locus-tag	class	description
AP9108_RS00015	COG1216	Glycosyl transferase, family 2
AP9108_RS00015	COG0463	Glycosyl transferase, family 2
AP9108_RS00175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AP9108_RS00205	COG1797	cobyrinic acid a,c-diamide synthase activity
AP9108_RS00230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AP9108_RS00230	COG0237	dephospho-CoA kinase activity
AP9108_RS00235	COG0586	Pfam SNARE associated Golgi protein
AP9108_RS00240	COG1366	Belongs to the anti-sigma-factor antagonist family
AP9108_RS00260	COG1619	proteins homologs of microcin C7 resistance protein MccF
AP9108_RS00285	COG1489	DNA binding
AP9108_RS00330	COG0037	tRNA processing
AP9108_RS00335	COG0463	Glycosyl transferase, family 2
AP9108_RS00345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AP9108_RS00355	COG0745	RESPONSE REGULATOR receiver
AP9108_RS00360	COG3411	Ferredoxin
AP9108_RS00365	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AP9108_RS00370	COG0459	protein refolding
AP9108_RS00380	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AP9108_RS00395	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AP9108_RS00400	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AP9108_RS00415	COG0242	peptide deformylase activity
AP9108_RS00440	COG1836	PFAM Integral membrane protein DUF92
AP9108_RS00485	COG0357	Ribosomal RNA small subunit methyltransferase G
AP9108_RS00500	COG0616	signal peptide processing
AP9108_RS00505	COG0697	spore germination
AP9108_RS00520	COG2003	Belongs to the UPF0758 family
AP9108_RS00555	COG1741	Belongs to the pirin family
AP9108_RS00570	COG0500	methyltransferase
AP9108_RS00575	COG2226	methyltransferase
AP9108_RS00580	COG1280	lysine exporter protein (LysE YggA)
AP9108_RS00585	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AP9108_RS00600	COG0826	peptidase U32
AP9108_RS00610	COG4221	oxidoreductase activity
AP9108_RS00615	COG0156	8-amino-7-oxononanoate synthase activity
AP9108_RS00625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AP9108_RS00630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AP9108_RS00640	COG0484	heat shock protein binding
AP9108_RS00655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AP9108_RS00685	COG0529	Catalyzes the synthesis of activated sulfate
AP9108_RS00700	COG0438	transferase activity, transferring glycosyl groups
AP9108_RS00725	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AP9108_RS00730	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AP9108_RS00750	COG1271	oxidase subunit
AP9108_RS00770	COG0300	oxidoreductase activity
AP9108_RS00770	COG3000	fatty acid hydroxylase
AP9108_RS00785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AP9108_RS00790	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AP9108_RS00815	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AP9108_RS00820	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AP9108_RS00830	COG0514	ATP-dependent DNA helicase (RecQ)
AP9108_RS00840	COG0514	ATP-dependent DNA helicase (RecQ)
AP9108_RS00865	COG4251	negative regulation of phosphorylation
AP9108_RS00890	COG0668	transmembrane transport
AP9108_RS01040	COG2912	Transglutaminase-like superfamily
AP9108_RS01100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AP9108_RS01190	COG0009	L-threonylcarbamoyladenylate synthase
AP9108_RS01200	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AP9108_RS01215	COG1376	ErfK ybiS ycfS ynhG family protein
AP9108_RS01225	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AP9108_RS01230	COG1472	Belongs to the glycosyl hydrolase 3 family
AP9108_RS01240	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AP9108_RS01265	COG1361	Conserved repeat domain
AP9108_RS01265	COG3266	domain, Protein
AP9108_RS01265	COG2911	Protein conserved in bacteria
AP9108_RS01270	COG0793	Belongs to the peptidase S41A family
AP9108_RS01280	COG0745	RESPONSE REGULATOR receiver
AP9108_RS01285	COG0730	response to heat
AP9108_RS01295	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AP9108_RS01295	COG3264	Mechanosensitive ion channel
AP9108_RS01320	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AP9108_RS01330	COG0017	Asparaginyl-tRNA synthetase
AP9108_RS01395	COG0105	UTP biosynthetic process
AP9108_RS01400	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AP9108_RS01435	COG3852	Histidine kinase
AP9108_RS01450	COG0297	glycogen (starch) synthase activity
AP9108_RS01460	COG3852	Histidine kinase
AP9108_RS01465	COG0702	epimerase
AP9108_RS01470	COG0330	HflC and HflK could
AP9108_RS01490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AP9108_RS01495	COG1032	radical SAM domain protein
AP9108_RS01500	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AP9108_RS01515	COG0270	DNA (cytosine-5-)-methyltransferase activity
AP9108_RS01540	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AP9108_RS01550	COG3063	Type IV pilus biogenesis stability protein PilW
AP9108_RS01565	COG0222	ribosome binding
AP9108_RS01570	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AP9108_RS01575	COG0081	regulation of translation
AP9108_RS01580	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AP9108_RS01585	COG0250	Participates in transcription elongation, termination and antitermination
AP9108_RS01590	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AP9108_RS01600	COG0335	large ribosomal subunit rRNA binding
AP9108_RS01605	COG0752	glycyl-tRNA synthetase alpha subunit
AP9108_RS01625	COG2205	protein histidine kinase activity
AP9108_RS01635	COG0494	nUDIX hydrolase
AP9108_RS01640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AP9108_RS01650	COG0601	transmembrane transport
AP9108_RS01655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AP9108_RS01780	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AP9108_RS01785	COG3932	Exopolysaccharide synthesis, ExoD
AP9108_RS01800	COG0284	orotidine-5'-phosphate decarboxylase activity
AP9108_RS01800	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AP9108_RS01815	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AP9108_RS01820	COG1882	Formate acetyltransferase
AP9108_RS01825	COG0537	adenosine 5'-monophosphoramidase activity
AP9108_RS01855	COG1695	Transcriptional regulator
AP9108_RS01860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AP9108_RS01870	COG2119	membrane
AP9108_RS01880	COG1640	4-alpha-glucanotransferase
AP9108_RS01885	COG1426	Protein conserved in bacteria
AP9108_RS01890	COG1187	pseudouridine synthase activity
AP9108_RS01910	COG1982	Orn Lys Arg decarboxylase major
AP9108_RS01915	COG0012	GTP binding
AP9108_RS01920	COG1950	PFAM Membrane protein of
AP9108_RS01935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AP9108_RS01940	COG0306	phosphate transporter
AP9108_RS01955	COG0464	growth
AP9108_RS02050	COG1598	PFAM Uncharacterised protein family UPF0150
AP9108_RS02075	COG2886	Uncharacterised protein family (UPF0175)
AP9108_RS02125	COG1598	PFAM Uncharacterised protein family UPF0150
AP9108_RS02170	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AP9108_RS02210	COG2027	D-alanyl-D-alanine carboxypeptidase
AP9108_RS02215	COG2045	Belongs to the ComB family
AP9108_RS02220	COG4249	Peptidase C14 caspase catalytic subunit p20
AP9108_RS02220	COG2319	Wd-40 repeat
AP9108_RS02230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AP9108_RS02370	COG0768	penicillin binding
AP9108_RS02380	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AP9108_RS02410	COG0754	glutathionylspermidine amidase activity
AP9108_RS02465	COG0598	Magnesium transport protein CorA
AP9108_RS02470	COG0515	serine threonine protein kinase
AP9108_RS02470	COG3266	domain, Protein
AP9108_RS02475	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AP9108_RS02525	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AP9108_RS02590	COG0515	serine threonine protein kinase
AP9108_RS02590	COG1357	PFAM Pentapeptide repeats (8 copies)
AP9108_RS02600	COG1181	Belongs to the D-alanine--D-alanine ligase family
AP9108_RS02615	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
AP9108_RS02745	COG2203	Gaf domain
AP9108_RS02745	COG3706	GGDEF domain
AP9108_RS02745	COG4251	negative regulation of phosphorylation
AP9108_RS02745	COG5001	Diguanylate cyclase
AP9108_RS02755	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AP9108_RS02765	COG3937	granule-associated protein
AP9108_RS02770	COG0489	protein tyrosine kinase activity
AP9108_RS02780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AP9108_RS02800	COG0271	Belongs to the BolA IbaG family
AP9108_RS02805	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AP9108_RS02815	COG0745	RESPONSE REGULATOR receiver
AP9108_RS02820	COG1012	belongs to the aldehyde dehydrogenase family
AP9108_RS02845	COG0643	Histidine kinase
AP9108_RS02845	COG2198	Histidine kinase
AP9108_RS02845	COG0784	Response regulator, receiver
AP9108_RS02850	COG5002	protein histidine kinase activity
AP9108_RS02880	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AP9108_RS02910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AP9108_RS02930	COG1295	ribonuclease BN
AP9108_RS02940	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AP9108_RS02960	COG0277	FAD linked oxidase domain protein
AP9108_RS02965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AP9108_RS02980	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AP9108_RS02995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AP9108_RS03000	COG3659	wide pore channel activity
AP9108_RS03005	COG3659	wide pore channel activity
AP9108_RS03010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AP9108_RS03035	COG2046	Belongs to the sulfate adenylyltransferase family
AP9108_RS03165	COG0784	Response regulator, receiver
AP9108_RS03165	COG2205	protein histidine kinase activity
AP9108_RS03190	COG4191	Histidine kinase
AP9108_RS03225	COG0242	peptide deformylase activity
AP9108_RS03230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AP9108_RS03235	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AP9108_RS03240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AP9108_RS03280	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AP9108_RS03290	COG2084	Dehydrogenase
AP9108_RS03310	COG0316	Belongs to the HesB IscA family
AP9108_RS03330	COG0463	Glycosyl transferase, family 2
AP9108_RS03335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AP9108_RS03345	COG1136	(ABC) transporter
AP9108_RS03355	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AP9108_RS03370	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AP9108_RS03380	COG5002	protein histidine kinase activity
AP9108_RS03385	COG0745	RESPONSE REGULATOR receiver
AP9108_RS03415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AP9108_RS03425	COG3239	Fatty acid desaturase
AP9108_RS03440	COG2226	methyltransferase
AP9108_RS03490	COG0772	Belongs to the SEDS family
AP9108_RS03505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AP9108_RS03515	COG0793	Belongs to the peptidase S41A family
AP9108_RS03520	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AP9108_RS03545	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AP9108_RS03555	COG1446	asparaginase
AP9108_RS03560	COG0745	RESPONSE REGULATOR receiver
AP9108_RS03565	COG0643	Histidine kinase
AP9108_RS03565	COG2198	Histidine kinase
AP9108_RS03575	COG0840	transmembrane signaling receptor activity
AP9108_RS03585	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AP9108_RS03585	COG0457	Tetratricopeptide repeat
AP9108_RS03590	COG2201	protein-glutamate methylesterase activity
AP9108_RS03600	COG0863	Belongs to the N(4) N(6)-methyltransferase family
AP9108_RS03615	COG1333	cytochrome c biogenesis protein
AP9108_RS03650	COG0768	penicillin binding
AP9108_RS03665	COG4095	Psort location CytoplasmicMembrane, score
AP9108_RS03690	COG4447	cellulose binding
AP9108_RS03695	COG1773	rubredoxin
AP9108_RS03705	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AP9108_RS03710	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AP9108_RS03715	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AP9108_RS03725	COG0612	Peptidase, M16
AP9108_RS03735	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AP9108_RS03740	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AP9108_RS03745	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AP9108_RS03755	COG4251	negative regulation of phosphorylation
AP9108_RS03770	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AP9108_RS03775	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AP9108_RS03780	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AP9108_RS03785	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AP9108_RS03790	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AP9108_RS03795	COG0356	it plays a direct role in the translocation of protons across the membrane
AP9108_RS03805	COG0442	prolyl-tRNA aminoacylation
AP9108_RS03810	COG1555	photosystem II stabilization
AP9108_RS03810	COG1596	polysaccharide export
AP9108_RS03820	COG1104	cysteine desulfurase activity
AP9108_RS03825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AP9108_RS03830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AP9108_RS03830	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AP9108_RS03935	COG4636	protein conserved in cyanobacteria
AP9108_RS03940	COG4636	protein conserved in cyanobacteria
AP9108_RS04335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AP9108_RS04340	COG0735	belongs to the Fur family
AP9108_RS04345	COG0860	N-Acetylmuramoyl-L-alanine amidase
AP9108_RS04345	COG3409	Peptidoglycan-binding domain 1 protein
AP9108_RS04360	COG0673	inositol 2-dehydrogenase activity
AP9108_RS04370	COG2385	sporulation resulting in formation of a cellular spore
AP9108_RS04380	COG0574	Belongs to the PEP-utilizing enzyme family
AP9108_RS04380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AP9108_RS04385	COG1733	regulation of RNA biosynthetic process
AP9108_RS04415	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AP9108_RS04415	COG0617	tRNA 3'-terminal CCA addition
AP9108_RS04415	COG0517	IMP dehydrogenase activity
AP9108_RS04475	COG0438	transferase activity, transferring glycosyl groups
AP9108_RS04480	COG1215	transferase activity, transferring glycosyl groups
AP9108_RS04510	COG1131	(ABC) transporter
AP9108_RS04515	COG0745	RESPONSE REGULATOR receiver
AP9108_RS04555	COG0302	gtp cyclohydrolase
AP9108_RS04565	COG0523	cobalamin synthesis protein
AP9108_RS04610	COG0659	secondary active sulfate transmembrane transporter activity
AP9108_RS04615	COG0659	secondary active sulfate transmembrane transporter activity
AP9108_RS04620	COG1175	transmembrane transport
AP9108_RS04635	COG0402	S-adenosylhomocysteine deaminase activity
AP9108_RS04645	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AP9108_RS04650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AP9108_RS04655	COG2226	methyltransferase
AP9108_RS04680	COG3903	Transcriptional regulator
AP9108_RS04680	COG2319	Wd-40 repeat
AP9108_RS04695	COG0589	response to stress
AP9108_RS04700	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
AP9108_RS04710	COG1217	gtp-binding protein TYPA
AP9108_RS04720	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AP9108_RS04730	COG1555	photosystem II stabilization
AP9108_RS04740	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AP9108_RS04780	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AP9108_RS04790	COG1840	ABC-type Fe3 transport system, periplasmic component
AP9108_RS04800	COG3659	wide pore channel activity
AP9108_RS04810	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AP9108_RS04815	COG0114	fumarate hydratase activity
AP9108_RS04875	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AP9108_RS04880	COG0824	Thioesterase
AP9108_RS04900	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AP9108_RS04915	COG0745	RESPONSE REGULATOR receiver
AP9108_RS04935	COG0006	proline dipeptidase activity
AP9108_RS04940	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AP9108_RS04945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AP9108_RS04950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AP9108_RS04955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AP9108_RS04975	COG2124	cytochrome p450
AP9108_RS04980	COG1575	Belongs to the MenA family. Type 1 subfamily
AP9108_RS04995	COG0732	type I restriction modification DNA specificity domain
AP9108_RS05035	COG3266	domain, Protein
AP9108_RS05035	COG1361	Conserved repeat domain
AP9108_RS05035	COG2911	Protein conserved in bacteria
AP9108_RS05065	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AP9108_RS05070	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AP9108_RS05080	COG1131	(ABC) transporter
AP9108_RS05100	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AP9108_RS05105	COG0189	ligase activity
AP9108_RS05120	COG0440	acetolactate synthase activity
AP9108_RS05125	COG0475	glutathione-regulated potassium exporter activity
AP9108_RS05145	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AP9108_RS05155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AP9108_RS05180	COG0784	Response regulator, receiver
AP9108_RS05180	COG2205	protein histidine kinase activity
AP9108_RS05190	COG0588	phosphoglycerate mutase activity
AP9108_RS05195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AP9108_RS05210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AP9108_RS05215	COG0552	protein localization to endoplasmic reticulum
AP9108_RS05215	COG0552	protein localization to endoplasmic reticulum
AP9108_RS05220	COG2208	phosphoserine phosphatase activity
AP9108_RS05230	COG0165	Argininosuccinate lyase
AP9108_RS05295	COG0484	heat shock protein binding
AP9108_RS05300	COG0443	Heat shock 70 kDa protein
AP9108_RS05305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AP9108_RS05305	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AP9108_RS05320	COG0513	Belongs to the DEAD box helicase family
AP9108_RS05345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AP9108_RS05380	COG0724	RNA recognition motif
AP9108_RS05390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AP9108_RS05430	COG1122	ATPase activity
AP9108_RS05460	COG0772	Belongs to the SEDS family
AP9108_RS05470	COG0768	penicillin binding
AP9108_RS05500	COG1115	amino acid carrier protein
AP9108_RS05505	COG0107	imidazoleglycerol-phosphate synthase activity
AP9108_RS05660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AP9108_RS05670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AP9108_RS05680	COG0686	Belongs to the AlaDH PNT family
AP9108_RS05690	COG1040	competence protein
AP9108_RS05830	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AP9108_RS05860	COG1215	transferase activity, transferring glycosyl groups
AP9108_RS05865	COG0515	serine threonine protein kinase
AP9108_RS05865	COG2815	serine threonine protein kinase
AP9108_RS05870	COG3852	Histidine kinase
AP9108_RS05875	COG2814	Major facilitator Superfamily
AP9108_RS05880	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AP9108_RS05880	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AP9108_RS05885	COG0339	signal peptide processing
AP9108_RS05930	COG0308	aminopeptidase N
AP9108_RS05935	COG0436	Aminotransferase
AP9108_RS05940	COG1254	Belongs to the acylphosphatase family
AP9108_RS05960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AP9108_RS05995	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AP9108_RS06010	COG0792	nuclease activity
AP9108_RS06020	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AP9108_RS06025	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AP9108_RS06035	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AP9108_RS06050	COG0840	transmembrane signaling receptor activity
AP9108_RS06055	COG1073	alpha beta
AP9108_RS06120	COG4372	Transposase
AP9108_RS06125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AP9108_RS06130	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AP9108_RS06135	COG0131	Imidazoleglycerol-phosphate dehydratase
AP9108_RS06140	COG0793	Belongs to the peptidase S41A family
AP9108_RS06150	COG0793	Belongs to the peptidase S41A family
AP9108_RS06160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AP9108_RS06160	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AP9108_RS06185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AP9108_RS06255	COG4968	Prepilin-type N-terminal cleavage methylation domain
AP9108_RS06310	COG1252	NADH dehydrogenase
AP9108_RS06315	COG0315	cyclic pyranopterin monophosphate synthase activity
AP9108_RS06325	COG3848	Pyruvate phosphate dikinase
AP9108_RS06325	COG0574	Belongs to the PEP-utilizing enzyme family
AP9108_RS06340	COG0318	PFAM AMP-dependent synthetase and ligase
AP9108_RS06355	COG0728	peptidoglycan biosynthetic process
AP9108_RS06390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AP9108_RS06395	COG0110	maltose O-acetyltransferase activity
AP9108_RS06400	COG0010	Belongs to the arginase family
AP9108_RS06410	COG0528	UMP kinase activity
AP9108_RS06415	COG0233	cytoplasmic translational termination
AP9108_RS06425	COG5001	Diguanylate cyclase
AP9108_RS06425	COG4251	negative regulation of phosphorylation
AP9108_RS06425	COG3706	GGDEF domain
AP9108_RS06425	COG2203	Gaf domain
AP9108_RS06430	COG2010	Cytochrome c
AP9108_RS06435	COG0312	modulator of DNA gyrase
AP9108_RS06460	COG0489	protein tyrosine kinase activity
AP9108_RS06480	COG1049	propionate catabolic process, 2-methylcitrate cycle
AP9108_RS06535	COG1192	Involved in chromosome partitioning
AP9108_RS06560	COG2197	response regulator
AP9108_RS06575	COG1475	DNA binding
AP9108_RS06700	COG1253	flavin adenine dinucleotide binding
AP9108_RS06705	COG1803	Methylglyoxal synthase
AP9108_RS06705	COG1597	lipid kinase activity
AP9108_RS06710	COG2217	Heavy metal translocating P-type atpase
AP9108_RS06755	COG0542	response to heat
AP9108_RS06765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AP9108_RS06770	COG3659	wide pore channel activity
AP9108_RS06815	COG0129	dihydroxy-acid dehydratase activity
AP9108_RS06845	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AP9108_RS06855	COG0419	ATPase involved in DNA repair
AP9108_RS06870	COG1032	radical SAM domain protein
AP9108_RS06875	COG0156	8-amino-7-oxononanoate synthase activity
AP9108_RS06895	COG0318	PFAM AMP-dependent synthetase and ligase
AP9108_RS06910	COG0047	phosphoribosylformylglycinamidine synthase activity
AP9108_RS06915	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AP9108_RS06920	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AP9108_RS06975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP9108_RS07095	COG1459	type II secretion system
AP9108_RS07105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AP9108_RS07110	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AP9108_RS07115	COG0443	Heat shock 70 kDa protein
AP9108_RS07120	COG0484	heat shock protein binding
AP9108_RS07130	COG1162	GTPase activity
AP9108_RS07145	COG2223	nitrite transmembrane transporter activity
AP9108_RS07155	COG0402	S-adenosylhomocysteine deaminase activity
AP9108_RS07160	COG1596	polysaccharide export
AP9108_RS07185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AP9108_RS07210	COG1028	Short-chain dehydrogenase reductase Sdr
AP9108_RS07220	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AP9108_RS07240	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AP9108_RS07370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AP9108_RS07375	COG0719	Fe-S assembly protein
AP9108_RS07380	COG0396	ATPase activity
AP9108_RS07385	COG0719	Fe-S assembly protein
AP9108_RS07400	COG2255	four-way junction helicase activity
AP9108_RS07480	COG0460	homoserine dehydrogenase
AP9108_RS07485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AP9108_RS07500	COG1295	ribonuclease BN
AP9108_RS07520	COG0803	Belongs to the bacterial solute-binding protein 9 family
AP9108_RS07530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AP9108_RS07575	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AP9108_RS07580	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AP9108_RS07585	COG0019	diaminopimelate decarboxylase activity
AP9108_RS07595	COG0542	response to heat
AP9108_RS07605	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AP9108_RS07610	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AP9108_RS07615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AP9108_RS07625	COG5002	protein histidine kinase activity
AP9108_RS07650	COG1473	amidohydrolase
AP9108_RS07665	COG0601	transmembrane transport
AP9108_RS07670	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AP9108_RS07690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AP9108_RS07705	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AP9108_RS07715	COG0521	Mo-molybdopterin cofactor biosynthetic process
AP9108_RS07720	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AP9108_RS07725	COG2154	pterin-4-alpha-carbinolamine dehydratase
AP9108_RS07730	COG2340	Cysteine-rich secretory protein family
AP9108_RS07740	COG2890	protein-(glutamine-N5) methyltransferase activity
AP9108_RS07790	COG1260	myo-inositol-1-phosphate synthase
AP9108_RS07960	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AP9108_RS07965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AP9108_RS07970	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AP9108_RS07975	COG0395	ABC-type sugar transport system, permease component
AP9108_RS08010	COG0408	coproporphyrinogen oxidase activity
AP9108_RS08045	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AP9108_RS08055	COG1842	Phage shock protein A
AP9108_RS08070	COG2197	response regulator
AP9108_RS08115	COG0842	Transport permease protein
AP9108_RS08115	COG1716	ATPase activity
AP9108_RS08115	COG1131	(ABC) transporter
AP9108_RS08130	COG1215	transferase activity, transferring glycosyl groups
AP9108_RS08140	COG0110	maltose O-acetyltransferase activity
AP9108_RS08235	COG0642	Histidine kinase
AP9108_RS08245	COG1725	Transcriptional regulator
AP9108_RS08250	COG0412	Dienelactone hydrolase
AP9108_RS08255	COG0539	negative regulation of cytoplasmic translation
AP9108_RS08260	COG2971	BadF BadG BcrA BcrD
AP9108_RS08275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AP9108_RS08295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AP9108_RS08355	COG0515	serine threonine protein kinase
AP9108_RS08355	COG3266	domain, Protein
AP9108_RS08410	COG0542	response to heat
AP9108_RS08435	COG5002	protein histidine kinase activity
AP9108_RS08455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AP9108_RS08455	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AP9108_RS08480	COG2217	Heavy metal translocating P-type atpase
AP9108_RS08490	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AP9108_RS08505	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AP9108_RS08510	COG0237	dephospho-CoA kinase activity
AP9108_RS08540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AP9108_RS08545	COG0629	single-stranded DNA binding
AP9108_RS08550	COG5002	protein histidine kinase activity
AP9108_RS08575	COG0745	RESPONSE REGULATOR receiver
AP9108_RS08585	COG0321	lipoyl(octanoyl) transferase activity
AP9108_RS08640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AP9108_RS08695	COG2192	nodulation
AP9108_RS08720	COG0277	FAD linked oxidase domain protein
AP9108_RS08720	COG0247	lactate metabolic process
AP9108_RS08730	COG0740	serine-type endopeptidase activity
AP9108_RS08740	COG0557	exoribonuclease II activity
AP9108_RS08800	COG0776	regulation of translation
AP9108_RS08810	COG1429	ligase activity, forming nitrogen-metal bonds
AP9108_RS08815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AP9108_RS08820	COG0569	domain protein
AP9108_RS08855	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AP9108_RS08860	COG1361	Conserved repeat domain
AP9108_RS08860	COG2911	Protein conserved in bacteria
AP9108_RS08860	COG3266	domain, Protein
AP9108_RS08880	COG1216	Glycosyl transferase, family 2
AP9108_RS08880	COG0463	Glycosyl transferase, family 2
AP9108_RS08920	COG0438	transferase activity, transferring glycosyl groups
AP9108_RS08935	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AP9108_RS09105	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AP9108_RS09110	COG0375	protein maturation
AP9108_RS09115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AP9108_RS09125	COG0205	6-phosphofructokinase activity
AP9108_RS09135	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AP9108_RS09205	COG1702	phosphate starvation-inducible protein PhoH
AP9108_RS09210	COG1837	Belongs to the UPF0109 family
AP9108_RS09215	COG0228	four-way junction DNA binding
AP9108_RS09270	COG1122	ATPase activity
AP9108_RS09350	COG0517	IMP dehydrogenase activity
AP9108_RS09350	COG0516	GMP reductase activity
AP9108_RS09365	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AP9108_RS09385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AP9108_RS09400	COG0215	cysteine-tRNA ligase activity
AP9108_RS09410	COG0523	cobalamin synthesis protein
AP9108_RS09415	COG2166	iron-sulfur cluster assembly
AP9108_RS09420	COG0113	porphobilinogen synthase activity
AP9108_RS09440	COG0004	ammonium transporteR
AP9108_RS09450	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AP9108_RS09465	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AP9108_RS09500	COG0596	Alpha beta hydrolase
AP9108_RS09510	COG0538	isocitrate dehydrogenase activity
AP9108_RS09515	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AP9108_RS09525	COG0303	'Molybdopterin
AP9108_RS09535	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AP9108_RS09555	COG2205	protein histidine kinase activity
AP9108_RS09555	COG0784	Response regulator, receiver
AP9108_RS09555	COG2198	Histidine kinase
AP9108_RS09565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AP9108_RS09575	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AP9108_RS09590	COG0512	Glutamine amidotransferase of anthranilate synthase
AP9108_RS09590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AP9108_RS09595	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AP9108_RS09600	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AP9108_RS09795	COG0617	tRNA 3'-terminal CCA addition
AP9108_RS09850	COG0515	serine threonine protein kinase
AP9108_RS09850	COG1357	PFAM Pentapeptide repeats (8 copies)
AP9108_RS09925	COG1214	PFAM Peptidase M22, glycoprotease
AP9108_RS09960	COG3409	Peptidoglycan-binding domain 1 protein
AP9108_RS09985	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AP9108_RS09985	COG0189	ligase activity
AP9108_RS09990	COG4242	Belongs to the peptidase S51 family
AP9108_RS10000	COG0336	Belongs to the RNA methyltransferase TrmD family
AP9108_RS10020	COG0589	response to stress
AP9108_RS10020	COG0475	glutathione-regulated potassium exporter activity
AP9108_RS10095	COG0415	Belongs to the DNA photolyase family
AP9108_RS10110	COG1215	transferase activity, transferring glycosyl groups
AP9108_RS10120	COG0857	belongs to the CobB CobQ family
AP9108_RS10260	COG1191	sigma factor activity
AP9108_RS10265	COG0509	glycine decarboxylation via glycine cleavage system
AP9108_RS10300	COG0596	Alpha beta hydrolase
AP9108_RS10315	COG2885	chlorophyll binding
AP9108_RS10320	COG2885	chlorophyll binding
AP9108_RS10325	COG0307	riboflavin synthase, alpha
AP9108_RS10335	COG0667	Aldo Keto reductase
AP9108_RS10350	COG0515	serine threonine protein kinase
AP9108_RS10355	COG0583	DNA-binding transcription factor activity
AP9108_RS10360	COG0583	DNA-binding transcription factor activity
AP9108_RS10370	COG3118	belongs to the thioredoxin family
AP9108_RS10380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AP9108_RS10385	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AP9108_RS10390	COG0328	RNA-DNA hybrid ribonuclease activity
AP9108_RS10395	COG0138	bifunctional purine biosynthesis protein purh
AP9108_RS10405	COG0745	RESPONSE REGULATOR receiver
AP9108_RS10415	COG0471	metal ion transport
AP9108_RS10415	COG3273	potassium ion transport
AP9108_RS10420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AP9108_RS10435	COG0463	Glycosyl transferase, family 2
AP9108_RS10475	COG2850	peptidyl-arginine hydroxylation
AP9108_RS10495	COG5002	protein histidine kinase activity
AP9108_RS10510	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AP9108_RS10515	COG0088	Forms part of the polypeptide exit tunnel
AP9108_RS10520	COG0089	rRNA binding
AP9108_RS10525	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AP9108_RS10530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AP9108_RS10540	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AP9108_RS10545	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AP9108_RS10550	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AP9108_RS10555	COG0255	Belongs to the universal ribosomal protein uL29 family
AP9108_RS10560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AP9108_RS10565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AP9108_RS10570	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AP9108_RS10575	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AP9108_RS10580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AP9108_RS10590	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AP9108_RS10595	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AP9108_RS10600	COG0200	Binds to the 23S rRNA
AP9108_RS10605	COG0201	protein transport
AP9108_RS10610	COG0563	adenylate kinase activity
AP9108_RS10615	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AP9108_RS10620	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AP9108_RS10625	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AP9108_RS10630	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AP9108_RS10635	COG0202	RNA polymerase activity
AP9108_RS10640	COG0203	ribosomal protein L17
AP9108_RS10645	COG0101	tRNA pseudouridine synthase activity
AP9108_RS10650	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AP9108_RS10655	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AP9108_RS10660	COG0254	rRNA binding
AP9108_RS10680	COG2204	response regulator
AP9108_RS10685	COG0488	(ABC) transporter
AP9108_RS10715	COG0484	heat shock protein binding
AP9108_RS10725	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AP9108_RS10740	COG2226	methyltransferase
AP9108_RS10750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AP9108_RS10750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AP9108_RS10755	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AP9108_RS10760	COG2211	Major facilitator Superfamily
AP9108_RS10770	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AP9108_RS10790	COG1404	Belongs to the peptidase S8 family
AP9108_RS10800	COG2319	Wd-40 repeat
AP9108_RS10800	COG3903	Transcriptional regulator
AP9108_RS10850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AP9108_RS10865	COG5002	protein histidine kinase activity
AP9108_RS10875	COG0745	RESPONSE REGULATOR receiver
AP9108_RS10890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AP9108_RS10900	COG1196	nuclear chromosome segregation
AP9108_RS10940	COG0134	indole-3-glycerol-phosphate synthase activity
AP9108_RS10955	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AP9108_RS10960	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AP9108_RS10970	COG0148	phosphopyruvate hydratase activity
AP9108_RS10975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AP9108_RS10995	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AP9108_RS11020	COG0589	response to stress
AP9108_RS11030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AP9108_RS11035	COG2066	Belongs to the glutaminase family
AP9108_RS11125	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AP9108_RS11130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AP9108_RS11210	COG1666	GTP binding
AP9108_RS11505	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AP9108_RS11510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AP9108_RS11520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AP9108_RS11535	COG2066	Belongs to the glutaminase family
AP9108_RS11590	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AP9108_RS11640	COG3536	Protein conserved in bacteria
AP9108_RS11645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AP9108_RS11655	COG0644	oxidoreductase
AP9108_RS11675	COG1045	serine acetyltransferase
AP9108_RS11885	COG0840	transmembrane signaling receptor activity
AP9108_RS11890	COG2198	Histidine kinase
AP9108_RS11890	COG0784	Response regulator, receiver
AP9108_RS11890	COG0643	Histidine kinase
AP9108_RS11950	COG5001	Diguanylate cyclase
AP9108_RS11950	COG2203	Gaf domain
AP9108_RS11950	COG3706	GGDEF domain
AP9108_RS11950	COG4251	negative regulation of phosphorylation
AP9108_RS11985	COG1943	Transposase
AP9108_RS12000	COG0424	maF-like protein
AP9108_RS12030	COG0154	amidase activity
AP9108_RS12040	COG1127	ABC transporter
AP9108_RS12045	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AP9108_RS12055	COG3409	Peptidoglycan-binding domain 1 protein
AP9108_RS12075	COG0848	biopolymer transport protein
AP9108_RS12095	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AP9108_RS12130	COG0724	RNA recognition motif
AP9108_RS12145	COG0737	Belongs to the 5'-nucleotidase family
AP9108_RS12150	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AP9108_RS12155	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AP9108_RS12170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AP9108_RS12180	COG0483	inositol monophosphate 1-phosphatase activity
AP9108_RS12190	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AP9108_RS12195	COG0436	Aminotransferase
AP9108_RS12200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AP9108_RS12200	COG3266	domain, Protein
AP9108_RS12210	COG0195	Participates in both transcription termination and antitermination
AP9108_RS12215	COG0779	Required for maturation of 30S ribosomal subunits
AP9108_RS12225	COG1216	Glycosyl transferase, family 2
AP9108_RS12230	COG0360	Binds together with S18 to 16S ribosomal RNA
AP9108_RS12245	COG1776	CheC inhibitor of MCP methylation
AP9108_RS12250	COG2201	protein-glutamate methylesterase activity
AP9108_RS12260	COG0446	pyridine nucleotide-disulphide oxidoreductase
AP9108_RS12265	COG0579	oxidoreductase
AP9108_RS12275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AP9108_RS12280	COG1121	(ABC) transporter
AP9108_RS12290	COG0557	exoribonuclease II activity
AP9108_RS12295	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AP9108_RS12300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AP9108_RS12335	COG0436	Aminotransferase
AP9108_RS12340	COG3118	belongs to the thioredoxin family
AP9108_RS12350	COG1494	fructose-1,6-bisphosphatase
AP9108_RS12355	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AP9108_RS12360	COG0525	valine-tRNA ligase activity
AP9108_RS12380	COG1672	PFAM Archaeal ATPase
AP9108_RS12380	COG2319	Wd-40 repeat
AP9108_RS12385	COG0009	L-threonylcarbamoyladenylate synthase
AP9108_RS12390	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AP9108_RS12395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AP9108_RS12400	COG1850	ribulose-bisphosphate carboxylase activity
AP9108_RS12405	COG0235	Class ii aldolase
AP9108_RS12420	COG0789	Transcriptional regulator
AP9108_RS12425	COG2082	Precorrin-8x methylmutase
AP9108_RS12435	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AP9108_RS12455	COG0444	Belongs to the ABC transporter superfamily
AP9108_RS12460	COG4608	Belongs to the ABC transporter superfamily
AP9108_RS12475	COG0657	acetylesterase activity
AP9108_RS12495	COG2949	membrane
AP9108_RS12505	COG0157	Belongs to the NadC ModD family
AP9108_RS12515	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AP9108_RS12520	COG1216	Glycosyl transferase, family 2
AP9108_RS12530	COG1132	(ABC) transporter
AP9108_RS12540	COG0438	transferase activity, transferring glycosyl groups
AP9108_RS12555	COG0438	transferase activity, transferring glycosyl groups
AP9108_RS12565	COG1216	Glycosyl transferase, family 2
AP9108_RS12575	COG0438	transferase activity, transferring glycosyl groups
AP9108_RS12580	COG0438	transferase activity, transferring glycosyl groups
AP9108_RS12610	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AP9108_RS12620	COG0515	serine threonine protein kinase
AP9108_RS12620	COG1357	PFAM Pentapeptide repeats (8 copies)
AP9108_RS12630	COG0784	Response regulator, receiver
AP9108_RS12630	COG2205	protein histidine kinase activity
AP9108_RS12640	COG3842	ATPase activity
AP9108_RS12655	COG1653	transport
AP9108_RS12660	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AP9108_RS12665	COG2076	Multidrug Resistance protein
AP9108_RS12685	COG1357	PFAM Pentapeptide repeats (8 copies)
AP9108_RS12685	COG0515	serine threonine protein kinase
AP9108_RS12690	COG1357	PFAM Pentapeptide repeats (8 copies)
AP9108_RS12690	COG0515	serine threonine protein kinase
AP9108_RS12710	COG1252	NADH dehydrogenase
AP9108_RS12715	COG0802	atpase or kinase
AP9108_RS12725	COG1136	(ABC) transporter
AP9108_RS12745	COG0713	ATP synthesis coupled electron transport
AP9108_RS12755	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AP9108_RS12760	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AP9108_RS12765	COG0372	Belongs to the citrate synthase family
AP9108_RS12770	COG2062	phosphohistidine phosphatase, SixA
AP9108_RS12780	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AP9108_RS12790	COG0612	Peptidase, M16
AP9108_RS12845	COG0135	phosphoribosylanthranilate isomerase activity
AP9108_RS12860	COG0358	DNA primase activity
AP9108_RS12880	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AP9108_RS12900	COG1215	transferase activity, transferring glycosyl groups
AP9108_RS12915	COG0347	Belongs to the P(II) protein family
AP9108_RS13035	COG2270	Major facilitator Superfamily
AP9108_RS13065	COG0745	RESPONSE REGULATOR receiver
AP9108_RS13085	COG0589	response to stress
AP9108_RS13095	COG0268	Binds directly to 16S ribosomal RNA
AP9108_RS13100	COG0084	hydrolase, TatD family'
AP9108_RS13115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AP9108_RS13230	COG2211	Major facilitator Superfamily
AP9108_RS13245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AP9108_RS13295	COG0457	Tetratricopeptide repeat
AP9108_RS13295	COG0463	Glycosyl transferase, family 2
AP9108_RS13305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AP9108_RS13310	COG0589	response to stress
AP9108_RS13315	COG0824	Thioesterase
AP9108_RS13325	COG3300	MHYT domain
AP9108_RS13325	COG5001	Diguanylate cyclase
AP9108_RS13335	COG5001	Diguanylate cyclase
AP9108_RS13335	COG2203	Gaf domain
AP9108_RS13335	COG4251	negative regulation of phosphorylation
AP9108_RS13335	COG3706	GGDEF domain
AP9108_RS13355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AP9108_RS13360	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AP9108_RS13360	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AP9108_RS13370	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AP9108_RS13380	COG4279	zinc finger
AP9108_RS13415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AP9108_RS13415	COG1116	anion transmembrane transporter activity
AP9108_RS13420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AP9108_RS13425	COG1116	anion transmembrane transporter activity
AP9108_RS13425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AP9108_RS13435	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
AP9108_RS13460	COG0799	negative regulation of ribosome biogenesis
AP9108_RS13465	COG0297	glycogen (starch) synthase activity
AP9108_RS13475	COG1090	epimerase
AP9108_RS13480	COG1160	GTP binding
AP9108_RS13500	COG2205	protein histidine kinase activity
AP9108_RS13500	COG4999	Histidine kinase
AP9108_RS13500	COG3437	response regulator, receiver
AP9108_RS13500	COG3850	Histidine kinase
AP9108_RS13570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AP9108_RS13580	COG0525	valine-tRNA ligase activity
AP9108_RS13585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AP9108_RS13670	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AP9108_RS13810	COG0656	L-ascorbic acid biosynthetic process
AP9108_RS13855	COG0450	alkyl hydroperoxide reductase
AP9108_RS13860	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AP9108_RS13870	COG0463	Glycosyl transferase, family 2
AP9108_RS13870	COG1216	Glycosyl transferase, family 2
AP9108_RS13880	COG1215	transferase activity, transferring glycosyl groups
AP9108_RS13885	COG0542	response to heat
AP9108_RS13890	COG0346	lactoylglutathione lyase activity
AP9108_RS13925	COG1473	amidohydrolase
AP9108_RS14200	COG0436	Aminotransferase
AP9108_RS14205	COG1619	proteins homologs of microcin C7 resistance protein MccF
AP9108_RS14210	COG0384	phenazine biosynthesis protein PhzF
AP9108_RS14215	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AP9108_RS14395	COG0829	nickel cation binding
AP9108_RS14400	COG0831	urea catabolic process
AP9108_RS14405	COG0832	Belongs to the urease beta subunit family
AP9108_RS14415	COG3706	GGDEF domain
AP9108_RS14435	COG1649	PFAM Uncharacterised BCR, COG1649
AP9108_RS14445	COG1301	dicarboxylic acid transport
AP9108_RS14450	COG1794	racemase activity, acting on amino acids and derivatives
AP9108_RS14500	COG0516	GMP reductase activity
AP9108_RS14505	COG3118	belongs to the thioredoxin family
AP9108_RS14515	COG0745	RESPONSE REGULATOR receiver
AP9108_RS14520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AP9108_RS14555	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AP9108_RS14570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AP9108_RS14575	COG0140	phosphoribosyl-ATP diphosphatase activity
AP9108_RS14575	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AP9108_RS14600	COG2308	Evidence 4 Homologs of previously reported genes of
AP9108_RS14610	COG0540	Belongs to the ATCase OTCase family
AP9108_RS14630	COG1132	(ABC) transporter
AP9108_RS14640	COG0443	Heat shock 70 kDa protein
AP9108_RS14660	COG0800	Aldolase
AP9108_RS14665	COG0435	Glutathione S-transferase
AP9108_RS14680	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AP9108_RS14685	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AP9108_RS14695	COG1691	(AIR) carboxylase
AP9108_RS14905	COG0527	aspartate kinase activity
AP9108_RS14910	COG0701	Predicted permease
AP9108_RS14930	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AP9108_RS14945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AP9108_RS14955	COG0745	RESPONSE REGULATOR receiver
AP9108_RS14960	COG2201	protein-glutamate methylesterase activity
AP9108_RS14965	COG0784	Response regulator, receiver
AP9108_RS14965	COG0643	Histidine kinase
AP9108_RS14965	COG2198	Histidine kinase
AP9108_RS14970	COG5278	phosphoserine phosphatase activity
AP9108_RS14970	COG0840	transmembrane signaling receptor activity
AP9108_RS14990	COG3854	ATPases associated with a variety of cellular activities
AP9108_RS15005	COG1615	UPF0182 protein
AP9108_RS15075	COG0434	BtpA family
AP9108_RS15080	COG4243	Vitamin k epoxide reductase
AP9108_RS15090	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AP9108_RS15105	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AP9108_RS15110	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AP9108_RS15115	COG0750	zinc metalloprotease
AP9108_RS15120	COG3769	mannosylglycerate metabolic process
AP9108_RS15135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AP9108_RS15155	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AP9108_RS15165	COG0443	Heat shock 70 kDa protein
AP9108_RS15170	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AP9108_RS15180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AP9108_RS15195	COG2337	Toxic component of a toxin-antitoxin (TA) module
AP9108_RS15230	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AP9108_RS15235	COG2894	cell division
AP9108_RS15240	COG0850	regulation of cytokinetic process
AP9108_RS15260	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AP9108_RS15270	COG0745	RESPONSE REGULATOR receiver
AP9108_RS15360	COG0640	Transcriptional regulator
AP9108_RS15380	COG1216	Glycosyl transferase, family 2
AP9108_RS15400	COG2274	protein secretion by the type I secretion system
AP9108_RS15455	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AP9108_RS15470	COG0438	transferase activity, transferring glycosyl groups
AP9108_RS15480	COG0436	Aminotransferase
AP9108_RS15490	COG0189	ligase activity
AP9108_RS15525	COG2205	protein histidine kinase activity
AP9108_RS15540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AP9108_RS15560	COG4243	Vitamin k epoxide reductase
AP9108_RS15565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AP9108_RS15570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AP9108_RS15635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AP9108_RS15640	COG1704	LemA family
AP9108_RS15650	COG0312	modulator of DNA gyrase
AP9108_RS15675	COG5002	protein histidine kinase activity
AP9108_RS15700	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AP9108_RS15805	COG2326	polyphosphate kinase activity
AP9108_RS15820	COG4172	Belongs to the ABC transporter superfamily
AP9108_RS15825	COG0284	orotidine-5'-phosphate decarboxylase activity
AP9108_RS15830	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AP9108_RS15840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AP9108_RS15870	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AP9108_RS15900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AP9108_RS15910	COG0589	response to stress
AP9108_RS15915	COG0126	phosphoglycerate kinase activity
AP9108_RS15920	COG2205	protein histidine kinase activity
AP9108_RS15920	COG0784	Response regulator, receiver
AP9108_RS15950	COG0463	Glycosyl transferase, family 2
AP9108_RS15955	COG2201	protein-glutamate methylesterase activity
AP9108_RS15965	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AP9108_RS16015	COG0175	sulfate reduction
AP9108_RS16025	COG1525	nuclease
AP9108_RS16045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AP9108_RS16060	COG2205	protein histidine kinase activity
AP9108_RS16060	COG0784	Response regulator, receiver
AP9108_RS16065	COG0488	(ABC) transporter
AP9108_RS16090	COG2226	methyltransferase
AP9108_RS16095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AP9108_RS16100	COG2203	Gaf domain
AP9108_RS16100	COG5001	Diguanylate cyclase
AP9108_RS16100	COG3706	GGDEF domain
AP9108_RS16100	COG4251	negative regulation of phosphorylation
AP9108_RS16165	COG0251	oxidation-reduction process
AP9108_RS16170	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AP9108_RS16180	COG0419	ATPase involved in DNA repair
AP9108_RS16185	COG1597	lipid kinase activity
AP9108_RS16200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AP9108_RS16205	COG0564	pseudouridine synthase activity
AP9108_RS16215	COG0577	efflux transmembrane transporter activity
AP9108_RS16215	COG1136	(ABC) transporter
AP9108_RS16250	COG2205	protein histidine kinase activity
AP9108_RS16265	COG0788	formyltetrahydrofolate deformylase activity
AP9108_RS16545	COG0515	serine threonine protein kinase
AP9108_RS16545	COG1357	PFAM Pentapeptide repeats (8 copies)
AP9108_RS16555	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AP9108_RS16560	COG1376	ErfK ybiS ycfS ynhG family protein
AP9108_RS16570	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AP9108_RS16580	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AP9108_RS16585	COG0668	transmembrane transport
AP9108_RS16625	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AP9108_RS16625	COG3264	Mechanosensitive ion channel
AP9108_RS16635	COG0217	transcriptional regulatory protein
AP9108_RS16660	COG2815	serine threonine protein kinase
AP9108_RS16660	COG0515	serine threonine protein kinase
AP9108_RS16665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AP9108_RS16670	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AP9108_RS16680	COG0330	HflC and HflK could
AP9108_RS16705	COG3842	ATPase activity
AP9108_RS16865	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AP9108_RS16965	COG3239	Fatty acid desaturase
AP9108_RS16975	COG3842	ATPase activity
AP9108_RS16980	COG4597	amino acid ABC transporter
AP9108_RS16985	COG0765	amino acid transport
AP9108_RS17015	COG0167	dihydroorotate dehydrogenase activity
AP9108_RS17035	COG1518	maintenance of DNA repeat elements
AP9108_RS17085	COG0515	serine threonine protein kinase
AP9108_RS17085	COG2815	serine threonine protein kinase
AP9108_RS17180	COG1332	CRISPR-associated RAMP protein, Csm5 family
AP9108_RS17190	COG1337	RAMP superfamily
AP9108_RS17235	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AP9108_RS17240	COG0534	Mate efflux family protein
AP9108_RS17245	COG0556	nucleotide-excision repair
AP9108_RS17250	COG0123	including yeast histone deacetylase and acetoin utilization protein
AP9108_RS17255	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AP9108_RS17270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AP9108_RS17275	COG0163	prenyltransferase activity
AP9108_RS17285	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AP9108_RS17290	COG0514	ATP-dependent DNA helicase (RecQ)
AP9108_RS17300	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AP9108_RS17325	COG0193	aminoacyl-tRNA hydrolase activity
AP9108_RS17330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AP9108_RS17345	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AP9108_RS17350	COG1234	tRNA 3'-trailer cleavage
AP9108_RS17370	COG0745	RESPONSE REGULATOR receiver
AP9108_RS17380	COG3659	wide pore channel activity
AP9108_RS17385	COG3266	domain, Protein
AP9108_RS17385	COG0515	serine threonine protein kinase
AP9108_RS17415	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AP9108_RS17415	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AP9108_RS17430	COG1132	(ABC) transporter
AP9108_RS17440	COG1028	Short-chain dehydrogenase reductase Sdr
AP9108_RS17505	COG0484	heat shock protein binding
AP9108_RS17510	COG0740	serine-type endopeptidase activity
AP9108_RS17515	COG0740	serine-type endopeptidase activity
AP9108_RS17520	COG0740	serine-type endopeptidase activity
AP9108_RS17525	COG2304	oxidoreductase activity
AP9108_RS17530	COG0194	GDP metabolic process
AP9108_RS17535	COG2052	Domain of unknown function (DUF370)
AP9108_RS17885	COG0515	serine threonine protein kinase
AP9108_RS17885	COG1357	PFAM Pentapeptide repeats (8 copies)
AP9108_RS17895	COG0724	RNA recognition motif
AP9108_RS17915	COG0438	transferase activity, transferring glycosyl groups
AP9108_RS17915	COG1216	Glycosyl transferase, family 2
AP9108_RS17970	COG0204	Acyl-transferase
AP9108_RS18005	COG0436	Aminotransferase
AP9108_RS18015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AP9108_RS18025	COG1530	ribonuclease E activity
AP9108_RS18030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AP9108_RS18045	COG1605	Chorismate mutase
AP9108_RS18045	COG0077	Prephenate dehydratase
AP9108_RS18050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AP9108_RS18080	COG0316	Belongs to the HesB IscA family
AP9108_RS18100	COG2205	protein histidine kinase activity
AP9108_RS18100	COG0784	Response regulator, receiver
AP9108_RS18110	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AP9108_RS18140	COG1587	Uroporphyrinogen-III synthase
AP9108_RS18155	COG2010	Cytochrome c
AP9108_RS18165	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AP9108_RS18185	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AP9108_RS18205	COG1216	Glycosyl transferase, family 2
AP9108_RS18220	COG3437	response regulator, receiver
AP9108_RS18220	COG4999	Histidine kinase
AP9108_RS18220	COG2205	protein histidine kinase activity
AP9108_RS18220	COG3850	Histidine kinase
AP9108_RS18230	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AP9108_RS18295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AP9108_RS18310	COG2010	Cytochrome c
AP9108_RS18370	COG4451	ribulose bisphosphate carboxylase, small
AP9108_RS18370	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AP9108_RS18415	COG0181	hydroxymethylbilane synthase activity
AP9108_RS18765	COG1132	(ABC) transporter
AP9108_RS18770	COG1672	PFAM Archaeal ATPase
AP9108_RS18770	COG2319	Wd-40 repeat
AP9108_RS18790	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AP9108_RS18795	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AP9108_RS18795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AP9108_RS18825	COG0830	nickel cation binding
AP9108_RS18830	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AP9108_RS18835	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AP9108_RS18840	COG2226	methyltransferase
AP9108_RS18855	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AP9108_RS18870	COG0363	glucosamine-6-phosphate deaminase activity
AP9108_RS18875	COG1716	ATPase activity
AP9108_RS18905	COG2886	Uncharacterised protein family (UPF0175)
AP9108_RS19150	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AP9108_RS19160	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AP9108_RS19165	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AP9108_RS19170	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AP9108_RS19240	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AP9108_RS19455	COG0454	-acetyltransferase
AP9108_RS19485	COG1247	-acetyltransferase
AP9108_RS19490	COG0297	glycogen (starch) synthase activity
AP9108_RS19500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AP9108_RS19510	COG0028	Belongs to the TPP enzyme family
AP9108_RS19520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AP9108_RS19530	COG2267	carboxylic ester hydrolase activity
AP9108_RS19535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AP9108_RS19540	COG1331	Highly conserved protein containing a thioredoxin domain
AP9108_RS19560	COG4251	negative regulation of phosphorylation
AP9108_RS19565	COG4783	chaperone-mediated protein folding
AP9108_RS19570	COG2199	diguanylate cyclase activity
AP9108_RS19570	COG2200	EAL domain
AP9108_RS19625	COG1598	PFAM Uncharacterised protein family UPF0150
AP9108_RS19690	COG1252	NADH dehydrogenase
AP9108_RS19705	COG2264	protein methyltransferase activity
AP9108_RS19710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AP9108_RS19745	COG0515	serine threonine protein kinase
AP9108_RS19745	COG1357	PFAM Pentapeptide repeats (8 copies)
AP9108_RS19800	COG2091	lysine biosynthetic process via aminoadipic acid
AP9108_RS19815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AP9108_RS19820	COG0006	proline dipeptidase activity
AP9108_RS19835	COG4451	ribulose bisphosphate carboxylase, small
AP9108_RS19845	COG1850	ribulose-bisphosphate carboxylase activity
AP9108_RS19850	COG0583	DNA-binding transcription factor activity
AP9108_RS19875	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AP9108_RS19895	COG0484	heat shock protein binding
AP9108_RS19940	COG4636	protein conserved in cyanobacteria
AP9108_RS19950	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AP9108_RS19965	COG5635	Nacht domain
AP9108_RS19965	COG2319	Wd-40 repeat
AP9108_RS19970	COG1748	Saccharopine dehydrogenase
AP9108_RS19980	COG0629	single-stranded DNA binding
AP9108_RS19995	COG2226	methyltransferase
AP9108_RS20000	COG4399	Belongs to the UPF0754 family
AP9108_RS20005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AP9108_RS20010	COG1160	GTP binding
AP9108_RS20015	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AP9108_RS20030	COG1799	cell septum assembly
AP9108_RS20035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AP9108_RS20040	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AP9108_RS20125	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AP9108_RS20140	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AP9108_RS20140	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AP9108_RS20160	COG4245	von Willebrand factor, type A
AP9108_RS20175	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AP9108_RS20175	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AP9108_RS20185	COG0515	serine threonine protein kinase
AP9108_RS20215	COG1450	Type ii and iii secretion system protein
AP9108_RS20220	COG0776	regulation of translation
AP9108_RS20225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AP9108_RS20235	COG0322	excinuclease ABC activity
AP9108_RS20240	COG2124	cytochrome p450
AP9108_RS20255	COG1819	glycosyl
AP9108_RS20270	COG0142	geranyltranstransferase activity
AP9108_RS20290	COG0579	oxidoreductase
AP9108_RS20315	COG0501	Belongs to the peptidase M48B family
AP9108_RS20320	COG1704	LemA family
AP9108_RS20325	COG3977	Valine--pyruvate aminotransferase
AP9108_RS20345	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AP9108_RS20380	COG2239	Acts as a magnesium transporter
AP9108_RS20385	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AP9108_RS20420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AP9108_RS20425	COG0515	serine threonine protein kinase
AP9108_RS20425	COG3266	domain, Protein
AP9108_RS20430	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AP9108_RS20440	COG1834	amidinotransferase
AP9108_RS20475	COG1166	arginine decarboxylase activity
AP9108_RS20480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AP9108_RS20485	COG1640	4-alpha-glucanotransferase
AP9108_RS20495	COG1640	4-alpha-glucanotransferase
AP9108_RS20545	COG0745	RESPONSE REGULATOR receiver
AP9108_RS20550	COG2197	response regulator
AP9108_RS20560	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AP9108_RS20580	COG1487	ribonuclease activity
AP9108_RS20595	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AP9108_RS20595	COG0519	Catalyzes the synthesis of GMP from XMP
AP9108_RS20620	COG1104	cysteine desulfurase activity
AP9108_RS20695	COG1104	cysteine desulfurase activity
AP9108_RS20705	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AP9108_RS20710	COG0805	protein transport
AP9108_RS20730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AP9108_RS20740	COG1216	Glycosyl transferase, family 2
AP9108_RS20750	COG0827	DNA restriction-modification system
AP9108_RS20755	COG0270	DNA (cytosine-5-)-methyltransferase activity
AP9108_RS20760	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AP9108_RS20765	COG4251	negative regulation of phosphorylation
AP9108_RS20765	COG3706	GGDEF domain
AP9108_RS20765	COG2203	Gaf domain
AP9108_RS20765	COG5001	Diguanylate cyclase
AP9108_RS20770	COG1187	pseudouridine synthase activity
AP9108_RS20780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AP9108_RS20790	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AP9108_RS20805	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
AP9108_RS20810	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AP9108_RS20815	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AP9108_RS20820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AP9108_RS20825	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AP9108_RS20835	COG1132	(ABC) transporter
AP9108_RS20855	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AP9108_RS20880	COG3842	ATPase activity
AP9108_RS20890	COG1176	ABC-type spermidine putrescine transport system, permease component I
AP9108_RS20895	COG1177	transmembrane transport
AP9108_RS20900	COG0196	riboflavin kinase activity
AP9108_RS20915	COG0714	Associated with various cellular activities
AP9108_RS20930	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AP9108_RS20935	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AP9108_RS20940	COG1304	FMN binding
AP9108_RS20955	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AP9108_RS20960	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AP9108_RS20965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AP9108_RS20965	COG1754	DNA topoisomerase type I activity
AP9108_RS20975	COG0612	Peptidase, M16
AP9108_RS20980	COG0390	transport system, permease component
AP9108_RS21005	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AP9108_RS21010	COG1372	Participates in initiation and elongation during chromosome replication
AP9108_RS21010	COG0187	DNA topoisomerase II activity
AP9108_RS21020	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AP9108_RS21025	COG0740	serine-type endopeptidase activity
AP9108_RS21030	COG0544	peptidyl-prolyl cis-trans isomerase activity
AP9108_RS21035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AP9108_RS21040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AP9108_RS21045	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AP9108_RS21050	COG3829	transcription factor binding
AP9108_RS21050	COG3290	protein histidine kinase activity
AP9108_RS21060	COG4948	Mandelate Racemase Muconate Lactonizing
AP9108_RS21070	COG1192	Involved in chromosome partitioning
AP9108_RS21075	COG0596	Alpha beta hydrolase
AP9108_RS21090	COG3300	MHYT domain
AP9108_RS21090	COG5001	Diguanylate cyclase
AP9108_RS21095	COG2239	Acts as a magnesium transporter
AP9108_RS21155	COG1185	polyribonucleotide nucleotidyltransferase activity
AP9108_RS21160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AP9108_RS21170	COG1028	Short-chain dehydrogenase reductase Sdr
AP9108_RS21200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AP9108_RS21210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AP9108_RS21210	COG2022	thiamine diphosphate biosynthetic process
AP9108_RS21375	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AP9108_RS21390	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AP9108_RS21395	COG1122	ATPase activity
AP9108_RS21400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AP9108_RS21410	COG0515	serine threonine protein kinase
AP9108_RS21410	COG1357	PFAM Pentapeptide repeats (8 copies)
AP9108_RS21415	COG1064	alcohol dehydrogenase
AP9108_RS21420	COG1012	belongs to the aldehyde dehydrogenase family
AP9108_RS21420	COG1454	alcohol dehydrogenase
AP9108_RS21425	COG3903	Transcriptional regulator
AP9108_RS21425	COG2319	Wd-40 repeat
AP9108_RS21440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AP9108_RS21465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AP9108_RS21480	COG1950	PFAM Membrane protein of
AP9108_RS21500	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AP9108_RS21510	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AP9108_RS21515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AP9108_RS21520	COG3906	Belongs to the UPF0473 family
AP9108_RS21525	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AP9108_RS21570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AP9108_RS21580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AP9108_RS21600	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AP9108_RS21605	COG4251	negative regulation of phosphorylation
AP9108_RS21630	COG3706	GGDEF domain
AP9108_RS21630	COG5001	Diguanylate cyclase
AP9108_RS21630	COG2203	Gaf domain
AP9108_RS21630	COG4251	negative regulation of phosphorylation
AP9108_RS21635	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AP9108_RS21660	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AP9108_RS21665	COG1902	pentaerythritol trinitrate reductase activity
AP9108_RS21685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AP9108_RS21690	COG0431	NADPH-dependent FMN reductase
AP9108_RS21695	COG0798	PFAM Bile acid sodium symporter
AP9108_RS21850	COG1940	carbohydrate kinase activity
AP9108_RS21855	COG2211	Major facilitator Superfamily
AP9108_RS21905	COG0723	plastoquinol--plastocyanin reductase activity
AP9108_RS21910	COG3258	Cytochrome c
AP9108_RS21985	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AP9108_RS21995	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AP9108_RS22035	COG0003	Pfam Anion-transporting ATPase
AP9108_RS22130	COG1185	polyribonucleotide nucleotidyltransferase activity
AP9108_RS22155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AP9108_RS22160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AP9108_RS22185	COG0741	lytic transglycosylase activity
AP9108_RS22200	COG0191	fructose-bisphosphate aldolase activity
AP9108_RS22210	COG0676	glucose-6-phosphate 1-epimerase activity
AP9108_RS22215	COG2843	Capsule synthesis protein
AP9108_RS22225	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AP9108_RS22230	COG3751	2OG-Fe(II) oxygenase superfamily
AP9108_RS22235	COG3751	2OG-Fe(II) oxygenase superfamily
AP9108_RS22285	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AP9108_RS22290	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AP9108_RS22310	COG2211	Major facilitator Superfamily
AP9108_RS22340	COG0640	Transcriptional regulator
AP9108_RS22385	COG1357	PFAM Pentapeptide repeats (8 copies)
AP9108_RS22385	COG0515	serine threonine protein kinase
AP9108_RS22390	COG0515	serine threonine protein kinase
AP9108_RS22390	COG1357	PFAM Pentapeptide repeats (8 copies)
AP9108_RS22395	COG0515	serine threonine protein kinase
AP9108_RS22395	COG1357	PFAM Pentapeptide repeats (8 copies)
AP9108_RS22400	COG0515	serine threonine protein kinase
AP9108_RS22400	COG1357	PFAM Pentapeptide repeats (8 copies)
AP9108_RS22415	COG0415	Belongs to the DNA photolyase family
AP9108_RS22425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AP9108_RS22435	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AP9108_RS22455	COG1192	Involved in chromosome partitioning
AP9108_RS22465	COG2373	Large extracellular alpha-helical protein
AP9108_RS22470	COG0837	glucose binding
AP9108_RS22475	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AP9108_RS22480	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AP9108_RS22485	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AP9108_RS22490	COG0484	heat shock protein binding
AP9108_RS22515	COG1606	tRNA processing
AP9108_RS22545	COG0170	dolichyl monophosphate biosynthetic process
AP9108_RS22635	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AP9108_RS22640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AP9108_RS22645	COG0668	transmembrane transport
AP9108_RS22795	COG1131	(ABC) transporter
AP9108_RS22820	COG2202	Pas domain
AP9108_RS22820	COG2205	protein histidine kinase activity
AP9108_RS22825	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AP9108_RS22830	COG1234	tRNA 3'-trailer cleavage
AP9108_RS22875	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
AP9108_RS22885	COG4245	von Willebrand factor, type A
AP9108_RS22920	COG3259	Nickel-dependent hydrogenase
AP9108_RS22925	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
AP9108_RS22935	COG1151	hydroxylamine reductase activity
AP9108_RS22945	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AP9108_RS22950	COG0298	carbon dioxide binding
AP9108_RS22955	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AP9108_RS22955	COG0674	pyruvate-flavodoxin oxidoreductase activity
AP9108_RS22955	COG1013	pyruvate-flavodoxin oxidoreductase activity
AP9108_RS22955	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AP9108_RS22960	COG0167	dihydroorotate dehydrogenase activity
AP9108_RS22970	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AP9108_RS22980	COG0390	transport system, permease component
AP9108_RS23000	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AP9108_RS23005	COG2205	protein histidine kinase activity
AP9108_RS23080	COG0542	response to heat
AP9108_RS23110	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AP9108_RS23115	COG0457	Tetratricopeptide repeat
AP9108_RS23150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AP9108_RS23150	COG2205	protein histidine kinase activity
AP9108_RS23170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AP9108_RS23175	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AP9108_RS23180	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AP9108_RS23185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AP9108_RS23190	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AP9108_RS23220	COG2340	Cysteine-rich secretory protein family
AP9108_RS23380	COG0297	glycogen (starch) synthase activity
AP9108_RS23480	COG1162	GTPase activity
AP9108_RS23495	COG0445	tRNA wobble uridine modification
AP9108_RS23510	COG1215	transferase activity, transferring glycosyl groups
AP9108_RS23650	COG1028	Short-chain dehydrogenase reductase Sdr
AP9108_RS23660	COG1305	Transglutaminase-like
AP9108_RS23675	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AP9108_RS23685	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AP9108_RS23700	COG2205	protein histidine kinase activity
AP9108_RS23700	COG0784	Response regulator, receiver
AP9108_RS23705	COG0180	Tryptophanyl-tRNA synthetase
AP9108_RS23740	COG3437	response regulator, receiver
AP9108_RS23740	COG3850	Histidine kinase
AP9108_RS23740	COG2205	protein histidine kinase activity
AP9108_RS23740	COG4999	Histidine kinase
AP9108_RS23745	COG0492	ferredoxin-NADP+ reductase activity
AP9108_RS23755	COG1028	Short-chain dehydrogenase reductase Sdr
AP9108_RS23760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AP9108_RS23770	COG4636	protein conserved in cyanobacteria
AP9108_RS23775	COG4636	protein conserved in cyanobacteria
AP9108_RS23815	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AP9108_RS23830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AP9108_RS23835	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AP9108_RS23850	COG0024	Methionine aminopeptidase
AP9108_RS23855	COG0745	RESPONSE REGULATOR receiver
AP9108_RS23875	COG3757	hydrolase, family 25
AP9108_RS23880	COG2226	methyltransferase
AP9108_RS23885	COG0492	ferredoxin-NADP+ reductase activity
AP9108_RS23895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AP9108_RS23900	COG1012	belongs to the aldehyde dehydrogenase family
AP9108_RS23915	COG0179	Fumarylacetoacetate (FAA) hydrolase
AP9108_RS23920	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AP9108_RS23945	COG1285	pathogenesis
AP9108_RS23950	COG0366	Alpha amylase catalytic
AP9108_RS23955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AP9108_RS23965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AP9108_RS23985	COG0745	RESPONSE REGULATOR receiver
AP9108_RS24010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AP9108_RS24015	COG1546	Belongs to the CinA family
AP9108_RS24015	COG1058	Belongs to the CinA family
AP9108_RS24025	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AP9108_RS24060	COG1480	7TM receptor with intracellular HD hydrolase
AP9108_RS24070	COG0495	leucyl-tRNA aminoacylation
AP9108_RS24095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AP9108_RS24110	COG0564	pseudouridine synthase activity
AP9108_RS24140	COG0116	Belongs to the methyltransferase superfamily
AP9108_RS24155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AP9108_RS24190	COG0123	including yeast histone deacetylase and acetoin utilization protein
AP9108_RS24205	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AP9108_RS24210	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AP9108_RS24390	COG0450	alkyl hydroperoxide reductase
AP9108_RS24415	COG2267	carboxylic ester hydrolase activity
AP9108_RS24420	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AP9108_RS24435	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AP9108_RS24440	COG3842	ATPase activity
AP9108_RS24455	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AP9108_RS24460	COG3437	response regulator, receiver
AP9108_RS24460	COG4999	Histidine kinase
AP9108_RS24460	COG3850	Histidine kinase
AP9108_RS24460	COG2205	protein histidine kinase activity
AP9108_RS24470	COG2205	protein histidine kinase activity
AP9108_RS24485	COG0504	CTP synthase activity
AP9108_RS24490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AP9108_RS24515	COG1715	Restriction endonuclease
AP9108_RS24550	COG0024	Methionine aminopeptidase
AP9108_RS24775	COG3920	Histidine kinase
AP9108_RS24775	COG2202	Pas domain
AP9108_RS24860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AP9108_RS24870	COG0039	L-malate dehydrogenase activity
AP9108_RS24885	COG1357	PFAM Pentapeptide repeats (8 copies)
AP9108_RS24885	COG0515	serine threonine protein kinase
AP9108_RS24965	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AP9108_RS24975	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AP9108_RS25010	COG1487	ribonuclease activity
AP9108_RS25020	COG3264	Mechanosensitive ion channel
AP9108_RS25020	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AP9108_RS25025	COG4208	sulfate ABC transporter
AP9108_RS25030	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AP9108_RS25045	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AP9108_RS25055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AP9108_RS25060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AP9108_RS25065	COG1045	serine acetyltransferase
AP9108_RS25070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AP9108_RS25075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AP9108_RS25080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AP9108_RS25085	COG1042	CoA-binding domain protein
AP9108_RS25085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AP9108_RS25085	COG0045	succinate-CoA ligase (ADP-forming) activity
AP9108_RS25090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AP9108_RS25100	COG1361	Conserved repeat domain
AP9108_RS25100	COG3266	domain, Protein
AP9108_RS25100	COG2911	Protein conserved in bacteria
AP9108_RS25105	COG2226	methyltransferase
AP9108_RS25115	COG0058	SHG alpha-glucan phosphorylase activity
AP9108_RS25125	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AP9108_RS25145	COG3621	Patatin-like phospholipase
AP9108_RS25235	COG0515	serine threonine protein kinase
AP9108_RS25235	COG3266	domain, Protein
AP9108_RS25245	COG0515	serine threonine protein kinase
AP9108_RS25265	COG1122	ATPase activity
AP9108_RS25275	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
AP9108_RS25285	COG1216	Glycosyl transferase, family 2
AP9108_RS25290	COG0137	argininosuccinate synthase activity
AP9108_RS25300	COG5322	oxidoreductase activity
AP9108_RS25305	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AP9108_RS25310	COG0395	ABC-type sugar transport system, permease component
AP9108_RS25320	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AP9108_RS25320	COG0438	transferase activity, transferring glycosyl groups
AP9108_RS25330	COG1012	belongs to the aldehyde dehydrogenase family
AP9108_RS25330	COG1454	alcohol dehydrogenase
AP9108_RS25335	COG0651	ATP synthesis coupled electron transport
AP9108_RS25340	COG1006	Multisubunit Na H antiporter MnhC subunit
AP9108_RS25345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AP9108_RS25375	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AP9108_RS25400	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AP9108_RS25405	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AP9108_RS25410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AP9108_RS25420	COG2205	protein histidine kinase activity
AP9108_RS25420	COG5002	protein histidine kinase activity
AP9108_RS25420	COG0784	Response regulator, receiver
AP9108_RS25465	COG0189	ligase activity
AP9108_RS25465	COG4067	protein conserved in archaea
AP9108_RS25490	COG1176	ABC-type spermidine putrescine transport system, permease component I
AP9108_RS25500	COG1177	transmembrane transport
AP9108_RS25510	COG0469	pyruvate kinase activity
AP9108_RS25515	COG0305	Participates in initiation and elongation during chromosome replication
AP9108_RS25515	COG1372	Participates in initiation and elongation during chromosome replication
AP9108_RS25520	COG0359	binds to the 23S rRNA
AP9108_RS25525	COG1126	abc transporter atp-binding protein
AP9108_RS25540	COG1131	(ABC) transporter
AP9108_RS25545	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AP9108_RS25560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AP9108_RS25565	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AP9108_RS25585	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AP9108_RS25595	COG2252	PERMEase
AP9108_RS25605	COG0628	permease
AP9108_RS25610	COG0697	spore germination
AP9108_RS25615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AP9108_RS25620	COG0302	gtp cyclohydrolase
AP9108_RS25625	COG1028	Short-chain dehydrogenase reductase Sdr
AP9108_RS25630	COG0825	malonyl-CoA metabolic process
AP9108_RS25640	COG0678	peroxiredoxin activity
AP9108_RS25645	COG0515	serine threonine protein kinase
AP9108_RS25645	COG1357	PFAM Pentapeptide repeats (8 copies)
AP9108_RS25670	COG3937	granule-associated protein
AP9108_RS25675	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AP9108_RS25680	COG0631	protein serine/threonine phosphatase activity
AP9108_RS25685	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AP9108_RS25695	COG0513	Belongs to the DEAD box helicase family
AP9108_RS25715	COG1070	Carbohydrate kinase
AP9108_RS25720	COG3773	Cell wall hydrolase
AP9108_RS25720	COG3409	Peptidoglycan-binding domain 1 protein
AP9108_RS25725	COG0151	Belongs to the GarS family
AP9108_RS25730	COG5002	protein histidine kinase activity
AP9108_RS25770	COG0429	hydrolase of the alpha beta-hydrolase fold
AP9108_RS25775	COG1357	PFAM Pentapeptide repeats (8 copies)
AP9108_RS25775	COG0515	serine threonine protein kinase
AP9108_RS25805	COG0702	epimerase
AP9108_RS25865	COG1132	(ABC) transporter
AP9108_RS25890	COG3118	belongs to the thioredoxin family
AP9108_RS25895	COG1028	Short-chain dehydrogenase reductase Sdr
AP9108_RS25900	COG0459	protein refolding
AP9108_RS25905	COG0745	RESPONSE REGULATOR receiver
AP9108_RS25910	COG5002	protein histidine kinase activity
AP9108_RS25930	COG0571	ribonuclease III activity
AP9108_RS25935	COG4245	von Willebrand factor, type A
AP9108_RS25955	COG5001	Diguanylate cyclase
AP9108_RS25955	COG2203	Gaf domain
AP9108_RS25955	COG4251	negative regulation of phosphorylation
AP9108_RS25955	COG3706	GGDEF domain
AP9108_RS25985	COG0142	geranyltranstransferase activity
AP9108_RS25990	COG0602	queuosine metabolic process
AP9108_RS25995	COG0023	Translation Initiation Factor
AP9108_RS26030	COG1496	oxidoreductase activity
AP9108_RS26035	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AP9108_RS26035	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AP9108_RS26040	COG0739	heme binding
AP9108_RS26050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AP9108_RS26100	COG2954	triphosphatase activity
AP9108_RS26120	COG2197	response regulator
AP9108_RS26130	COG0124	histidyl-tRNA synthetase
AP9108_RS26140	COG2319	Wd-40 repeat
AP9108_RS26140	COG4249	Peptidase C14 caspase catalytic subunit p20
AP9108_RS26140	COG2319	Wd-40 repeat
AP9108_RS26140	COG4249	Peptidase C14 caspase catalytic subunit p20
AP9108_RS26155	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AP9108_RS26165	COG2319	Wd-40 repeat
AP9108_RS26165	COG4249	Peptidase C14 caspase catalytic subunit p20
AP9108_RS26175	COG2205	protein histidine kinase activity
AP9108_RS26200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AP9108_RS26200	COG0072	phenylalanine-tRNA ligase activity
AP9108_RS26235	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AP9108_RS26305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AP9108_RS26330	COG0416	fatty acid biosynthetic process
AP9108_RS26340	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AP9108_RS26345	COG5002	protein histidine kinase activity
AP9108_RS26455	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AP9108_RS26525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AP9108_RS26590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AP9108_RS26925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AP9108_RS26935	COG0542	response to heat
AP9108_RS26950	COG0542	response to heat
AP9108_RS27060	COG1404	Belongs to the peptidase S8 family
AP9108_RS27110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AP9108_RS27110	COG0426	domain, Protein
AP9108_RS27130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AP9108_RS27155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AP9108_RS27165	COG3956	TIGRFAM MazG family protein
AP9108_RS27210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AP9108_RS27230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AP9108_RS27245	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AP9108_RS27250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AP9108_RS27255	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AP9108_RS27260	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AP9108_RS27265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AP9108_RS27285	COG0530	calcium, potassium:sodium antiporter activity
AP9108_RS27290	COG0018	arginyl-trna synthetase
AP9108_RS27310	COG5002	protein histidine kinase activity
AP9108_RS27310	COG0784	Response regulator, receiver
AP9108_RS27320	COG1490	D-aminoacyl-tRNA deacylase activity
AP9108_RS27325	COG0523	cobalamin synthesis protein
AP9108_RS27330	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AP9108_RS27360	COG0438	transferase activity, transferring glycosyl groups
AP9108_RS27375	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AP9108_RS27435	COG0583	DNA-binding transcription factor activity
AP9108_RS27720	COG1357	PFAM Pentapeptide repeats (8 copies)
AP9108_RS27720	COG0515	serine threonine protein kinase
AP9108_RS27765	COG1115	amino acid carrier protein
AP9108_RS27780	COG2319	Wd-40 repeat
AP9108_RS27780	COG4249	Peptidase C14 caspase catalytic subunit p20
AP9108_RS27800	COG0464	growth
AP9108_RS27820	COG0515	serine threonine protein kinase
AP9108_RS27830	COG0515	serine threonine protein kinase
AP9108_RS27885	COG0515	serine threonine protein kinase
AP9108_RS27890	COG0515	serine threonine protein kinase
AP9108_RS27910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AP9108_RS27925	COG0515	serine threonine protein kinase
AP9108_RS27930	COG1845	cytochrome c oxidase, subunit III
AP9108_RS27935	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AP9108_RS27950	COG0109	protoheme IX farnesyltransferase activity
AP9108_RS27960	COG5001	Diguanylate cyclase
AP9108_RS27960	COG4251	negative regulation of phosphorylation
AP9108_RS27960	COG3706	GGDEF domain
AP9108_RS27960	COG2203	Gaf domain
AP9108_RS27965	COG4251	negative regulation of phosphorylation
AP9108_RS27970	COG2205	protein histidine kinase activity
AP9108_RS27970	COG0784	Response regulator, receiver
AP9108_RS27970	COG2198	Histidine kinase
AP9108_RS27975	COG4251	negative regulation of phosphorylation
AP9108_RS27975	COG3706	GGDEF domain
AP9108_RS27975	COG2203	Gaf domain
AP9108_RS27975	COG5001	Diguanylate cyclase
AP9108_RS27980	COG1672	PFAM Archaeal ATPase
AP9108_RS27980	COG2319	Wd-40 repeat
AP9108_RS27990	COG3659	wide pore channel activity
AP9108_RS28045	COG0439	Biotin carboxylase
AP9108_RS28190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AP9108_RS28205	COG3266	domain, Protein
AP9108_RS28205	COG1361	Conserved repeat domain
AP9108_RS28205	COG2911	Protein conserved in bacteria
AP9108_RS28290	COG4585	Histidine kinase
AP9108_RS28295	COG2197	response regulator
AP9108_RS28335	COG1074	ATP-dependent DNA helicase activity
AP9108_RS28345	COG0515	serine threonine protein kinase
AP9108_RS28345	COG3266	domain, Protein
AP9108_RS28350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AP9108_RS28365	COG2217	Heavy metal translocating P-type atpase
AP9108_RS28370	COG0505	Belongs to the CarA family
AP9108_RS28380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AP9108_RS28425	COG4956	integral membrane protein (PIN domain superfamily)
AP9108_RS28440	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AP9108_RS28445	COG0149	triose-phosphate isomerase activity
AP9108_RS28475	COG0352	thiamine-phosphate diphosphorylase activity
AP9108_RS28505	COG1088	dTDP-glucose 4,6-dehydratase activity
AP9108_RS28515	COG2843	Capsule synthesis protein
AP9108_RS28545	COG1116	anion transmembrane transporter activity
AP9108_RS28545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AP9108_RS28550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AP9108_RS28565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AP9108_RS28570	COG0511	ligase activity, forming carbon-carbon bonds
AP9108_RS28585	COG3608	succinylglutamate desuccinylase aspartoacylase
AP9108_RS28595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AP9108_RS28595	COG4191	Histidine kinase
AP9108_RS28610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AP9108_RS28625	COG0720	synthase
AP9108_RS28645	COG0842	Transport permease protein
AP9108_RS28645	COG1716	ATPase activity
AP9108_RS28645	COG1131	(ABC) transporter
AP9108_RS28670	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AP9108_RS28675	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AP9108_RS28690	COG0405	Gamma-glutamyltransferase
AP9108_RS28720	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AP9108_RS28725	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AP9108_RS28730	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AP9108_RS28740	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AP9108_RS28755	COG1649	PFAM Uncharacterised BCR, COG1649
AP9108_RS28785	COG0577	efflux transmembrane transporter activity
AP9108_RS28785	COG1136	(ABC) transporter
AP9108_RS28810	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AP9108_RS28815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AP9108_RS28820	COG0577	efflux transmembrane transporter activity
AP9108_RS28820	COG1136	(ABC) transporter
AP9108_RS28825	COG2385	sporulation resulting in formation of a cellular spore
AP9108_RS28830	COG2183	response to ionizing radiation
AP9108_RS28850	COG2267	carboxylic ester hydrolase activity
AP9108_RS28860	COG3540	Alkaline phosphatase
AP9108_RS28870	COG0596	Alpha beta hydrolase
AP9108_RS28875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AP9108_RS28890	COG0572	uridine kinase
AP9108_RS28915	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AP9108_RS28925	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AP9108_RS28930	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AP9108_RS28935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AP9108_RS28955	COG0702	epimerase
AP9108_RS28960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AP9108_RS28980	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
AP9108_RS28985	COG2226	methyltransferase
AP9108_RS29020	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AP9108_RS29025	COG0052	Belongs to the universal ribosomal protein uS2 family
AP9108_RS29050	COG1002	Type II restriction enzyme, methylase subunits
AP9108_RS29055	COG1002	Type II restriction enzyme, methylase subunits
AP9108_RS29175	COG1002	Type II restriction enzyme, methylase subunits
AP9108_RS29310	COG0285	dihydrofolate synthase activity
AP9108_RS29325	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AP9108_RS29335	COG0133	tryptophan synthase activity
AP9108_RS29380	COG0251	oxidation-reduction process
AP9108_RS29400	COG1842	Phage shock protein A
AP9108_RS29420	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AP9108_RS29425	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AP9108_RS29430	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AP9108_RS29435	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AP9108_RS29435	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AP9108_RS29445	COG0314	molybdopterin synthase activity
AP9108_RS29450	COG1595	DNA-templated transcription, initiation
AP9108_RS29475	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AP9108_RS29480	COG1983	PspC domain protein
AP9108_RS29485	COG2081	HI0933 family
AP9108_RS29560	COG0632	four-way junction helicase activity
AP9108_RS29590	COG0758	DNA mediated transformation
AP9108_RS29590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AP9108_RS29600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AP9108_RS29615	COG1968	undecaprenyl-diphosphatase activity
AP9108_RS29625	COG0860	N-Acetylmuramoyl-L-alanine amidase
AP9108_RS29630	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AP9108_RS29640	COG0596	Alpha beta hydrolase
AP9108_RS29645	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AP9108_RS29650	COG1357	PFAM Pentapeptide repeats (8 copies)
AP9108_RS29650	COG0515	serine threonine protein kinase
AP9108_RS29670	COG0475	glutathione-regulated potassium exporter activity
AP9108_RS29670	COG0589	response to stress
AP9108_RS29705	COG0751	glycine-tRNA ligase activity
AP9108_RS29740	COG1316	TRANSCRIPTIONal
AP9108_RS29750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AP9108_RS29780	COG1175	transmembrane transport
AP9108_RS29795	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AP9108_RS29805	COG0649	NAD binding
AP9108_RS29810	COG0275	rRNA processing
AP9108_RS29825	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AP9108_RS29840	COG2205	protein histidine kinase activity
AP9108_RS29960	COG3266	domain, Protein
AP9108_RS29960	COG0515	serine threonine protein kinase
AP9108_RS29970	COG0515	serine threonine protein kinase
AP9108_RS29985	COG1475	DNA binding
AP9108_RS30000	COG0515	serine threonine protein kinase
AP9108_RS30040	COG1858	cytochrome C peroxidase
AP9108_RS30060	COG0469	pyruvate kinase activity
AP9108_RS30125	COG3243	poly(R)-hydroxyalkanoic acid synthase
AP9108_RS30145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AP9108_RS30160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AP9108_RS30170	COG0559	Belongs to the binding-protein-dependent transport system permease family
AP9108_RS30180	COG0411	ABC transporter
AP9108_RS30190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AP9108_RS30190	COG2022	thiamine diphosphate biosynthetic process
AP9108_RS30200	COG0300	oxidoreductase activity
AP9108_RS30285	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AP9108_RS30295	COG2203	Gaf domain
AP9108_RS30295	COG3706	GGDEF domain
AP9108_RS30295	COG5001	Diguanylate cyclase
AP9108_RS30295	COG4251	negative regulation of phosphorylation
AP9108_RS30300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AP9108_RS30320	COG0083	homoserine kinase activity
AP9108_RS30345	COG0515	serine threonine protein kinase
AP9108_RS30345	COG1357	PFAM Pentapeptide repeats (8 copies)
AP9108_RS30370	COG0166	Belongs to the GPI family
AP9108_RS30375	COG0857	belongs to the CobB CobQ family
AP9108_RS30375	COG0280	phosphate acetyltransferase
AP9108_RS30380	COG2203	Gaf domain
AP9108_RS30380	COG2200	EAL domain
AP9108_RS30380	COG2199	diguanylate cyclase activity
AP9108_RS30385	COG1716	ATPase activity
AP9108_RS30385	COG5001	Diguanylate cyclase
AP9108_RS30395	COG1733	regulation of RNA biosynthetic process
AP9108_RS30400	COG0574	Belongs to the PEP-utilizing enzyme family
AP9108_RS30400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AP9108_RS30420	COG4178	(ABC) transporter
AP9108_RS30425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AP9108_RS30450	COG4191	Histidine kinase
AP9108_RS30450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AP9108_RS30455	COG1028	Short-chain dehydrogenase reductase Sdr
AP9108_RS30525	COG0237	dephospho-CoA kinase activity
AP9108_RS30530	COG5398	heme oxygenase
AP9108_RS30535	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AP9108_RS30545	COG3852	Histidine kinase
AP9108_RS30560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AP9108_RS30580	COG0508	dehydrogenase complex catalyzes the overall conversion of
AP9108_RS30580	COG0022	dehydrogenase e1 component
AP9108_RS30585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AP9108_RS30590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AP9108_RS30605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AP9108_RS30610	COG0409	Hydrogenase expression formation protein
AP9108_RS30645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AP9108_RS30650	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AP9108_RS30670	COG1573	uracil-dna glycosylase
AP9108_RS30690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AP9108_RS30700	COG0484	heat shock protein binding
AP9108_RS30710	COG0456	acetyltransferase
AP9108_RS30720	COG0746	molybdenum cofactor guanylyltransferase activity
AP9108_RS30775	COG0514	ATP-dependent DNA helicase (RecQ)
AP9108_RS30785	COG0584	glycerophosphoryl diester phosphodiesterase
AP9108_RS30820	COG2131	deaminase
AP9108_RS31025	COG2815	serine threonine protein kinase
AP9108_RS31025	COG0515	serine threonine protein kinase
AP9108_RS31075	COG0312	modulator of DNA gyrase
AP9108_RS31080	COG0312	modulator of DNA gyrase
AP9108_RS31085	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AP9108_RS31100	COG0432	Pfam Uncharacterised protein family UPF0047
AP9108_RS31115	COG0247	lactate metabolic process
AP9108_RS31120	COG0277	FAD linked oxidase domain protein
AP9108_RS31135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AP9108_RS31140	COG1943	Transposase
AP9108_RS31145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AP9108_RS31150	COG2048	Heterodisulfide reductase, subunit B
AP9108_RS31155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AP9108_RS31160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AP9108_RS31165	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AP9108_RS31170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AP9108_RS31195	COG0628	permease
AP9108_RS31205	COG0745	RESPONSE REGULATOR receiver
AP9108_RS31225	COG0827	DNA restriction-modification system
AP9108_RS31230	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AP9108_RS31235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AP9108_RS31255	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AP9108_RS31265	COG0482	sulfurtransferase activity
AP9108_RS31270	COG1192	Involved in chromosome partitioning
AP9108_RS31295	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AP9108_RS31300	COG0594	ribonuclease P activity
AP9108_RS31310	COG0706	membrane insertase activity
AP9108_RS31325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AP9108_RS31340	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AP9108_RS31390	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AP9108_RS31420	COG0667	Aldo Keto reductase
AP9108_RS31435	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AP9108_RS31445	COG0343	queuine tRNA-ribosyltransferase activity
AP9108_RS31460	COG1672	PFAM Archaeal ATPase
AP9108_RS31465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AP9108_RS31470	COG0571	ribonuclease III activity
AP9108_RS31535	COG0535	radical SAM domain protein
AP9108_RS31550	COG4636	protein conserved in cyanobacteria
AP9108_RS31560	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AP9108_RS31660	COG1649	PFAM Uncharacterised BCR, COG1649
AP9108_RS31665	COG1696	Membrane protein involved in D-alanine export
AP9108_RS31670	COG0481	GTPase activity
AP9108_RS31680	COG0681	Belongs to the peptidase S26 family
AP9108_RS31700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AP9108_RS31705	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AP9108_RS31710	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AP9108_RS31730	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AP9108_RS31730	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AP9108_RS31745	COG0745	RESPONSE REGULATOR receiver
AP9108_RS31750	COG1366	Belongs to the anti-sigma-factor antagonist family
AP9108_RS31760	COG0783	Belongs to the Dps family
AP9108_RS31765	COG0539	negative regulation of cytoplasmic translation
AP9108_RS31775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AP9108_RS31780	COG2022	thiamine diphosphate biosynthetic process
AP9108_RS31795	COG0745	RESPONSE REGULATOR receiver
AP9108_RS31815	COG1193	negative regulation of DNA recombination
AP9108_RS31845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AP9108_RS31845	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AP9108_RS31915	COG1222	aaa ATPase
AP9108_RS31925	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AP9108_RS32030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AP9108_RS32040	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AP9108_RS32050	COG0731	radical SAM domain protein
AP9108_RS32080	COG0003	Pfam Anion-transporting ATPase
AP9108_RS32120	COG1077	Cell shape determining protein MreB Mrl
AP9108_RS32170	COG0019	diaminopimelate decarboxylase activity
AP9108_RS32190	COG2084	Dehydrogenase
AP9108_RS32200	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AP9108_RS32205	COG0066	3-isopropylmalate dehydratase activity
AP9108_RS32210	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AP9108_RS32215	COG0367	asparagine synthase
AP9108_RS32240	COG0546	phosphoglycolate phosphatase activity
AP9108_RS32370	COG1598	PFAM Uncharacterised protein family UPF0150