locus-tag	class	description
ATC04_RS00110	COG4977	sequence-specific DNA binding
ATC04_RS00140	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ATC04_RS00145	COG3590	peptidase
ATC04_RS00175	COG1476	TRANSCRIPTIONal
ATC04_RS00200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ATC04_RS00225	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ATC04_RS00235	COG0302	gtp cyclohydrolase
ATC04_RS00240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ATC04_RS00250	COG0037	tRNA processing
ATC04_RS00260	COG2027	D-alanyl-D-alanine carboxypeptidase
ATC04_RS00265	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ATC04_RS00280	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ATC04_RS00305	COG0561	phosphatase activity
ATC04_RS00310	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ATC04_RS00330	COG0154	amidase activity
ATC04_RS00335	COG3104	oligopeptide transport
ATC04_RS00340	COG3655	Transcriptional regulator
ATC04_RS00355	COG0033	Phosphoglucomutase
ATC04_RS00360	COG0833	amino acid
ATC04_RS00365	COG1012	belongs to the aldehyde dehydrogenase family
ATC04_RS00380	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ATC04_RS00385	COG0352	thiamine-phosphate diphosphorylase activity
ATC04_RS00390	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ATC04_RS00390	COG0351	phosphomethylpyrimidine kinase
ATC04_RS00390	COG0352	thiamine-phosphate diphosphorylase activity
ATC04_RS00395	COG2233	PERMEase
ATC04_RS00400	COG0477	Major facilitator Superfamily
ATC04_RS00410	COG1053	succinate dehydrogenase
ATC04_RS00415	COG0477	Major facilitator Superfamily
ATC04_RS00425	COG1053	succinate dehydrogenase
ATC04_RS00430	COG1414	Transcriptional regulator
ATC04_RS00455	COG0561	phosphatase activity
ATC04_RS00460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ATC04_RS00470	COG1024	Enoyl-CoA hydratase
ATC04_RS00485	COG0412	Dienelactone hydrolase
ATC04_RS00490	COG1957	nucleoside hydrolase
ATC04_RS00495	COG1609	Transcriptional regulator
ATC04_RS00520	COG1716	ATPase activity
ATC04_RS00540	COG0515	serine threonine protein kinase
ATC04_RS00545	COG2815	serine threonine protein kinase
ATC04_RS00545	COG0515	serine threonine protein kinase
ATC04_RS00555	COG3764	Sortase (surface protein transpeptidase)
ATC04_RS00565	COG2076	Multidrug Resistance protein
ATC04_RS00570	COG0583	DNA-binding transcription factor activity
ATC04_RS00585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ATC04_RS00600	COG0385	Bile acid
ATC04_RS00620	COG3266	domain, Protein
ATC04_RS00625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ATC04_RS00630	COG0187	DNA topoisomerase II activity
ATC04_RS00635	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
ATC04_RS00640	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ATC04_RS00645	COG0592	DNA-directed DNA polymerase activity
ATC04_RS00650	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ATC04_RS00660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ATC04_RS00665	COG0706	membrane insertase activity
ATC04_RS00675	COG0357	Ribosomal RNA small subunit methyltransferase G
ATC04_RS00680	COG1192	Involved in chromosome partitioning
ATC04_RS00685	COG1475	DNA binding
ATC04_RS00690	COG3118	belongs to the thioredoxin family
ATC04_RS00695	COG0492	ferredoxin-NADP+ reductase activity
ATC04_RS00715	COG0617	tRNA 3'-terminal CCA addition
ATC04_RS00720	COG1260	myo-inositol-1-phosphate synthase
ATC04_RS00740	COG1216	Glycosyl transferase, family 2
ATC04_RS00740	COG1442	glycosyl transferase family 8
ATC04_RS00745	COG2089	acid synthase
ATC04_RS00780	COG4585	Histidine kinase
ATC04_RS00785	COG2197	response regulator
ATC04_RS00795	COG1362	aminopeptidase activity
ATC04_RS00810	COG0579	oxidoreductase
ATC04_RS00815	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ATC04_RS00815	COG2755	lipolytic protein G-D-S-L family
ATC04_RS00820	COG0360	Binds together with S18 to 16S ribosomal RNA
ATC04_RS00830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ATC04_RS00835	COG0359	binds to the 23S rRNA
ATC04_RS00840	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ATC04_RS00875	COG2133	pyrroloquinoline quinone binding
ATC04_RS00885	COG0318	PFAM AMP-dependent synthetase and ligase
ATC04_RS00920	COG1476	TRANSCRIPTIONal
ATC04_RS00925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ATC04_RS00930	COG0305	Participates in initiation and elongation during chromosome replication
ATC04_RS00940	COG0477	Major facilitator Superfamily
ATC04_RS00960	COG1846	Transcriptional regulator
ATC04_RS00975	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_RS01010	COG2351	hydroxyisourate hydrolase activity
ATC04_RS01020	COG2233	PERMEase
ATC04_RS01025	COG1609	Transcriptional regulator
ATC04_RS01040	COG2160	L-arabinose isomerase activity
ATC04_RS01045	COG4213	ABC transporter substrate-binding protein
ATC04_RS01055	COG4214	carbohydrate transport
ATC04_RS01060	COG2017	converts alpha-aldose to the beta-anomer
ATC04_RS01070	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ATC04_RS01095	COG0531	amino acid
ATC04_RS01115	COG4221	oxidoreductase activity
ATC04_RS01130	COG2814	Major facilitator Superfamily
ATC04_RS01135	COG1113	amino acid transport
ATC04_RS01145	COG1940	carbohydrate kinase activity
ATC04_RS01155	COG2217	Heavy metal translocating P-type atpase
ATC04_RS01160	COG1132	(ABC) transporter
ATC04_RS01165	COG1053	succinate dehydrogenase
ATC04_RS01185	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ATC04_RS01195	COG3257	ureidoglycine aminohydrolase activity
ATC04_RS01210	COG0346	lactoylglutathione lyase activity
ATC04_RS01225	COG2267	carboxylic ester hydrolase activity
ATC04_RS01230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ATC04_RS01255	COG1024	Enoyl-CoA hydratase
ATC04_RS01255	COG1250	3-hydroxyacyl-CoA dehydrogenase
ATC04_RS01260	COG0318	PFAM AMP-dependent synthetase and ligase
ATC04_RS01270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ATC04_RS01275	COG0798	PFAM Bile acid sodium symporter
ATC04_RS01290	COG1309	transcriptional regulator
ATC04_RS01295	COG2267	carboxylic ester hydrolase activity
ATC04_RS01320	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_RS01325	COG0477	Major facilitator Superfamily
ATC04_RS01330	COG0477	Major facilitator Superfamily
ATC04_RS01335	COG0183	Belongs to the thiolase family
ATC04_RS01365	COG0477	Major facilitator Superfamily
ATC04_RS01375	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_RS01390	COG0411	ABC transporter
ATC04_RS01405	COG0183	Belongs to the thiolase family
ATC04_RS01430	COG1960	acyl-CoA dehydrogenase activity
ATC04_RS01435	COG1960	acyl-CoA dehydrogenase activity
ATC04_RS01440	COG1960	acyl-CoA dehydrogenase activity
ATC04_RS01445	COG1024	Enoyl-CoA hydratase
ATC04_RS01450	COG1960	acyl-CoA dehydrogenase activity
ATC04_RS01460	COG0183	Belongs to the thiolase family
ATC04_RS01465	COG0477	Major facilitator Superfamily
ATC04_RS01480	COG2070	2-Nitropropane dioxygenase
ATC04_RS01495	COG1024	Enoyl-CoA hydratase
ATC04_RS01500	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_RS01515	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ATC04_RS01545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ATC04_RS01550	COG4569	acetaldehyde dehydrogenase (acetylating) activity
ATC04_RS01560	COG1414	Transcriptional regulator
ATC04_RS01565	COG3012	SEC-C Motif Domain Protein
ATC04_RS01580	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ATC04_RS01590	COG2186	Transcriptional regulator
ATC04_RS01595	COG0747	negative chemotaxis
ATC04_RS01600	COG0601	transmembrane transport
ATC04_RS01605	COG0444	Belongs to the ABC transporter superfamily
ATC04_RS01610	COG4608	Belongs to the ABC transporter superfamily
ATC04_RS01615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ATC04_RS01620	COG1940	carbohydrate kinase activity
ATC04_RS01625	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ATC04_RS01655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ATC04_RS01675	COG1063	alcohol dehydrogenase
ATC04_RS01680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ATC04_RS01685	COG1414	Transcriptional regulator
ATC04_RS01695	COG0477	Major facilitator Superfamily
ATC04_RS01705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ATC04_RS01725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ATC04_RS01775	COG0318	PFAM AMP-dependent synthetase and ligase
ATC04_RS01790	COG2200	EAL domain
ATC04_RS01790	COG2199	diguanylate cyclase activity
ATC04_RS01790	COG2203	Gaf domain
ATC04_RS01800	COG0659	secondary active sulfate transmembrane transporter activity
ATC04_RS01815	COG1929	Belongs to the glycerate kinase type-1 family
ATC04_RS01820	COG2267	carboxylic ester hydrolase activity
ATC04_RS01870	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ATC04_RS01890	COG0366	Alpha amylase catalytic
ATC04_RS01895	COG0395	ABC-type sugar transport system, permease component
ATC04_RS01915	COG0738	Major facilitator superfamily
ATC04_RS01940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ATC04_RS01945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ATC04_RS01965	COG1278	Cold shock
ATC04_RS01985	COG1953	Uracil, thiamine, allantoin
ATC04_RS01990	COG3622	Belongs to the hyi family
ATC04_RS01995	COG2084	Dehydrogenase
ATC04_RS02000	COG3960	tartronate-semialdehyde synthase activity
ATC04_RS02005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ATC04_RS02015	COG1295	ribonuclease BN
ATC04_RS02035	COG2855	membrane
ATC04_RS02050	COG2205	protein histidine kinase activity
ATC04_RS02055	COG0745	RESPONSE REGULATOR receiver
ATC04_RS02065	COG2755	lipolytic protein G-D-S-L family
ATC04_RS02065	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ATC04_RS02105	COG2066	Belongs to the glutaminase family
ATC04_RS02130	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_RS02135	COG0574	Belongs to the PEP-utilizing enzyme family
ATC04_RS02135	COG3848	Pyruvate phosphate dikinase
ATC04_RS02140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ATC04_RS02140	COG0574	Belongs to the PEP-utilizing enzyme family
ATC04_RS02150	COG1414	Transcriptional regulator
ATC04_RS02170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ATC04_RS02175	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ATC04_RS02205	COG1122	ATPase activity
ATC04_RS02230	COG2801	Transposase and inactivated derivatives
ATC04_RS02265	COG2963	transposase activity
ATC04_RS02290	COG2508	Transcriptional regulator
ATC04_RS02300	COG0477	Major facilitator Superfamily
ATC04_RS02315	COG0028	Belongs to the TPP enzyme family
ATC04_RS02320	COG1012	belongs to the aldehyde dehydrogenase family
ATC04_RS02345	COG0415	Belongs to the DNA photolyase family
ATC04_RS02360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ATC04_RS02370	COG1012	belongs to the aldehyde dehydrogenase family
ATC04_RS02380	COG1793	dna ligase
ATC04_RS02380	COG3285	dna ligase
ATC04_RS02385	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ATC04_RS02400	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_RS02425	COG1335	isochorismatase
ATC04_RS02435	COG0531	amino acid
ATC04_RS02440	COG2323	membrane
ATC04_RS02450	COG2154	pterin-4-alpha-carbinolamine dehydratase
ATC04_RS02475	COG0501	Belongs to the peptidase M48B family
ATC04_RS02505	COG1960	acyl-CoA dehydrogenase activity
ATC04_RS02515	COG1309	transcriptional regulator
ATC04_RS02535	COG1012	belongs to the aldehyde dehydrogenase family
ATC04_RS02540	COG0477	Major facilitator Superfamily
ATC04_RS02570	COG2030	dehydratase
ATC04_RS02580	COG1960	acyl-CoA dehydrogenase activity
ATC04_RS02585	COG1960	acyl-CoA dehydrogenase activity
ATC04_RS02595	COG0318	PFAM AMP-dependent synthetase and ligase
ATC04_RS02600	COG2030	dehydratase
ATC04_RS02630	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ATC04_RS02640	COG0583	DNA-binding transcription factor activity
ATC04_RS02665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ATC04_RS02670	COG0601	transmembrane transport
ATC04_RS02675	COG0747	negative chemotaxis
ATC04_RS02685	COG1266	CAAX protease self-immunity
ATC04_RS02690	COG2814	Major facilitator Superfamily
ATC04_RS02700	COG0534	Mate efflux family protein
ATC04_RS02710	COG0477	Major facilitator Superfamily
ATC04_RS02730	COG0531	amino acid
ATC04_RS02735	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ATC04_RS02755	COG2154	pterin-4-alpha-carbinolamine dehydratase
ATC04_RS02760	COG0531	amino acid
ATC04_RS02765	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ATC04_RS02775	COG1113	amino acid transport
ATC04_RS02785	COG1289	transmembrane transporter activity
ATC04_RS02805	COG1937	Protein conserved in bacteria
ATC04_RS02835	COG2807	transmembrane transport
ATC04_RS02880	COG1842	Phage shock protein A
ATC04_RS02900	COG3850	Histidine kinase
ATC04_RS02925	COG1607	acyl-coa hydrolase
ATC04_RS02930	COG2066	Belongs to the glutaminase family
ATC04_RS02970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ATC04_RS02975	COG2957	Belongs to the agmatine deiminase family
ATC04_RS03015	COG2226	methyltransferase
ATC04_RS03020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ATC04_RS03025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ATC04_RS03040	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ATC04_RS03045	COG0436	Aminotransferase
ATC04_RS03060	COG1228	amidohydrolase
ATC04_RS03065	COG0006	proline dipeptidase activity
ATC04_RS03085	COG1131	(ABC) transporter
ATC04_RS03095	COG4585	Histidine kinase
ATC04_RS03100	COG2197	response regulator
ATC04_RS03115	COG0318	PFAM AMP-dependent synthetase and ligase
ATC04_RS03130	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ATC04_RS03140	COG2233	PERMEase
ATC04_RS03160	COG0277	FAD linked oxidase domain protein
ATC04_RS03170	COG0667	Aldo Keto reductase
ATC04_RS03180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ATC04_RS03180	COG1648	precorrin-2 dehydrogenase activity
ATC04_RS03185	COG2146	nitrite reductase [NAD(P)H] activity
ATC04_RS03185	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ATC04_RS03200	COG0243	molybdopterin cofactor binding
ATC04_RS03205	COG2223	nitrite transmembrane transporter activity
ATC04_RS03215	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ATC04_RS03235	COG1950	PFAM Membrane protein of
ATC04_RS03240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ATC04_RS03250	COG0022	dehydrogenase e1 component
ATC04_RS03255	COG0508	dehydrogenase complex catalyzes the overall conversion of
ATC04_RS03260	COG1506	peptidase
ATC04_RS03260	COG0823	Involved in the tonB-independent uptake of proteins
ATC04_RS03270	COG1027	Aspartate ammonia-lyase
ATC04_RS03280	COG2186	Transcriptional regulator
ATC04_RS03295	COG0028	Belongs to the TPP enzyme family
ATC04_RS03300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ATC04_RS03305	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ATC04_RS03310	COG0588	phosphoglycerate mutase activity
ATC04_RS03320	COG0183	Belongs to the thiolase family
ATC04_RS03340	COG1414	Transcriptional regulator
ATC04_RS03395	COG2814	Major facilitator Superfamily
ATC04_RS03410	COG0318	PFAM AMP-dependent synthetase and ligase
ATC04_RS03430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ATC04_RS03450	COG1733	regulation of RNA biosynthetic process
ATC04_RS03460	COG0477	Major facilitator Superfamily
ATC04_RS03475	COG2149	membrane
ATC04_RS03480	COG1960	acyl-CoA dehydrogenase activity
ATC04_RS03495	COG2855	membrane
ATC04_RS03500	COG0583	DNA-binding transcription factor activity
ATC04_RS03510	COG0583	DNA-binding transcription factor activity
ATC04_RS03520	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_RS03525	COG0477	Major facilitator Superfamily
ATC04_RS03530	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ATC04_RS03535	COG1082	Xylose isomerase domain protein TIM barrel
ATC04_RS03535	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ATC04_RS03540	COG1414	Transcriptional regulator
ATC04_RS03545	COG2050	protein possibly involved in aromatic compounds catabolism
ATC04_RS03555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ATC04_RS03585	COG1113	amino acid transport
ATC04_RS03590	COG2301	Belongs to the HpcH HpaI aldolase family
ATC04_RS03595	COG1115	amino acid carrier protein
ATC04_RS03600	COG0179	Fumarylacetoacetate (FAA) hydrolase
ATC04_RS03605	COG1174	glycine betaine transport
ATC04_RS03615	COG1174	glycine betaine transport
ATC04_RS03640	COG1556	Lactate utilization protein
ATC04_RS03645	COG1139	Iron-sulfur cluster binding protein
ATC04_RS03650	COG0247	lactate metabolic process
ATC04_RS03655	COG1620	l-lactate permease
ATC04_RS03660	COG2188	Transcriptional regulator
ATC04_RS03680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ATC04_RS03695	COG2146	nitrite reductase [NAD(P)H] activity
ATC04_RS03705	COG2211	Major facilitator Superfamily
ATC04_RS03715	COG1522	sequence-specific DNA binding
ATC04_RS03725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ATC04_RS03730	COG0569	domain protein
ATC04_RS03770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ATC04_RS03790	COG0789	Transcriptional regulator
ATC04_RS03820	COG1121	(ABC) transporter
ATC04_RS03825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ATC04_RS03830	COG3639	organic phosphonate transmembrane transporter activity
ATC04_RS03850	COG2188	Transcriptional regulator
ATC04_RS03855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ATC04_RS03860	COG1321	iron dependent repressor
ATC04_RS03865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ATC04_RS03885	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ATC04_RS03890	COG2986	histidine ammonia-lyase
ATC04_RS03905	COG0783	Belongs to the Dps family
ATC04_RS03915	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_RS03925	COG4948	Mandelate Racemase Muconate Lactonizing
ATC04_RS03950	COG1172	Belongs to the binding-protein-dependent transport system permease family
ATC04_RS03955	COG1879	ABC-type sugar transport system periplasmic component
ATC04_RS03960	COG2186	Transcriptional regulator
ATC04_RS03965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ATC04_RS03980	COG2814	Major facilitator Superfamily
ATC04_RS04000	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_RS04005	COG1063	alcohol dehydrogenase
ATC04_RS04015	COG1404	Belongs to the peptidase S8 family
ATC04_RS04030	COG3191	aminopeptidase activity
ATC04_RS04055	COG2365	Tyrosine phosphatase family
ATC04_RS04070	COG0561	phosphatase activity
ATC04_RS04115	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ATC04_RS04125	COG1012	belongs to the aldehyde dehydrogenase family
ATC04_RS04140	COG0789	Transcriptional regulator
ATC04_RS04160	COG4152	abc transporter atp-binding protein
ATC04_RS04165	COG2197	response regulator
ATC04_RS04170	COG4585	Histidine kinase
ATC04_RS04180	COG0135	phosphoribosylanthranilate isomerase activity
ATC04_RS04190	COG4988	ABC transporter
ATC04_RS04195	COG1132	(ABC) transporter
ATC04_RS04200	COG0069	glutamate synthase activity
ATC04_RS04210	COG0583	DNA-binding transcription factor activity
ATC04_RS04235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ATC04_RS04240	COG1278	Cold shock
ATC04_RS04245	COG0477	Major facilitator Superfamily
ATC04_RS04260	COG2860	membrane
ATC04_RS04270	COG4946	Tricorn protease homolog
ATC04_RS04270	COG1506	peptidase
ATC04_RS04270	COG0823	Involved in the tonB-independent uptake of proteins
ATC04_RS04290	COG1528	Iron-storage protein
ATC04_RS04300	COG2197	response regulator
ATC04_RS04325	COG1012	belongs to the aldehyde dehydrogenase family
ATC04_RS04330	COG0667	Aldo Keto reductase
ATC04_RS04335	COG2267	carboxylic ester hydrolase activity
ATC04_RS04340	COG1643	Atp-dependent helicase
ATC04_RS04345	COG1960	acyl-CoA dehydrogenase activity
ATC04_RS04350	COG1309	transcriptional regulator
ATC04_RS04395	COG1136	(ABC) transporter
ATC04_RS04410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ATC04_RS04415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ATC04_RS04420	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ATC04_RS04425	COG1120	ATPase activity
ATC04_RS04435	COG1132	(ABC) transporter
ATC04_RS04450	COG0435	Glutathione S-transferase
ATC04_RS04460	COG0328	RNA-DNA hybrid ribonuclease activity
ATC04_RS04465	COG0531	amino acid
ATC04_RS04480	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ATC04_RS04480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ATC04_RS04485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ATC04_RS04490	COG0509	glycine decarboxylation via glycine cleavage system
ATC04_RS04495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ATC04_RS04505	COG2239	Acts as a magnesium transporter
ATC04_RS04510	COG1902	pentaerythritol trinitrate reductase activity
ATC04_RS04545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ATC04_RS04560	COG3226	Transcriptional regulator
ATC04_RS04590	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ATC04_RS04610	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ATC04_RS04625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ATC04_RS04675	COG2801	Transposase and inactivated derivatives
ATC04_RS04675	COG3415	Transposase
ATC04_RS04680	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ATC04_RS04700	COG3842	ATPase activity
ATC04_RS04705	COG1176	ABC-type spermidine putrescine transport system, permease component I
ATC04_RS04720	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ATC04_RS04725	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ATC04_RS04730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ATC04_RS04740	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_RS04745	COG0776	regulation of translation
ATC04_RS04750	COG0776	regulation of translation
ATC04_RS04765	COG2847	Copper chaperone PCu(A)C
ATC04_RS04790	COG2814	Major facilitator Superfamily
ATC04_RS04800	COG0433	COG0433 Predicted ATPase
ATC04_RS04805	COG1126	abc transporter atp-binding protein
ATC04_RS04810	COG0765	amino acid transport
ATC04_RS04815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ATC04_RS04835	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ATC04_RS04835	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ATC04_RS04850	COG0717	Belongs to the dCTP deaminase family
ATC04_RS04860	COG2111	Na H antiporter
ATC04_RS04860	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ATC04_RS04865	COG1006	Multisubunit Na H antiporter MnhC subunit
ATC04_RS04870	COG0651	ATP synthesis coupled electron transport
ATC04_RS04875	COG1863	multisubunit Na H antiporter MnhE subunit
ATC04_RS04885	COG1320	monovalent cation:proton antiporter activity
ATC04_RS04895	COG4721	ABC-type cobalt transport system, permease component
ATC04_RS04900	COG1122	ATPase activity
ATC04_RS04910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ATC04_RS04930	COG1280	lysine exporter protein (LysE YggA)
ATC04_RS04935	COG1846	Transcriptional regulator
ATC04_RS04940	COG2409	Drug exporters of the RND superfamily
ATC04_RS04960	COG0443	Heat shock 70 kDa protein
ATC04_RS04965	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ATC04_RS04970	COG0484	heat shock protein binding
ATC04_RS04975	COG0789	Transcriptional regulator
ATC04_RS04985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ATC04_RS04990	COG3304	Inner membrane component domain
ATC04_RS05020	COG2197	response regulator
ATC04_RS05025	COG3547	Transposase (IS116 IS110 IS902 family)
ATC04_RS05030	COG3547	Transposase (IS116 IS110 IS902 family)
ATC04_RS05040	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ATC04_RS05065	COG0151	Belongs to the GarS family
ATC04_RS05070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ATC04_RS05075	COG1132	(ABC) transporter
ATC04_RS05080	COG1132	(ABC) transporter
ATC04_RS05090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ATC04_RS05095	COG0251	oxidation-reduction process
ATC04_RS05110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ATC04_RS05115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ATC04_RS05125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ATC04_RS05135	COG0494	nUDIX hydrolase
ATC04_RS05180	COG1205	dead DEAH box helicase
ATC04_RS05180	COG1111	helicase
ATC04_RS05190	COG1054	Belongs to the UPF0176 family
ATC04_RS05210	COG1754	DNA topoisomerase type I activity
ATC04_RS05210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ATC04_RS05215	COG0248	Ppx GppA phosphatase
ATC04_RS05220	COG1082	Xylose isomerase domain protein TIM barrel
ATC04_RS05235	COG0569	domain protein
ATC04_RS05240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ATC04_RS05245	COG0123	including yeast histone deacetylase and acetoin utilization protein
ATC04_RS05250	COG0640	Transcriptional regulator
ATC04_RS05255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ATC04_RS05275	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ATC04_RS05285	COG0406	alpha-ribazole phosphatase activity
ATC04_RS05290	COG3118	belongs to the thioredoxin family
ATC04_RS05295	COG0785	Cytochrome C biogenesis protein
ATC04_RS05305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ATC04_RS05330	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ATC04_RS05335	COG0477	Major facilitator Superfamily
ATC04_RS05345	COG1024	Enoyl-CoA hydratase
ATC04_RS05350	COG1250	3-hydroxyacyl-CoA dehydrogenase
ATC04_RS05360	COG1584	GPR1 FUN34 yaaH family protein
ATC04_RS05390	COG2050	protein possibly involved in aromatic compounds catabolism
ATC04_RS05395	COG1012	belongs to the aldehyde dehydrogenase family
ATC04_RS05395	COG2030	dehydratase
ATC04_RS05415	COG2050	protein possibly involved in aromatic compounds catabolism
ATC04_RS05420	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ATC04_RS05430	COG0765	amino acid transport
ATC04_RS05435	COG1126	abc transporter atp-binding protein
ATC04_RS05440	COG2259	Doxx family
ATC04_RS05445	COG3396	Phenylacetate-CoA oxygenase
ATC04_RS05450	COG3460	Phenylacetate-CoA oxygenase
ATC04_RS05455	COG3396	Phenylacetate-CoA oxygenase
ATC04_RS05460	COG2151	metal-sulfur cluster biosynthetic enzyme
ATC04_RS05465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ATC04_RS05470	COG1024	Enoyl-CoA hydratase
ATC04_RS05475	COG1522	sequence-specific DNA binding
ATC04_RS05485	COG0022	dehydrogenase e1 component
ATC04_RS05490	COG0508	dehydrogenase complex catalyzes the overall conversion of
ATC04_RS05505	COG4948	Mandelate Racemase Muconate Lactonizing
ATC04_RS05515	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ATC04_RS05520	COG1126	abc transporter atp-binding protein
ATC04_RS05525	COG0765	amino acid transport
ATC04_RS05540	COG0142	geranyltranstransferase activity
ATC04_RS05560	COG0733	neurotransmitter:sodium symporter activity
ATC04_RS05575	COG0501	Belongs to the peptidase M48B family
ATC04_RS05580	COG1666	GTP binding
ATC04_RS05590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ATC04_RS05705	COG1846	Transcriptional regulator
ATC04_RS05710	COG0305	Participates in initiation and elongation during chromosome replication
ATC04_RS05810	COG0739	heme binding
ATC04_RS05875	COG2357	RelA SpoT domain protein
ATC04_RS05905	COG2030	dehydratase
ATC04_RS05915	COG0738	Major facilitator superfamily
ATC04_RS05920	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ATC04_RS05925	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ATC04_RS05940	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ATC04_RS05950	COG0494	nUDIX hydrolase
ATC04_RS05950	COG0406	alpha-ribazole phosphatase activity
ATC04_RS05955	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ATC04_RS05960	COG0456	acetyltransferase
ATC04_RS05965	COG0745	RESPONSE REGULATOR receiver
ATC04_RS05975	COG3485	protocatechuate 3,4-dioxygenase
ATC04_RS06015	COG0436	Aminotransferase
ATC04_RS06025	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ATC04_RS06030	COG0250	Participates in transcription elongation, termination and antitermination
ATC04_RS06035	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ATC04_RS06040	COG0081	regulation of translation
ATC04_RS06045	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ATC04_RS06050	COG0222	ribosome binding
ATC04_RS06055	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ATC04_RS06065	COG0085	RNA polymerase activity
ATC04_RS06070	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ATC04_RS06080	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ATC04_RS06085	COG0049	tRNA binding
ATC04_RS06090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ATC04_RS06095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ATC04_RS06105	COG0051	transcription antitermination factor activity, RNA binding
ATC04_RS06110	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ATC04_RS06115	COG0088	Forms part of the polypeptide exit tunnel
ATC04_RS06120	COG0089	rRNA binding
ATC04_RS06125	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ATC04_RS06130	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ATC04_RS06135	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ATC04_RS06140	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ATC04_RS06145	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ATC04_RS06155	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ATC04_RS06180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ATC04_RS06185	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ATC04_RS06190	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ATC04_RS06195	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ATC04_RS06200	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ATC04_RS06205	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ATC04_RS06210	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ATC04_RS06215	COG1841	ribosomal large subunit assembly
ATC04_RS06220	COG0200	Binds to the 23S rRNA
ATC04_RS06230	COG0563	adenylate kinase activity
ATC04_RS06240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ATC04_RS06245	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ATC04_RS06250	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ATC04_RS06255	COG0202	RNA polymerase activity
ATC04_RS06260	COG0203	ribosomal protein L17
ATC04_RS06270	COG0101	tRNA pseudouridine synthase activity
ATC04_RS06275	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ATC04_RS06280	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ATC04_RS06285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ATC04_RS06290	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ATC04_RS06315	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ATC04_RS06315	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ATC04_RS06320	COG0736	holo-[acyl-carrier-protein] synthase activity
ATC04_RS06325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ATC04_RS06330	COG1072	(Pantothenic acid kinase))
ATC04_RS06335	COG1970	mechanosensitive ion channel activity
ATC04_RS06340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ATC04_RS06345	COG0802	atpase or kinase
ATC04_RS06350	COG1214	PFAM Peptidase M22, glycoprotease
ATC04_RS06350	COG0456	acetyltransferase
ATC04_RS06355	COG0456	acetyltransferase
ATC04_RS06360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ATC04_RS06365	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ATC04_RS06380	COG0833	amino acid
ATC04_RS06385	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ATC04_RS06390	COG0459	protein refolding
ATC04_RS06435	COG0516	GMP reductase activity
ATC04_RS06450	COG0519	Catalyzes the synthesis of GMP from XMP
ATC04_RS06450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ATC04_RS06470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ATC04_RS06475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ATC04_RS06485	COG1522	sequence-specific DNA binding
ATC04_RS06510	COG2326	polyphosphate kinase activity
ATC04_RS06520	COG1722	exodeoxyribonuclease VII activity
ATC04_RS06525	COG1570	exodeoxyribonuclease VII activity
ATC04_RS06530	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ATC04_RS06535	COG0012	GTP binding
ATC04_RS06585	COG0463	Glycosyl transferase, family 2
ATC04_RS06610	COG4044	May play a role in the intracellular transport of hydrophobic ligands
ATC04_RS06670	COG0798	PFAM Bile acid sodium symporter
ATC04_RS06675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ATC04_RS06715	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_RS06720	COG2267	carboxylic ester hydrolase activity
ATC04_RS06740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ATC04_RS06740	COG2022	thiamine diphosphate biosynthetic process
ATC04_RS06750	COG2022	thiamine diphosphate biosynthetic process
ATC04_RS06765	COG1217	gtp-binding protein TYPA
ATC04_RS06780	COG1819	glycosyl
ATC04_RS06810	COG2171	N-acyltransferase activity
ATC04_RS06815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ATC04_RS06825	COG0765	amino acid transport
ATC04_RS06830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ATC04_RS06835	COG1126	abc transporter atp-binding protein
ATC04_RS06840	COG1611	Belongs to the LOG family
ATC04_RS06855	COG1595	DNA-templated transcription, initiation
ATC04_RS06865	COG0489	protein tyrosine kinase activity
ATC04_RS06865	COG2151	metal-sulfur cluster biosynthetic enzyme
ATC04_RS06875	COG2239	Acts as a magnesium transporter
ATC04_RS06885	COG0006	proline dipeptidase activity
ATC04_RS06895	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ATC04_RS06905	COG0557	exoribonuclease II activity
ATC04_RS06915	COG1309	transcriptional regulator
ATC04_RS06920	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ATC04_RS06925	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ATC04_RS06930	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ATC04_RS06935	COG3253	May function as heme-dependent peroxidase
ATC04_RS06940	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ATC04_RS06945	COG0181	hydroxymethylbilane synthase activity
ATC04_RS06955	COG0113	porphobilinogen synthase activity
ATC04_RS06960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ATC04_RS06965	COG0531	amino acid
ATC04_RS06970	COG1464	Belongs to the NlpA lipoprotein family
ATC04_RS06975	COG2011	ABC-type metal ion transport system permease component
ATC04_RS06980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ATC04_RS07030	COG3480	Lon protease (S16) C-terminal proteolytic domain
ATC04_RS07035	COG1615	UPF0182 protein
ATC04_RS07065	COG1842	Phage shock protein A
ATC04_RS07075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ATC04_RS07085	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ATC04_RS07100	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ATC04_RS07120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ATC04_RS07135	COG0482	sulfurtransferase activity
ATC04_RS07165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ATC04_RS07180	COG4533	DNA binding
ATC04_RS07185	COG0601	transmembrane transport
ATC04_RS07190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ATC04_RS07195	COG4172	Belongs to the ABC transporter superfamily
ATC04_RS07210	COG0745	RESPONSE REGULATOR receiver
ATC04_RS07215	COG5002	protein histidine kinase activity
ATC04_RS07220	COG5401	PFAM Sporulation and spore germination
ATC04_RS07225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ATC04_RS07230	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ATC04_RS07235	COG3214	Protein conserved in bacteria
ATC04_RS07240	COG0653	protein targeting
ATC04_RS07270	COG2902	Dehydrogenase
ATC04_RS07280	COG1388	LysM domain
ATC04_RS07280	COG3942	CHAP domain
ATC04_RS07290	COG0142	geranyltranstransferase activity
ATC04_RS07295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ATC04_RS07305	COG2001	Belongs to the MraZ family
ATC04_RS07310	COG0275	rRNA processing
ATC04_RS07335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ATC04_RS07340	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ATC04_RS07345	COG0772	Belongs to the SEDS family
ATC04_RS07350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ATC04_RS07355	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ATC04_RS07360	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ATC04_RS07365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ATC04_RS07375	COG1799	cell septum assembly
ATC04_RS07390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ATC04_RS07400	COG0587	DNA-directed DNA polymerase activity
ATC04_RS07405	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ATC04_RS07410	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ATC04_RS07425	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ATC04_RS07430	COG0174	glutamine synthetase
ATC04_RS07435	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ATC04_RS07445	COG0590	tRNA wobble adenosine to inosine editing
ATC04_RS07455	COG0174	glutamine synthetase
ATC04_RS07470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ATC04_RS07475	COG0321	lipoyl(octanoyl) transferase activity
ATC04_RS07490	COG0508	dehydrogenase complex catalyzes the overall conversion of
ATC04_RS07495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ATC04_RS07500	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ATC04_RS07520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ATC04_RS07525	COG0187	DNA topoisomerase II activity
ATC04_RS07540	COG1271	oxidase subunit
ATC04_RS07545	COG1294	oxidase, subunit
ATC04_RS07550	COG4988	ABC transporter
ATC04_RS07555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ATC04_RS07560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ATC04_RS07560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ATC04_RS07590	COG0756	dUTP diphosphatase activity
ATC04_RS07615	COG0569	domain protein
ATC04_RS07620	COG0531	amino acid
ATC04_RS07630	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ATC04_RS07675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ATC04_RS07680	COG3557	Belongs to the UPF0374 family
ATC04_RS07705	COG0137	argininosuccinate synthase activity
ATC04_RS07710	COG0667	Aldo Keto reductase
ATC04_RS07725	COG1250	3-hydroxyacyl-CoA dehydrogenase
ATC04_RS07725	COG1024	Enoyl-CoA hydratase
ATC04_RS07730	COG0183	Belongs to the thiolase family
ATC04_RS07760	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ATC04_RS07770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ATC04_RS07790	COG3135	benzoate transporter
ATC04_RS07840	COG0242	peptide deformylase activity
ATC04_RS07845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ATC04_RS07855	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ATC04_RS07875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ATC04_RS07875	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ATC04_RS07880	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ATC04_RS07885	COG0140	phosphoribosyl-ATP diphosphatase activity
ATC04_RS07890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ATC04_RS07895	COG0107	imidazoleglycerol-phosphate synthase activity
ATC04_RS07905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ATC04_RS07925	COG0134	indole-3-glycerol-phosphate synthase activity
ATC04_RS07930	COG0133	tryptophan synthase activity
ATC04_RS07935	COG0159	tryptophan synthase activity
ATC04_RS07940	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ATC04_RS07945	COG0069	glutamate synthase activity
ATC04_RS07945	COG0070	glutamate synthase
ATC04_RS07945	COG0067	glutamate synthase
ATC04_RS07955	COG0469	pyruvate kinase activity
ATC04_RS07985	COG2050	protein possibly involved in aromatic compounds catabolism
ATC04_RS07995	COG4552	Acetyltransferase involved in intracellular survival and related
ATC04_RS08005	COG0539	negative regulation of cytoplasmic translation
ATC04_RS08030	COG1739	Uncharacterized protein family UPF0029
ATC04_RS08040	COG0237	dephospho-CoA kinase activity
ATC04_RS08065	COG0556	nucleotide-excision repair
ATC04_RS08075	COG1846	Transcriptional regulator
ATC04_RS08130	COG4106	trans-aconitate 2-methyltransferase activity
ATC04_RS08150	COG3220	belongs to the UPF0276 family
ATC04_RS08175	COG0546	phosphoglycolate phosphatase activity
ATC04_RS08185	COG0322	excinuclease ABC activity
ATC04_RS08190	COG1660	Displays ATPase and GTPase activities
ATC04_RS08195	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ATC04_RS08200	COG1481	regulation of sporulation
ATC04_RS08215	COG0126	phosphoglycerate kinase activity
ATC04_RS08220	COG0149	triose-phosphate isomerase activity
ATC04_RS08225	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ATC04_RS08235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ATC04_RS08260	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ATC04_RS08270	COG0109	protoheme IX farnesyltransferase activity
ATC04_RS08295	COG1131	(ABC) transporter
ATC04_RS08315	COG0396	ATPase activity
ATC04_RS08320	COG2151	metal-sulfur cluster biosynthetic enzyme
ATC04_RS08325	COG2151	metal-sulfur cluster biosynthetic enzyme
ATC04_RS08335	COG0318	PFAM AMP-dependent synthetase and ligase
ATC04_RS08340	COG1268	BioY protein
ATC04_RS08345	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ATC04_RS08350	COG1122	ATPase activity
ATC04_RS08355	COG1280	lysine exporter protein (LysE YggA)
ATC04_RS08360	COG1522	sequence-specific DNA binding
ATC04_RS08365	COG0738	Major facilitator superfamily
ATC04_RS08385	COG0629	single-stranded DNA binding
ATC04_RS08405	COG1946	Acyl-CoA thioesterase
ATC04_RS08430	COG0698	ribose 5-phosphate isomerase
ATC04_RS08455	COG0544	peptidyl-prolyl cis-trans isomerase activity
ATC04_RS08465	COG0740	serine-type endopeptidase activity
ATC04_RS08470	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ATC04_RS08475	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ATC04_RS08485	COG0525	valine-tRNA ligase activity
ATC04_RS08510	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ATC04_RS08515	COG0175	sulfate reduction
ATC04_RS08555	COG2176	DNA-directed DNA polymerase activity
ATC04_RS08570	COG2409	Drug exporters of the RND superfamily
ATC04_RS08575	COG2197	response regulator
ATC04_RS08580	COG4585	Histidine kinase
ATC04_RS08595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ATC04_RS08600	COG0285	dihydrofolate synthase activity
ATC04_RS08610	COG0105	UTP biosynthetic process
ATC04_RS08645	COG1530	ribonuclease E activity
ATC04_RS08650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ATC04_RS08655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ATC04_RS08660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ATC04_RS08665	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ATC04_RS08670	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ATC04_RS08680	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ATC04_RS08690	COG0799	negative regulation of ribosome biogenesis
ATC04_RS08725	COG0598	Magnesium transport protein CorA
ATC04_RS08745	COG1113	amino acid transport
ATC04_RS08750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ATC04_RS08760	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_RS08775	COG0583	DNA-binding transcription factor activity
ATC04_RS08780	COG1053	succinate dehydrogenase
ATC04_RS08790	COG0488	(ABC) transporter
ATC04_RS08810	COG1250	3-hydroxyacyl-CoA dehydrogenase
ATC04_RS08825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ATC04_RS08835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ATC04_RS08840	COG0028	Belongs to the TPP enzyme family
ATC04_RS08845	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ATC04_RS08855	COG1780	Probably involved in ribonucleotide reductase function
ATC04_RS08860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ATC04_RS08865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ATC04_RS08870	COG0574	Belongs to the PEP-utilizing enzyme family
ATC04_RS08870	COG3848	Pyruvate phosphate dikinase
ATC04_RS08880	COG2814	Major facilitator Superfamily
ATC04_RS08920	COG2135	peptidase activity
ATC04_RS08930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ATC04_RS08945	COG0477	Major facilitator Superfamily
ATC04_RS08965	COG0587	DNA-directed DNA polymerase activity
ATC04_RS08995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ATC04_RS09005	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ATC04_RS09010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ATC04_RS09015	COG0156	8-amino-7-oxononanoate synthase activity
ATC04_RS09025	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ATC04_RS09035	COG1131	(ABC) transporter
ATC04_RS09045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ATC04_RS09050	COG1349	DNA-binding transcription factor activity
ATC04_RS09060	COG0395	ABC-type sugar transport system, permease component
ATC04_RS09065	COG1653	transport
ATC04_RS09070	COG0584	glycerophosphoryl diester phosphodiesterase
ATC04_RS09075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ATC04_RS09090	COG0456	acetyltransferase
ATC04_RS09095	COG0339	signal peptide processing
ATC04_RS09105	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ATC04_RS09110	COG0217	transcriptional regulatory protein
ATC04_RS09115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ATC04_RS09120	COG0632	four-way junction helicase activity
ATC04_RS09125	COG2255	four-way junction helicase activity
ATC04_RS09130	COG1862	Preprotein translocase
ATC04_RS09140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ATC04_RS09145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ATC04_RS09155	COG1196	nuclear chromosome segregation
ATC04_RS09160	COG0124	histidyl-tRNA synthetase
ATC04_RS09165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ATC04_RS09180	COG1490	D-aminoacyl-tRNA deacylase activity
ATC04_RS09190	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ATC04_RS09205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ATC04_RS09210	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ATC04_RS09220	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ATC04_RS09225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ATC04_RS09230	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ATC04_RS09235	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ATC04_RS09245	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ATC04_RS09250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ATC04_RS09255	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ATC04_RS09260	COG0540	Belongs to the ATCase OTCase family
ATC04_RS09265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ATC04_RS09275	COG0505	Belongs to the CarA family
ATC04_RS09280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ATC04_RS09285	COG0284	orotidine-5'-phosphate decarboxylase activity
ATC04_RS09295	COG0194	GDP metabolic process
ATC04_RS09300	COG1758	RNA polymerase activity
ATC04_RS09310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ATC04_RS09335	COG2390	Transcriptional regulator
ATC04_RS09345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ATC04_RS09350	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ATC04_RS09365	COG0495	leucyl-tRNA aminoacylation
ATC04_RS09370	COG1307	EDD domain protein, DegV family
ATC04_RS09380	COG2333	competence protein COMEC
ATC04_RS09380	COG0658	competence protein
ATC04_RS09390	COG0268	Binds directly to 16S ribosomal RNA
ATC04_RS09400	COG0481	GTPase activity
ATC04_RS09420	COG1420	regulation of RNA biosynthetic process
ATC04_RS09425	COG0484	heat shock protein binding
ATC04_RS09430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ATC04_RS09445	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ATC04_RS09455	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ATC04_RS09465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ATC04_RS09470	COG1381	Involved in DNA repair and RecF pathway recombination
ATC04_RS09475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ATC04_RS09480	COG2267	carboxylic ester hydrolase activity
ATC04_RS09485	COG0167	dihydroorotate dehydrogenase activity
ATC04_RS09505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ATC04_RS09510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ATC04_RS09520	COG2188	Transcriptional regulator
ATC04_RS09530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ATC04_RS09535	COG0723	plastoquinol--plastocyanin reductase activity
ATC04_RS09540	COG2010	Cytochrome c
ATC04_RS09545	COG1845	cytochrome c oxidase, subunit III
ATC04_RS09550	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ATC04_RS09580	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ATC04_RS09605	COG2226	methyltransferase
ATC04_RS09625	COG1216	Glycosyl transferase, family 2
ATC04_RS09640	COG0805	protein transport
ATC04_RS09645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ATC04_RS09665	COG0545	Peptidyl-prolyl cis-trans isomerase
ATC04_RS09670	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ATC04_RS09680	COG4122	O-methyltransferase activity
ATC04_RS09685	COG1222	aaa ATPase
ATC04_RS09695	COG1994	Peptidase M50
ATC04_RS09695	COG0517	IMP dehydrogenase activity
ATC04_RS09700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ATC04_RS09710	COG0215	cysteine-tRNA ligase activity
ATC04_RS09715	COG1968	undecaprenyl-diphosphatase activity
ATC04_RS09735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ATC04_RS09745	COG2205	protein histidine kinase activity
ATC04_RS09750	COG0745	RESPONSE REGULATOR receiver
ATC04_RS09755	COG1914	H( )-stimulated, divalent metal cation uptake system
ATC04_RS09765	COG1053	succinate dehydrogenase
ATC04_RS09765	COG3976	FMN-binding domain protein
ATC04_RS09780	COG0438	transferase activity, transferring glycosyl groups
ATC04_RS09790	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_RS09860	COG0095	Lipoate-protein ligase
ATC04_RS09865	COG0604	alcohol dehydrogenase
ATC04_RS09870	COG0254	rRNA binding
ATC04_RS09940	COG1119	ATPase activity
ATC04_RS09970	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_RS09975	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_RS10000	COG0488	(ABC) transporter
ATC04_RS10050	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ATC04_RS10065	COG1476	TRANSCRIPTIONal
ATC04_RS10070	COG0604	alcohol dehydrogenase
ATC04_RS10070	COG3321	synthase
ATC04_RS10085	COG1960	acyl-CoA dehydrogenase activity
ATC04_RS10090	COG0242	peptide deformylase activity
ATC04_RS10135	COG3022	response to hydroperoxide
ATC04_RS10145	COG0346	lactoylglutathione lyase activity
ATC04_RS10150	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ATC04_RS10155	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ATC04_RS10165	COG1045	serine acetyltransferase
ATC04_RS10175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ATC04_RS10195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ATC04_RS10200	COG2130	NADP-dependent
ATC04_RS10220	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ATC04_RS10230	COG2610	gluconate transmembrane transporter activity
ATC04_RS10235	COG3265	gluconokinase activity
ATC04_RS10240	COG2261	transglycosylase associated protein
ATC04_RS10250	COG1272	protein, Hemolysin III
ATC04_RS10255	COG3237	CsbD-like
ATC04_RS10285	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ATC04_RS10300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ATC04_RS10325	COG4974	Belongs to the 'phage' integrase family
ATC04_RS10340	COG0792	nuclease activity
ATC04_RS10350	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ATC04_RS10355	COG0681	Belongs to the peptidase S26 family
ATC04_RS10370	COG0681	Belongs to the peptidase S26 family
ATC04_RS10375	COG0335	large ribosomal subunit rRNA binding
ATC04_RS10380	COG0336	Belongs to the RNA methyltransferase TrmD family
ATC04_RS10385	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ATC04_RS10390	COG1837	Belongs to the UPF0109 family
ATC04_RS10395	COG0228	four-way junction DNA binding
ATC04_RS10400	COG1280	lysine exporter protein (LysE YggA)
ATC04_RS10420	COG0672	)-iron permease
ATC04_RS10430	COG2837	iron assimilation
ATC04_RS10435	COG0183	Belongs to the thiolase family
ATC04_RS10440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ATC04_RS10450	COG2514	catechol 2,3-dioxygenase activity
ATC04_RS10455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ATC04_RS10460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ATC04_RS10480	COG0741	lytic transglycosylase activity
ATC04_RS10480	COG0739	heme binding
ATC04_RS10480	COG1196	nuclear chromosome segregation
ATC04_RS10500	COG2094	Belongs to the DNA glycosylase MPG family
ATC04_RS10510	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ATC04_RS10510	COG2755	lipolytic protein G-D-S-L family
ATC04_RS10540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ATC04_RS10550	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ATC04_RS10570	COG1484	DNA-dependent DNA replication
ATC04_RS10585	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ATC04_RS10590	COG0438	transferase activity, transferring glycosyl groups
ATC04_RS10605	COG1215	transferase activity, transferring glycosyl groups
ATC04_RS10620	COG1316	TRANSCRIPTIONal
ATC04_RS10625	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ATC04_RS10630	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ATC04_RS10645	COG0742	ribosomal rna small subunit methyltransferase
ATC04_RS10655	COG1461	Dihydroxyacetone kinase
ATC04_RS10660	COG1316	TRANSCRIPTIONal
ATC04_RS10670	COG1181	Belongs to the D-alanine--D-alanine ligase family
ATC04_RS10675	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ATC04_RS10685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ATC04_RS10690	COG0066	3-isopropylmalate dehydratase activity
ATC04_RS10695	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ATC04_RS10705	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ATC04_RS10715	COG1162	GTPase activity
ATC04_RS10735	COG0546	phosphoglycolate phosphatase activity
ATC04_RS10740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ATC04_RS10745	COG0179	Fumarylacetoacetate (FAA) hydrolase
ATC04_RS10750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ATC04_RS10755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ATC04_RS10760	COG0473	3-isopropylmalate dehydrogenase activity
ATC04_RS10765	COG4585	Histidine kinase
ATC04_RS10770	COG2197	response regulator
ATC04_RS10780	COG1432	Conserved Protein
ATC04_RS10810	COG2801	Transposase and inactivated derivatives
ATC04_RS10825	COG2801	Transposase and inactivated derivatives
ATC04_RS10825	COG3415	Transposase
ATC04_RS10835	COG0438	transferase activity, transferring glycosyl groups
ATC04_RS10845	COG0489	protein tyrosine kinase activity
ATC04_RS10850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ATC04_RS10860	COG0438	transferase activity, transferring glycosyl groups
ATC04_RS10900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ATC04_RS10905	COG2197	response regulator
ATC04_RS10970	COG2244	polysaccharide biosynthetic process
ATC04_RS10975	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ATC04_RS10985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ATC04_RS10990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ATC04_RS11020	COG1088	dTDP-glucose 4,6-dehydratase activity
ATC04_RS11025	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ATC04_RS11040	COG2226	methyltransferase
ATC04_RS11045	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ATC04_RS11050	COG0440	acetolactate synthase activity
ATC04_RS11055	COG0028	Belongs to the TPP enzyme family
ATC04_RS11060	COG0129	dihydroxy-acid dehydratase activity
ATC04_RS11070	COG1215	transferase activity, transferring glycosyl groups
ATC04_RS11095	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ATC04_RS11100	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ATC04_RS11125	COG0142	geranyltranstransferase activity
ATC04_RS11140	COG0702	epimerase
ATC04_RS11145	COG1846	Transcriptional regulator
ATC04_RS11185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ATC04_RS11195	COG0579	oxidoreductase
ATC04_RS11210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ATC04_RS11230	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ATC04_RS11240	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ATC04_RS11245	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ATC04_RS11260	COG1338	Plays a role in the flagellum-specific transport system
ATC04_RS11285	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ATC04_RS11300	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ATC04_RS11310	COG0791	NLP P60 protein
ATC04_RS11320	COG1157	protein secretion by the type III secretion system
ATC04_RS11335	COG1766	The M ring may be actively involved in energy transduction
ATC04_RS11350	COG1815	bacterial-type flagellum-dependent cell motility
ATC04_RS11365	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ATC04_RS11370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ATC04_RS11385	COG1256	bacterial-type flagellum assembly
ATC04_RS11390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ATC04_RS11395	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ATC04_RS11405	COG1846	Transcriptional regulator
ATC04_RS11440	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ATC04_RS11445	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ATC04_RS11470	COG0129	dihydroxy-acid dehydratase activity
ATC04_RS11490	COG1802	Transcriptional regulator
ATC04_RS11495	COG1012	belongs to the aldehyde dehydrogenase family
ATC04_RS11510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ATC04_RS11520	COG0488	(ABC) transporter
ATC04_RS11535	COG0477	Major facilitator Superfamily
ATC04_RS11550	COG3833	ABC-type maltose transport systems, permease component
ATC04_RS11555	COG1175	transmembrane transport
ATC04_RS11565	COG0366	Alpha amylase catalytic
ATC04_RS11570	COG1609	Transcriptional regulator
ATC04_RS11590	COG0419	ATPase involved in DNA repair
ATC04_RS11595	COG0420	3'-5' exonuclease activity
ATC04_RS11610	COG2176	DNA-directed DNA polymerase activity
ATC04_RS11620	COG1131	(ABC) transporter
ATC04_RS11645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ATC04_RS11650	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ATC04_RS11665	COG0302	gtp cyclohydrolase
ATC04_RS11680	COG1234	tRNA 3'-trailer cleavage
ATC04_RS11685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ATC04_RS11695	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ATC04_RS11700	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ATC04_RS11705	COG1335	isochorismatase
ATC04_RS11720	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ATC04_RS11720	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ATC04_RS11770	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
ATC04_RS11785	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ATC04_RS11790	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ATC04_RS11795	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ATC04_RS11800	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ATC04_RS11805	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ATC04_RS11810	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ATC04_RS11815	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ATC04_RS11820	COG0356	it plays a direct role in the translocation of protons across the membrane
ATC04_RS11830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ATC04_RS11835	COG0009	L-threonylcarbamoyladenylate synthase
ATC04_RS11845	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ATC04_RS11855	COG0083	homoserine kinase activity
ATC04_RS11860	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ATC04_RS11865	COG0460	homoserine dehydrogenase
ATC04_RS11870	COG0019	diaminopimelate decarboxylase activity
ATC04_RS11875	COG0018	arginyl-trna synthetase
ATC04_RS11885	COG1116	anion transmembrane transporter activity
ATC04_RS11885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ATC04_RS11900	COG1643	Atp-dependent helicase
ATC04_RS11905	COG0537	adenosine 5'-monophosphoramidase activity
ATC04_RS11915	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ATC04_RS11940	COG1121	(ABC) transporter
ATC04_RS11945	COG1253	flavin adenine dinucleotide binding
ATC04_RS11950	COG1253	flavin adenine dinucleotide binding
ATC04_RS11955	COG0508	dehydrogenase complex catalyzes the overall conversion of
ATC04_RS11955	COG0567	Dehydrogenase, E1 component
ATC04_RS11970	COG1595	DNA-templated transcription, initiation
ATC04_RS11975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ATC04_RS11985	COG0483	inositol monophosphate 1-phosphatase activity
ATC04_RS11990	COG1321	iron dependent repressor
ATC04_RS11990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ATC04_RS11995	COG0589	response to stress
ATC04_RS12000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ATC04_RS12005	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ATC04_RS12020	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ATC04_RS12025	COG0739	heme binding
ATC04_RS12025	COG1196	nuclear chromosome segregation
ATC04_RS12025	COG0741	lytic transglycosylase activity
ATC04_RS12030	COG2177	Part of the ABC transporter FtsEX involved in
ATC04_RS12035	COG2884	Cell division ATP-binding protein ftsE
ATC04_RS12040	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ATC04_RS12140	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ATC04_RS12160	COG0582	viral genome integration into host DNA
ATC04_RS12195	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ATC04_RS12215	COG1022	Amp-dependent synthetase and ligase
ATC04_RS12225	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ATC04_RS12230	COG1192	Involved in chromosome partitioning
ATC04_RS12250	COG1716	ATPase activity
ATC04_RS12255	COG3189	MarR family transcriptional regulator
ATC04_RS12265	COG0488	(ABC) transporter
ATC04_RS12275	COG0384	phenazine biosynthesis protein PhzF
ATC04_RS12285	COG1160	GTP binding
ATC04_RS12290	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ATC04_RS12305	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ATC04_RS12325	COG1301	dicarboxylic acid transport
ATC04_RS12330	COG3290	protein histidine kinase activity
ATC04_RS12355	COG2079	MmgE PrpD family protein
ATC04_RS12360	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ATC04_RS12375	COG3655	Transcriptional regulator
ATC04_RS12380	COG0494	nUDIX hydrolase
ATC04_RS12385	COG4974	Belongs to the 'phage' integrase family
ATC04_RS12390	COG0494	nUDIX hydrolase
ATC04_RS12395	COG0504	CTP synthase activity
ATC04_RS12400	COG0497	DNA recombination
ATC04_RS12405	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ATC04_RS12420	COG0647	UMP catabolic process
ATC04_RS12450	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ATC04_RS12460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ATC04_RS12470	COG0165	Argininosuccinate lyase
ATC04_RS12480	COG1438	arginine binding
ATC04_RS12485	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ATC04_RS12490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ATC04_RS12495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ATC04_RS12500	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ATC04_RS12505	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ATC04_RS12540	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ATC04_RS12550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ATC04_RS12555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ATC04_RS12555	COG0072	phenylalanine-tRNA ligase activity
ATC04_RS12560	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ATC04_RS12570	COG0494	nUDIX hydrolase
ATC04_RS12575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ATC04_RS12580	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ATC04_RS12585	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ATC04_RS12590	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ATC04_RS12610	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ATC04_RS12615	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ATC04_RS12620	COG0131	Imidazoleglycerol-phosphate dehydratase
ATC04_RS12625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ATC04_RS12635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ATC04_RS12645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ATC04_RS12650	COG2813	Specifically methylates the guanine in position
ATC04_RS12655	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ATC04_RS12660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ATC04_RS12665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ATC04_RS12675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ATC04_RS12690	COG1546	Belongs to the CinA family
ATC04_RS12690	COG1058	Belongs to the CinA family
ATC04_RS12700	COG1674	ftsk spoiiie
ATC04_RS12710	COG1174	glycine betaine transport
ATC04_RS12715	COG1174	glycine betaine transport
ATC04_RS12720	COG1125	glycine betaine transport
ATC04_RS12720	COG0517	IMP dehydrogenase activity
ATC04_RS12725	COG2314	TM2 domain
ATC04_RS12745	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ATC04_RS12750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ATC04_RS12765	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ATC04_RS12780	COG0612	Peptidase, M16
ATC04_RS12785	COG2235	arginine
ATC04_RS12795	COG1053	succinate dehydrogenase
ATC04_RS12800	COG1063	alcohol dehydrogenase
ATC04_RS12810	COG1053	succinate dehydrogenase
ATC04_RS12825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ATC04_RS12830	COG0477	Major facilitator Superfamily
ATC04_RS12835	COG0583	DNA-binding transcription factor activity
ATC04_RS12840	COG1053	succinate dehydrogenase
ATC04_RS12845	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ATC04_RS12900	COG1185	polyribonucleotide nucleotidyltransferase activity
ATC04_RS12910	COG2807	transmembrane transport
ATC04_RS12920	COG1414	Transcriptional regulator
ATC04_RS12930	COG2124	cytochrome p450
ATC04_RS12950	COG1012	belongs to the aldehyde dehydrogenase family
ATC04_RS12960	COG4565	transcriptional regulatory protein
ATC04_RS12965	COG3290	protein histidine kinase activity
ATC04_RS12985	COG0589	response to stress
ATC04_RS12995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ATC04_RS13000	COG0318	PFAM AMP-dependent synthetase and ligase
ATC04_RS13005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ATC04_RS13020	COG1619	proteins homologs of microcin C7 resistance protein MccF
ATC04_RS13040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ATC04_RS13045	COG4106	trans-aconitate 2-methyltransferase activity
ATC04_RS13050	COG0196	riboflavin kinase activity
ATC04_RS13065	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ATC04_RS13080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ATC04_RS13090	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ATC04_RS13110	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ATC04_RS13115	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ATC04_RS13120	COG0481	GTPase activity
ATC04_RS13120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ATC04_RS13130	COG0779	Required for maturation of 30S ribosomal subunits
ATC04_RS13155	COG4585	Histidine kinase
ATC04_RS13160	COG2197	response regulator
ATC04_RS13170	COG0442	prolyl-tRNA aminoacylation
ATC04_RS13200	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ATC04_RS13220	COG0750	zinc metalloprotease
ATC04_RS13225	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ATC04_RS13230	COG1960	acyl-CoA dehydrogenase activity
ATC04_RS13250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ATC04_RS13270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ATC04_RS13275	COG0601	transmembrane transport
ATC04_RS13280	COG0747	negative chemotaxis
ATC04_RS13285	COG0508	dehydrogenase complex catalyzes the overall conversion of
ATC04_RS13290	COG0022	dehydrogenase e1 component
ATC04_RS13305	COG1215	transferase activity, transferring glycosyl groups
ATC04_RS13310	COG1181	Belongs to the D-alanine--D-alanine ligase family
ATC04_RS13315	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ATC04_RS13320	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ATC04_RS13330	COG3275	phosphorelay sensor kinase activity
ATC04_RS13335	COG3279	Response regulator of the LytR AlgR family
ATC04_RS13345	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ATC04_RS13355	COG0575	Belongs to the CDS family
ATC04_RS13360	COG0233	cytoplasmic translational termination
ATC04_RS13365	COG0528	UMP kinase activity
ATC04_RS13370	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ATC04_RS13375	COG0052	Belongs to the universal ribosomal protein uS2 family
ATC04_RS13390	COG0438	transferase activity, transferring glycosyl groups
ATC04_RS13410	COG0438	transferase activity, transferring glycosyl groups
ATC04_RS13425	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ATC04_RS13440	COG1695	Transcriptional regulator
ATC04_RS13475	COG0358	DNA primase activity
ATC04_RS13525	COG0423	glycine-tRNA ligase activity
ATC04_RS13530	COG2501	S4 domain
ATC04_RS13545	COG2755	lipolytic protein G-D-S-L family
ATC04_RS13550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ATC04_RS13555	COG2873	o-acetylhomoserine
ATC04_RS13585	COG1349	DNA-binding transcription factor activity
ATC04_RS13600	COG1175	transmembrane transport
ATC04_RS13615	COG1105	Belongs to the carbohydrate kinase PfkB family
ATC04_RS13630	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ATC04_RS13635	COG1228	amidohydrolase
ATC04_RS13640	COG1228	amidohydrolase
ATC04_RS13645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ATC04_RS13650	COG3314	Sporulation integral membrane protein YlbJ
ATC04_RS13655	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ATC04_RS13670	COG0395	ABC-type sugar transport system, permease component
ATC04_RS13675	COG1175	transmembrane transport
ATC04_RS13680	COG1653	transport
ATC04_RS13695	COG1063	alcohol dehydrogenase
ATC04_RS13705	COG0477	Major facilitator Superfamily
ATC04_RS13715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ATC04_RS13725	COG4608	Belongs to the ABC transporter superfamily
ATC04_RS13730	COG0444	Belongs to the ABC transporter superfamily
ATC04_RS13740	COG0601	transmembrane transport
ATC04_RS13745	COG0747	negative chemotaxis
ATC04_RS13765	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ATC04_RS13770	COG0154	amidase activity
ATC04_RS13775	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ATC04_RS13805	COG1472	Belongs to the glycosyl hydrolase 3 family
ATC04_RS13810	COG0363	glucosamine-6-phosphate deaminase activity
ATC04_RS13835	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ATC04_RS13860	COG3347	Dehydrogenase
ATC04_RS13860	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_RS13865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ATC04_RS13880	COG2814	Major facilitator Superfamily
ATC04_RS13890	COG0346	lactoylglutathione lyase activity
ATC04_RS13895	COG0640	Transcriptional regulator
ATC04_RS13900	COG1823	symporter activity
ATC04_RS13915	COG2409	Drug exporters of the RND superfamily
ATC04_RS13920	COG0424	maF-like protein
ATC04_RS13935	COG0754	glutathionylspermidine amidase activity
ATC04_RS13945	COG4770	biotin carboxylase activity
ATC04_RS13970	COG0477	Major facilitator Superfamily
ATC04_RS13985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ATC04_RS13990	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ATC04_RS14020	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ATC04_RS14025	COG0822	iron-sulfur transferase activity
ATC04_RS14040	COG0193	aminoacyl-tRNA hydrolase activity
ATC04_RS14045	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ATC04_RS14060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ATC04_RS14070	COG0488	(ABC) transporter
ATC04_RS14075	COG4335	DNA alkylation repair
ATC04_RS14110	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_RS14125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ATC04_RS14130	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ATC04_RS14135	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ATC04_RS14140	COG3583	domain protein
ATC04_RS14145	COG0084	hydrolase, TatD family'
ATC04_RS14150	COG0714	Associated with various cellular activities
ATC04_RS14175	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
ATC04_RS14235	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ATC04_RS14240	COG1316	TRANSCRIPTIONal
ATC04_RS14250	COG1494	fructose-1,6-bisphosphatase
ATC04_RS14265	COG0114	fumarate hydratase activity
ATC04_RS14290	COG0477	Major facilitator Superfamily
ATC04_RS14310	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ATC04_RS14315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ATC04_RS14320	COG1331	Highly conserved protein containing a thioredoxin domain
ATC04_RS14330	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ATC04_RS14340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ATC04_RS14345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ATC04_RS14375	COG2801	Transposase and inactivated derivatives
ATC04_RS14380	COG4974	Belongs to the 'phage' integrase family
ATC04_RS14415	COG0148	phosphopyruvate hydratase activity
ATC04_RS14430	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ATC04_RS14450	COG1079	Belongs to the binding-protein-dependent transport system permease family
ATC04_RS14455	COG4603	Belongs to the binding-protein-dependent transport system permease family
ATC04_RS14460	COG3845	ABC transporter
ATC04_RS14465	COG1744	ABC transporter substrate-binding protein PnrA-like
ATC04_RS14470	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ATC04_RS14470	COG1473	amidohydrolase
ATC04_RS14475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ATC04_RS14485	COG2009	succinate dehydrogenase
ATC04_RS14495	COG1053	succinate dehydrogenase
ATC04_RS14500	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ATC04_RS14505	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ATC04_RS14510	COG0180	Tryptophanyl-tRNA synthetase
ATC04_RS14515	COG0708	Exodeoxyribonuclease III
ATC04_RS14540	COG2197	response regulator
ATC04_RS14555	COG0477	Major facilitator Superfamily
ATC04_RS14605	COG0477	Major facilitator Superfamily
ATC04_RS14610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ATC04_RS14615	COG2072	flavoprotein involved in K transport
ATC04_RS14630	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ATC04_RS14635	COG3708	Transcriptional regulator
ATC04_RS14635	COG2207	Transcriptional regulator
ATC04_RS14655	COG2873	o-acetylhomoserine
ATC04_RS14700	COG1295	ribonuclease BN
ATC04_RS14765	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ATC04_RS14785	COG2217	Heavy metal translocating P-type atpase
ATC04_RS14800	COG2132	Multicopper oxidase
ATC04_RS14825	COG0785	Cytochrome C biogenesis protein
ATC04_RS14830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ATC04_RS14835	COG4974	Belongs to the 'phage' integrase family
ATC04_RS14850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ATC04_RS14860	COG1028	Short-chain dehydrogenase reductase Sdr
ATC04_RS14870	COG1802	Transcriptional regulator
ATC04_RS14875	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ATC04_RS14885	COG2838	Isocitrate dehydrogenase
ATC04_RS14895	COG2814	Major facilitator Superfamily
ATC04_RS14905	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ATC04_RS14910	COG1984	allophanate hydrolase subunit 2
ATC04_RS14915	COG4770	biotin carboxylase activity
ATC04_RS14945	COG4336	lyase activity
ATC04_RS14950	COG1914	H( )-stimulated, divalent metal cation uptake system
ATC04_RS14955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ATC04_RS14960	COG0138	bifunctional purine biosynthesis protein purh
ATC04_RS14970	COG0477	Major facilitator Superfamily
ATC04_RS15010	COG3971	2-oxopent-4-enoate hydratase activity
ATC04_RS15020	COG3483	tryptophan 2,3-dioxygenase activity
ATC04_RS15030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ATC04_RS15035	COG1652	LysM domain
ATC04_RS15040	COG1295	ribonuclease BN
ATC04_RS15085	COG0577	efflux transmembrane transporter activity
ATC04_RS15090	COG0577	efflux transmembrane transporter activity
ATC04_RS15090	COG1136	(ABC) transporter
ATC04_RS15105	COG0519	Catalyzes the synthesis of GMP from XMP
ATC04_RS15130	COG1250	3-hydroxyacyl-CoA dehydrogenase
ATC04_RS15135	COG1012	belongs to the aldehyde dehydrogenase family
ATC04_RS15140	COG1960	acyl-CoA dehydrogenase activity
ATC04_RS15145	COG2508	Transcriptional regulator
ATC04_RS15160	COG2814	Major facilitator Superfamily
ATC04_RS15165	COG1846	Transcriptional regulator
ATC04_RS15180	COG0028	Belongs to the TPP enzyme family
ATC04_RS15200	COG0531	amino acid
ATC04_RS15210	COG1396	sequence-specific DNA binding
ATC04_RS15235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ATC04_RS15250	COG0045	succinate-CoA ligase (ADP-forming) activity
ATC04_RS15290	COG0739	heme binding
ATC04_RS15295	COG1321	iron dependent repressor
ATC04_RS15320	COG0745	RESPONSE REGULATOR receiver
ATC04_RS15325	COG2205	protein histidine kinase activity
ATC04_RS15345	COG0459	protein refolding
ATC04_RS15360	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ATC04_RS15395	COG2354	Protein conserved in bacteria
ATC04_RS15420	COG3842	ATPase activity
ATC04_RS15460	COG0277	FAD linked oxidase domain protein
ATC04_RS15480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ATC04_RS15485	COG0215	cysteine-tRNA ligase activity
ATC04_RS15490	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ATC04_RS15490	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ATC04_RS15495	COG1329	Transcriptional regulator
ATC04_RS15510	COG5002	protein histidine kinase activity
ATC04_RS15525	COG0588	phosphoglycerate mutase activity
ATC04_RS15540	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ATC04_RS15670	COG4974	Belongs to the 'phage' integrase family
ATC04_RS15675	COG0656	L-ascorbic acid biosynthetic process
ATC04_RS15715	COG1966	Carbon starvation protein
ATC04_RS15720	COG0604	alcohol dehydrogenase
ATC04_RS15735	COG1505	serine-type exopeptidase activity
ATC04_RS15750	COG0514	ATP-dependent DNA helicase (RecQ)
ATC04_RS15765	COG1959	2 iron, 2 sulfur cluster binding
ATC04_RS15770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ATC04_RS15770	COG1017	nitric oxide dioxygenase activity
ATC04_RS15775	COG0596	Alpha beta hydrolase
ATC04_RS15775	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ATC04_RS15785	COG2814	Major facilitator Superfamily
ATC04_RS15790	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ATC04_RS15815	COG2723	6-phospho-beta-galactosidase activity
ATC04_RS15845	COG1511	domain protein
ATC04_RS15855	COG2274	protein secretion by the type I secretion system
ATC04_RS15875	COG0745	RESPONSE REGULATOR receiver
ATC04_RS15880	COG2205	protein histidine kinase activity
ATC04_RS15885	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ATC04_RS15930	COG1140	nitrate reductase beta subunit
ATC04_RS15955	COG0746	molybdenum cofactor guanylyltransferase activity
ATC04_RS15980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ATC04_RS15990	COG2318	DinB family
ATC04_RS15995	COG2378	regulation of single-species biofilm formation
ATC04_RS16020	COG0315	cyclic pyranopterin monophosphate synthase activity
ATC04_RS16025	COG0521	Mo-molybdopterin cofactor biosynthetic process
ATC04_RS16025	COG0315	cyclic pyranopterin monophosphate synthase activity
ATC04_RS16030	COG0584	glycerophosphoryl diester phosphodiesterase
ATC04_RS16055	COG1414	Transcriptional regulator
ATC04_RS16060	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ATC04_RS16070	COG0183	Belongs to the thiolase family
ATC04_RS16075	COG2814	Major facilitator Superfamily
ATC04_RS16085	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
ATC04_RS16090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ATC04_RS16100	COG3485	protocatechuate 3,4-dioxygenase
ATC04_RS16105	COG3485	protocatechuate 3,4-dioxygenase
ATC04_RS16120	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ATC04_RS16145	COG1131	(ABC) transporter
ATC04_RS16160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ATC04_RS16165	COG0786	glutamate:sodium symporter activity
ATC04_RS16175	COG1414	Transcriptional regulator
ATC04_RS16180	COG0671	phosphoesterase, PA-phosphatase related
ATC04_RS16185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ATC04_RS16190	COG1201	RNA secondary structure unwinding
ATC04_RS16195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ATC04_RS16200	COG0564	pseudouridine synthase activity
ATC04_RS16215	COG2814	Major facilitator Superfamily
ATC04_RS16230	COG0343	queuine tRNA-ribosyltransferase activity
ATC04_RS16240	COG4133	protoheme IX ABC transporter activity
ATC04_RS16265	COG0351	phosphomethylpyrimidine kinase
ATC04_RS16280	COG1472	Belongs to the glycosyl hydrolase 3 family
ATC04_RS16310	COG0778	Nitroreductase
ATC04_RS16315	COG4585	Histidine kinase
ATC04_RS16325	COG2197	response regulator
ATC04_RS16330	COG0542	response to heat
ATC04_RS16370	COG1476	TRANSCRIPTIONal
ATC04_RS16395	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ATC04_RS16405	COG0406	alpha-ribazole phosphatase activity
ATC04_RS16440	COG0745	RESPONSE REGULATOR receiver
ATC04_RS16465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ATC04_RS16475	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ATC04_RS16505	COG4565	transcriptional regulatory protein
ATC04_RS16510	COG3290	protein histidine kinase activity
ATC04_RS16515	COG2851	Citrate transporter
ATC04_RS16520	COG2318	DinB family
ATC04_RS16540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ATC04_RS16550	COG3012	SEC-C Motif Domain Protein
ATC04_RS16555	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ATC04_RS16560	COG0047	phosphoribosylformylglycinamidine synthase activity
ATC04_RS16565	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ATC04_RS16580	COG2824	Alkylphosphonate utilization operon protein PhnA
ATC04_RS16590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ATC04_RS16620	COG0737	Belongs to the 5'-nucleotidase family
ATC04_RS16635	COG2315	Protein conserved in bacteria
ATC04_RS16640	COG1832	CoA-binding protein
ATC04_RS16650	COG1960	acyl-CoA dehydrogenase activity
ATC04_RS16660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ATC04_RS16665	COG0601	transmembrane transport
ATC04_RS16680	COG0702	epimerase
ATC04_RS16700	COG0405	Gamma-glutamyltransferase
ATC04_RS16730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ATC04_RS16735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ATC04_RS16740	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ATC04_RS16750	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ATC04_RS16755	COG2169	Transcriptional regulator
ATC04_RS16755	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ATC04_RS16765	COG0406	alpha-ribazole phosphatase activity
ATC04_RS16770	COG2873	o-acetylhomoserine
ATC04_RS16775	COG1832	CoA-binding protein
ATC04_RS16780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ATC04_RS16785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ATC04_RS16790	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ATC04_RS16800	COG1349	DNA-binding transcription factor activity
ATC04_RS16810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ATC04_RS16810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ATC04_RS16810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ATC04_RS16815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ATC04_RS16830	COG0726	polysaccharide deacetylase
ATC04_RS16850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ATC04_RS16855	COG0028	Belongs to the TPP enzyme family
ATC04_RS16865	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ATC04_RS16880	COG0697	spore germination
ATC04_RS16890	COG0583	DNA-binding transcription factor activity
ATC04_RS16900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ATC04_RS16915	COG0347	Belongs to the P(II) protein family
ATC04_RS16920	COG0004	ammonium transporteR
ATC04_RS16925	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ATC04_RS16945	COG1113	amino acid transport
ATC04_RS16955	COG1522	sequence-specific DNA binding
ATC04_RS16965	COG5002	protein histidine kinase activity
ATC04_RS16970	COG0745	RESPONSE REGULATOR receiver
ATC04_RS17015	COG1674	ftsk spoiiie
ATC04_RS17020	COG0515	serine threonine protein kinase
ATC04_RS17040	COG0357	Ribosomal RNA small subunit methyltransferase G
ATC04_RS17040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ATC04_RS17055	COG1131	(ABC) transporter
ATC04_RS17070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ATC04_RS17080	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ATC04_RS17100	COG1960	acyl-CoA dehydrogenase activity
ATC04_RS17115	COG1024	Enoyl-CoA hydratase
ATC04_RS17165	COG2252	PERMEase
ATC04_RS17190	COG4122	O-methyltransferase activity
ATC04_RS17290	COG0277	FAD linked oxidase domain protein
ATC04_RS17310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ATC04_RS17325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ATC04_RS17330	COG1937	Protein conserved in bacteria
ATC04_RS17345	COG0824	Thioesterase
ATC04_RS17360	COG0596	Alpha beta hydrolase
ATC04_RS17395	COG2226	methyltransferase
ATC04_RS17400	COG0488	(ABC) transporter
ATC04_RS17450	COG0306	phosphate transporter
ATC04_RS17465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ATC04_RS17480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ATC04_RS17490	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ATC04_RS17495	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ATC04_RS17505	COG1194	a g-specific adenine glycosylase
ATC04_RS17515	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ATC04_RS17540	COG5632	N-Acetylmuramoyl-L-alanine amidase
ATC04_RS17540	COG3409	Peptidoglycan-binding domain 1 protein
ATC04_RS17780	COG5632	N-Acetylmuramoyl-L-alanine amidase
ATC04_RS17780	COG3409	Peptidoglycan-binding domain 1 protein
ATC04_RS17990	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ATC04_RS18130	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ATC04_RS18130	COG0352	thiamine-phosphate diphosphorylase activity
ATC04_RS18130	COG0351	phosphomethylpyrimidine kinase