilitator Superfamily
LDO22_RS13465	COG1793	dna ligase
LDO22_RS13490	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LDO22_RS13495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LDO22_RS13510	COG1012	belongs to the aldehyde dehydrogenase family
LDO22_RS13515	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LDO22_RS13525	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LDO22_RS13560	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LDO22_RS13590	COG1937	Protein conserved in bacteria
LDO22_RS13640	COG2259	Doxx family
LDO22_RS13650	COG0305	Participates in initiation and elongation during chromosome replication
LDO22_RS13675	COG0359	binds to the 23S rRNA
LDO22_RS13680	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LDO22_RS13690	COG0360	Binds together with S18 to 16S ribosomal RNA
LDO22_RS13705	COG2244	polysaccharide biosynthetic process
LDO22_RS13715	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LDO22_RS13730	COG1216	Glycosyl transferase, family 2
LDO22_RS13740	COG0463	Glycosyl transferase, family 2
LDO22_RS13755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LDO22_RS13760	COG0673	inositol 2-dehydrogenase activity
LDO22_RS13765	COG1088	dTDP-glucose 4,6-dehydratase activity
LDO22_RS13770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LDO22_RS13825	COG1362	aminopeptidase activity
LDO22_RS13830	COG1113	amino acid transport
LDO22_RS13850	COG0738	Major facilitator superfamily
LDO22_RS13860	COG0488	(ABC) transporter
LDO22_RS13865	COG0768	penicillin binding
LDO22_RS13880	COG0406	alpha-ribazole phosphatase activity
LDO22_RS13885	COG0617	tRNA 3'-terminal CCA addition
LDO22_RS13905	COG0492	ferredoxin-NADP+ reductase activity
LDO22_RS13910	COG3118	belongs to the thioredoxin family
LDO22_RS13920	COG1192	Involved in chromosome partitioning
LDO22_RS13925	COG0357	Ribosomal RNA small subunit methyltransferase G
LDO22_RS13935	COG0706	membrane insertase activity
LDO22_RS13940	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LDO22_RS13945	COG0594	ribonuclease P activity
LDO22_RS13950	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LDO22_RS13955	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LDO22_RS13960	COG0592	DNA-directed DNA polymerase activity
LDO22_RS13970	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LDO22_RS13975	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
LDO22_RS13980	COG0187	DNA topoisomerase II activity
LDO22_RS13985	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LDO22_RS13990	COG3266	domain, Protein
LDO22_RS14035	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LDO22_RS14040	COG2818	Glycosylase
LDO22_RS14050	COG3764	Sortase (surface protein transpeptidase)
LDO22_RS14065	COG0515	serine threonine protein kinase
LDO22_RS14070	COG0515	serine threonine protein kinase
LDO22_RS14090	COG1716	ATPase activity
LDO22_RS14095	COG1716	ATPase activity
LDO22_RS14115	COG2130	NADP-dependent
LDO22_RS14145	COG0346	lactoylglutathione lyase activity
LDO22_RS14190	COG0277	FAD linked oxidase domain protein
LDO22_RS14195	COG0154	amidase activity
LDO22_RS14200	COG2957	Belongs to the agmatine deiminase family
LDO22_RS14210	COG1162	GTPase activity
LDO22_RS14225	COG0477	Major facilitator Superfamily
LDO22_RS14245	COG3706	GGDEF domain
LDO22_RS14265	COG0673	inositol 2-dehydrogenase activity
LDO22_RS14275	COG1175	transmembrane transport
LDO22_RS14280	COG1653	transport
LDO22_RS14290	COG2084	Dehydrogenase
LDO22_RS14295	COG1082	Xylose isomerase domain protein TIM barrel
LDO22_RS14300	COG0149	triose-phosphate isomerase activity
LDO22_RS14305	COG0698	ribose 5-phosphate isomerase
LDO22_RS14310	COG2376	Dihydroxyacetone kinase
LDO22_RS14320	COG2186	Transcriptional regulator
LDO22_RS14325	COG1609	Transcriptional regulator
LDO22_RS14330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDO22_RS14335	COG0765	amino acid transport
LDO22_RS14340	COG1126	abc transporter atp-binding protein
LDO22_RS14345	COG0673	inositol 2-dehydrogenase activity
LDO22_RS14355	COG0659	secondary active sulfate transmembrane transporter activity
LDO22_RS14390	COG2084	Dehydrogenase
LDO22_RS14400	COG0477	Major facilitator Superfamily
LDO22_RS14435	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LDO22_RS14470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LDO22_RS14500	COG2084	Dehydrogenase
LDO22_RS14520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDO22_RS14530	COG0460	homoserine dehydrogenase
LDO22_RS14540	COG1609	Transcriptional regulator
LDO22_RS14545	COG1957	nucleoside hydrolase
LDO22_RS14550	COG0477	Major facilitator Superfamily
LDO22_RS14555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDO22_RS14560	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS14565	COG1940	carbohydrate kinase activity
LDO22_RS14565	COG1846	Transcriptional regulator
LDO22_RS14570	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
LDO22_RS14575	COG3842	ATPase activity
LDO22_RS14585	COG1175	transmembrane transport
LDO22_RS14630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LDO22_RS14645	COG0561	phosphatase activity
LDO22_RS14670	COG2200	EAL domain
LDO22_RS14670	COG2203	Gaf domain
LDO22_RS14670	COG2199	diguanylate cyclase activity
LDO22_RS14680	COG5002	protein histidine kinase activity
LDO22_RS14695	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS14700	COG1929	Belongs to the glycerate kinase type-1 family
LDO22_RS14715	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS14730	COG0823	Involved in the tonB-independent uptake of proteins
LDO22_RS14740	COG0673	inositol 2-dehydrogenase activity
LDO22_RS14745	COG0673	inositol 2-dehydrogenase activity
LDO22_RS14755	COG0395	ABC-type sugar transport system, permease component
LDO22_RS14805	COG2233	PERMEase
LDO22_RS14810	COG0778	Nitroreductase
LDO22_RS14830	COG0583	DNA-binding transcription factor activity
LDO22_RS14845	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LDO22_RS14850	COG2186	Transcriptional regulator
LDO22_RS14860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO22_RS14870	COG5416	Lipopolysaccharide assembly protein A domain
LDO22_RS14885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LDO22_RS14900	COG1597	lipid kinase activity
LDO22_RS14905	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LDO22_RS14915	COG0561	phosphatase activity
LDO22_RS14965	COG0037	tRNA processing
LDO22_RS14975	COG1609	Transcriptional regulator
LDO22_RS14980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDO22_RS14985	COG0302	gtp cyclohydrolase
LDO22_RS14990	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LDO22_RS14995	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LDO22_RS15025	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LDO22_RS15045	COG0693	protein deglycase activity
LDO22_RS15050	COG2814	Major facilitator Superfamily
LDO22_RS15060	COG1309	transcriptional regulator
LDO22_RS15075	COG3665	Urea carboxylase-associated protein
LDO22_RS15095	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LDO22_RS15115	COG0823	Involved in the tonB-independent uptake of proteins
LDO22_RS15115	COG1506	peptidase
LDO22_RS15120	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LDO22_RS15125	COG2376	Dihydroxyacetone kinase
LDO22_RS15130	COG1461	Dihydroxyacetone kinase
LDO22_RS15135	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LDO22_RS15165	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LDO22_RS15180	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LDO22_RS15200	COG5002	protein histidine kinase activity
LDO22_RS15215	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LDO22_RS15230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LDO22_RS15245	COG0306	phosphate transporter
LDO22_RS15265	COG0739	heme binding
LDO22_RS15275	COG1609	Transcriptional regulator
LDO22_RS15290	COG1595	DNA-templated transcription, initiation
LDO22_RS15315	COG1609	Transcriptional regulator
LDO22_RS15320	COG1335	isochorismatase
LDO22_RS15325	COG0831	urea catabolic process
LDO22_RS15330	COG0832	Belongs to the urease beta subunit family
LDO22_RS15335	COG0804	urea catabolic process
LDO22_RS15340	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LDO22_RS15345	COG0830	nickel cation binding
LDO22_RS15350	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LDO22_RS15355	COG0829	nickel cation binding
LDO22_RS15360	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LDO22_RS15385	COG3958	Transketolase
LDO22_RS15390	COG3959	Transketolase, thiamine diphosphate binding domain
LDO22_RS15395	COG0477	Major facilitator Superfamily
LDO22_RS15405	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS15410	COG2376	Dihydroxyacetone kinase
LDO22_RS15415	COG0698	ribose 5-phosphate isomerase
LDO22_RS15425	COG2272	Belongs to the type-B carboxylesterase lipase family
LDO22_RS15440	COG4133	protoheme IX ABC transporter activity
LDO22_RS15470	COG2723	6-phospho-beta-galactosidase activity
LDO22_RS15495	COG3250	beta-galactosidase activity
LDO22_RS15505	COG3507	Belongs to the glycosyl hydrolase 43 family
LDO22_RS15515	COG0583	DNA-binding transcription factor activity
LDO22_RS15525	COG1414	Transcriptional regulator
LDO22_RS15530	COG3250	beta-galactosidase activity
LDO22_RS15555	COG1175	transmembrane transport
LDO22_RS15560	COG0395	ABC-type sugar transport system, permease component
LDO22_RS15565	COG4948	Mandelate Racemase Muconate Lactonizing
LDO22_RS15570	COG0800	Aldolase
LDO22_RS15580	COG4948	Mandelate Racemase Muconate Lactonizing
LDO22_RS15590	COG0477	Major facilitator Superfamily
LDO22_RS15605	COG2226	methyltransferase
LDO22_RS15630	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS15640	COG1960	acyl-CoA dehydrogenase activity
LDO22_RS15650	COG0477	Major facilitator Superfamily
LDO22_RS15660	COG1609	Transcriptional regulator
LDO22_RS15665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDO22_RS15670	COG2271	Major facilitator Superfamily
LDO22_RS15675	COG0385	Bile acid
LDO22_RS15680	COG0243	molybdopterin cofactor binding
LDO22_RS15695	COG0657	acetylesterase activity
LDO22_RS15700	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDO22_RS15705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDO22_RS15735	COG0436	Aminotransferase
LDO22_RS15740	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LDO22_RS15750	COG0583	DNA-binding transcription factor activity
LDO22_RS15755	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LDO22_RS15760	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LDO22_RS15765	COG1984	allophanate hydrolase subunit 2
LDO22_RS15770	COG4221	oxidoreductase activity
LDO22_RS15775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LDO22_RS15780	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS15785	COG1063	alcohol dehydrogenase
LDO22_RS15790	COG3265	gluconokinase activity
LDO22_RS15800	COG0697	spore germination
LDO22_RS15815	COG0667	Aldo Keto reductase
LDO22_RS15840	COG2890	protein-(glutamine-N5) methyltransferase activity
LDO22_RS15845	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LDO22_RS15880	COG0318	PFAM AMP-dependent synthetase and ligase
LDO22_RS15885	COG0183	Belongs to the thiolase family
LDO22_RS15890	COG1960	acyl-CoA dehydrogenase activity
LDO22_RS15895	COG1309	transcriptional regulator
LDO22_RS15905	COG0667	Aldo Keto reductase
LDO22_RS15925	COG3360	Dodecin
LDO22_RS15930	COG2186	Transcriptional regulator
LDO22_RS15940	COG2084	Dehydrogenase
LDO22_RS15945	COG2610	gluconate transmembrane transporter activity
LDO22_RS15975	COG0300	oxidoreductase activity
LDO22_RS15985	COG0477	Major facilitator Superfamily
LDO22_RS15995	COG1793	dna ligase
LDO22_RS15995	COG3285	dna ligase
LDO22_RS16000	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LDO22_RS16020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDO22_RS16020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LDO22_RS16020	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LDO22_RS16025	COG1105	Belongs to the carbohydrate kinase PfkB family
LDO22_RS16045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDO22_RS16055	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LDO22_RS16065	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LDO22_RS16070	COG0509	glycine decarboxylation via glycine cleavage system
LDO22_RS16075	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LDO22_RS16080	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LDO22_RS16080	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LDO22_RS16085	COG1113	amino acid transport
LDO22_RS16115	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LDO22_RS16125	COG2733	membrane
LDO22_RS16135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO22_RS16180	COG4122	O-methyltransferase activity
LDO22_RS16230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDO22_RS16235	COG1191	sigma factor activity
LDO22_RS16240	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LDO22_RS16245	COG0859	PFAM glycosyl transferase family 9
LDO22_RS16255	COG0297	glycogen (starch) synthase activity
LDO22_RS16260	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LDO22_RS16265	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LDO22_RS16265	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LDO22_RS16270	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS16280	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LDO22_RS16280	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LDO22_RS16300	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS16310	COG1733	regulation of RNA biosynthetic process
LDO22_RS16315	COG0702	epimerase
LDO22_RS16320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LDO22_RS16325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDO22_RS16335	COG1414	Transcriptional regulator
LDO22_RS16340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO22_RS16365	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LDO22_RS16385	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDO22_RS16390	COG0589	response to stress
LDO22_RS16410	COG3290	protein histidine kinase activity
LDO22_RS16420	COG0010	Belongs to the arginase family
LDO22_RS16425	COG3263	regulation of cellular component size
LDO22_RS16430	COG2252	PERMEase
LDO22_RS16450	COG3848	Pyruvate phosphate dikinase
LDO22_RS16450	COG0574	Belongs to the PEP-utilizing enzyme family
LDO22_RS16470	COG3883	PFAM NLP P60 protein
LDO22_RS16470	COG0791	NLP P60 protein
LDO22_RS16495	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LDO22_RS16495	COG1796	DNA polymerase
LDO22_RS16545	COG0366	Alpha amylase catalytic
LDO22_RS16570	COG1609	Transcriptional regulator
LDO22_RS16585	COG1024	Enoyl-CoA hydratase
LDO22_RS16605	COG0789	Transcriptional regulator
LDO22_RS16615	COG1278	Cold shock
LDO22_RS16620	COG2197	response regulator
LDO22_RS16625	COG4585	Histidine kinase
LDO22_RS16635	COG0666	response to abiotic stimulus
LDO22_RS16650	COG2031	fatty acid transporter
LDO22_RS16655	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LDO22_RS16665	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LDO22_RS16675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LDO22_RS16700	COG0357	Ribosomal RNA small subunit methyltransferase G
LDO22_RS16700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDO22_RS16705	COG0191	fructose-bisphosphate aldolase activity
LDO22_RS16730	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LDO22_RS16740	COG1595	DNA-templated transcription, initiation
LDO22_RS16750	COG1832	CoA-binding protein
LDO22_RS16770	COG1832	CoA-binding protein
LDO22_RS16780	COG2315	Protein conserved in bacteria
LDO22_RS16805	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LDO22_RS16810	COG0047	phosphoribosylformylglycinamidine synthase activity
LDO22_RS16825	COG1404	Belongs to the peptidase S8 family
LDO22_RS16845	COG1846	Transcriptional regulator
LDO22_RS16865	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LDO22_RS16890	COG0741	lytic transglycosylase activity
LDO22_RS16890	COG1196	nuclear chromosome segregation
LDO22_RS16890	COG0739	heme binding
LDO22_RS16895	COG0386	Belongs to the glutathione peroxidase family
LDO22_RS16900	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LDO22_RS16905	COG0438	transferase activity, transferring glycosyl groups
LDO22_RS16925	COG1309	transcriptional regulator
LDO22_RS16935	COG0438	transferase activity, transferring glycosyl groups
LDO22_RS16950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDO22_RS16960	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LDO22_RS16970	COG1476	TRANSCRIPTIONal
LDO22_RS16980	COG0642	Histidine kinase
LDO22_RS16985	COG0745	RESPONSE REGULATOR receiver
LDO22_RS16990	COG0477	Major facilitator Superfamily
LDO22_RS17000	COG1309	transcriptional regulator
LDO22_RS17005	COG0028	Belongs to the TPP enzyme family
LDO22_RS17010	COG0351	phosphomethylpyrimidine kinase
LDO22_RS17020	COG0343	queuine tRNA-ribosyltransferase activity
LDO22_RS17050	COG1621	beta-fructofuranosidase activity
LDO22_RS17065	COG1960	acyl-CoA dehydrogenase activity
LDO22_RS17080	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LDO22_RS17090	COG0586	Pfam SNARE associated Golgi protein
LDO22_RS17100	COG0564	pseudouridine synthase activity
LDO22_RS17120	COG2364	Membrane
LDO22_RS17125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LDO22_RS17130	COG1201	RNA secondary structure unwinding
LDO22_RS17135	COG0644	oxidoreductase
LDO22_RS17155	COG0028	Belongs to the TPP enzyme family
LDO22_RS17165	COG2066	Belongs to the glutaminase family
LDO22_RS17170	COG2508	Transcriptional regulator
LDO22_RS17170	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LDO22_RS17180	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDO22_RS17195	COG2814	Major facilitator Superfamily
LDO22_RS17200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDO22_RS17220	COG1309	transcriptional regulator
LDO22_RS17255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDO22_RS17260	COG0657	acetylesterase activity
LDO22_RS17265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDO22_RS17275	COG1609	Transcriptional regulator
LDO22_RS17285	COG1175	transmembrane transport
LDO22_RS17290	COG0395	ABC-type sugar transport system, permease component
LDO22_RS17300	COG0673	inositol 2-dehydrogenase activity
LDO22_RS17310	COG1904	glucuronate isomerase
LDO22_RS17315	COG0246	Mannitol dehydrogenase
LDO22_RS17320	COG4948	Mandelate Racemase Muconate Lactonizing
LDO22_RS17375	COG0438	transferase activity, transferring glycosyl groups
LDO22_RS17385	COG0671	phosphoesterase, PA-phosphatase related
LDO22_RS17390	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LDO22_RS17405	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LDO22_RS17410	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LDO22_RS17410	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LDO22_RS17420	COG2205	protein histidine kinase activity
LDO22_RS17425	COG0745	RESPONSE REGULATOR receiver
LDO22_RS17445	COG2062	phosphohistidine phosphatase, SixA
LDO22_RS17450	COG0583	DNA-binding transcription factor activity
LDO22_RS17460	COG1309	transcriptional regulator
LDO22_RS17465	COG1511	domain protein
LDO22_RS17485	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LDO22_RS17490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDO22_RS17490	COG1017	nitric oxide dioxygenase activity
LDO22_RS17505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LDO22_RS17510	COG0514	ATP-dependent DNA helicase (RecQ)
LDO22_RS17530	COG1505	serine-type exopeptidase activity
LDO22_RS17540	COG0737	Belongs to the 5'-nucleotidase family
LDO22_RS17550	COG0604	alcohol dehydrogenase
LDO22_RS17550	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS17550	COG3321	synthase
LDO22_RS17560	COG1136	(ABC) transporter
LDO22_RS17560	COG0577	efflux transmembrane transporter activity
LDO22_RS17570	COG1966	Carbon starvation protein
LDO22_RS17590	COG0656	L-ascorbic acid biosynthetic process
LDO22_RS17610	COG1252	NADH dehydrogenase
LDO22_RS17650	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LDO22_RS17655	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LDO22_RS17675	COG0588	phosphoglycerate mutase activity
LDO22_RS17685	COG5002	protein histidine kinase activity
LDO22_RS17710	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LDO22_RS17715	COG0215	cysteine-tRNA ligase activity
LDO22_RS17745	COG0366	Alpha amylase catalytic
LDO22_RS17755	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LDO22_RS17780	COG1609	Transcriptional regulator
LDO22_RS17785	COG0366	Alpha amylase catalytic
LDO22_RS17790	COG0277	FAD linked oxidase domain protein
LDO22_RS17800	COG3842	ATPase activity
LDO22_RS17840	COG4214	carbohydrate transport
LDO22_RS17845	COG1129	ABC transporter
LDO22_RS17850	COG4213	ABC transporter substrate-binding protein
LDO22_RS17865	COG2160	L-arabinose isomerase activity
LDO22_RS17870	COG1609	Transcriptional regulator
LDO22_RS17895	COG0783	Belongs to the Dps family
LDO22_RS17900	COG0477	Major facilitator Superfamily
LDO22_RS17910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LDO22_RS17910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LDO22_RS17915	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LDO22_RS17925	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
LDO22_RS17950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LDO22_RS17965	COG1278	Cold shock
LDO22_RS17975	COG0459	protein refolding
LDO22_RS17980	COG1653	transport
LDO22_RS17985	COG0328	RNA-DNA hybrid ribonuclease activity
LDO22_RS17995	COG2205	protein histidine kinase activity
LDO22_RS18000	COG0745	RESPONSE REGULATOR receiver
LDO22_RS18020	COG1061	Type III restriction enzyme res subunit
LDO22_RS18035	COG1278	Cold shock
LDO22_RS18055	COG0739	heme binding
LDO22_RS18060	COG3103	Sh3 type 3 domain protein
LDO22_RS18060	COG1388	LysM domain
LDO22_RS18060	COG0791	NLP P60 protein
LDO22_RS18075	COG0746	molybdenum cofactor guanylyltransferase activity
LDO22_RS18090	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LDO22_RS18110	COG0488	(ABC) transporter
LDO22_RS18115	COG1132	(ABC) transporter
LDO22_RS18120	COG0494	nUDIX hydrolase
LDO22_RS18145	COG0483	inositol monophosphate 1-phosphatase activity
LDO22_RS18160	COG0045	succinate-CoA ligase (ADP-forming) activity
LDO22_RS18180	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS18190	COG1082	Xylose isomerase domain protein TIM barrel
LDO22_RS18195	COG2376	Dihydroxyacetone kinase
LDO22_RS18200	COG0698	ribose 5-phosphate isomerase
LDO22_RS18205	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDO22_RS18210	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS18215	COG2271	Major facilitator Superfamily
LDO22_RS18220	COG0149	triose-phosphate isomerase activity
LDO22_RS18230	COG0640	Transcriptional regulator
LDO22_RS18235	COG1942	4-Oxalocrotonate Tautomerase
LDO22_RS18250	COG3962	Belongs to the TPP enzyme family
LDO22_RS18265	COG0673	inositol 2-dehydrogenase activity
LDO22_RS18270	COG1082	Xylose isomerase domain protein TIM barrel
LDO22_RS18275	COG2814	Major facilitator Superfamily
LDO22_RS18285	COG2814	Major facilitator Superfamily
LDO22_RS18290	COG1609	Transcriptional regulator
LDO22_RS18295	COG3718	enzyme involved in inositol metabolism
LDO22_RS18300	COG2188	Transcriptional regulator
LDO22_RS18305	COG2814	Major facilitator Superfamily
LDO22_RS18330	COG1396	sequence-specific DNA binding
LDO22_RS18340	COG0028	Belongs to the TPP enzyme family
LDO22_RS18350	COG0477	Major facilitator Superfamily
LDO22_RS18375	COG1401	restriction endodeoxyribonuclease activity
LDO22_RS18385	COG5002	protein histidine kinase activity
LDO22_RS18390	COG0745	RESPONSE REGULATOR receiver
LDO22_RS18400	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LDO22_RS18400	COG4124	Belongs to the glycosyl hydrolase 26 family
LDO22_RS18430	COG1902	pentaerythritol trinitrate reductase activity
LDO22_RS18440	COG2183	response to ionizing radiation
LDO22_RS18475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDO22_RS18490	COG3583	domain protein
LDO22_RS18495	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LDO22_RS18500	COG3103	Sh3 type 3 domain protein
LDO22_RS18500	COG0366	Alpha amylase catalytic
LDO22_RS18505	COG1254	Belongs to the acylphosphatase family
LDO22_RS18520	COG0477	Major facilitator Superfamily
LDO22_RS18525	COG1063	alcohol dehydrogenase
LDO22_RS18540	COG0246	Mannitol dehydrogenase
LDO22_RS18545	COG0800	Aldolase
LDO22_RS18560	COG0667	Aldo Keto reductase
LDO22_RS18565	COG1063	alcohol dehydrogenase
LDO22_RS18580	COG0477	Major facilitator Superfamily
LDO22_RS18585	COG0412	Dienelactone hydrolase
LDO22_RS18595	COG1253	flavin adenine dinucleotide binding
LDO22_RS18605	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDO22_RS18625	COG4948	Mandelate Racemase Muconate Lactonizing
LDO22_RS18630	COG2186	Transcriptional regulator
LDO22_RS18640	COG1175	transmembrane transport
LDO22_RS18645	COG0395	ABC-type sugar transport system, permease component
LDO22_RS18655	COG0640	Transcriptional regulator
LDO22_RS18690	COG1012	belongs to the aldehyde dehydrogenase family
LDO22_RS18695	COG0395	ABC-type sugar transport system, permease component
LDO22_RS18700	COG1175	transmembrane transport
LDO22_RS18710	COG3684	Belongs to the aldolase LacD family
LDO22_RS18720	COG0673	inositol 2-dehydrogenase activity
LDO22_RS18760	COG0477	Major facilitator Superfamily
LDO22_RS18765	COG1846	Transcriptional regulator
LDO22_RS18810	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LDO22_RS18815	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LDO22_RS18820	COG4770	biotin carboxylase activity
LDO22_RS18870	COG2186	Transcriptional regulator
LDO22_RS18875	COG1620	l-lactate permease
LDO22_RS18880	COG0247	lactate metabolic process
LDO22_RS18885	COG1139	Iron-sulfur cluster binding protein
LDO22_RS18890	COG1556	Lactate utilization protein
LDO22_RS18945	COG1609	Transcriptional regulator
LDO22_RS19005	COG3415	Transposase
LDO22_RS19005	COG2801	Transposase and inactivated derivatives
LDO22_RS19010	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LDO22_RS19050	COG3848	Pyruvate phosphate dikinase
LDO22_RS19050	COG0574	Belongs to the PEP-utilizing enzyme family
LDO22_RS19070	COG3848	Pyruvate phosphate dikinase
LDO22_RS19070	COG0574	Belongs to the PEP-utilizing enzyme family
LDO22_RS19085	COG1984	allophanate hydrolase subunit 2
LDO22_RS19090	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LDO22_RS19095	COG0439	Biotin carboxylase
LDO22_RS19100	COG0511	ligase activity, forming carbon-carbon bonds
LDO22_RS19105	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LDO22_RS19110	COG2508	Transcriptional regulator
LDO22_RS19120	COG0252	asparaginase activity
LDO22_RS19135	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS19140	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS19165	COG0484	heat shock protein binding
LDO22_RS19175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LDO22_RS19180	COG0531	amino acid
LDO22_RS19185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LDO22_RS19210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LDO22_RS19220	COG1201	RNA secondary structure unwinding
LDO22_RS19225	COG0210	DNA helicase
LDO22_RS19245	COG1609	Transcriptional regulator
LDO22_RS19265	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDO22_RS19270	COG0673	inositol 2-dehydrogenase activity
LDO22_RS19295	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LDO22_RS19310	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS19315	COG1053	succinate dehydrogenase
LDO22_RS19320	COG1063	alcohol dehydrogenase
LDO22_RS19330	COG0583	DNA-binding transcription factor activity
LDO22_RS19335	COG0583	DNA-binding transcription factor activity
LDO22_RS19340	COG0477	Major facilitator Superfamily
LDO22_RS19345	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDO22_RS19350	COG0673	inositol 2-dehydrogenase activity
LDO22_RS19370	COG1053	succinate dehydrogenase
LDO22_RS19380	COG2350	Protein conserved in bacteria
LDO22_RS19385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDO22_RS19390	COG0477	Major facilitator Superfamily
LDO22_RS19405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDO22_RS19410	COG1349	DNA-binding transcription factor activity
LDO22_RS19415	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LDO22_RS19420	COG3395	kinase activity
LDO22_RS19435	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LDO22_RS19440	COG2814	Major facilitator Superfamily
LDO22_RS19465	COG3540	Alkaline phosphatase
LDO22_RS19485	COG2072	flavoprotein involved in K transport
LDO22_RS19490	COG1063	alcohol dehydrogenase
LDO22_RS19565	COG1914	H( )-stimulated, divalent metal cation uptake system
LDO22_RS19580	COG1278	Cold shock
LDO22_RS19595	COG3265	gluconokinase activity
LDO22_RS19600	COG2610	gluconate transmembrane transporter activity
LDO22_RS19630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDO22_RS19650	COG0833	amino acid
LDO22_RS19660	COG1414	Transcriptional regulator
LDO22_RS19665	COG2040	homocysteine
LDO22_RS19685	COG3300	MHYT domain
LDO22_RS19685	COG5001	Diguanylate cyclase
LDO22_RS19695	COG0561	phosphatase activity
LDO22_RS19700	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LDO22_RS19705	COG0438	transferase activity, transferring glycosyl groups
LDO22_RS19705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LDO22_RS19710	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
LDO22_RS19735	COG0477	Major facilitator Superfamily
LDO22_RS19740	COG0138	bifunctional purine biosynthesis protein purh
LDO22_RS19755	COG2838	Isocitrate dehydrogenase
LDO22_RS19765	COG0515	serine threonine protein kinase
LDO22_RS19785	COG1136	(ABC) transporter
LDO22_RS19795	COG4213	ABC transporter substrate-binding protein
LDO22_RS19800	COG4214	carbohydrate transport
LDO22_RS19825	COG0531	amino acid
LDO22_RS19845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LDO22_RS19850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LDO22_RS19855	COG4585	Histidine kinase
LDO22_RS19860	COG2197	response regulator
LDO22_RS19875	COG0708	Exodeoxyribonuclease III
LDO22_RS19880	COG0180	Tryptophanyl-tRNA synthetase
LDO22_RS19910	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LDO22_RS19925	COG2009	succinate dehydrogenase
LDO22_RS19935	COG1473	amidohydrolase
LDO22_RS19935	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LDO22_RS19940	COG1846	Transcriptional regulator
LDO22_RS19945	COG1764	response to oxidative stress
LDO22_RS19950	COG2130	NADP-dependent
LDO22_RS19955	COG1744	ABC transporter substrate-binding protein PnrA-like
LDO22_RS19960	COG3845	ABC transporter
LDO22_RS19965	COG4603	Belongs to the binding-protein-dependent transport system permease family
LDO22_RS19970	COG1079	Belongs to the binding-protein-dependent transport system permease family
LDO22_RS19985	COG0586	Pfam SNARE associated Golgi protein
LDO22_RS19990	COG0586	Pfam SNARE associated Golgi protein
LDO22_RS19995	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LDO22_RS20000	COG3956	TIGRFAM MazG family protein
LDO22_RS20005	COG0148	phosphopyruvate hydratase activity
LDO22_RS20030	COG1252	NADH dehydrogenase
LDO22_RS20070	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LDO22_RS20080	COG2017	converts alpha-aldose to the beta-anomer
LDO22_RS20090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LDO22_RS20100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LDO22_RS20110	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LDO22_RS20125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LDO22_RS20130	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LDO22_RS20165	COG0114	fumarate hydratase activity
LDO22_RS20170	COG0288	reversible hydration of carbon dioxide
LDO22_RS20180	COG1494	fructose-1,6-bisphosphatase
LDO22_RS20190	COG1482	cell wall glycoprotein biosynthetic process
LDO22_RS20195	COG1316	TRANSCRIPTIONal
LDO22_RS20205	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LDO22_RS20250	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LDO22_RS20305	COG0714	Associated with various cellular activities
LDO22_RS20310	COG0084	hydrolase, TatD family'
LDO22_RS20315	COG3583	domain protein
LDO22_RS20320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LDO22_RS20325	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LDO22_RS20330	COG0488	(ABC) transporter
LDO22_RS20335	COG1309	transcriptional regulator
LDO22_RS20345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LDO22_RS20355	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LDO22_RS20360	COG0193	aminoacyl-tRNA hydrolase activity
LDO22_RS20380	COG0822	iron-sulfur transferase activity
LDO22_RS20395	COG0702	epimerase
LDO22_RS20415	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LDO22_RS20420	COG0446	pyridine nucleotide-disulphide oxidoreductase
LDO22_RS20435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LDO22_RS20445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LDO22_RS20475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LDO22_RS20480	COG0243	molybdopterin cofactor binding
LDO22_RS20485	COG2223	nitrite transmembrane transporter activity
LDO22_RS20490	COG0477	Major facilitator Superfamily
LDO22_RS20505	COG4770	biotin carboxylase activity
LDO22_RS20510	COG0424	maF-like protein
LDO22_RS20515	COG2409	Drug exporters of the RND superfamily
LDO22_RS20530	COG1823	symporter activity
LDO22_RS20535	COG0671	phosphoesterase, PA-phosphatase related
LDO22_RS20550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LDO22_RS20555	COG1028	Short-chain dehydrogenase reductase Sdr
LDO22_RS20560	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LDO22_RS20560	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LDO22_RS20585	COG0714	Associated with various cellular activities
LDO22_RS20605	COG0631	protein serine/threonine phosphatase activity
LDO22_RS20625	COG1674	ftsk spoiiie
LDO22_RS20635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LDO22_RS20640	COG0483	inositol monophosphate 1-phosphatase activity
LDO22_RS20650	COG0251	oxidation-reduction process
LDO22_RS20655	COG4565	transcriptional regulatory protein
LDO22_RS20665	COG2851	Citrate transporter
LDO22_RS20670	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LDO22_RS20675	COG0154	amidase activity
LDO22_RS20680	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LDO22_RS20690	COG0583	DNA-binding transcription factor activity
LDO22_RS20695	COG1063	alcohol dehydrogenase
LDO22_RS20700	COG0156	8-amino-7-oxononanoate synthase activity
LDO22_RS20710	COG1228	amidohydrolase
LDO22_RS20735	COG2873	o-acetylhomoserine
LDO22_RS20740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LDO22_RS20780	COG0400	carboxylic ester hydrolase activity
LDO22_RS20795	COG0423	glycine-tRNA ligase activity
LDO22_RS20810	COG2267	carboxylic ester hydrolase activity
LDO22_RS20820	COG1017	nitric oxide dioxygenase activity
LDO22_RS20820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDO22_RS20860	COG0358	DNA primase activity
LDO22_RS20885	COG2814	Major facilitator Superfamily
LDO22_RS20915	COG1960	acyl-CoA dehydrogenase activity
LDO22_RS20925	COG0052	Belongs to the universal ribosomal protein uS2 family
LDO22_RS20930	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LDO22_RS20935	COG0528	UMP kinase activity
LDO22_RS20940	COG0233	cytoplasmic translational termination
LDO22_RS20960	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LDO22_RS20970	COG3279	Response regulator of the LytR AlgR family
LDO22_RS20975	COG3275	phosphorelay sensor kinase activity
LDO22_RS20985	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LDO22_RS21005	COG1522	sequence-specific DNA binding
LDO22_RS21015	COG0022	dehydrogenase e1 component
LDO22_RS21020	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO22_RS21030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LDO22_RS21040	COG1960	acyl-CoA dehydrogenase activity
LDO22_RS21070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LDO22_RS21075	COG0750	zinc metalloprotease
LDO22_RS21095	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LDO22_RS21110	COG0442	prolyl-tRNA aminoacylation
LDO22_RS21125	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
LDO22_RS21140	COG0779	Required for maturation of 30S ribosomal subunits
LDO22_RS21145	COG0195	Participates in both transcription termination and antitermination
LDO22_RS21155	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LDO22_RS21160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LDO22_RS21170	COG0590	tRNA wobble adenosine to inosine editing
LDO22_RS21180	COG0436	Aminotransferase
LDO22_RS21185	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LDO22_RS21205	COG3483	tryptophan 2,3-dioxygenase activity
LDO22_RS21215	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LDO22_RS21220	COG1185	polyribonucleotide nucleotidyltransferase activity
LDO22_RS21225	COG0612	Peptidase, M16
LDO22_RS21275	COG0521	Mo-molybdopterin cofactor biosynthetic process
LDO22_RS21285	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LDO22_RS21310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDO22_RS21315	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LDO22_RS21320	COG1674	ftsk spoiiie
LDO22_RS21330	COG1546	Belongs to the CinA family
LDO22_RS21330	COG1058	Belongs to the CinA family
LDO22_RS21335	COG1396	sequence-specific DNA binding
LDO22_RS21350	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LDO22_RS21355	COG2137	regulation of response to DNA damage stimulus
LDO22_RS21360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LDO22_RS21365	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LDO22_RS21370	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LDO22_RS21375	COG2813	Specifically methylates the guanine in position
LDO22_RS21380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LDO22_RS21390	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LDO22_RS21400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LDO22_RS21405	COG0131	Imidazoleglycerol-phosphate dehydratase
LDO22_RS21410	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LDO22_RS21420	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LDO22_RS21440	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LDO22_RS21445	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LDO22_RS21450	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LDO22_RS21465	COG2814	Major facilitator Superfamily
LDO22_RS21470	COG0494	nUDIX hydrolase
LDO22_RS21490	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LDO22_RS21495	COG0072	phenylalanine-tRNA ligase activity
LDO22_RS21495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDO22_RS21520	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LDO22_RS21525	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LDO22_RS21530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LDO22_RS21535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LDO22_RS21540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LDO22_RS21545	COG1438	arginine binding
LDO22_RS21550	COG0137	argininosuccinate synthase activity
LDO22_RS21555	COG0165	Argininosuccinate lyase
LDO22_RS21560	COG0259	pyridoxamine-phosphate oxidase activity
LDO22_RS21580	COG2094	Belongs to the DNA glycosylase MPG family
LDO22_RS21585	COG3973	AAA domain
LDO22_RS21590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LDO22_RS21615	COG0647	UMP catabolic process
LDO22_RS21630	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LDO22_RS21635	COG0497	DNA recombination
LDO22_RS21640	COG0504	CTP synthase activity
LDO22_RS21645	COG0494	nUDIX hydrolase
LDO22_RS21670	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LDO22_RS21675	COG2079	MmgE PrpD family protein
LDO22_RS21695	COG3290	protein histidine kinase activity
LDO22_RS21710	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LDO22_RS21715	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LDO22_RS21730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LDO22_RS21750	COG2268	Band 7 protein