locus-tag	class	description
LDN75_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LDN75_RS00010	COG0592	DNA-directed DNA polymerase activity
LDN75_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LDN75_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LDN75_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
LDN75_RS00030	COG0187	DNA topoisomerase II activity
LDN75_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LDN75_RS00040	COG3266	domain, Protein
LDN75_RS00060	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LDN75_RS00060	COG3291	Pkd domain containing protein
LDN75_RS00070	COG1215	transferase activity, transferring glycosyl groups
LDN75_RS00085	COG0457	Tetratricopeptide repeat
LDN75_RS00085	COG0705	Rhomboid family
LDN75_RS00095	COG2818	Glycosylase
LDN75_RS00105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LDN75_RS00110	COG1595	DNA-templated transcription, initiation
LDN75_RS00125	COG3764	Sortase (surface protein transpeptidase)
LDN75_RS00140	COG0515	serine threonine protein kinase
LDN75_RS00145	COG0515	serine threonine protein kinase
LDN75_RS00150	COG0768	penicillin binding
LDN75_RS00165	COG1716	ATPase activity
LDN75_RS00170	COG1716	ATPase activity
LDN75_RS00180	COG1609	Transcriptional regulator
LDN75_RS00210	COG0346	lactoylglutathione lyase activity
LDN75_RS00225	COG2186	Transcriptional regulator
LDN75_RS00230	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LDN75_RS00235	COG0477	Major facilitator Superfamily
LDN75_RS00240	COG1984	allophanate hydrolase subunit 2
LDN75_RS00245	COG4770	biotin carboxylase activity
LDN75_RS00250	COG0277	FAD linked oxidase domain protein
LDN75_RS00260	COG0385	Bile acid
LDN75_RS00265	COG0659	secondary active sulfate transmembrane transporter activity
LDN75_RS00290	COG0561	phosphatase activity
LDN75_RS00310	COG3250	beta-galactosidase activity
LDN75_RS00315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDN75_RS00320	COG1929	Belongs to the glycerate kinase type-1 family
LDN75_RS00340	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LDN75_RS00355	COG2192	nodulation
LDN75_RS00370	COG0494	nUDIX hydrolase
LDN75_RS00380	COG1216	Glycosyl transferase, family 2
LDN75_RS00390	COG3415	Transposase
LDN75_RS00390	COG2801	Transposase and inactivated derivatives
LDN75_RS00395	COG0693	protein deglycase activity
LDN75_RS00400	COG2233	PERMEase
LDN75_RS00405	COG0778	Nitroreductase
LDN75_RS00425	COG3104	oligopeptide transport
LDN75_RS00435	COG3340	Belongs to the peptidase S51 family
LDN75_RS00440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LDN75_RS00440	COG0425	Belongs to the sulfur carrier protein TusA family
LDN75_RS00455	COG1597	lipid kinase activity
LDN75_RS00460	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LDN75_RS00470	COG0561	phosphatase activity
LDN75_RS00485	COG1191	sigma factor activity
LDN75_RS00500	COG0859	PFAM glycosyl transferase family 9
LDN75_RS00510	COG0438	transferase activity, transferring glycosyl groups
LDN75_RS00515	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LDN75_RS00520	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LDN75_RS00520	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LDN75_RS00535	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LDN75_RS00535	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LDN75_RS00605	COG0037	tRNA processing
LDN75_RS00615	COG1609	Transcriptional regulator
LDN75_RS00620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDN75_RS00625	COG0302	gtp cyclohydrolase
LDN75_RS00635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LDN75_RS00665	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LDN75_RS00670	COG2814	Major facilitator Superfamily
LDN75_RS00755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LDN75_RS00775	COG1506	peptidase
LDN75_RS00775	COG0823	Involved in the tonB-independent uptake of proteins
LDN75_RS00780	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LDN75_RS00790	COG2376	Dihydroxyacetone kinase
LDN75_RS00795	COG1461	Dihydroxyacetone kinase
LDN75_RS00800	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LDN75_RS00805	COG3237	CsbD-like
LDN75_RS00825	COG2207	Transcriptional regulator
LDN75_RS00830	COG1301	dicarboxylic acid transport
LDN75_RS00845	COG1194	a g-specific adenine glycosylase
LDN75_RS00855	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LDN75_RS00875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LDN75_RS00885	COG0581	inorganic phosphate transmembrane transporter activity
LDN75_RS00890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LDN75_RS00895	COG0306	phosphate transporter
LDN75_RS00955	COG0436	Aminotransferase
LDN75_RS00960	COG0586	Pfam SNARE associated Golgi protein
LDN75_RS00965	COG0831	urea catabolic process
LDN75_RS00970	COG0832	Belongs to the urease beta subunit family
LDN75_RS00975	COG0804	urea catabolic process
LDN75_RS00980	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LDN75_RS00990	COG0830	nickel cation binding
LDN75_RS00995	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LDN75_RS01000	COG0829	nickel cation binding
LDN75_RS01005	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LDN75_RS01040	COG2706	6-phosphogluconolactonase activity
LDN75_RS01045	COG0656	L-ascorbic acid biosynthetic process
LDN75_RS01055	COG0667	Aldo Keto reductase
LDN75_RS01060	COG0656	L-ascorbic acid biosynthetic process
LDN75_RS01070	COG3360	Dodecin
LDN75_RS01085	COG2186	Transcriptional regulator
LDN75_RS01090	COG2267	carboxylic ester hydrolase activity
LDN75_RS01100	COG2084	Dehydrogenase
LDN75_RS01105	COG2610	gluconate transmembrane transporter activity
LDN75_RS01125	COG0477	Major facilitator Superfamily
LDN75_RS01130	COG2175	clavaminate synthase activity
LDN75_RS01140	COG2080	2 iron, 2 sulfur cluster binding
LDN75_RS01145	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LDN75_RS01155	COG1012	belongs to the aldehyde dehydrogenase family
LDN75_RS01180	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS01185	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS01190	COG0028	Belongs to the TPP enzyme family
LDN75_RS01215	COG1846	Transcriptional regulator
LDN75_RS01260	COG3486	L-lysine 6-monooxygenase (NADPH) activity
LDN75_RS01295	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS01305	COG0667	Aldo Keto reductase
LDN75_RS01320	COG0346	lactoylglutathione lyase activity
LDN75_RS01325	COG0697	spore germination
LDN75_RS01330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDN75_RS01335	COG0477	Major facilitator Superfamily
LDN75_RS01340	COG2890	protein-(glutamine-N5) methyltransferase activity
LDN75_RS01360	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LDN75_RS01365	COG0395	ABC-type sugar transport system, permease component
LDN75_RS01370	COG1175	transmembrane transport
LDN75_RS01385	COG2186	Transcriptional regulator
LDN75_RS01430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LDN75_RS01435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LDN75_RS01435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LDN75_RS01435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDN75_RS01440	COG1105	Belongs to the carbohydrate kinase PfkB family
LDN75_RS01445	COG1349	DNA-binding transcription factor activity
LDN75_RS01465	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LDN75_RS01490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDN75_RS01520	COG1846	Transcriptional regulator
LDN75_RS01545	COG0142	geranyltranstransferase activity
LDN75_RS01550	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LDN75_RS01570	COG2755	lipolytic protein G-D-S-L family
LDN75_RS01580	COG2186	Transcriptional regulator
LDN75_RS01595	COG0129	dihydroxy-acid dehydratase activity
LDN75_RS01625	COG1802	Transcriptional regulator
LDN75_RS01635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LDN75_RS01645	COG1126	abc transporter atp-binding protein
LDN75_RS01650	COG0765	amino acid transport
LDN75_RS01655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDN75_RS01665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDN75_RS01670	COG1012	belongs to the aldehyde dehydrogenase family
LDN75_RS01675	COG0473	3-isopropylmalate dehydrogenase activity
LDN75_RS01695	COG5006	permease, DMT superfamily
LDN75_RS01700	COG1609	Transcriptional regulator
LDN75_RS01705	COG0673	inositol 2-dehydrogenase activity
LDN75_RS01710	COG0673	inositol 2-dehydrogenase activity
LDN75_RS01745	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LDN75_RS01750	COG1984	allophanate hydrolase subunit 2
LDN75_RS01760	COG2733	membrane
LDN75_RS01805	COG4122	O-methyltransferase activity
LDN75_RS01830	COG0583	DNA-binding transcription factor activity
LDN75_RS01840	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS01850	COG1131	(ABC) transporter
LDN75_RS01855	COG3559	Exporter of polyketide antibiotics
LDN75_RS01870	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LDN75_RS01890	COG2902	Dehydrogenase
LDN75_RS01895	COG2801	Transposase and inactivated derivatives
LDN75_RS01895	COG3415	Transposase
LDN75_RS01910	COG0010	Belongs to the arginase family
LDN75_RS01915	COG2252	PERMEase
LDN75_RS01940	COG0574	Belongs to the PEP-utilizing enzyme family
LDN75_RS01940	COG3848	Pyruvate phosphate dikinase
LDN75_RS01970	COG3655	Transcriptional regulator
LDN75_RS02025	COG2365	Tyrosine phosphatase family
LDN75_RS02030	COG1309	transcriptional regulator
LDN75_RS02050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LDN75_RS02065	COG1309	transcriptional regulator
LDN75_RS02085	COG1653	transport
LDN75_RS02090	COG0395	ABC-type sugar transport system, permease component
LDN75_RS02095	COG1175	transmembrane transport
LDN75_RS02100	COG1285	pathogenesis
LDN75_RS02125	COG1302	Protein conserved in bacteria
LDN75_RS02170	COG1653	transport
LDN75_RS02175	COG1175	transmembrane transport
LDN75_RS02180	COG0395	ABC-type sugar transport system, permease component
LDN75_RS02185	COG1609	Transcriptional regulator
LDN75_RS02205	COG2197	response regulator
LDN75_RS02210	COG4585	Histidine kinase
LDN75_RS02225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LDN75_RS02230	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LDN75_RS02235	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LDN75_RS02260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LDN75_RS02265	COG1414	Transcriptional regulator
LDN75_RS02270	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LDN75_RS02275	COG0303	'Molybdopterin
LDN75_RS02280	COG1063	alcohol dehydrogenase
LDN75_RS02300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LDN75_RS02305	COG3404	Formiminotransferase-cyclodeaminase
LDN75_RS02320	COG1802	Transcriptional regulator
LDN75_RS02325	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LDN75_RS02330	COG0583	DNA-binding transcription factor activity
LDN75_RS02345	COG2197	response regulator
LDN75_RS02370	COG0415	Belongs to the DNA photolyase family
LDN75_RS02380	COG1024	Enoyl-CoA hydratase
LDN75_RS02420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDN75_RS02425	COG1960	acyl-CoA dehydrogenase activity
LDN75_RS02440	COG1012	belongs to the aldehyde dehydrogenase family
LDN75_RS02460	COG0789	Transcriptional regulator
LDN75_RS02465	COG1695	Transcriptional regulator
LDN75_RS02475	COG1012	belongs to the aldehyde dehydrogenase family
LDN75_RS02480	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LDN75_RS02490	COG0531	amino acid
LDN75_RS02495	COG2186	Transcriptional regulator
LDN75_RS02505	COG1609	Transcriptional regulator
LDN75_RS02515	COG1175	transmembrane transport
LDN75_RS02520	COG0395	ABC-type sugar transport system, permease component
LDN75_RS02530	COG0673	inositol 2-dehydrogenase activity
LDN75_RS02540	COG1904	glucuronate isomerase
LDN75_RS02545	COG0246	Mannitol dehydrogenase
LDN75_RS02550	COG4948	Mandelate Racemase Muconate Lactonizing
LDN75_RS02555	COG3265	gluconokinase activity
LDN75_RS02575	COG4213	ABC transporter substrate-binding protein
LDN75_RS02580	COG1129	ABC transporter
LDN75_RS02585	COG4214	carbohydrate transport
LDN75_RS02590	COG1609	Transcriptional regulator
LDN75_RS02600	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDN75_RS02615	COG2814	Major facilitator Superfamily
LDN75_RS02620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDN75_RS02625	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LDN75_RS02655	COG2801	Transposase and inactivated derivatives
LDN75_RS02655	COG3415	Transposase
LDN75_RS02665	COG2801	Transposase and inactivated derivatives
LDN75_RS02665	COG3415	Transposase
LDN75_RS02685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LDN75_RS02690	COG2814	Major facilitator Superfamily
LDN75_RS02700	COG2814	Major facilitator Superfamily
LDN75_RS02705	COG2072	flavoprotein involved in K transport
LDN75_RS02730	COG0583	DNA-binding transcription factor activity
LDN75_RS02750	COG1012	belongs to the aldehyde dehydrogenase family
LDN75_RS02755	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LDN75_RS02760	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LDN75_RS02770	COG0477	Major facilitator Superfamily
LDN75_RS02815	COG1609	Transcriptional regulator
LDN75_RS02825	COG0765	amino acid transport
LDN75_RS02830	COG1126	abc transporter atp-binding protein
LDN75_RS02835	COG0673	inositol 2-dehydrogenase activity
LDN75_RS02860	COG1832	CoA-binding protein
LDN75_RS02870	COG2315	Protein conserved in bacteria
LDN75_RS02880	COG1653	transport
LDN75_RS02885	COG1175	transmembrane transport
LDN75_RS02890	COG0395	ABC-type sugar transport system, permease component
LDN75_RS02905	COG2368	4-hydroxyphenylacetate
LDN75_RS02940	COG3706	GGDEF domain
LDN75_RS02955	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LDN75_RS02960	COG0047	phosphoribosylformylglycinamidine synthase activity
LDN75_RS02980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDN75_RS03015	COG1846	Transcriptional regulator
LDN75_RS03025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LDN75_RS03035	COG5416	Lipopolysaccharide assembly protein A domain
LDN75_RS03070	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LDN75_RS03095	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LDN75_RS03105	COG3415	Transposase
LDN75_RS03105	COG2801	Transposase and inactivated derivatives
LDN75_RS03115	COG1012	belongs to the aldehyde dehydrogenase family
LDN75_RS03120	COG3842	ATPase activity
LDN75_RS03155	COG0739	heme binding
LDN75_RS03155	COG0741	lytic transglycosylase activity
LDN75_RS03155	COG1196	nuclear chromosome segregation
LDN75_RS03160	COG0386	Belongs to the glutathione peroxidase family
LDN75_RS03165	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LDN75_RS03190	COG1309	transcriptional regulator
LDN75_RS03195	COG1609	Transcriptional regulator
LDN75_RS03205	COG1175	transmembrane transport
LDN75_RS03210	COG0395	ABC-type sugar transport system, permease component
LDN75_RS03225	COG0438	transferase activity, transferring glycosyl groups
LDN75_RS03240	COG0589	response to stress
LDN75_RS03260	COG3290	protein histidine kinase activity
LDN75_RS03265	COG4565	transcriptional regulatory protein
LDN75_RS03290	COG1940	carbohydrate kinase activity
LDN75_RS03325	COG0823	Involved in the tonB-independent uptake of proteins
LDN75_RS03335	COG0673	inositol 2-dehydrogenase activity
LDN75_RS03340	COG0673	inositol 2-dehydrogenase activity
LDN75_RS03350	COG0395	ABC-type sugar transport system, permease component
LDN75_RS03360	COG2182	Extracellular solute-binding protein
LDN75_RS03365	COG0673	inositol 2-dehydrogenase activity
LDN75_RS03375	COG1846	Transcriptional regulator
LDN75_RS03375	COG1940	carbohydrate kinase activity
LDN75_RS03385	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LDN75_RS03395	COG1476	TRANSCRIPTIONal
LDN75_RS03405	COG1309	transcriptional regulator
LDN75_RS03415	COG0351	phosphomethylpyrimidine kinase
LDN75_RS03425	COG2205	protein histidine kinase activity
LDN75_RS03430	COG0745	RESPONSE REGULATOR receiver
LDN75_RS03435	COG0477	Major facilitator Superfamily
LDN75_RS03450	COG0343	queuine tRNA-ribosyltransferase activity
LDN75_RS03485	COG3842	ATPase activity
LDN75_RS03535	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LDN75_RS03560	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LDN75_RS03570	COG0586	Pfam SNARE associated Golgi protein
LDN75_RS03595	COG0564	pseudouridine synthase activity
LDN75_RS03620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDN75_RS03625	COG2364	Membrane
LDN75_RS03630	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LDN75_RS03635	COG1201	RNA secondary structure unwinding
LDN75_RS03660	COG2271	Major facilitator Superfamily
LDN75_RS03705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LDN75_RS03730	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
LDN75_RS03740	COG1175	transmembrane transport
LDN75_RS03750	COG1609	Transcriptional regulator
LDN75_RS03765	COG2205	protein histidine kinase activity
LDN75_RS03770	COG0745	RESPONSE REGULATOR receiver
LDN75_RS03780	COG2062	phosphohistidine phosphatase, SixA
LDN75_RS03785	COG0583	DNA-binding transcription factor activity
LDN75_RS03790	COG0697	spore germination
LDN75_RS03800	COG1309	transcriptional regulator
LDN75_RS03805	COG1511	domain protein
LDN75_RS03825	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
LDN75_RS03830	COG1940	carbohydrate kinase activity
LDN75_RS03835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDN75_RS03840	COG4608	Belongs to the ABC transporter superfamily
LDN75_RS03845	COG0444	Belongs to the ABC transporter superfamily
LDN75_RS03850	COG0601	transmembrane transport
LDN75_RS03855	COG0747	negative chemotaxis
LDN75_RS03870	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LDN75_RS03890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LDN75_RS03895	COG0514	ATP-dependent DNA helicase (RecQ)
LDN75_RS03900	COG2814	Major facilitator Superfamily
LDN75_RS03910	COG1505	serine-type exopeptidase activity
LDN75_RS03920	COG1113	amino acid transport
LDN75_RS03940	COG0604	alcohol dehydrogenase
LDN75_RS03940	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS03940	COG3321	synthase
LDN75_RS03950	COG1966	Carbon starvation protein
LDN75_RS03970	COG0656	L-ascorbic acid biosynthetic process
LDN75_RS03980	COG0154	amidase activity
LDN75_RS04000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDN75_RS04020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LDN75_RS04030	COG0444	Belongs to the ABC transporter superfamily
LDN75_RS04035	COG4608	Belongs to the ABC transporter superfamily
LDN75_RS04060	COG1335	isochorismatase
LDN75_RS04105	COG0402	S-adenosylhomocysteine deaminase activity
LDN75_RS04115	COG0154	amidase activity
LDN75_RS04135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LDN75_RS04140	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LDN75_RS04160	COG0588	phosphoglycerate mutase activity
LDN75_RS04190	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LDN75_RS04195	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LDN75_RS04205	COG0215	cysteine-tRNA ligase activity
LDN75_RS04240	COG0366	Alpha amylase catalytic
LDN75_RS04250	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LDN75_RS04285	COG1609	Transcriptional regulator
LDN75_RS04290	COG0366	Alpha amylase catalytic
LDN75_RS04305	COG3833	ABC-type maltose transport systems, permease component
LDN75_RS04310	COG0366	Alpha amylase catalytic
LDN75_RS04315	COG0277	FAD linked oxidase domain protein
LDN75_RS04330	COG0402	S-adenosylhomocysteine deaminase activity
LDN75_RS04335	COG4608	Belongs to the ABC transporter superfamily
LDN75_RS04340	COG0444	Belongs to the ABC transporter superfamily
LDN75_RS04345	COG0601	transmembrane transport
LDN75_RS04350	COG0747	negative chemotaxis
LDN75_RS04355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDN75_RS04360	COG0402	S-adenosylhomocysteine deaminase activity
LDN75_RS04380	COG3842	ATPase activity
LDN75_RS04415	COG0475	glutathione-regulated potassium exporter activity
LDN75_RS04430	COG3634	alkyl hydroperoxide reductase activity
LDN75_RS04455	COG1653	transport
LDN75_RS04460	COG1175	transmembrane transport
LDN75_RS04465	COG0395	ABC-type sugar transport system, permease component
LDN75_RS04470	COG3250	beta-galactosidase activity
LDN75_RS04480	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS04490	COG1960	acyl-CoA dehydrogenase activity
LDN75_RS04500	COG0477	Major facilitator Superfamily
LDN75_RS04530	COG0579	oxidoreductase
LDN75_RS04550	COG2957	Belongs to the agmatine deiminase family
LDN75_RS04575	COG0477	Major facilitator Superfamily
LDN75_RS04585	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LDN75_RS04585	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LDN75_RS04590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LDN75_RS04595	COG0509	glycine decarboxylation via glycine cleavage system
LDN75_RS04600	COG1760	l-serine dehydratase
LDN75_RS04605	COG1864	DNA RNA non-specific endonuclease
LDN75_RS04605	COG3591	Belongs to the peptidase S1B family
LDN75_RS04625	COG0577	efflux transmembrane transporter activity
LDN75_RS04625	COG1136	(ABC) transporter
LDN75_RS04650	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LDN75_RS04670	COG0459	protein refolding
LDN75_RS04675	COG0328	RNA-DNA hybrid ribonuclease activity
LDN75_RS04685	COG2205	protein histidine kinase activity
LDN75_RS04690	COG0745	RESPONSE REGULATOR receiver
LDN75_RS04700	COG0583	DNA-binding transcription factor activity
LDN75_RS04710	COG2132	Multicopper oxidase
LDN75_RS04735	COG1278	Cold shock
LDN75_RS04755	COG0739	heme binding
LDN75_RS04760	COG0791	NLP P60 protein
LDN75_RS04760	COG1388	LysM domain
LDN75_RS04760	COG3103	Sh3 type 3 domain protein
LDN75_RS04775	COG0746	molybdenum cofactor guanylyltransferase activity
LDN75_RS04790	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LDN75_RS04800	COG1126	abc transporter atp-binding protein
LDN75_RS04805	COG0765	amino acid transport
LDN75_RS04810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDN75_RS04825	COG0488	(ABC) transporter
LDN75_RS04830	COG1132	(ABC) transporter
LDN75_RS04835	COG0494	nUDIX hydrolase
LDN75_RS04865	COG0483	inositol monophosphate 1-phosphatase activity
LDN75_RS04880	COG0045	succinate-CoA ligase (ADP-forming) activity
LDN75_RS04895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDN75_RS04905	COG3962	Belongs to the TPP enzyme family
LDN75_RS04920	COG0673	inositol 2-dehydrogenase activity
LDN75_RS04925	COG1082	Xylose isomerase domain protein TIM barrel
LDN75_RS04930	COG3718	enzyme involved in inositol metabolism
LDN75_RS04935	COG2188	Transcriptional regulator
LDN75_RS04945	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDN75_RS04955	COG1609	Transcriptional regulator
LDN75_RS04970	COG0673	inositol 2-dehydrogenase activity
LDN75_RS04980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LDN75_RS04980	COG0519	Catalyzes the synthesis of GMP from XMP
LDN75_RS05025	COG1396	sequence-specific DNA binding
LDN75_RS05040	COG0028	Belongs to the TPP enzyme family
LDN75_RS05045	COG0477	Major facilitator Superfamily
LDN75_RS05055	COG0583	DNA-binding transcription factor activity
LDN75_RS05085	COG3142	Participates in the control of copper homeostasis
LDN75_RS05090	COG1621	beta-fructofuranosidase activity
LDN75_RS05105	COG1653	transport
LDN75_RS05115	COG0395	ABC-type sugar transport system, permease component
LDN75_RS05125	COG1609	Transcriptional regulator
LDN75_RS05130	COG1621	beta-fructofuranosidase activity
LDN75_RS05145	COG0739	heme binding
LDN75_RS05145	COG0741	lytic transglycosylase activity
LDN75_RS05145	COG1196	nuclear chromosome segregation
LDN75_RS05150	COG1401	restriction endodeoxyribonuclease activity
LDN75_RS05165	COG5002	protein histidine kinase activity
LDN75_RS05170	COG0745	RESPONSE REGULATOR receiver
LDN75_RS05175	COG2267	carboxylic ester hydrolase activity
LDN75_RS05190	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LDN75_RS05200	COG0183	Belongs to the thiolase family
LDN75_RS05205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LDN75_RS05215	COG1024	Enoyl-CoA hydratase
LDN75_RS05245	COG1012	belongs to the aldehyde dehydrogenase family
LDN75_RS05250	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS05260	COG1024	Enoyl-CoA hydratase
LDN75_RS05265	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDN75_RS05275	COG0477	Major facilitator Superfamily
LDN75_RS05280	COG1396	sequence-specific DNA binding
LDN75_RS05300	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LDN75_RS05305	COG0156	8-amino-7-oxononanoate synthase activity
LDN75_RS05310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LDN75_RS05315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LDN75_RS05325	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS05345	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LDN75_RS05350	COG1902	pentaerythritol trinitrate reductase activity
LDN75_RS05365	COG2376	Dihydroxyacetone kinase
LDN75_RS05370	COG0698	ribose 5-phosphate isomerase
LDN75_RS05375	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDN75_RS05380	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS05385	COG2271	Major facilitator Superfamily
LDN75_RS05390	COG0149	triose-phosphate isomerase activity
LDN75_RS05435	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LDN75_RS05445	COG1254	Belongs to the acylphosphatase family
LDN75_RS05450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDN75_RS05455	COG2186	Transcriptional regulator
LDN75_RS05460	COG0477	Major facilitator Superfamily
LDN75_RS05470	COG0640	Transcriptional regulator
LDN75_RS05480	COG4209	transmembrane transport
LDN75_RS05485	COG0395	ABC-type sugar transport system, permease component
LDN75_RS05525	COG1472	Belongs to the glycosyl hydrolase 3 family
LDN75_RS05530	COG0673	inositol 2-dehydrogenase activity
LDN75_RS05545	COG1609	Transcriptional regulator
LDN75_RS05560	COG0477	Major facilitator Superfamily
LDN75_RS05575	COG3973	AAA domain
LDN75_RS05580	COG3321	synthase
LDN75_RS05580	COG0604	alcohol dehydrogenase
LDN75_RS05590	COG1309	transcriptional regulator
LDN75_RS05610	COG1131	(ABC) transporter
LDN75_RS05630	COG0640	Transcriptional regulator
LDN75_RS05660	COG1846	Transcriptional regulator
LDN75_RS05665	COG0697	spore germination
LDN75_RS05685	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LDN75_RS05700	COG0531	amino acid
LDN75_RS05710	COG2271	Major facilitator Superfamily
LDN75_RS05755	COG2826	transposase and inactivated derivatives, IS30 family
LDN75_RS05785	COG2957	Belongs to the agmatine deiminase family
LDN75_RS05800	COG1136	(ABC) transporter
LDN75_RS05805	COG0577	efflux transmembrane transporter activity
LDN75_RS05805	COG1136	(ABC) transporter
LDN75_RS05830	COG2072	flavoprotein involved in K transport
LDN75_RS05870	COG4942	peptidase
LDN75_RS05875	COG1278	Cold shock
LDN75_RS05910	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LDN75_RS05945	COG3210	domain, Protein
LDN75_RS05975	COG0484	heat shock protein binding
LDN75_RS05990	COG2268	Band 7 protein
LDN75_RS06020	COG0477	Major facilitator Superfamily
LDN75_RS06025	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LDN75_RS06035	COG0138	bifunctional purine biosynthesis protein purh
LDN75_RS06045	COG2838	Isocitrate dehydrogenase
LDN75_RS06060	COG0673	inositol 2-dehydrogenase activity
LDN75_RS06070	COG1136	(ABC) transporter
LDN75_RS06070	COG0577	efflux transmembrane transporter activity
LDN75_RS06075	COG0577	efflux transmembrane transporter activity
LDN75_RS06075	COG1136	(ABC) transporter
LDN75_RS06080	COG1136	(ABC) transporter
LDN75_RS06095	COG4213	ABC transporter substrate-binding protein
LDN75_RS06105	COG1129	ABC transporter
LDN75_RS06115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LDN75_RS06125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LDN75_RS06130	COG0531	amino acid
LDN75_RS06160	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LDN75_RS06165	COG4585	Histidine kinase
LDN75_RS06170	COG2197	response regulator
LDN75_RS06180	COG1131	(ABC) transporter
LDN75_RS06205	COG0180	Tryptophanyl-tRNA synthetase
LDN75_RS06250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LDN75_RS06265	COG2009	succinate dehydrogenase
LDN75_RS06275	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LDN75_RS06275	COG1473	amidohydrolase
LDN75_RS06280	COG1846	Transcriptional regulator
LDN75_RS06285	COG1764	response to oxidative stress
LDN75_RS06290	COG2130	NADP-dependent
LDN75_RS06295	COG1744	ABC transporter substrate-binding protein PnrA-like
LDN75_RS06300	COG3845	ABC transporter
LDN75_RS06305	COG4603	Belongs to the binding-protein-dependent transport system permease family
LDN75_RS06310	COG1079	Belongs to the binding-protein-dependent transport system permease family
LDN75_RS06330	COG0586	Pfam SNARE associated Golgi protein
LDN75_RS06335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LDN75_RS06345	COG0148	phosphopyruvate hydratase activity
LDN75_RS06370	COG1252	NADH dehydrogenase
LDN75_RS06405	COG0559	Belongs to the binding-protein-dependent transport system permease family
LDN75_RS06415	COG0183	Belongs to the thiolase family
LDN75_RS06420	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LDN75_RS06430	COG2017	converts alpha-aldose to the beta-anomer
LDN75_RS06440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LDN75_RS06450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LDN75_RS06460	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LDN75_RS06470	COG1331	Highly conserved protein containing a thioredoxin domain
LDN75_RS06480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LDN75_RS06485	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LDN75_RS06510	COG0114	fumarate hydratase activity
LDN75_RS06515	COG0288	reversible hydration of carbon dioxide
LDN75_RS06525	COG1494	fructose-1,6-bisphosphatase
LDN75_RS06545	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LDN75_RS06595	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LDN75_RS06600	COG1376	ErfK ybiS ycfS ynhG family protein
LDN75_RS06605	COG1357	PFAM Pentapeptide repeats (8 copies)
LDN75_RS06655	COG0714	Associated with various cellular activities
LDN75_RS06660	COG0084	hydrolase, TatD family'
LDN75_RS06665	COG3583	domain protein
LDN75_RS06670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LDN75_RS06675	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LDN75_RS06680	COG0488	(ABC) transporter
LDN75_RS06685	COG1309	transcriptional regulator
LDN75_RS06695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LDN75_RS06700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LDN75_RS06705	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LDN75_RS06710	COG0193	aminoacyl-tRNA hydrolase activity
LDN75_RS06735	COG0822	iron-sulfur transferase activity
LDN75_RS06740	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LDN75_RS06755	COG0702	epimerase
LDN75_RS06770	COG1215	transferase activity, transferring glycosyl groups
LDN75_RS06785	COG0297	glycogen (starch) synthase activity
LDN75_RS06800	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LDN75_RS06860	COG2814	Major facilitator Superfamily
LDN75_RS06875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LDN75_RS06875	COG1648	precorrin-2 dehydrogenase activity
LDN75_RS06880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LDN75_RS06890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LDN75_RS06895	COG1621	beta-fructofuranosidase activity
LDN75_RS06925	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LDN75_RS06930	COG0446	pyridine nucleotide-disulphide oxidoreductase
LDN75_RS06935	COG0243	molybdopterin cofactor binding
LDN75_RS06940	COG2223	nitrite transmembrane transporter activity
LDN75_RS06945	COG0477	Major facilitator Superfamily
LDN75_RS06950	COG4770	biotin carboxylase activity
LDN75_RS06955	COG0424	maF-like protein
LDN75_RS06965	COG2409	Drug exporters of the RND superfamily
LDN75_RS06980	COG0393	Putative heavy-metal-binding
LDN75_RS06985	COG1823	symporter activity
LDN75_RS07000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LDN75_RS07005	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS07010	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LDN75_RS07010	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LDN75_RS07030	COG0714	Associated with various cellular activities
LDN75_RS07050	COG0631	protein serine/threonine phosphatase activity
LDN75_RS07070	COG1674	ftsk spoiiie
LDN75_RS07075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LDN75_RS07080	COG0483	inositol monophosphate 1-phosphatase activity
LDN75_RS07090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDN75_RS07095	COG1116	anion transmembrane transporter activity
LDN75_RS07100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDN75_RS07115	COG0251	oxidation-reduction process
LDN75_RS07120	COG4565	transcriptional regulatory protein
LDN75_RS07130	COG2851	Citrate transporter
LDN75_RS07135	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LDN75_RS07140	COG0154	amidase activity
LDN75_RS07145	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LDN75_RS07155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LDN75_RS07160	COG4209	transmembrane transport
LDN75_RS07165	COG0395	ABC-type sugar transport system, permease component
LDN75_RS07180	COG0673	inositol 2-dehydrogenase activity
LDN75_RS07190	COG1063	alcohol dehydrogenase
LDN75_RS07195	COG0156	8-amino-7-oxononanoate synthase activity
LDN75_RS07205	COG1228	amidohydrolase
LDN75_RS07210	COG0366	Alpha amylase catalytic
LDN75_RS07210	COG1470	cell adhesion involved in biofilm formation
LDN75_RS07215	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LDN75_RS07220	COG1940	carbohydrate kinase activity
LDN75_RS07255	COG2873	o-acetylhomoserine
LDN75_RS07260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LDN75_RS07295	COG0423	glycine-tRNA ligase activity
LDN75_RS07325	COG0358	DNA primase activity
LDN75_RS07345	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LDN75_RS07350	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LDN75_RS07360	COG2814	Major facilitator Superfamily
LDN75_RS07370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LDN75_RS07390	COG1960	acyl-CoA dehydrogenase activity
LDN75_RS07400	COG0052	Belongs to the universal ribosomal protein uS2 family
LDN75_RS07405	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LDN75_RS07410	COG0528	UMP kinase activity
LDN75_RS07415	COG0233	cytoplasmic translational termination
LDN75_RS07420	COG0575	Belongs to the CDS family
LDN75_RS07435	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LDN75_RS07445	COG3279	Response regulator of the LytR AlgR family
LDN75_RS07450	COG3275	phosphorelay sensor kinase activity
LDN75_RS07460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LDN75_RS07465	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LDN75_RS07465	COG1796	DNA polymerase
LDN75_RS07485	COG1522	sequence-specific DNA binding
LDN75_RS07495	COG0022	dehydrogenase e1 component
LDN75_RS07500	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDN75_RS07505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDN75_RS07525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LDN75_RS07535	COG1960	acyl-CoA dehydrogenase activity
LDN75_RS07560	COG3415	Transposase
LDN75_RS07560	COG2801	Transposase and inactivated derivatives
LDN75_RS07570	COG0673	inositol 2-dehydrogenase activity
LDN75_RS07580	COG1082	Xylose isomerase domain protein TIM barrel
LDN75_RS07585	COG0673	inositol 2-dehydrogenase activity
LDN75_RS07595	COG1175	transmembrane transport
LDN75_RS07600	COG1653	transport
LDN75_RS07605	COG1609	Transcriptional regulator
LDN75_RS07615	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LDN75_RS07620	COG0750	zinc metalloprotease
LDN75_RS07630	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LDN75_RS07655	COG0442	prolyl-tRNA aminoacylation
LDN75_RS07665	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
LDN75_RS07680	COG0779	Required for maturation of 30S ribosomal subunits
LDN75_RS07695	COG0481	GTPase activity
LDN75_RS07695	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LDN75_RS07700	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LDN75_RS07705	COG0590	tRNA wobble adenosine to inosine editing
LDN75_RS07710	COG0436	Aminotransferase
LDN75_RS07715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LDN75_RS07735	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LDN75_RS07740	COG1185	polyribonucleotide nucleotidyltransferase activity
LDN75_RS07745	COG0612	Peptidase, M16
LDN75_RS07775	COG0745	RESPONSE REGULATOR receiver
LDN75_RS07780	COG2205	protein histidine kinase activity
LDN75_RS07800	COG0521	Mo-molybdopterin cofactor biosynthetic process
LDN75_RS07810	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LDN75_RS07835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDN75_RS07840	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LDN75_RS07845	COG1674	ftsk spoiiie
LDN75_RS07855	COG1546	Belongs to the CinA family
LDN75_RS07855	COG1058	Belongs to the CinA family
LDN75_RS07860	COG1396	sequence-specific DNA binding
LDN75_RS07875	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LDN75_RS07880	COG2137	regulation of response to DNA damage stimulus
LDN75_RS07885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LDN75_RS07890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LDN75_RS07895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LDN75_RS07900	COG2813	Specifically methylates the guanine in position
LDN75_RS07905	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LDN75_RS07915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LDN75_RS07920	COG1388	LysM domain
LDN75_RS07925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LDN75_RS07930	COG0131	Imidazoleglycerol-phosphate dehydratase
LDN75_RS07935	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LDN75_RS07945	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LDN75_RS07965	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LDN75_RS07970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LDN75_RS07975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LDN75_RS07980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDN75_RS07990	COG2814	Major facilitator Superfamily
LDN75_RS08025	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LDN75_RS08030	COG0072	phenylalanine-tRNA ligase activity
LDN75_RS08030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDN75_RS08045	COG1136	(ABC) transporter
LDN75_RS08045	COG0577	efflux transmembrane transporter activity
LDN75_RS08075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LDN75_RS08080	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LDN75_RS08085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LDN75_RS08090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LDN75_RS08095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LDN75_RS08100	COG1438	arginine binding
LDN75_RS08105	COG0137	argininosuccinate synthase activity
LDN75_RS08110	COG0165	Argininosuccinate lyase
LDN75_RS08125	COG2094	Belongs to the DNA glycosylase MPG family
LDN75_RS08135	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LDN75_RS08165	COG0647	UMP catabolic process
LDN75_RS08180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LDN75_RS08185	COG0497	DNA recombination
LDN75_RS08190	COG0504	CTP synthase activity
LDN75_RS08220	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LDN75_RS08225	COG2079	MmgE PrpD family protein
LDN75_RS08250	COG3290	protein histidine kinase activity
LDN75_RS08255	COG1301	dicarboxylic acid transport
LDN75_RS08265	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LDN75_RS08270	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LDN75_RS08285	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LDN75_RS08295	COG1160	GTP binding
LDN75_RS08310	COG2814	Major facilitator Superfamily
LDN75_RS08320	COG0509	glycine decarboxylation via glycine cleavage system
LDN75_RS08325	COG1716	ATPase activity
LDN75_RS08350	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LDN75_RS08360	COG1940	carbohydrate kinase activity
LDN75_RS08385	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LDN75_RS08390	COG2815	serine threonine protein kinase
LDN75_RS08390	COG0515	serine threonine protein kinase
LDN75_RS08395	COG3942	CHAP domain
LDN75_RS08395	COG1388	LysM domain
LDN75_RS08405	COG0142	geranyltranstransferase activity
LDN75_RS08415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LDN75_RS08425	COG2001	Belongs to the MraZ family
LDN75_RS08430	COG0275	rRNA processing
LDN75_RS08440	COG0768	penicillin binding
LDN75_RS08445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LDN75_RS08450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LDN75_RS08455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LDN75_RS08460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LDN75_RS08470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LDN75_RS08475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LDN75_RS08485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LDN75_RS08500	COG1799	cell septum assembly
LDN75_RS08515	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LDN75_RS08540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LDN75_RS08545	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LDN75_RS08550	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS08570	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LDN75_RS08575	COG0174	glutamine synthetase
LDN75_RS08580	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LDN75_RS08620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LDN75_RS08625	COG0321	lipoyl(octanoyl) transferase activity
LDN75_RS08635	COG1090	epimerase
LDN75_RS08640	COG0793	Belongs to the peptidase S41A family
LDN75_RS08640	COG4946	Tricorn protease homolog
LDN75_RS08645	COG1764	response to oxidative stress
LDN75_RS08655	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDN75_RS08660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDN75_RS08665	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LDN75_RS08685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LDN75_RS08700	COG2814	Major facilitator Superfamily
LDN75_RS08720	COG1271	oxidase subunit
LDN75_RS08725	COG1294	oxidase, subunit
LDN75_RS08730	COG4988	ABC transporter
LDN75_RS08750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LDN75_RS08755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LDN75_RS08755	COG0045	succinate-CoA ligase (ADP-forming) activity
LDN75_RS08755	COG1042	CoA-binding domain protein
LDN75_RS08770	COG1435	thymidine kinase activity
LDN75_RS08795	COG0756	dUTP diphosphatase activity
LDN75_RS08820	COG0569	domain protein
LDN75_RS08825	COG0531	amino acid
LDN75_RS08830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LDN75_RS08835	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LDN75_RS08840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LDN75_RS08860	COG0667	Aldo Keto reductase
LDN75_RS08865	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDN75_RS08865	COG1024	Enoyl-CoA hydratase
LDN75_RS08870	COG0183	Belongs to the thiolase family
LDN75_RS08900	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LDN75_RS08915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LDN75_RS08935	COG3135	benzoate transporter
LDN75_RS08945	COG0531	amino acid
LDN75_RS09055	COG3547	Transposase (IS116 IS110 IS902 family)
LDN75_RS09090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDN75_RS09095	COG0174	glutamine synthetase
LDN75_RS09105	COG1473	amidohydrolase
LDN75_RS09130	COG0242	peptide deformylase activity
LDN75_RS09135	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LDN75_RS09145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LDN75_RS09165	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LDN75_RS09165	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LDN75_RS09175	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LDN75_RS09180	COG0140	phosphoribosyl-ATP diphosphatase activity
LDN75_RS09185	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LDN75_RS09190	COG0107	imidazoleglycerol-phosphate synthase activity
LDN75_RS09200	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LDN75_RS09220	COG0134	indole-3-glycerol-phosphate synthase activity
LDN75_RS09225	COG0133	tryptophan synthase activity
LDN75_RS09230	COG0159	tryptophan synthase activity
LDN75_RS09235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LDN75_RS09240	COG0067	glutamate synthase
LDN75_RS09240	COG0069	glutamate synthase activity
LDN75_RS09240	COG0070	glutamate synthase
LDN75_RS09330	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LDN75_RS09400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LDN75_RS09430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LDN75_RS09450	COG1414	Transcriptional regulator
LDN75_RS09495	COG1175	transmembrane transport
LDN75_RS09520	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LDN75_RS09525	COG2079	MmgE PrpD family protein
LDN75_RS09530	COG0477	Major facilitator Superfamily
LDN75_RS09535	COG1024	Enoyl-CoA hydratase
LDN75_RS09540	COG1802	Transcriptional regulator
LDN75_RS09650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDN75_RS09655	COG0765	amino acid transport
LDN75_RS09660	COG1126	abc transporter atp-binding protein
LDN75_RS09665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDN75_RS09675	COG0251	oxidation-reduction process
LDN75_RS09685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LDN75_RS09700	COG1178	ABC-type Fe3 transport system permease component
LDN75_RS09705	COG3842	ATPase activity
LDN75_RS09715	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LDN75_RS09720	COG1609	Transcriptional regulator
LDN75_RS09730	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS09735	COG3250	beta-galactosidase activity
LDN75_RS09750	COG0444	Belongs to the ABC transporter superfamily
LDN75_RS09755	COG4172	Belongs to the ABC transporter superfamily
LDN75_RS09765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDN75_RS09770	COG0402	S-adenosylhomocysteine deaminase activity
LDN75_RS09775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LDN75_RS09780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDN75_RS09785	COG0765	amino acid transport
LDN75_RS09790	COG1126	abc transporter atp-binding protein
LDN75_RS09795	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LDN75_RS09805	COG1396	sequence-specific DNA binding
LDN75_RS09810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LDN75_RS09825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LDN75_RS09830	COG0133	tryptophan synthase activity
LDN75_RS09835	COG0159	tryptophan synthase activity
LDN75_RS09845	COG2267	carboxylic ester hydrolase activity
LDN75_RS09850	COG0583	DNA-binding transcription factor activity
LDN75_RS09870	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LDN75_RS09875	COG2814	Major facilitator Superfamily
LDN75_RS09885	COG0028	Belongs to the TPP enzyme family
LDN75_RS09890	COG1396	sequence-specific DNA binding
LDN75_RS09895	COG2902	Dehydrogenase
LDN75_RS09925	COG3250	beta-galactosidase activity
LDN75_RS09930	COG2723	6-phospho-beta-galactosidase activity
LDN75_RS09935	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS09955	COG1309	transcriptional regulator
LDN75_RS09965	COG2211	Major facilitator Superfamily
LDN75_RS09985	COG0673	inositol 2-dehydrogenase activity
LDN75_RS10000	COG1175	transmembrane transport
LDN75_RS10005	COG1653	transport
LDN75_RS10030	COG3708	Transcriptional regulator
LDN75_RS10030	COG2207	Transcriptional regulator
LDN75_RS10035	COG1309	transcriptional regulator
LDN75_RS10040	COG0183	Belongs to the thiolase family
LDN75_RS10045	COG2050	protein possibly involved in aromatic compounds catabolism
LDN75_RS10050	COG1902	pentaerythritol trinitrate reductase activity
LDN75_RS10050	COG0446	pyridine nucleotide-disulphide oxidoreductase
LDN75_RS10060	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDN75_RS10065	COG1129	ABC transporter
LDN75_RS10070	COG1879	ABC-type sugar transport system periplasmic component
LDN75_RS10090	COG2423	ornithine cyclodeaminase activity
LDN75_RS10100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDN75_RS10110	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDN75_RS10130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDN75_RS10160	COG1309	transcriptional regulator
LDN75_RS10190	COG1609	Transcriptional regulator
LDN75_RS10200	COG0395	ABC-type sugar transport system, permease component
LDN75_RS10205	COG1175	transmembrane transport
LDN75_RS10245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LDN75_RS10260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDN75_RS10265	COG0765	amino acid transport
LDN75_RS10275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDN75_RS10285	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LDN75_RS10315	COG1609	Transcriptional regulator
LDN75_RS10375	COG0395	ABC-type sugar transport system, permease component
LDN75_RS10380	COG4209	transmembrane transport
LDN75_RS10395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LDN75_RS10400	COG3250	beta-galactosidase activity
LDN75_RS10410	COG1609	Transcriptional regulator
LDN75_RS10420	COG1349	DNA-binding transcription factor activity
LDN75_RS10430	COG3842	ATPase activity
LDN75_RS10435	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LDN75_RS10440	COG1176	ABC-type spermidine putrescine transport system, permease component I
LDN75_RS10445	COG1177	transmembrane transport
LDN75_RS10450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LDN75_RS10460	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LDN75_RS10490	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LDN75_RS10525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDN75_RS10535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDN75_RS10540	COG0601	transmembrane transport
LDN75_RS10545	COG0747	negative chemotaxis
LDN75_RS10550	COG2897	thiosulfate sulfurtransferase activity
LDN75_RS10580	COG3547	Transposase (IS116 IS110 IS902 family)
LDN75_RS10585	COG2986	histidine ammonia-lyase
LDN75_RS10590	COG0477	Major facilitator Superfamily
LDN75_RS10600	COG2986	histidine ammonia-lyase
LDN75_RS10610	COG1174	glycine betaine transport
LDN75_RS10620	COG1125	glycine betaine transport
LDN75_RS10620	COG0517	IMP dehydrogenase activity
LDN75_RS10635	COG1960	acyl-CoA dehydrogenase activity
LDN75_RS10655	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LDN75_RS10685	COG3328	transposase activity
LDN75_RS10710	COG3401	FG-GAP repeat protein
LDN75_RS10725	COG0110	maltose O-acetyltransferase activity
LDN75_RS10735	COG1175	transmembrane transport
LDN75_RS10740	COG0395	ABC-type sugar transport system, permease component
LDN75_RS10750	COG3458	cephalosporin-C deacetylase activity
LDN75_RS10765	COG0246	Mannitol dehydrogenase
LDN75_RS10770	COG0800	Aldolase
LDN75_RS10775	COG1904	glucuronate isomerase
LDN75_RS10780	COG1175	transmembrane transport
LDN75_RS10785	COG0395	ABC-type sugar transport system, permease component
LDN75_RS10805	COG3842	ATPase activity
LDN75_RS10815	COG1176	ABC-type spermidine putrescine transport system, permease component I
LDN75_RS10875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LDN75_RS10880	COG3250	beta-galactosidase activity
LDN75_RS10890	COG1609	Transcriptional regulator
LDN75_RS10900	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LDN75_RS10905	COG0701	Predicted permease
LDN75_RS10915	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LDN75_RS10920	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LDN75_RS10925	COG0765	amino acid transport
LDN75_RS10930	COG0765	amino acid transport
LDN75_RS10935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDN75_RS10940	COG1126	abc transporter atp-binding protein
LDN75_RS10965	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LDN75_RS10970	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LDN75_RS10975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDN75_RS10985	COG1012	belongs to the aldehyde dehydrogenase family
LDN75_RS10995	COG2076	Multidrug Resistance protein
LDN75_RS11000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDN75_RS11010	COG1012	belongs to the aldehyde dehydrogenase family
LDN75_RS11030	COG0596	Alpha beta hydrolase
LDN75_RS11045	COG3104	oligopeptide transport
LDN75_RS11055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDN75_RS11055	COG0723	plastoquinol--plastocyanin reductase activity
LDN75_RS11090	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDN75_RS11095	COG0022	dehydrogenase e1 component
LDN75_RS11105	COG1802	Transcriptional regulator
LDN75_RS11130	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS11145	COG1454	alcohol dehydrogenase
LDN75_RS11160	COG1960	acyl-CoA dehydrogenase activity
LDN75_RS11180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LDN75_RS11190	COG0022	dehydrogenase e1 component
LDN75_RS11200	COG2826	transposase and inactivated derivatives, IS30 family
LDN75_RS11270	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LDN75_RS11280	COG1012	belongs to the aldehyde dehydrogenase family
LDN75_RS11320	COG3408	Glycogen debranching enzyme
LDN75_RS11325	COG1609	Transcriptional regulator
LDN75_RS11335	COG0583	DNA-binding transcription factor activity
LDN75_RS11345	COG1012	belongs to the aldehyde dehydrogenase family
LDN75_RS11350	COG0477	Major facilitator Superfamily
LDN75_RS11370	COG2902	Dehydrogenase
LDN75_RS11375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDN75_RS11385	COG4166	transmembrane transport
LDN75_RS11415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDN75_RS11425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LDN75_RS11445	COG3654	unkown
LDN75_RS11460	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDN75_RS11465	COG0022	dehydrogenase e1 component
LDN75_RS11480	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LDN75_RS11495	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LDN75_RS11505	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LDN75_RS11515	COG1126	abc transporter atp-binding protein
LDN75_RS11525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDN75_RS11550	COG0165	Argininosuccinate lyase
LDN75_RS11560	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS11565	COG3250	beta-galactosidase activity
LDN75_RS11580	COG0444	Belongs to the ABC transporter superfamily
LDN75_RS11600	COG1609	Transcriptional regulator
LDN75_RS11605	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS11610	COG2723	6-phospho-beta-galactosidase activity
LDN75_RS11615	COG3250	beta-galactosidase activity
LDN75_RS11630	COG1609	Transcriptional regulator
LDN75_RS11640	COG2072	flavoprotein involved in K transport
LDN75_RS11655	COG0800	Aldolase
LDN75_RS11675	COG1063	alcohol dehydrogenase
LDN75_RS11690	COG0148	phosphopyruvate hydratase activity
LDN75_RS11695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDN75_RS11725	COG1609	Transcriptional regulator
LDN75_RS11730	COG2814	Major facilitator Superfamily
LDN75_RS11745	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDN75_RS11745	COG1024	Enoyl-CoA hydratase
LDN75_RS11750	COG0183	Belongs to the thiolase family
LDN75_RS11850	COG1621	beta-fructofuranosidase activity
LDN75_RS11855	COG1621	beta-fructofuranosidase activity
LDN75_RS11880	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LDN75_RS11895	COG0800	Aldolase
LDN75_RS11905	COG1609	Transcriptional regulator
LDN75_RS11930	COG0673	inositol 2-dehydrogenase activity
LDN75_RS11935	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS11945	COG0395	ABC-type sugar transport system, permease component
LDN75_RS11965	COG1760	l-serine dehydratase
LDN75_RS11980	COG2814	Major facilitator Superfamily
LDN75_RS12000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDN75_RS12005	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LDN75_RS12030	COG3962	Belongs to the TPP enzyme family
LDN75_RS12035	COG1012	belongs to the aldehyde dehydrogenase family
LDN75_RS12040	COG0673	inositol 2-dehydrogenase activity
LDN75_RS12045	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS12050	COG0129	dihydroxy-acid dehydratase activity
LDN75_RS12055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDN75_RS12065	COG0673	inositol 2-dehydrogenase activity
LDN75_RS12070	COG1129	ABC transporter
LDN75_RS12075	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDN75_RS12085	COG0277	FAD linked oxidase domain protein
LDN75_RS12085	COG0247	lactate metabolic process
LDN75_RS12090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDN75_RS12165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDN75_RS12170	COG1733	regulation of RNA biosynthetic process
LDN75_RS12190	COG0477	Major facilitator Superfamily
LDN75_RS12205	COG2814	Major facilitator Superfamily
LDN75_RS12220	COG2207	Transcriptional regulator
LDN75_RS12245	COG0604	alcohol dehydrogenase
LDN75_RS12255	COG2271	Major facilitator Superfamily
LDN75_RS12275	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LDN75_RS12280	COG0583	DNA-binding transcription factor activity
LDN75_RS12285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDN75_RS12290	COG1116	anion transmembrane transporter activity
LDN75_RS12305	COG1082	Xylose isomerase domain protein TIM barrel
LDN75_RS12310	COG0673	inositol 2-dehydrogenase activity
LDN75_RS12315	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LDN75_RS12320	COG1063	alcohol dehydrogenase
LDN75_RS12365	COG1129	ABC transporter
LDN75_RS12370	COG1172	Belongs to the binding-protein-dependent transport system permease family
LDN75_RS12380	COG5564	TIM-barrel signal transduction protein
LDN75_RS12405	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LDN75_RS12410	COG2079	MmgE PrpD family protein
LDN75_RS12420	COG0477	Major facilitator Superfamily
LDN75_RS12455	COG1960	acyl-CoA dehydrogenase activity
LDN75_RS12495	COG1063	alcohol dehydrogenase
LDN75_RS12525	COG3619	membrane
LDN75_RS12530	COG2188	Transcriptional regulator
LDN75_RS12535	COG0405	Gamma-glutamyltransferase
LDN75_RS12540	COG1522	sequence-specific DNA binding
LDN75_RS12555	COG0022	dehydrogenase e1 component
LDN75_RS12560	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDN75_RS12570	COG1960	acyl-CoA dehydrogenase activity
LDN75_RS12580	COG0183	Belongs to the thiolase family
LDN75_RS12590	COG2271	Major facilitator Superfamily
LDN75_RS12600	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LDN75_RS12635	COG2159	amidohydrolase
LDN75_RS12640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDN75_RS12650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LDN75_RS12655	COG1012	belongs to the aldehyde dehydrogenase family
LDN75_RS12670	COG1129	ABC transporter
LDN75_RS12700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LDN75_RS12755	COG1131	(ABC) transporter
LDN75_RS12775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LDN75_RS12775	COG0574	Belongs to the PEP-utilizing enzyme family
LDN75_RS12800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LDN75_RS12835	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LDN75_RS12870	COG2217	Heavy metal translocating P-type atpase
LDN75_RS12880	COG0857	belongs to the CobB CobQ family
LDN75_RS12880	COG0280	phosphate acetyltransferase
LDN75_RS12890	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LDN75_RS12905	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LDN75_RS12910	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LDN75_RS12915	COG2132	Multicopper oxidase
LDN75_RS12925	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS12940	COG0477	Major facilitator Superfamily
LDN75_RS12950	COG1902	pentaerythritol trinitrate reductase activity
LDN75_RS12970	COG2814	Major facilitator Superfamily
LDN75_RS12975	COG1012	belongs to the aldehyde dehydrogenase family
LDN75_RS13005	COG1309	transcriptional regulator
LDN75_RS13010	COG0110	maltose O-acetyltransferase activity
LDN75_RS13015	COG3226	Transcriptional regulator
LDN75_RS13020	COG3226	Transcriptional regulator
LDN75_RS13030	COG0028	Belongs to the TPP enzyme family
LDN75_RS13045	COG3833	ABC-type maltose transport systems, permease component
LDN75_RS13050	COG0395	ABC-type sugar transport system, permease component
LDN75_RS13055	COG0583	DNA-binding transcription factor activity
LDN75_RS13060	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LDN75_RS13080	COG0738	Major facilitator superfamily
LDN75_RS13095	COG3123	guanosine phosphorylase activity
LDN75_RS13125	COG0028	Belongs to the TPP enzyme family
LDN75_RS13130	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LDN75_RS13140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LDN75_RS13150	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS13165	COG0583	DNA-binding transcription factor activity
LDN75_RS13195	COG0028	Belongs to the TPP enzyme family
LDN75_RS13265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LDN75_RS13275	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LDN75_RS13285	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDN75_RS13295	COG0022	dehydrogenase e1 component
LDN75_RS13310	COG2186	Transcriptional regulator
LDN75_RS13315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LDN75_RS13325	COG1960	acyl-CoA dehydrogenase activity
LDN75_RS13340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LDN75_RS13350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LDN75_RS13355	COG3424	synthase
LDN75_RS13360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LDN75_RS13375	COG0242	peptide deformylase activity
LDN75_RS13380	COG0823	Involved in the tonB-independent uptake of proteins
LDN75_RS13380	COG1506	peptidase
LDN75_RS13380	COG4946	Tricorn protease homolog
LDN75_RS13385	COG2226	methyltransferase
LDN75_RS13405	COG1216	Glycosyl transferase, family 2
LDN75_RS13410	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LDN75_RS13415	COG4581	dead DEAH box helicase
LDN75_RS13420	COG0805	protein transport
LDN75_RS13425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LDN75_RS13445	COG0545	Peptidyl-prolyl cis-trans isomerase
LDN75_RS13450	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LDN75_RS13455	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LDN75_RS13460	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LDN75_RS13470	COG4122	O-methyltransferase activity
LDN75_RS13475	COG1222	aaa ATPase
LDN75_RS13485	COG1994	Peptidase M50
LDN75_RS13485	COG0517	IMP dehydrogenase activity
LDN75_RS13490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDN75_RS13500	COG0215	cysteine-tRNA ligase activity
LDN75_RS13505	COG1968	undecaprenyl-diphosphatase activity
LDN75_RS13510	COG0656	L-ascorbic acid biosynthetic process
LDN75_RS13515	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LDN75_RS13520	COG1088	dTDP-glucose 4,6-dehydratase activity
LDN75_RS13580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LDN75_RS13595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LDN75_RS13640	COG0183	Belongs to the thiolase family
LDN75_RS13655	COG0297	glycogen (starch) synthase activity
LDN75_RS13660	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LDN75_RS13685	COG2855	membrane
LDN75_RS13700	COG0254	rRNA binding
LDN75_RS13715	COG1119	ATPase activity
LDN75_RS13720	COG0560	Phosphoserine phosphatase
LDN75_RS13720	COG3830	Belongs to the UPF0237 family
LDN75_RS13740	COG1129	ABC transporter
LDN75_RS13745	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS13750	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS13775	COG0488	(ABC) transporter
LDN75_RS13780	COG1268	BioY protein
LDN75_RS13785	COG1122	ATPase activity
LDN75_RS13800	COG0318	PFAM AMP-dependent synthetase and ligase
LDN75_RS13810	COG2151	metal-sulfur cluster biosynthetic enzyme
LDN75_RS13815	COG0396	ATPase activity
LDN75_RS13825	COG0719	Fe-S assembly protein
LDN75_RS13840	COG1131	(ABC) transporter
LDN75_RS13850	COG1612	heme a metabolic process
LDN75_RS13855	COG0109	protoheme IX farnesyltransferase activity
LDN75_RS13865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LDN75_RS13870	COG0166	Belongs to the GPI family
LDN75_RS13885	COG0363	glucosamine-6-phosphate deaminase activity
LDN75_RS13895	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LDN75_RS13900	COG0149	triose-phosphate isomerase activity
LDN75_RS13905	COG0126	phosphoglycerate kinase activity
LDN75_RS13910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LDN75_RS13915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LDN75_RS13920	COG1481	regulation of sporulation
LDN75_RS13930	COG1660	Displays ATPase and GTPase activities
LDN75_RS13935	COG0322	excinuclease ABC activity
LDN75_RS13945	COG0546	phosphoglycolate phosphatase activity
LDN75_RS13960	COG4106	trans-aconitate 2-methyltransferase activity
LDN75_RS13970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDN75_RS13995	COG0556	nucleotide-excision repair
LDN75_RS14000	COG0237	dephospho-CoA kinase activity
LDN75_RS14000	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LDN75_RS14005	COG1739	Uncharacterized protein family UPF0029
LDN75_RS14010	COG0539	negative regulation of cytoplasmic translation
LDN75_RS14020	COG4552	Acetyltransferase involved in intracellular survival and related
LDN75_RS14030	COG2050	protein possibly involved in aromatic compounds catabolism
LDN75_RS14065	COG3483	tryptophan 2,3-dioxygenase activity
LDN75_RS14080	COG2188	Transcriptional regulator
LDN75_RS14085	COG2814	Major facilitator Superfamily
LDN75_RS14090	COG2971	BadF BadG BcrA BcrD
LDN75_RS14095	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LDN75_RS14115	COG0009	L-threonylcarbamoyladenylate synthase
LDN75_RS14150	COG1113	amino acid transport
LDN75_RS14155	COG1228	amidohydrolase
LDN75_RS14160	COG1643	Atp-dependent helicase
LDN75_RS14165	COG1064	alcohol dehydrogenase
LDN75_RS14190	COG4941	Belongs to the sigma-70 factor family
LDN75_RS14195	COG3795	YCII-related domain
LDN75_RS14205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LDN75_RS14225	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LDN75_RS14270	COG1012	belongs to the aldehyde dehydrogenase family
LDN75_RS14290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDN75_RS14295	COG0028	Belongs to the TPP enzyme family
LDN75_RS14300	COG3285	dna ligase
LDN75_RS14300	COG1793	dna ligase
LDN75_RS14320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LDN75_RS14325	COG1845	cytochrome c oxidase, subunit III
LDN75_RS14330	COG2010	Cytochrome c
LDN75_RS14335	COG0723	plastoquinol--plastocyanin reductase activity
LDN75_RS14340	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LDN75_RS14345	COG2188	Transcriptional regulator
LDN75_RS14350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDN75_RS14360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LDN75_RS14365	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LDN75_RS14385	COG0167	dihydroorotate dehydrogenase activity
LDN75_RS14400	COG2226	methyltransferase
LDN75_RS14400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LDN75_RS14400	COG0596	Alpha beta hydrolase
LDN75_RS14405	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LDN75_RS14410	COG1381	Involved in DNA repair and RecF pathway recombination
LDN75_RS14415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LDN75_RS14420	COG3590	peptidase
LDN75_RS14425	COG1316	TRANSCRIPTIONal
LDN75_RS14430	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LDN75_RS14440	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LDN75_RS14455	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LDN75_RS14460	COG0484	heat shock protein binding
LDN75_RS14465	COG1420	regulation of RNA biosynthetic process
LDN75_RS14485	COG0481	GTPase activity
LDN75_RS14495	COG0268	Binds directly to 16S ribosomal RNA
LDN75_RS14515	COG1307	EDD domain protein, DegV family
LDN75_RS14520	COG0495	leucyl-tRNA aminoacylation
LDN75_RS14525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LDN75_RS14530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LDN75_RS14535	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LDN75_RS14540	COG2390	Transcriptional regulator
LDN75_RS14545	COG0656	L-ascorbic acid biosynthetic process
LDN75_RS14565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LDN75_RS14575	COG1758	RNA polymerase activity
LDN75_RS14580	COG0194	GDP metabolic process
LDN75_RS14590	COG0284	orotidine-5'-phosphate decarboxylase activity
LDN75_RS14595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LDN75_RS14600	COG0505	Belongs to the CarA family
LDN75_RS14610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LDN75_RS14615	COG0540	Belongs to the ATCase OTCase family
LDN75_RS14620	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LDN75_RS14630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LDN75_RS14635	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LDN75_RS14645	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LDN75_RS14650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LDN75_RS14655	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LDN75_RS14660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDN75_RS14675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LDN75_RS14690	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LDN75_RS14710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LDN75_RS14715	COG0124	histidyl-tRNA synthetase
LDN75_RS14725	COG1196	nuclear chromosome segregation
LDN75_RS14735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LDN75_RS14740	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LDN75_RS14745	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LDN75_RS14755	COG2255	four-way junction helicase activity
LDN75_RS14760	COG0632	four-way junction helicase activity
LDN75_RS14765	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LDN75_RS14770	COG0217	transcriptional regulatory protein
LDN75_RS14775	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LDN75_RS14780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LDN75_RS14800	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LDN75_RS14805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LDN75_RS14815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LDN75_RS14820	COG0587	DNA-directed DNA polymerase activity
LDN75_RS14845	COG2135	peptidase activity
LDN75_RS14860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDN75_RS14890	COG0723	plastoquinol--plastocyanin reductase activity
LDN75_RS14900	COG4804	nuclease activity
LDN75_RS14915	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LDN75_RS14925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LDN75_RS14930	COG1780	Probably involved in ribonucleotide reductase function
LDN75_RS14940	COG0583	DNA-binding transcription factor activity
LDN75_RS14955	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LDN75_RS14985	COG0714	Associated with various cellular activities
LDN75_RS14995	COG3833	ABC-type maltose transport systems, permease component
LDN75_RS15000	COG1175	transmembrane transport
LDN75_RS15015	COG2813	Specifically methylates the guanine in position
LDN75_RS15040	COG0799	negative regulation of ribosome biogenesis
LDN75_RS15050	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LDN75_RS15060	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LDN75_RS15065	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LDN75_RS15070	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LDN75_RS15075	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LDN75_RS15080	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LDN75_RS15085	COG0352	thiamine-phosphate diphosphorylase activity
LDN75_RS15085	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LDN75_RS15085	COG0351	phosphomethylpyrimidine kinase
LDN75_RS15090	COG1530	ribonuclease E activity
LDN75_RS15100	COG2801	Transposase and inactivated derivatives
LDN75_RS15100	COG3415	Transposase
LDN75_RS15105	COG0105	UTP biosynthetic process
LDN75_RS15115	COG0285	dihydrofolate synthase activity
LDN75_RS15120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LDN75_RS15135	COG3189	MarR family transcriptional regulator
LDN75_RS15140	COG0525	valine-tRNA ligase activity
LDN75_RS15145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LDN75_RS15150	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LDN75_RS15155	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LDN75_RS15160	COG0740	serine-type endopeptidase activity
LDN75_RS15165	COG0740	serine-type endopeptidase activity
LDN75_RS15170	COG0544	peptidyl-prolyl cis-trans isomerase activity
LDN75_RS15205	COG2801	Transposase and inactivated derivatives
LDN75_RS15205	COG3415	Transposase
LDN75_RS15220	COG0668	transmembrane transport
LDN75_RS15235	COG1946	Acyl-CoA thioesterase
LDN75_RS15265	COG0629	single-stranded DNA binding
LDN75_RS15300	COG0242	peptide deformylase activity
LDN75_RS15330	COG3022	response to hydroperoxide
LDN75_RS15340	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LDN75_RS15345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LDN75_RS15355	COG1045	serine acetyltransferase
LDN75_RS15360	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS15365	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LDN75_RS15375	COG1063	alcohol dehydrogenase
LDN75_RS15380	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS15395	COG0477	Major facilitator Superfamily
LDN75_RS15430	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LDN75_RS15445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LDN75_RS15450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LDN75_RS15465	COG4974	Belongs to the 'phage' integrase family
LDN75_RS15480	COG0792	nuclease activity
LDN75_RS15490	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LDN75_RS15500	COG0681	Belongs to the peptidase S26 family
LDN75_RS15505	COG0335	large ribosomal subunit rRNA binding
LDN75_RS15510	COG0336	Belongs to the RNA methyltransferase TrmD family
LDN75_RS15515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LDN75_RS15520	COG1837	Belongs to the UPF0109 family
LDN75_RS15525	COG0228	four-way junction DNA binding
LDN75_RS15535	COG2514	catechol 2,3-dioxygenase activity
LDN75_RS15560	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LDN75_RS15575	COG2814	Major facilitator Superfamily
LDN75_RS15615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LDN75_RS15620	COG0571	ribonuclease III activity
LDN75_RS15625	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LDN75_RS15635	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LDN75_RS15650	COG0742	ribosomal rna small subunit methyltransferase
LDN75_RS15675	COG1181	Belongs to the D-alanine--D-alanine ligase family
LDN75_RS15680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LDN75_RS15690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LDN75_RS15695	COG0066	3-isopropylmalate dehydratase activity
LDN75_RS15700	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LDN75_RS15705	COG1414	Transcriptional regulator
LDN75_RS15740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LDN75_RS15745	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDN75_RS15750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDN75_RS15755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LDN75_RS15760	COG0473	3-isopropylmalate dehydrogenase activity
LDN75_RS15765	COG4585	Histidine kinase
LDN75_RS15770	COG2197	response regulator
LDN75_RS15775	COG0577	efflux transmembrane transporter activity
LDN75_RS15775	COG1136	(ABC) transporter
LDN75_RS15790	COG0577	efflux transmembrane transporter activity
LDN75_RS15790	COG1136	(ABC) transporter
LDN75_RS15800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDN75_RS15805	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LDN75_RS15810	COG0440	acetolactate synthase activity
LDN75_RS15820	COG0129	dihydroxy-acid dehydratase activity
LDN75_RS15825	COG0088	Forms part of the polypeptide exit tunnel
LDN75_RS15830	COG2133	pyrroloquinoline quinone binding
LDN75_RS15860	COG0747	negative chemotaxis
LDN75_RS15865	COG0579	oxidoreductase
LDN75_RS15870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LDN75_RS15875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDN75_RS15885	COG1305	Transglutaminase-like
LDN75_RS15915	COG1104	cysteine desulfurase activity
LDN75_RS15925	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LDN75_RS15930	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LDN75_RS15940	COG1522	sequence-specific DNA binding
LDN75_RS15945	COG1113	amino acid transport
LDN75_RS15955	COG0022	dehydrogenase e1 component
LDN75_RS15960	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDN75_RS15980	COG0477	Major facilitator Superfamily
LDN75_RS16005	COG3119	arylsulfatase activity
LDN75_RS16010	COG1116	anion transmembrane transporter activity
LDN75_RS16015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDN75_RS16025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LDN75_RS16045	COG0419	ATPase involved in DNA repair
LDN75_RS16050	COG0420	3'-5' exonuclease activity
LDN75_RS16065	COG2149	membrane
LDN75_RS16085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LDN75_RS16090	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LDN75_RS16095	COG1234	tRNA 3'-trailer cleavage
LDN75_RS16100	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LDN75_RS16110	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LDN75_RS16120	COG1335	isochorismatase
LDN75_RS16135	COG0363	glucosamine-6-phosphate deaminase activity
LDN75_RS16150	COG1902	pentaerythritol trinitrate reductase activity
LDN75_RS16165	COG0628	permease
LDN75_RS16180	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
LDN75_RS16195	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LDN75_RS16200	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LDN75_RS16210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LDN75_RS16215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LDN75_RS16220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LDN75_RS16225	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LDN75_RS16230	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LDN75_RS16235	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LDN75_RS16240	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LDN75_RS16245	COG0356	it plays a direct role in the translocation of protons across the membrane
LDN75_RS16280	COG2890	protein-(glutamine-N5) methyltransferase activity
LDN75_RS16285	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LDN75_RS16295	COG0083	homoserine kinase activity
LDN75_RS16300	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LDN75_RS16305	COG0460	homoserine dehydrogenase
LDN75_RS16310	COG0019	diaminopimelate decarboxylase activity
LDN75_RS16315	COG0018	arginyl-trna synthetase
LDN75_RS16330	COG1017	nitric oxide dioxygenase activity
LDN75_RS16330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDN75_RS16360	COG1643	Atp-dependent helicase
LDN75_RS16365	COG0537	adenosine 5'-monophosphoramidase activity
LDN75_RS16370	COG1064	alcohol dehydrogenase
LDN75_RS16395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LDN75_RS16400	COG1121	(ABC) transporter
LDN75_RS16415	COG1253	flavin adenine dinucleotide binding
LDN75_RS16420	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDN75_RS16420	COG0567	Dehydrogenase, E1 component
LDN75_RS16450	COG1595	DNA-templated transcription, initiation
LDN75_RS16460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LDN75_RS16470	COG0483	inositol monophosphate 1-phosphatase activity
LDN75_RS16475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LDN75_RS16500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LDN75_RS16505	COG3415	Transposase
LDN75_RS16505	COG2801	Transposase and inactivated derivatives
LDN75_RS16515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LDN75_RS16525	COG2177	Part of the ABC transporter FtsEX involved in
LDN75_RS16530	COG2884	Cell division ATP-binding protein ftsE
LDN75_RS16535	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LDN75_RS16625	COG1216	Glycosyl transferase, family 2
LDN75_RS16640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LDN75_RS16670	COG2902	Dehydrogenase
LDN75_RS16700	COG0653	protein targeting
LDN75_RS16705	COG3214	Protein conserved in bacteria
LDN75_RS16710	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LDN75_RS16720	COG5401	PFAM Sporulation and spore germination
LDN75_RS16725	COG5002	protein histidine kinase activity
LDN75_RS16730	COG0745	RESPONSE REGULATOR receiver
LDN75_RS16750	COG0714	Associated with various cellular activities
LDN75_RS16790	COG0601	transmembrane transport
LDN75_RS16810	COG0482	sulfurtransferase activity
LDN75_RS16845	COG0484	heat shock protein binding
LDN75_RS16850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LDN75_RS16870	COG3265	gluconokinase activity
LDN75_RS16875	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LDN75_RS16880	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LDN75_RS16885	COG2086	electron transfer activity
LDN75_RS16890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LDN75_RS16900	COG1842	Phage shock protein A
LDN75_RS16905	COG2188	Transcriptional regulator
LDN75_RS16920	COG1615	UPF0182 protein
LDN75_RS16925	COG3480	Lon protease (S16) C-terminal proteolytic domain
LDN75_RS16945	COG2816	NAD+ diphosphatase activity
LDN75_RS16975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDN75_RS16980	COG0765	amino acid transport
LDN75_RS16985	COG1126	abc transporter atp-binding protein
LDN75_RS16990	COG1472	Belongs to the glycosyl hydrolase 3 family
LDN75_RS16995	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LDN75_RS17005	COG0113	porphobilinogen synthase activity
LDN75_RS17015	COG0181	hydroxymethylbilane synthase activity
LDN75_RS17020	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LDN75_RS17025	COG3253	May function as heme-dependent peroxidase
LDN75_RS17030	COG1231	oxidoreductase activity
LDN75_RS17035	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LDN75_RS17040	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LDN75_RS17055	COG1309	transcriptional regulator
LDN75_RS17085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDN75_RS17085	COG2022	thiamine diphosphate biosynthetic process
LDN75_RS17090	COG0352	thiamine-phosphate diphosphorylase activity
LDN75_RS17105	COG0513	Belongs to the DEAD box helicase family
LDN75_RS17125	COG0006	proline dipeptidase activity
LDN75_RS17135	COG2239	Acts as a magnesium transporter
LDN75_RS17150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LDN75_RS17160	COG1595	DNA-templated transcription, initiation
LDN75_RS17190	COG1126	abc transporter atp-binding protein
LDN75_RS17195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDN75_RS17200	COG0765	amino acid transport
LDN75_RS17205	COG0765	amino acid transport
LDN75_RS17210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDN75_RS17215	COG2171	N-acyltransferase activity
LDN75_RS17230	COG3226	Transcriptional regulator
LDN75_RS17235	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LDN75_RS17260	COG1217	gtp-binding protein TYPA
LDN75_RS17275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDN75_RS17280	COG0601	transmembrane transport
LDN75_RS17290	COG0012	GTP binding
LDN75_RS17295	COG1322	Protein conserved in bacteria
LDN75_RS17300	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LDN75_RS17310	COG1570	exodeoxyribonuclease VII activity
LDN75_RS17315	COG1722	exodeoxyribonuclease VII activity
LDN75_RS17320	COG2326	polyphosphate kinase activity
LDN75_RS17340	COG1174	glycine betaine transport
LDN75_RS17350	COG1162	GTPase activity
LDN75_RS17370	COG2971	BadF BadG BcrA BcrD
LDN75_RS17375	COG2070	2-Nitropropane dioxygenase
LDN75_RS17380	COG0583	DNA-binding transcription factor activity
LDN75_RS17385	COG2814	Major facilitator Superfamily
LDN75_RS17410	COG0598	Magnesium transport protein CorA
LDN75_RS17420	COG1528	Iron-storage protein
LDN75_RS17425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LDN75_RS17430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LDN75_RS17440	COG2824	Alkylphosphonate utilization operon protein PhnA
LDN75_RS17445	COG1278	Cold shock
LDN75_RS17470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LDN75_RS17475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LDN75_RS17495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LDN75_RS17495	COG0519	Catalyzes the synthesis of GMP from XMP
LDN75_RS17515	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LDN75_RS17520	COG0516	GMP reductase activity
LDN75_RS17525	COG1132	(ABC) transporter
LDN75_RS17545	COG2072	flavoprotein involved in K transport
LDN75_RS17555	COG2197	response regulator
LDN75_RS17560	COG0459	protein refolding
LDN75_RS17565	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LDN75_RS17580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDN75_RS17585	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LDN75_RS17595	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LDN75_RS17600	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LDN75_RS17605	COG0456	acetyltransferase
LDN75_RS17615	COG0802	atpase or kinase
LDN75_RS17620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LDN75_RS17630	COG1486	melibiose metabolic process
LDN75_RS17640	COG0438	transferase activity, transferring glycosyl groups
LDN75_RS17645	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LDN75_RS17655	COG0667	Aldo Keto reductase
LDN75_RS17680	COG0736	holo-[acyl-carrier-protein] synthase activity
LDN75_RS17690	COG1072	(Pantothenic acid kinase))
LDN75_RS17700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LDN75_RS17705	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LDN75_RS17710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LDN75_RS17740	COG0455	bacterial-type flagellum organization
LDN75_RS17760	COG0101	tRNA pseudouridine synthase activity
LDN75_RS17765	COG0203	ribosomal protein L17
LDN75_RS17770	COG0202	RNA polymerase activity
LDN75_RS17775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LDN75_RS17780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LDN75_RS17785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LDN75_RS17790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LDN75_RS17795	COG3191	aminopeptidase activity
LDN75_RS17805	COG0747	negative chemotaxis
LDN75_RS17810	COG4172	Belongs to the ABC transporter superfamily
LDN75_RS17815	COG0444	Belongs to the ABC transporter superfamily
LDN75_RS17820	COG0601	transmembrane transport
LDN75_RS17825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDN75_RS17835	COG2186	Transcriptional regulator
LDN75_RS17840	COG1228	amidohydrolase
LDN75_RS17855	COG0318	PFAM AMP-dependent synthetase and ligase
LDN75_RS17870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LDN75_RS17875	COG0563	adenylate kinase activity
LDN75_RS17885	COG0200	Binds to the 23S rRNA
LDN75_RS17890	COG1841	ribosomal large subunit assembly
LDN75_RS17895	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LDN75_RS17905	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LDN75_RS17910	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LDN75_RS17915	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LDN75_RS17920	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LDN75_RS17925	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LDN75_RS17930	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LDN75_RS17940	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LDN75_RS17945	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LDN75_RS17950	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LDN75_RS17955	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LDN75_RS17960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LDN75_RS17965	COG0089	rRNA binding
LDN75_RS17970	COG0088	Forms part of the polypeptide exit tunnel
LDN75_RS17975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LDN75_RS17980	COG0051	transcription antitermination factor activity, RNA binding
LDN75_RS17995	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LDN75_RS18000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LDN75_RS18005	COG0049	tRNA binding
LDN75_RS18010	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LDN75_RS18015	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LDN75_RS18020	COG0085	RNA polymerase activity
LDN75_RS18025	COG0183	Belongs to the thiolase family
LDN75_RS18030	COG0442	prolyl-tRNA aminoacylation
LDN75_RS18035	COG0222	ribosome binding
LDN75_RS18040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LDN75_RS18055	COG0081	regulation of translation
LDN75_RS18060	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LDN75_RS18080	COG0436	Aminotransferase
LDN75_RS18085	COG2197	response regulator
LDN75_RS18130	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LDN75_RS18140	COG3485	protocatechuate 3,4-dioxygenase
LDN75_RS18150	COG0745	RESPONSE REGULATOR receiver
LDN75_RS18155	COG0456	acetyltransferase
LDN75_RS18160	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LDN75_RS18170	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LDN75_RS18175	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LDN75_RS18185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LDN75_RS18215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LDN75_RS18220	COG0738	Major facilitator superfamily
LDN75_RS18230	COG2030	dehydratase
LDN75_RS18260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDN75_RS18270	COG4989	oxidoreductase activity
LDN75_RS18275	COG0366	Alpha amylase catalytic
LDN75_RS18280	COG0395	ABC-type sugar transport system, permease component
LDN75_RS18285	COG1175	transmembrane transport
LDN75_RS18295	COG1940	carbohydrate kinase activity
LDN75_RS18350	COG0754	glutathionylspermidine amidase activity
LDN75_RS18360	COG5650	phosphatidylinositol metabolic process
LDN75_RS18385	COG5650	phosphatidylinositol metabolic process
LDN75_RS18405	COG0318	PFAM AMP-dependent synthetase and ligase
LDN75_RS18415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDN75_RS18430	COG1309	transcriptional regulator
LDN75_RS18435	COG1131	(ABC) transporter
LDN75_RS18455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LDN75_RS18470	COG1666	GTP binding
LDN75_RS18475	COG0672	)-iron permease
LDN75_RS18485	COG2837	iron assimilation
LDN75_RS18490	COG0501	Belongs to the peptidase M48B family
LDN75_RS18520	COG0531	amino acid
LDN75_RS18565	COG1012	belongs to the aldehyde dehydrogenase family
LDN75_RS18570	COG3835	regulator
LDN75_RS18575	COG2807	transmembrane transport
LDN75_RS18580	COG2186	Transcriptional regulator
LDN75_RS18585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDN75_RS18585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LDN75_RS18595	COG1648	precorrin-2 dehydrogenase activity
LDN75_RS18595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LDN75_RS18600	COG2066	Belongs to the glutaminase family
LDN75_RS18620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDN75_RS18635	COG1116	anion transmembrane transporter activity
LDN75_RS18645	COG2040	homocysteine
LDN75_RS18665	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LDN75_RS18675	COG2860	membrane
LDN75_RS18690	COG0142	geranyltranstransferase activity
LDN75_RS18700	COG2226	methyltransferase
LDN75_RS18705	COG1169	isochorismate synthase
LDN75_RS18715	COG0765	amino acid transport
LDN75_RS18730	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LDN75_RS18740	COG4948	Mandelate Racemase Muconate Lactonizing
LDN75_RS18760	COG1609	Transcriptional regulator
LDN75_RS18770	COG0395	ABC-type sugar transport system, permease component
LDN75_RS18775	COG1175	transmembrane transport
LDN75_RS18785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LDN75_RS18800	COG0390	transport system, permease component
LDN75_RS18805	COG5002	protein histidine kinase activity
LDN75_RS18810	COG0745	RESPONSE REGULATOR receiver
LDN75_RS18815	COG0671	phosphoesterase, PA-phosphatase related
LDN75_RS18875	COG1404	Belongs to the peptidase S8 family
LDN75_RS18890	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDN75_RS18895	COG0022	dehydrogenase e1 component
LDN75_RS18915	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LDN75_RS18945	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LDN75_RS18955	COG1134	teichoic acid transport
LDN75_RS18960	COG1682	transport, permease protein
LDN75_RS18965	COG0438	transferase activity, transferring glycosyl groups
LDN75_RS18985	COG1316	TRANSCRIPTIONal
LDN75_RS19030	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LDN75_RS19035	COG1088	dTDP-glucose 4,6-dehydratase activity
LDN75_RS19045	COG0489	protein tyrosine kinase activity
LDN75_RS19050	COG0110	maltose O-acetyltransferase activity
LDN75_RS19105	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LDN75_RS19125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LDN75_RS19155	COG2828	Protein conserved in bacteria
LDN75_RS19160	COG0583	DNA-binding transcription factor activity
LDN75_RS19165	COG0671	phosphoesterase, PA-phosphatase related
LDN75_RS19175	COG5002	protein histidine kinase activity
LDN75_RS19180	COG0745	RESPONSE REGULATOR receiver
LDN75_RS19205	COG2894	cell division
LDN75_RS19235	COG5002	protein histidine kinase activity
LDN75_RS19245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDN75_RS19250	COG0765	amino acid transport
LDN75_RS19275	COG0667	Aldo Keto reductase
LDN75_RS19280	COG1609	Transcriptional regulator
LDN75_RS19290	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LDN75_RS19295	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
LDN75_RS19315	COG3842	ATPase activity
LDN75_RS19325	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LDN75_RS19330	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LDN75_RS19335	COG1024	Enoyl-CoA hydratase
LDN75_RS19340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDN75_RS19345	COG2151	metal-sulfur cluster biosynthetic enzyme
LDN75_RS19350	COG3396	Phenylacetate-CoA oxygenase
LDN75_RS19355	COG3460	Phenylacetate-CoA oxygenase
LDN75_RS19360	COG3396	Phenylacetate-CoA oxygenase
LDN75_RS19365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDN75_RS19370	COG1388	LysM domain
LDN75_RS19370	COG3942	CHAP domain
LDN75_RS19390	COG3706	GGDEF domain
LDN75_RS19390	COG2203	Gaf domain
LDN75_RS19390	COG5001	Diguanylate cyclase
LDN75_RS19390	COG4251	negative regulation of phosphorylation
LDN75_RS19410	COG2226	methyltransferase
LDN75_RS19420	COG5002	protein histidine kinase activity
LDN75_RS19445	COG2050	protein possibly involved in aromatic compounds catabolism
LDN75_RS19465	COG0477	Major facilitator Superfamily
LDN75_RS19470	COG3119	arylsulfatase activity
LDN75_RS19470	COG3408	Glycogen debranching enzyme
LDN75_RS19480	COG1609	Transcriptional regulator
LDN75_RS19485	COG1012	belongs to the aldehyde dehydrogenase family
LDN75_RS19485	COG2030	dehydratase
LDN75_RS19495	COG1609	Transcriptional regulator
LDN75_RS19510	COG0395	ABC-type sugar transport system, permease component
LDN75_RS19520	COG0673	inositol 2-dehydrogenase activity
LDN75_RS19540	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDN75_RS19545	COG1024	Enoyl-CoA hydratase
LDN75_RS19550	COG0183	Belongs to the thiolase family
LDN75_RS19580	COG2186	Transcriptional regulator
LDN75_RS19585	COG1850	ribulose-bisphosphate carboxylase activity
LDN75_RS19595	COG1063	alcohol dehydrogenase
LDN75_RS19625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LDN75_RS19635	COG0488	(ABC) transporter
LDN75_RS19640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LDN75_RS19645	COG1121	(ABC) transporter
LDN75_RS19650	COG0803	Belongs to the bacterial solute-binding protein 9 family
LDN75_RS19655	COG1266	CAAX protease self-immunity
LDN75_RS19660	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LDN75_RS19690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LDN75_RS19700	COG0785	Cytochrome C biogenesis protein
LDN75_RS19710	COG0406	alpha-ribazole phosphatase activity
LDN75_RS19730	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LDN75_RS19745	COG3328	transposase activity
LDN75_RS19765	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LDN75_RS19770	COG3458	cephalosporin-C deacetylase activity
LDN75_RS19780	COG2755	lipolytic protein G-D-S-L family
LDN75_RS19785	COG0395	ABC-type sugar transport system, permease component
LDN75_RS19790	COG4209	transmembrane transport
LDN75_RS19795	COG1653	transport
LDN75_RS19805	COG5578	integral membrane protein
LDN75_RS19815	COG1953	Uracil, thiamine, allantoin
LDN75_RS19825	COG2814	Major facilitator Superfamily
LDN75_RS19835	COG0395	ABC-type sugar transport system, permease component
LDN75_RS19840	COG1175	transmembrane transport
LDN75_RS19860	COG0395	ABC-type sugar transport system, permease component
LDN75_RS19865	COG1175	transmembrane transport
LDN75_RS19890	COG4948	Mandelate Racemase Muconate Lactonizing
LDN75_RS19895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDN75_RS19905	COG0673	inositol 2-dehydrogenase activity
LDN75_RS19910	COG1609	Transcriptional regulator
LDN75_RS19915	COG2186	Transcriptional regulator
LDN75_RS19925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LDN75_RS19930	COG0640	Transcriptional regulator
LDN75_RS19940	COG0123	including yeast histone deacetylase and acetoin utilization protein
LDN75_RS19950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LDN75_RS19955	COG0569	domain protein
LDN75_RS19960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LDN75_RS19965	COG1082	Xylose isomerase domain protein TIM barrel
LDN75_RS19970	COG0248	Ppx GppA phosphatase
LDN75_RS19980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LDN75_RS19980	COG1754	DNA topoisomerase type I activity
LDN75_RS19990	COG2890	protein-(glutamine-N5) methyltransferase activity
LDN75_RS20005	COG1054	Belongs to the UPF0176 family
LDN75_RS20015	COG1111	helicase
LDN75_RS20015	COG1205	dead DEAH box helicase
LDN75_RS20085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDN75_RS20090	COG1349	DNA-binding transcription factor activity
LDN75_RS20095	COG0577	efflux transmembrane transporter activity
LDN75_RS20095	COG1136	(ABC) transporter
LDN75_RS20105	COG1609	Transcriptional regulator
LDN75_RS20115	COG1175	transmembrane transport
LDN75_RS20120	COG0395	ABC-type sugar transport system, permease component
LDN75_RS20165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LDN75_RS20170	COG1408	metallophosphoesterase
LDN75_RS20175	COG1132	(ABC) transporter
LDN75_RS20180	COG1132	(ABC) transporter
LDN75_RS20200	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LDN75_RS20205	COG0151	Belongs to the GarS family
LDN75_RS20220	COG1301	dicarboxylic acid transport
LDN75_RS20225	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS20235	COG1953	Uracil, thiamine, allantoin
LDN75_RS20240	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LDN75_RS20255	COG0454	-acetyltransferase
LDN75_RS20260	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LDN75_RS20265	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LDN75_RS20270	COG3608	succinylglutamate desuccinylase aspartoacylase
LDN75_RS20270	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LDN75_RS20275	COG2252	PERMEase
LDN75_RS20280	COG0590	tRNA wobble adenosine to inosine editing
LDN75_RS20305	COG2233	PERMEase
LDN75_RS20310	COG1414	Transcriptional regulator
LDN75_RS20320	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LDN75_RS20330	COG3257	ureidoglycine aminohydrolase activity
LDN75_RS20340	COG4585	Histidine kinase
LDN75_RS20345	COG4499	WXG100 protein secretion system (Wss), protein YukC
LDN75_RS20345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LDN75_RS20375	COG0659	secondary active sulfate transmembrane transporter activity
LDN75_RS20380	COG0563	adenylate kinase activity
LDN75_RS20405	COG0477	Major facilitator Superfamily
LDN75_RS20415	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LDN75_RS20425	COG3401	FG-GAP repeat protein
LDN75_RS20465	COG2217	Heavy metal translocating P-type atpase
LDN75_RS20475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LDN75_RS20505	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LDN75_RS20520	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
LDN75_RS20545	COG2267	carboxylic ester hydrolase activity
LDN75_RS20605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDN75_RS20610	COG1024	Enoyl-CoA hydratase
LDN75_RS20615	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LDN75_RS20620	COG0583	DNA-binding transcription factor activity
LDN75_RS20630	COG1301	dicarboxylic acid transport
LDN75_RS20640	COG0405	Gamma-glutamyltransferase
LDN75_RS20700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LDN75_RS20720	COG0477	Major facilitator Superfamily
LDN75_RS20725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDN75_RS20735	COG0583	DNA-binding transcription factor activity
LDN75_RS20745	COG0673	inositol 2-dehydrogenase activity
LDN75_RS20755	COG0673	inositol 2-dehydrogenase activity
LDN75_RS20770	COG1653	transport
LDN75_RS20775	COG1609	Transcriptional regulator
LDN75_RS20795	COG3622	Belongs to the hyi family
LDN75_RS20800	COG2084	Dehydrogenase
LDN75_RS20805	COG3960	tartronate-semialdehyde synthase activity
LDN75_RS20810	COG1929	Belongs to the glycerate kinase type-1 family
LDN75_RS20815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LDN75_RS20820	COG0745	RESPONSE REGULATOR receiver
LDN75_RS20830	COG0745	RESPONSE REGULATOR receiver
LDN75_RS20835	COG1215	transferase activity, transferring glycosyl groups
LDN75_RS20840	COG1366	Belongs to the anti-sigma-factor antagonist family
LDN75_RS20850	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LDN75_RS20855	COG0671	phosphoesterase, PA-phosphatase related
LDN75_RS20880	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LDN75_RS20915	COG0542	response to heat
LDN75_RS20935	COG3585	molybdate ion transport
LDN75_RS20950	COG3304	Inner membrane component domain
LDN75_RS20960	COG0135	phosphoribosylanthranilate isomerase activity
LDN75_RS20975	COG2076	Multidrug Resistance protein
LDN75_RS20980	COG0667	Aldo Keto reductase
LDN75_RS21020	COG1473	amidohydrolase
LDN75_RS21025	COG0477	Major facilitator Superfamily
LDN75_RS21030	COG2807	transmembrane transport
LDN75_RS21040	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LDN75_RS21080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LDN75_RS21125	COG0789	Transcriptional regulator
LDN75_RS21130	COG0484	heat shock protein binding
LDN75_RS21135	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LDN75_RS21140	COG0443	Heat shock 70 kDa protein
LDN75_RS21150	COG3739	integral membrane protein
LDN75_RS21240	COG0436	Aminotransferase
LDN75_RS21260	COG0531	amino acid
LDN75_RS21275	COG3226	Transcriptional regulator
LDN75_RS21280	COG1280	lysine exporter protein (LysE YggA)
LDN75_RS21285	COG1012	belongs to the aldehyde dehydrogenase family
LDN75_RS21300	COG0492	ferredoxin-NADP+ reductase activity
LDN75_RS21305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDN75_RS21330	COG0574	Belongs to the PEP-utilizing enzyme family
LDN75_RS21330	COG3848	Pyruvate phosphate dikinase
LDN75_RS21335	COG2409	Drug exporters of the RND superfamily
LDN75_RS21345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LDN75_RS21350	COG3795	YCII-related domain
LDN75_RS21355	COG4941	Belongs to the sigma-70 factor family
LDN75_RS21360	COG0667	Aldo Keto reductase
LDN75_RS21370	COG1280	lysine exporter protein (LysE YggA)
LDN75_RS21375	COG1609	Transcriptional regulator
LDN75_RS21380	COG1957	nucleoside hydrolase
LDN75_RS21385	COG0477	Major facilitator Superfamily
LDN75_RS21390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDN75_RS21400	COG1309	transcriptional regulator
LDN75_RS21405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDN75_RS21415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LDN75_RS21425	COG0833	amino acid
LDN75_RS21430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LDN75_RS21435	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LDN75_RS21455	COG2986	histidine ammonia-lyase
LDN75_RS21485	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LDN75_RS21490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LDN75_RS21500	COG1122	ATPase activity
LDN75_RS21505	COG4721	ABC-type cobalt transport system, permease component
LDN75_RS21520	COG1320	monovalent cation:proton antiporter activity
LDN75_RS21525	COG2212	antiporter activity
LDN75_RS21530	COG1863	multisubunit Na H antiporter MnhE subunit
LDN75_RS21535	COG0651	ATP synthesis coupled electron transport
LDN75_RS21540	COG1006	Multisubunit Na H antiporter MnhC subunit
LDN75_RS21545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LDN75_RS21545	COG2111	Na H antiporter
LDN75_RS21560	COG0475	glutathione-regulated potassium exporter activity
LDN75_RS21565	COG0717	Belongs to the dCTP deaminase family
LDN75_RS21605	COG0583	DNA-binding transcription factor activity
LDN75_RS21615	COG4974	Belongs to the 'phage' integrase family
LDN75_RS21620	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LDN75_RS21650	COG1609	Transcriptional regulator
LDN75_RS21655	COG0673	inositol 2-dehydrogenase activity
LDN75_RS21680	COG1295	ribonuclease BN
LDN75_RS21690	COG2115	Belongs to the xylose isomerase family
LDN75_RS21695	COG1070	Carbohydrate kinase
LDN75_RS21700	COG1609	Transcriptional regulator
LDN75_RS21715	COG2160	L-arabinose isomerase activity
LDN75_RS21720	COG2017	converts alpha-aldose to the beta-anomer
LDN75_RS21725	COG1609	Transcriptional regulator
LDN75_RS21740	COG3347	Dehydrogenase
LDN75_RS21740	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS21745	COG1070	Carbohydrate kinase
LDN75_RS21750	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LDN75_RS21760	COG3387	PFAM Glycoside hydrolase 15-related
LDN75_RS21765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDN75_RS21775	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LDN75_RS21805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDN75_RS21820	COG1126	abc transporter atp-binding protein
LDN75_RS21825	COG0765	amino acid transport
LDN75_RS21840	COG0433	COG0433 Predicted ATPase
LDN75_RS21865	COG0776	regulation of translation
LDN75_RS21915	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LDN75_RS21920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LDN75_RS21925	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LDN75_RS21930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDN75_RS21930	COG1017	nitric oxide dioxygenase activity
LDN75_RS21970	COG1120	ATPase activity
LDN75_RS21975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDN75_RS21980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDN75_RS22020	COG3012	SEC-C Motif Domain Protein
LDN75_RS22035	COG0667	Aldo Keto reductase
LDN75_RS22060	COG2409	Drug exporters of the RND superfamily
LDN75_RS22100	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
LDN75_RS22105	COG2186	Transcriptional regulator
LDN75_RS22115	COG1027	Aspartate ammonia-lyase
LDN75_RS22130	COG3618	amidohydrolase
LDN75_RS22140	COG3254	rhamnose metabolic process
LDN75_RS22150	COG4948	Mandelate Racemase Muconate Lactonizing
LDN75_RS22160	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS22195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDN75_RS22220	COG4221	oxidoreductase activity
LDN75_RS22230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LDN75_RS22235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LDN75_RS22250	COG1280	lysine exporter protein (LysE YggA)
LDN75_RS22260	COG0640	Transcriptional regulator
LDN75_RS22275	COG1414	Transcriptional regulator
LDN75_RS22285	COG0477	Major facilitator Superfamily
LDN75_RS22295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LDN75_RS22320	COG1760	l-serine dehydratase
LDN75_RS22340	COG0726	polysaccharide deacetylase
LDN75_RS22350	COG0281	malic enzyme
LDN75_RS22355	COG1309	transcriptional regulator
LDN75_RS22385	COG2211	Major facilitator Superfamily
LDN75_RS22395	COG0477	Major facilitator Superfamily
LDN75_RS22400	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LDN75_RS22410	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LDN75_RS22420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDN75_RS22425	COG0477	Major facilitator Superfamily
LDN75_RS22430	COG2814	Major facilitator Superfamily
LDN75_RS22465	COG1113	amino acid transport
LDN75_RS22470	COG0246	Mannitol dehydrogenase
LDN75_RS22475	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDN75_RS22475	COG2213	PTS system mannitol-specific
LDN75_RS22485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LDN75_RS22490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDN75_RS22495	COG1737	Transcriptional regulator
LDN75_RS22500	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LDN75_RS22510	COG0477	Major facilitator Superfamily
LDN75_RS22515	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LDN75_RS22530	COG4608	Belongs to the ABC transporter superfamily
LDN75_RS22535	COG0444	Belongs to the ABC transporter superfamily
LDN75_RS22540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDN75_RS22545	COG0601	transmembrane transport
LDN75_RS22570	COG2267	carboxylic ester hydrolase activity
LDN75_RS22580	COG1793	dna ligase
LDN75_RS22600	COG0686	Belongs to the AlaDH PNT family
LDN75_RS22605	COG3415	Transposase
LDN75_RS22605	COG2801	Transposase and inactivated derivatives
LDN75_RS22635	COG0673	inositol 2-dehydrogenase activity
LDN75_RS22660	COG1309	transcriptional regulator
LDN75_RS22665	COG0431	NADPH-dependent FMN reductase
LDN75_RS22690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDN75_RS22710	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDN75_RS22715	COG0022	dehydrogenase e1 component
LDN75_RS22725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LDN75_RS22730	COG1950	PFAM Membrane protein of
LDN75_RS22745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LDN75_RS22760	COG1607	acyl-coa hydrolase
LDN75_RS22765	COG4221	oxidoreductase activity
LDN75_RS22770	COG0477	Major facilitator Superfamily
LDN75_RS22775	COG1984	allophanate hydrolase subunit 2
LDN75_RS22780	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LDN75_RS22785	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LDN75_RS22790	COG0583	DNA-binding transcription factor activity
LDN75_RS22800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LDN75_RS22805	COG0436	Aminotransferase
LDN75_RS22825	COG3971	2-oxopent-4-enoate hydratase activity
LDN75_RS22840	COG1802	Transcriptional regulator
LDN75_RS22845	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDN75_RS22865	COG2261	transglycosylase associated protein
LDN75_RS22880	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS22905	COG1653	transport
LDN75_RS22915	COG0395	ABC-type sugar transport system, permease component
LDN75_RS22940	COG0515	serine threonine protein kinase
LDN75_RS22975	COG0604	alcohol dehydrogenase
LDN75_RS22985	COG3387	PFAM Glycoside hydrolase 15-related
LDN75_RS23030	COG2814	Major facilitator Superfamily
LDN75_RS23050	COG0243	molybdopterin cofactor binding
LDN75_RS23105	COG1414	Transcriptional regulator
LDN75_RS23130	COG0515	serine threonine protein kinase
LDN75_RS23135	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LDN75_RS23140	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LDN75_RS23145	COG1760	l-serine dehydratase
LDN75_RS23150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LDN75_RS23155	COG0509	glycine decarboxylation via glycine cleavage system
LDN75_RS23160	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LDN75_RS23165	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LDN75_RS23165	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LDN75_RS23180	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LDN75_RS23195	COG1970	mechanosensitive ion channel activity
LDN75_RS23205	COG2271	Major facilitator Superfamily
LDN75_RS23210	COG1802	Transcriptional regulator
LDN75_RS23265	COG1802	Transcriptional regulator
LDN75_RS23270	COG4948	Mandelate Racemase Muconate Lactonizing
LDN75_RS23280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDN75_RS23285	COG0473	3-isopropylmalate dehydrogenase activity
LDN75_RS23295	COG0546	phosphoglycolate phosphatase activity
LDN75_RS23320	COG2814	Major facilitator Superfamily
LDN75_RS23345	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDN75_RS23350	COG0251	oxidation-reduction process
LDN75_RS23360	COG1414	Transcriptional regulator
LDN75_RS23365	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LDN75_RS23375	COG0183	Belongs to the thiolase family
LDN75_RS23380	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LDN75_RS23400	COG3485	protocatechuate 3,4-dioxygenase
LDN75_RS23410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDN75_RS23415	COG1414	Transcriptional regulator
LDN75_RS23435	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LDN75_RS23455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LDN75_RS23460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDN75_RS23475	COG0251	oxidation-reduction process
LDN75_RS23485	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS23490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDN75_RS23495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDN75_RS23530	COG2610	gluconate transmembrane transporter activity
LDN75_RS23540	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LDN75_RS23555	COG1414	Transcriptional regulator
LDN75_RS23590	COG0477	Major facilitator Superfamily
LDN75_RS23630	COG1937	Protein conserved in bacteria
LDN75_RS23655	COG0697	spore germination
LDN75_RS23685	COG2259	Doxx family
LDN75_RS23695	COG1607	acyl-coa hydrolase
LDN75_RS23705	COG3958	Transketolase
LDN75_RS23710	COG3959	Transketolase, thiamine diphosphate binding domain
LDN75_RS23725	COG1028	Short-chain dehydrogenase reductase Sdr
LDN75_RS23730	COG2376	Dihydroxyacetone kinase
LDN75_RS23735	COG0698	ribose 5-phosphate isomerase
LDN75_RS23755	COG0305	Participates in initiation and elongation during chromosome replication
LDN75_RS23795	COG2610	gluconate transmembrane transporter activity
LDN75_RS23800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDN75_RS23805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LDN75_RS23835	COG1414	Transcriptional regulator
LDN75_RS23850	COG0359	binds to the 23S rRNA
LDN75_RS23855	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LDN75_RS23865	COG0360	Binds together with S18 to 16S ribosomal RNA
LDN75_RS23870	COG2801	Transposase and inactivated derivatives
LDN75_RS23870	COG3415	Transposase
LDN75_RS23890	COG1113	amino acid transport
LDN75_RS23895	COG1362	aminopeptidase activity
LDN75_RS23915	COG1414	Transcriptional regulator
LDN75_RS23925	COG0833	amino acid
LDN75_RS23930	COG2197	response regulator
LDN75_RS23935	COG4585	Histidine kinase
LDN75_RS23945	COG1131	(ABC) transporter
LDN75_RS23950	COG1597	lipid kinase activity
LDN75_RS23960	COG0738	Major facilitator superfamily
LDN75_RS23970	COG0488	(ABC) transporter
LDN75_RS23980	COG0768	penicillin binding
LDN75_RS23985	COG1501	Belongs to the glycosyl hydrolase 31 family
LDN75_RS23990	COG2197	response regulator
LDN75_RS23995	COG4585	Histidine kinase
LDN75_RS24005	COG1136	(ABC) transporter
LDN75_RS24010	COG1733	regulation of RNA biosynthetic process
LDN75_RS24015	COG2910	NAD(P)H-binding
LDN75_RS24035	COG0406	alpha-ribazole phosphatase activity
LDN75_RS24040	COG0617	tRNA 3'-terminal CCA addition
LDN75_RS24060	COG0492	ferredoxin-NADP+ reductase activity
LDN75_RS24065	COG3118	belongs to the thioredoxin family
LDN75_RS24080	COG1192	Involved in chromosome partitioning
LDN75_RS24085	COG0357	Ribosomal RNA small subunit methyltransferase G
LDN75_RS24095	COG0706	membrane insertase activity
LDN75_RS24100	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LDN75_RS24105	COG0594	ribonuclease P activity
LDN75_RS24110	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LDN75_RS24180	COG1012	belongs to the aldehyde dehydrogenase family
LDN75_RS24190	COG1012	belongs to the aldehyde dehydrogenase family