locus-tag	class	description
AYWB_RS00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
AYWB_RS00025	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
AYWB_RS00030	ENOG4105BZR	domain protein
AYWB_RS00035	ENOG4105CDU	Replicative dna helicase
AYWB_RS00040	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
AYWB_RS00055	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
AYWB_RS00065	ENOG4108V7D	UPF0397 protein
AYWB_RS00070	ENOG4108JJB	ABC transporter
AYWB_RS00080	ENOG4105C0H	protease
AYWB_RS00085	ENOG4107Y70	Heat shock protein
AYWB_RS00090	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
AYWB_RS00095	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
AYWB_RS00120	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
AYWB_RS00125	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
AYWB_RS00130	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
AYWB_RS00190	ENOG4105C22	threonyL-tRNA synthetase
AYWB_RS00220	ENOG4105C6K	Malic enzyme
AYWB_RS00230	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
AYWB_RS00255	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
AYWB_RS00260	ENOG4107ZR2	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AYWB_RS00265	ENOG4105CFG	Acts as a chaperone (By similarity)
AYWB_RS00270	ENOG4108P61	DnaJ domain protein
AYWB_RS00275	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
AYWB_RS00290	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
AYWB_RS00305	ENOG4105VEQ	Cold shock protein
AYWB_RS00340	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
AYWB_RS00380	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
AYWB_RS00415	ENOG4105DP4	dak2 domain fusion protein ylov
AYWB_RS00425	ENOG4108HM4	ABC transporter
AYWB_RS00430	ENOG4105D38	putrescine abc transporter
AYWB_RS00435	ENOG4105F38	ABC transporter, permease
AYWB_RS00440	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
AYWB_RS00450	ENOG4105CN5	Metallo-Beta-Lactamase
AYWB_RS00485	ENOG4105CN5	Metallo-Beta-Lactamase
AYWB_RS00490	ENOG4107FSS	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
AYWB_RS00495	ENOG4105K59	histidine triad (HIT) protein
AYWB_RS00510	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
AYWB_RS00525	ENOG41080V7	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
AYWB_RS00545	ENOG4105C4R	Atp-dependent dna helicase
AYWB_RS00555	ENOG4105C6E	dna polymerase iii
AYWB_RS00570	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
AYWB_RS00575	ENOG4105DJ4	phosphatidylserine decarboxylase
AYWB_RS00580	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
AYWB_RS00590	ENOG4105E5Q	amino acid AbC transporter
AYWB_RS00615	ENOG4105CRK	lysyL-tRNA synthetase
AYWB_RS00620	ENOG4105C0B	DNA polymerase III (alpha subunit)
AYWB_RS00635	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
AYWB_RS00640	ENOG4108H05	Phenylalanyl-tRNA synthetase subunit beta
AYWB_RS00650	ENOG4107RUY	(E1 component), alpha subunit
AYWB_RS00655	ENOG4105CPP	Dehydrogenase, E1 component
AYWB_RS00660	ENOG4105C7S	Dehydrogenase
AYWB_RS00665	ENOG4107QN2	dihydrolipoyl dehydrogenase
AYWB_RS00670	ENOG4105F8V	Hydrolase, tatD family
AYWB_RS00680	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
AYWB_RS00685	ENOG4107SU0	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
AYWB_RS00820	ENOG4105DQ6	Transposase
AYWB_RS00835	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
AYWB_RS00850	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
AYWB_RS00880	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
AYWB_RS00985	ENOG4105K70	DNA-binding protein
AYWB_RS01025	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
AYWB_RS01040	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
AYWB_RS01085	ENOG4105K70	DNA-binding protein
AYWB_RS01120	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
AYWB_RS01125	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
AYWB_RS01130	ENOG4105C8B	TIGR00159 family
AYWB_RS01135	ENOG4105EPR	degv family
AYWB_RS01160	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
AYWB_RS01165	ENOG41072GX	Peptidase M22 Glycoprotease
AYWB_RS01175	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AYWB_RS01180	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AYWB_RS01285	ENOG4105E5Q	amino acid AbC transporter
AYWB_RS01290	ENOG4108HW3	(ABC) transporter
AYWB_RS01295	ENOG4105CDA	abc transporter atp-binding protein
AYWB_RS01385	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
AYWB_RS01400	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
AYWB_RS01410	ENOG4105DQ6	Transposase
AYWB_RS01415	ENOG4105D1H	recombination factor protein RarA
AYWB_RS01420	ENOG4105DQ6	Transposase
AYWB_RS01455	ENOG4105DQ6	Transposase
AYWB_RS01475	ENOG4108Z4K	mutator MutT protein
AYWB_RS01485	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
AYWB_RS01490	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
AYWB_RS01495	ENOG4105K5M	30s ribosomal protein S16
AYWB_RS01500	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
AYWB_RS01505	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
AYWB_RS01510	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
AYWB_RS01515	ENOG4105C9B	Cysteine desulfurase
AYWB_RS01520	ENOG4107YH3	SUF system FeS assembly protein, NifU family
AYWB_RS01525	ENOG4105C31	Tryptophanyl-tRNA synthetase
AYWB_RS01530	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
AYWB_RS01550	ENOG4105C75	arginyL-tRNA synthetase
AYWB_RS01555	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
AYWB_RS01560	ENOG4105C1J	atp-dependent rna helicase
AYWB_RS01570	ENOG4107Y8I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
AYWB_RS01575	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
AYWB_RS01580	ENOG4105CIE	May be required for sporulation (By similarity)
AYWB_RS01585	ENOG41068RJ	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
AYWB_RS01590	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
AYWB_RS01595	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
AYWB_RS01610	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
AYWB_RS01625	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
AYWB_RS01630	ENOG4108007	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
AYWB_RS01635	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
AYWB_RS01805	ENOG4107R5S	dna adenine
AYWB_RS01895	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
AYWB_RS01900	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
AYWB_RS01945	ENOG4108790	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
AYWB_RS01960	ENOG4105DF9	Lipoate-protein, ligase
AYWB_RS01975	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
AYWB_RS01980	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
AYWB_RS01990	ENOG4107ZJC	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
AYWB_RS01995	ENOG4108VQJ	O-methyltransferase
AYWB_RS02000	ENOG4107YHV	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
AYWB_RS02015	ENOG4106H78	methyltransferase
AYWB_RS02020	ENOG410853A	UPF0154 protein
AYWB_RS02040	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
AYWB_RS02045	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
AYWB_RS02050	ENOG4107QSE	Dipeptidase
AYWB_RS02065	ENOG4105CA9	Pyruvate kinase
AYWB_RS02075	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
AYWB_RS02080	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
AYWB_RS02085	ENOG4107QYV	phosphohexose isomerase
AYWB_RS02095	ENOG4105CTQ	phosphohexokinase
AYWB_RS02105	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
AYWB_RS02120	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
AYWB_RS02125	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
AYWB_RS02130	ENOG4105D48	metallophosphoesterase
AYWB_RS02135	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
AYWB_RS02145	ENOG4105CGY	Dna recombination protein
AYWB_RS02160	ENOG4105CWE	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
AYWB_RS02165	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
AYWB_RS02180	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
AYWB_RS02185	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
AYWB_RS02190	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
AYWB_RS02195	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
AYWB_RS02200	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AYWB_RS02205	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AYWB_RS02210	ENOG41082SK	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
AYWB_RS02215	ENOG4107URM	50S ribosomal protein l10
AYWB_RS02220	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
AYWB_RS02225	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
AYWB_RS02230	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
AYWB_RS02240	ENOG4105WDJ	50S ribosomal protein L33
AYWB_RS02245	ENOG4105C2N	RNA methyltransferase TrmH family group 3
AYWB_RS02250	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
AYWB_RS02255	ENOG4107QUF	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
AYWB_RS02295	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
AYWB_RS02305	ENOG4105VG0	50S ribosomal protein l34
AYWB_RS02310	ENOG4107R1M	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity)
AYWB_RS02330	ENOG41084ED	50S ribosomal protein L33
AYWB_RS02350	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
AYWB_RS02355	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
AYWB_RS02360	ENOG4105CAT	Cytidine monophosphate kinase
AYWB_RS02365	ENOG4105FE9	pseudouridine synthase
AYWB_RS02370	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
AYWB_RS02375	ENOG4105K63	Thioredoxin
AYWB_RS02385	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
AYWB_RS02395	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
AYWB_RS02400	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
AYWB_RS02405	ENOG4105FA2	dna polymerase iii
AYWB_RS02410	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
AYWB_RS02415	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
AYWB_RS02420	ENOG4108ZT0	50S ribosomal protein l17
AYWB_RS02425	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AYWB_RS02430	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
AYWB_RS02435	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AYWB_RS02450	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
AYWB_RS02455	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
AYWB_RS02460	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
AYWB_RS02465	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
AYWB_RS02470	ENOG41086IJ	50S ribosomal protein L30
AYWB_RS02475	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
AYWB_RS02480	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
AYWB_RS02485	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
AYWB_RS02490	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
AYWB_RS02495	ENOG41082AF	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
AYWB_RS02500	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AYWB_RS02505	ENOG41080DU	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
AYWB_RS02510	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
AYWB_RS02515	ENOG41084D8	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
AYWB_RS02520	ENOG41082SA	50s ribosomal protein l29
AYWB_RS02525	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
AYWB_RS02530	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
AYWB_RS02535	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
AYWB_RS02540	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
AYWB_RS02545	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AYWB_RS02550	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
AYWB_RS02555	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
AYWB_RS02560	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
AYWB_RS02565	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
AYWB_RS02570	ENOG41082GS	50S ribosomal protein L32
AYWB_RS02580	ENOG4108JQ7	(ABC) transporter
AYWB_RS02585	ENOG4105C3U	ABC transporter
AYWB_RS02590	ENOG4107QSI	ABC, transporter
AYWB_RS02600	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
AYWB_RS02605	ENOG4105CTD	carboxy-peptidase
AYWB_RS02620	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
AYWB_RS02625	ENOG4105C3G	gtp-binding protein
AYWB_RS02630	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
AYWB_RS02635	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
AYWB_RS02640	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
AYWB_RS02645	ENOG4108JJB	ABC transporter
AYWB_RS02650	ENOG4108JJB	ABC transporter
AYWB_RS02675	ENOG4105BZA	Phosphoglycerate kinase
AYWB_RS02690	ENOG4105CP7	Triose-phosphate isomerase
AYWB_RS02695	ENOG4105KNE	Phosphatidate cytidylyltransferase
AYWB_RS02700	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
AYWB_RS02705	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
AYWB_RS02710	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
AYWB_RS02715	ENOG4105CE9	30S ribosomal protein S2
AYWB_RS02720	ENOG4107Z0P	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
AYWB_RS02770	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
AYWB_RS02775	ENOG4108UT2	hemolysin iii
AYWB_RS02790	ENOG4105C25	Primosomal protein n'
AYWB_RS02795	ENOG4105C37	(CBS) domain
AYWB_RS02800	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
AYWB_RS02810	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
AYWB_RS02820	ENOG4105CHV	Transcription elongation factor NusA
AYWB_RS02830	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
AYWB_RS02835	ENOG4105F0N	pyrophosphate phospho-hydrolase
AYWB_RS02840	ENOG4108RWN	rrna methyltransferase
AYWB_RS02845	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
AYWB_RS02855	ENOG4105C8N	cysteinyl-tRNA synthetase
AYWB_RS02860	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
AYWB_RS02865	ENOG4108UJD	30S ribosomal protein S9
AYWB_RS02870	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
AYWB_RS02885	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
AYWB_RS02890	ENOG4105X0R	protein from nitrogen regulatory protein P-II
AYWB_RS02905	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
AYWB_RS02910	ENOG4105C34	Pseudouridine synthase
AYWB_RS02915	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
AYWB_RS02920	ENOG4107THF	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
AYWB_RS02925	ENOG4105C9M	aspartyl-trna synthetase
AYWB_RS02930	ENOG4107R36	histidyl-tRNA synthetase
AYWB_RS02935	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
AYWB_RS02940	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
AYWB_RS02955	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
AYWB_RS02960	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
AYWB_RS02970	ENOG410848Y	50S ribosomal protein l28
AYWB_RS02975	ENOG41082DI	50s ribosomal protein l31
AYWB_RS02980	ENOG4107T8J	thymidine kinase
AYWB_RS02985	ENOG4108Z6B	deaminase
AYWB_RS02990	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
AYWB_RS02995	ENOG4105EQI	Metal Dependent Phosphohydrolase
AYWB_RS03040	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
AYWB_RS03050	ENOG4107RBD	ABC, transporter
AYWB_RS03055	ENOG4105CC5	ABC transporter
AYWB_RS03060	ENOG4105DIK	(ABC) transporter
AYWB_RS03065	ENOG4105DSE	periplasmic solute binding protein
AYWB_RS03075	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AYWB_RS03090	ENOG4107Y7S	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
AYWB_RS03095	ENOG4105C72	UPF0176 protein
AYWB_RS03105	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
AYWB_RS03110	ENOG41082YS	Binds directly to 16S ribosomal RNA
AYWB_RS03120	ENOG4105E5Q	amino acid AbC transporter
AYWB_RS03160	ENOG4108VPX	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity)
AYWB_RS03165	ENOG4105DCI	Phosphohydrolase
AYWB_RS03170	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
AYWB_RS03175	ENOG4105K4W	Could be involved in septation (By similarity)
AYWB_RS03180	ENOG4105C59	p-type ATPase
AYWB_RS03195	ENOG4105ZAD	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
AYWB_RS03200	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
AYWB_RS03205	ENOG4105C8T	Leucyl-tRNA synthetase
AYWB_RS03210	ENOG41084E5	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
AYWB_RS03215	ENOG4105CN9	Peptidase m42 family protein
AYWB_RS03225	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
AYWB_RS03235	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
AYWB_RS03245	ENOG4105C22	threonyL-tRNA synthetase
AYWB_RS03250	ENOG4105SFS	phosphoesterase RecJ domain protein
AYWB_RS03255	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
AYWB_RS03275	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
AYWB_RS03280	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
AYWB_RS03285	ENOG4105C5S	asparaginyl-tRNA synthetase
AYWB_RS03420	ENOG4105C19	ABC transporter
AYWB_RS03635	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)