locus-tag	class	description
KG104_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KG104_RS00010	COG0592	DNA-directed DNA polymerase activity
KG104_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KG104_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KG104_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
KG104_RS00030	COG0187	DNA topoisomerase II activity
KG104_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KG104_RS00040	COG3266	domain, Protein
KG104_RS00075	COG0705	Rhomboid family
KG104_RS00085	COG3764	Sortase (surface protein transpeptidase)
KG104_RS00105	COG0515	serine threonine protein kinase
KG104_RS00110	COG0768	penicillin binding
KG104_RS00125	COG1716	ATPase activity
KG104_RS00130	COG1716	ATPase activity
KG104_RS00150	COG0346	lactoylglutathione lyase activity
KG104_RS00165	COG2610	gluconate transmembrane transporter activity
KG104_RS00170	COG3265	gluconokinase activity
KG104_RS00175	COG2186	Transcriptional regulator
KG104_RS00180	COG0783	Belongs to the Dps family
KG104_RS00190	COG0723	plastoquinol--plastocyanin reductase activity
KG104_RS00195	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS00210	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KG104_RS00230	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KG104_RS00240	COG0789	Transcriptional regulator
KG104_RS00260	COG0702	epimerase
KG104_RS00285	COG1063	alcohol dehydrogenase
KG104_RS00290	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS00295	COG1609	Transcriptional regulator
KG104_RS00325	COG0561	phosphatase activity
KG104_RS00330	COG0671	phosphoesterase, PA-phosphatase related
KG104_RS00335	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
KG104_RS00340	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KG104_RS00345	COG0584	glycerophosphoryl diester phosphodiesterase
KG104_RS00350	COG1929	Belongs to the glycerate kinase type-1 family
KG104_RS00355	COG2233	PERMEase
KG104_RS00365	COG1012	belongs to the aldehyde dehydrogenase family
KG104_RS00370	COG0033	Phosphoglucomutase
KG104_RS00375	COG3104	oligopeptide transport
KG104_RS00380	COG0154	amidase activity
KG104_RS00385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KG104_RS00405	COG1597	lipid kinase activity
KG104_RS00410	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KG104_RS00415	COG0561	phosphatase activity
KG104_RS00430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KG104_RS00435	COG2027	D-alanyl-D-alanine carboxypeptidase
KG104_RS00445	COG0037	tRNA processing
KG104_RS00455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KG104_RS00460	COG0302	gtp cyclohydrolase
KG104_RS00465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KG104_RS00470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KG104_RS00475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KG104_RS00500	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KG104_RS00505	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KG104_RS00525	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KG104_RS00530	COG3237	CsbD-like
KG104_RS00535	COG2376	Dihydroxyacetone kinase
KG104_RS00540	COG1461	Dihydroxyacetone kinase
KG104_RS00545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KG104_RS00545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KG104_RS00545	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
KG104_RS00550	COG1194	a g-specific adenine glycosylase
KG104_RS00560	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
KG104_RS00590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KG104_RS00595	COG0306	phosphate transporter
KG104_RS00650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KG104_RS00655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KG104_RS00655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KG104_RS00655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KG104_RS00660	COG1105	Belongs to the carbohydrate kinase PfkB family
KG104_RS00680	COG2733	membrane
KG104_RS00685	COG3387	PFAM Glycoside hydrolase 15-related
KG104_RS00705	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KG104_RS00710	COG0857	belongs to the CobB CobQ family
KG104_RS00710	COG0280	phosphate acetyltransferase
KG104_RS00715	COG0531	amino acid
KG104_RS00730	COG2252	PERMEase
KG104_RS00800	COG0673	inositol 2-dehydrogenase activity
KG104_RS00805	COG1879	ABC-type sugar transport system periplasmic component
KG104_RS00810	COG1129	ABC transporter
KG104_RS00815	COG1172	Belongs to the binding-protein-dependent transport system permease family
KG104_RS00825	COG1940	carbohydrate kinase activity
KG104_RS00855	COG0109	protoheme IX farnesyltransferase activity
KG104_RS00865	COG1940	carbohydrate kinase activity
KG104_RS00885	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KG104_RS00890	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KG104_RS00910	COG0191	fructose-bisphosphate aldolase activity
KG104_RS00940	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KG104_RS00945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KG104_RS00960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KG104_RS00965	COG1595	DNA-templated transcription, initiation
KG104_RS00975	COG1832	CoA-binding protein
KG104_RS00990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KG104_RS00995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KG104_RS01005	COG1116	anion transmembrane transporter activity
KG104_RS01030	COG2315	Protein conserved in bacteria
KG104_RS01045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KG104_RS01050	COG0047	phosphoribosylformylglycinamidine synthase activity
KG104_RS01055	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KG104_RS01060	COG1126	abc transporter atp-binding protein
KG104_RS01065	COG0765	amino acid transport
KG104_RS01070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KG104_RS01100	COG1846	Transcriptional regulator
KG104_RS01120	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KG104_RS01155	COG3548	integral membrane protein
KG104_RS01205	COG0028	Belongs to the TPP enzyme family
KG104_RS01225	COG4585	Histidine kinase
KG104_RS01240	COG2186	Transcriptional regulator
KG104_RS01255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KG104_RS01270	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS01275	COG1012	belongs to the aldehyde dehydrogenase family
KG104_RS01315	COG1349	DNA-binding transcription factor activity
KG104_RS01325	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KG104_RS01345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KG104_RS01350	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS01355	COG0366	Alpha amylase catalytic
KG104_RS01375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KG104_RS01380	COG1120	ATPase activity
KG104_RS01395	COG0583	DNA-binding transcription factor activity
KG104_RS01430	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KG104_RS01440	COG1396	sequence-specific DNA binding
KG104_RS01445	COG0024	Methionine aminopeptidase
KG104_RS01450	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KG104_RS01460	COG1216	Glycosyl transferase, family 2
KG104_RS01470	COG0351	phosphomethylpyrimidine kinase
KG104_RS01480	COG1309	transcriptional regulator
KG104_RS01490	COG0343	queuine tRNA-ribosyltransferase activity
KG104_RS01545	COG3486	L-lysine 6-monooxygenase (NADPH) activity
KG104_RS01550	COG0076	glutamate decarboxylase activity
KG104_RS01575	COG0564	pseudouridine synthase activity
KG104_RS01580	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KG104_RS01585	COG1201	RNA secondary structure unwinding
KG104_RS01600	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KG104_RS01625	COG2354	Protein conserved in bacteria
KG104_RS01630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KG104_RS01670	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KG104_RS01680	COG2062	phosphohistidine phosphatase, SixA
KG104_RS01685	COG1511	domain protein
KG104_RS01705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KG104_RS01720	COG4569	acetaldehyde dehydrogenase (acetylating) activity
KG104_RS01725	COG3971	2-oxopent-4-enoate hydratase activity
KG104_RS01745	COG4638	Rieske (2fe-2S)
KG104_RS01750	COG2146	nitrite reductase [NAD(P)H] activity
KG104_RS01765	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS01780	COG1414	Transcriptional regulator
KG104_RS01795	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
KG104_RS01810	COG0514	ATP-dependent DNA helicase (RecQ)
KG104_RS01830	COG0667	Aldo Keto reductase
KG104_RS01835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KG104_RS01840	COG1024	Enoyl-CoA hydratase
KG104_RS01850	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KG104_RS01855	COG0247	lactate metabolic process
KG104_RS01855	COG0277	FAD linked oxidase domain protein
KG104_RS01860	COG0179	Fumarylacetoacetate (FAA) hydrolase
KG104_RS01870	COG1505	serine-type exopeptidase activity
KG104_RS01895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KG104_RS01900	COG1064	alcohol dehydrogenase
KG104_RS01910	COG4608	Belongs to the ABC transporter superfamily
KG104_RS01915	COG0444	Belongs to the ABC transporter superfamily
KG104_RS01920	COG0747	negative chemotaxis
KG104_RS01925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KG104_RS01960	COG0183	Belongs to the thiolase family
KG104_RS02005	COG1414	Transcriptional regulator
KG104_RS02010	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS02030	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS02060	COG1966	Carbon starvation protein
KG104_RS02085	COG0656	L-ascorbic acid biosynthetic process
KG104_RS02110	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KG104_RS02115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KG104_RS02135	COG0588	phosphoglycerate mutase activity
KG104_RS02145	COG5002	protein histidine kinase activity
KG104_RS02165	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KG104_RS02170	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KG104_RS02175	COG0215	cysteine-tRNA ligase activity
KG104_RS02180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KG104_RS02195	COG0366	Alpha amylase catalytic
KG104_RS02200	COG0366	Alpha amylase catalytic
KG104_RS02205	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KG104_RS02250	COG0277	FAD linked oxidase domain protein
KG104_RS02255	COG0366	Alpha amylase catalytic
KG104_RS02265	COG3842	ATPase activity
KG104_RS02275	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KG104_RS02310	COG1940	carbohydrate kinase activity
KG104_RS02330	COG3621	Patatin-like phospholipase
KG104_RS02335	COG1252	NADH dehydrogenase
KG104_RS02340	COG1595	DNA-templated transcription, initiation
KG104_RS02365	COG1653	transport
KG104_RS02435	COG0318	PFAM AMP-dependent synthetase and ligase
KG104_RS02460	COG1609	Transcriptional regulator
KG104_RS02465	COG0366	Alpha amylase catalytic
KG104_RS02475	COG1175	transmembrane transport
KG104_RS02480	COG3833	ABC-type maltose transport systems, permease component
KG104_RS02485	COG0667	Aldo Keto reductase
KG104_RS02520	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KG104_RS02535	COG1278	Cold shock
KG104_RS02540	COG0459	protein refolding
KG104_RS02550	COG2205	protein histidine kinase activity
KG104_RS02555	COG0745	RESPONSE REGULATOR receiver
KG104_RS02575	COG1278	Cold shock
KG104_RS02595	COG1321	iron dependent repressor
KG104_RS02600	COG0739	heme binding
KG104_RS02625	COG0303	'Molybdopterin
KG104_RS02630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KG104_RS02635	COG5002	protein histidine kinase activity
KG104_RS02640	COG1132	(ABC) transporter
KG104_RS02655	COG2409	Drug exporters of the RND superfamily
KG104_RS02665	COG0483	inositol monophosphate 1-phosphatase activity
KG104_RS02675	COG0045	succinate-CoA ligase (ADP-forming) activity
KG104_RS02685	COG2814	Major facilitator Superfamily
KG104_RS02695	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KG104_RS02710	COG0656	L-ascorbic acid biosynthetic process
KG104_RS02720	COG0318	PFAM AMP-dependent synthetase and ligase
KG104_RS02730	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KG104_RS02735	COG1396	sequence-specific DNA binding
KG104_RS02750	COG0028	Belongs to the TPP enzyme family
KG104_RS02775	COG3424	synthase
KG104_RS02805	COG1053	succinate dehydrogenase
KG104_RS02815	COG3655	Transcriptional regulator
KG104_RS02830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KG104_RS02840	COG0252	asparaginase activity
KG104_RS02860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KG104_RS02865	COG2197	response regulator
KG104_RS02885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KG104_RS02890	COG0477	Major facilitator Superfamily
KG104_RS02895	COG1957	nucleoside hydrolase
KG104_RS02900	COG0477	Major facilitator Superfamily
KG104_RS02915	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KG104_RS02930	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KG104_RS02955	COG3387	PFAM Glycoside hydrolase 15-related
KG104_RS02960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KG104_RS02965	COG0778	Nitroreductase
KG104_RS02965	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
KG104_RS02970	COG1120	ATPase activity
KG104_RS02975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KG104_RS02990	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KG104_RS03000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KG104_RS03005	COG1116	anion transmembrane transporter activity
KG104_RS03010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KG104_RS03015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KG104_RS03035	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KG104_RS03040	COG0363	glucosamine-6-phosphate deaminase activity
KG104_RS03050	COG0747	negative chemotaxis
KG104_RS03060	COG0444	Belongs to the ABC transporter superfamily
KG104_RS03065	COG4608	Belongs to the ABC transporter superfamily
KG104_RS03070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KG104_RS03075	COG1940	carbohydrate kinase activity
KG104_RS03080	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
KG104_RS03090	COG0490	domain, Protein
KG104_RS03090	COG0471	metal ion transport
KG104_RS03115	COG0640	Transcriptional regulator
KG104_RS03125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KG104_RS03145	COG4336	lyase activity
KG104_RS03155	COG0604	alcohol dehydrogenase
KG104_RS03190	COG4213	ABC transporter substrate-binding protein
KG104_RS03195	COG1129	ABC transporter
KG104_RS03200	COG4214	carbohydrate transport
KG104_RS03235	COG1175	transmembrane transport
KG104_RS03245	COG3534	alpha-L-arabinofuranosidase
KG104_RS03250	COG1609	Transcriptional regulator
KG104_RS03270	COG0477	Major facilitator Superfamily
KG104_RS03280	COG0318	PFAM AMP-dependent synthetase and ligase
KG104_RS03300	COG1397	ADP-ribosylglycohydrolase
KG104_RS03325	COG1074	ATP-dependent DNA helicase activity
KG104_RS03365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KG104_RS03395	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KG104_RS03405	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KG104_RS03410	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KG104_RS03445	COG2235	arginine
KG104_RS03455	COG1472	Belongs to the glycosyl hydrolase 3 family
KG104_RS03470	COG0395	ABC-type sugar transport system, permease component
KG104_RS03475	COG1175	transmembrane transport
KG104_RS03485	COG1609	Transcriptional regulator
KG104_RS03490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KG104_RS03500	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KG104_RS03510	COG0179	Fumarylacetoacetate (FAA) hydrolase
KG104_RS03530	COG3842	ATPase activity
KG104_RS03550	COG1960	acyl-CoA dehydrogenase activity
KG104_RS03555	COG2079	MmgE PrpD family protein
KG104_RS03570	COG1024	Enoyl-CoA hydratase
KG104_RS03580	COG1414	Transcriptional regulator
KG104_RS03590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KG104_RS03600	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KG104_RS03620	COG1172	Belongs to the binding-protein-dependent transport system permease family
KG104_RS03625	COG1129	ABC transporter
KG104_RS03630	COG1879	ABC-type sugar transport system periplasmic component
KG104_RS03645	COG1070	Carbohydrate kinase
KG104_RS03685	COG0395	ABC-type sugar transport system, permease component
KG104_RS03690	COG1175	transmembrane transport
KG104_RS03710	COG1486	melibiose metabolic process
KG104_RS03790	COG1063	alcohol dehydrogenase
KG104_RS03815	COG0640	Transcriptional regulator
KG104_RS03820	COG0798	PFAM Bile acid sodium symporter
KG104_RS03825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KG104_RS03835	COG2072	flavoprotein involved in K transport
KG104_RS03855	COG1940	carbohydrate kinase activity
KG104_RS03860	COG2115	Belongs to the xylose isomerase family
KG104_RS03865	COG1070	Carbohydrate kinase
KG104_RS03890	COG3458	cephalosporin-C deacetylase activity
KG104_RS03900	COG2814	Major facilitator Superfamily
KG104_RS03920	COG4565	transcriptional regulatory protein
KG104_RS03925	COG3290	protein histidine kinase activity
KG104_RS03945	COG0589	response to stress
KG104_RS03950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KG104_RS03960	COG0667	Aldo Keto reductase
KG104_RS03965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KG104_RS03970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KG104_RS03975	COG1414	Transcriptional regulator
KG104_RS03985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KG104_RS04000	COG0277	FAD linked oxidase domain protein
KG104_RS04005	COG2188	Transcriptional regulator
KG104_RS04010	COG1620	l-lactate permease
KG104_RS04015	COG0247	lactate metabolic process
KG104_RS04020	COG1139	Iron-sulfur cluster binding protein
KG104_RS04025	COG1556	Lactate utilization protein
KG104_RS04065	COG0683	leucine binding
KG104_RS04075	COG1620	l-lactate permease
KG104_RS04085	COG3619	membrane
KG104_RS04090	COG0405	Gamma-glutamyltransferase
KG104_RS04105	COG0039	L-malate dehydrogenase activity
KG104_RS04110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KG104_RS04145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KG104_RS04150	COG3976	FMN-binding domain protein
KG104_RS04150	COG1053	succinate dehydrogenase
KG104_RS04170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KG104_RS04175	COG4569	acetaldehyde dehydrogenase (acetylating) activity
KG104_RS04180	COG3971	2-oxopent-4-enoate hydratase activity
KG104_RS04185	COG1414	Transcriptional regulator
KG104_RS04195	COG0346	lactoylglutathione lyase activity
KG104_RS04235	COG1278	Cold shock
KG104_RS04250	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KG104_RS04250	COG2066	Belongs to the glutaminase family
KG104_RS04255	COG1278	Cold shock
KG104_RS04260	COG0747	negative chemotaxis
KG104_RS04265	COG0601	transmembrane transport
KG104_RS04270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KG104_RS04295	COG0515	serine threonine protein kinase
KG104_RS04295	COG2815	serine threonine protein kinase
KG104_RS04305	COG3012	SEC-C Motif Domain Protein
KG104_RS04310	COG1063	alcohol dehydrogenase
KG104_RS04320	COG1174	glycine betaine transport
KG104_RS04330	COG1174	glycine betaine transport
KG104_RS04340	COG0471	metal ion transport
KG104_RS04345	COG0596	Alpha beta hydrolase
KG104_RS04350	COG0829	nickel cation binding
KG104_RS04355	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KG104_RS04365	COG0804	urea catabolic process
KG104_RS04370	COG0832	Belongs to the urease beta subunit family
KG104_RS04375	COG0831	urea catabolic process
KG104_RS04395	COG0753	catalase activity
KG104_RS04460	COG0477	Major facilitator Superfamily
KG104_RS04470	COG0138	bifunctional purine biosynthesis protein purh
KG104_RS04530	COG2072	flavoprotein involved in K transport
KG104_RS04535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KG104_RS04540	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KG104_RS04585	COG0180	Tryptophanyl-tRNA synthetase
KG104_RS04600	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KG104_RS04615	COG2009	succinate dehydrogenase
KG104_RS04620	COG0662	Cupin 2, conserved barrel domain protein
KG104_RS04620	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
KG104_RS04625	COG1473	amidohydrolase
KG104_RS04625	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KG104_RS04630	COG1744	ABC transporter substrate-binding protein PnrA-like
KG104_RS04635	COG3845	ABC transporter
KG104_RS04640	COG4603	Belongs to the binding-protein-dependent transport system permease family
KG104_RS04645	COG1079	Belongs to the binding-protein-dependent transport system permease family
KG104_RS04665	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KG104_RS04670	COG3956	TIGRFAM MazG family protein
KG104_RS04675	COG0148	phosphopyruvate hydratase activity
KG104_RS04695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KG104_RS04745	COG2017	converts alpha-aldose to the beta-anomer
KG104_RS04755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KG104_RS04760	COG0705	Rhomboid family
KG104_RS04765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KG104_RS04775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KG104_RS04785	COG1331	Highly conserved protein containing a thioredoxin domain
KG104_RS04800	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KG104_RS04805	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KG104_RS04820	COG1051	belongs to the nudix hydrolase family
KG104_RS04825	COG0477	Major facilitator Superfamily
KG104_RS04835	COG0114	fumarate hydratase activity
KG104_RS04840	COG0288	reversible hydration of carbon dioxide
KG104_RS04850	COG1494	fructose-1,6-bisphosphatase
KG104_RS04865	COG1482	cell wall glycoprotein biosynthetic process
KG104_RS04870	COG1316	TRANSCRIPTIONal
KG104_RS04925	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KG104_RS04950	COG1022	Amp-dependent synthetase and ligase
KG104_RS04980	COG0714	Associated with various cellular activities
KG104_RS04985	COG0084	hydrolase, TatD family'
KG104_RS05000	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KG104_RS05005	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KG104_RS05010	COG0488	(ABC) transporter
KG104_RS05025	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KG104_RS05030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KG104_RS05035	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KG104_RS05040	COG0193	aminoacyl-tRNA hydrolase activity
KG104_RS05085	COG0110	maltose O-acetyltransferase activity
KG104_RS05090	COG2755	lipolytic protein G-D-S-L family
KG104_RS05120	COG0489	protein tyrosine kinase activity
KG104_RS05160	COG0822	iron-sulfur transferase activity
KG104_RS05165	COG1215	transferase activity, transferring glycosyl groups
KG104_RS05175	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KG104_RS05195	COG0489	protein tyrosine kinase activity
KG104_RS05200	COG2244	polysaccharide biosynthetic process
KG104_RS05210	COG0438	transferase activity, transferring glycosyl groups
KG104_RS05220	COG1216	Glycosyl transferase, family 2
KG104_RS05260	COG5002	protein histidine kinase activity
KG104_RS05305	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KG104_RS05345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KG104_RS05370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KG104_RS05395	COG0477	Major facilitator Superfamily
KG104_RS05400	COG4770	biotin carboxylase activity
KG104_RS05410	COG0424	maF-like protein
KG104_RS05415	COG1823	symporter activity
KG104_RS05430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KG104_RS05445	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS05465	COG0631	protein serine/threonine phosphatase activity
KG104_RS05470	COG1674	ftsk spoiiie
KG104_RS05540	COG0601	transmembrane transport
KG104_RS05545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KG104_RS05550	COG0444	Belongs to the ABC transporter superfamily
KG104_RS05555	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KG104_RS05570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KG104_RS05575	COG0154	amidase activity
KG104_RS05580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KG104_RS05600	COG1254	Belongs to the acylphosphatase family
KG104_RS05605	COG2986	histidine ammonia-lyase
KG104_RS05615	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KG104_RS05630	COG1228	amidohydrolase
KG104_RS05655	COG3250	beta-galactosidase activity
KG104_RS05670	COG2873	o-acetylhomoserine
KG104_RS05675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KG104_RS05715	COG2837	iron assimilation
KG104_RS05730	COG0423	glycine-tRNA ligase activity
KG104_RS05740	COG1309	transcriptional regulator
KG104_RS05750	COG2031	fatty acid transporter
KG104_RS05770	COG0358	DNA primase activity
KG104_RS05790	COG0281	malic enzyme
KG104_RS05795	COG0477	Major facilitator Superfamily
KG104_RS05805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KG104_RS05815	COG0297	glycogen (starch) synthase activity
KG104_RS05825	COG1960	acyl-CoA dehydrogenase activity
KG104_RS05835	COG0052	Belongs to the universal ribosomal protein uS2 family
KG104_RS05840	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KG104_RS05845	COG0528	UMP kinase activity
KG104_RS05850	COG0233	cytoplasmic translational termination
KG104_RS05855	COG0575	Belongs to the CDS family
KG104_RS05865	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KG104_RS05875	COG3279	Response regulator of the LytR AlgR family
KG104_RS05880	COG3275	phosphorelay sensor kinase activity
KG104_RS05890	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KG104_RS05905	COG0022	dehydrogenase e1 component
KG104_RS05910	COG0508	dehydrogenase complex catalyzes the overall conversion of
KG104_RS05920	COG1309	transcriptional regulator
KG104_RS05925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KG104_RS05935	COG1960	acyl-CoA dehydrogenase activity
KG104_RS05965	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KG104_RS05970	COG0750	zinc metalloprotease
KG104_RS05990	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KG104_RS06010	COG0442	prolyl-tRNA aminoacylation
KG104_RS06035	COG0195	Participates in both transcription termination and antitermination
KG104_RS06045	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KG104_RS06050	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KG104_RS06065	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KG104_RS06090	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KG104_RS06095	COG1185	polyribonucleotide nucleotidyltransferase activity
KG104_RS06100	COG0612	Peptidase, M16
KG104_RS06150	COG0315	cyclic pyranopterin monophosphate synthase activity
KG104_RS06155	COG0521	Mo-molybdopterin cofactor biosynthetic process
KG104_RS06165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KG104_RS06180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KG104_RS06185	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KG104_RS06190	COG1674	ftsk spoiiie
KG104_RS06200	COG1546	Belongs to the CinA family
KG104_RS06200	COG1058	Belongs to the CinA family
KG104_RS06205	COG1396	sequence-specific DNA binding
KG104_RS06220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KG104_RS06225	COG2137	regulation of response to DNA damage stimulus
KG104_RS06240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KG104_RS06245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KG104_RS06250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KG104_RS06255	COG2813	Specifically methylates the guanine in position
KG104_RS06260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KG104_RS06270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KG104_RS06280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KG104_RS06285	COG0131	Imidazoleglycerol-phosphate dehydratase
KG104_RS06290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KG104_RS06300	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KG104_RS06330	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KG104_RS06335	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KG104_RS06340	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KG104_RS06345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KG104_RS06355	COG2814	Major facilitator Superfamily
KG104_RS06360	COG0494	nUDIX hydrolase
KG104_RS06375	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KG104_RS06380	COG0072	phenylalanine-tRNA ligase activity
KG104_RS06380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KG104_RS06405	COG0438	transferase activity, transferring glycosyl groups
KG104_RS06415	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KG104_RS06420	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KG104_RS06425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KG104_RS06430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KG104_RS06435	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KG104_RS06440	COG1438	arginine binding
KG104_RS06445	COG0137	argininosuccinate synthase activity
KG104_RS06450	COG0165	Argininosuccinate lyase
KG104_RS06475	COG2094	Belongs to the DNA glycosylase MPG family
KG104_RS06485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KG104_RS06495	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KG104_RS06520	COG0647	UMP catabolic process
KG104_RS06535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KG104_RS06540	COG0497	DNA recombination
KG104_RS06545	COG0504	CTP synthase activity
KG104_RS06550	COG0494	nUDIX hydrolase
KG104_RS06575	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KG104_RS06580	COG2079	MmgE PrpD family protein
KG104_RS06600	COG4565	transcriptional regulatory protein
KG104_RS06605	COG3290	protein histidine kinase activity
KG104_RS06610	COG1301	dicarboxylic acid transport
KG104_RS06620	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KG104_RS06625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KG104_RS06640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KG104_RS06645	COG1160	GTP binding
KG104_RS06665	COG1672	PFAM Archaeal ATPase
KG104_RS06665	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
KG104_RS06670	COG2133	pyrroloquinoline quinone binding
KG104_RS06685	COG0300	oxidoreductase activity
KG104_RS06695	COG1716	ATPase activity
KG104_RS06720	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KG104_RS06735	COG1940	carbohydrate kinase activity
KG104_RS06755	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KG104_RS06760	COG0515	serine threonine protein kinase
KG104_RS06760	COG2815	serine threonine protein kinase
KG104_RS06765	COG1388	LysM domain
KG104_RS06765	COG3942	CHAP domain
KG104_RS06775	COG0142	geranyltranstransferase activity
KG104_RS06785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KG104_RS06795	COG2001	Belongs to the MraZ family
KG104_RS06800	COG0275	rRNA processing
KG104_RS06810	COG0768	penicillin binding
KG104_RS06820	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KG104_RS06825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KG104_RS06830	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KG104_RS06840	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KG104_RS06845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KG104_RS06855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KG104_RS06860	COG1496	oxidoreductase activity
KG104_RS06865	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KG104_RS06870	COG1799	cell septum assembly
KG104_RS06880	COG3599	regulation of cell shape
KG104_RS06885	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KG104_RS06895	COG0587	DNA-directed DNA polymerase activity
KG104_RS06900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KG104_RS06905	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KG104_RS06925	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KG104_RS06930	COG0174	glutamine synthetase
KG104_RS06935	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KG104_RS06940	COG0765	amino acid transport
KG104_RS06945	COG1126	abc transporter atp-binding protein
KG104_RS07005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KG104_RS07010	COG0321	lipoyl(octanoyl) transferase activity
KG104_RS07020	COG0793	Belongs to the peptidase S41A family
KG104_RS07020	COG4946	Tricorn protease homolog
KG104_RS07025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KG104_RS07030	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KG104_RS07035	COG1609	Transcriptional regulator
KG104_RS07045	COG1175	transmembrane transport
KG104_RS07050	COG0395	ABC-type sugar transport system, permease component
KG104_RS07055	COG1472	Belongs to the glycosyl hydrolase 3 family
KG104_RS07070	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
KG104_RS07075	COG0829	nickel cation binding
KG104_RS07080	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KG104_RS07085	COG0830	nickel cation binding
KG104_RS07090	COG0804	urea catabolic process
KG104_RS07105	COG0831	urea catabolic process
KG104_RS07110	COG1764	response to oxidative stress
KG104_RS07120	COG0508	dehydrogenase complex catalyzes the overall conversion of
KG104_RS07125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KG104_RS07130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KG104_RS07150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KG104_RS07160	COG0187	DNA topoisomerase II activity
KG104_RS07175	COG1271	oxidase subunit
KG104_RS07180	COG1294	oxidase, subunit
KG104_RS07185	COG4988	ABC transporter
KG104_RS07205	COG1064	alcohol dehydrogenase
KG104_RS07210	COG1309	transcriptional regulator
KG104_RS07230	COG1937	Protein conserved in bacteria
KG104_RS07245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KG104_RS07265	COG1435	thymidine kinase activity
KG104_RS07275	COG1395	domain, Protein
KG104_RS07295	COG0756	dUTP diphosphatase activity
KG104_RS07320	COG0569	domain protein
KG104_RS07325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KG104_RS07330	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KG104_RS07335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KG104_RS07340	COG0702	epimerase
KG104_RS07350	COG0667	Aldo Keto reductase
KG104_RS07390	COG5002	protein histidine kinase activity
KG104_RS07390	COG5000	phosphorelay sensor kinase activity
KG104_RS07395	COG0745	RESPONSE REGULATOR receiver
KG104_RS07405	COG1929	Belongs to the glycerate kinase type-1 family
KG104_RS07460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KG104_RS07485	COG0673	inositol 2-dehydrogenase activity
KG104_RS07495	COG1250	3-hydroxyacyl-CoA dehydrogenase
KG104_RS07495	COG1024	Enoyl-CoA hydratase
KG104_RS07500	COG0183	Belongs to the thiolase family
KG104_RS07550	COG0737	Belongs to the 5'-nucleotidase family
KG104_RS07570	COG0454	-acetyltransferase
KG104_RS07570	COG0456	acetyltransferase
KG104_RS07620	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KG104_RS07625	COG0183	Belongs to the thiolase family
KG104_RS07640	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KG104_RS07655	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
KG104_RS07675	COG1269	ATP hydrolysis coupled proton transport
KG104_RS07700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KG104_RS07720	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KG104_RS07790	COG0242	peptide deformylase activity
KG104_RS07795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KG104_RS07805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KG104_RS07825	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KG104_RS07825	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KG104_RS07830	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KG104_RS07830	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KG104_RS07835	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KG104_RS07845	COG1970	mechanosensitive ion channel activity
KG104_RS07850	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS07855	COG1473	amidohydrolase
KG104_RS07860	COG2814	Major facilitator Superfamily
KG104_RS07870	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KG104_RS07880	COG0477	Major facilitator Superfamily
KG104_RS07905	COG4941	Belongs to the sigma-70 factor family
KG104_RS07910	COG3795	YCII-related domain
KG104_RS07915	COG0140	phosphoribosyl-ATP diphosphatase activity
KG104_RS07920	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KG104_RS07925	COG0107	imidazoleglycerol-phosphate synthase activity
KG104_RS07935	COG1064	alcohol dehydrogenase
KG104_RS07950	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KG104_RS07970	COG0134	indole-3-glycerol-phosphate synthase activity
KG104_RS07975	COG0133	tryptophan synthase activity
KG104_RS07980	COG0159	tryptophan synthase activity
KG104_RS07985	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KG104_RS07990	COG0070	glutamate synthase
KG104_RS07990	COG0069	glutamate synthase activity
KG104_RS07990	COG0067	glutamate synthase
KG104_RS08005	COG0469	pyruvate kinase activity
KG104_RS08025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KG104_RS08035	COG3962	Belongs to the TPP enzyme family
KG104_RS08040	COG1082	Xylose isomerase domain protein TIM barrel
KG104_RS08045	COG0673	inositol 2-dehydrogenase activity
KG104_RS08050	COG1082	Xylose isomerase domain protein TIM barrel
KG104_RS08055	COG2814	Major facilitator Superfamily
KG104_RS08060	COG3718	enzyme involved in inositol metabolism
KG104_RS08065	COG2188	Transcriptional regulator
KG104_RS08070	COG1879	ABC-type sugar transport system periplasmic component
KG104_RS08075	COG1172	Belongs to the binding-protein-dependent transport system permease family
KG104_RS08085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KG104_RS08120	COG0385	Bile acid
KG104_RS08140	COG1131	(ABC) transporter
KG104_RS08155	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KG104_RS08165	COG1329	Transcriptional regulator
KG104_RS08180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KG104_RS08185	COG0601	transmembrane transport
KG104_RS08190	COG0747	negative chemotaxis
KG104_RS08195	COG0477	Major facilitator Superfamily
KG104_RS08220	COG1132	(ABC) transporter
KG104_RS08245	COG1361	Conserved repeat domain
KG104_RS08255	COG3268	Saccharopine dehydrogenase
KG104_RS08260	COG2197	response regulator
KG104_RS08290	COG0656	L-ascorbic acid biosynthetic process
KG104_RS08315	COG1742	UPF0060 membrane protein
KG104_RS08320	COG1854	S-ribosylhomocysteine lyase activity
KG104_RS08325	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KG104_RS08330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KG104_RS08335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KG104_RS08470	COG1902	pentaerythritol trinitrate reductase activity
KG104_RS08495	COG1120	ATPase activity
KG104_RS08505	COG3422	double-strand break repair
KG104_RS08530	COG0628	permease
KG104_RS08535	COG0110	maltose O-acetyltransferase activity
KG104_RS08550	COG0366	Alpha amylase catalytic
KG104_RS08555	COG1609	Transcriptional regulator
KG104_RS08565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KG104_RS08605	COG1196	nuclear chromosome segregation
KG104_RS08615	COG1802	Transcriptional regulator
KG104_RS08620	COG1012	belongs to the aldehyde dehydrogenase family
KG104_RS08630	COG3971	2-oxopent-4-enoate hydratase activity
KG104_RS08660	COG5650	phosphatidylinositol metabolic process
KG104_RS08695	COG2890	protein-(glutamine-N5) methyltransferase activity
KG104_RS08710	COG1643	Atp-dependent helicase
KG104_RS08725	COG2205	protein histidine kinase activity
KG104_RS08735	COG0791	NLP P60 protein
KG104_RS08735	COG1388	LysM domain
KG104_RS08735	COG3103	Sh3 type 3 domain protein
KG104_RS08745	COG2197	response regulator
KG104_RS08755	COG1136	(ABC) transporter
KG104_RS08765	COG2814	Major facilitator Superfamily
KG104_RS08780	COG1960	acyl-CoA dehydrogenase activity
KG104_RS08795	COG0488	(ABC) transporter
KG104_RS08800	COG1960	acyl-CoA dehydrogenase activity
KG104_RS08805	COG1960	acyl-CoA dehydrogenase activity
KG104_RS08810	COG0183	Belongs to the thiolase family
KG104_RS08825	COG2030	dehydratase
KG104_RS08830	COG0318	PFAM AMP-dependent synthetase and ligase
KG104_RS08845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KG104_RS08855	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS08860	COG2072	flavoprotein involved in K transport
KG104_RS08865	COG0657	acetylesterase activity
KG104_RS08875	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS08885	COG0300	oxidoreductase activity
KG104_RS08890	COG0559	Belongs to the binding-protein-dependent transport system permease family
KG104_RS08910	COG0183	Belongs to the thiolase family
KG104_RS08915	COG0318	PFAM AMP-dependent synthetase and ligase
KG104_RS08920	COG1309	transcriptional regulator
KG104_RS08945	COG1960	acyl-CoA dehydrogenase activity
KG104_RS08950	COG1960	acyl-CoA dehydrogenase activity
KG104_RS08955	COG1960	acyl-CoA dehydrogenase activity
KG104_RS08960	COG1024	Enoyl-CoA hydratase
KG104_RS08965	COG1960	acyl-CoA dehydrogenase activity
KG104_RS08970	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS08975	COG0183	Belongs to the thiolase family
KG104_RS09000	COG1024	Enoyl-CoA hydratase
KG104_RS09005	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS09015	COG2086	electron transfer activity
KG104_RS09020	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KG104_RS09030	COG2072	flavoprotein involved in K transport
KG104_RS09040	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KG104_RS09065	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KG104_RS09075	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
KG104_RS09110	COG0009	L-threonylcarbamoyladenylate synthase
KG104_RS09120	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS09130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KG104_RS09145	COG0277	FAD linked oxidase domain protein
KG104_RS09150	COG2160	L-arabinose isomerase activity
KG104_RS09165	COG1609	Transcriptional regulator
KG104_RS09170	COG2017	converts alpha-aldose to the beta-anomer
KG104_RS09175	COG1136	(ABC) transporter
KG104_RS09185	COG4585	Histidine kinase
KG104_RS09190	COG2197	response regulator
KG104_RS09195	COG0366	Alpha amylase catalytic
KG104_RS09200	COG2814	Major facilitator Superfamily
KG104_RS09210	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KG104_RS09215	COG1215	transferase activity, transferring glycosyl groups
KG104_RS09235	COG0471	metal ion transport
KG104_RS09245	COG0473	3-isopropylmalate dehydrogenase activity
KG104_RS09260	COG1063	alcohol dehydrogenase
KG104_RS09265	COG1609	Transcriptional regulator
KG104_RS09275	COG1175	transmembrane transport
KG104_RS09325	COG0542	response to heat
KG104_RS09330	COG4941	Belongs to the sigma-70 factor family
KG104_RS09350	COG0242	peptide deformylase activity
KG104_RS09355	COG1506	peptidase
KG104_RS09355	COG4946	Tricorn protease homolog
KG104_RS09355	COG0823	Involved in the tonB-independent uptake of proteins
KG104_RS09380	COG1216	Glycosyl transferase, family 2
KG104_RS09390	COG4581	dead DEAH box helicase
KG104_RS09395	COG0805	protein transport
KG104_RS09400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KG104_RS09425	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KG104_RS09430	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KG104_RS09435	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KG104_RS09445	COG4122	O-methyltransferase activity
KG104_RS09460	COG1994	Peptidase M50
KG104_RS09460	COG0517	IMP dehydrogenase activity
KG104_RS09465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KG104_RS09475	COG0215	cysteine-tRNA ligase activity
KG104_RS09480	COG1968	undecaprenyl-diphosphatase activity
KG104_RS09495	COG1960	acyl-CoA dehydrogenase activity
KG104_RS09500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KG104_RS09510	COG1253	flavin adenine dinucleotide binding
KG104_RS09520	COG0589	response to stress
KG104_RS09525	COG4214	carbohydrate transport
KG104_RS09530	COG1129	ABC transporter
KG104_RS09535	COG4213	ABC transporter substrate-binding protein
KG104_RS09545	COG2030	dehydratase
KG104_RS09550	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS09555	COG0183	Belongs to the thiolase family
KG104_RS09570	COG0297	glycogen (starch) synthase activity
KG104_RS09585	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KG104_RS09590	COG2855	membrane
KG104_RS09615	COG0254	rRNA binding
KG104_RS09635	COG1119	ATPase activity
KG104_RS09640	COG3830	Belongs to the UPF0237 family
KG104_RS09640	COG0560	Phosphoserine phosphatase
KG104_RS09645	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS09680	COG0488	(ABC) transporter
KG104_RS09685	COG1268	BioY protein
KG104_RS09690	COG1122	ATPase activity
KG104_RS09715	COG2151	metal-sulfur cluster biosynthetic enzyme
KG104_RS09720	COG0396	ATPase activity
KG104_RS09740	COG1131	(ABC) transporter
KG104_RS09755	COG0109	protoheme IX farnesyltransferase activity
KG104_RS09765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KG104_RS09785	COG0363	glucosamine-6-phosphate deaminase activity
KG104_RS09790	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KG104_RS09795	COG0149	triose-phosphate isomerase activity
KG104_RS09800	COG0126	phosphoglycerate kinase activity
KG104_RS09815	COG1481	regulation of sporulation
KG104_RS09820	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KG104_RS09825	COG1660	Displays ATPase and GTPase activities
KG104_RS09830	COG0322	excinuclease ABC activity
KG104_RS09870	COG0531	amino acid
KG104_RS09875	COG4106	trans-aconitate 2-methyltransferase activity
KG104_RS09905	COG0556	nucleotide-excision repair
KG104_RS09910	COG0237	dephospho-CoA kinase activity
KG104_RS09910	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KG104_RS09915	COG1739	Uncharacterized protein family UPF0029
KG104_RS09920	COG2890	protein-(glutamine-N5) methyltransferase activity
KG104_RS09930	COG1175	transmembrane transport
KG104_RS09940	COG2723	6-phospho-beta-galactosidase activity
KG104_RS09950	COG0673	inositol 2-dehydrogenase activity
KG104_RS09955	COG0539	negative regulation of cytoplasmic translation
KG104_RS09960	COG4552	Acetyltransferase involved in intracellular survival and related
KG104_RS09970	COG2050	protein possibly involved in aromatic compounds catabolism
KG104_RS10000	COG2814	Major facilitator Superfamily
KG104_RS10010	COG0076	glutamate decarboxylase activity
KG104_RS10015	COG0531	amino acid
KG104_RS10020	COG2066	Belongs to the glutaminase family
KG104_RS10025	COG1414	Transcriptional regulator
KG104_RS10030	COG3185	4-Hydroxyphenylpyruvate dioxygenase
KG104_RS10030	COG1082	Xylose isomerase domain protein TIM barrel
KG104_RS10035	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KG104_RS10045	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KG104_RS10050	COG1472	Belongs to the glycosyl hydrolase 3 family
KG104_RS10060	COG1607	acyl-coa hydrolase
KG104_RS10080	COG2272	Belongs to the type-B carboxylesterase lipase family
KG104_RS10095	COG0488	(ABC) transporter
KG104_RS10120	COG0415	Belongs to the DNA photolyase family
KG104_RS10130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KG104_RS10140	COG1012	belongs to the aldehyde dehydrogenase family
KG104_RS10155	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KG104_RS10160	COG1960	acyl-CoA dehydrogenase activity
KG104_RS10165	COG2391	methyltransferase activity
KG104_RS10170	COG0425	Belongs to the sulfur carrier protein TusA family
KG104_RS10180	COG0318	PFAM AMP-dependent synthetase and ligase
KG104_RS10185	COG0667	Aldo Keto reductase
KG104_RS10190	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS10205	COG1309	transcriptional regulator
KG104_RS10220	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS10235	COG1136	(ABC) transporter
KG104_RS10255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KG104_RS10260	COG1845	cytochrome c oxidase, subunit III
KG104_RS10265	COG2010	Cytochrome c
KG104_RS10270	COG0723	plastoquinol--plastocyanin reductase activity
KG104_RS10275	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KG104_RS10285	COG2188	Transcriptional regulator
KG104_RS10295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KG104_RS10300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KG104_RS10320	COG0167	dihydroorotate dehydrogenase activity
KG104_RS10330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KG104_RS10335	COG1381	Involved in DNA repair and RecF pathway recombination
KG104_RS10340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KG104_RS10345	COG1316	TRANSCRIPTIONal
KG104_RS10350	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KG104_RS10360	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KG104_RS10380	COG0484	heat shock protein binding
KG104_RS10385	COG1420	regulation of RNA biosynthetic process
KG104_RS10405	COG0481	GTPase activity
KG104_RS10415	COG0268	Binds directly to 16S ribosomal RNA
KG104_RS10430	COG1555	photosystem II stabilization
KG104_RS10430	COG1596	polysaccharide export
KG104_RS10445	COG0697	spore germination
KG104_RS10470	COG1307	EDD domain protein, DegV family
KG104_RS10475	COG0495	leucyl-tRNA aminoacylation
KG104_RS10480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KG104_RS10495	COG0385	Bile acid
KG104_RS10500	COG2072	flavoprotein involved in K transport
KG104_RS10505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KG104_RS10510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KG104_RS10515	COG0656	L-ascorbic acid biosynthetic process
KG104_RS10525	COG0438	transferase activity, transferring glycosyl groups
KG104_RS10535	COG2130	NADP-dependent
KG104_RS10540	COG1846	Transcriptional regulator
KG104_RS10545	COG0842	Transport permease protein
KG104_RS10545	COG1129	ABC transporter
KG104_RS10565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KG104_RS10575	COG1758	RNA polymerase activity
KG104_RS10580	COG0194	GDP metabolic process
KG104_RS10585	COG0194	GDP metabolic process
KG104_RS10590	COG0284	orotidine-5'-phosphate decarboxylase activity
KG104_RS10595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KG104_RS10600	COG0505	Belongs to the CarA family
KG104_RS10610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KG104_RS10615	COG0540	Belongs to the ATCase OTCase family
KG104_RS10620	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KG104_RS10630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KG104_RS10635	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KG104_RS10640	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KG104_RS10645	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KG104_RS10650	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KG104_RS10655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KG104_RS10665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KG104_RS10670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KG104_RS10685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KG104_RS10705	COG0384	phenazine biosynthesis protein PhzF
KG104_RS10720	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KG104_RS10730	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KG104_RS10740	COG4585	Histidine kinase
KG104_RS10745	COG2197	response regulator
KG104_RS10750	COG0124	histidyl-tRNA synthetase
KG104_RS10755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KG104_RS10760	COG1196	nuclear chromosome segregation
KG104_RS10770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KG104_RS10775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KG104_RS10780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KG104_RS10790	COG2255	four-way junction helicase activity
KG104_RS10795	COG0632	four-way junction helicase activity
KG104_RS10800	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KG104_RS10805	COG0217	transcriptional regulatory protein
KG104_RS10810	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KG104_RS10815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KG104_RS10835	COG0339	signal peptide processing
KG104_RS10850	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KG104_RS10855	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KG104_RS10865	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KG104_RS10870	COG0587	DNA-directed DNA polymerase activity
KG104_RS10905	COG2409	Drug exporters of the RND superfamily
KG104_RS10915	COG2135	peptidase activity
KG104_RS10975	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KG104_RS11005	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
KG104_RS11015	COG3896	Chloramphenicol phosphotransferase-like protein
KG104_RS11045	COG1136	(ABC) transporter
KG104_RS11045	COG0577	efflux transmembrane transporter activity
KG104_RS11070	COG0494	nUDIX hydrolase
KG104_RS11080	COG4552	Acetyltransferase involved in intracellular survival and related
KG104_RS11125	COG3226	Transcriptional regulator
KG104_RS11145	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
KG104_RS11150	COG1181	Belongs to the D-alanine--D-alanine ligase family
KG104_RS11220	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KG104_RS11225	COG0659	secondary active sulfate transmembrane transporter activity
KG104_RS11270	COG0656	L-ascorbic acid biosynthetic process
KG104_RS11275	COG0667	Aldo Keto reductase
KG104_RS11280	COG2135	peptidase activity
KG104_RS11310	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS11315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KG104_RS11325	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KG104_RS11360	COG2318	DinB family
KG104_RS11375	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KG104_RS11385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KG104_RS11390	COG1780	Probably involved in ribonucleotide reductase function
KG104_RS11400	COG0583	DNA-binding transcription factor activity
KG104_RS11445	COG0406	alpha-ribazole phosphatase activity
KG104_RS11460	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KG104_RS11470	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KG104_RS11475	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KG104_RS11480	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KG104_RS11485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KG104_RS11490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KG104_RS11495	COG1530	ribonuclease E activity
KG104_RS11515	COG2239	Acts as a magnesium transporter
KG104_RS11520	COG0105	UTP biosynthetic process
KG104_RS11530	COG0285	dihydrofolate synthase activity
KG104_RS11535	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KG104_RS11550	COG3189	MarR family transcriptional regulator
KG104_RS11555	COG0525	valine-tRNA ligase activity
KG104_RS11560	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KG104_RS11565	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KG104_RS11570	COG0740	serine-type endopeptidase activity
KG104_RS11580	COG0544	peptidyl-prolyl cis-trans isomerase activity
KG104_RS11605	COG0698	ribose 5-phosphate isomerase
KG104_RS11625	COG0668	transmembrane transport
KG104_RS11645	COG1946	Acyl-CoA thioesterase
KG104_RS11660	COG0629	single-stranded DNA binding
KG104_RS11750	COG3022	response to hydroperoxide
KG104_RS11765	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KG104_RS11770	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KG104_RS11780	COG1045	serine acetyltransferase
KG104_RS11785	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KG104_RS11815	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KG104_RS11830	COG2186	Transcriptional regulator
KG104_RS11860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KG104_RS11865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KG104_RS11870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KG104_RS11880	COG4974	Belongs to the 'phage' integrase family
KG104_RS11900	COG0792	nuclease activity
KG104_RS11930	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KG104_RS11940	COG0681	Belongs to the peptidase S26 family
KG104_RS11945	COG0335	large ribosomal subunit rRNA binding
KG104_RS11950	COG0336	Belongs to the RNA methyltransferase TrmD family
KG104_RS11955	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KG104_RS11960	COG1837	Belongs to the UPF0109 family
KG104_RS11965	COG0228	four-way junction DNA binding
KG104_RS11970	COG2514	catechol 2,3-dioxygenase activity
KG104_RS11995	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KG104_RS12060	COG0477	Major facilitator Superfamily
KG104_RS12075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KG104_RS12080	COG0318	PFAM AMP-dependent synthetase and ligase
KG104_RS12085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KG104_RS12090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KG104_RS12095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KG104_RS12105	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KG104_RS12125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KG104_RS12140	COG0742	ribosomal rna small subunit methyltransferase
KG104_RS12150	COG1461	Dihydroxyacetone kinase
KG104_RS12160	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KG104_RS12175	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KG104_RS12180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KG104_RS12185	COG1215	transferase activity, transferring glycosyl groups
KG104_RS12185	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KG104_RS12205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KG104_RS12205	COG1215	transferase activity, transferring glycosyl groups
KG104_RS12210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KG104_RS12215	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KG104_RS12225	COG1134	teichoic acid transport
KG104_RS12230	COG1682	transport, permease protein
KG104_RS12250	COG1316	TRANSCRIPTIONal
KG104_RS12260	COG1181	Belongs to the D-alanine--D-alanine ligase family
KG104_RS12265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KG104_RS12275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KG104_RS12280	COG0066	3-isopropylmalate dehydratase activity
KG104_RS12285	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KG104_RS12290	COG1414	Transcriptional regulator
KG104_RS12315	COG0546	phosphoglycolate phosphatase activity
KG104_RS12320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KG104_RS12350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KG104_RS12355	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KG104_RS12360	COG0473	3-isopropylmalate dehydrogenase activity
KG104_RS12365	COG4585	Histidine kinase
KG104_RS12370	COG2197	response regulator
KG104_RS12380	COG0577	efflux transmembrane transporter activity
KG104_RS12380	COG1136	(ABC) transporter
KG104_RS12410	COG0577	efflux transmembrane transporter activity
KG104_RS12410	COG1136	(ABC) transporter
KG104_RS12415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KG104_RS12420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KG104_RS12425	COG0440	acetolactate synthase activity
KG104_RS12435	COG0129	dihydroxy-acid dehydratase activity
KG104_RS12485	COG0747	negative chemotaxis
KG104_RS12490	COG0601	transmembrane transport
KG104_RS12495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KG104_RS12505	COG0747	negative chemotaxis
KG104_RS12510	COG0579	oxidoreductase
KG104_RS12515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KG104_RS12540	COG0300	oxidoreductase activity
KG104_RS12550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KG104_RS12575	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KG104_RS12580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KG104_RS12600	COG1113	amino acid transport
KG104_RS12615	COG0515	serine threonine protein kinase
KG104_RS12615	COG2815	serine threonine protein kinase
KG104_RS12630	COG0419	ATPase involved in DNA repair
KG104_RS12635	COG0420	3'-5' exonuclease activity
KG104_RS12655	COG0586	Pfam SNARE associated Golgi protein
KG104_RS12660	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KG104_RS12665	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KG104_RS12675	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KG104_RS12685	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KG104_RS12690	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KG104_RS12695	COG1335	isochorismatase
KG104_RS12720	COG1131	(ABC) transporter
KG104_RS12725	COG1902	pentaerythritol trinitrate reductase activity
KG104_RS12750	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
KG104_RS12760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KG104_RS12770	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KG104_RS12775	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KG104_RS12780	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KG104_RS12785	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KG104_RS12790	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KG104_RS12795	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KG104_RS12800	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KG104_RS12805	COG0356	it plays a direct role in the translocation of protons across the membrane
KG104_RS12820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KG104_RS12850	COG2890	protein-(glutamine-N5) methyltransferase activity
KG104_RS12855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KG104_RS12865	COG0083	homoserine kinase activity
KG104_RS12870	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KG104_RS12875	COG0460	homoserine dehydrogenase
KG104_RS12880	COG0019	diaminopimelate decarboxylase activity
KG104_RS12885	COG0018	arginyl-trna synthetase
KG104_RS12900	COG1017	nitric oxide dioxygenase activity
KG104_RS12900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KG104_RS12965	COG1643	Atp-dependent helicase
KG104_RS12970	COG0537	adenosine 5'-monophosphoramidase activity
KG104_RS12980	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KG104_RS12990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KG104_RS12995	COG1121	(ABC) transporter
KG104_RS13010	COG1253	flavin adenine dinucleotide binding
KG104_RS13015	COG0508	dehydrogenase complex catalyzes the overall conversion of
KG104_RS13015	COG0567	Dehydrogenase, E1 component
KG104_RS13025	COG0747	negative chemotaxis
KG104_RS13035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KG104_RS13050	COG1595	DNA-templated transcription, initiation
KG104_RS13060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KG104_RS13070	COG0483	inositol monophosphate 1-phosphatase activity
KG104_RS13080	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KG104_RS13090	COG0366	Alpha amylase catalytic
KG104_RS13115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KG104_RS13125	COG2177	Part of the ABC transporter FtsEX involved in
KG104_RS13130	COG2884	Cell division ATP-binding protein ftsE
KG104_RS13135	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS13140	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KG104_RS13205	COG1216	Glycosyl transferase, family 2
KG104_RS13220	COG1088	dTDP-glucose 4,6-dehydratase activity
KG104_RS13230	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KG104_RS13250	COG1216	Glycosyl transferase, family 2
KG104_RS13260	COG2755	lipolytic protein G-D-S-L family
KG104_RS13260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KG104_RS13280	COG2902	Dehydrogenase
KG104_RS13315	COG0653	protein targeting
KG104_RS13320	COG3214	Protein conserved in bacteria
KG104_RS13325	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KG104_RS13335	COG5401	PFAM Sporulation and spore germination
KG104_RS13340	COG5002	protein histidine kinase activity
KG104_RS13345	COG0745	RESPONSE REGULATOR receiver
KG104_RS13365	COG0714	Associated with various cellular activities
KG104_RS13390	COG0482	sulfurtransferase activity
KG104_RS13410	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KG104_RS13415	COG4106	trans-aconitate 2-methyltransferase activity
KG104_RS13420	COG1595	DNA-templated transcription, initiation
KG104_RS13435	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KG104_RS13440	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KG104_RS13450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KG104_RS13460	COG1842	Phage shock protein A
KG104_RS13470	COG1615	UPF0182 protein
KG104_RS13475	COG3480	Lon protease (S16) C-terminal proteolytic domain
KG104_RS13545	COG0210	DNA helicase
KG104_RS13565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KG104_RS13575	COG1464	Belongs to the NlpA lipoprotein family
KG104_RS13580	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KG104_RS13585	COG0113	porphobilinogen synthase activity
KG104_RS13595	COG0181	hydroxymethylbilane synthase activity
KG104_RS13600	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KG104_RS13605	COG3253	May function as heme-dependent peroxidase
KG104_RS13610	COG1231	oxidoreductase activity
KG104_RS13615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KG104_RS13620	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KG104_RS13655	COG0513	Belongs to the DEAD box helicase family
KG104_RS13670	COG0006	proline dipeptidase activity
KG104_RS13680	COG2239	Acts as a magnesium transporter
KG104_RS13695	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KG104_RS13705	COG1595	DNA-templated transcription, initiation
KG104_RS13715	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KG104_RS13730	COG0519	Catalyzes the synthesis of GMP from XMP
KG104_RS13740	COG1611	Belongs to the LOG family
KG104_RS13745	COG1126	abc transporter atp-binding protein
KG104_RS13750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KG104_RS13755	COG0765	amino acid transport
KG104_RS13760	COG0765	amino acid transport
KG104_RS13765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KG104_RS13770	COG2171	N-acyltransferase activity
KG104_RS13780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KG104_RS13810	COG1217	gtp-binding protein TYPA
KG104_RS13820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KG104_RS13825	COG0601	transmembrane transport
KG104_RS13830	COG0747	negative chemotaxis
KG104_RS13835	COG0747	negative chemotaxis
KG104_RS13845	COG3507	Belongs to the glycosyl hydrolase 43 family
KG104_RS13850	COG1472	Belongs to the glycosyl hydrolase 3 family
KG104_RS13865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KG104_RS13870	COG0601	transmembrane transport
KG104_RS13885	COG0494	nUDIX hydrolase
KG104_RS13915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KG104_RS13930	COG0012	GTP binding
KG104_RS13935	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KG104_RS13945	COG1570	exodeoxyribonuclease VII activity
KG104_RS13950	COG1722	exodeoxyribonuclease VII activity
KG104_RS13965	COG1174	glycine betaine transport
KG104_RS13970	COG1174	glycine betaine transport
KG104_RS13985	COG2971	BadF BadG BcrA BcrD
KG104_RS14005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KG104_RS14010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KG104_RS14035	COG0519	Catalyzes the synthesis of GMP from XMP
KG104_RS14035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KG104_RS14055	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KG104_RS14060	COG0516	GMP reductase activity
KG104_RS14070	COG0459	protein refolding
KG104_RS14075	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KG104_RS14080	COG4607	ABC-type enterochelin transport system periplasmic component
KG104_RS14085	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KG104_RS14090	COG4605	iron ion homeostasis
KG104_RS14095	COG4604	ABC transporter, ATP-binding protein
KG104_RS14125	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KG104_RS14135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KG104_RS14140	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KG104_RS14150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KG104_RS14160	COG0456	acetyltransferase
KG104_RS14160	COG1214	PFAM Peptidase M22, glycoprotease
KG104_RS14165	COG0802	atpase or kinase
KG104_RS14170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KG104_RS14175	COG0667	Aldo Keto reductase
KG104_RS14195	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KG104_RS14200	COG0736	holo-[acyl-carrier-protein] synthase activity
KG104_RS14205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KG104_RS14210	COG1072	(Pantothenic acid kinase))
KG104_RS14215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KG104_RS14220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KG104_RS14225	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KG104_RS14230	COG0101	tRNA pseudouridine synthase activity
KG104_RS14235	COG0203	ribosomal protein L17
KG104_RS14240	COG0202	RNA polymerase activity
KG104_RS14245	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KG104_RS14250	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KG104_RS14255	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KG104_RS14260	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KG104_RS14265	COG0024	Methionine aminopeptidase
KG104_RS14270	COG0563	adenylate kinase activity
KG104_RS14280	COG0200	Binds to the 23S rRNA
KG104_RS14285	COG1841	ribosomal large subunit assembly
KG104_RS14290	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KG104_RS14300	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KG104_RS14305	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KG104_RS14310	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KG104_RS14315	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KG104_RS14320	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KG104_RS14325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KG104_RS14330	COG0255	Belongs to the universal ribosomal protein uL29 family
KG104_RS14335	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KG104_RS14340	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KG104_RS14345	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KG104_RS14350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KG104_RS14355	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KG104_RS14360	COG0089	rRNA binding
KG104_RS14365	COG0088	Forms part of the polypeptide exit tunnel
KG104_RS14370	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KG104_RS14375	COG0051	transcription antitermination factor activity, RNA binding
KG104_RS14385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KG104_RS14390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KG104_RS14395	COG0049	tRNA binding
KG104_RS14400	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KG104_RS14405	COG1414	Transcriptional regulator
KG104_RS14410	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KG104_RS14420	COG0183	Belongs to the thiolase family
KG104_RS14425	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KG104_RS14440	COG3485	protocatechuate 3,4-dioxygenase
KG104_RS14445	COG3485	protocatechuate 3,4-dioxygenase
KG104_RS14455	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KG104_RS14460	COG0085	RNA polymerase activity
KG104_RS14465	COG0183	Belongs to the thiolase family
KG104_RS14470	COG0222	ribosome binding
KG104_RS14475	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KG104_RS14485	COG0081	regulation of translation
KG104_RS14490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KG104_RS14495	COG0250	Participates in transcription elongation, termination and antitermination
KG104_RS14500	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KG104_RS14510	COG0436	Aminotransferase
KG104_RS14515	COG2197	response regulator
KG104_RS14560	COG3485	protocatechuate 3,4-dioxygenase
KG104_RS14570	COG0745	RESPONSE REGULATOR receiver
KG104_RS14575	COG0456	acetyltransferase
KG104_RS14580	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KG104_RS14590	COG1528	Iron-storage protein
KG104_RS14600	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KG104_RS14605	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KG104_RS14610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KG104_RS14620	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KG104_RS14630	COG2030	dehydratase
KG104_RS14645	COG0693	protein deglycase activity
KG104_RS14655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KG104_RS14665	COG0028	Belongs to the TPP enzyme family
KG104_RS14670	COG0477	Major facilitator Superfamily
KG104_RS14680	COG0531	amino acid
KG104_RS14685	COG1012	belongs to the aldehyde dehydrogenase family
KG104_RS14720	COG2815	serine threonine protein kinase
KG104_RS14720	COG0515	serine threonine protein kinase
KG104_RS14740	COG1228	amidohydrolase
KG104_RS14770	COG1063	alcohol dehydrogenase
KG104_RS14775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KG104_RS14790	COG1666	GTP binding
KG104_RS14800	COG0501	Belongs to the peptidase M48B family
KG104_RS14810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KG104_RS14850	COG1233	COG1233 Phytoene dehydrogenase and related
KG104_RS14860	COG0142	geranyltranstransferase activity
KG104_RS14865	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
KG104_RS14870	COG1215	transferase activity, transferring glycosyl groups
KG104_RS14880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KG104_RS14895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KG104_RS14965	COG1012	belongs to the aldehyde dehydrogenase family
KG104_RS14975	COG3590	peptidase
KG104_RS14995	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KG104_RS15010	COG0535	radical SAM domain protein
KG104_RS15020	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KG104_RS15035	COG2814	Major facilitator Superfamily
KG104_RS15040	COG3284	Transcriptional regulator
KG104_RS15060	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KG104_RS15065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KG104_RS15100	COG0142	geranyltranstransferase activity
KG104_RS15110	COG2226	methyltransferase
KG104_RS15120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KG104_RS15125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KG104_RS15130	COG0765	amino acid transport
KG104_RS15135	COG1126	abc transporter atp-binding protein
KG104_RS15140	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KG104_RS15145	COG0028	Belongs to the TPP enzyme family
KG104_RS15150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KG104_RS15160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KG104_RS15165	COG1113	amino acid transport
KG104_RS15170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KG104_RS15210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KG104_RS15215	COG0730	response to heat
KG104_RS15225	COG1937	Protein conserved in bacteria
KG104_RS15250	COG4948	Mandelate Racemase Muconate Lactonizing
KG104_RS15270	COG0508	dehydrogenase complex catalyzes the overall conversion of
KG104_RS15275	COG0022	dehydrogenase e1 component
KG104_RS15295	COG2837	iron assimilation
KG104_RS15315	COG1024	Enoyl-CoA hydratase
KG104_RS15320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KG104_RS15325	COG2151	metal-sulfur cluster biosynthetic enzyme
KG104_RS15330	COG3396	Phenylacetate-CoA oxygenase
KG104_RS15335	COG3460	Phenylacetate-CoA oxygenase
KG104_RS15340	COG3396	Phenylacetate-CoA oxygenase
KG104_RS15360	COG0586	Pfam SNARE associated Golgi protein
KG104_RS15375	COG1309	transcriptional regulator
KG104_RS15385	COG0477	Major facilitator Superfamily
KG104_RS15390	COG2030	dehydratase
KG104_RS15390	COG1012	belongs to the aldehyde dehydrogenase family
KG104_RS15400	COG1793	dna ligase
KG104_RS15410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KG104_RS15420	COG2365	Tyrosine phosphatase family
KG104_RS15425	COG1250	3-hydroxyacyl-CoA dehydrogenase
KG104_RS15430	COG1024	Enoyl-CoA hydratase
KG104_RS15450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KG104_RS15485	COG1140	nitrate reductase beta subunit
KG104_RS15495	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KG104_RS15520	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KG104_RS15530	COG0785	Cytochrome C biogenesis protein
KG104_RS15540	COG0406	alpha-ribazole phosphatase activity
KG104_RS15545	COG2353	YceI-like domain
KG104_RS15560	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KG104_RS15585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KG104_RS15590	COG0640	Transcriptional regulator
KG104_RS15595	COG0123	including yeast histone deacetylase and acetoin utilization protein
KG104_RS15600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KG104_RS15605	COG0569	domain protein
KG104_RS15615	COG1082	Xylose isomerase domain protein TIM barrel
KG104_RS15620	COG0248	Ppx GppA phosphatase
KG104_RS15625	COG1754	DNA topoisomerase type I activity
KG104_RS15625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KG104_RS15630	COG2890	protein-(glutamine-N5) methyltransferase activity
KG104_RS15635	COG1053	succinate dehydrogenase
KG104_RS15640	COG1960	acyl-CoA dehydrogenase activity
KG104_RS15650	COG1309	transcriptional regulator
KG104_RS15670	COG1012	belongs to the aldehyde dehydrogenase family
KG104_RS15675	COG0477	Major facilitator Superfamily
KG104_RS15680	COG0477	Major facilitator Superfamily
KG104_RS15685	COG2030	dehydratase
KG104_RS15690	COG1054	Belongs to the UPF0176 family
KG104_RS15700	COG1111	helicase
KG104_RS15700	COG1205	dead DEAH box helicase
KG104_RS15755	COG1120	ATPase activity
KG104_RS15770	COG4585	Histidine kinase
KG104_RS15775	COG2197	response regulator
KG104_RS15795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KG104_RS15800	COG1764	response to oxidative stress
KG104_RS15810	COG0477	Major facilitator Superfamily
KG104_RS15815	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KG104_RS15845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KG104_RS15850	COG1408	metallophosphoesterase
KG104_RS15855	COG1132	(ABC) transporter
KG104_RS15860	COG1132	(ABC) transporter
KG104_RS15880	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KG104_RS15885	COG0151	Belongs to the GarS family
KG104_RS15915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KG104_RS15940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KG104_RS15945	COG1012	belongs to the aldehyde dehydrogenase family
KG104_RS15955	COG0768	penicillin binding
KG104_RS15980	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KG104_RS16005	COG1131	(ABC) transporter
KG104_RS16015	COG0789	Transcriptional regulator
KG104_RS16020	COG0484	heat shock protein binding
KG104_RS16025	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KG104_RS16030	COG0443	Heat shock 70 kDa protein
KG104_RS16045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KG104_RS16055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KG104_RS16070	COG1122	ATPase activity
KG104_RS16090	COG2212	antiporter activity
KG104_RS16100	COG0651	ATP synthesis coupled electron transport
KG104_RS16105	COG1006	Multisubunit Na H antiporter MnhC subunit
KG104_RS16110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KG104_RS16110	COG2111	Na H antiporter
KG104_RS16120	COG0717	Belongs to the dCTP deaminase family
KG104_RS16125	COG3483	tryptophan 2,3-dioxygenase activity
KG104_RS16190	COG0776	regulation of translation
KG104_RS16195	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KG104_RS16200	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KG104_RS16205	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KG104_RS16210	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KG104_RS16215	COG1846	Transcriptional regulator
KG104_RS16220	COG0477	Major facilitator Superfamily
KG104_RS16230	COG1597	lipid kinase activity
KG104_RS16245	COG1120	ATPase activity
KG104_RS16250	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KG104_RS16255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KG104_RS16260	COG0435	Glutathione S-transferase
KG104_RS16270	COG0492	ferredoxin-NADP+ reductase activity
KG104_RS16280	COG1295	ribonuclease BN
KG104_RS16300	COG2146	nitrite reductase [NAD(P)H] activity
KG104_RS16320	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS16335	COG1064	alcohol dehydrogenase
KG104_RS16350	COG1414	Transcriptional regulator
KG104_RS16375	COG1473	amidohydrolase
KG104_RS16395	COG4585	Histidine kinase
KG104_RS16400	COG2197	response regulator
KG104_RS16405	COG4152	abc transporter atp-binding protein
KG104_RS16445	COG1012	belongs to the aldehyde dehydrogenase family
KG104_RS16450	COG0583	DNA-binding transcription factor activity
KG104_RS16460	COG0318	PFAM AMP-dependent synthetase and ligase
KG104_RS16475	COG4221	oxidoreductase activity
KG104_RS16485	COG2755	lipolytic protein G-D-S-L family
KG104_RS16505	COG0028	Belongs to the TPP enzyme family
KG104_RS16520	COG1012	belongs to the aldehyde dehydrogenase family
KG104_RS16525	COG2860	membrane
KG104_RS16565	COG1309	transcriptional regulator
KG104_RS16570	COG0577	efflux transmembrane transporter activity
KG104_RS16615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KG104_RS16630	COG2072	flavoprotein involved in K transport
KG104_RS16670	COG3386	PFAM SMP-30 Gluconolaconase
KG104_RS16680	COG2076	Multidrug Resistance protein
KG104_RS16690	COG0531	amino acid
KG104_RS16735	COG0492	ferredoxin-NADP+ reductase activity
KG104_RS16790	COG0577	efflux transmembrane transporter activity
KG104_RS16795	COG0371	Dehydrogenase
KG104_RS16800	COG3559	Exporter of polyketide antibiotics
KG104_RS16805	COG1131	(ABC) transporter
KG104_RS16870	COG2217	Heavy metal translocating P-type atpase
KG104_RS16875	COG0598	Magnesium transport protein CorA
KG104_RS16890	COG0477	Major facilitator Superfamily
KG104_RS16900	COG3546	catalase activity
KG104_RS16905	COG0579	oxidoreductase
KG104_RS16915	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS16935	COG2358	TRAP transporter, solute receptor (TAXI family
KG104_RS16955	COG1028	Short-chain dehydrogenase reductase Sdr
KG104_RS16960	COG2814	Major facilitator Superfamily
KG104_RS16965	COG0589	response to stress
KG104_RS16970	COG0477	Major facilitator Superfamily
KG104_RS16980	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KG104_RS16995	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KG104_RS17000	COG3257	ureidoglycine aminohydrolase activity
KG104_RS17010	COG2233	PERMEase
KG104_RS17035	COG3608	succinylglutamate desuccinylase aspartoacylase
KG104_RS17035	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KG104_RS17045	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KG104_RS17050	COG0277	FAD linked oxidase domain protein
KG104_RS17055	COG1620	l-lactate permease
KG104_RS17060	COG0246	Mannitol dehydrogenase
KG104_RS17065	COG2390	Transcriptional regulator
KG104_RS17075	COG1175	transmembrane transport
KG104_RS17080	COG0395	ABC-type sugar transport system, permease component
KG104_RS17085	COG1115	amino acid carrier protein
KG104_RS17100	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KG104_RS17105	COG0509	glycine decarboxylation via glycine cleavage system
KG104_RS17110	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KG104_RS17115	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KG104_RS17115	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KG104_RS17120	COG1113	amino acid transport
KG104_RS17130	COG2764	glyoxalase bleomycin resistance protein dioxygenase
KG104_RS17165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KG104_RS17215	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KG104_RS17230	COG0686	Belongs to the AlaDH PNT family
KG104_RS17285	COG1802	Transcriptional regulator
KG104_RS17290	COG1250	3-hydroxyacyl-CoA dehydrogenase
KG104_RS17290	COG1024	Enoyl-CoA hydratase
KG104_RS17295	COG2376	Dihydroxyacetone kinase
KG104_RS17300	COG0149	triose-phosphate isomerase activity
KG104_RS17305	COG0698	ribose 5-phosphate isomerase
KG104_RS17310	COG2197	response regulator
KG104_RS17315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KG104_RS17325	COG0508	dehydrogenase complex catalyzes the overall conversion of
KG104_RS17330	COG0022	dehydrogenase e1 component
KG104_RS17340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KG104_RS17345	COG1950	PFAM Membrane protein of
KG104_RS17360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KG104_RS17370	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KG104_RS17380	COG0590	tRNA wobble adenosine to inosine editing
KG104_RS17410	COG2080	2 iron, 2 sulfur cluster binding
KG104_RS17415	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
KG104_RS17420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KG104_RS17470	COG4638	Rieske (2fe-2S)
KG104_RS17475	COG1051	belongs to the nudix hydrolase family
KG104_RS17485	COG0667	Aldo Keto reductase
KG104_RS17490	COG2409	Drug exporters of the RND superfamily
KG104_RS17500	COG0657	acetylesterase activity
KG104_RS17535	COG2814	Major facilitator Superfamily
KG104_RS17580	COG3145	DNA-N1-methyladenine dioxygenase activity
KG104_RS17585	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KG104_RS17585	COG2169	Transcriptional regulator
KG104_RS17590	COG1595	DNA-templated transcription, initiation
KG104_RS17595	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KG104_RS17600	COG0659	secondary active sulfate transmembrane transporter activity
KG104_RS17605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KG104_RS17610	COG1058	Belongs to the CinA family
KG104_RS17610	COG1546	Belongs to the CinA family
KG104_RS17635	COG0318	PFAM AMP-dependent synthetase and ligase
KG104_RS17675	COG0534	Mate efflux family protein
KG104_RS17680	COG2814	Major facilitator Superfamily
KG104_RS17695	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KG104_RS17700	COG1652	LysM domain
KG104_RS17705	COG0531	amino acid
KG104_RS17715	COG0305	Participates in initiation and elongation during chromosome replication
KG104_RS17720	COG0359	binds to the 23S rRNA
KG104_RS17725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KG104_RS17735	COG0360	Binds together with S18 to 16S ribosomal RNA
KG104_RS17740	COG1362	aminopeptidase activity
KG104_RS17750	COG1131	(ABC) transporter
KG104_RS17775	COG0738	Major facilitator superfamily
KG104_RS17780	COG0488	(ABC) transporter
KG104_RS17815	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KG104_RS17820	COG0438	transferase activity, transferring glycosyl groups
KG104_RS17830	COG0406	alpha-ribazole phosphatase activity
KG104_RS17835	COG0617	tRNA 3'-terminal CCA addition
KG104_RS17855	COG0492	ferredoxin-NADP+ reductase activity
KG104_RS17860	COG3118	belongs to the thioredoxin family
KG104_RS17865	COG0860	N-Acetylmuramoyl-L-alanine amidase
KG104_RS17865	COG3409	Peptidoglycan-binding domain 1 protein
KG104_RS17900	COG1475	DNA binding
KG104_RS17905	COG1192	Involved in chromosome partitioning
KG104_RS17910	COG0357	Ribosomal RNA small subunit methyltransferase G
KG104_RS17920	COG0706	membrane insertase activity
KG104_RS17930	COG0594	ribonuclease P activity
KG104_RS17935	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KG104_RS18030	COG1388	LysM domain
KG104_RS18075	COG2072	flavoprotein involved in K transport
KG104_RS18090	COG0584	glycerophosphoryl diester phosphodiesterase
KG104_RS18105	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KG104_RS18160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KG104_RS18175	COG0739	heme binding
KG104_RS18175	COG0741	lytic transglycosylase activity
KG104_RS18175	COG1196	nuclear chromosome segregation