locus-tag	class	description
C3B78_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C3B78_RS00010	COG0592	DNA-directed DNA polymerase activity
C3B78_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C3B78_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C3B78_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C3B78_RS00030	COG0187	DNA topoisomerase II activity
C3B78_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C3B78_RS00040	COG3266	domain, Protein
C3B78_RS00060	COG1215	transferase activity, transferring glycosyl groups
C3B78_RS00075	COG0705	Rhomboid family
C3B78_RS00080	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C3B78_RS00085	COG2818	Glycosylase
C3B78_RS00095	COG3764	Sortase (surface protein transpeptidase)
C3B78_RS00105	COG0515	serine threonine protein kinase
C3B78_RS00110	COG0515	serine threonine protein kinase
C3B78_RS00130	COG1716	ATPase activity
C3B78_RS00135	COG1716	ATPase activity
C3B78_RS00160	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3B78_RS00175	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3B78_RS00200	COG1472	Belongs to the glycosyl hydrolase 3 family
C3B78_RS00250	COG1175	transmembrane transport
C3B78_RS00260	COG3507	Belongs to the glycosyl hydrolase 43 family
C3B78_RS00275	COG0673	inositol 2-dehydrogenase activity
C3B78_RS00315	COG1175	transmembrane transport
C3B78_RS00320	COG0395	ABC-type sugar transport system, permease component
C3B78_RS00340	COG0346	lactoylglutathione lyase activity
C3B78_RS00380	COG0277	FAD linked oxidase domain protein
C3B78_RS00385	COG0154	amidase activity
C3B78_RS00390	COG2957	Belongs to the agmatine deiminase family
C3B78_RS00400	COG1621	beta-fructofuranosidase activity
C3B78_RS00420	COG3706	GGDEF domain
C3B78_RS00470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C3B78_RS00525	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C3B78_RS00560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C3B78_RS00595	COG0673	inositol 2-dehydrogenase activity
C3B78_RS00605	COG1175	transmembrane transport
C3B78_RS00610	COG1653	transport
C3B78_RS00640	COG0477	Major facilitator Superfamily
C3B78_RS00645	COG1063	alcohol dehydrogenase
C3B78_RS00660	COG0246	Mannitol dehydrogenase
C3B78_RS00665	COG0800	Aldolase
C3B78_RS00685	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C3B78_RS00700	COG0464	growth
C3B78_RS00710	COG1760	l-serine dehydratase
C3B78_RS00735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C3B78_RS00740	COG1802	Transcriptional regulator
C3B78_RS00745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3B78_RS00750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3B78_RS00755	COG0477	Major facilitator Superfamily
C3B78_RS00760	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C3B78_RS00775	COG0395	ABC-type sugar transport system, permease component
C3B78_RS00780	COG1175	transmembrane transport
C3B78_RS00795	COG1621	beta-fructofuranosidase activity
C3B78_RS00820	COG2186	Transcriptional regulator
C3B78_RS00825	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C3B78_RS00830	COG0477	Major facilitator Superfamily
C3B78_RS00835	COG1984	allophanate hydrolase subunit 2
C3B78_RS00840	COG4770	biotin carboxylase activity
C3B78_RS00845	COG0583	DNA-binding transcription factor activity
C3B78_RS00890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3B78_RS00900	COG0477	Major facilitator Superfamily
C3B78_RS00915	COG0561	phosphatase activity
C3B78_RS00940	COG2199	diguanylate cyclase activity
C3B78_RS00940	COG2200	EAL domain
C3B78_RS00950	COG5002	protein histidine kinase activity
C3B78_RS00955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C3B78_RS00965	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS00970	COG1929	Belongs to the glycerate kinase type-1 family
C3B78_RS00985	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS01010	COG2233	PERMEase
C3B78_RS01015	COG0778	Nitroreductase
C3B78_RS01040	COG0277	FAD linked oxidase domain protein
C3B78_RS01045	COG2186	Transcriptional regulator
C3B78_RS01055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C3B78_RS01065	COG5416	Lipopolysaccharide assembly protein A domain
C3B78_RS01080	COG0154	amidase activity
C3B78_RS01085	COG0425	Belongs to the sulfur carrier protein TusA family
C3B78_RS01085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C3B78_RS01100	COG1597	lipid kinase activity
C3B78_RS01105	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C3B78_RS01115	COG0561	phosphatase activity
C3B78_RS01130	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C3B78_RS01165	COG0037	tRNA processing
C3B78_RS01175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3B78_RS01180	COG0302	gtp cyclohydrolase
C3B78_RS01185	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C3B78_RS01190	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C3B78_RS01220	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C3B78_RS01255	COG0366	Alpha amylase catalytic
C3B78_RS01265	COG1175	transmembrane transport
C3B78_RS01270	COG3833	ABC-type maltose transport systems, permease component
C3B78_RS01280	COG0693	protein deglycase activity
C3B78_RS01285	COG2814	Major facilitator Superfamily
C3B78_RS01295	COG1309	transcriptional regulator
C3B78_RS01310	COG3665	Urea carboxylase-associated protein
C3B78_RS01330	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C3B78_RS01350	COG0823	Involved in the tonB-independent uptake of proteins
C3B78_RS01350	COG1506	peptidase
C3B78_RS01355	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C3B78_RS01360	COG2376	Dihydroxyacetone kinase
C3B78_RS01365	COG1461	Dihydroxyacetone kinase
C3B78_RS01370	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C3B78_RS01395	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C3B78_RS01405	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C3B78_RS01440	COG3711	transcriptional antiterminator
C3B78_RS01450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C3B78_RS01465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C3B78_RS01480	COG0306	phosphate transporter
C3B78_RS01500	COG0202	RNA polymerase activity
C3B78_RS01505	COG2151	metal-sulfur cluster biosynthetic enzyme
C3B78_RS01515	COG2193	ferroxidase activity
C3B78_RS01520	COG1609	Transcriptional regulator
C3B78_RS01535	COG1595	DNA-templated transcription, initiation
C3B78_RS01560	COG2160	L-arabinose isomerase activity
C3B78_RS01580	COG1609	Transcriptional regulator
C3B78_RS01585	COG1335	isochorismatase
C3B78_RS01590	COG0831	urea catabolic process
C3B78_RS01595	COG0832	Belongs to the urease beta subunit family
C3B78_RS01600	COG0804	urea catabolic process
C3B78_RS01605	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C3B78_RS01610	COG0830	nickel cation binding
C3B78_RS01615	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C3B78_RS01620	COG0829	nickel cation binding
C3B78_RS01625	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C3B78_RS01645	COG3958	Transketolase
C3B78_RS01650	COG3959	Transketolase, thiamine diphosphate binding domain
C3B78_RS01655	COG0477	Major facilitator Superfamily
C3B78_RS01665	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS01670	COG2376	Dihydroxyacetone kinase
C3B78_RS01675	COG0698	ribose 5-phosphate isomerase
C3B78_RS01690	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS01715	COG0129	dihydroxy-acid dehydratase activity
C3B78_RS01735	COG1175	transmembrane transport
C3B78_RS01740	COG0395	ABC-type sugar transport system, permease component
C3B78_RS01745	COG4948	Mandelate Racemase Muconate Lactonizing
C3B78_RS01750	COG0800	Aldolase
C3B78_RS01755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3B78_RS01760	COG4948	Mandelate Racemase Muconate Lactonizing
C3B78_RS01775	COG0697	spore germination
C3B78_RS01780	COG0667	Aldo Keto reductase
C3B78_RS01805	COG2890	protein-(glutamine-N5) methyltransferase activity
C3B78_RS01835	COG0667	Aldo Keto reductase
C3B78_RS01840	COG0656	L-ascorbic acid biosynthetic process
C3B78_RS01855	COG3360	Dodecin
C3B78_RS01870	COG2084	Dehydrogenase
C3B78_RS01900	COG0076	glutamate decarboxylase activity
C3B78_RS01905	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C3B78_RS01920	COG0300	oxidoreductase activity
C3B78_RS01930	COG0477	Major facilitator Superfamily
C3B78_RS01945	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C3B78_RS01960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3B78_RS01960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3B78_RS01960	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3B78_RS02005	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C3B78_RS02010	COG2733	membrane
C3B78_RS02060	COG4122	O-methyltransferase activity
C3B78_RS02065	COG0783	Belongs to the Dps family
C3B78_RS02120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3B78_RS02125	COG1191	sigma factor activity
C3B78_RS02130	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C3B78_RS02135	COG0859	PFAM glycosyl transferase family 9
C3B78_RS02145	COG0297	glycogen (starch) synthase activity
C3B78_RS02150	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C3B78_RS02155	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C3B78_RS02155	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C3B78_RS02160	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS02165	COG1012	belongs to the aldehyde dehydrogenase family
C3B78_RS02170	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C3B78_RS02170	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C3B78_RS02190	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS02200	COG1733	regulation of RNA biosynthetic process
C3B78_RS02205	COG0702	epimerase
C3B78_RS02215	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C3B78_RS02245	COG0589	response to stress
C3B78_RS02265	COG3290	protein histidine kinase activity
C3B78_RS02275	COG0010	Belongs to the arginase family
C3B78_RS02285	COG2252	PERMEase
C3B78_RS02305	COG0574	Belongs to the PEP-utilizing enzyme family
C3B78_RS02305	COG3848	Pyruvate phosphate dikinase
C3B78_RS02350	COG1796	DNA polymerase
C3B78_RS02350	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C3B78_RS02395	COG0366	Alpha amylase catalytic
C3B78_RS02420	COG1609	Transcriptional regulator
C3B78_RS02465	COG1960	acyl-CoA dehydrogenase activity
C3B78_RS02470	COG0789	Transcriptional regulator
C3B78_RS02480	COG1278	Cold shock
C3B78_RS02490	COG4585	Histidine kinase
C3B78_RS02500	COG0666	response to abiotic stimulus
C3B78_RS02515	COG2031	fatty acid transporter
C3B78_RS02520	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C3B78_RS02535	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C3B78_RS02585	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C3B78_RS02605	COG1832	CoA-binding protein
C3B78_RS02615	COG2315	Protein conserved in bacteria
C3B78_RS02640	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3B78_RS02645	COG0047	phosphoribosylformylglycinamidine synthase activity
C3B78_RS02680	COG1846	Transcriptional regulator
C3B78_RS02700	COG1131	(ABC) transporter
C3B78_RS02715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C3B78_RS02745	COG0741	lytic transglycosylase activity
C3B78_RS02745	COG0739	heme binding
C3B78_RS02745	COG1196	nuclear chromosome segregation
C3B78_RS02750	COG0386	Belongs to the glutathione peroxidase family
C3B78_RS02755	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C3B78_RS02760	COG0438	transferase activity, transferring glycosyl groups
C3B78_RS02780	COG1309	transcriptional regulator
C3B78_RS02790	COG0438	transferase activity, transferring glycosyl groups
C3B78_RS02810	COG0673	inositol 2-dehydrogenase activity
C3B78_RS02815	COG0673	inositol 2-dehydrogenase activity
C3B78_RS02825	COG1940	carbohydrate kinase activity
C3B78_RS02845	COG0673	inositol 2-dehydrogenase activity
C3B78_RS02855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C3B78_RS02865	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C3B78_RS02875	COG1476	TRANSCRIPTIONal
C3B78_RS02885	COG2205	protein histidine kinase activity
C3B78_RS02890	COG0745	RESPONSE REGULATOR receiver
C3B78_RS02895	COG0477	Major facilitator Superfamily
C3B78_RS02905	COG0351	phosphomethylpyrimidine kinase
C3B78_RS02915	COG0343	queuine tRNA-ribosyltransferase activity
C3B78_RS02945	COG3842	ATPase activity
C3B78_RS02970	COG1960	acyl-CoA dehydrogenase activity
C3B78_RS02985	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C3B78_RS03010	COG0564	pseudouridine synthase activity
C3B78_RS03035	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C3B78_RS03040	COG1201	RNA secondary structure unwinding
C3B78_RS03045	COG0723	plastoquinol--plastocyanin reductase activity
C3B78_RS03045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3B78_RS03075	COG1609	Transcriptional regulator
C3B78_RS03085	COG1175	transmembrane transport
C3B78_RS03090	COG0395	ABC-type sugar transport system, permease component
C3B78_RS03100	COG0673	inositol 2-dehydrogenase activity
C3B78_RS03110	COG1904	glucuronate isomerase
C3B78_RS03115	COG0246	Mannitol dehydrogenase
C3B78_RS03120	COG4948	Mandelate Racemase Muconate Lactonizing
C3B78_RS03130	COG0028	Belongs to the TPP enzyme family
C3B78_RS03140	COG2066	Belongs to the glutaminase family
C3B78_RS03145	COG3835	regulator
C3B78_RS03170	COG0438	transferase activity, transferring glycosyl groups
C3B78_RS03180	COG0671	phosphoesterase, PA-phosphatase related
C3B78_RS03185	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C3B78_RS03200	COG2205	protein histidine kinase activity
C3B78_RS03205	COG0745	RESPONSE REGULATOR receiver
C3B78_RS03215	COG2062	phosphohistidine phosphatase, SixA
C3B78_RS03225	COG1309	transcriptional regulator
C3B78_RS03230	COG1511	domain protein
C3B78_RS03250	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C3B78_RS03255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C3B78_RS03255	COG1017	nitric oxide dioxygenase activity
C3B78_RS03270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3B78_RS03275	COG0514	ATP-dependent DNA helicase (RecQ)
C3B78_RS03280	COG0477	Major facilitator Superfamily
C3B78_RS03295	COG1505	serine-type exopeptidase activity
C3B78_RS03310	COG0604	alcohol dehydrogenase
C3B78_RS03325	COG1966	Carbon starvation protein
C3B78_RS03345	COG0656	L-ascorbic acid biosynthetic process
C3B78_RS03365	COG3540	Alkaline phosphatase
C3B78_RS03390	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C3B78_RS03395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C3B78_RS03415	COG0588	phosphoglycerate mutase activity
C3B78_RS03425	COG5002	protein histidine kinase activity
C3B78_RS03445	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C3B78_RS03450	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C3B78_RS03455	COG0215	cysteine-tRNA ligase activity
C3B78_RS03480	COG0028	Belongs to the TPP enzyme family
C3B78_RS03490	COG0366	Alpha amylase catalytic
C3B78_RS03500	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C3B78_RS03525	COG0277	FAD linked oxidase domain protein
C3B78_RS03535	COG3842	ATPase activity
C3B78_RS03695	COG0783	Belongs to the Dps family
C3B78_RS03700	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3B78_RS03700	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3B78_RS03705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C3B78_RS03715	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C3B78_RS03740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C3B78_RS03755	COG1278	Cold shock
C3B78_RS03765	COG0459	protein refolding
C3B78_RS03770	COG0328	RNA-DNA hybrid ribonuclease activity
C3B78_RS03785	COG0745	RESPONSE REGULATOR receiver
C3B78_RS03790	COG1061	Type III restriction enzyme res subunit
C3B78_RS03805	COG1278	Cold shock
C3B78_RS03825	COG0739	heme binding
C3B78_RS03830	COG3103	Sh3 type 3 domain protein
C3B78_RS03830	COG1388	LysM domain
C3B78_RS03830	COG0791	NLP P60 protein
C3B78_RS03850	COG0303	'Molybdopterin
C3B78_RS03855	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C3B78_RS03875	COG0488	(ABC) transporter
C3B78_RS03880	COG1132	(ABC) transporter
C3B78_RS03885	COG0494	nUDIX hydrolase
C3B78_RS03910	COG0483	inositol monophosphate 1-phosphatase activity
C3B78_RS03925	COG0045	succinate-CoA ligase (ADP-forming) activity
C3B78_RS03940	COG0640	Transcriptional regulator
C3B78_RS03945	COG1942	4-Oxalocrotonate Tautomerase
C3B78_RS03950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3B78_RS03960	COG3962	Belongs to the TPP enzyme family
C3B78_RS03970	COG1082	Xylose isomerase domain protein TIM barrel
C3B78_RS03975	COG0673	inositol 2-dehydrogenase activity
C3B78_RS03980	COG1082	Xylose isomerase domain protein TIM barrel
C3B78_RS03985	COG2814	Major facilitator Superfamily
C3B78_RS04005	COG1609	Transcriptional regulator
C3B78_RS04015	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3B78_RS04025	COG0673	inositol 2-dehydrogenase activity
C3B78_RS04030	COG0673	inositol 2-dehydrogenase activity
C3B78_RS04040	COG0673	inositol 2-dehydrogenase activity
C3B78_RS04045	COG1609	Transcriptional regulator
C3B78_RS04050	COG3718	enzyme involved in inositol metabolism
C3B78_RS04060	COG2814	Major facilitator Superfamily
C3B78_RS04090	COG1396	sequence-specific DNA binding
C3B78_RS04100	COG0028	Belongs to the TPP enzyme family
C3B78_RS04125	COG1401	restriction endodeoxyribonuclease activity
C3B78_RS04135	COG5002	protein histidine kinase activity
C3B78_RS04140	COG0745	RESPONSE REGULATOR receiver
C3B78_RS04165	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C3B78_RS04185	COG1902	pentaerythritol trinitrate reductase activity
C3B78_RS04220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3B78_RS04235	COG3583	domain protein
C3B78_RS04245	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C3B78_RS04250	COG3103	Sh3 type 3 domain protein
C3B78_RS04250	COG0366	Alpha amylase catalytic
C3B78_RS04255	COG1254	Belongs to the acylphosphatase family
C3B78_RS04285	COG1063	alcohol dehydrogenase
C3B78_RS04300	COG0477	Major facilitator Superfamily
C3B78_RS04350	COG1012	belongs to the aldehyde dehydrogenase family
C3B78_RS04355	COG0395	ABC-type sugar transport system, permease component
C3B78_RS04360	COG1175	transmembrane transport
C3B78_RS04370	COG3684	Belongs to the aldolase LacD family
C3B78_RS04380	COG0673	inositol 2-dehydrogenase activity
C3B78_RS04395	COG2814	Major facilitator Superfamily
C3B78_RS04420	COG1063	alcohol dehydrogenase
C3B78_RS04425	COG0395	ABC-type sugar transport system, permease component
C3B78_RS04490	COG0596	Alpha beta hydrolase
C3B78_RS04495	COG1253	flavin adenine dinucleotide binding
C3B78_RS04510	COG0385	Bile acid
C3B78_RS04570	COG1879	ABC-type sugar transport system periplasmic component
C3B78_RS04575	COG1129	ABC transporter
C3B78_RS04580	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3B78_RS04590	COG1070	Carbohydrate kinase
C3B78_RS04595	COG0647	UMP catabolic process
C3B78_RS04600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C3B78_RS04605	COG0022	dehydrogenase e1 component
C3B78_RS04610	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3B78_RS04615	COG0191	fructose-bisphosphate aldolase activity
C3B78_RS04620	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3B78_RS04625	COG2195	Cleaves the N-terminal amino acid of tripeptides
C3B78_RS04630	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3B78_RS04635	COG1129	ABC transporter
C3B78_RS04640	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3B78_RS04645	COG1879	ABC-type sugar transport system periplasmic component
C3B78_RS04655	COG3246	L-lysine catabolic process to acetate
C3B78_RS04665	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C3B78_RS04670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C3B78_RS04680	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C3B78_RS04685	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C3B78_RS04715	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C3B78_RS04725	COG0477	Major facilitator Superfamily
C3B78_RS04740	COG0028	Belongs to the TPP enzyme family
C3B78_RS04750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3B78_RS04755	COG1113	amino acid transport
C3B78_RS04760	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C3B78_RS04770	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3B78_RS04790	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3B78_RS04795	COG1116	anion transmembrane transporter activity
C3B78_RS04805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3B78_RS04825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3B78_RS04830	COG0531	amino acid
C3B78_RS04835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3B78_RS04845	COG1074	ATP-dependent DNA helicase activity
C3B78_RS04865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C3B78_RS04920	COG1401	restriction endodeoxyribonuclease activity
C3B78_RS04965	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C3B78_RS04965	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C3B78_RS04995	COG4942	peptidase
C3B78_RS05010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C3B78_RS05030	COG5001	Diguanylate cyclase
C3B78_RS05040	COG2350	Protein conserved in bacteria
C3B78_RS05045	COG1349	DNA-binding transcription factor activity
C3B78_RS05050	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C3B78_RS05055	COG3395	kinase activity
C3B78_RS05075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3B78_RS05080	COG0477	Major facilitator Superfamily
C3B78_RS05100	COG1609	Transcriptional regulator
C3B78_RS05115	COG1129	ABC transporter
C3B78_RS05120	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3B78_RS05125	COG1082	Xylose isomerase domain protein TIM barrel
C3B78_RS05135	COG2186	Transcriptional regulator
C3B78_RS05180	COG2072	flavoprotein involved in K transport
C3B78_RS05185	COG1278	Cold shock
C3B78_RS05200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C3B78_RS05215	COG3265	gluconokinase activity
C3B78_RS05220	COG2610	gluconate transmembrane transporter activity
C3B78_RS05230	COG3540	Alkaline phosphatase
C3B78_RS05260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3B78_RS05295	COG3300	MHYT domain
C3B78_RS05295	COG5001	Diguanylate cyclase
C3B78_RS05300	COG2261	transglycosylase associated protein
C3B78_RS05305	COG0561	phosphatase activity
C3B78_RS05310	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C3B78_RS05315	COG0438	transferase activity, transferring glycosyl groups
C3B78_RS05315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3B78_RS05320	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
C3B78_RS05350	COG0477	Major facilitator Superfamily
C3B78_RS05355	COG0138	bifunctional purine biosynthesis protein purh
C3B78_RS05370	COG2838	Isocitrate dehydrogenase
C3B78_RS05425	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3B78_RS05450	COG0531	amino acid
C3B78_RS05480	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C3B78_RS05510	COG0180	Tryptophanyl-tRNA synthetase
C3B78_RS05530	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C3B78_RS05545	COG2009	succinate dehydrogenase
C3B78_RS05555	COG1473	amidohydrolase
C3B78_RS05555	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C3B78_RS05560	COG1846	Transcriptional regulator
C3B78_RS05565	COG1764	response to oxidative stress
C3B78_RS05570	COG2130	NADP-dependent
C3B78_RS05575	COG1744	ABC transporter substrate-binding protein PnrA-like
C3B78_RS05580	COG3845	ABC transporter
C3B78_RS05585	COG4603	Belongs to the binding-protein-dependent transport system permease family
C3B78_RS05590	COG1079	Belongs to the binding-protein-dependent transport system permease family
C3B78_RS05605	COG0586	Pfam SNARE associated Golgi protein
C3B78_RS05610	COG0586	Pfam SNARE associated Golgi protein
C3B78_RS05615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C3B78_RS05620	COG3956	TIGRFAM MazG family protein
C3B78_RS05625	COG0148	phosphopyruvate hydratase activity
C3B78_RS05650	COG1252	NADH dehydrogenase
C3B78_RS05690	COG0559	Belongs to the binding-protein-dependent transport system permease family
C3B78_RS05700	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C3B78_RS05710	COG2017	converts alpha-aldose to the beta-anomer
C3B78_RS05720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C3B78_RS05730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3B78_RS05740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C3B78_RS05755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3B78_RS05760	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C3B78_RS05785	COG0114	fumarate hydratase activity
C3B78_RS05790	COG0288	reversible hydration of carbon dioxide
C3B78_RS05800	COG1494	fructose-1,6-bisphosphatase
C3B78_RS05810	COG1482	cell wall glycoprotein biosynthetic process
C3B78_RS05815	COG1316	TRANSCRIPTIONal
C3B78_RS05820	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C3B78_RS05870	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C3B78_RS05875	COG1376	ErfK ybiS ycfS ynhG family protein
C3B78_RS05925	COG0714	Associated with various cellular activities
C3B78_RS05930	COG0084	hydrolase, TatD family'
C3B78_RS05935	COG3583	domain protein
C3B78_RS05940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C3B78_RS05945	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C3B78_RS05950	COG0488	(ABC) transporter
C3B78_RS05955	COG1309	transcriptional regulator
C3B78_RS05965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C3B78_RS05970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C3B78_RS05975	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C3B78_RS05980	COG0193	aminoacyl-tRNA hydrolase activity
C3B78_RS06000	COG0822	iron-sulfur transferase activity
C3B78_RS06015	COG0702	epimerase
C3B78_RS06035	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C3B78_RS06040	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3B78_RS06050	COG1648	precorrin-2 dehydrogenase activity
C3B78_RS06050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C3B78_RS06055	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3B78_RS06065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3B78_RS06090	COG0243	molybdopterin cofactor binding
C3B78_RS06095	COG2223	nitrite transmembrane transporter activity
C3B78_RS06100	COG0477	Major facilitator Superfamily
C3B78_RS06115	COG4770	biotin carboxylase activity
C3B78_RS06120	COG0424	maF-like protein
C3B78_RS06125	COG2409	Drug exporters of the RND superfamily
C3B78_RS06140	COG1823	symporter activity
C3B78_RS06155	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3B78_RS06185	COG0714	Associated with various cellular activities
C3B78_RS06205	COG0631	protein serine/threonine phosphatase activity
C3B78_RS06225	COG1674	ftsk spoiiie
C3B78_RS06235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C3B78_RS06240	COG0483	inositol monophosphate 1-phosphatase activity
C3B78_RS06245	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C3B78_RS06250	COG0251	oxidation-reduction process
C3B78_RS06255	COG4565	transcriptional regulatory protein
C3B78_RS06260	COG3290	protein histidine kinase activity
C3B78_RS06265	COG2851	Citrate transporter
C3B78_RS06270	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3B78_RS06275	COG0154	amidase activity
C3B78_RS06280	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3B78_RS06295	COG1063	alcohol dehydrogenase
C3B78_RS06310	COG1228	amidohydrolase
C3B78_RS06340	COG2873	o-acetylhomoserine
C3B78_RS06345	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C3B78_RS06390	COG0400	carboxylic ester hydrolase activity
C3B78_RS06405	COG0423	glycine-tRNA ligase activity
C3B78_RS06435	COG0358	DNA primase activity
C3B78_RS06460	COG2814	Major facilitator Superfamily
C3B78_RS06520	COG0052	Belongs to the universal ribosomal protein uS2 family
C3B78_RS06525	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C3B78_RS06530	COG0528	UMP kinase activity
C3B78_RS06535	COG0233	cytoplasmic translational termination
C3B78_RS06550	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3B78_RS06565	COG3275	phosphorelay sensor kinase activity
C3B78_RS06575	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3B78_RS06585	COG1522	sequence-specific DNA binding
C3B78_RS06595	COG0022	dehydrogenase e1 component
C3B78_RS06600	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3B78_RS06610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3B78_RS06620	COG1960	acyl-CoA dehydrogenase activity
C3B78_RS06650	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C3B78_RS06655	COG0750	zinc metalloprotease
C3B78_RS06675	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C3B78_RS06680	COG0456	acetyltransferase
C3B78_RS06700	COG0442	prolyl-tRNA aminoacylation
C3B78_RS06730	COG0779	Required for maturation of 30S ribosomal subunits
C3B78_RS06735	COG0195	Participates in both transcription termination and antitermination
C3B78_RS06750	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C3B78_RS06760	COG0590	tRNA wobble adenosine to inosine editing
C3B78_RS06770	COG0436	Aminotransferase
C3B78_RS06775	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C3B78_RS06795	COG3483	tryptophan 2,3-dioxygenase activity
C3B78_RS06805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C3B78_RS06810	COG1185	polyribonucleotide nucleotidyltransferase activity
C3B78_RS06815	COG0612	Peptidase, M16
C3B78_RS06855	COG0521	Mo-molybdopterin cofactor biosynthetic process
C3B78_RS06865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C3B78_RS06890	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C3B78_RS06895	COG1674	ftsk spoiiie
C3B78_RS06905	COG1546	Belongs to the CinA family
C3B78_RS06905	COG1058	Belongs to the CinA family
C3B78_RS06910	COG1396	sequence-specific DNA binding
C3B78_RS06925	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C3B78_RS06930	COG2137	regulation of response to DNA damage stimulus
C3B78_RS06935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3B78_RS06940	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C3B78_RS06945	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C3B78_RS06950	COG2813	Specifically methylates the guanine in position
C3B78_RS06955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C3B78_RS06965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C3B78_RS06975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3B78_RS06980	COG0131	Imidazoleglycerol-phosphate dehydratase
C3B78_RS06985	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C3B78_RS06990	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C3B78_RS07010	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C3B78_RS07015	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C3B78_RS07020	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C3B78_RS07025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3B78_RS07040	COG2814	Major facilitator Superfamily
C3B78_RS07045	COG2816	NAD+ diphosphatase activity
C3B78_RS07065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C3B78_RS07070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3B78_RS07070	COG0072	phenylalanine-tRNA ligase activity
C3B78_RS07095	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C3B78_RS07100	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C3B78_RS07105	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C3B78_RS07110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3B78_RS07115	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C3B78_RS07120	COG1438	arginine binding
C3B78_RS07125	COG0137	argininosuccinate synthase activity
C3B78_RS07130	COG0165	Argininosuccinate lyase
C3B78_RS07135	COG0259	pyridoxamine-phosphate oxidase activity
C3B78_RS07145	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C3B78_RS07145	COG2169	Transcriptional regulator
C3B78_RS07155	COG2094	Belongs to the DNA glycosylase MPG family
C3B78_RS07160	COG3973	AAA domain
C3B78_RS07165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C3B78_RS07190	COG0647	UMP catabolic process
C3B78_RS07205	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C3B78_RS07210	COG0497	DNA recombination
C3B78_RS07215	COG0504	CTP synthase activity
C3B78_RS07220	COG0494	nUDIX hydrolase
C3B78_RS07240	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C3B78_RS07245	COG2079	MmgE PrpD family protein
C3B78_RS07265	COG3290	protein histidine kinase activity
C3B78_RS07270	COG1301	dicarboxylic acid transport
C3B78_RS07280	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C3B78_RS07285	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C3B78_RS07300	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C3B78_RS07310	COG1160	GTP binding
C3B78_RS07320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C3B78_RS07325	COG0509	glycine decarboxylation via glycine cleavage system
C3B78_RS07330	COG1716	ATPase activity
C3B78_RS07350	COG1192	Involved in chromosome partitioning
C3B78_RS07355	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C3B78_RS07365	COG1940	carbohydrate kinase activity
C3B78_RS07390	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C3B78_RS07395	COG0515	serine threonine protein kinase
C3B78_RS07395	COG2815	serine threonine protein kinase
C3B78_RS07400	COG0741	lytic transglycosylase activity
C3B78_RS07410	COG0142	geranyltranstransferase activity
C3B78_RS07420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C3B78_RS07430	COG2001	Belongs to the MraZ family
C3B78_RS07435	COG0275	rRNA processing
C3B78_RS07445	COG0768	penicillin binding
C3B78_RS07450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C3B78_RS07460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3B78_RS07465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C3B78_RS07470	COG0772	Belongs to the SEDS family
C3B78_RS07475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3B78_RS07480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C3B78_RS07490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C3B78_RS07500	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C3B78_RS07505	COG1799	cell septum assembly
C3B78_RS07515	COG3599	regulation of cell shape
C3B78_RS07520	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C3B78_RS07530	COG0587	DNA-directed DNA polymerase activity
C3B78_RS07545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C3B78_RS07550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C3B78_RS07565	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C3B78_RS07570	COG0174	glutamine synthetase
C3B78_RS07575	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C3B78_RS07610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C3B78_RS07615	COG0321	lipoyl(octanoyl) transferase activity
C3B78_RS07625	COG1090	epimerase
C3B78_RS07630	COG0793	Belongs to the peptidase S41A family
C3B78_RS07630	COG4946	Tricorn protease homolog
C3B78_RS07635	COG1764	response to oxidative stress
C3B78_RS07645	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3B78_RS07650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3B78_RS07655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C3B78_RS07675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C3B78_RS07700	COG1271	oxidase subunit
C3B78_RS07705	COG1294	oxidase, subunit
C3B78_RS07710	COG4988	ABC transporter
C3B78_RS07720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C3B78_RS07725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C3B78_RS07725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3B78_RS07740	COG1435	thymidine kinase activity
C3B78_RS07760	COG0756	dUTP diphosphatase activity
C3B78_RS07785	COG0569	domain protein
C3B78_RS07790	COG0531	amino acid
C3B78_RS07795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C3B78_RS07800	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C3B78_RS07805	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C3B78_RS07820	COG0667	Aldo Keto reductase
C3B78_RS07840	COG1122	ATPase activity
C3B78_RS07845	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3B78_RS07845	COG1024	Enoyl-CoA hydratase
C3B78_RS07850	COG0183	Belongs to the thiolase family
C3B78_RS07855	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C3B78_RS07880	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3B78_RS07895	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C3B78_RS07955	COG0242	peptide deformylase activity
C3B78_RS07960	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C3B78_RS07970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C3B78_RS07985	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3B78_RS07985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3B78_RS07995	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C3B78_RS08000	COG0140	phosphoribosyl-ATP diphosphatase activity
C3B78_RS08005	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C3B78_RS08010	COG0107	imidazoleglycerol-phosphate synthase activity
C3B78_RS08020	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C3B78_RS08040	COG0134	indole-3-glycerol-phosphate synthase activity
C3B78_RS08045	COG0133	tryptophan synthase activity
C3B78_RS08050	COG0159	tryptophan synthase activity
C3B78_RS08055	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C3B78_RS08060	COG0070	glutamate synthase
C3B78_RS08060	COG0069	glutamate synthase activity
C3B78_RS08060	COG0067	glutamate synthase
C3B78_RS08245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C3B78_RS08265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3B78_RS08270	COG1879	ABC-type sugar transport system periplasmic component
C3B78_RS08275	COG1129	ABC transporter
C3B78_RS08280	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3B78_RS08295	COG2084	Dehydrogenase
C3B78_RS08310	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C3B78_RS08325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3B78_RS08340	COG3360	Dodecin
C3B78_RS08355	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3B78_RS08360	COG1129	ABC transporter
C3B78_RS08375	COG0473	3-isopropylmalate dehydrogenase activity
C3B78_RS08380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3B78_RS08385	COG1301	dicarboxylic acid transport
C3B78_RS08390	COG4948	Mandelate Racemase Muconate Lactonizing
C3B78_RS08400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3B78_RS08415	COG2814	Major facilitator Superfamily
C3B78_RS08450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C3B78_RS08485	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3B78_RS08490	COG1129	ABC transporter
C3B78_RS08520	COG3387	PFAM Glycoside hydrolase 15-related
C3B78_RS08535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3B78_RS08550	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS08555	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS08560	COG2085	NADP oxidoreductase coenzyme F420-dependent
C3B78_RS08565	COG0183	Belongs to the thiolase family
C3B78_RS08570	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C3B78_RS08575	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS08600	COG0006	proline dipeptidase activity
C3B78_RS08630	COG2072	flavoprotein involved in K transport
C3B78_RS08635	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS08645	COG0494	nUDIX hydrolase
C3B78_RS08660	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C3B78_RS08670	COG0028	Belongs to the TPP enzyme family
C3B78_RS08675	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3B78_RS08685	COG1802	Transcriptional regulator
C3B78_RS08710	COG0477	Major facilitator Superfamily
C3B78_RS08755	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C3B78_RS08760	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3B78_RS08785	COG1012	belongs to the aldehyde dehydrogenase family
C3B78_RS08790	COG0133	tryptophan synthase activity
C3B78_RS08805	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS08810	COG1012	belongs to the aldehyde dehydrogenase family
C3B78_RS08815	COG3284	Transcriptional regulator
C3B78_RS08825	COG0673	inositol 2-dehydrogenase activity
C3B78_RS08830	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS08835	COG0129	dihydroxy-acid dehydratase activity
C3B78_RS08850	COG0673	inositol 2-dehydrogenase activity
C3B78_RS08860	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3B78_RS08870	COG0277	FAD linked oxidase domain protein
C3B78_RS08870	COG0247	lactate metabolic process
C3B78_RS08885	COG1113	amino acid transport
C3B78_RS08915	COG0028	Belongs to the TPP enzyme family
C3B78_RS08920	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C3B78_RS08935	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C3B78_RS08950	COG0022	dehydrogenase e1 component
C3B78_RS08950	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3B78_RS08955	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C3B78_RS08960	COG0673	inositol 2-dehydrogenase activity
C3B78_RS08975	COG3732	PTS system glucitol sorbitol-specific
C3B78_RS08985	COG2390	Transcriptional regulator
C3B78_RS08990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C3B78_RS09035	COG0395	ABC-type sugar transport system, permease component
C3B78_RS09055	COG1609	Transcriptional regulator
C3B78_RS09065	COG1621	beta-fructofuranosidase activity
C3B78_RS09075	COG0395	ABC-type sugar transport system, permease component
C3B78_RS09080	COG4209	transmembrane transport
C3B78_RS09085	COG1609	Transcriptional regulator
C3B78_RS09100	COG3654	unkown
C3B78_RS09125	COG2368	4-hydroxyphenylacetate
C3B78_RS09135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3B78_RS09160	COG0402	S-adenosylhomocysteine deaminase activity
C3B78_RS09175	COG0477	Major facilitator Superfamily
C3B78_RS09185	COG0800	Aldolase
C3B78_RS09195	COG1609	Transcriptional regulator
C3B78_RS09215	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS09220	COG1309	transcriptional regulator
C3B78_RS09230	COG0604	alcohol dehydrogenase
C3B78_RS09230	COG3321	synthase
C3B78_RS09260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3B78_RS09265	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS09275	COG0251	oxidation-reduction process
C3B78_RS09300	COG1802	Transcriptional regulator
C3B78_RS09310	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C3B78_RS09320	COG1126	abc transporter atp-binding protein
C3B78_RS09325	COG0765	amino acid transport
C3B78_RS09340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3B78_RS09345	COG1012	belongs to the aldehyde dehydrogenase family
C3B78_RS09350	COG0473	3-isopropylmalate dehydrogenase activity
C3B78_RS09360	COG1027	Aspartate ammonia-lyase
C3B78_RS09365	COG4172	Belongs to the ABC transporter superfamily
C3B78_RS09370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3B78_RS09375	COG0601	transmembrane transport
C3B78_RS09380	COG0747	negative chemotaxis
C3B78_RS09390	COG0640	Transcriptional regulator
C3B78_RS09400	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C3B78_RS09410	COG4172	Belongs to the ABC transporter superfamily
C3B78_RS09415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3B78_RS09445	COG0745	RESPONSE REGULATOR receiver
C3B78_RS09455	COG0673	inositol 2-dehydrogenase activity
C3B78_RS09465	COG2814	Major facilitator Superfamily
C3B78_RS09495	COG0589	response to stress
C3B78_RS09510	COG2828	Protein conserved in bacteria
C3B78_RS09515	COG0583	DNA-binding transcription factor activity
C3B78_RS09545	COG1737	Transcriptional regulator
C3B78_RS09550	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C3B78_RS09555	COG1175	transmembrane transport
C3B78_RS09560	COG0395	ABC-type sugar transport system, permease component
C3B78_RS09570	COG3842	ATPase activity
C3B78_RS09595	COG3386	PFAM SMP-30 Gluconolaconase
C3B78_RS09600	COG0667	Aldo Keto reductase
C3B78_RS09630	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
C3B78_RS09640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3B78_RS09655	COG1643	Atp-dependent helicase
C3B78_RS09670	COG0009	L-threonylcarbamoyladenylate synthase
C3B78_RS09705	COG2050	protein possibly involved in aromatic compounds catabolism
C3B78_RS09715	COG4552	Acetyltransferase involved in intracellular survival and related
C3B78_RS09720	COG0539	negative regulation of cytoplasmic translation
C3B78_RS09730	COG1739	Uncharacterized protein family UPF0029
C3B78_RS09735	COG0237	dephospho-CoA kinase activity
C3B78_RS09735	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C3B78_RS09740	COG0556	nucleotide-excision repair
C3B78_RS09750	COG0477	Major facilitator Superfamily
C3B78_RS09770	COG4106	trans-aconitate 2-methyltransferase activity
C3B78_RS09790	COG0546	phosphoglycolate phosphatase activity
C3B78_RS09800	COG0322	excinuclease ABC activity
C3B78_RS09805	COG1660	Displays ATPase and GTPase activities
C3B78_RS09810	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C3B78_RS09815	COG1481	regulation of sporulation
C3B78_RS09820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C3B78_RS09825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C3B78_RS09830	COG0126	phosphoglycerate kinase activity
C3B78_RS09835	COG0149	triose-phosphate isomerase activity
C3B78_RS09840	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C3B78_RS09850	COG0363	glucosamine-6-phosphate deaminase activity
C3B78_RS09865	COG0166	Belongs to the GPI family
C3B78_RS09870	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C3B78_RS09880	COG0109	protoheme IX farnesyltransferase activity
C3B78_RS09885	COG1612	heme a metabolic process
C3B78_RS09895	COG1131	(ABC) transporter
C3B78_RS09920	COG0396	ATPase activity
C3B78_RS09925	COG2151	metal-sulfur cluster biosynthetic enzyme
C3B78_RS09940	COG0183	Belongs to the thiolase family
C3B78_RS09950	COG1122	ATPase activity
C3B78_RS09955	COG1268	BioY protein
C3B78_RS09970	COG0488	(ABC) transporter
C3B78_RS10000	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS10005	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS10010	COG3830	Belongs to the UPF0237 family
C3B78_RS10010	COG0560	Phosphoserine phosphatase
C3B78_RS10015	COG1119	ATPase activity
C3B78_RS10030	COG0254	rRNA binding
C3B78_RS10045	COG2855	membrane
C3B78_RS10060	COG1305	Transglutaminase-like
C3B78_RS10075	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C3B78_RS10080	COG0297	glycogen (starch) synthase activity
C3B78_RS10095	COG0183	Belongs to the thiolase family
C3B78_RS10120	COG0435	Glutathione S-transferase
C3B78_RS10165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3B78_RS10185	COG0656	L-ascorbic acid biosynthetic process
C3B78_RS10190	COG1968	undecaprenyl-diphosphatase activity
C3B78_RS10195	COG0215	cysteine-tRNA ligase activity
C3B78_RS10205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3B78_RS10210	COG1994	Peptidase M50
C3B78_RS10210	COG0517	IMP dehydrogenase activity
C3B78_RS10220	COG1222	aaa ATPase
C3B78_RS10225	COG4122	O-methyltransferase activity
C3B78_RS10235	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C3B78_RS10240	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C3B78_RS10245	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C3B78_RS10250	COG0545	Peptidyl-prolyl cis-trans isomerase
C3B78_RS10270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3B78_RS10275	COG0805	protein transport
C3B78_RS10280	COG4581	dead DEAH box helicase
C3B78_RS10285	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C3B78_RS10290	COG1216	Glycosyl transferase, family 2
C3B78_RS10315	COG0242	peptide deformylase activity
C3B78_RS10325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C3B78_RS10335	COG3424	synthase
C3B78_RS10370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C3B78_RS10375	COG1845	cytochrome c oxidase, subunit III
C3B78_RS10380	COG2010	Cytochrome c
C3B78_RS10385	COG0723	plastoquinol--plastocyanin reductase activity
C3B78_RS10390	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C3B78_RS10400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3B78_RS10410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C3B78_RS10415	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C3B78_RS10435	COG0167	dihydroorotate dehydrogenase activity
C3B78_RS10445	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3B78_RS10450	COG1381	Involved in DNA repair and RecF pathway recombination
C3B78_RS10455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3B78_RS10460	COG3590	peptidase
C3B78_RS10465	COG1316	TRANSCRIPTIONal
C3B78_RS10470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C3B78_RS10480	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C3B78_RS10495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C3B78_RS10500	COG0484	heat shock protein binding
C3B78_RS10505	COG1420	regulation of RNA biosynthetic process
C3B78_RS10520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C3B78_RS10525	COG0481	GTPase activity
C3B78_RS10535	COG0268	Binds directly to 16S ribosomal RNA
C3B78_RS10555	COG1307	EDD domain protein, DegV family
C3B78_RS10560	COG0495	leucyl-tRNA aminoacylation
C3B78_RS10585	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C3B78_RS10590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C3B78_RS10595	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C3B78_RS10600	COG2390	Transcriptional regulator
C3B78_RS10605	COG0656	L-ascorbic acid biosynthetic process
C3B78_RS10615	COG0438	transferase activity, transferring glycosyl groups
C3B78_RS10625	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C3B78_RS10635	COG1758	RNA polymerase activity
C3B78_RS10640	COG0194	GDP metabolic process
C3B78_RS10645	COG0194	GDP metabolic process
C3B78_RS10650	COG0284	orotidine-5'-phosphate decarboxylase activity
C3B78_RS10655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C3B78_RS10660	COG0505	Belongs to the CarA family
C3B78_RS10670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3B78_RS10675	COG0540	Belongs to the ATCase OTCase family
C3B78_RS10680	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C3B78_RS10690	COG0149	triose-phosphate isomerase activity
C3B78_RS10695	COG2271	Major facilitator Superfamily
C3B78_RS10700	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS10705	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3B78_RS10710	COG0698	ribose 5-phosphate isomerase
C3B78_RS10715	COG2376	Dihydroxyacetone kinase
C3B78_RS10730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C3B78_RS10735	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C3B78_RS10745	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C3B78_RS10750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C3B78_RS10755	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C3B78_RS10760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C3B78_RS10775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C3B78_RS10790	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C3B78_RS10810	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C3B78_RS10820	COG0124	histidyl-tRNA synthetase
C3B78_RS10825	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C3B78_RS10830	COG1196	nuclear chromosome segregation
C3B78_RS10840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C3B78_RS10845	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3B78_RS10850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3B78_RS10860	COG2255	four-way junction helicase activity
C3B78_RS10865	COG0632	four-way junction helicase activity
C3B78_RS10870	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C3B78_RS10875	COG0217	transcriptional regulatory protein
C3B78_RS10880	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C3B78_RS10885	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C3B78_RS10905	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C3B78_RS10910	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C3B78_RS10920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C3B78_RS10925	COG0587	DNA-directed DNA polymerase activity
C3B78_RS10940	COG0077	Prephenate dehydratase
C3B78_RS10940	COG1605	Chorismate mutase
C3B78_RS10950	COG2135	peptidase activity
C3B78_RS10985	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C3B78_RS10990	COG1695	Transcriptional regulator
C3B78_RS11045	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C3B78_RS11050	COG1234	tRNA 3'-trailer cleavage
C3B78_RS11070	COG0589	response to stress
C3B78_RS11150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C3B78_RS11150	COG0574	Belongs to the PEP-utilizing enzyme family
C3B78_RS11155	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C3B78_RS11165	COG2217	Heavy metal translocating P-type atpase
C3B78_RS11175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C3B78_RS11175	COG0426	domain, Protein
C3B78_RS11240	COG1175	transmembrane transport
C3B78_RS11245	COG0395	ABC-type sugar transport system, permease component
C3B78_RS11250	COG1621	beta-fructofuranosidase activity
C3B78_RS11255	COG0584	glycerophosphoryl diester phosphodiesterase
C3B78_RS11315	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C3B78_RS11325	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C3B78_RS11340	COG2161	toxin-antitoxin pair type II binding
C3B78_RS11415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3B78_RS11420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3B78_RS11425	COG1780	Probably involved in ribonucleotide reductase function
C3B78_RS11435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C3B78_RS11465	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C3B78_RS11495	COG0714	Associated with various cellular activities
C3B78_RS11505	COG0395	ABC-type sugar transport system, permease component
C3B78_RS11510	COG1175	transmembrane transport
C3B78_RS11530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C3B78_RS11545	COG0799	negative regulation of ribosome biogenesis
C3B78_RS11555	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C3B78_RS11565	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C3B78_RS11570	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C3B78_RS11575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C3B78_RS11580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C3B78_RS11585	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C3B78_RS11590	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C3B78_RS11590	COG0351	phosphomethylpyrimidine kinase
C3B78_RS11590	COG0352	thiamine-phosphate diphosphorylase activity
C3B78_RS11595	COG1530	ribonuclease E activity
C3B78_RS11610	COG0105	UTP biosynthetic process
C3B78_RS11620	COG0285	dihydrofolate synthase activity
C3B78_RS11625	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C3B78_RS11640	COG0525	valine-tRNA ligase activity
C3B78_RS11645	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C3B78_RS11650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C3B78_RS11655	COG0740	serine-type endopeptidase activity
C3B78_RS11660	COG0740	serine-type endopeptidase activity
C3B78_RS11665	COG0544	peptidyl-prolyl cis-trans isomerase activity
C3B78_RS11710	COG0668	transmembrane transport
C3B78_RS11725	COG1946	Acyl-CoA thioesterase
C3B78_RS11740	COG0629	single-stranded DNA binding
C3B78_RS11755	COG2115	Belongs to the xylose isomerase family
C3B78_RS11760	COG1070	Carbohydrate kinase
C3B78_RS11765	COG1082	Xylose isomerase domain protein TIM barrel
C3B78_RS11775	COG0673	inositol 2-dehydrogenase activity
C3B78_RS11785	COG2755	lipolytic protein G-D-S-L family
C3B78_RS11785	COG0657	acetylesterase activity
C3B78_RS11790	COG2017	converts alpha-aldose to the beta-anomer
C3B78_RS11815	COG0242	peptide deformylase activity
C3B78_RS11845	COG3022	response to hydroperoxide
C3B78_RS11855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C3B78_RS11860	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3B78_RS11870	COG1045	serine acetyltransferase
C3B78_RS11875	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C3B78_RS11910	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C3B78_RS11925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3B78_RS11930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3B78_RS11935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C3B78_RS11945	COG4974	Belongs to the 'phage' integrase family
C3B78_RS11960	COG0792	nuclease activity
C3B78_RS11970	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C3B78_RS11980	COG0681	Belongs to the peptidase S26 family
C3B78_RS11985	COG0335	large ribosomal subunit rRNA binding
C3B78_RS11990	COG0336	Belongs to the RNA methyltransferase TrmD family
C3B78_RS11995	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C3B78_RS12000	COG1837	Belongs to the UPF0109 family
C3B78_RS12005	COG0228	four-way junction DNA binding
C3B78_RS12015	COG2514	catechol 2,3-dioxygenase activity
C3B78_RS12040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C3B78_RS12055	COG2814	Major facilitator Superfamily
C3B78_RS12065	COG1196	nuclear chromosome segregation
C3B78_RS12070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C3B78_RS12075	COG0571	ribonuclease III activity
C3B78_RS12080	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C3B78_RS12090	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C3B78_RS12105	COG0742	ribosomal rna small subunit methyltransferase
C3B78_RS12115	COG1461	Dihydroxyacetone kinase
C3B78_RS12130	COG1181	Belongs to the D-alanine--D-alanine ligase family
C3B78_RS12135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C3B78_RS12145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C3B78_RS12150	COG0066	3-isopropylmalate dehydratase activity
C3B78_RS12155	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C3B78_RS12160	COG1414	Transcriptional regulator
C3B78_RS12195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3B78_RS12200	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3B78_RS12205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3B78_RS12210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C3B78_RS12215	COG0473	3-isopropylmalate dehydrogenase activity
C3B78_RS12235	COG1136	(ABC) transporter
C3B78_RS12235	COG0577	efflux transmembrane transporter activity
C3B78_RS12245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C3B78_RS12250	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C3B78_RS12255	COG0440	acetolactate synthase activity
C3B78_RS12265	COG0129	dihydroxy-acid dehydratase activity
C3B78_RS12300	COG0747	negative chemotaxis
C3B78_RS12305	COG0579	oxidoreductase
C3B78_RS12310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C3B78_RS12315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3B78_RS12325	COG1305	Transglutaminase-like
C3B78_RS12340	COG1104	cysteine desulfurase activity
C3B78_RS12350	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C3B78_RS12355	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C3B78_RS12365	COG1113	amino acid transport
C3B78_RS12395	COG0419	ATPase involved in DNA repair
C3B78_RS12400	COG0420	3'-5' exonuclease activity
C3B78_RS12405	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C3B78_RS12430	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C3B78_RS12435	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C3B78_RS12440	COG1234	tRNA 3'-trailer cleavage
C3B78_RS12445	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C3B78_RS12455	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C3B78_RS12465	COG1335	isochorismatase
C3B78_RS12480	COG0363	glucosamine-6-phosphate deaminase activity
C3B78_RS12495	COG1902	pentaerythritol trinitrate reductase activity
C3B78_RS12510	COG0628	permease
C3B78_RS12525	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C3B78_RS12535	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C3B78_RS12540	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C3B78_RS12550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C3B78_RS12555	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C3B78_RS12560	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C3B78_RS12565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C3B78_RS12570	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3B78_RS12575	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C3B78_RS12580	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3B78_RS12585	COG0356	it plays a direct role in the translocation of protons across the membrane
C3B78_RS12600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3B78_RS12605	COG1216	Glycosyl transferase, family 2
C3B78_RS12620	COG2890	protein-(glutamine-N5) methyltransferase activity
C3B78_RS12625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C3B78_RS12635	COG0083	homoserine kinase activity
C3B78_RS12640	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C3B78_RS12645	COG0460	homoserine dehydrogenase
C3B78_RS12650	COG0019	diaminopimelate decarboxylase activity
C3B78_RS12655	COG0018	arginyl-trna synthetase
C3B78_RS12670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C3B78_RS12670	COG1017	nitric oxide dioxygenase activity
C3B78_RS12695	COG1643	Atp-dependent helicase
C3B78_RS12700	COG0537	adenosine 5'-monophosphoramidase activity
C3B78_RS12705	COG1064	alcohol dehydrogenase
C3B78_RS12730	COG1121	(ABC) transporter
C3B78_RS12735	COG0803	Belongs to the bacterial solute-binding protein 9 family
C3B78_RS12745	COG1253	flavin adenine dinucleotide binding
C3B78_RS12750	COG0567	Dehydrogenase, E1 component
C3B78_RS12750	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3B78_RS12775	COG1595	DNA-templated transcription, initiation
C3B78_RS12785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C3B78_RS12795	COG0483	inositol monophosphate 1-phosphatase activity
C3B78_RS12800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C3B78_RS12815	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3B78_RS12820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3B78_RS12830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3B78_RS12840	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C3B78_RS12855	COG2884	Cell division ATP-binding protein ftsE
C3B78_RS12860	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C3B78_RS12930	COG1088	dTDP-glucose 4,6-dehydratase activity
C3B78_RS12940	COG1216	Glycosyl transferase, family 2
C3B78_RS12950	COG0463	Glycosyl transferase, family 2
C3B78_RS12950	COG1216	Glycosyl transferase, family 2
C3B78_RS12960	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C3B78_RS12980	COG1216	Glycosyl transferase, family 2
C3B78_RS13010	COG2902	Dehydrogenase
C3B78_RS13045	COG0653	protein targeting
C3B78_RS13050	COG3214	Protein conserved in bacteria
C3B78_RS13055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C3B78_RS13065	COG5401	PFAM Sporulation and spore germination
C3B78_RS13070	COG5002	protein histidine kinase activity
C3B78_RS13095	COG0714	Associated with various cellular activities
C3B78_RS13130	COG0601	transmembrane transport
C3B78_RS13140	COG0482	sulfurtransferase activity
C3B78_RS13160	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C3B78_RS13180	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C3B78_RS13185	COG2086	electron transfer activity
C3B78_RS13190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3B78_RS13200	COG1842	Phage shock protein A
C3B78_RS13205	COG0415	Belongs to the DNA photolyase family
C3B78_RS13220	COG1615	UPF0182 protein
C3B78_RS13225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C3B78_RS13245	COG2816	NAD+ diphosphatase activity
C3B78_RS13260	COG1074	ATP-dependent DNA helicase activity
C3B78_RS13275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3B78_RS13280	COG0765	amino acid transport
C3B78_RS13285	COG1126	abc transporter atp-binding protein
C3B78_RS13290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C3B78_RS13300	COG0113	porphobilinogen synthase activity
C3B78_RS13310	COG0181	hydroxymethylbilane synthase activity
C3B78_RS13315	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C3B78_RS13320	COG3253	May function as heme-dependent peroxidase
C3B78_RS13340	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C3B78_RS13345	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C3B78_RS13370	COG2154	pterin-4-alpha-carbinolamine dehydratase
C3B78_RS13375	COG2022	thiamine diphosphate biosynthetic process
C3B78_RS13385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3B78_RS13390	COG0352	thiamine-phosphate diphosphorylase activity
C3B78_RS13395	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C3B78_RS13400	COG0513	Belongs to the DEAD box helicase family
C3B78_RS13405	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C3B78_RS13410	COG0613	PHP domain protein
C3B78_RS13415	COG0006	proline dipeptidase activity
C3B78_RS13425	COG2239	Acts as a magnesium transporter
C3B78_RS13440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3B78_RS13450	COG1595	DNA-templated transcription, initiation
C3B78_RS13475	COG1611	Belongs to the LOG family
C3B78_RS13480	COG1126	abc transporter atp-binding protein
C3B78_RS13485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3B78_RS13490	COG0765	amino acid transport
C3B78_RS13495	COG0765	amino acid transport
C3B78_RS13500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3B78_RS13520	COG3226	Transcriptional regulator
C3B78_RS13525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C3B78_RS13550	COG1217	gtp-binding protein TYPA
C3B78_RS13565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3B78_RS13570	COG0601	transmembrane transport
C3B78_RS13585	COG0012	GTP binding
C3B78_RS13590	COG1322	Protein conserved in bacteria
C3B78_RS13595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C3B78_RS13605	COG1570	exodeoxyribonuclease VII activity
C3B78_RS13610	COG1722	exodeoxyribonuclease VII activity
C3B78_RS13615	COG2326	polyphosphate kinase activity
C3B78_RS13630	COG1174	glycine betaine transport
C3B78_RS13635	COG1174	glycine betaine transport
C3B78_RS13650	COG2971	BadF BadG BcrA BcrD
C3B78_RS13655	COG0583	DNA-binding transcription factor activity
C3B78_RS13660	COG2814	Major facilitator Superfamily
C3B78_RS13685	COG0598	Magnesium transport protein CorA
C3B78_RS13710	COG3655	Transcriptional regulator
C3B78_RS13735	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C3B78_RS13760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C3B78_RS13760	COG0519	Catalyzes the synthesis of GMP from XMP
C3B78_RS13780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C3B78_RS13785	COG0516	GMP reductase activity
C3B78_RS13790	COG1132	(ABC) transporter
C3B78_RS13800	COG2072	flavoprotein involved in K transport
C3B78_RS13810	COG2197	response regulator
C3B78_RS13815	COG1793	dna ligase
C3B78_RS13825	COG0459	protein refolding
C3B78_RS13830	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C3B78_RS13835	COG0697	spore germination
C3B78_RS13850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C3B78_RS13865	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C3B78_RS13870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C3B78_RS13875	COG0456	acetyltransferase
C3B78_RS13885	COG0802	atpase or kinase
C3B78_RS13890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C3B78_RS13900	COG1486	melibiose metabolic process
C3B78_RS13905	COG0438	transferase activity, transferring glycosyl groups
C3B78_RS13910	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C3B78_RS13925	COG0667	Aldo Keto reductase
C3B78_RS13950	COG0736	holo-[acyl-carrier-protein] synthase activity
C3B78_RS13955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C3B78_RS13960	COG1072	(Pantothenic acid kinase))
C3B78_RS13965	COG1876	peptidase activity
C3B78_RS13975	COG1970	mechanosensitive ion channel activity
C3B78_RS13980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3B78_RS13995	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C3B78_RS14000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C3B78_RS14005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C3B78_RS14035	COG0455	bacterial-type flagellum organization
C3B78_RS14075	COG2894	cell division
C3B78_RS14100	COG0745	RESPONSE REGULATOR receiver
C3B78_RS14105	COG2205	protein histidine kinase activity
C3B78_RS14105	COG2202	Pas domain
C3B78_RS14110	COG0101	tRNA pseudouridine synthase activity
C3B78_RS14115	COG0203	ribosomal protein L17
C3B78_RS14120	COG0202	RNA polymerase activity
C3B78_RS14125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C3B78_RS14130	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C3B78_RS14135	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C3B78_RS14140	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C3B78_RS14145	COG3191	aminopeptidase activity
C3B78_RS14155	COG0563	adenylate kinase activity
C3B78_RS14165	COG0200	Binds to the 23S rRNA
C3B78_RS14170	COG1841	ribosomal large subunit assembly
C3B78_RS14175	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C3B78_RS14185	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C3B78_RS14190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C3B78_RS14195	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C3B78_RS14200	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C3B78_RS14205	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C3B78_RS14210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C3B78_RS14215	COG0255	Belongs to the universal ribosomal protein uL29 family
C3B78_RS14220	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C3B78_RS14225	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C3B78_RS14230	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C3B78_RS14235	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C3B78_RS14240	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C3B78_RS14245	COG0089	rRNA binding
C3B78_RS14250	COG0088	Forms part of the polypeptide exit tunnel
C3B78_RS14255	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C3B78_RS14260	COG0051	transcription antitermination factor activity, RNA binding
C3B78_RS14270	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C3B78_RS14275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C3B78_RS14280	COG0049	tRNA binding
C3B78_RS14285	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C3B78_RS14290	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C3B78_RS14295	COG0085	RNA polymerase activity
C3B78_RS14300	COG0183	Belongs to the thiolase family
C3B78_RS14305	COG0442	prolyl-tRNA aminoacylation
C3B78_RS14310	COG0222	ribosome binding
C3B78_RS14315	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C3B78_RS14330	COG0081	regulation of translation
C3B78_RS14335	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C3B78_RS14345	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C3B78_RS14355	COG0436	Aminotransferase
C3B78_RS14360	COG2197	response regulator
C3B78_RS14405	COG3485	protocatechuate 3,4-dioxygenase
C3B78_RS14415	COG0745	RESPONSE REGULATOR receiver
C3B78_RS14420	COG0456	acetyltransferase
C3B78_RS14425	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C3B78_RS14435	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C3B78_RS14440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C3B78_RS14465	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C3B78_RS14475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C3B78_RS14485	COG2030	dehydratase
C3B78_RS14505	COG4989	oxidoreductase activity
C3B78_RS14510	COG0366	Alpha amylase catalytic
C3B78_RS14515	COG1940	carbohydrate kinase activity
C3B78_RS14545	COG2258	MOSC domain
C3B78_RS14555	COG0754	glutathionylspermidine amidase activity
C3B78_RS14565	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS14620	COG0318	PFAM AMP-dependent synthetase and ligase
C3B78_RS14630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3B78_RS14635	COG1131	(ABC) transporter
C3B78_RS14685	COG1666	GTP binding
C3B78_RS14690	COG0501	Belongs to the peptidase M48B family
C3B78_RS14720	COG0531	amino acid
C3B78_RS14760	COG3634	alkyl hydroperoxide reductase activity
C3B78_RS14770	COG1012	belongs to the aldehyde dehydrogenase family
C3B78_RS14775	COG3835	regulator
C3B78_RS14790	COG2186	Transcriptional regulator
C3B78_RS14825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C3B78_RS14825	COG1648	precorrin-2 dehydrogenase activity
C3B78_RS14835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3B78_RS14840	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C3B78_RS14850	COG1690	Belongs to the RtcB family
C3B78_RS14875	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3B78_RS14885	COG2860	membrane
C3B78_RS14900	COG0142	geranyltranstransferase activity
C3B78_RS14910	COG2226	methyltransferase
C3B78_RS14920	COG1169	isochorismate synthase
C3B78_RS14925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3B78_RS14930	COG0765	amino acid transport
C3B78_RS14945	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C3B78_RS14955	COG4948	Mandelate Racemase Muconate Lactonizing
C3B78_RS14960	COG0598	Magnesium transport protein CorA
C3B78_RS14965	COG3559	Exporter of polyketide antibiotics
C3B78_RS14970	COG1131	(ABC) transporter
C3B78_RS15005	COG2205	protein histidine kinase activity
C3B78_RS15055	COG0515	serine threonine protein kinase
C3B78_RS15075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C3B78_RS15080	COG0745	RESPONSE REGULATOR receiver
C3B78_RS15090	COG3300	MHYT domain
C3B78_RS15090	COG5001	Diguanylate cyclase
C3B78_RS15095	COG0596	Alpha beta hydrolase
C3B78_RS15100	COG3655	Transcriptional regulator
C3B78_RS15125	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C3B78_RS15125	COG2755	lipolytic protein G-D-S-L family
C3B78_RS15135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C3B78_RS15155	COG2203	Gaf domain
C3B78_RS15155	COG5001	Diguanylate cyclase
C3B78_RS15155	COG3706	GGDEF domain
C3B78_RS15155	COG4251	negative regulation of phosphorylation
C3B78_RS15175	COG1597	lipid kinase activity
C3B78_RS15195	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C3B78_RS15200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3B78_RS15205	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3B78_RS15210	COG1120	ATPase activity
C3B78_RS15220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3B78_RS15225	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3B78_RS15230	COG0022	dehydrogenase e1 component
C3B78_RS15255	COG2200	EAL domain
C3B78_RS15255	COG2199	diguanylate cyclase activity
C3B78_RS15270	COG5001	Diguanylate cyclase
C3B78_RS15275	COG0741	lytic transglycosylase activity
C3B78_RS15275	COG0739	heme binding
C3B78_RS15275	COG1196	nuclear chromosome segregation
C3B78_RS15280	COG4585	Histidine kinase
C3B78_RS15315	COG0745	RESPONSE REGULATOR receiver
C3B78_RS15370	COG5002	protein histidine kinase activity
C3B78_RS15390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C3B78_RS15400	COG0438	transferase activity, transferring glycosyl groups
C3B78_RS15420	COG1216	Glycosyl transferase, family 2
C3B78_RS15430	COG1132	(ABC) transporter
C3B78_RS15460	COG2089	acid synthase
C3B78_RS15465	COG1083	cytidylyl-transferase
C3B78_RS15495	COG0489	protein tyrosine kinase activity
C3B78_RS15545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3B78_RS15555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C3B78_RS15560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C3B78_RS15570	COG0489	protein tyrosine kinase activity
C3B78_RS15590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C3B78_RS15595	COG1024	Enoyl-CoA hydratase
C3B78_RS15600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C3B78_RS15605	COG2151	metal-sulfur cluster biosynthetic enzyme
C3B78_RS15610	COG3396	Phenylacetate-CoA oxygenase
C3B78_RS15615	COG3460	Phenylacetate-CoA oxygenase
C3B78_RS15620	COG3396	Phenylacetate-CoA oxygenase
C3B78_RS15675	COG3604	Transcriptional regulator
C3B78_RS15730	COG1620	l-lactate permease
C3B78_RS15740	COG2188	Transcriptional regulator
C3B78_RS15745	COG0277	FAD linked oxidase domain protein
C3B78_RS15750	COG1620	l-lactate permease
C3B78_RS15755	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C3B78_RS15760	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
C3B78_RS15780	COG0640	Transcriptional regulator
C3B78_RS15795	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C3B78_RS15820	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C3B78_RS15835	COG2217	Heavy metal translocating P-type atpase
C3B78_RS15850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C3B78_RS15855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C3B78_RS15860	COG1316	TRANSCRIPTIONal
C3B78_RS15875	COG0588	phosphoglycerate mutase activity
C3B78_RS15880	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C3B78_RS15930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C3B78_RS15940	COG0857	belongs to the CobB CobQ family
C3B78_RS15940	COG0280	phosphate acetyltransferase
C3B78_RS15945	COG2050	protein possibly involved in aromatic compounds catabolism
C3B78_RS15960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3B78_RS15975	COG2030	dehydratase
C3B78_RS15975	COG1012	belongs to the aldehyde dehydrogenase family
C3B78_RS15980	COG2050	protein possibly involved in aromatic compounds catabolism
C3B78_RS16000	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3B78_RS16005	COG1024	Enoyl-CoA hydratase
C3B78_RS16010	COG0183	Belongs to the thiolase family
C3B78_RS16035	COG2146	nitrite reductase [NAD(P)H] activity
C3B78_RS16040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3B78_RS16050	COG0488	(ABC) transporter
C3B78_RS16055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3B78_RS16060	COG1121	(ABC) transporter
C3B78_RS16070	COG1266	CAAX protease self-immunity
C3B78_RS16080	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C3B78_RS16135	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C3B78_RS16145	COG0785	Cytochrome C biogenesis protein
C3B78_RS16150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3B78_RS16155	COG0406	alpha-ribazole phosphatase activity
C3B78_RS16160	COG2353	YceI-like domain
C3B78_RS16175	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C3B78_RS16200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C3B78_RS16205	COG3458	cephalosporin-C deacetylase activity
C3B78_RS16210	COG1070	Carbohydrate kinase
C3B78_RS16215	COG3347	Dehydrogenase
C3B78_RS16215	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS16230	COG1609	Transcriptional regulator
C3B78_RS16250	COG2354	Protein conserved in bacteria
C3B78_RS16260	COG2755	lipolytic protein G-D-S-L family
C3B78_RS16265	COG0395	ABC-type sugar transport system, permease component
C3B78_RS16270	COG4209	transmembrane transport
C3B78_RS16275	COG1653	transport
C3B78_RS16280	COG5578	integral membrane protein
C3B78_RS16300	COG2814	Major facilitator Superfamily
C3B78_RS16310	COG0395	ABC-type sugar transport system, permease component
C3B78_RS16315	COG1175	transmembrane transport
C3B78_RS16340	COG0395	ABC-type sugar transport system, permease component
C3B78_RS16345	COG1175	transmembrane transport
C3B78_RS16355	COG0673	inositol 2-dehydrogenase activity
C3B78_RS16370	COG4948	Mandelate Racemase Muconate Lactonizing
C3B78_RS16375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3B78_RS16385	COG0673	inositol 2-dehydrogenase activity
C3B78_RS16390	COG1609	Transcriptional regulator
C3B78_RS16395	COG1802	Transcriptional regulator
C3B78_RS16405	COG0640	Transcriptional regulator
C3B78_RS16415	COG0123	including yeast histone deacetylase and acetoin utilization protein
C3B78_RS16420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C3B78_RS16425	COG0569	domain protein
C3B78_RS16430	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C3B78_RS16435	COG0248	Ppx GppA phosphatase
C3B78_RS16445	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C3B78_RS16445	COG1754	DNA topoisomerase type I activity
C3B78_RS16465	COG1054	Belongs to the UPF0176 family
C3B78_RS16475	COG1205	dead DEAH box helicase
C3B78_RS16475	COG1111	helicase
C3B78_RS16515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3B78_RS16515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3B78_RS16525	COG0494	nUDIX hydrolase
C3B78_RS16540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3B78_RS16545	COG1349	DNA-binding transcription factor activity
C3B78_RS16550	COG1609	Transcriptional regulator
C3B78_RS16565	COG0395	ABC-type sugar transport system, permease component
C3B78_RS16610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3B78_RS16615	COG1408	metallophosphoesterase
C3B78_RS16620	COG1132	(ABC) transporter
C3B78_RS16625	COG1132	(ABC) transporter
C3B78_RS16645	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C3B78_RS16650	COG0151	Belongs to the GarS family
C3B78_RS16685	COG0667	Aldo Keto reductase
C3B78_RS16690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3B78_RS16700	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C3B78_RS16700	COG3608	succinylglutamate desuccinylase aspartoacylase
C3B78_RS16705	COG2252	PERMEase
C3B78_RS16710	COG0590	tRNA wobble adenosine to inosine editing
C3B78_RS16725	COG2233	PERMEase
C3B78_RS16730	COG1414	Transcriptional regulator
C3B78_RS16740	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C3B78_RS16750	COG3257	ureidoglycine aminohydrolase activity
C3B78_RS16765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3B78_RS16775	COG3387	PFAM Glycoside hydrolase 15-related
C3B78_RS16800	COG0484	heat shock protein binding
C3B78_RS16810	COG0789	Transcriptional regulator
C3B78_RS16830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3B78_RS16835	COG0563	adenylate kinase activity
C3B78_RS16845	COG2267	carboxylic ester hydrolase activity
C3B78_RS16865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3B78_RS16900	COG1695	Transcriptional regulator
C3B78_RS16905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3B78_RS16905	COG4499	WXG100 protein secretion system (Wss), protein YukC
C3B78_RS16975	COG1064	alcohol dehydrogenase
C3B78_RS16980	COG2814	Major facilitator Superfamily
C3B78_RS16990	COG2133	pyrroloquinoline quinone binding
C3B78_RS17000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3B78_RS17010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3B78_RS17015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3B78_RS17065	COG1113	amino acid transport
C3B78_RS17075	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C3B78_RS17085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C3B78_RS17090	COG0509	glycine decarboxylation via glycine cleavage system
C3B78_RS17095	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C3B78_RS17100	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3B78_RS17100	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3B78_RS17110	COG0640	Transcriptional regulator
C3B78_RS17130	COG0402	S-adenosylhomocysteine deaminase activity
C3B78_RS17145	COG0402	S-adenosylhomocysteine deaminase activity
C3B78_RS17150	COG2271	Major facilitator Superfamily
C3B78_RS17160	COG4948	Mandelate Racemase Muconate Lactonizing
C3B78_RS17180	COG0395	ABC-type sugar transport system, permease component
C3B78_RS17185	COG1175	transmembrane transport
C3B78_RS17195	COG1609	Transcriptional regulator
C3B78_RS17200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3B78_RS17200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C3B78_RS17215	COG0363	glucosamine-6-phosphate deaminase activity
C3B78_RS17220	COG4821	SIS domain
C3B78_RS17225	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C3B78_RS17235	COG1609	Transcriptional regulator
C3B78_RS17285	COG3845	ABC transporter
C3B78_RS17290	COG2084	Dehydrogenase
C3B78_RS17295	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C3B78_RS17305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C3B78_RS17310	COG1609	Transcriptional regulator
C3B78_RS17315	COG0673	inositol 2-dehydrogenase activity
C3B78_RS17325	COG3265	gluconokinase activity
C3B78_RS17335	COG1063	alcohol dehydrogenase
C3B78_RS17340	COG1410	methionine synthase
C3B78_RS17340	COG0646	methionine synthase
C3B78_RS17350	COG0584	glycerophosphoryl diester phosphodiesterase
C3B78_RS17385	COG3848	Pyruvate phosphate dikinase
C3B78_RS17385	COG0574	Belongs to the PEP-utilizing enzyme family
C3B78_RS17400	COG3534	alpha-L-arabinofuranosidase
C3B78_RS17405	COG0395	ABC-type sugar transport system, permease component
C3B78_RS17410	COG1175	transmembrane transport
C3B78_RS17420	COG1609	Transcriptional regulator
C3B78_RS17445	COG1621	beta-fructofuranosidase activity
C3B78_RS17450	COG1609	Transcriptional regulator
C3B78_RS17455	COG0395	ABC-type sugar transport system, permease component
C3B78_RS17470	COG2329	Antibiotic biosynthesis monooxygenase
C3B78_RS17475	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C3B78_RS17480	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3B78_RS17485	COG1028	Short-chain dehydrogenase reductase Sdr
C3B78_RS17490	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C3B78_RS17495	COG0477	Major facilitator Superfamily
C3B78_RS17500	COG1609	Transcriptional regulator
C3B78_RS17550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C3B78_RS17555	COG0492	ferredoxin-NADP+ reductase activity
C3B78_RS17570	COG1914	H( )-stimulated, divalent metal cation uptake system
C3B78_RS17575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3B78_RS17640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3B78_RS17660	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C3B78_RS17680	COG1609	Transcriptional regulator
C3B78_RS17685	COG2190	(PTS) system
C3B78_RS17690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3B78_RS17695	COG1263	PTS System
C3B78_RS17700	COG0363	glucosamine-6-phosphate deaminase activity
C3B78_RS17705	COG3142	Participates in the control of copper homeostasis
C3B78_RS17710	COG0402	S-adenosylhomocysteine deaminase activity
C3B78_RS17740	COG0154	amidase activity
C3B78_RS17750	COG1473	amidohydrolase
C3B78_RS17755	COG0477	Major facilitator Superfamily
C3B78_RS17765	COG3622	Belongs to the hyi family
C3B78_RS17770	COG2084	Dehydrogenase
C3B78_RS17775	COG3960	tartronate-semialdehyde synthase activity
C3B78_RS17780	COG1929	Belongs to the glycerate kinase type-1 family
C3B78_RS17785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3B78_RS17825	COG2351	hydroxyisourate hydrolase activity
C3B78_RS17840	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C3B78_RS17855	COG1124	(ABC) transporter
C3B78_RS17860	COG2375	cellular response to nickel ion
C3B78_RS17860	COG1132	(ABC) transporter
C3B78_RS17900	COG3585	molybdate ion transport
C3B78_RS17920	COG0135	phosphoribosylanthranilate isomerase activity
C3B78_RS17930	COG0673	inositol 2-dehydrogenase activity
C3B78_RS17935	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C3B78_RS17950	COG1175	transmembrane transport
C3B78_RS17960	COG1940	carbohydrate kinase activity
C3B78_RS17965	COG1528	Iron-storage protein
C3B78_RS17975	COG2076	Multidrug Resistance protein
C3B78_RS17980	COG1072	(Pantothenic acid kinase))
C3B78_RS17985	COG0667	Aldo Keto reductase
C3B78_RS18010	COG2807	transmembrane transport
C3B78_RS18020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C3B78_RS18035	COG1595	DNA-templated transcription, initiation
C3B78_RS18070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C3B78_RS18090	COG0673	inositol 2-dehydrogenase activity
C3B78_RS18115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C3B78_RS18135	COG3971	2-oxopent-4-enoate hydratase activity
C3B78_RS18145	COG1937	Protein conserved in bacteria
C3B78_RS18150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C3B78_RS18160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C3B78_RS18170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3B78_RS18175	COG2814	Major facilitator Superfamily
C3B78_RS18185	COG0789	Transcriptional regulator
C3B78_RS18190	COG0484	heat shock protein binding
C3B78_RS18195	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C3B78_RS18200	COG0443	Heat shock 70 kDa protein
C3B78_RS18210	COG2409	Drug exporters of the RND superfamily
C3B78_RS18225	COG1280	lysine exporter protein (LysE YggA)
C3B78_RS18230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C3B78_RS18240	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C3B78_RS18250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C3B78_RS18300	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C3B78_RS18305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C3B78_RS18320	COG1122	ATPase activity
C3B78_RS18325	COG4721	ABC-type cobalt transport system, permease component
C3B78_RS18330	COG4702	Belongs to the UPF0303 family
C3B78_RS18355	COG1320	monovalent cation:proton antiporter activity
C3B78_RS18360	COG2212	antiporter activity
C3B78_RS18370	COG0651	ATP synthesis coupled electron transport
C3B78_RS18375	COG1006	Multisubunit Na H antiporter MnhC subunit
C3B78_RS18380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C3B78_RS18380	COG2111	Na H antiporter
C3B78_RS18390	COG2985	domain, Protein
C3B78_RS18390	COG0569	domain protein
C3B78_RS18395	COG0475	glutathione-regulated potassium exporter activity
C3B78_RS18400	COG0717	Belongs to the dCTP deaminase family
C3B78_RS18430	COG0583	DNA-binding transcription factor activity
C3B78_RS18440	COG1012	belongs to the aldehyde dehydrogenase family
C3B78_RS18445	COG0531	amino acid
C3B78_RS18450	COG0583	DNA-binding transcription factor activity
C3B78_RS18455	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C3B78_RS18470	COG2814	Major facilitator Superfamily
C3B78_RS18475	COG3387	PFAM Glycoside hydrolase 15-related
C3B78_RS18480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3B78_RS18485	COG0667	Aldo Keto reductase
C3B78_RS18500	COG1012	belongs to the aldehyde dehydrogenase family
C3B78_RS18515	COG1846	Transcriptional regulator
C3B78_RS18515	COG1940	carbohydrate kinase activity
C3B78_RS18525	COG1175	transmembrane transport
C3B78_RS18530	COG0395	ABC-type sugar transport system, permease component
C3B78_RS18535	COG0366	Alpha amylase catalytic
C3B78_RS18545	COG0433	COG0433 Predicted ATPase
C3B78_RS18565	COG3336	cytochrome c oxidase
C3B78_RS18570	COG0776	regulation of translation
C3B78_RS18595	COG1609	Transcriptional regulator
C3B78_RS18615	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C3B78_RS18620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C3B78_RS18625	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C3B78_RS18655	COG2375	cellular response to nickel ion
C3B78_RS18660	COG1120	ATPase activity
C3B78_RS18665	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3B78_RS18670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3B78_RS18710	COG3012	SEC-C Motif Domain Protein
C3B78_RS18720	COG0667	Aldo Keto reductase
C3B78_RS18735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3B78_RS18780	COG2186	Transcriptional regulator
C3B78_RS18790	COG1027	Aspartate ammonia-lyase
C3B78_RS18800	COG0405	Gamma-glutamyltransferase
C3B78_RS18805	COG0039	L-malate dehydrogenase activity
C3B78_RS18815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3B78_RS18830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3B78_RS18845	COG1280	lysine exporter protein (LysE YggA)
C3B78_RS18865	COG0281	malic enzyme
C3B78_RS18870	COG1309	transcriptional regulator
C3B78_RS18885	COG0477	Major facilitator Superfamily
C3B78_RS18895	COG0246	Mannitol dehydrogenase
C3B78_RS18900	COG2213	PTS system mannitol-specific
C3B78_RS18900	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3B78_RS18910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C3B78_RS18915	COG0596	Alpha beta hydrolase
C3B78_RS18930	COG0686	Belongs to the AlaDH PNT family
C3B78_RS18935	COG0673	inositol 2-dehydrogenase activity
C3B78_RS18970	COG1793	dna ligase
C3B78_RS18970	COG3285	dna ligase
C3B78_RS18980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3B78_RS19000	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3B78_RS19005	COG0022	dehydrogenase e1 component
C3B78_RS19015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3B78_RS19025	COG1950	PFAM Membrane protein of
C3B78_RS19040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C3B78_RS19045	COG0406	alpha-ribazole phosphatase activity
C3B78_RS19050	COG2815	serine threonine protein kinase
C3B78_RS19050	COG0515	serine threonine protein kinase
C3B78_RS19070	COG1607	acyl-coa hydrolase
C3B78_RS19075	COG1840	ABC-type Fe3 transport system, periplasmic component
C3B78_RS19080	COG3842	ATPase activity
C3B78_RS19085	COG1178	ABC-type Fe3 transport system permease component
C3B78_RS19100	COG1597	lipid kinase activity
C3B78_RS19120	COG1414	Transcriptional regulator
C3B78_RS19125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C3B78_RS19130	COG0477	Major facilitator Superfamily
C3B78_RS19135	COG1414	Transcriptional regulator
C3B78_RS19140	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C3B78_RS19150	COG0183	Belongs to the thiolase family
C3B78_RS19155	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C3B78_RS19160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C3B78_RS19170	COG3485	protocatechuate 3,4-dioxygenase
C3B78_RS19175	COG3485	protocatechuate 3,4-dioxygenase
C3B78_RS19180	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C3B78_RS19180	COG1082	Xylose isomerase domain protein TIM barrel
C3B78_RS19185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C3B78_RS19190	COG1414	Transcriptional regulator
C3B78_RS19200	COG1793	dna ligase
C3B78_RS19260	COG1937	Protein conserved in bacteria
C3B78_RS19285	COG0697	spore germination
C3B78_RS19310	COG2259	Doxx family
C3B78_RS19320	COG0305	Participates in initiation and elongation during chromosome replication
C3B78_RS19345	COG0359	binds to the 23S rRNA
C3B78_RS19350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C3B78_RS19360	COG0360	Binds together with S18 to 16S ribosomal RNA
C3B78_RS19420	COG1216	Glycosyl transferase, family 2
C3B78_RS19420	COG0438	transferase activity, transferring glycosyl groups
C3B78_RS19425	COG0463	Glycosyl transferase, family 2
C3B78_RS19430	COG1362	aminopeptidase activity
C3B78_RS19440	COG1131	(ABC) transporter
C3B78_RS19450	COG0738	Major facilitator superfamily
C3B78_RS19460	COG0488	(ABC) transporter
C3B78_RS19465	COG0154	amidase activity
C3B78_RS19470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3B78_RS19475	COG0477	Major facilitator Superfamily
C3B78_RS19495	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C3B78_RS19515	COG0406	alpha-ribazole phosphatase activity
C3B78_RS19520	COG0617	tRNA 3'-terminal CCA addition
C3B78_RS19540	COG0492	ferredoxin-NADP+ reductase activity
C3B78_RS19545	COG3118	belongs to the thioredoxin family
C3B78_RS19555	COG1192	Involved in chromosome partitioning
C3B78_RS19560	COG0357	Ribosomal RNA small subunit methyltransferase G
C3B78_RS19570	COG0706	membrane insertase activity
C3B78_RS19575	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C3B78_RS19580	COG0594	ribonuclease P activity
C3B78_RS19585	COG0230	Belongs to the bacterial ribosomal protein bL34 family