locus-tag	class	description
art_RS00040	COG0647	UMP catabolic process
art_RS00055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
art_RS00060	COG0497	DNA recombination
art_RS00065	COG0504	CTP synthase activity
art_RS00070	COG0494	nUDIX hydrolase
art_RS00090	COG0251	oxidation-reduction process
art_RS00095	COG1414	Transcriptional regulator
art_RS00110	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
art_RS00135	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
art_RS00140	COG2079	MmgE PrpD family protein
art_RS00155	COG1280	lysine exporter protein (LysE YggA)
art_RS00165	COG0488	(ABC) transporter
art_RS00195	COG1619	proteins homologs of microcin C7 resistance protein MccF
art_RS00220	COG3290	protein histidine kinase activity
art_RS00225	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
art_RS00230	COG0277	FAD linked oxidase domain protein
art_RS00235	COG0673	inositol 2-dehydrogenase activity
art_RS00245	COG0673	inositol 2-dehydrogenase activity
art_RS00255	COG1175	transmembrane transport
art_RS00285	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
art_RS00290	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
art_RS00305	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
art_RS00315	COG1160	GTP binding
art_RS00340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
art_RS00380	COG1960	acyl-CoA dehydrogenase activity
art_RS00400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
art_RS00405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
art_RS00420	COG0509	glycine decarboxylation via glycine cleavage system
art_RS00425	COG1716	ATPase activity
art_RS00450	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
art_RS00450	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
art_RS00455	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
art_RS00465	COG1940	carbohydrate kinase activity
art_RS00485	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
art_RS00490	COG2815	serine threonine protein kinase
art_RS00490	COG0515	serine threonine protein kinase
art_RS00495	COG1388	LysM domain
art_RS00495	COG3942	CHAP domain
art_RS00505	COG0142	geranyltranstransferase activity
art_RS00510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
art_RS00520	COG2001	Belongs to the MraZ family
art_RS00525	COG0275	rRNA processing
art_RS00535	COG0768	penicillin binding
art_RS00550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
art_RS00555	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
art_RS00565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
art_RS00570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
art_RS00580	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
art_RS00585	COG1496	oxidoreductase activity
art_RS00590	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
art_RS00595	COG1799	cell septum assembly
art_RS00605	COG3599	regulation of cell shape
art_RS00610	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
art_RS00620	COG0587	DNA-directed DNA polymerase activity
art_RS00630	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
art_RS00635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
art_RS00640	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS00655	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
art_RS00660	COG0174	glutamine synthetase
art_RS00665	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
art_RS00675	COG0765	amino acid transport
art_RS00680	COG1126	abc transporter atp-binding protein
art_RS00685	COG2066	Belongs to the glutaminase family
art_RS00965	COG4974	Belongs to the 'phage' integrase family
art_RS00985	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
art_RS00990	COG0321	lipoyl(octanoyl) transferase activity
art_RS01015	COG0508	dehydrogenase complex catalyzes the overall conversion of
art_RS01020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
art_RS01025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
art_RS01030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
art_RS01045	COG2318	DinB family
art_RS01055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
art_RS01060	COG2197	response regulator
art_RS01075	COG0187	DNA topoisomerase II activity
art_RS01080	COG0501	Belongs to the peptidase M48B family
art_RS01090	COG1271	oxidase subunit
art_RS01095	COG1294	oxidase, subunit
art_RS01100	COG4988	ABC transporter
art_RS01115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
art_RS01150	COG0756	dUTP diphosphatase activity
art_RS01175	COG0569	domain protein
art_RS01180	COG0531	amino acid
art_RS01185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
art_RS01195	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
art_RS01215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
art_RS01230	COG0667	Aldo Keto reductase
art_RS01240	COG1024	Enoyl-CoA hydratase
art_RS01240	COG1250	3-hydroxyacyl-CoA dehydrogenase
art_RS01245	COG0183	Belongs to the thiolase family
art_RS01250	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
art_RS01280	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
art_RS01295	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
art_RS01310	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
art_RS01360	COG0242	peptide deformylase activity
art_RS01365	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
art_RS01375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
art_RS01400	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
art_RS01405	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
art_RS01410	COG0140	phosphoribosyl-ATP diphosphatase activity
art_RS01415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
art_RS01420	COG0107	imidazoleglycerol-phosphate synthase activity
art_RS01430	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
art_RS01450	COG0134	indole-3-glycerol-phosphate synthase activity
art_RS01455	COG0133	tryptophan synthase activity
art_RS01460	COG0159	tryptophan synthase activity
art_RS01465	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
art_RS01470	COG0070	glutamate synthase
art_RS01470	COG0067	glutamate synthase
art_RS01470	COG0069	glutamate synthase activity
art_RS01485	COG2826	transposase and inactivated derivatives, IS30 family
art_RS01525	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS01545	COG0783	Belongs to the Dps family
art_RS01605	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
art_RS01615	COG3959	Transketolase, thiamine diphosphate binding domain
art_RS01620	COG0508	dehydrogenase complex catalyzes the overall conversion of
art_RS01625	COG0022	dehydrogenase e1 component
art_RS01630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
art_RS01635	COG3620	sequence-specific DNA binding
art_RS01635	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
art_RS01635	COG0617	tRNA 3'-terminal CCA addition
art_RS01640	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
art_RS01645	COG1053	succinate dehydrogenase
art_RS01685	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
art_RS01690	COG0589	response to stress
art_RS01780	COG1309	transcriptional regulator
art_RS01785	COG0604	alcohol dehydrogenase
art_RS01795	COG0300	oxidoreductase activity
art_RS01815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
art_RS01830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
art_RS01840	COG0019	diaminopimelate decarboxylase activity
art_RS01890	COG0783	Belongs to the Dps family
art_RS01925	COG0300	oxidoreductase activity
art_RS01930	COG2072	flavoprotein involved in K transport
art_RS01940	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
art_RS01945	COG1854	S-ribosylhomocysteine lyase activity
art_RS01955	COG0387	Pfam Sodium calcium exchanger
art_RS01965	COG0454	-acetyltransferase
art_RS02040	COG1309	transcriptional regulator
art_RS02055	COG0488	(ABC) transporter
art_RS02060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
art_RS02075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
art_RS02080	COG0667	Aldo Keto reductase
art_RS02120	COG1053	succinate dehydrogenase
art_RS02135	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
art_RS02160	COG0318	PFAM AMP-dependent synthetase and ligase
art_RS02175	COG1136	(ABC) transporter
art_RS02175	COG0577	efflux transmembrane transporter activity
art_RS02180	COG4585	Histidine kinase
art_RS02185	COG2197	response regulator
art_RS02205	COG2197	response regulator
art_RS02250	COG1132	(ABC) transporter
art_RS02255	COG1132	(ABC) transporter
art_RS02325	COG1902	pentaerythritol trinitrate reductase activity
art_RS02355	COG1472	Belongs to the glycosyl hydrolase 3 family
art_RS02390	COG2130	NADP-dependent
art_RS02400	COG0832	Belongs to the urease beta subunit family
art_RS02405	COG0804	urea catabolic process
art_RS02410	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
art_RS02415	COG0830	nickel cation binding
art_RS02420	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
art_RS02425	COG0829	nickel cation binding
art_RS02430	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
art_RS02450	COG1902	pentaerythritol trinitrate reductase activity
art_RS02460	COG0833	amino acid
art_RS02465	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
art_RS02480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
art_RS02485	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
art_RS02510	COG4213	ABC transporter substrate-binding protein
art_RS02520	COG4214	carbohydrate transport
art_RS02525	COG3142	Participates in the control of copper homeostasis
art_RS02545	COG1162	GTPase activity
art_RS02600	COG2197	response regulator
art_RS02610	COG3153	acetyltransferase
art_RS02620	COG2814	Major facilitator Superfamily
art_RS02625	COG4762	Protein conserved in bacteria
art_RS02650	COG4106	trans-aconitate 2-methyltransferase activity
art_RS02665	COG1725	Transcriptional regulator
art_RS02680	COG1335	isochorismatase
art_RS02770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
art_RS02815	COG0583	DNA-binding transcription factor activity
art_RS02865	COG2197	response regulator
art_RS02870	COG2367	Beta-lactamase
art_RS02900	COG0542	response to heat
art_RS02955	COG4115	mRNA cleavage
art_RS02960	COG2161	toxin-antitoxin pair type II binding
art_RS02965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
art_RS02995	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
art_RS03005	COG0242	peptide deformylase activity
art_RS03010	COG2226	methyltransferase
art_RS03015	COG2364	Membrane
art_RS03040	COG1216	Glycosyl transferase, family 2
art_RS03045	COG1574	metal-dependent hydrolase with the TIM-barrel fold
art_RS03050	COG4581	dead DEAH box helicase
art_RS03055	COG0805	protein transport
art_RS03060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
art_RS03085	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
art_RS03090	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
art_RS03095	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
art_RS03105	COG4122	O-methyltransferase activity
art_RS03110	COG1222	aaa ATPase
art_RS03125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
art_RS03135	COG0215	cysteine-tRNA ligase activity
art_RS03140	COG1968	undecaprenyl-diphosphatase activity
art_RS03145	COG0667	Aldo Keto reductase
art_RS03165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
art_RS03190	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS03195	COG0183	Belongs to the thiolase family
art_RS03210	COG0297	glycogen (starch) synthase activity
art_RS03215	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
art_RS03225	COG2855	membrane
art_RS03240	COG0095	Lipoate-protein ligase
art_RS03245	COG0254	rRNA binding
art_RS03255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
art_RS03265	COG1119	ATPase activity
art_RS03270	COG3830	Belongs to the UPF0237 family
art_RS03270	COG0560	Phosphoserine phosphatase
art_RS03275	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS03280	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS03305	COG0488	(ABC) transporter
art_RS03310	COG1268	BioY protein
art_RS03315	COG1122	ATPase activity
art_RS03325	COG0183	Belongs to the thiolase family
art_RS03330	COG0318	PFAM AMP-dependent synthetase and ligase
art_RS03340	COG2151	metal-sulfur cluster biosynthetic enzyme
art_RS03345	COG0396	ATPase activity
art_RS03385	COG0109	protoheme IX farnesyltransferase activity
art_RS03395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
art_RS03400	COG0166	Belongs to the GPI family
art_RS03415	COG0363	glucosamine-6-phosphate deaminase activity
art_RS03420	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
art_RS03425	COG0149	triose-phosphate isomerase activity
art_RS03430	COG0126	phosphoglycerate kinase activity
art_RS03435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
art_RS03440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
art_RS03445	COG1481	regulation of sporulation
art_RS03450	COG0391	Required for morphogenesis under gluconeogenic growth conditions
art_RS03455	COG1660	Displays ATPase and GTPase activities
art_RS03460	COG0322	excinuclease ABC activity
art_RS03500	COG3550	peptidyl-serine autophosphorylation
art_RS03510	COG4106	trans-aconitate 2-methyltransferase activity
art_RS03530	COG4989	oxidoreductase activity
art_RS03535	COG0556	nucleotide-excision repair
art_RS03545	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
art_RS03545	COG0237	dephospho-CoA kinase activity
art_RS03550	COG0277	FAD linked oxidase domain protein
art_RS03555	COG1672	PFAM Archaeal ATPase
art_RS03555	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
art_RS03560	COG1739	Uncharacterized protein family UPF0029
art_RS03565	COG3152	Membrane
art_RS03575	COG0539	negative regulation of cytoplasmic translation
art_RS03585	COG4552	Acetyltransferase involved in intracellular survival and related
art_RS03595	COG2050	protein possibly involved in aromatic compounds catabolism
art_RS03635	COG0318	PFAM AMP-dependent synthetase and ligase
art_RS03640	COG2261	transglycosylase associated protein
art_RS03670	COG0673	inositol 2-dehydrogenase activity
art_RS03675	COG1609	Transcriptional regulator
art_RS03700	COG0109	protoheme IX farnesyltransferase activity
art_RS03715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
art_RS03720	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
art_RS03725	COG0009	L-threonylcarbamoyladenylate synthase
art_RS03730	COG0783	Belongs to the Dps family
art_RS03735	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS03740	COG1643	Atp-dependent helicase
art_RS03755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
art_RS03775	COG2268	Band 7 protein
art_RS03800	COG2197	response regulator
art_RS03835	COG2217	Heavy metal translocating P-type atpase
art_RS03870	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
art_RS03905	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
art_RS03910	COG0135	phosphoribosylanthranilate isomerase activity
art_RS03935	COG3119	arylsulfatase activity
art_RS03945	COG0025	NhaP-type Na H and K H
art_RS03950	COG2814	Major facilitator Superfamily
art_RS03960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
art_RS03965	COG1121	(ABC) transporter
art_RS03985	COG3119	arylsulfatase activity
art_RS03995	COG0395	ABC-type sugar transport system, permease component
art_RS04010	COG1609	Transcriptional regulator
art_RS04050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
art_RS04055	COG1845	cytochrome c oxidase, subunit III
art_RS04060	COG2010	Cytochrome c
art_RS04065	COG0723	plastoquinol--plastocyanin reductase activity
art_RS04070	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
art_RS04075	COG2188	Transcriptional regulator
art_RS04090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
art_RS04095	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
art_RS04115	COG0667	Aldo Keto reductase
art_RS04120	COG0167	dihydroorotate dehydrogenase activity
art_RS04135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
art_RS04140	COG1381	Involved in DNA repair and RecF pathway recombination
art_RS04145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
art_RS04150	COG3590	peptidase
art_RS04160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
art_RS04170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
art_RS04190	COG0484	heat shock protein binding
art_RS04195	COG1420	regulation of RNA biosynthetic process
art_RS04210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
art_RS04215	COG0481	GTPase activity
art_RS04225	COG0268	Binds directly to 16S ribosomal RNA
art_RS04235	COG3387	PFAM Glycoside hydrolase 15-related
art_RS04240	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS04270	COG0028	Belongs to the TPP enzyme family
art_RS04335	COG1307	EDD domain protein, DegV family
art_RS04340	COG0495	leucyl-tRNA aminoacylation
art_RS04345	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
art_RS04350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
art_RS04355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
art_RS04360	COG2390	Transcriptional regulator
art_RS04365	COG0656	L-ascorbic acid biosynthetic process
art_RS04390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
art_RS04395	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
art_RS04405	COG1758	RNA polymerase activity
art_RS04410	COG0194	GDP metabolic process
art_RS04415	COG0194	GDP metabolic process
art_RS04420	COG0284	orotidine-5'-phosphate decarboxylase activity
art_RS04425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
art_RS04430	COG0505	Belongs to the CarA family
art_RS04440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
art_RS04445	COG0540	Belongs to the ATCase OTCase family
art_RS04450	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
art_RS04460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
art_RS04465	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
art_RS04475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
art_RS04480	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
art_RS04485	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
art_RS04490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
art_RS04500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
art_RS04505	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
art_RS04520	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
art_RS04545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
art_RS04550	COG0124	histidyl-tRNA synthetase
art_RS04560	COG1196	nuclear chromosome segregation
art_RS04570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
art_RS04575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
art_RS04580	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
art_RS04590	COG2255	four-way junction helicase activity
art_RS04595	COG0632	four-way junction helicase activity
art_RS04600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
art_RS04605	COG0217	transcriptional regulatory protein
art_RS04610	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
art_RS04615	COG0367	asparagine synthase
art_RS04630	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
art_RS04635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
art_RS04645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
art_RS04650	COG0587	DNA-directed DNA polymerase activity
art_RS04660	COG0456	acetyltransferase
art_RS04670	COG2135	peptidase activity
art_RS04675	COG0180	Tryptophanyl-tRNA synthetase
art_RS04715	COG0318	PFAM AMP-dependent synthetase and ligase
art_RS04725	COG4682	membrane
art_RS04730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
art_RS04735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
art_RS04740	COG1780	Probably involved in ribonucleotide reductase function
art_RS04750	COG0738	Major facilitator superfamily
art_RS04755	COG3226	Transcriptional regulator
art_RS04760	COG0110	maltose O-acetyltransferase activity
art_RS04765	COG0583	DNA-binding transcription factor activity
art_RS04770	COG1012	belongs to the aldehyde dehydrogenase family
art_RS04795	COG2890	protein-(glutamine-N5) methyltransferase activity
art_RS04800	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
art_RS04805	COG3012	SEC-C Motif Domain Protein
art_RS04810	COG2188	Transcriptional regulator
art_RS04835	COG0799	negative regulation of ribosome biogenesis
art_RS04845	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
art_RS04855	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
art_RS04875	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
art_RS04880	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
art_RS04885	COG0211	Belongs to the bacterial ribosomal protein bL27 family
art_RS04890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
art_RS04895	COG0351	phosphomethylpyrimidine kinase
art_RS04895	COG0352	thiamine-phosphate diphosphorylase activity
art_RS04895	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
art_RS04900	COG1530	ribonuclease E activity
art_RS04910	COG0105	UTP biosynthetic process
art_RS04920	COG0285	dihydrofolate synthase activity
art_RS04925	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
art_RS04935	COG3189	MarR family transcriptional regulator
art_RS04945	COG0525	valine-tRNA ligase activity
art_RS04955	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
art_RS04960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
art_RS04960	COG0438	transferase activity, transferring glycosyl groups
art_RS04975	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
art_RS04980	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
art_RS04985	COG0740	serine-type endopeptidase activity
art_RS04990	COG0740	serine-type endopeptidase activity
art_RS04995	COG0544	peptidyl-prolyl cis-trans isomerase activity
art_RS05015	COG0698	ribose 5-phosphate isomerase
art_RS05040	COG0668	transmembrane transport
art_RS05060	COG1946	Acyl-CoA thioesterase
art_RS05110	COG1764	response to oxidative stress
art_RS05115	COG1846	Transcriptional regulator
art_RS05125	COG1064	alcohol dehydrogenase
art_RS05150	COG1073	alpha beta
art_RS05180	COG2197	response regulator
art_RS05205	COG2072	flavoprotein involved in K transport
art_RS05220	COG0076	glutamate decarboxylase activity
art_RS05225	COG2890	protein-(glutamine-N5) methyltransferase activity
art_RS05260	COG0477	Major facilitator Superfamily
art_RS05270	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
art_RS05275	COG2267	carboxylic ester hydrolase activity
art_RS05300	COG3022	response to hydroperoxide
art_RS05305	COG0346	lactoylglutathione lyase activity
art_RS05315	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
art_RS05320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
art_RS05330	COG1045	serine acetyltransferase
art_RS05340	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
art_RS05345	COG1063	alcohol dehydrogenase
art_RS05350	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS05365	COG0477	Major facilitator Superfamily
art_RS05380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
art_RS05405	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
art_RS05420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
art_RS05425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
art_RS05430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
art_RS05440	COG4974	Belongs to the 'phage' integrase family
art_RS05445	COG1316	TRANSCRIPTIONal
art_RS05450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
art_RS05450	COG0758	DNA mediated transformation
art_RS05460	COG0792	nuclease activity
art_RS05470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
art_RS05480	COG0681	Belongs to the peptidase S26 family
art_RS05485	COG0335	large ribosomal subunit rRNA binding
art_RS05490	COG0336	Belongs to the RNA methyltransferase TrmD family
art_RS05495	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
art_RS05500	COG1837	Belongs to the UPF0109 family
art_RS05505	COG0228	four-way junction DNA binding
art_RS05515	COG2514	catechol 2,3-dioxygenase activity
art_RS05535	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
art_RS05565	COG2814	Major facilitator Superfamily
art_RS05575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
art_RS05580	COG0318	PFAM AMP-dependent synthetase and ligase
art_RS05585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
art_RS05605	COG0584	glycerophosphoryl diester phosphodiesterase
art_RS05615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
art_RS05620	COG0571	ribonuclease III activity
art_RS05625	COG0333	Belongs to the bacterial ribosomal protein bL32 family
art_RS05640	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
art_RS05660	COG0673	inositol 2-dehydrogenase activity
art_RS05665	COG0742	ribosomal rna small subunit methyltransferase
art_RS05670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
art_RS05705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
art_RS05710	COG0798	PFAM Bile acid sodium symporter
art_RS05715	COG0640	Transcriptional regulator
art_RS05720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
art_RS05745	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
art_RS05755	COG2337	Toxic component of a toxin-antitoxin (TA) module
art_RS05760	COG1960	acyl-CoA dehydrogenase activity
art_RS05765	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
art_RS05770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
art_RS05780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
art_RS05785	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
art_RS05790	COG1695	Transcriptional regulator
art_RS05815	COG1215	transferase activity, transferring glycosyl groups
art_RS05815	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
art_RS05830	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
art_RS05835	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
art_RS05840	COG0438	transferase activity, transferring glycosyl groups
art_RS05855	COG0110	maltose O-acetyltransferase activity
art_RS05860	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
art_RS05870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
art_RS05890	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
art_RS05890	COG0463	Glycosyl transferase, family 2
art_RS05890	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
art_RS05890	COG0463	Glycosyl transferase, family 2
art_RS05895	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
art_RS05905	COG1388	LysM domain
art_RS05905	COG1134	teichoic acid transport
art_RS05930	COG1316	TRANSCRIPTIONal
art_RS05940	COG1609	Transcriptional regulator
art_RS05950	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
art_RS05955	COG4821	SIS domain
art_RS05960	COG0363	glucosamine-6-phosphate deaminase activity
art_RS05995	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
art_RS06005	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
art_RS06015	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
art_RS06035	COG1181	Belongs to the D-alanine--D-alanine ligase family
art_RS06040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
art_RS06050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
art_RS06075	COG0066	3-isopropylmalate dehydratase activity
art_RS06080	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
art_RS06085	COG1414	Transcriptional regulator
art_RS06110	COG3237	CsbD-like
art_RS06140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
art_RS06165	COG1113	amino acid transport
art_RS06180	COG2197	response regulator
art_RS06185	COG4585	Histidine kinase
art_RS06195	COG0179	Fumarylacetoacetate (FAA) hydrolase
art_RS06200	COG2116	formate transmembrane transporter activity
art_RS06210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
art_RS06220	COG2814	Major facilitator Superfamily
art_RS06225	COG0473	3-isopropylmalate dehydrogenase activity
art_RS06230	COG4585	Histidine kinase
art_RS06235	COG2197	response regulator
art_RS06245	COG1175	transmembrane transport
art_RS06250	COG1653	transport
art_RS06275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
art_RS06280	COG0577	efflux transmembrane transporter activity
art_RS06280	COG1136	(ABC) transporter
art_RS06300	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS06305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
art_RS06350	COG3119	arylsulfatase activity
art_RS06355	COG1940	carbohydrate kinase activity
art_RS06365	COG0395	ABC-type sugar transport system, permease component
art_RS06370	COG1175	transmembrane transport
art_RS06380	COG1940	carbohydrate kinase activity
art_RS06390	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
art_RS06395	COG0440	acetolactate synthase activity
art_RS06405	COG0129	dihydroxy-acid dehydratase activity
art_RS06420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
art_RS06445	COG0579	oxidoreductase
art_RS06450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
art_RS06465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
art_RS06470	COG1846	Transcriptional regulator
art_RS06490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
art_RS06495	COG0179	Fumarylacetoacetate (FAA) hydrolase
art_RS06515	COG2205	protein histidine kinase activity
art_RS06545	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
art_RS06550	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
art_RS06560	COG1113	amino acid transport
art_RS06575	COG0419	ATPase involved in DNA repair
art_RS06580	COG0420	3'-5' exonuclease activity
art_RS06600	COG2149	membrane
art_RS06630	COG1131	(ABC) transporter
art_RS06635	COG2188	Transcriptional regulator
art_RS06645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
art_RS06650	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
art_RS06665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
art_RS06675	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
art_RS06680	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
art_RS06685	COG1335	isochorismatase
art_RS06700	COG0363	glucosamine-6-phosphate deaminase activity
art_RS06715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
art_RS06730	COG0628	permease
art_RS06745	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
art_RS06750	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
art_RS06755	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
art_RS06770	COG0355	proton-transporting ATP synthase activity, rotational mechanism
art_RS06775	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
art_RS06780	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
art_RS06785	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
art_RS06790	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
art_RS06795	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
art_RS06800	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
art_RS06805	COG0356	it plays a direct role in the translocation of protons across the membrane
art_RS06820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
art_RS06825	COG1086	Polysaccharide biosynthesis protein
art_RS06835	COG1216	Glycosyl transferase, family 2
art_RS06845	COG0009	L-threonylcarbamoyladenylate synthase
art_RS06850	COG2890	protein-(glutamine-N5) methyltransferase activity
art_RS06855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
art_RS06865	COG0083	homoserine kinase activity
art_RS06870	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
art_RS06875	COG0460	homoserine dehydrogenase
art_RS06880	COG0019	diaminopimelate decarboxylase activity
art_RS06885	COG0018	arginyl-trna synthetase
art_RS06915	COG1136	(ABC) transporter
art_RS06915	COG4591	ABC-type transport system involved in lipoprotein release permease component
art_RS06925	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
art_RS06930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
art_RS06955	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
art_RS06975	COG1414	Transcriptional regulator
art_RS06985	COG0477	Major facilitator Superfamily
art_RS06990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
art_RS07015	COG1760	l-serine dehydratase
art_RS07030	COG0697	spore germination
art_RS07035	COG1846	Transcriptional regulator
art_RS07045	COG1643	Atp-dependent helicase
art_RS07050	COG2161	toxin-antitoxin pair type II binding
art_RS07055	COG4115	mRNA cleavage
art_RS07075	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS07080	COG0537	adenosine 5'-monophosphoramidase activity
art_RS07085	COG1064	alcohol dehydrogenase
art_RS07095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
art_RS07100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
art_RS07115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
art_RS07120	COG1120	ATPase activity
art_RS07125	COG0803	Belongs to the bacterial solute-binding protein 9 family
art_RS07135	COG1253	flavin adenine dinucleotide binding
art_RS07150	COG3265	gluconokinase activity
art_RS07155	COG2186	Transcriptional regulator
art_RS07160	COG1063	alcohol dehydrogenase
art_RS07170	COG1175	transmembrane transport
art_RS07180	COG4948	Mandelate Racemase Muconate Lactonizing
art_RS07185	COG3265	gluconokinase activity
art_RS07190	COG4948	Mandelate Racemase Muconate Lactonizing
art_RS07195	COG0246	Mannitol dehydrogenase
art_RS07200	COG1904	glucuronate isomerase
art_RS07205	COG1609	Transcriptional regulator
art_RS07220	COG0673	inositol 2-dehydrogenase activity
art_RS07230	COG1609	Transcriptional regulator
art_RS07235	COG1609	Transcriptional regulator
art_RS07245	COG1175	transmembrane transport
art_RS07250	COG0395	ABC-type sugar transport system, permease component
art_RS07260	COG0567	Dehydrogenase, E1 component
art_RS07260	COG0508	dehydrogenase complex catalyzes the overall conversion of
art_RS07295	COG1595	DNA-templated transcription, initiation
art_RS07305	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
art_RS07315	COG0483	inositol monophosphate 1-phosphatase activity
art_RS07320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
art_RS07335	COG1321	iron dependent repressor
art_RS07345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
art_RS07370	COG2909	trisaccharide binding
art_RS07720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
art_RS07730	COG2177	Part of the ABC transporter FtsEX involved in
art_RS07735	COG2884	Cell division ATP-binding protein ftsE
art_RS07740	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
art_RS07830	COG1132	(ABC) transporter
art_RS07875	COG0673	inositol 2-dehydrogenase activity
art_RS07900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
art_RS07910	COG1088	dTDP-glucose 4,6-dehydratase activity
art_RS07950	COG2755	lipolytic protein G-D-S-L family
art_RS07950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
art_RS07960	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
art_RS07980	COG1216	Glycosyl transferase, family 2
art_RS07990	COG1674	ftsk spoiiie
art_RS08010	COG2902	Dehydrogenase
art_RS08045	COG0653	protein targeting
art_RS08050	COG3214	Protein conserved in bacteria
art_RS08055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
art_RS08060	COG1040	competence protein
art_RS08065	COG5401	PFAM Sporulation and spore germination
art_RS08070	COG5002	protein histidine kinase activity
art_RS08070	COG5000	phosphorelay sensor kinase activity
art_RS08075	COG0745	RESPONSE REGULATOR receiver
art_RS08095	COG0714	Associated with various cellular activities
art_RS08125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
art_RS08130	COG0601	transmembrane transport
art_RS08145	COG0482	sulfurtransferase activity
art_RS08165	COG0302	gtp cyclohydrolase
art_RS08175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
art_RS08185	COG0484	heat shock protein binding
art_RS08190	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
art_RS08205	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
art_RS08210	COG2086	electron transfer activity
art_RS08225	COG1136	(ABC) transporter
art_RS08235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
art_RS08245	COG1842	Phage shock protein A
art_RS08250	COG0656	L-ascorbic acid biosynthetic process
art_RS08255	COG3585	molybdate ion transport
art_RS08300	COG1960	acyl-CoA dehydrogenase activity
art_RS08310	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
art_RS08320	COG1846	Transcriptional regulator
art_RS08330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
art_RS08335	COG0318	PFAM AMP-dependent synthetase and ligase
art_RS08340	COG1024	Enoyl-CoA hydratase
art_RS08345	COG1250	3-hydroxyacyl-CoA dehydrogenase
art_RS08345	COG1024	Enoyl-CoA hydratase
art_RS08350	COG0183	Belongs to the thiolase family
art_RS08355	COG1960	acyl-CoA dehydrogenase activity
art_RS08360	COG1024	Enoyl-CoA hydratase
art_RS08380	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS08405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
art_RS08425	COG0628	permease
art_RS08435	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
art_RS08440	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
art_RS08450	COG0490	domain, Protein
art_RS08450	COG0471	metal ion transport
art_RS08460	COG1615	UPF0182 protein
art_RS08465	COG3480	Lon protease (S16) C-terminal proteolytic domain
art_RS08490	COG2816	NAD+ diphosphatase activity
art_RS08525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
art_RS08530	COG0765	amino acid transport
art_RS08535	COG1126	abc transporter atp-binding protein
art_RS08560	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
art_RS08575	COG0181	hydroxymethylbilane synthase activity
art_RS08580	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
art_RS08585	COG3253	May function as heme-dependent peroxidase
art_RS08595	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
art_RS08600	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
art_RS08615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
art_RS08620	COG2011	ABC-type metal ion transport system permease component
art_RS08625	COG1464	Belongs to the NlpA lipoprotein family
art_RS08650	COG2022	thiamine diphosphate biosynthetic process
art_RS08660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
art_RS08660	COG2022	thiamine diphosphate biosynthetic process
art_RS08665	COG0352	thiamine-phosphate diphosphorylase activity
art_RS08670	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
art_RS08675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
art_RS08710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
art_RS08720	COG2072	flavoprotein involved in K transport
art_RS08745	COG2207	Transcriptional regulator
art_RS08800	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
art_RS08810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
art_RS08815	COG0509	glycine decarboxylation via glycine cleavage system
art_RS08820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
art_RS08825	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
art_RS08825	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
art_RS08830	COG1113	amino acid transport
art_RS08840	COG2814	Major facilitator Superfamily
art_RS08845	COG0477	Major facilitator Superfamily
art_RS08850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
art_RS08870	COG0513	Belongs to the DEAD box helicase family
art_RS08885	COG0613	PHP domain protein
art_RS08890	COG0006	proline dipeptidase activity
art_RS08900	COG2239	Acts as a magnesium transporter
art_RS08920	COG1595	DNA-templated transcription, initiation
art_RS08935	COG2818	Glycosylase
art_RS08950	COG1126	abc transporter atp-binding protein
art_RS08955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
art_RS08960	COG0765	amino acid transport
art_RS08965	COG0765	amino acid transport
art_RS08970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
art_RS08980	COG2171	N-acyltransferase activity
art_RS09030	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
art_RS09035	COG4172	Belongs to the ABC transporter superfamily
art_RS09040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
art_RS09045	COG0601	transmembrane transport
art_RS09055	COG1217	gtp-binding protein TYPA
art_RS09060	COG2197	response regulator
art_RS09065	COG4585	Histidine kinase
art_RS09075	COG1131	(ABC) transporter
art_RS09095	COG0747	negative chemotaxis
art_RS09100	COG2318	DinB family
art_RS09150	COG2211	Major facilitator Superfamily
art_RS09160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
art_RS09165	COG2186	Transcriptional regulator
art_RS09200	COG0012	GTP binding
art_RS09210	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
art_RS09220	COG1570	exodeoxyribonuclease VII activity
art_RS09225	COG1722	exodeoxyribonuclease VII activity
art_RS09235	COG2326	polyphosphate kinase activity
art_RS09255	COG1609	Transcriptional regulator
art_RS09260	COG2971	BadF BadG BcrA BcrD
art_RS09265	COG2070	2-Nitropropane dioxygenase
art_RS09275	COG0598	Magnesium transport protein CorA
art_RS09285	COG0778	Nitroreductase
art_RS09295	COG0039	L-malate dehydrogenase activity
art_RS09300	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
art_RS09305	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
art_RS09325	COG1309	transcriptional regulator
art_RS09330	COG1131	(ABC) transporter
art_RS09350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
art_RS09350	COG4499	WXG100 protein secretion system (Wss), protein YukC
art_RS09360	COG0488	(ABC) transporter
art_RS09365	COG0412	Dienelactone hydrolase
art_RS09425	COG2186	Transcriptional regulator
art_RS09435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
art_RS09445	COG2160	L-arabinose isomerase activity
art_RS09460	COG1609	Transcriptional regulator
art_RS09490	COG1063	alcohol dehydrogenase
art_RS09630	COG1210	Utp--glucose-1-phosphate uridylyltransferase
art_RS09635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
art_RS09660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
art_RS09660	COG0519	Catalyzes the synthesis of GMP from XMP
art_RS09680	COG0516	GMP reductase activity
art_RS09700	COG2217	Heavy metal translocating P-type atpase
art_RS09705	COG0459	protein refolding
art_RS09710	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
art_RS09765	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
art_RS09770	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
art_RS09775	COG0671	phosphoesterase, PA-phosphatase related
art_RS09790	COG5002	protein histidine kinase activity
art_RS09810	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
art_RS09815	COG0456	acetyltransferase
art_RS09825	COG0802	atpase or kinase
art_RS09830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
art_RS09835	COG0438	transferase activity, transferring glycosyl groups
art_RS09840	COG1404	Belongs to the peptidase S8 family
art_RS09850	COG0366	Alpha amylase catalytic
art_RS09860	COG1260	myo-inositol-1-phosphate synthase
art_RS09865	COG0667	Aldo Keto reductase
art_RS09880	COG0736	holo-[acyl-carrier-protein] synthase activity
art_RS09885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
art_RS09890	COG1072	(Pantothenic acid kinase))
art_RS09900	COG1970	mechanosensitive ion channel activity
art_RS09905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
art_RS09910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
art_RS09915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
art_RS09920	COG0101	tRNA pseudouridine synthase activity
art_RS09925	COG0203	ribosomal protein L17
art_RS09930	COG0202	RNA polymerase activity
art_RS09935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
art_RS09940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
art_RS09945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
art_RS09950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
art_RS09960	COG1653	transport
art_RS09965	COG0395	ABC-type sugar transport system, permease component
art_RS09970	COG1175	transmembrane transport
art_RS09985	COG0563	adenylate kinase activity
art_RS09995	COG0200	Binds to the 23S rRNA
art_RS10000	COG1841	ribosomal large subunit assembly
art_RS10005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
art_RS10010	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
art_RS10015	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
art_RS10020	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
art_RS10025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
art_RS10030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
art_RS10035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
art_RS10040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
art_RS10045	COG0255	Belongs to the universal ribosomal protein uL29 family
art_RS10050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
art_RS10055	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
art_RS10060	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
art_RS10065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
art_RS10070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
art_RS10075	COG0089	rRNA binding
art_RS10080	COG0088	Forms part of the polypeptide exit tunnel
art_RS10085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
art_RS10090	COG0051	transcription antitermination factor activity, RNA binding
art_RS10115	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
art_RS10120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
art_RS10125	COG0049	tRNA binding
art_RS10130	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
art_RS10135	COG1752	Esterase of the alpha-beta hydrolase superfamily
art_RS10140	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
art_RS10145	COG0085	RNA polymerase activity
art_RS10150	COG0183	Belongs to the thiolase family
art_RS10155	COG0442	prolyl-tRNA aminoacylation
art_RS10160	COG0222	ribosome binding
art_RS10165	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
art_RS10180	COG0081	regulation of translation
art_RS10185	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
art_RS10190	COG0250	Participates in transcription elongation, termination and antitermination
art_RS10205	COG0436	Aminotransferase
art_RS10210	COG2197	response regulator
art_RS10250	COG3485	protocatechuate 3,4-dioxygenase
art_RS10260	COG0745	RESPONSE REGULATOR receiver
art_RS10265	COG0456	acetyltransferase
art_RS10270	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
art_RS10275	COG0494	nUDIX hydrolase
art_RS10275	COG0406	alpha-ribazole phosphatase activity
art_RS10295	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
art_RS10310	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
art_RS10325	COG0812	UDP-N-acetylmuramate dehydrogenase activity
art_RS10340	COG2030	dehydratase
art_RS10350	COG0477	Major facilitator Superfamily
art_RS10375	COG2301	Belongs to the HpcH HpaI aldolase family
art_RS10395	COG0702	epimerase
art_RS10420	COG0477	Major facilitator Superfamily
art_RS10440	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
art_RS10445	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
art_RS10450	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
art_RS10455	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS10460	COG0402	S-adenosylhomocysteine deaminase activity
art_RS10465	COG1652	LysM domain
art_RS10510	COG1012	belongs to the aldehyde dehydrogenase family
art_RS10540	COG1063	alcohol dehydrogenase
art_RS10550	COG2376	Dihydroxyacetone kinase
art_RS10555	COG0698	ribose 5-phosphate isomerase
art_RS10560	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS10570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
art_RS10575	COG2814	Major facilitator Superfamily
art_RS10615	COG1666	GTP binding
art_RS10630	COG4585	Histidine kinase
art_RS10635	COG0406	alpha-ribazole phosphatase activity
art_RS10650	COG2826	transposase and inactivated derivatives, IS30 family
art_RS10655	COG0753	catalase activity
art_RS10675	COG0531	amino acid
art_RS10700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
art_RS10735	COG1012	belongs to the aldehyde dehydrogenase family
art_RS10755	COG2188	Transcriptional regulator
art_RS10765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
art_RS10765	COG1648	precorrin-2 dehydrogenase activity
art_RS10775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
art_RS10780	COG1116	anion transmembrane transporter activity
art_RS10830	COG0175	sulfate reduction
art_RS10835	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
art_RS10860	COG4152	abc transporter atp-binding protein
art_RS10865	COG2860	membrane
art_RS10885	COG0142	geranyltranstransferase activity
art_RS10895	COG2226	methyltransferase
art_RS10900	COG1169	isochorismate synthase
art_RS10905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
art_RS10910	COG0765	amino acid transport
art_RS10920	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
art_RS10925	COG4948	Mandelate Racemase Muconate Lactonizing
art_RS10950	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
art_RS10960	COG1597	lipid kinase activity
art_RS10975	COG0277	FAD linked oxidase domain protein
art_RS10990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
art_RS10995	COG2151	metal-sulfur cluster biosynthetic enzyme
art_RS11000	COG3396	Phenylacetate-CoA oxygenase
art_RS11005	COG3460	Phenylacetate-CoA oxygenase
art_RS11010	COG3396	Phenylacetate-CoA oxygenase
art_RS11040	COG1012	belongs to the aldehyde dehydrogenase family
art_RS11040	COG2030	dehydratase
art_RS11045	COG1250	3-hydroxyacyl-CoA dehydrogenase
art_RS11050	COG1024	Enoyl-CoA hydratase
art_RS11065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
art_RS11075	COG0076	glutamate decarboxylase activity
art_RS11080	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
art_RS11085	COG0280	phosphate acetyltransferase
art_RS11085	COG0857	belongs to the CobB CobQ family
art_RS11120	COG0488	(ABC) transporter
art_RS11140	COG0653	protein targeting
art_RS11150	COG2365	Tyrosine phosphatase family
art_RS11165	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
art_RS11215	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
art_RS11265	COG4804	nuclease activity
art_RS11275	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
art_RS11280	COG4942	peptidase
art_RS11325	COG1309	transcriptional regulator
art_RS11345	COG0386	Belongs to the glutathione peroxidase family
art_RS11365	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
art_RS11375	COG0129	dihydroxy-acid dehydratase activity
art_RS11385	COG4555	ABC transporter
art_RS11415	COG1012	belongs to the aldehyde dehydrogenase family
art_RS11425	COG2076	Multidrug Resistance protein
art_RS11430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
art_RS11455	COG1846	Transcriptional regulator
art_RS11500	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
art_RS11505	COG0047	phosphoribosylformylglycinamidine synthase activity
art_RS11510	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
art_RS11530	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
art_RS11545	COG1832	CoA-binding protein
art_RS11560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
art_RS11565	COG1794	racemase activity, acting on amino acids and derivatives
art_RS11570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
art_RS11575	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS11585	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS11610	COG0477	Major facilitator Superfamily
art_RS11640	COG0191	fructose-bisphosphate aldolase activity
art_RS11645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
art_RS11645	COG0357	Ribosomal RNA small subunit methyltransferase G
art_RS11660	COG1435	thymidine kinase activity
art_RS11670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
art_RS11675	COG1435	thymidine kinase activity
art_RS11680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
art_RS11685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
art_RS11690	COG0800	Aldolase
art_RS11695	COG4948	Mandelate Racemase Muconate Lactonizing
art_RS11700	COG0395	ABC-type sugar transport system, permease component
art_RS11705	COG1175	transmembrane transport
art_RS11715	COG1802	Transcriptional regulator
art_RS11725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
art_RS11735	COG4176	ABC-type proline glycine betaine transport system permease component
art_RS11740	COG0517	IMP dehydrogenase activity
art_RS11740	COG4175	Glycine betaine
art_RS11755	COG1609	Transcriptional regulator
art_RS11830	COG3103	Sh3 type 3 domain protein
art_RS11830	COG1388	LysM domain
art_RS11830	COG0791	NLP P60 protein
art_RS11855	COG2372	response to copper ion
art_RS11860	COG2252	PERMEase
art_RS11865	COG0010	Belongs to the arginase family
art_RS11910	COG4122	O-methyltransferase activity
art_RS11915	COG1819	glycosyl
art_RS11935	COG3387	PFAM Glycoside hydrolase 15-related
art_RS11945	COG2733	membrane
art_RS11980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
art_RS11980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
art_RS11980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
art_RS11985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
art_RS11990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
art_RS11995	COG0477	Major facilitator Superfamily
art_RS12000	COG4221	oxidoreductase activity
art_RS12010	COG0351	phosphomethylpyrimidine kinase
art_RS12015	COG1335	isochorismatase
art_RS12045	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS12095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
art_RS12110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
art_RS12125	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
art_RS12155	COG1461	Dihydroxyacetone kinase
art_RS12160	COG2376	Dihydroxyacetone kinase
art_RS12165	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
art_RS12170	COG3548	integral membrane protein
art_RS12185	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
art_RS12190	COG1609	Transcriptional regulator
art_RS12195	COG1957	nucleoside hydrolase
art_RS12200	COG0477	Major facilitator Superfamily
art_RS12205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
art_RS12210	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
art_RS12240	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
art_RS12250	COG0302	gtp cyclohydrolase
art_RS12255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
art_RS12265	COG0037	tRNA processing
art_RS12290	COG0561	phosphatase activity
art_RS12295	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
art_RS12300	COG1597	lipid kinase activity
art_RS12310	COG1054	Belongs to the UPF0176 family
art_RS12315	COG3104	oligopeptide transport
art_RS12340	COG2233	PERMEase
art_RS12360	COG1802	Transcriptional regulator
art_RS12380	COG3938	Belongs to the proline racemase family
art_RS12425	COG1929	Belongs to the glycerate kinase type-1 family
art_RS12435	COG0561	phosphatase activity
art_RS12465	COG4585	Histidine kinase
art_RS12535	COG1063	alcohol dehydrogenase
art_RS12545	COG0477	Major facilitator Superfamily
art_RS12555	COG3119	arylsulfatase activity
art_RS12565	COG0395	ABC-type sugar transport system, permease component
art_RS12570	COG1175	transmembrane transport
art_RS12580	COG3119	arylsulfatase activity
art_RS12585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
art_RS12600	COG1556	Lactate utilization protein
art_RS12605	COG1139	Iron-sulfur cluster binding protein
art_RS12610	COG0247	lactate metabolic process
art_RS12625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
art_RS12630	COG1012	belongs to the aldehyde dehydrogenase family
art_RS12635	COG0028	Belongs to the TPP enzyme family
art_RS12640	COG2508	Transcriptional regulator
art_RS12645	COG0477	Major facilitator Superfamily
art_RS12650	COG0251	oxidation-reduction process
art_RS12655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
art_RS12660	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
art_RS12670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
art_RS12675	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
art_RS12720	COG3853	Toxic anion resistance protein (TelA)
art_RS12750	COG1358	cellular component organization or biogenesis
art_RS12765	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
art_RS12770	COG0251	oxidation-reduction process
art_RS12775	COG4172	Belongs to the ABC transporter superfamily
art_RS12780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
art_RS12785	COG0601	transmembrane transport
art_RS12790	COG0747	negative chemotaxis
art_RS12805	COG1609	Transcriptional regulator
art_RS12870	COG1362	aminopeptidase activity
art_RS12885	COG2197	response regulator
art_RS12890	COG4585	Histidine kinase
art_RS12910	COG0738	Major facilitator superfamily
art_RS12925	COG0488	(ABC) transporter
art_RS12930	COG4585	Histidine kinase
art_RS12935	COG2197	response regulator
art_RS12940	COG4152	abc transporter atp-binding protein
art_RS12955	COG2197	response regulator
art_RS12965	COG2197	response regulator
art_RS12970	COG3850	Histidine kinase
art_RS13000	COG0406	alpha-ribazole phosphatase activity
art_RS13005	COG0617	tRNA 3'-terminal CCA addition
art_RS13025	COG0492	ferredoxin-NADP+ reductase activity
art_RS13030	COG3118	belongs to the thioredoxin family
art_RS13075	COG1192	Involved in chromosome partitioning
art_RS13080	COG0357	Ribosomal RNA small subunit methyltransferase G
art_RS13090	COG0706	membrane insertase activity
art_RS13095	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
art_RS13100	COG0592	DNA-directed DNA polymerase activity
art_RS13105	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
art_RS13110	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
art_RS13115	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
art_RS13120	COG0187	DNA topoisomerase II activity
art_RS13125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
art_RS13130	COG3266	domain, Protein
art_RS13160	COG0705	Rhomboid family
art_RS13180	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
art_RS13210	COG3764	Sortase (surface protein transpeptidase)
art_RS13225	COG0515	serine threonine protein kinase
art_RS13230	COG0515	serine threonine protein kinase
art_RS13235	COG0768	penicillin binding
art_RS13250	COG1716	ATPase activity
art_RS13255	COG1716	ATPase activity
art_RS13315	COG0360	Binds together with S18 to 16S ribosomal RNA
art_RS13325	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
art_RS13330	COG0359	binds to the 23S rRNA
art_RS13340	COG0305	Participates in initiation and elongation during chromosome replication
art_RS13370	COG4821	SIS domain
art_RS13375	COG1653	transport
art_RS13380	COG1175	transmembrane transport
art_RS13385	COG0395	ABC-type sugar transport system, permease component
art_RS13410	COG1937	Protein conserved in bacteria
art_RS13420	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
art_RS13445	COG1063	alcohol dehydrogenase
art_RS13450	COG0395	ABC-type sugar transport system, permease component
art_RS13465	COG2390	Transcriptional regulator
art_RS13470	COG1070	Carbohydrate kinase
art_RS13480	COG0028	Belongs to the TPP enzyme family
art_RS13500	COG0820	rRNA (adenine-C2-)-methyltransferase activity
art_RS13520	COG0436	Aminotransferase
art_RS13525	COG1607	acyl-coa hydrolase
art_RS13535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
art_RS13550	COG1950	PFAM Membrane protein of
art_RS13555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
art_RS13565	COG0022	dehydrogenase e1 component
art_RS13570	COG0508	dehydrogenase complex catalyzes the overall conversion of
art_RS13585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
art_RS13595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
art_RS13605	COG0673	inositol 2-dehydrogenase activity
art_RS13610	COG2211	Major facilitator Superfamily
art_RS13705	COG1174	glycine betaine transport
art_RS13710	COG1174	glycine betaine transport
art_RS13720	COG0346	lactoylglutathione lyase activity
art_RS13730	COG1262	PFAM Formylglycine-generating sulfatase enzyme
art_RS13815	COG0435	Glutathione S-transferase
art_RS13830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
art_RS13835	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
art_RS13840	COG1120	ATPase activity
art_RS13850	COG2764	glyoxalase bleomycin resistance protein dioxygenase
art_RS13860	COG1132	(ABC) transporter
art_RS13885	COG0227	Belongs to the bacterial ribosomal protein bL28 family
art_RS13890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
art_RS13895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
art_RS13900	COG0776	regulation of translation
art_RS13905	COG2372	response to copper ion
art_RS13905	COG1276	copper resistance
art_RS13920	COG0433	COG0433 Predicted ATPase
art_RS13930	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
art_RS13975	COG0475	glutathione-regulated potassium exporter activity
art_RS13985	COG0717	Belongs to the dCTP deaminase family
art_RS13995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
art_RS13995	COG2111	Na H antiporter
art_RS14000	COG1006	Multisubunit Na H antiporter MnhC subunit
art_RS14005	COG0651	ATP synthesis coupled electron transport
art_RS14010	COG1863	multisubunit Na H antiporter MnhE subunit
art_RS14015	COG2212	antiporter activity
art_RS14020	COG1320	monovalent cation:proton antiporter activity
art_RS14030	COG4721	ABC-type cobalt transport system, permease component
art_RS14035	COG1122	ATPase activity
art_RS14045	COG0039	L-malate dehydrogenase activity
art_RS14050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
art_RS14085	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
art_RS14110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
art_RS14120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
art_RS14125	COG1280	lysine exporter protein (LysE YggA)
art_RS14130	COG2132	Multicopper oxidase
art_RS14140	COG0500	methyltransferase
art_RS14145	COG0443	Heat shock 70 kDa protein
art_RS14150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
art_RS14155	COG0484	heat shock protein binding
art_RS14160	COG0789	Transcriptional regulator
art_RS14165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
art_RS14185	COG1140	nitrate reductase beta subunit
art_RS14195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
art_RS14215	COG2197	response regulator
art_RS14260	COG2197	response regulator
art_RS14265	COG4585	Histidine kinase
art_RS14295	COG1309	transcriptional regulator
art_RS14310	COG1476	TRANSCRIPTIONal
art_RS14330	COG1063	alcohol dehydrogenase
art_RS14335	COG0542	response to heat
art_RS14350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
art_RS14380	COG0151	Belongs to the GarS family
art_RS14385	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
art_RS14400	COG2824	Alkylphosphonate utilization operon protein PhnA
art_RS14415	COG1408	metallophosphoesterase
art_RS14420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
art_RS14440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
art_RS14450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
art_RS14465	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
art_RS14470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
art_RS14490	COG1228	amidohydrolase
art_RS14535	COG1205	dead DEAH box helicase
art_RS14535	COG1111	helicase
art_RS14545	COG1054	Belongs to the UPF0176 family
art_RS14550	COG2890	protein-(glutamine-N5) methyltransferase activity
art_RS14555	COG1285	pathogenesis
art_RS14560	COG1754	DNA topoisomerase type I activity
art_RS14560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
art_RS14565	COG0248	Ppx GppA phosphatase
art_RS14570	COG1082	Xylose isomerase domain protein TIM barrel
art_RS14575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
art_RS14580	COG2169	Transcriptional regulator
art_RS14580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
art_RS14595	COG0569	domain protein
art_RS14600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
art_RS14605	COG0123	including yeast histone deacetylase and acetoin utilization protein
art_RS14615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
art_RS14630	COG1175	transmembrane transport
art_RS14640	COG3250	beta-galactosidase activity
art_RS14665	COG1609	Transcriptional regulator
art_RS14685	COG3347	Dehydrogenase
art_RS14685	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS14690	COG1070	Carbohydrate kinase
art_RS14695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
art_RS14700	COG3458	cephalosporin-C deacetylase activity
art_RS14705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
art_RS14725	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
art_RS14740	COG2353	YceI-like domain
art_RS14745	COG0406	alpha-ribazole phosphatase activity
art_RS14750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
art_RS14755	COG0785	Cytochrome C biogenesis protein
art_RS14765	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
art_RS14785	COG0488	(ABC) transporter
art_RS14820	COG1132	(ABC) transporter
art_RS14825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
art_RS14835	COG2205	protein histidine kinase activity
art_RS14840	COG0745	RESPONSE REGULATOR receiver
art_RS14855	COG3842	ATPase activity
art_RS14860	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
art_RS14885	COG0673	inositol 2-dehydrogenase activity
art_RS14890	COG0673	inositol 2-dehydrogenase activity
art_RS14905	COG1609	Transcriptional regulator
art_RS14915	COG1175	transmembrane transport
art_RS14920	COG0395	ABC-type sugar transport system, permease component
art_RS14925	COG0673	inositol 2-dehydrogenase activity
art_RS14935	COG0823	Involved in the tonB-independent uptake of proteins
art_RS14940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
art_RS14950	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
art_RS14960	COG1476	TRANSCRIPTIONal
art_RS15000	COG4335	DNA alkylation repair
art_RS15005	COG1846	Transcriptional regulator
art_RS15050	COG3795	YCII-related domain
art_RS15090	COG3971	2-oxopent-4-enoate hydratase activity
art_RS15100	COG1012	belongs to the aldehyde dehydrogenase family
art_RS15115	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
art_RS15140	COG0604	alcohol dehydrogenase
art_RS15165	COG0343	queuine tRNA-ribosyltransferase activity
art_RS15225	COG0626	cystathionine gamma-synthase activity
art_RS15255	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
art_RS15320	COG0564	pseudouridine synthase activity
art_RS15340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
art_RS15345	COG1201	RNA secondary structure unwinding
art_RS15370	COG2205	protein histidine kinase activity
art_RS15375	COG0745	RESPONSE REGULATOR receiver
art_RS15400	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
art_RS15415	COG1846	Transcriptional regulator
art_RS15430	COG2062	phosphohistidine phosphatase, SixA
art_RS15440	COG3547	Transposase (IS116 IS110 IS902 family)
art_RS15445	COG2239	Acts as a magnesium transporter
art_RS15450	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
art_RS15455	COG1940	carbohydrate kinase activity
art_RS15465	COG4608	Belongs to the ABC transporter superfamily
art_RS15470	COG0444	Belongs to the ABC transporter superfamily
art_RS15480	COG0747	negative chemotaxis
art_RS15485	COG2186	Transcriptional regulator
art_RS15505	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
art_RS15515	COG1959	2 iron, 2 sulfur cluster binding
art_RS15530	COG0514	ATP-dependent DNA helicase (RecQ)
art_RS15535	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS15545	COG4948	Mandelate Racemase Muconate Lactonizing
art_RS15590	COG1505	serine-type exopeptidase activity
art_RS15610	COG3321	synthase
art_RS15610	COG0604	alcohol dehydrogenase
art_RS15610	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS15620	COG1966	Carbon starvation protein
art_RS15650	COG3842	ATPase activity
art_RS15670	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
art_RS15675	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
art_RS15695	COG0588	phosphoglycerate mutase activity
art_RS15700	COG0704	Plays a role in the regulation of phosphate uptake
art_RS15705	COG5002	protein histidine kinase activity
art_RS15710	COG0745	RESPONSE REGULATOR receiver
art_RS15725	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
art_RS15730	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
art_RS15735	COG0215	cysteine-tRNA ligase activity
art_RS15740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
art_RS15760	COG0366	Alpha amylase catalytic
art_RS15805	COG3833	ABC-type maltose transport systems, permease component
art_RS15810	COG0366	Alpha amylase catalytic
art_RS15815	COG0277	FAD linked oxidase domain protein
art_RS15825	COG3842	ATPase activity
art_RS15830	COG0402	S-adenosylhomocysteine deaminase activity
art_RS15835	COG1877	trehalose-phosphatase activity
art_RS15920	COG2084	Dehydrogenase
art_RS15930	COG1609	Transcriptional regulator
art_RS15950	COG0395	ABC-type sugar transport system, permease component
art_RS15955	COG3842	ATPase activity
art_RS15995	COG1401	restriction endodeoxyribonuclease activity
art_RS16010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
art_RS16080	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS16095	COG1172	Belongs to the binding-protein-dependent transport system permease family
art_RS16105	COG1072	(Pantothenic acid kinase))
art_RS16110	COG1609	Transcriptional regulator
art_RS16160	COG2801	Transposase and inactivated derivatives
art_RS16235	COG1653	transport
art_RS16240	COG1175	transmembrane transport
art_RS16245	COG0395	ABC-type sugar transport system, permease component
art_RS16250	COG1063	alcohol dehydrogenase
art_RS16255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
art_RS16270	COG0456	acetyltransferase
art_RS16280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
art_RS16285	COG0165	Argininosuccinate lyase
art_RS16290	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
art_RS16295	COG3842	ATPase activity
art_RS16320	COG2610	gluconate transmembrane transporter activity
art_RS16350	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
art_RS16355	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
art_RS16385	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS16410	COG0179	Fumarylacetoacetate (FAA) hydrolase
art_RS16415	COG0789	Transcriptional regulator
art_RS16435	COG2814	Major facilitator Superfamily
art_RS16440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
art_RS16445	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
art_RS16465	COG1122	ATPase activity
art_RS16470	COG1268	BioY protein
art_RS16475	COG1960	acyl-CoA dehydrogenase activity
art_RS16485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
art_RS16510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
art_RS16515	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS16520	COG1902	pentaerythritol trinitrate reductase activity
art_RS16525	COG1309	transcriptional regulator
art_RS16530	COG0477	Major facilitator Superfamily
art_RS16540	COG0318	PFAM AMP-dependent synthetase and ligase
art_RS16550	COG4770	biotin carboxylase activity
art_RS16555	COG2301	Belongs to the HpcH HpaI aldolase family
art_RS16600	COG0071	Belongs to the small heat shock protein (HSP20) family
art_RS16615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
art_RS16620	COG2197	response regulator
art_RS16630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
art_RS16680	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS16700	COG0783	Belongs to the Dps family
art_RS16715	COG1529	Aldehyde oxidase and xanthine dehydrogenase
art_RS16720	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
art_RS16725	COG2080	2 iron, 2 sulfur cluster binding
art_RS16740	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
art_RS16795	COG1793	dna ligase
art_RS16795	COG3285	dna ligase
art_RS16800	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
art_RS16815	COG0693	protein deglycase activity
art_RS16855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
art_RS16860	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
art_RS16865	COG1120	ATPase activity
art_RS16905	COG0477	Major facilitator Superfamily
art_RS16910	COG1250	3-hydroxyacyl-CoA dehydrogenase
art_RS16925	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
art_RS16930	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
art_RS16945	COG0477	Major facilitator Superfamily
art_RS16950	COG0028	Belongs to the TPP enzyme family
art_RS16960	COG2197	response regulator
art_RS16965	COG4585	Histidine kinase
art_RS16970	COG2409	Drug exporters of the RND superfamily
art_RS16980	COG2801	Transposase and inactivated derivatives
art_RS16990	COG3119	arylsulfatase activity
art_RS17000	COG4209	transmembrane transport
art_RS17015	COG0395	ABC-type sugar transport system, permease component
art_RS17045	COG0598	Magnesium transport protein CorA
art_RS17065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
art_RS17070	COG4133	protoheme IX ABC transporter activity
art_RS17090	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
art_RS17110	COG0444	Belongs to the ABC transporter superfamily
art_RS17135	COG3142	Participates in the control of copper homeostasis
art_RS17145	COG0702	epimerase
art_RS17160	COG0142	geranyltranstransferase activity
art_RS17185	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
art_RS17190	COG0415	Belongs to the DNA photolyase family
art_RS17195	COG2409	Drug exporters of the RND superfamily
art_RS17215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
art_RS17230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
art_RS17235	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
art_RS17240	COG0431	NADPH-dependent FMN reductase
art_RS17275	COG3655	Transcriptional regulator
art_RS17325	COG2197	response regulator
art_RS17345	COG2197	response regulator
art_RS17355	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS17370	COG1012	belongs to the aldehyde dehydrogenase family
art_RS17410	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
art_RS17430	COG0459	protein refolding
art_RS17435	COG0328	RNA-DNA hybrid ribonuclease activity
art_RS17450	COG2205	protein histidine kinase activity
art_RS17455	COG0745	RESPONSE REGULATOR receiver
art_RS17460	COG3119	arylsulfatase activity
art_RS17465	COG3119	arylsulfatase activity
art_RS17470	COG0395	ABC-type sugar transport system, permease component
art_RS17485	COG1609	Transcriptional regulator
art_RS17490	COG0673	inositol 2-dehydrogenase activity
art_RS17495	COG5492	domain, Protein
art_RS17505	COG3119	arylsulfatase activity
art_RS17515	COG3119	arylsulfatase activity
art_RS17540	COG1278	Cold shock
art_RS17565	COG0791	NLP P60 protein
art_RS17565	COG3103	Sh3 type 3 domain protein
art_RS17565	COG1388	LysM domain
art_RS17595	COG0477	Major facilitator Superfamily
art_RS17610	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
art_RS17620	COG1126	abc transporter atp-binding protein
art_RS17625	COG0765	amino acid transport
art_RS17630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
art_RS17635	COG1132	(ABC) transporter
art_RS17645	COG2814	Major facilitator Superfamily
art_RS17650	COG1228	amidohydrolase
art_RS17680	COG1742	UPF0060 membrane protein
art_RS17690	COG2962	Rard protein
art_RS17705	COG0483	inositol monophosphate 1-phosphatase activity
art_RS17720	COG0045	succinate-CoA ligase (ADP-forming) activity
art_RS17745	COG2814	Major facilitator Superfamily
art_RS17750	COG0656	L-ascorbic acid biosynthetic process
art_RS17755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
art_RS17775	COG0508	dehydrogenase complex catalyzes the overall conversion of
art_RS17795	COG1396	sequence-specific DNA binding
art_RS17805	COG3250	beta-galactosidase activity
art_RS17825	COG0028	Belongs to the TPP enzyme family
art_RS17830	COG0326	Molecular chaperone. Has ATPase activity
art_RS17890	COG1090	epimerase
art_RS17905	COG2186	Transcriptional regulator
art_RS17915	COG1027	Aspartate ammonia-lyase
art_RS17930	COG2186	Transcriptional regulator
art_RS17940	COG2376	Dihydroxyacetone kinase
art_RS17945	COG0698	ribose 5-phosphate isomerase
art_RS17950	COG1250	3-hydroxyacyl-CoA dehydrogenase
art_RS17955	COG1028	Short-chain dehydrogenase reductase Sdr
art_RS17960	COG2271	Major facilitator Superfamily
art_RS17965	COG0149	triose-phosphate isomerase activity
art_RS17975	COG2610	gluconate transmembrane transporter activity
art_RS17980	COG2084	Dehydrogenase
art_RS17990	COG2186	Transcriptional regulator
art_RS18010	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
art_RS18050	COG0747	negative chemotaxis
art_RS18065	COG1070	Carbohydrate kinase
art_RS18070	COG2115	Belongs to the xylose isomerase family
art_RS18080	COG2017	converts alpha-aldose to the beta-anomer
art_RS18085	COG0659	secondary active sulfate transmembrane transporter activity
art_RS18140	COG3634	alkyl hydroperoxide reductase activity
art_RS18170	COG1960	acyl-CoA dehydrogenase activity
art_RS18180	COG2026	Addiction module toxin, RelE StbE family
art_RS18185	COG2161	toxin-antitoxin pair type II binding
art_RS18200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
art_RS18200	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
art_RS18210	COG1278	Cold shock
art_RS18235	COG0477	Major facilitator Superfamily
art_RS18250	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
art_RS18255	COG1472	Belongs to the glycosyl hydrolase 3 family
art_RS18260	COG0138	bifunctional purine biosynthesis protein purh
art_RS18265	COG2826	transposase and inactivated derivatives, IS30 family
art_RS18275	COG2838	Isocitrate dehydrogenase
art_RS18315	COG0395	ABC-type sugar transport system, permease component
art_RS18320	COG1175	transmembrane transport
art_RS18325	COG1653	transport
art_RS18330	COG1940	carbohydrate kinase activity
art_RS18340	COG0667	Aldo Keto reductase
art_RS18350	COG2855	membrane
art_RS18360	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
art_RS18365	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
art_RS18385	COG2197	response regulator
art_RS18410	COG0180	Tryptophanyl-tRNA synthetase
art_RS18430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
art_RS18445	COG2009	succinate dehydrogenase
art_RS18450	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
art_RS18450	COG0662	Cupin 2, conserved barrel domain protein
art_RS18455	COG1473	amidohydrolase
art_RS18455	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
art_RS18460	COG1744	ABC transporter substrate-binding protein PnrA-like
art_RS18465	COG3845	ABC transporter
art_RS18470	COG4603	Belongs to the binding-protein-dependent transport system permease family
art_RS18475	COG1079	Belongs to the binding-protein-dependent transport system permease family
art_RS18500	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
art_RS18515	COG0148	phosphopyruvate hydratase activity
art_RS18565	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
art_RS18575	COG1349	DNA-binding transcription factor activity
art_RS18580	COG2017	converts alpha-aldose to the beta-anomer
art_RS18590	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
art_RS18595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
art_RS18605	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
art_RS18615	COG1331	Highly conserved protein containing a thioredoxin domain
art_RS18625	COG1136	(ABC) transporter
art_RS18625	COG0577	efflux transmembrane transporter activity
art_RS18645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
art_RS18655	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
art_RS18670	COG4565	transcriptional regulatory protein
art_RS18675	COG3290	protein histidine kinase activity
art_RS18680	COG2851	Citrate transporter
art_RS18705	COG0114	fumarate hydratase activity
art_RS18710	COG0288	reversible hydration of carbon dioxide
art_RS18720	COG1494	fructose-1,6-bisphosphatase
art_RS18730	COG1482	cell wall glycoprotein biosynthetic process
art_RS18790	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
art_RS18795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
art_RS18805	COG1376	ErfK ybiS ycfS ynhG family protein
art_RS18835	COG3206	protein involved in exopolysaccharide biosynthesis
art_RS18835	COG0489	protein tyrosine kinase activity
art_RS18845	COG0681	Belongs to the peptidase S26 family
art_RS18880	COG0714	Associated with various cellular activities
art_RS18885	COG0084	hydrolase, TatD family'
art_RS18890	COG3583	domain protein
art_RS18895	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
art_RS18900	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
art_RS18905	COG0488	(ABC) transporter
art_RS18925	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
art_RS18940	COG0193	aminoacyl-tRNA hydrolase activity
art_RS18955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
art_RS18960	COG0673	inositol 2-dehydrogenase activity
art_RS18965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
art_RS18970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
art_RS18985	COG2244	polysaccharide biosynthetic process
art_RS18995	COG0438	transferase activity, transferring glycosyl groups
art_RS19030	COG0579	oxidoreductase
art_RS19135	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
art_RS19205	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
art_RS19230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
art_RS19245	COG0733	neurotransmitter:sodium symporter activity
art_RS19250	COG0477	Major facilitator Superfamily
art_RS19255	COG4770	biotin carboxylase activity
art_RS19270	COG0424	maF-like protein
art_RS19310	COG2409	Drug exporters of the RND superfamily
art_RS19335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
art_RS19365	COG2197	response regulator
art_RS19380	COG0714	Associated with various cellular activities
art_RS19390	COG1305	Transglutaminase-like
art_RS19400	COG0631	protein serine/threonine phosphatase activity
art_RS19420	COG1674	ftsk spoiiie
art_RS19430	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
art_RS19450	COG4585	Histidine kinase
art_RS19455	COG2197	response regulator
art_RS19465	COG0366	Alpha amylase catalytic
art_RS19470	COG0395	ABC-type sugar transport system, permease component
art_RS19475	COG1175	transmembrane transport
art_RS19485	COG1940	carbohydrate kinase activity
art_RS19485	COG1846	Transcriptional regulator
art_RS19490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
art_RS19505	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
art_RS19510	COG0154	amidase activity
art_RS19515	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
art_RS19530	COG4209	transmembrane transport
art_RS19535	COG0395	ABC-type sugar transport system, permease component
art_RS19550	COG0673	inositol 2-dehydrogenase activity
art_RS19560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
art_RS19575	COG3579	cysteine-type endopeptidase activity
art_RS19585	COG0494	nUDIX hydrolase
art_RS19590	COG1051	belongs to the nudix hydrolase family
art_RS19605	COG1131	(ABC) transporter
art_RS19625	COG1063	alcohol dehydrogenase
art_RS19630	COG0156	8-amino-7-oxononanoate synthase activity
art_RS19645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
art_RS19660	COG1228	amidohydrolase
art_RS19690	COG0588	phosphoglycerate mutase activity
art_RS19705	COG2183	response to ionizing radiation
art_RS19710	COG2873	o-acetylhomoserine
art_RS19715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
art_RS19725	COG2755	lipolytic protein G-D-S-L family
art_RS19745	COG1695	Transcriptional regulator
art_RS19765	COG0423	glycine-tRNA ligase activity
art_RS19795	COG3424	synthase
art_RS19800	COG2239	Acts as a magnesium transporter
art_RS19805	COG1309	transcriptional regulator
art_RS19810	COG1511	domain protein
art_RS19830	COG0358	DNA primase activity
art_RS19845	COG2814	Major facilitator Superfamily
art_RS19865	COG0297	glycogen (starch) synthase activity
art_RS19875	COG1960	acyl-CoA dehydrogenase activity
art_RS19885	COG0052	Belongs to the universal ribosomal protein uS2 family
art_RS19890	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
art_RS19895	COG0528	UMP kinase activity
art_RS19900	COG0233	cytoplasmic translational termination
art_RS19915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
art_RS19930	COG3275	phosphorelay sensor kinase activity
art_RS19940	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
art_RS19945	COG1522	sequence-specific DNA binding
art_RS19955	COG0022	dehydrogenase e1 component
art_RS19960	COG0508	dehydrogenase complex catalyzes the overall conversion of
art_RS19975	COG1309	transcriptional regulator
art_RS19980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
art_RS19990	COG1960	acyl-CoA dehydrogenase activity
art_RS20030	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
art_RS20035	COG0750	zinc metalloprotease
art_RS20055	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
art_RS20065	COG0446	pyridine nucleotide-disulphide oxidoreductase
art_RS20065	COG1902	pentaerythritol trinitrate reductase activity
art_RS20085	COG0442	prolyl-tRNA aminoacylation
art_RS20110	COG0779	Required for maturation of 30S ribosomal subunits
art_RS20125	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
art_RS20130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
art_RS20135	COG1960	acyl-CoA dehydrogenase activity
art_RS20145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
art_RS20170	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
art_RS20175	COG1185	polyribonucleotide nucleotidyltransferase activity
art_RS20180	COG0612	Peptidase, M16
art_RS20220	COG0521	Mo-molybdopterin cofactor biosynthetic process
art_RS20230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
art_RS20245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
art_RS20250	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
art_RS20255	COG1674	ftsk spoiiie
art_RS20265	COG1058	Belongs to the CinA family
art_RS20265	COG1546	Belongs to the CinA family
art_RS20270	COG1396	sequence-specific DNA binding
art_RS20275	COG1846	Transcriptional regulator
art_RS20285	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
art_RS20290	COG2137	regulation of response to DNA damage stimulus
art_RS20300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
art_RS20305	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
art_RS20310	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
art_RS20315	COG2813	Specifically methylates the guanine in position
art_RS20320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
art_RS20335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
art_RS20345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
art_RS20350	COG0131	Imidazoleglycerol-phosphate dehydratase
art_RS20355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
art_RS20360	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
art_RS20380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
art_RS20385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
art_RS20390	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
art_RS20405	COG2814	Major facilitator Superfamily
art_RS20425	COG0318	PFAM AMP-dependent synthetase and ligase
art_RS20450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
art_RS20455	COG0072	phenylalanine-tRNA ligase activity
art_RS20455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
art_RS20510	COG1295	ribonuclease BN
art_RS20520	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
art_RS20525	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
art_RS20530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
art_RS20535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
art_RS20540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
art_RS20545	COG1438	arginine binding
art_RS20550	COG0006	proline dipeptidase activity
art_RS20555	COG0137	argininosuccinate synthase activity
art_RS20560	COG0165	Argininosuccinate lyase
art_RS20590	COG1063	alcohol dehydrogenase
art_RS20605	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
art_RS20615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
art_RS20640	COG1309	transcriptional regulator
art_RS20650	COG3119	arylsulfatase activity
art_RS20685	COG0305	Participates in initiation and elongation during chromosome replication
art_RS20715	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
art_RS20815	COG0456	acetyltransferase
art_RS20815	COG0454	-acetyltransferase
art_RS20820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
art_RS20835	COG0629	single-stranded DNA binding
art_RS20890	COG0463	Glycosyl transferase, family 2
art_RS20895	COG2340	Cysteine-rich secretory protein family
art_RS20985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
art_RS21060	COG3012	SEC-C Motif Domain Protein
art_RS21085	COG0791	NLP P60 protein
art_RS21195	COG0561	phosphatase activity
art_RS21245	COG3328	transposase activity
art_RS21260	COG0739	heme binding
art_RS21285	COG4585	Histidine kinase
art_RS21290	COG0586	Pfam SNARE associated Golgi protein
art_RS21340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
art_RS21340	COG1648	precorrin-2 dehydrogenase activity