locus-tag	class	description
ASPU41_RS00035	COG1126	abc transporter atp-binding protein
ASPU41_RS00040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASPU41_RS00045	COG0765	amino acid transport
ASPU41_RS00050	COG0765	amino acid transport
ASPU41_RS00055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ASPU41_RS00060	COG2171	N-acyltransferase activity
ASPU41_RS00075	COG3226	Transcriptional regulator
ASPU41_RS00110	COG1217	gtp-binding protein TYPA
ASPU41_RS00125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASPU41_RS00130	COG0601	transmembrane transport
ASPU41_RS00140	COG4172	Belongs to the ABC transporter superfamily
ASPU41_RS00160	COG4166	transmembrane transport
ASPU41_RS00165	COG0012	GTP binding
ASPU41_RS00170	COG1322	Protein conserved in bacteria
ASPU41_RS00175	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ASPU41_RS00185	COG1570	exodeoxyribonuclease VII activity
ASPU41_RS00190	COG1722	exodeoxyribonuclease VII activity
ASPU41_RS00195	COG2326	polyphosphate kinase activity
ASPU41_RS00210	COG1174	glycine betaine transport
ASPU41_RS00215	COG1174	glycine betaine transport
ASPU41_RS00225	COG1162	GTPase activity
ASPU41_RS00235	COG2971	BadF BadG BcrA BcrD
ASPU41_RS00245	COG0583	DNA-binding transcription factor activity
ASPU41_RS00250	COG2814	Major facilitator Superfamily
ASPU41_RS00255	COG0626	cystathionine gamma-synthase activity
ASPU41_RS00275	COG0598	Magnesium transport protein CorA
ASPU41_RS00280	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ASPU41_RS00290	COG0488	(ABC) transporter
ASPU41_RS00295	COG2890	protein-(glutamine-N5) methyltransferase activity
ASPU41_RS00310	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ASPU41_RS00315	COG1695	Transcriptional regulator
ASPU41_RS00340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ASPU41_RS00345	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ASPU41_RS00365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ASPU41_RS00365	COG0519	Catalyzes the synthesis of GMP from XMP
ASPU41_RS00385	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ASPU41_RS00390	COG0516	GMP reductase activity
ASPU41_RS00430	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ASPU41_RS00430	COG2755	lipolytic protein G-D-S-L family
ASPU41_RS00445	COG0459	protein refolding
ASPU41_RS00450	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ASPU41_RS00465	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ASPU41_RS00470	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ASPU41_RS00475	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ASPU41_RS00490	COG0802	atpase or kinase
ASPU41_RS00495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ASPU41_RS00515	COG0438	transferase activity, transferring glycosyl groups
ASPU41_RS00520	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ASPU41_RS00535	COG0667	Aldo Keto reductase
ASPU41_RS00560	COG0736	holo-[acyl-carrier-protein] synthase activity
ASPU41_RS00565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ASPU41_RS00570	COG1072	(Pantothenic acid kinase))
ASPU41_RS00575	COG1876	peptidase activity
ASPU41_RS00580	COG1970	mechanosensitive ion channel activity
ASPU41_RS00595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASPU41_RS00600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ASPU41_RS00605	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ASPU41_RS00630	COG0455	bacterial-type flagellum organization
ASPU41_RS00670	COG1192	Involved in chromosome partitioning
ASPU41_RS00700	COG5002	protein histidine kinase activity
ASPU41_RS00705	COG0101	tRNA pseudouridine synthase activity
ASPU41_RS00710	COG0203	ribosomal protein L17
ASPU41_RS00715	COG0202	RNA polymerase activity
ASPU41_RS00720	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ASPU41_RS00725	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ASPU41_RS00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ASPU41_RS00735	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ASPU41_RS00740	COG3191	aminopeptidase activity
ASPU41_RS00745	COG1175	transmembrane transport
ASPU41_RS00755	COG1653	transport
ASPU41_RS00765	COG0563	adenylate kinase activity
ASPU41_RS00775	COG0200	Binds to the 23S rRNA
ASPU41_RS00780	COG1841	ribosomal large subunit assembly
ASPU41_RS00785	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ASPU41_RS00795	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ASPU41_RS00800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ASPU41_RS00805	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ASPU41_RS00810	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ASPU41_RS00815	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ASPU41_RS00820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ASPU41_RS00825	COG0255	Belongs to the universal ribosomal protein uL29 family
ASPU41_RS00830	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ASPU41_RS00835	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ASPU41_RS00840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ASPU41_RS00845	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ASPU41_RS00850	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ASPU41_RS00855	COG0089	rRNA binding
ASPU41_RS00860	COG0088	Forms part of the polypeptide exit tunnel
ASPU41_RS00865	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ASPU41_RS00870	COG0051	transcription antitermination factor activity, RNA binding
ASPU41_RS00885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASPU41_RS00890	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASPU41_RS00895	COG0049	tRNA binding
ASPU41_RS00900	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ASPU41_RS00905	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ASPU41_RS00910	COG0085	RNA polymerase activity
ASPU41_RS00915	COG0183	Belongs to the thiolase family
ASPU41_RS00920	COG0442	prolyl-tRNA aminoacylation
ASPU41_RS00925	COG0222	ribosome binding
ASPU41_RS00930	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ASPU41_RS00940	COG0081	regulation of translation
ASPU41_RS00945	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ASPU41_RS00955	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ASPU41_RS00965	COG0436	Aminotransferase
ASPU41_RS00970	COG2197	response regulator
ASPU41_RS01025	COG3485	protocatechuate 3,4-dioxygenase
ASPU41_RS01035	COG0745	RESPONSE REGULATOR receiver
ASPU41_RS01040	COG0456	acetyltransferase
ASPU41_RS01045	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ASPU41_RS01055	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ASPU41_RS01060	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ASPU41_RS01095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ASPU41_RS01110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ASPU41_RS01115	COG0738	Major facilitator superfamily
ASPU41_RS01125	COG2030	dehydratase
ASPU41_RS01135	COG0659	secondary active sulfate transmembrane transporter activity
ASPU41_RS01155	COG4989	oxidoreductase activity
ASPU41_RS01160	COG0366	Alpha amylase catalytic
ASPU41_RS01165	COG1940	carbohydrate kinase activity
ASPU41_RS01170	COG0702	epimerase
ASPU41_RS01200	COG1051	belongs to the nudix hydrolase family
ASPU41_RS01235	COG0318	PFAM AMP-dependent synthetase and ligase
ASPU41_RS01245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ASPU41_RS01250	COG1131	(ABC) transporter
ASPU41_RS01270	COG0346	lactoylglutathione lyase activity
ASPU41_RS01335	COG1215	transferase activity, transferring glycosyl groups
ASPU41_RS01340	COG1366	Belongs to the anti-sigma-factor antagonist family
ASPU41_RS01350	COG0745	RESPONSE REGULATOR receiver
ASPU41_RS01355	COG5001	Diguanylate cyclase
ASPU41_RS01355	COG3300	MHYT domain
ASPU41_RS01370	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ASPU41_RS01375	COG3300	MHYT domain
ASPU41_RS01375	COG5001	Diguanylate cyclase
ASPU41_RS01385	COG0542	response to heat
ASPU41_RS01400	COG4974	Belongs to the 'phage' integrase family
ASPU41_RS01415	COG1666	GTP binding
ASPU41_RS01420	COG0501	Belongs to the peptidase M48B family
ASPU41_RS01440	COG1116	anion transmembrane transporter activity
ASPU41_RS01445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ASPU41_RS01455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ASPU41_RS01460	COG0531	amino acid
ASPU41_RS01540	COG2186	Transcriptional regulator
ASPU41_RS01565	COG1648	precorrin-2 dehydrogenase activity
ASPU41_RS01565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASPU41_RS01580	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ASPU41_RS01590	COG1690	Belongs to the RtcB family
ASPU41_RS01615	COG0175	sulfate reduction
ASPU41_RS01630	COG2860	membrane
ASPU41_RS01645	COG0142	geranyltranstransferase activity
ASPU41_RS01650	COG0644	oxidoreductase
ASPU41_RS01655	COG2226	methyltransferase
ASPU41_RS01660	COG1169	isochorismate synthase
ASPU41_RS01665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASPU41_RS01670	COG0765	amino acid transport
ASPU41_RS01690	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ASPU41_RS01695	COG0018	arginyl-trna synthetase
ASPU41_RS01705	COG2132	Multicopper oxidase
ASPU41_RS01715	COG1846	Transcriptional regulator
ASPU41_RS01720	COG4948	Mandelate Racemase Muconate Lactonizing
ASPU41_RS01725	COG3764	Sortase (surface protein transpeptidase)
ASPU41_RS01735	COG1621	beta-fructofuranosidase activity
ASPU41_RS01755	COG0436	Aminotransferase
ASPU41_RS01780	COG0765	amino acid transport
ASPU41_RS01785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASPU41_RS01790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ASPU41_RS01840	COG3328	transposase activity
ASPU41_RS01855	COG2801	Transposase and inactivated derivatives
ASPU41_RS01865	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASPU41_RS01870	COG0022	dehydrogenase e1 component
ASPU41_RS01885	COG2244	polysaccharide biosynthetic process
ASPU41_RS01895	COG2826	transposase and inactivated derivatives, IS30 family
ASPU41_RS01905	COG2826	transposase and inactivated derivatives, IS30 family
ASPU41_RS01925	COG1484	DNA-dependent DNA replication
ASPU41_RS01950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ASPU41_RS01970	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ASPU41_RS01975	COG1024	Enoyl-CoA hydratase
ASPU41_RS01980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ASPU41_RS01985	COG2151	metal-sulfur cluster biosynthetic enzyme
ASPU41_RS01990	COG3396	Phenylacetate-CoA oxygenase
ASPU41_RS01995	COG3460	Phenylacetate-CoA oxygenase
ASPU41_RS02000	COG3396	Phenylacetate-CoA oxygenase
ASPU41_RS02005	COG0681	Belongs to the peptidase S26 family
ASPU41_RS02010	COG0489	protein tyrosine kinase activity
ASPU41_RS02025	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ASPU41_RS02030	COG1316	TRANSCRIPTIONal
ASPU41_RS02040	COG1088	dTDP-glucose 4,6-dehydratase activity
ASPU41_RS02045	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ASPU41_RS02055	COG1940	carbohydrate kinase activity
ASPU41_RS02060	COG0277	FAD linked oxidase domain protein
ASPU41_RS02065	COG2115	Belongs to the xylose isomerase family
ASPU41_RS02070	COG1070	Carbohydrate kinase
ASPU41_RS02075	COG0673	inositol 2-dehydrogenase activity
ASPU41_RS02080	COG0673	inositol 2-dehydrogenase activity
ASPU41_RS02090	COG0395	ABC-type sugar transport system, permease component
ASPU41_RS02105	COG0659	secondary active sulfate transmembrane transporter activity
ASPU41_RS02110	COG0789	Transcriptional regulator
ASPU41_RS02125	COG2217	Heavy metal translocating P-type atpase
ASPU41_RS02135	COG1611	Belongs to the LOG family
ASPU41_RS02140	COG1136	(ABC) transporter
ASPU41_RS02140	COG4591	ABC-type transport system involved in lipoprotein release permease component
ASPU41_RS02145	COG4591	ABC-type transport system involved in lipoprotein release permease component
ASPU41_RS02160	COG2217	Heavy metal translocating P-type atpase
ASPU41_RS02195	COG2132	Multicopper oxidase
ASPU41_RS02250	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ASPU41_RS02260	COG0857	belongs to the CobB CobQ family
ASPU41_RS02260	COG0280	phosphate acetyltransferase
ASPU41_RS02270	COG2050	protein possibly involved in aromatic compounds catabolism
ASPU41_RS02295	COG2030	dehydratase
ASPU41_RS02295	COG1012	belongs to the aldehyde dehydrogenase family
ASPU41_RS02300	COG2050	protein possibly involved in aromatic compounds catabolism
ASPU41_RS02310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ASPU41_RS02310	COG1017	nitric oxide dioxygenase activity
ASPU41_RS02325	COG2755	lipolytic protein G-D-S-L family
ASPU41_RS02335	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASPU41_RS02340	COG1024	Enoyl-CoA hydratase
ASPU41_RS02345	COG0183	Belongs to the thiolase family
ASPU41_RS02360	COG3237	CsbD-like
ASPU41_RS02375	COG0488	(ABC) transporter
ASPU41_RS02380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ASPU41_RS02385	COG1121	(ABC) transporter
ASPU41_RS02395	COG1266	CAAX protease self-immunity
ASPU41_RS02405	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ASPU41_RS02435	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ASPU41_RS02445	COG0785	Cytochrome C biogenesis protein
ASPU41_RS02450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ASPU41_RS02455	COG0406	alpha-ribazole phosphatase activity
ASPU41_RS02460	COG2353	YceI-like domain
ASPU41_RS02475	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ASPU41_RS02495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ASPU41_RS02510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ASPU41_RS02515	COG0640	Transcriptional regulator
ASPU41_RS02525	COG0123	including yeast histone deacetylase and acetoin utilization protein
ASPU41_RS02530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ASPU41_RS02535	COG0569	domain protein
ASPU41_RS02540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ASPU41_RS02540	COG0723	plastoquinol--plastocyanin reductase activity
ASPU41_RS02560	COG3795	YCII-related domain
ASPU41_RS02565	COG0248	Ppx GppA phosphatase
ASPU41_RS02575	COG1754	DNA topoisomerase type I activity
ASPU41_RS02575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ASPU41_RS02585	COG2890	protein-(glutamine-N5) methyltransferase activity
ASPU41_RS02590	COG0789	Transcriptional regulator
ASPU41_RS02610	COG1054	Belongs to the UPF0176 family
ASPU41_RS02620	COG1205	dead DEAH box helicase
ASPU41_RS02620	COG1111	helicase
ASPU41_RS02660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ASPU41_RS02660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ASPU41_RS02670	COG1051	belongs to the nudix hydrolase family
ASPU41_RS02675	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ASPU41_RS02685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASPU41_RS02735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ASPU41_RS02740	COG1408	metallophosphoesterase
ASPU41_RS02745	COG1132	(ABC) transporter
ASPU41_RS02750	COG1132	(ABC) transporter
ASPU41_RS02770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ASPU41_RS02775	COG0151	Belongs to the GarS family
ASPU41_RS02795	COG1028	Short-chain dehydrogenase reductase Sdr
ASPU41_RS02810	COG0546	phosphoglycolate phosphatase activity
ASPU41_RS02820	COG3387	PFAM Glycoside hydrolase 15-related
ASPU41_RS02880	COG4948	Mandelate Racemase Muconate Lactonizing
ASPU41_RS02890	COG0800	Aldolase
ASPU41_RS02895	COG4948	Mandelate Racemase Muconate Lactonizing
ASPU41_RS02905	COG1175	transmembrane transport
ASPU41_RS02920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ASPU41_RS02925	COG0589	response to stress
ASPU41_RS02970	COG2267	carboxylic ester hydrolase activity
ASPU41_RS02990	COG0693	protein deglycase activity
ASPU41_RS03095	COG2244	polysaccharide biosynthetic process
ASPU41_RS03105	COG0318	PFAM AMP-dependent synthetase and ligase
ASPU41_RS03130	COG0463	Glycosyl transferase, family 2
ASPU41_RS03150	COG1028	Short-chain dehydrogenase reductase Sdr
ASPU41_RS03155	COG1309	transcriptional regulator
ASPU41_RS03185	COG0395	ABC-type sugar transport system, permease component
ASPU41_RS03190	COG4209	transmembrane transport
ASPU41_RS03195	COG1609	Transcriptional regulator
ASPU41_RS03200	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ASPU41_RS03210	COG1349	DNA-binding transcription factor activity
ASPU41_RS03215	COG1070	Carbohydrate kinase
ASPU41_RS03230	COG2376	Dihydroxyacetone kinase
ASPU41_RS03245	COG1129	ABC transporter
ASPU41_RS03270	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ASPU41_RS03285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ASPU41_RS03355	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ASPU41_RS03365	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ASPU41_RS03380	COG0596	Alpha beta hydrolase
ASPU41_RS03385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ASPU41_RS03390	COG0579	oxidoreductase
ASPU41_RS03395	COG1960	acyl-CoA dehydrogenase activity
ASPU41_RS03400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ASPU41_RS03405	COG3971	2-oxopent-4-enoate hydratase activity
ASPU41_RS03410	COG1028	Short-chain dehydrogenase reductase Sdr
ASPU41_RS03415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ASPU41_RS03430	COG2358	TRAP transporter, solute receptor (TAXI family
ASPU41_RS03455	COG2807	transmembrane transport
ASPU41_RS03485	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
ASPU41_RS03505	COG3845	ABC transporter
ASPU41_RS03510	COG3415	Transposase
ASPU41_RS03510	COG2801	Transposase and inactivated derivatives
ASPU41_RS03515	COG1410	methionine synthase
ASPU41_RS03515	COG0646	methionine synthase
ASPU41_RS03545	COG1028	Short-chain dehydrogenase reductase Sdr
ASPU41_RS03550	COG1028	Short-chain dehydrogenase reductase Sdr
ASPU41_RS03565	COG0252	asparaginase activity
ASPU41_RS03570	COG1609	Transcriptional regulator
ASPU41_RS03575	COG2508	Transcriptional regulator
ASPU41_RS03590	COG0439	Biotin carboxylase
ASPU41_RS03595	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ASPU41_RS03600	COG1984	allophanate hydrolase subunit 2
ASPU41_RS03615	COG1984	allophanate hydrolase subunit 2
ASPU41_RS03620	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ASPU41_RS03680	COG4948	Mandelate Racemase Muconate Lactonizing
ASPU41_RS03710	COG1028	Short-chain dehydrogenase reductase Sdr
ASPU41_RS03715	COG0747	negative chemotaxis
ASPU41_RS03725	COG4608	Belongs to the ABC transporter superfamily
ASPU41_RS03730	COG0601	transmembrane transport
ASPU41_RS03735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASPU41_RS03745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ASPU41_RS03760	COG0251	oxidation-reduction process
ASPU41_RS03765	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ASPU41_RS03785	COG2801	Transposase and inactivated derivatives
ASPU41_RS03810	COG4974	Belongs to the 'phage' integrase family
ASPU41_RS03830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ASPU41_RS03840	COG2267	carboxylic ester hydrolase activity
ASPU41_RS03880	COG0667	Aldo Keto reductase
ASPU41_RS03885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ASPU41_RS03895	COG0590	tRNA wobble adenosine to inosine editing
ASPU41_RS03910	COG3257	ureidoglycine aminohydrolase activity
ASPU41_RS03915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ASPU41_RS03920	COG3622	Belongs to the hyi family
ASPU41_RS03925	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ASPU41_RS03930	COG2226	methyltransferase
ASPU41_RS03945	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ASPU41_RS03960	COG0542	response to heat
ASPU41_RS03965	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ASPU41_RS03985	COG3585	molybdate ion transport
ASPU41_RS04020	COG2353	YceI-like domain
ASPU41_RS04025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASPU41_RS04030	COG0135	phosphoribosylanthranilate isomerase activity
ASPU41_RS04065	COG0513	Belongs to the DEAD box helicase family
ASPU41_RS04105	COG2807	transmembrane transport
ASPU41_RS04110	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ASPU41_RS04120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ASPU41_RS04150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ASPU41_RS04155	COG0800	Aldolase
ASPU41_RS04170	COG0395	ABC-type sugar transport system, permease component
ASPU41_RS04175	COG1175	transmembrane transport
ASPU41_RS04185	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ASPU41_RS04190	COG1414	Transcriptional regulator
ASPU41_RS04195	COG1921	L-seryl-tRNASec selenium transferase activity
ASPU41_RS04200	COG0251	oxidation-reduction process
ASPU41_RS04220	COG1802	Transcriptional regulator
ASPU41_RS04235	COG3971	2-oxopent-4-enoate hydratase activity
ASPU41_RS04250	COG0789	Transcriptional regulator
ASPU41_RS04255	COG0484	heat shock protein binding
ASPU41_RS04260	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ASPU41_RS04265	COG0443	Heat shock 70 kDa protein
ASPU41_RS04285	COG2409	Drug exporters of the RND superfamily
ASPU41_RS04295	COG3314	Sporulation integral membrane protein YlbJ
ASPU41_RS04310	COG4124	Belongs to the glycosyl hydrolase 26 family
ASPU41_RS04310	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ASPU41_RS04320	COG1280	lysine exporter protein (LysE YggA)
ASPU41_RS04330	COG0477	Major facilitator Superfamily
ASPU41_RS04350	COG1028	Short-chain dehydrogenase reductase Sdr
ASPU41_RS04360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ASPU41_RS04365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ASPU41_RS04370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ASPU41_RS04370	COG0512	Glutamine amidotransferase of anthranilate synthase
ASPU41_RS04400	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ASPU41_RS04405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ASPU41_RS04415	COG1122	ATPase activity
ASPU41_RS04420	COG4721	ABC-type cobalt transport system, permease component
ASPU41_RS04425	COG4702	Belongs to the UPF0303 family
ASPU41_RS04435	COG1320	monovalent cation:proton antiporter activity
ASPU41_RS04440	COG2212	antiporter activity
ASPU41_RS04450	COG0651	ATP synthesis coupled electron transport
ASPU41_RS04460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ASPU41_RS04460	COG2111	Na H antiporter
ASPU41_RS04475	COG0475	glutathione-regulated potassium exporter activity
ASPU41_RS04480	COG0717	Belongs to the dCTP deaminase family
ASPU41_RS04505	COG0583	DNA-binding transcription factor activity
ASPU41_RS04515	COG1012	belongs to the aldehyde dehydrogenase family
ASPU41_RS04520	COG0531	amino acid
ASPU41_RS04530	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ASPU41_RS04550	COG3387	PFAM Glycoside hydrolase 15-related
ASPU41_RS04555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASPU41_RS04575	COG0433	COG0433 Predicted ATPase
ASPU41_RS04595	COG3336	cytochrome c oxidase
ASPU41_RS04600	COG0776	regulation of translation
ASPU41_RS04640	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ASPU41_RS04645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ASPU41_RS04650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ASPU41_RS04655	COG1017	nitric oxide dioxygenase activity
ASPU41_RS04655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ASPU41_RS04675	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ASPU41_RS04675	COG2066	Belongs to the glutaminase family
ASPU41_RS04700	COG1120	ATPase activity
ASPU41_RS04705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASPU41_RS04710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASPU41_RS04750	COG3012	SEC-C Motif Domain Protein
ASPU41_RS04760	COG0667	Aldo Keto reductase
ASPU41_RS04765	COG0702	epimerase
ASPU41_RS04775	COG0698	ribose 5-phosphate isomerase
ASPU41_RS04785	COG1028	Short-chain dehydrogenase reductase Sdr
ASPU41_RS04800	COG3959	Transketolase, thiamine diphosphate binding domain
ASPU41_RS04805	COG3958	Transketolase
ASPU41_RS04825	COG1595	DNA-templated transcription, initiation
ASPU41_RS04860	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ASPU41_RS04870	COG1472	Belongs to the glycosyl hydrolase 3 family
ASPU41_RS04885	COG0039	L-malate dehydrogenase activity
ASPU41_RS04895	COG0640	Transcriptional regulator
ASPU41_RS04925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASPU41_RS04935	COG1522	sequence-specific DNA binding
ASPU41_RS04940	COG1280	lysine exporter protein (LysE YggA)
ASPU41_RS04965	COG1309	transcriptional regulator
ASPU41_RS04980	COG0477	Major facilitator Superfamily
ASPU41_RS04990	COG0246	Mannitol dehydrogenase
ASPU41_RS04995	COG2213	PTS system mannitol-specific
ASPU41_RS04995	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASPU41_RS05005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ASPU41_RS05025	COG0686	Belongs to the AlaDH PNT family
ASPU41_RS05030	COG0673	inositol 2-dehydrogenase activity
ASPU41_RS05035	COG1309	transcriptional regulator
ASPU41_RS05040	COG0431	NADPH-dependent FMN reductase
ASPU41_RS05045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASPU41_RS05050	COG0589	response to stress
ASPU41_RS05080	COG0318	PFAM AMP-dependent synthetase and ligase
ASPU41_RS05095	COG3485	protocatechuate 3,4-dioxygenase
ASPU41_RS05100	COG4829	muconolactone delta-isomerase
ASPU41_RS05110	COG0583	DNA-binding transcription factor activity
ASPU41_RS05115	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASPU41_RS05120	COG0022	dehydrogenase e1 component
ASPU41_RS05130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ASPU41_RS05135	COG1950	PFAM Membrane protein of
ASPU41_RS05150	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ASPU41_RS05165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ASPU41_RS05170	COG1607	acyl-coa hydrolase
ASPU41_RS05175	COG1840	ABC-type Fe3 transport system, periplasmic component
ASPU41_RS05180	COG3842	ATPase activity
ASPU41_RS05185	COG1178	ABC-type Fe3 transport system permease component
ASPU41_RS05195	COG1414	Transcriptional regulator
ASPU41_RS05200	COG1970	mechanosensitive ion channel activity
ASPU41_RS05230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ASPU41_RS05235	COG2244	polysaccharide biosynthetic process
ASPU41_RS05240	COG1216	Glycosyl transferase, family 2
ASPU41_RS05250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ASPU41_RS05255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ASPU41_RS05260	COG0673	inositol 2-dehydrogenase activity
ASPU41_RS05265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ASPU41_RS05270	COG1597	lipid kinase activity
ASPU41_RS05280	COG1414	Transcriptional regulator
ASPU41_RS05285	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ASPU41_RS05295	COG0183	Belongs to the thiolase family
ASPU41_RS05300	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ASPU41_RS05310	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ASPU41_RS05315	COG3485	protocatechuate 3,4-dioxygenase
ASPU41_RS05320	COG3485	protocatechuate 3,4-dioxygenase
ASPU41_RS05330	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ASPU41_RS05335	COG1414	Transcriptional regulator
ASPU41_RS05340	COG0477	Major facilitator Superfamily
ASPU41_RS05345	COG1793	dna ligase
ASPU41_RS05390	COG1937	Protein conserved in bacteria
ASPU41_RS05415	COG0697	spore germination
ASPU41_RS05435	COG0534	Mate efflux family protein
ASPU41_RS05440	COG2259	Doxx family
ASPU41_RS05445	COG1607	acyl-coa hydrolase
ASPU41_RS05450	COG0305	Participates in initiation and elongation during chromosome replication
ASPU41_RS05485	COG0359	binds to the 23S rRNA
ASPU41_RS05490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ASPU41_RS05500	COG0360	Binds together with S18 to 16S ribosomal RNA
ASPU41_RS05525	COG1362	aminopeptidase activity
ASPU41_RS05535	COG1113	amino acid transport
ASPU41_RS05540	COG2197	response regulator
ASPU41_RS05545	COG4585	Histidine kinase
ASPU41_RS05555	COG1131	(ABC) transporter
ASPU41_RS05570	COG0738	Major facilitator superfamily
ASPU41_RS05580	COG0247	lactate metabolic process
ASPU41_RS05580	COG0277	FAD linked oxidase domain protein
ASPU41_RS05585	COG1620	l-lactate permease
ASPU41_RS05605	COG2197	response regulator
ASPU41_RS05630	COG0406	alpha-ribazole phosphatase activity
ASPU41_RS05635	COG0617	tRNA 3'-terminal CCA addition
ASPU41_RS05655	COG0492	ferredoxin-NADP+ reductase activity
ASPU41_RS05660	COG3118	belongs to the thioredoxin family
ASPU41_RS05670	COG1192	Involved in chromosome partitioning
ASPU41_RS05675	COG0357	Ribosomal RNA small subunit methyltransferase G
ASPU41_RS05685	COG0706	membrane insertase activity
ASPU41_RS05690	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ASPU41_RS05695	COG0594	ribonuclease P activity
ASPU41_RS05700	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ASPU41_RS05705	COG0592	DNA-directed DNA polymerase activity
ASPU41_RS05710	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ASPU41_RS05715	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ASPU41_RS05720	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
ASPU41_RS05725	COG0187	DNA topoisomerase II activity
ASPU41_RS05730	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ASPU41_RS05735	COG3266	domain, Protein
ASPU41_RS05760	COG1215	transferase activity, transferring glycosyl groups
ASPU41_RS05775	COG0705	Rhomboid family
ASPU41_RS05780	COG2818	Glycosylase
ASPU41_RS05795	COG0515	serine threonine protein kinase
ASPU41_RS05800	COG0515	serine threonine protein kinase
ASPU41_RS05805	COG0768	penicillin binding
ASPU41_RS05820	COG1716	ATPase activity
ASPU41_RS05825	COG1716	ATPase activity
ASPU41_RS05860	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ASPU41_RS05870	COG0346	lactoylglutathione lyase activity
ASPU41_RS05900	COG4336	lyase activity
ASPU41_RS05905	COG1914	H( )-stimulated, divalent metal cation uptake system
ASPU41_RS05910	COG2186	Transcriptional regulator
ASPU41_RS05915	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ASPU41_RS05920	COG1984	allophanate hydrolase subunit 2
ASPU41_RS05925	COG4770	biotin carboxylase activity
ASPU41_RS05955	COG2826	transposase and inactivated derivatives, IS30 family
ASPU41_RS06065	COG2197	response regulator
ASPU41_RS06080	COG2801	Transposase and inactivated derivatives
ASPU41_RS06100	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ASPU41_RS06105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ASPU41_RS06110	COG0698	ribose 5-phosphate isomerase
ASPU41_RS06115	COG0191	fructose-bisphosphate aldolase activity
ASPU41_RS06175	COG0647	UMP catabolic process
ASPU41_RS06180	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ASPU41_RS06200	COG2826	transposase and inactivated derivatives, IS30 family
ASPU41_RS06210	COG1064	alcohol dehydrogenase
ASPU41_RS06230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ASPU41_RS06240	COG2186	Transcriptional regulator
ASPU41_RS06245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ASPU41_RS06270	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASPU41_RS06270	COG1024	Enoyl-CoA hydratase
ASPU41_RS06275	COG1960	acyl-CoA dehydrogenase activity
ASPU41_RS06280	COG0318	PFAM AMP-dependent synthetase and ligase
ASPU41_RS06285	COG0183	Belongs to the thiolase family
ASPU41_RS06290	COG1309	transcriptional regulator
ASPU41_RS06295	COG2610	gluconate transmembrane transporter activity
ASPU41_RS06305	COG1028	Short-chain dehydrogenase reductase Sdr
ASPU41_RS06315	COG3848	Pyruvate phosphate dikinase
ASPU41_RS06315	COG0574	Belongs to the PEP-utilizing enzyme family
ASPU41_RS06325	COG2188	Transcriptional regulator
ASPU41_RS06335	COG0477	Major facilitator Superfamily
ASPU41_RS06340	COG1473	amidohydrolase
ASPU41_RS06355	COG1113	amino acid transport
ASPU41_RS06365	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ASPU41_RS06375	COG1414	Transcriptional regulator
ASPU41_RS06385	COG0574	Belongs to the PEP-utilizing enzyme family
ASPU41_RS06385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ASPU41_RS06390	COG0574	Belongs to the PEP-utilizing enzyme family
ASPU41_RS06390	COG3848	Pyruvate phosphate dikinase
ASPU41_RS06445	COG2847	Copper chaperone PCu(A)C
ASPU41_RS06460	COG2188	Transcriptional regulator
ASPU41_RS06470	COG0785	Cytochrome C biogenesis protein
ASPU41_RS06475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ASPU41_RS06475	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ASPU41_RS06490	COG0477	Major facilitator Superfamily
ASPU41_RS06495	COG1609	Transcriptional regulator
ASPU41_RS06500	COG0659	secondary active sulfate transmembrane transporter activity
ASPU41_RS06515	COG0076	glutamate decarboxylase activity
ASPU41_RS06520	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ASPU41_RS06550	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ASPU41_RS06555	COG0569	domain protein
ASPU41_RS06560	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ASPU41_RS06570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASPU41_RS06570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASPU41_RS06585	COG2186	Transcriptional regulator
ASPU41_RS06590	COG2084	Dehydrogenase
ASPU41_RS06600	COG0656	L-ascorbic acid biosynthetic process
ASPU41_RS06605	COG0667	Aldo Keto reductase
ASPU41_RS06615	COG1349	DNA-binding transcription factor activity
ASPU41_RS06630	COG1879	ABC-type sugar transport system periplasmic component
ASPU41_RS06640	COG1172	Belongs to the binding-protein-dependent transport system permease family
ASPU41_RS06650	COG1869	D-ribose catabolic process
ASPU41_RS06685	COG0561	phosphatase activity
ASPU41_RS06695	COG0584	glycerophosphoryl diester phosphodiesterase
ASPU41_RS06700	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ASPU41_RS06700	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ASPU41_RS06710	COG1929	Belongs to the glycerate kinase type-1 family
ASPU41_RS06725	COG1028	Short-chain dehydrogenase reductase Sdr
ASPU41_RS06740	COG2233	PERMEase
ASPU41_RS06745	COG0778	Nitroreductase
ASPU41_RS06750	COG3706	GGDEF domain
ASPU41_RS06775	COG0154	amidase activity
ASPU41_RS06780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASPU41_RS06780	COG0425	Belongs to the sulfur carrier protein TusA family
ASPU41_RS06795	COG1597	lipid kinase activity
ASPU41_RS06800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ASPU41_RS06805	COG0561	phosphatase activity
ASPU41_RS06840	COG2027	D-alanyl-D-alanine carboxypeptidase
ASPU41_RS06850	COG0037	tRNA processing
ASPU41_RS06860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASPU41_RS06865	COG0302	gtp cyclohydrolase
ASPU41_RS06870	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ASPU41_RS06875	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ASPU41_RS06905	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ASPU41_RS06925	COG1435	thymidine kinase activity
ASPU41_RS06930	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ASPU41_RS06950	COG0823	Involved in the tonB-independent uptake of proteins
ASPU41_RS06950	COG1506	peptidase
ASPU41_RS06955	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ASPU41_RS06960	COG2376	Dihydroxyacetone kinase
ASPU41_RS06965	COG1461	Dihydroxyacetone kinase
ASPU41_RS06970	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ASPU41_RS07000	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ASPU41_RS07005	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ASPU41_RS07010	COG0515	serine threonine protein kinase
ASPU41_RS07010	COG2815	serine threonine protein kinase
ASPU41_RS07030	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ASPU41_RS07060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ASPU41_RS07075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ASPU41_RS07080	COG0306	phosphate transporter
ASPU41_RS07105	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ASPU41_RS07135	COG1796	DNA polymerase
ASPU41_RS07135	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ASPU41_RS07145	COG2890	protein-(glutamine-N5) methyltransferase activity
ASPU41_RS07155	COG2261	transglycosylase associated protein
ASPU41_RS07160	COG0667	Aldo Keto reductase
ASPU41_RS07165	COG3360	Dodecin
ASPU41_RS07175	COG1937	Protein conserved in bacteria
ASPU41_RS07195	COG2610	gluconate transmembrane transporter activity
ASPU41_RS07225	COG0477	Major facilitator Superfamily
ASPU41_RS07245	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ASPU41_RS07265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASPU41_RS07265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASPU41_RS07265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASPU41_RS07275	COG1349	DNA-binding transcription factor activity
ASPU41_RS07285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ASPU41_RS07320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ASPU41_RS07330	COG1140	nitrate reductase beta subunit
ASPU41_RS07350	COG2733	membrane
ASPU41_RS07360	COG3559	Exporter of polyketide antibiotics
ASPU41_RS07365	COG1131	(ABC) transporter
ASPU41_RS07410	COG4122	O-methyltransferase activity
ASPU41_RS07440	COG4948	Mandelate Racemase Muconate Lactonizing
ASPU41_RS07445	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ASPU41_RS07450	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ASPU41_RS07450	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ASPU41_RS07455	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ASPU41_RS07465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ASPU41_RS07470	COG0574	Belongs to the PEP-utilizing enzyme family
ASPU41_RS07470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ASPU41_RS07475	COG2217	Heavy metal translocating P-type atpase
ASPU41_RS07485	COG0726	polysaccharide deacetylase
ASPU41_RS07505	COG1295	ribonuclease BN
ASPU41_RS07530	COG0583	DNA-binding transcription factor activity
ASPU41_RS07535	COG1028	Short-chain dehydrogenase reductase Sdr
ASPU41_RS07545	COG0604	alcohol dehydrogenase
ASPU41_RS07560	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ASPU41_RS07575	COG3263	regulation of cellular component size
ASPU41_RS07580	COG0010	Belongs to the arginase family
ASPU41_RS07585	COG2252	PERMEase
ASPU41_RS07605	COG3848	Pyruvate phosphate dikinase
ASPU41_RS07605	COG0574	Belongs to the PEP-utilizing enzyme family
ASPU41_RS07635	COG0697	spore germination
ASPU41_RS07640	COG0583	DNA-binding transcription factor activity
ASPU41_RS07670	COG3328	transposase activity
ASPU41_RS07680	COG4941	Belongs to the sigma-70 factor family
ASPU41_RS07690	COG2176	DNA-directed DNA polymerase activity
ASPU41_RS07730	COG4974	Belongs to the 'phage' integrase family
ASPU41_RS07750	COG2801	Transposase and inactivated derivatives
ASPU41_RS07765	COG3387	PFAM Glycoside hydrolase 15-related
ASPU41_RS07785	COG2226	methyltransferase
ASPU41_RS07795	COG4134	Bacterial extracellular solute-binding protein
ASPU41_RS07810	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ASPU41_RS07820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ASPU41_RS07835	COG0785	Cytochrome C biogenesis protein
ASPU41_RS07845	COG3118	belongs to the thioredoxin family
ASPU41_RS07865	COG3118	belongs to the thioredoxin family
ASPU41_RS07870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASPU41_RS07880	COG0789	Transcriptional regulator
ASPU41_RS07895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ASPU41_RS07985	COG0596	Alpha beta hydrolase
ASPU41_RS08020	COG2182	Extracellular solute-binding protein
ASPU41_RS08040	COG1609	Transcriptional regulator
ASPU41_RS08060	COG1024	Enoyl-CoA hydratase
ASPU41_RS08080	COG0477	Major facilitator Superfamily
ASPU41_RS08095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASPU41_RS08100	COG1960	acyl-CoA dehydrogenase activity
ASPU41_RS08105	COG1278	Cold shock
ASPU41_RS08110	COG1215	transferase activity, transferring glycosyl groups
ASPU41_RS08125	COG3848	Pyruvate phosphate dikinase
ASPU41_RS08125	COG0574	Belongs to the PEP-utilizing enzyme family
ASPU41_RS08135	COG1063	alcohol dehydrogenase
ASPU41_RS08145	COG0145	ligase activity
ASPU41_RS08150	COG4647	ligase activity
ASPU41_RS08155	COG0145	ligase activity
ASPU41_RS08160	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
ASPU41_RS08195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ASPU41_RS08215	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASPU41_RS08220	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASPU41_RS08220	COG0022	dehydrogenase e1 component
ASPU41_RS08225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ASPU41_RS08230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASPU41_RS08235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ASPU41_RS08260	COG0357	Ribosomal RNA small subunit methyltransferase G
ASPU41_RS08260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ASPU41_RS08265	COG0191	fructose-bisphosphate aldolase activity
ASPU41_RS08285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ASPU41_RS08305	COG1832	CoA-binding protein
ASPU41_RS08320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASPU41_RS08325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ASPU41_RS08335	COG1116	anion transmembrane transporter activity
ASPU41_RS08340	COG1832	CoA-binding protein
ASPU41_RS08345	COG2315	Protein conserved in bacteria
ASPU41_RS08350	COG4762	Protein conserved in bacteria
ASPU41_RS08375	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ASPU41_RS08380	COG0047	phosphoribosylformylglycinamidine synthase activity
ASPU41_RS08415	COG1846	Transcriptional regulator
ASPU41_RS08435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ASPU41_RS08465	COG0739	heme binding
ASPU41_RS08465	COG0741	lytic transglycosylase activity
ASPU41_RS08465	COG1196	nuclear chromosome segregation
ASPU41_RS08470	COG0386	Belongs to the glutathione peroxidase family
ASPU41_RS08475	COG1063	alcohol dehydrogenase
ASPU41_RS08480	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ASPU41_RS08485	COG0438	transferase activity, transferring glycosyl groups
ASPU41_RS08510	COG0438	transferase activity, transferring glycosyl groups
ASPU41_RS08530	COG2807	transmembrane transport
ASPU41_RS08535	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ASPU41_RS08545	COG1396	sequence-specific DNA binding
ASPU41_RS08550	COG0028	Belongs to the TPP enzyme family
ASPU41_RS08560	COG0351	phosphomethylpyrimidine kinase
ASPU41_RS08565	COG0477	Major facilitator Superfamily
ASPU41_RS08580	COG1609	Transcriptional regulator
ASPU41_RS08595	COG0343	queuine tRNA-ribosyltransferase activity
ASPU41_RS08625	COG3842	ATPase activity
ASPU41_RS08650	COG1960	acyl-CoA dehydrogenase activity
ASPU41_RS08670	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ASPU41_RS08685	COG0564	pseudouridine synthase activity
ASPU41_RS08710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ASPU41_RS08715	COG1201	RNA secondary structure unwinding
ASPU41_RS08745	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ASPU41_RS08765	COG4974	Belongs to the 'phage' integrase family
ASPU41_RS08770	COG0582	viral genome integration into host DNA
ASPU41_RS08775	COG4974	Belongs to the 'phage' integrase family
ASPU41_RS08820	COG0667	Aldo Keto reductase
ASPU41_RS08835	COG0477	Major facilitator Superfamily
ASPU41_RS08855	COG0438	transferase activity, transferring glycosyl groups
ASPU41_RS08870	COG0671	phosphoesterase, PA-phosphatase related
ASPU41_RS08875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ASPU41_RS08890	COG2205	protein histidine kinase activity
ASPU41_RS08895	COG0745	RESPONSE REGULATOR receiver
ASPU41_RS08910	COG2062	phosphohistidine phosphatase, SixA
ASPU41_RS08930	COG1309	transcriptional regulator
ASPU41_RS08935	COG1511	domain protein
ASPU41_RS08960	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ASPU41_RS08970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ASPU41_RS08970	COG1017	nitric oxide dioxygenase activity
ASPU41_RS08985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASPU41_RS08990	COG0514	ATP-dependent DNA helicase (RecQ)
ASPU41_RS08995	COG0477	Major facilitator Superfamily
ASPU41_RS09010	COG1505	serine-type exopeptidase activity
ASPU41_RS09035	COG1028	Short-chain dehydrogenase reductase Sdr
ASPU41_RS09035	COG3321	synthase
ASPU41_RS09035	COG0604	alcohol dehydrogenase
ASPU41_RS09045	COG1966	Carbon starvation protein
ASPU41_RS09065	COG0656	L-ascorbic acid biosynthetic process
ASPU41_RS09090	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ASPU41_RS09120	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ASPU41_RS09125	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ASPU41_RS09145	COG0588	phosphoglycerate mutase activity
ASPU41_RS09155	COG5002	protein histidine kinase activity
ASPU41_RS09175	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ASPU41_RS09180	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ASPU41_RS09190	COG0215	cysteine-tRNA ligase activity
ASPU41_RS09225	COG0366	Alpha amylase catalytic
ASPU41_RS09235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ASPU41_RS09265	COG0277	FAD linked oxidase domain protein
ASPU41_RS09275	COG3842	ATPase activity
ASPU41_RS09285	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ASPU41_RS09320	COG0783	Belongs to the Dps family
ASPU41_RS09325	COG0477	Major facilitator Superfamily
ASPU41_RS09335	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ASPU41_RS09335	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ASPU41_RS09340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ASPU41_RS09345	COG0509	glycine decarboxylation via glycine cleavage system
ASPU41_RS09350	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ASPU41_RS09360	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ASPU41_RS09380	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ASPU41_RS09395	COG1278	Cold shock
ASPU41_RS09405	COG0459	protein refolding
ASPU41_RS09410	COG0328	RNA-DNA hybrid ribonuclease activity
ASPU41_RS09420	COG2205	protein histidine kinase activity
ASPU41_RS09425	COG0745	RESPONSE REGULATOR receiver
ASPU41_RS09445	COG1278	Cold shock
ASPU41_RS09455	COG2814	Major facilitator Superfamily
ASPU41_RS09470	COG0739	heme binding
ASPU41_RS09485	COG0746	molybdenum cofactor guanylyltransferase activity
ASPU41_RS09500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ASPU41_RS09520	COG0488	(ABC) transporter
ASPU41_RS09525	COG1132	(ABC) transporter
ASPU41_RS09575	COG0483	inositol monophosphate 1-phosphatase activity
ASPU41_RS09600	COG0045	succinate-CoA ligase (ADP-forming) activity
ASPU41_RS09615	COG0640	Transcriptional regulator
ASPU41_RS09630	COG1942	4-Oxalocrotonate Tautomerase
ASPU41_RS09635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASPU41_RS09645	COG3962	Belongs to the TPP enzyme family
ASPU41_RS09660	COG0673	inositol 2-dehydrogenase activity
ASPU41_RS09665	COG1082	Xylose isomerase domain protein TIM barrel
ASPU41_RS09670	COG2814	Major facilitator Superfamily
ASPU41_RS09680	COG2814	Major facilitator Superfamily
ASPU41_RS09690	COG1172	Belongs to the binding-protein-dependent transport system permease family
ASPU41_RS09700	COG0673	inositol 2-dehydrogenase activity
ASPU41_RS09710	COG0673	inositol 2-dehydrogenase activity
ASPU41_RS09715	COG3718	enzyme involved in inositol metabolism
ASPU41_RS09725	COG0584	glycerophosphoryl diester phosphodiesterase
ASPU41_RS09730	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ASPU41_RS09760	COG1396	sequence-specific DNA binding
ASPU41_RS09775	COG0028	Belongs to the TPP enzyme family
ASPU41_RS09820	COG1401	restriction endodeoxyribonuclease activity
ASPU41_RS09865	COG1063	alcohol dehydrogenase
ASPU41_RS09870	COG1902	pentaerythritol trinitrate reductase activity
ASPU41_RS09895	COG0405	Gamma-glutamyltransferase
ASPU41_RS09925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ASPU41_RS09950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ASPU41_RS09995	COG0366	Alpha amylase catalytic
ASPU41_RS10020	COG4152	abc transporter atp-binding protein
ASPU41_RS10030	COG1254	Belongs to the acylphosphatase family
ASPU41_RS10035	COG0514	ATP-dependent DNA helicase (RecQ)
ASPU41_RS10045	COG3835	regulator
ASPU41_RS10075	COG0477	Major facilitator Superfamily
ASPU41_RS10100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ASPU41_RS10110	COG2072	flavoprotein involved in K transport
ASPU41_RS10140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ASPU41_RS10160	COG0395	ABC-type sugar transport system, permease component
ASPU41_RS10165	COG1175	transmembrane transport
ASPU41_RS10180	COG3684	Belongs to the aldolase LacD family
ASPU41_RS10190	COG0673	inositol 2-dehydrogenase activity
ASPU41_RS10195	COG1349	DNA-binding transcription factor activity
ASPU41_RS10250	COG1302	Protein conserved in bacteria
ASPU41_RS10280	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ASPU41_RS10300	COG0366	Alpha amylase catalytic
ASPU41_RS10310	COG1597	lipid kinase activity
ASPU41_RS10315	COG0028	Belongs to the TPP enzyme family
ASPU41_RS10325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ASPU41_RS10330	COG1113	amino acid transport
ASPU41_RS10350	COG2826	transposase and inactivated derivatives, IS30 family
ASPU41_RS10380	COG3540	Alkaline phosphatase
ASPU41_RS10400	COG4942	peptidase
ASPU41_RS10410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ASPU41_RS10440	COG2072	flavoprotein involved in K transport
ASPU41_RS10455	COG4638	Rieske (2fe-2S)
ASPU41_RS10460	COG0583	DNA-binding transcription factor activity
ASPU41_RS10465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ASPU41_RS10475	COG0302	gtp cyclohydrolase
ASPU41_RS10495	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ASPU41_RS10520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ASPU41_RS10560	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ASPU41_RS10565	COG1012	belongs to the aldehyde dehydrogenase family
ASPU41_RS10615	COG0346	lactoylglutathione lyase activity
ASPU41_RS10625	COG1278	Cold shock
ASPU41_RS10685	COG1473	amidohydrolase
ASPU41_RS10705	COG1609	Transcriptional regulator
ASPU41_RS10720	COG5001	Diguanylate cyclase
ASPU41_RS10720	COG3300	MHYT domain
ASPU41_RS10725	COG3300	MHYT domain
ASPU41_RS10725	COG5001	Diguanylate cyclase
ASPU41_RS10730	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ASPU41_RS10755	COG0318	PFAM AMP-dependent synthetase and ligase
ASPU41_RS10760	COG1028	Short-chain dehydrogenase reductase Sdr
ASPU41_RS10775	COG0477	Major facilitator Superfamily
ASPU41_RS10800	COG0477	Major facilitator Superfamily
ASPU41_RS10805	COG0138	bifunctional purine biosynthesis protein purh
ASPU41_RS10815	COG2838	Isocitrate dehydrogenase
ASPU41_RS10830	COG2815	serine threonine protein kinase
ASPU41_RS10830	COG0515	serine threonine protein kinase
ASPU41_RS10840	COG0673	inositol 2-dehydrogenase activity
ASPU41_RS10850	COG1136	(ABC) transporter
ASPU41_RS10860	COG4213	ABC transporter substrate-binding protein
ASPU41_RS10900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ASPU41_RS10905	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ASPU41_RS10935	COG0180	Tryptophanyl-tRNA synthetase
ASPU41_RS10955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ASPU41_RS10970	COG2009	succinate dehydrogenase
ASPU41_RS10980	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ASPU41_RS10980	COG1473	amidohydrolase
ASPU41_RS10985	COG1846	Transcriptional regulator
ASPU41_RS10990	COG1764	response to oxidative stress
ASPU41_RS10995	COG2130	NADP-dependent
ASPU41_RS11000	COG1744	ABC transporter substrate-binding protein PnrA-like
ASPU41_RS11005	COG3845	ABC transporter
ASPU41_RS11010	COG4603	Belongs to the binding-protein-dependent transport system permease family
ASPU41_RS11015	COG1079	Belongs to the binding-protein-dependent transport system permease family
ASPU41_RS11040	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ASPU41_RS11045	COG3956	TIGRFAM MazG family protein
ASPU41_RS11050	COG0148	phosphopyruvate hydratase activity
ASPU41_RS11075	COG1252	NADH dehydrogenase
ASPU41_RS11110	COG0559	Belongs to the binding-protein-dependent transport system permease family
ASPU41_RS11120	COG0183	Belongs to the thiolase family
ASPU41_RS11125	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ASPU41_RS11130	COG2017	converts alpha-aldose to the beta-anomer
ASPU41_RS11140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ASPU41_RS11150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ASPU41_RS11160	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ASPU41_RS11170	COG1331	Highly conserved protein containing a thioredoxin domain
ASPU41_RS11180	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ASPU41_RS11185	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ASPU41_RS11220	COG0114	fumarate hydratase activity
ASPU41_RS11225	COG0288	reversible hydration of carbon dioxide
ASPU41_RS11235	COG1494	fructose-1,6-bisphosphatase
ASPU41_RS11250	COG1482	cell wall glycoprotein biosynthetic process
ASPU41_RS11310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ASPU41_RS11315	COG1376	ErfK ybiS ycfS ynhG family protein
ASPU41_RS11355	COG0714	Associated with various cellular activities
ASPU41_RS11360	COG0084	hydrolase, TatD family'
ASPU41_RS11365	COG3583	domain protein
ASPU41_RS11370	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ASPU41_RS11375	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ASPU41_RS11380	COG0488	(ABC) transporter
ASPU41_RS11395	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ASPU41_RS11405	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ASPU41_RS11410	COG0193	aminoacyl-tRNA hydrolase activity
ASPU41_RS11420	COG2197	response regulator
ASPU41_RS11440	COG0822	iron-sulfur transferase activity
ASPU41_RS11455	COG0702	epimerase
ASPU41_RS11480	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASPU41_RS11495	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ASPU41_RS11505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASPU41_RS11510	COG1959	2 iron, 2 sulfur cluster binding
ASPU41_RS11575	COG0243	molybdopterin cofactor binding
ASPU41_RS11580	COG2223	nitrite transmembrane transporter activity
ASPU41_RS11585	COG0477	Major facilitator Superfamily
ASPU41_RS11595	COG4770	biotin carboxylase activity
ASPU41_RS11600	COG0424	maF-like protein
ASPU41_RS11615	COG2409	Drug exporters of the RND superfamily
ASPU41_RS11630	COG1823	symporter activity
ASPU41_RS11645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ASPU41_RS11650	COG1028	Short-chain dehydrogenase reductase Sdr
ASPU41_RS11655	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ASPU41_RS11655	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ASPU41_RS11675	COG0714	Associated with various cellular activities
ASPU41_RS11695	COG0631	protein serine/threonine phosphatase activity
ASPU41_RS11715	COG1674	ftsk spoiiie
ASPU41_RS11745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ASPU41_RS11750	COG0492	ferredoxin-NADP+ reductase activity
ASPU41_RS11760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ASPU41_RS11765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ASPU41_RS11780	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ASPU41_RS11805	COG4565	transcriptional regulatory protein
ASPU41_RS11815	COG2851	Citrate transporter
ASPU41_RS11820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ASPU41_RS11825	COG0154	amidase activity
ASPU41_RS11830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ASPU41_RS11845	COG1063	alcohol dehydrogenase
ASPU41_RS11860	COG1228	amidohydrolase
ASPU41_RS11880	COG2873	o-acetylhomoserine
ASPU41_RS11885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ASPU41_RS11915	COG2755	lipolytic protein G-D-S-L family
ASPU41_RS11920	COG0400	carboxylic ester hydrolase activity
ASPU41_RS11935	COG0423	glycine-tRNA ligase activity
ASPU41_RS11945	COG2031	fatty acid transporter
ASPU41_RS11965	COG0277	FAD linked oxidase domain protein
ASPU41_RS11985	COG0358	DNA primase activity
ASPU41_RS12005	COG2814	Major facilitator Superfamily
ASPU41_RS12025	COG0297	glycogen (starch) synthase activity
ASPU41_RS12045	COG0052	Belongs to the universal ribosomal protein uS2 family
ASPU41_RS12050	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ASPU41_RS12055	COG0528	UMP kinase activity
ASPU41_RS12060	COG0233	cytoplasmic translational termination
ASPU41_RS12065	COG0575	Belongs to the CDS family
ASPU41_RS12075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ASPU41_RS12090	COG3275	phosphorelay sensor kinase activity
ASPU41_RS12100	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ASPU41_RS12105	COG1522	sequence-specific DNA binding
ASPU41_RS12115	COG0022	dehydrogenase e1 component
ASPU41_RS12120	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASPU41_RS12130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ASPU41_RS12140	COG1960	acyl-CoA dehydrogenase activity
ASPU41_RS12165	COG4565	transcriptional regulatory protein
ASPU41_RS12170	COG3290	protein histidine kinase activity
ASPU41_RS12195	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ASPU41_RS12200	COG0750	zinc metalloprotease
ASPU41_RS12220	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ASPU41_RS12230	COG0442	prolyl-tRNA aminoacylation
ASPU41_RS12245	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
ASPU41_RS12260	COG0779	Required for maturation of 30S ribosomal subunits
ASPU41_RS12275	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ASPU41_RS12280	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ASPU41_RS12290	COG0590	tRNA wobble adenosine to inosine editing
ASPU41_RS12295	COG3118	belongs to the thioredoxin family
ASPU41_RS12315	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ASPU41_RS12365	COG3483	tryptophan 2,3-dioxygenase activity
ASPU41_RS12375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ASPU41_RS12380	COG1185	polyribonucleotide nucleotidyltransferase activity
ASPU41_RS12385	COG0612	Peptidase, M16
ASPU41_RS12415	COG0318	PFAM AMP-dependent synthetase and ligase
ASPU41_RS12465	COG0521	Mo-molybdopterin cofactor biosynthetic process
ASPU41_RS12475	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ASPU41_RS12500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ASPU41_RS12505	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ASPU41_RS12510	COG1674	ftsk spoiiie
ASPU41_RS12520	COG1058	Belongs to the CinA family
ASPU41_RS12520	COG1546	Belongs to the CinA family
ASPU41_RS12525	COG1396	sequence-specific DNA binding
ASPU41_RS12540	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ASPU41_RS12545	COG2137	regulation of response to DNA damage stimulus
ASPU41_RS12550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASPU41_RS12555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ASPU41_RS12560	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ASPU41_RS12565	COG2813	Specifically methylates the guanine in position
ASPU41_RS12570	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ASPU41_RS12580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ASPU41_RS12590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ASPU41_RS12595	COG0131	Imidazoleglycerol-phosphate dehydratase
ASPU41_RS12600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ASPU41_RS12605	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ASPU41_RS12625	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ASPU41_RS12630	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ASPU41_RS12635	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ASPU41_RS12640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ASPU41_RS12645	COG2261	transglycosylase associated protein
ASPU41_RS12655	COG2814	Major facilitator Superfamily
ASPU41_RS12725	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ASPU41_RS12730	COG0072	phenylalanine-tRNA ligase activity
ASPU41_RS12730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASPU41_RS12770	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ASPU41_RS12775	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ASPU41_RS12780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ASPU41_RS12785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ASPU41_RS12790	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ASPU41_RS12795	COG1438	arginine binding
ASPU41_RS12800	COG0137	argininosuccinate synthase activity
ASPU41_RS12805	COG0165	Argininosuccinate lyase
ASPU41_RS12810	COG0259	pyridoxamine-phosphate oxidase activity
ASPU41_RS12820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ASPU41_RS12820	COG2169	Transcriptional regulator
ASPU41_RS12830	COG2094	Belongs to the DNA glycosylase MPG family
ASPU41_RS12840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ASPU41_RS12850	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ASPU41_RS12895	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ASPU41_RS12900	COG0497	DNA recombination
ASPU41_RS12905	COG0504	CTP synthase activity
ASPU41_RS12910	COG0494	nUDIX hydrolase
ASPU41_RS12935	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ASPU41_RS12940	COG2079	MmgE PrpD family protein
ASPU41_RS12960	COG3290	protein histidine kinase activity
ASPU41_RS12975	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ASPU41_RS12980	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ASPU41_RS12995	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ASPU41_RS13005	COG1160	GTP binding
ASPU41_RS13015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ASPU41_RS13020	COG0509	glycine decarboxylation via glycine cleavage system
ASPU41_RS13050	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ASPU41_RS13060	COG1940	carbohydrate kinase activity
ASPU41_RS13085	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ASPU41_RS13090	COG0515	serine threonine protein kinase
ASPU41_RS13090	COG2815	serine threonine protein kinase
ASPU41_RS13095	COG1388	LysM domain
ASPU41_RS13095	COG3942	CHAP domain
ASPU41_RS13105	COG0142	geranyltranstransferase activity
ASPU41_RS13115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ASPU41_RS13125	COG2001	Belongs to the MraZ family
ASPU41_RS13130	COG0275	rRNA processing
ASPU41_RS13140	COG0768	penicillin binding
ASPU41_RS13145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ASPU41_RS13150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ASPU41_RS13155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ASPU41_RS13160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ASPU41_RS13165	COG0772	Belongs to the SEDS family
ASPU41_RS13170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ASPU41_RS13175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ASPU41_RS13185	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ASPU41_RS13190	COG1496	oxidoreductase activity
ASPU41_RS13200	COG1799	cell septum assembly
ASPU41_RS13215	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ASPU41_RS13240	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ASPU41_RS13245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ASPU41_RS13260	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ASPU41_RS13265	COG0174	glutamine synthetase
ASPU41_RS13270	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ASPU41_RS13295	COG2826	transposase and inactivated derivatives, IS30 family
ASPU41_RS13310	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ASPU41_RS13315	COG0321	lipoyl(octanoyl) transferase activity
ASPU41_RS13330	COG1090	epimerase
ASPU41_RS13335	COG4946	Tricorn protease homolog
ASPU41_RS13335	COG0793	Belongs to the peptidase S41A family
ASPU41_RS13340	COG1764	response to oxidative stress
ASPU41_RS13350	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASPU41_RS13355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASPU41_RS13360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ASPU41_RS13380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ASPU41_RS13390	COG0187	DNA topoisomerase II activity
ASPU41_RS13410	COG1271	oxidase subunit
ASPU41_RS13415	COG1294	oxidase, subunit
ASPU41_RS13420	COG4988	ABC transporter
ASPU41_RS13435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ASPU41_RS13440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ASPU41_RS13440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ASPU41_RS13470	COG0756	dUTP diphosphatase activity
ASPU41_RS13495	COG0569	domain protein
ASPU41_RS13500	COG0531	amino acid
ASPU41_RS13505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ASPU41_RS13510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ASPU41_RS13515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ASPU41_RS13535	COG0667	Aldo Keto reductase
ASPU41_RS13555	COG3845	ABC transporter
ASPU41_RS13565	COG1024	Enoyl-CoA hydratase
ASPU41_RS13565	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASPU41_RS13570	COG0183	Belongs to the thiolase family
ASPU41_RS13575	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ASPU41_RS13600	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ASPU41_RS13610	COG3415	Transposase
ASPU41_RS13610	COG2801	Transposase and inactivated derivatives
ASPU41_RS13620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ASPU41_RS13685	COG0242	peptide deformylase activity
ASPU41_RS13690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ASPU41_RS13700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ASPU41_RS13715	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ASPU41_RS13715	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ASPU41_RS13725	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ASPU41_RS13730	COG0140	phosphoribosyl-ATP diphosphatase activity
ASPU41_RS13735	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ASPU41_RS13740	COG0107	imidazoleglycerol-phosphate synthase activity
ASPU41_RS13750	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ASPU41_RS13770	COG0134	indole-3-glycerol-phosphate synthase activity
ASPU41_RS13775	COG0133	tryptophan synthase activity
ASPU41_RS13780	COG0159	tryptophan synthase activity
ASPU41_RS13785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ASPU41_RS13790	COG0069	glutamate synthase activity
ASPU41_RS13790	COG0070	glutamate synthase
ASPU41_RS13790	COG0067	glutamate synthase
ASPU41_RS13800	COG0469	pyruvate kinase activity
ASPU41_RS13820	COG2801	Transposase and inactivated derivatives
ASPU41_RS13885	COG3321	synthase
ASPU41_RS13885	COG0604	alcohol dehydrogenase
ASPU41_RS13905	COG0179	Fumarylacetoacetate (FAA) hydrolase
ASPU41_RS13950	COG2072	flavoprotein involved in K transport
ASPU41_RS13955	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ASPU41_RS13970	COG3328	transposase activity
ASPU41_RS14000	COG2801	Transposase and inactivated derivatives
ASPU41_RS14020	COG1063	alcohol dehydrogenase
ASPU41_RS14030	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ASPU41_RS14035	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ASPU41_RS14050	COG2801	Transposase and inactivated derivatives
ASPU41_RS14105	COG4974	Belongs to the 'phage' integrase family
ASPU41_RS14110	COG0582	viral genome integration into host DNA
ASPU41_RS14115	COG4974	Belongs to the 'phage' integrase family
ASPU41_RS14125	COG2814	Major facilitator Superfamily
ASPU41_RS14155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ASPU41_RS14160	COG3300	MHYT domain
ASPU41_RS14160	COG5001	Diguanylate cyclase
ASPU41_RS14165	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ASPU41_RS14205	COG0438	transferase activity, transferring glycosyl groups
ASPU41_RS14260	COG5416	Lipopolysaccharide assembly protein A domain
ASPU41_RS14295	COG2801	Transposase and inactivated derivatives
ASPU41_RS14350	COG1278	Cold shock
ASPU41_RS14360	COG2963	transposase activity
ASPU41_RS14365	COG2801	Transposase and inactivated derivatives
ASPU41_RS14380	COG2409	Drug exporters of the RND superfamily
ASPU41_RS14385	COG2801	Transposase and inactivated derivatives
ASPU41_RS14405	COG2801	Transposase and inactivated derivatives
ASPU41_RS14415	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ASPU41_RS14425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ASPU41_RS14430	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ASPU41_RS14435	COG2801	Transposase and inactivated derivatives
ASPU41_RS14490	COG2814	Major facilitator Superfamily
ASPU41_RS14520	COG1960	acyl-CoA dehydrogenase activity
ASPU41_RS14535	COG0733	neurotransmitter:sodium symporter activity
ASPU41_RS14550	COG2188	Transcriptional regulator
ASPU41_RS14555	COG1620	l-lactate permease
ASPU41_RS14560	COG0247	lactate metabolic process
ASPU41_RS14565	COG1139	Iron-sulfur cluster binding protein
ASPU41_RS14570	COG1556	Lactate utilization protein
ASPU41_RS14580	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ASPU41_RS14585	COG0277	FAD linked oxidase domain protein
ASPU41_RS14590	COG1414	Transcriptional regulator
ASPU41_RS14595	COG1793	dna ligase
ASPU41_RS14595	COG3285	dna ligase
ASPU41_RS14605	COG2124	cytochrome p450
ASPU41_RS14615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ASPU41_RS14620	COG2197	response regulator
ASPU41_RS14625	COG2814	Major facilitator Superfamily
ASPU41_RS14630	COG1028	Short-chain dehydrogenase reductase Sdr
ASPU41_RS14645	COG4638	Rieske (2fe-2S)
ASPU41_RS14650	COG0583	DNA-binding transcription factor activity
ASPU41_RS14655	COG3485	protocatechuate 3,4-dioxygenase
ASPU41_RS14660	COG3135	benzoate transporter
ASPU41_RS14665	COG1528	Iron-storage protein
ASPU41_RS14695	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ASPU41_RS14700	COG1937	Protein conserved in bacteria
ASPU41_RS14705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASPU41_RS14715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASPU41_RS14720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ASPU41_RS14730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASPU41_RS14735	COG2814	Major facilitator Superfamily
ASPU41_RS14740	COG2801	Transposase and inactivated derivatives
ASPU41_RS14810	COG1846	Transcriptional regulator
ASPU41_RS14815	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ASPU41_RS14820	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ASPU41_RS14820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ASPU41_RS14845	COG0412	Dienelactone hydrolase
ASPU41_RS14870	COG1643	Atp-dependent helicase
ASPU41_RS14885	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ASPU41_RS14920	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ASPU41_RS14955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASPU41_RS14970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ASPU41_RS14995	COG2801	Transposase and inactivated derivatives
ASPU41_RS15020	COG0667	Aldo Keto reductase
ASPU41_RS15025	COG1621	beta-fructofuranosidase activity
ASPU41_RS15035	COG4608	Belongs to the ABC transporter superfamily
ASPU41_RS15040	COG0444	Belongs to the ABC transporter superfamily
ASPU41_RS15045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASPU41_RS15050	COG0601	transmembrane transport
ASPU41_RS15055	COG0747	negative chemotaxis
ASPU41_RS15065	COG1609	Transcriptional regulator
ASPU41_RS15075	COG1175	transmembrane transport
ASPU41_RS15080	COG0395	ABC-type sugar transport system, permease component
ASPU41_RS15085	COG1621	beta-fructofuranosidase activity
ASPU41_RS15100	COG4974	Belongs to the 'phage' integrase family
ASPU41_RS15105	COG0582	viral genome integration into host DNA
ASPU41_RS15110	COG4974	Belongs to the 'phage' integrase family
ASPU41_RS15125	COG2801	Transposase and inactivated derivatives
ASPU41_RS15180	COG0009	L-threonylcarbamoyladenylate synthase
ASPU41_RS15185	COG1174	glycine betaine transport
ASPU41_RS15195	COG1174	glycine betaine transport
ASPU41_RS15210	COG3608	succinylglutamate desuccinylase aspartoacylase
ASPU41_RS15210	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ASPU41_RS15225	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ASPU41_RS15235	COG3608	succinylglutamate desuccinylase aspartoacylase
ASPU41_RS15235	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ASPU41_RS15255	COG0583	DNA-binding transcription factor activity
ASPU41_RS15275	COG0318	PFAM AMP-dependent synthetase and ligase
ASPU41_RS15280	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ASPU41_RS15300	COG0589	response to stress
ASPU41_RS15310	COG0179	Fumarylacetoacetate (FAA) hydrolase
ASPU41_RS15325	COG2814	Major facilitator Superfamily
ASPU41_RS15330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ASPU41_RS15345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ASPU41_RS15350	COG2050	protein possibly involved in aromatic compounds catabolism
ASPU41_RS15360	COG4552	Acetyltransferase involved in intracellular survival and related
ASPU41_RS15365	COG0539	negative regulation of cytoplasmic translation
ASPU41_RS15380	COG1739	Uncharacterized protein family UPF0029
ASPU41_RS15385	COG0237	dephospho-CoA kinase activity
ASPU41_RS15385	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ASPU41_RS15390	COG0556	nucleotide-excision repair
ASPU41_RS15425	COG4106	trans-aconitate 2-methyltransferase activity
ASPU41_RS15465	COG0322	excinuclease ABC activity
ASPU41_RS15470	COG1660	Displays ATPase and GTPase activities
ASPU41_RS15475	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ASPU41_RS15480	COG1481	regulation of sporulation
ASPU41_RS15485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ASPU41_RS15490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ASPU41_RS15495	COG0126	phosphoglycerate kinase activity
ASPU41_RS15500	COG0149	triose-phosphate isomerase activity
ASPU41_RS15505	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ASPU41_RS15515	COG0363	glucosamine-6-phosphate deaminase activity
ASPU41_RS15530	COG0166	Belongs to the GPI family
ASPU41_RS15535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ASPU41_RS15545	COG0109	protoheme IX farnesyltransferase activity
ASPU41_RS15550	COG1612	heme a metabolic process
ASPU41_RS15555	COG0842	Transport permease protein
ASPU41_RS15560	COG1131	(ABC) transporter
ASPU41_RS15585	COG0396	ATPase activity
ASPU41_RS15590	COG2151	metal-sulfur cluster biosynthetic enzyme
ASPU41_RS15600	COG0318	PFAM AMP-dependent synthetase and ligase
ASPU41_RS15615	COG1122	ATPase activity
ASPU41_RS15620	COG1268	BioY protein
ASPU41_RS15625	COG0488	(ABC) transporter
ASPU41_RS15635	COG2801	Transposase and inactivated derivatives
ASPU41_RS15635	COG3415	Transposase
ASPU41_RS15670	COG1028	Short-chain dehydrogenase reductase Sdr
ASPU41_RS15695	COG1028	Short-chain dehydrogenase reductase Sdr
ASPU41_RS15700	COG3830	Belongs to the UPF0237 family
ASPU41_RS15700	COG0560	Phosphoserine phosphatase
ASPU41_RS15705	COG1119	ATPase activity
ASPU41_RS15720	COG0254	rRNA binding
ASPU41_RS15735	COG2855	membrane
ASPU41_RS15785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ASPU41_RS15790	COG0297	glycogen (starch) synthase activity
ASPU41_RS15805	COG0183	Belongs to the thiolase family
ASPU41_RS15810	COG1028	Short-chain dehydrogenase reductase Sdr
ASPU41_RS15815	COG2030	dehydratase
ASPU41_RS15825	COG0435	Glutathione S-transferase
ASPU41_RS15835	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ASPU41_RS15890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ASPU41_RS15910	COG0656	L-ascorbic acid biosynthetic process
ASPU41_RS15915	COG1968	undecaprenyl-diphosphatase activity
ASPU41_RS15920	COG0215	cysteine-tRNA ligase activity
ASPU41_RS15930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASPU41_RS15935	COG1994	Peptidase M50
ASPU41_RS15935	COG0517	IMP dehydrogenase activity
ASPU41_RS15945	COG1222	aaa ATPase
ASPU41_RS15950	COG4122	O-methyltransferase activity
ASPU41_RS15960	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ASPU41_RS15965	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ASPU41_RS15970	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ASPU41_RS15975	COG0545	Peptidyl-prolyl cis-trans isomerase
ASPU41_RS15995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASPU41_RS16000	COG0805	protein transport
ASPU41_RS16005	COG4581	dead DEAH box helicase
ASPU41_RS16010	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ASPU41_RS16015	COG1216	Glycosyl transferase, family 2
ASPU41_RS16040	COG0823	Involved in the tonB-independent uptake of proteins
ASPU41_RS16040	COG1506	peptidase
ASPU41_RS16040	COG4946	Tricorn protease homolog
ASPU41_RS16045	COG0242	peptide deformylase activity
ASPU41_RS16070	COG3424	synthase
ASPU41_RS16120	COG0723	plastoquinol--plastocyanin reductase activity
ASPU41_RS16120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ASPU41_RS16150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ASPU41_RS16155	COG1845	cytochrome c oxidase, subunit III
ASPU41_RS16160	COG2010	Cytochrome c
ASPU41_RS16165	COG0723	plastoquinol--plastocyanin reductase activity
ASPU41_RS16170	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ASPU41_RS16175	COG2188	Transcriptional regulator
ASPU41_RS16190	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ASPU41_RS16195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ASPU41_RS16215	COG0167	dihydroorotate dehydrogenase activity
ASPU41_RS16225	COG2267	carboxylic ester hydrolase activity
ASPU41_RS16230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ASPU41_RS16235	COG1381	Involved in DNA repair and RecF pathway recombination
ASPU41_RS16240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ASPU41_RS16245	COG3590	peptidase
ASPU41_RS16250	COG4932	domain protein
ASPU41_RS16250	COG5492	domain, Protein
ASPU41_RS16260	COG1316	TRANSCRIPTIONal
ASPU41_RS16265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ASPU41_RS16275	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ASPU41_RS16290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ASPU41_RS16295	COG0484	heat shock protein binding
ASPU41_RS16300	COG1420	regulation of RNA biosynthetic process
ASPU41_RS16315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ASPU41_RS16320	COG0481	GTPase activity
ASPU41_RS16335	COG0268	Binds directly to 16S ribosomal RNA
ASPU41_RS16370	COG2132	Multicopper oxidase
ASPU41_RS16450	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ASPU41_RS16455	COG2217	Heavy metal translocating P-type atpase
ASPU41_RS16470	COG1937	Protein conserved in bacteria
ASPU41_RS16485	COG3103	Sh3 type 3 domain protein
ASPU41_RS16485	COG1388	LysM domain
ASPU41_RS16485	COG0791	NLP P60 protein
ASPU41_RS16510	COG0785	Cytochrome C biogenesis protein
ASPU41_RS16515	COG2132	Multicopper oxidase
ASPU41_RS16575	COG0531	amino acid
ASPU41_RS16590	COG2217	Heavy metal translocating P-type atpase
ASPU41_RS16655	COG4974	Belongs to the 'phage' integrase family
ASPU41_RS16665	COG2161	toxin-antitoxin pair type II binding
ASPU41_RS16695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ASPU41_RS16740	COG2801	Transposase and inactivated derivatives
ASPU41_RS16750	COG0596	Alpha beta hydrolase
ASPU41_RS16810	COG1307	EDD domain protein, DegV family
ASPU41_RS16815	COG0495	leucyl-tRNA aminoacylation
ASPU41_RS16835	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ASPU41_RS16840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ASPU41_RS16845	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ASPU41_RS16850	COG2390	Transcriptional regulator
ASPU41_RS16855	COG0656	L-ascorbic acid biosynthetic process
ASPU41_RS16875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ASPU41_RS16885	COG1758	RNA polymerase activity
ASPU41_RS16890	COG0194	GDP metabolic process
ASPU41_RS16895	COG0194	GDP metabolic process
ASPU41_RS16900	COG0284	orotidine-5'-phosphate decarboxylase activity
ASPU41_RS16905	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ASPU41_RS16910	COG0505	Belongs to the CarA family
ASPU41_RS16920	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ASPU41_RS16925	COG0540	Belongs to the ATCase OTCase family
ASPU41_RS16930	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ASPU41_RS16940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ASPU41_RS16945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ASPU41_RS16955	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ASPU41_RS16965	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ASPU41_RS16970	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ASPU41_RS16985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ASPU41_RS17000	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ASPU41_RS17030	COG1846	Transcriptional regulator
ASPU41_RS17075	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ASPU41_RS17085	COG0124	histidyl-tRNA synthetase
ASPU41_RS17095	COG1196	nuclear chromosome segregation
ASPU41_RS17105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ASPU41_RS17110	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASPU41_RS17115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASPU41_RS17125	COG2255	four-way junction helicase activity
ASPU41_RS17130	COG0632	four-way junction helicase activity
ASPU41_RS17135	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ASPU41_RS17140	COG0217	transcriptional regulatory protein
ASPU41_RS17145	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ASPU41_RS17150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ASPU41_RS17160	COG0454	-acetyltransferase
ASPU41_RS17185	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ASPU41_RS17190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ASPU41_RS17200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ASPU41_RS17205	COG0587	DNA-directed DNA polymerase activity
ASPU41_RS17220	COG1605	Chorismate mutase
ASPU41_RS17220	COG0077	Prephenate dehydratase
ASPU41_RS17230	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASPU41_RS17235	COG2135	peptidase activity
ASPU41_RS17295	COG0586	Pfam SNARE associated Golgi protein
ASPU41_RS17370	COG0405	Gamma-glutamyltransferase
ASPU41_RS17385	COG1132	(ABC) transporter
ASPU41_RS17395	COG0297	glycogen (starch) synthase activity
ASPU41_RS17400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ASPU41_RS17415	COG1253	flavin adenine dinucleotide binding
ASPU41_RS17450	COG2826	transposase and inactivated derivatives, IS30 family
ASPU41_RS17465	COG3384	dioxygenase
ASPU41_RS17480	COG3540	Alkaline phosphatase
ASPU41_RS17505	COG1196	nuclear chromosome segregation
ASPU41_RS17510	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASPU41_RS17515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASPU41_RS17520	COG1780	Probably involved in ribonucleotide reductase function
ASPU41_RS17530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ASPU41_RS17550	COG1012	belongs to the aldehyde dehydrogenase family
ASPU41_RS17585	COG2813	Specifically methylates the guanine in position
ASPU41_RS17595	COG2824	Alkylphosphonate utilization operon protein PhnA
ASPU41_RS17630	COG0799	negative regulation of ribosome biogenesis
ASPU41_RS17640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ASPU41_RS17650	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ASPU41_RS17655	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ASPU41_RS17660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASPU41_RS17665	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ASPU41_RS17670	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ASPU41_RS17675	COG0352	thiamine-phosphate diphosphorylase activity
ASPU41_RS17675	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ASPU41_RS17675	COG0351	phosphomethylpyrimidine kinase
ASPU41_RS17680	COG1530	ribonuclease E activity
ASPU41_RS17690	COG0105	UTP biosynthetic process
ASPU41_RS17700	COG0285	dihydrofolate synthase activity
ASPU41_RS17705	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ASPU41_RS17720	COG1115	amino acid carrier protein
ASPU41_RS17725	COG0525	valine-tRNA ligase activity
ASPU41_RS17730	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ASPU41_RS17735	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ASPU41_RS17740	COG0740	serine-type endopeptidase activity
ASPU41_RS17745	COG0740	serine-type endopeptidase activity
ASPU41_RS17750	COG0544	peptidyl-prolyl cis-trans isomerase activity
ASPU41_RS17790	COG0668	transmembrane transport
ASPU41_RS17810	COG1946	Acyl-CoA thioesterase
ASPU41_RS17820	COG0629	single-stranded DNA binding
ASPU41_RS17830	COG5416	Lipopolysaccharide assembly protein A domain
ASPU41_RS17870	COG0242	peptide deformylase activity
ASPU41_RS17875	COG0596	Alpha beta hydrolase
ASPU41_RS17880	COG2326	polyphosphate kinase activity
ASPU41_RS17925	COG3022	response to hydroperoxide
ASPU41_RS17935	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ASPU41_RS17940	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ASPU41_RS17950	COG1045	serine acetyltransferase
ASPU41_RS17955	COG1028	Short-chain dehydrogenase reductase Sdr
ASPU41_RS17960	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ASPU41_RS17970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ASPU41_RS18010	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ASPU41_RS18025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASPU41_RS18030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ASPU41_RS18035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ASPU41_RS18045	COG4974	Belongs to the 'phage' integrase family
ASPU41_RS18165	COG2826	transposase and inactivated derivatives, IS30 family
ASPU41_RS18200	COG0792	nuclease activity
ASPU41_RS18210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ASPU41_RS18220	COG0681	Belongs to the peptidase S26 family
ASPU41_RS18225	COG0335	large ribosomal subunit rRNA binding
ASPU41_RS18230	COG0336	Belongs to the RNA methyltransferase TrmD family
ASPU41_RS18235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ASPU41_RS18240	COG1837	Belongs to the UPF0109 family
ASPU41_RS18245	COG0228	four-way junction DNA binding
ASPU41_RS18255	COG2514	catechol 2,3-dioxygenase activity
ASPU41_RS18270	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ASPU41_RS18285	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ASPU41_RS18300	COG2814	Major facilitator Superfamily
ASPU41_RS18355	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ASPU41_RS18360	COG0571	ribonuclease III activity
ASPU41_RS18365	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ASPU41_RS18380	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ASPU41_RS18385	COG0300	oxidoreductase activity
ASPU41_RS18405	COG0742	ribosomal rna small subunit methyltransferase
ASPU41_RS18415	COG1461	Dihydroxyacetone kinase
ASPU41_RS18430	COG1088	dTDP-glucose 4,6-dehydratase activity
ASPU41_RS18435	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ASPU41_RS18445	COG1181	Belongs to the D-alanine--D-alanine ligase family
ASPU41_RS18450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ASPU41_RS18460	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ASPU41_RS18465	COG0066	3-isopropylmalate dehydratase activity
ASPU41_RS18470	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ASPU41_RS18475	COG1414	Transcriptional regulator
ASPU41_RS18515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASPU41_RS18520	COG0179	Fumarylacetoacetate (FAA) hydrolase
ASPU41_RS18535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ASPU41_RS18540	COG0473	3-isopropylmalate dehydrogenase activity
ASPU41_RS18560	COG0577	efflux transmembrane transporter activity
ASPU41_RS18560	COG1136	(ABC) transporter
ASPU41_RS18570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ASPU41_RS18575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ASPU41_RS18580	COG0440	acetolactate synthase activity
ASPU41_RS18590	COG0129	dihydroxy-acid dehydratase activity
ASPU41_RS18595	COG0583	DNA-binding transcription factor activity
ASPU41_RS18650	COG0747	negative chemotaxis
ASPU41_RS18655	COG0579	oxidoreductase
ASPU41_RS18660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ASPU41_RS18675	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ASPU41_RS18685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASPU41_RS18695	COG1305	Transglutaminase-like
ASPU41_RS18715	COG1104	cysteine desulfurase activity
ASPU41_RS18725	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ASPU41_RS18730	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ASPU41_RS18745	COG1113	amino acid transport
ASPU41_RS18755	COG0022	dehydrogenase e1 component
ASPU41_RS18760	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASPU41_RS18785	COG0477	Major facilitator Superfamily
ASPU41_RS18815	COG0419	ATPase involved in DNA repair
ASPU41_RS18820	COG0420	3'-5' exonuclease activity
ASPU41_RS18845	COG0586	Pfam SNARE associated Golgi protein
ASPU41_RS18850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ASPU41_RS18855	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ASPU41_RS18860	COG1234	tRNA 3'-trailer cleavage
ASPU41_RS18865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ASPU41_RS18875	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ASPU41_RS18885	COG1335	isochorismatase
ASPU41_RS18905	COG0363	glucosamine-6-phosphate deaminase activity
ASPU41_RS18920	COG1902	pentaerythritol trinitrate reductase activity
ASPU41_RS18935	COG0628	permease
ASPU41_RS18950	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
ASPU41_RS18960	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ASPU41_RS18965	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ASPU41_RS18975	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ASPU41_RS18980	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ASPU41_RS18985	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ASPU41_RS18990	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ASPU41_RS18995	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ASPU41_RS19000	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ASPU41_RS19005	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ASPU41_RS19010	COG0356	it plays a direct role in the translocation of protons across the membrane
ASPU41_RS19020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ASPU41_RS19025	COG1086	Polysaccharide biosynthesis protein
ASPU41_RS19040	COG0009	L-threonylcarbamoyladenylate synthase
ASPU41_RS19045	COG2890	protein-(glutamine-N5) methyltransferase activity
ASPU41_RS19050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ASPU41_RS19060	COG0083	homoserine kinase activity
ASPU41_RS19065	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ASPU41_RS19070	COG0460	homoserine dehydrogenase
ASPU41_RS19075	COG0019	diaminopimelate decarboxylase activity
ASPU41_RS19080	COG0018	arginyl-trna synthetase
ASPU41_RS19105	COG0706	membrane insertase activity
ASPU41_RS19130	COG1643	Atp-dependent helicase
ASPU41_RS19135	COG0537	adenosine 5'-monophosphoramidase activity
ASPU41_RS19140	COG1064	alcohol dehydrogenase
ASPU41_RS19150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ASPU41_RS19180	COG1121	(ABC) transporter
ASPU41_RS19195	COG1253	flavin adenine dinucleotide binding
ASPU41_RS19205	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASPU41_RS19205	COG0567	Dehydrogenase, E1 component
ASPU41_RS19230	COG1595	DNA-templated transcription, initiation
ASPU41_RS19240	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ASPU41_RS19250	COG0483	inositol monophosphate 1-phosphatase activity
ASPU41_RS19255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ASPU41_RS19270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ASPU41_RS19275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ASPU41_RS19290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ASPU41_RS19305	COG2884	Cell division ATP-binding protein ftsE
ASPU41_RS19310	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ASPU41_RS19395	COG2963	transposase activity
ASPU41_RS19410	COG1216	Glycosyl transferase, family 2
ASPU41_RS19450	COG1216	Glycosyl transferase, family 2
ASPU41_RS19460	COG1674	ftsk spoiiie
ASPU41_RS19480	COG2902	Dehydrogenase
ASPU41_RS19515	COG0653	protein targeting
ASPU41_RS19525	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ASPU41_RS19535	COG5401	PFAM Sporulation and spore germination
ASPU41_RS19540	COG5002	protein histidine kinase activity
ASPU41_RS19575	COG0601	transmembrane transport
ASPU41_RS19585	COG0482	sulfurtransferase activity
ASPU41_RS19600	COG0697	spore germination
ASPU41_RS19625	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ASPU41_RS19630	COG1595	DNA-templated transcription, initiation
ASPU41_RS19640	COG3265	gluconokinase activity
ASPU41_RS19650	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ASPU41_RS19660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ASPU41_RS19670	COG1842	Phage shock protein A
ASPU41_RS19675	COG0415	Belongs to the DNA photolyase family
ASPU41_RS19690	COG1615	UPF0182 protein
ASPU41_RS19695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ASPU41_RS19715	COG2816	NAD+ diphosphatase activity
ASPU41_RS19725	COG0210	DNA helicase
ASPU41_RS19745	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ASPU41_RS19750	COG2011	ABC-type metal ion transport system permease component
ASPU41_RS19760	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ASPU41_RS19770	COG0113	porphobilinogen synthase activity
ASPU41_RS19780	COG0181	hydroxymethylbilane synthase activity
ASPU41_RS19785	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ASPU41_RS19790	COG3253	May function as heme-dependent peroxidase
ASPU41_RS19805	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ASPU41_RS19810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ASPU41_RS19840	COG2022	thiamine diphosphate biosynthetic process
ASPU41_RS19850	COG2022	thiamine diphosphate biosynthetic process
ASPU41_RS19850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ASPU41_RS19855	COG0352	thiamine-phosphate diphosphorylase activity
ASPU41_RS19870	COG0513	Belongs to the DEAD box helicase family
ASPU41_RS19875	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ASPU41_RS19880	COG0613	PHP domain protein
ASPU41_RS19885	COG0006	proline dipeptidase activity
ASPU41_RS19895	COG2239	Acts as a magnesium transporter
ASPU41_RS19905	COG0489	protein tyrosine kinase activity
ASPU41_RS19905	COG2151	metal-sulfur cluster biosynthetic enzyme
ASPU41_RS19910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASPU41_RS20025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASPU41_RS20050	COG0444	Belongs to the ABC transporter superfamily
ASPU41_RS20190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ASPU41_RS20445	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ASPU41_RS20920	COG1322	Protein conserved in bacteria
ASPU41_RS21175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ASPU41_RS21175	COG0519	Catalyzes the synthesis of GMP from XMP
ASPU41_RS21280	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ASPU41_RS21400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ASPU41_RS21605	COG0372	Belongs to the citrate synthase family
ASPU41_RS21650	COG4608	Belongs to the ABC transporter superfamily
ASPU41_RS21745	COG1570	exodeoxyribonuclease VII activity