locus-tag	class	description
ASTEX_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ASTEX_RS00030	COG4948	Mandelate Racemase Muconate Lactonizing
ASTEX_RS00045	COG1959	2 iron, 2 sulfur cluster binding
ASTEX_RS00050	COG4221	oxidoreductase activity
ASTEX_RS00055	COG2095	MarC family integral membrane protein
ASTEX_RS00060	COG0284	orotidine-5'-phosphate decarboxylase activity
ASTEX_RS00065	COG5508	conserved small protein
ASTEX_RS00070	COG0501	Belongs to the peptidase M48B family
ASTEX_RS00080	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ASTEX_RS00090	COG0138	bifunctional purine biosynthesis protein purh
ASTEX_RS00110	COG0180	Tryptophanyl-tRNA synthetase
ASTEX_RS00115	COG0728	peptidoglycan biosynthetic process
ASTEX_RS00130	COG1487	ribonuclease activity
ASTEX_RS00155	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ASTEX_RS00160	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ASTEX_RS00165	COG0281	malic enzyme
ASTEX_RS00165	COG0280	phosphate acetyltransferase
ASTEX_RS00170	COG2807	transmembrane transport
ASTEX_RS00175	COG2205	protein histidine kinase activity
ASTEX_RS00175	COG5002	protein histidine kinase activity
ASTEX_RS00175	COG0784	Response regulator, receiver
ASTEX_RS00185	COG1538	Outer membrane efflux protein
ASTEX_RS00190	COG0577	efflux transmembrane transporter activity
ASTEX_RS00190	COG1136	(ABC) transporter
ASTEX_RS00195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASTEX_RS00205	COG0189	ligase activity
ASTEX_RS00210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ASTEX_RS00220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ASTEX_RS00225	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ASTEX_RS00235	COG3655	Transcriptional regulator
ASTEX_RS00240	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ASTEX_RS00265	COG0412	Dienelactone hydrolase
ASTEX_RS00270	COG0443	Heat shock 70 kDa protein
ASTEX_RS00275	COG0484	heat shock protein binding
ASTEX_RS00280	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ASTEX_RS00290	COG0756	dUTP diphosphatase activity
ASTEX_RS00305	COG5001	Diguanylate cyclase
ASTEX_RS00310	COG0598	Magnesium transport protein CorA
ASTEX_RS00315	COG2972	Histidine kinase
ASTEX_RS00315	COG0840	transmembrane signaling receptor activity
ASTEX_RS00320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ASTEX_RS00325	COG2226	methyltransferase
ASTEX_RS00340	COG3328	transposase activity
ASTEX_RS00380	COG0802	atpase or kinase
ASTEX_RS00385	COG3178	'Phosphotransferase
ASTEX_RS00390	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ASTEX_RS00400	COG1074	ATP-dependent DNA helicase activity
ASTEX_RS00410	COG1597	lipid kinase activity
ASTEX_RS00415	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ASTEX_RS00425	COG3047	cAMP biosynthetic process
ASTEX_RS00435	COG1674	ftsk spoiiie
ASTEX_RS00440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASTEX_RS00445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ASTEX_RS00470	COG3250	beta-galactosidase activity
ASTEX_RS00475	COG1940	carbohydrate kinase activity
ASTEX_RS00475	COG1846	Transcriptional regulator
ASTEX_RS00495	COG0583	DNA-binding transcription factor activity
ASTEX_RS00500	COG1028	Short-chain dehydrogenase reductase Sdr
ASTEX_RS00510	COG1695	Transcriptional regulator
ASTEX_RS00525	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ASTEX_RS00535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASTEX_RS00550	COG0071	Belongs to the small heat shock protein (HSP20) family
ASTEX_RS00555	COG0427	acetyl-CoA hydrolase
ASTEX_RS00560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASTEX_RS00565	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ASTEX_RS00570	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ASTEX_RS00575	COG1137	ATPase activity
ASTEX_RS00590	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ASTEX_RS00595	COG0477	Major facilitator Superfamily
ASTEX_RS00620	COG0745	RESPONSE REGULATOR receiver
ASTEX_RS00635	COG0352	thiamine-phosphate diphosphorylase activity
ASTEX_RS00685	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ASTEX_RS00695	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ASTEX_RS00700	COG1981	membrane
ASTEX_RS00705	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ASTEX_RS00715	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ASTEX_RS00720	COG0424	maF-like protein
ASTEX_RS00730	COG0237	dephospho-CoA kinase activity
ASTEX_RS00735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ASTEX_RS00740	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ASTEX_RS00750	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ASTEX_RS00765	COG0433	COG0433 Predicted ATPase
ASTEX_RS00780	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ASTEX_RS00805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASTEX_RS00810	COG1702	phosphate starvation-inducible protein PhoH
ASTEX_RS00815	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ASTEX_RS00820	COG1253	flavin adenine dinucleotide binding
ASTEX_RS00825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ASTEX_RS00830	COG1396	sequence-specific DNA binding
ASTEX_RS00835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ASTEX_RS00850	COG0779	Required for maturation of 30S ribosomal subunits
ASTEX_RS00865	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ASTEX_RS00865	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ASTEX_RS00900	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ASTEX_RS00910	COG1185	polyribonucleotide nucleotidyltransferase activity
ASTEX_RS00925	COG2133	pyrroloquinoline quinone binding
ASTEX_RS00930	COG0335	large ribosomal subunit rRNA binding
ASTEX_RS00935	COG0336	Belongs to the RNA methyltransferase TrmD family
ASTEX_RS00940	COG4771	TonB-dependent receptor
ASTEX_RS00945	COG0745	RESPONSE REGULATOR receiver
ASTEX_RS00950	COG2373	Large extracellular alpha-helical protein
ASTEX_RS00955	COG4953	penicillin-binding protein 1C
ASTEX_RS00960	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ASTEX_RS00975	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ASTEX_RS00990	COG0436	Aminotransferase
ASTEX_RS01015	COG2009	succinate dehydrogenase
ASTEX_RS01025	COG1053	succinate dehydrogenase
ASTEX_RS01030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ASTEX_RS01035	COG0633	Ferredoxin
ASTEX_RS01040	COG2239	Acts as a magnesium transporter
ASTEX_RS01050	COG2205	protein histidine kinase activity
ASTEX_RS01060	COG0640	Transcriptional regulator
ASTEX_RS01070	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ASTEX_RS01080	COG1999	signal sequence binding
ASTEX_RS01085	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ASTEX_RS01125	COG2353	YceI-like domain
ASTEX_RS01145	COG2814	Major facilitator Superfamily
ASTEX_RS01150	COG0045	succinate-CoA ligase (ADP-forming) activity
ASTEX_RS01155	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ASTEX_RS01185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASTEX_RS01205	COG1749	Flagellar hook protein flgE
ASTEX_RS01245	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ASTEX_RS01265	COG1253	flavin adenine dinucleotide binding
ASTEX_RS01275	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ASTEX_RS01280	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ASTEX_RS01285	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ASTEX_RS01290	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ASTEX_RS01295	COG0840	transmembrane signaling receptor activity
ASTEX_RS01310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASTEX_RS01315	COG0552	protein localization to endoplasmic reticulum
ASTEX_RS01320	COG2917	probably involved in intracellular septation
ASTEX_RS01335	COG1028	Short-chain dehydrogenase reductase Sdr
ASTEX_RS01340	COG3639	organic phosphonate transmembrane transporter activity
ASTEX_RS01345	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ASTEX_RS01350	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ASTEX_RS01375	COG1899	peptidyl-lysine modification to peptidyl-hypusine
ASTEX_RS01380	COG0657	acetylesterase activity
ASTEX_RS01380	COG2755	lipolytic protein G-D-S-L family
ASTEX_RS01390	COG1309	transcriptional regulator
ASTEX_RS01405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASTEX_RS01420	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ASTEX_RS01425	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ASTEX_RS01430	COG5507	3-demethylubiquinone-9 3-methyltransferase
ASTEX_RS01435	COG5507	3-demethylubiquinone-9 3-methyltransferase
ASTEX_RS01515	COG0629	single-stranded DNA binding
ASTEX_RS01610	COG4695	Portal protein
ASTEX_RS01615	COG0740	serine-type endopeptidase activity
ASTEX_RS01720	COG0202	RNA polymerase activity
ASTEX_RS01755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ASTEX_RS01780	COG2124	cytochrome p450
ASTEX_RS01790	COG2205	protein histidine kinase activity
ASTEX_RS01795	COG3401	FG-GAP repeat protein
ASTEX_RS01825	COG2801	Transposase and inactivated derivatives
ASTEX_RS01830	COG0670	Belongs to the BI1 family
ASTEX_RS01835	COG2301	Belongs to the HpcH HpaI aldolase family
ASTEX_RS01845	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ASTEX_RS01855	COG0745	RESPONSE REGULATOR receiver
ASTEX_RS01860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ASTEX_RS01885	COG1073	alpha beta
ASTEX_RS01895	COG0303	'Molybdopterin
ASTEX_RS01900	COG0521	Mo-molybdopterin cofactor biosynthetic process
ASTEX_RS01905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ASTEX_RS01910	COG2272	Belongs to the type-B carboxylesterase lipase family
ASTEX_RS01930	COG2186	Transcriptional regulator
ASTEX_RS01945	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ASTEX_RS01950	COG0799	negative regulation of ribosome biogenesis
ASTEX_RS01955	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ASTEX_RS01960	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASTEX_RS01975	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ASTEX_RS01980	COG0523	cobalamin synthesis protein
ASTEX_RS02015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ASTEX_RS02020	COG2885	chlorophyll binding
ASTEX_RS02030	COG1086	Polysaccharide biosynthesis protein
ASTEX_RS02035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ASTEX_RS02040	COG2089	acid synthase
ASTEX_RS02075	COG4964	Belongs to the GSP D family
ASTEX_RS02120	COG0793	Belongs to the peptidase S41A family
ASTEX_RS02140	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ASTEX_RS02155	COG0077	Prephenate dehydratase
ASTEX_RS02155	COG1605	Chorismate mutase
ASTEX_RS02170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ASTEX_RS02175	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ASTEX_RS02180	COG4133	protoheme IX ABC transporter activity
ASTEX_RS02185	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ASTEX_RS02210	COG1904	glucuronate isomerase
ASTEX_RS02215	COG1609	Transcriptional regulator
ASTEX_RS02220	COG2721	sulfolactate sulfo-lyase activity
ASTEX_RS02225	COG0246	Mannitol dehydrogenase
ASTEX_RS02230	COG1396	sequence-specific DNA binding
ASTEX_RS02230	COG3800	Transcriptional regulator
ASTEX_RS02245	COG2224	Isocitrate lyase
ASTEX_RS02265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ASTEX_RS02265	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ASTEX_RS02300	COG0745	RESPONSE REGULATOR receiver
ASTEX_RS02305	COG2205	protein histidine kinase activity
ASTEX_RS02310	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ASTEX_RS02315	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ASTEX_RS02315	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASTEX_RS02320	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ASTEX_RS02320	COG2169	Transcriptional regulator
ASTEX_RS02345	COG0121	glutamine amidotransferase
ASTEX_RS02350	COG1764	response to oxidative stress
ASTEX_RS02380	COG0730	response to heat
ASTEX_RS02395	COG1199	ATP-dependent helicase activity
ASTEX_RS02400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ASTEX_RS02415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ASTEX_RS02425	COG1309	transcriptional regulator
ASTEX_RS02455	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASTEX_RS02465	COG2311	Membrane
ASTEX_RS02470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ASTEX_RS02475	COG0165	Argininosuccinate lyase
ASTEX_RS02485	COG0019	diaminopimelate decarboxylase activity
ASTEX_RS02505	COG0840	transmembrane signaling receptor activity
ASTEX_RS02510	COG2967	ApaG domain
ASTEX_RS02515	COG0717	Belongs to the dCTP deaminase family
ASTEX_RS02560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ASTEX_RS02565	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ASTEX_RS02570	COG0612	Peptidase, M16
ASTEX_RS02580	COG1462	curli production assembly transport component CsgG
ASTEX_RS02635	COG3328	transposase activity
ASTEX_RS02645	COG2184	nucleotidyltransferase activity
ASTEX_RS02655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ASTEX_RS02680	COG3540	Alkaline phosphatase
ASTEX_RS02690	COG1737	Transcriptional regulator
ASTEX_RS02695	COG3328	transposase activity
ASTEX_RS02700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASTEX_RS02735	COG1335	isochorismatase
ASTEX_RS02740	COG0753	catalase activity
ASTEX_RS02750	COG4566	intracellular signal transduction
ASTEX_RS02755	COG4191	Histidine kinase
ASTEX_RS02760	COG4566	intracellular signal transduction
ASTEX_RS02765	COG3328	transposase activity
ASTEX_RS02830	COG0745	RESPONSE REGULATOR receiver
ASTEX_RS02870	COG0438	transferase activity, transferring glycosyl groups
ASTEX_RS02875	COG1522	sequence-specific DNA binding
ASTEX_RS02895	COG0482	sulfurtransferase activity
ASTEX_RS02920	COG1749	Flagellar hook protein flgE
ASTEX_RS02930	COG1766	The M ring may be actively involved in energy transduction
ASTEX_RS02935	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ASTEX_RS02945	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ASTEX_RS02950	COG2204	response regulator
ASTEX_RS02960	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ASTEX_RS03030	COG2201	protein-glutamate methylesterase activity
ASTEX_RS03035	COG0643	Histidine kinase
ASTEX_RS03035	COG0784	Response regulator, receiver
ASTEX_RS03035	COG2198	Histidine kinase
ASTEX_RS03045	COG2198	Histidine kinase
ASTEX_RS03045	COG0784	Response regulator, receiver
ASTEX_RS03045	COG0643	Histidine kinase
ASTEX_RS03080	COG2166	iron-sulfur cluster assembly
ASTEX_RS03085	COG2202	Pas domain
ASTEX_RS03085	COG2205	protein histidine kinase activity
ASTEX_RS03090	COG2205	protein histidine kinase activity
ASTEX_RS03110	COG2814	Major facilitator Superfamily
ASTEX_RS03115	COG1272	protein, Hemolysin III
ASTEX_RS03120	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ASTEX_RS03155	COG0471	metal ion transport
ASTEX_RS03155	COG3273	potassium ion transport
ASTEX_RS03165	COG3507	Belongs to the glycosyl hydrolase 43 family
ASTEX_RS03180	COG2271	Major facilitator Superfamily
ASTEX_RS03185	COG3507	Belongs to the glycosyl hydrolase 43 family
ASTEX_RS03215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASTEX_RS03220	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASTEX_RS03235	COG0745	RESPONSE REGULATOR receiver
ASTEX_RS03240	COG2205	protein histidine kinase activity
ASTEX_RS03245	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ASTEX_RS03250	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ASTEX_RS03255	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ASTEX_RS03290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ASTEX_RS03295	COG3577	Aspartyl protease
ASTEX_RS03320	COG0556	nucleotide-excision repair
ASTEX_RS03345	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ASTEX_RS03355	COG0492	ferredoxin-NADP+ reductase activity
ASTEX_RS03390	COG0640	Transcriptional regulator
ASTEX_RS03400	COG2154	pterin-4-alpha-carbinolamine dehydratase
ASTEX_RS03405	COG3186	Phenylalanine-4-hydroxylase
ASTEX_RS03430	COG2205	protein histidine kinase activity
ASTEX_RS03440	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ASTEX_RS03445	COG0784	Response regulator, receiver
ASTEX_RS03445	COG2198	Histidine kinase
ASTEX_RS03445	COG2205	protein histidine kinase activity
ASTEX_RS03455	COG0018	arginyl-trna synthetase
ASTEX_RS03460	COG3634	alkyl hydroperoxide reductase activity
ASTEX_RS03465	COG0450	alkyl hydroperoxide reductase
ASTEX_RS03505	COG0473	3-isopropylmalate dehydrogenase activity
ASTEX_RS03510	COG0066	3-isopropylmalate dehydratase activity
ASTEX_RS03515	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ASTEX_RS03525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ASTEX_RS03540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ASTEX_RS03550	COG0129	dihydroxy-acid dehydratase activity
ASTEX_RS03575	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ASTEX_RS03580	COG3162	membrane
ASTEX_RS03600	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ASTEX_RS03605	COG3552	Protein containing von Willebrand factor type A (VWA) domain
ASTEX_RS03610	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ASTEX_RS03615	COG0714	Associated with various cellular activities
ASTEX_RS03630	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ASTEX_RS03635	COG1690	Belongs to the RtcB family
ASTEX_RS03650	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ASTEX_RS03685	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ASTEX_RS03690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ASTEX_RS03705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASTEX_RS03750	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ASTEX_RS03760	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ASTEX_RS03775	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ASTEX_RS03795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ASTEX_RS03815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASTEX_RS03835	COG0189	ligase activity
ASTEX_RS03835	COG4067	protein conserved in archaea
ASTEX_RS03865	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ASTEX_RS03875	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ASTEX_RS03885	COG1073	alpha beta
ASTEX_RS03895	COG3384	dioxygenase
ASTEX_RS03900	COG2353	YceI-like domain
ASTEX_RS03905	COG4771	TonB-dependent receptor
ASTEX_RS03945	COG0625	glutathione transferase activity
ASTEX_RS03950	COG0442	prolyl-tRNA aminoacylation
ASTEX_RS03965	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ASTEX_RS03970	COG0385	Bile acid
ASTEX_RS03985	COG4948	Mandelate Racemase Muconate Lactonizing
ASTEX_RS04020	COG0107	imidazoleglycerol-phosphate synthase activity
ASTEX_RS04030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ASTEX_RS04045	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ASTEX_RS04060	COG0443	Heat shock 70 kDa protein
ASTEX_RS04075	COG1176	ABC-type spermidine putrescine transport system, permease component I
ASTEX_RS04080	COG1177	transmembrane transport
ASTEX_RS04085	COG3842	ATPase activity
ASTEX_RS04090	COG0114	fumarate hydratase activity
ASTEX_RS04115	COG1132	(ABC) transporter
ASTEX_RS04135	COG0463	Glycosyl transferase, family 2
ASTEX_RS04150	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
ASTEX_RS04160	COG1028	Short-chain dehydrogenase reductase Sdr
ASTEX_RS04170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASTEX_RS04185	COG0167	dihydroorotate dehydrogenase activity
ASTEX_RS04195	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ASTEX_RS04200	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
ASTEX_RS04205	COG4786	Flagellar basal body rod
ASTEX_RS04210	COG4786	Flagellar basal body rod
ASTEX_RS04220	COG1136	(ABC) transporter
ASTEX_RS04240	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ASTEX_RS04255	COG0783	Belongs to the Dps family
ASTEX_RS04270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ASTEX_RS04275	COG0436	Aminotransferase
ASTEX_RS04320	COG2885	chlorophyll binding
ASTEX_RS04325	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ASTEX_RS04335	COG2957	Belongs to the agmatine deiminase family
ASTEX_RS04345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ASTEX_RS04350	COG0840	transmembrane signaling receptor activity
ASTEX_RS04370	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ASTEX_RS04375	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ASTEX_RS04390	COG1322	Protein conserved in bacteria
ASTEX_RS04405	COG0242	peptide deformylase activity
ASTEX_RS04415	COG0101	tRNA pseudouridine synthase activity
ASTEX_RS04450	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ASTEX_RS04450	COG2755	lipolytic protein G-D-S-L family
ASTEX_RS04460	COG0598	Magnesium transport protein CorA
ASTEX_RS04475	COG4206	TonB-dependent receptor
ASTEX_RS04480	COG3328	transposase activity
ASTEX_RS04500	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ASTEX_RS04505	COG5001	Diguanylate cyclase
ASTEX_RS04515	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ASTEX_RS04530	COG0588	phosphoglycerate mutase activity
ASTEX_RS04550	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ASTEX_RS04565	COG1294	oxidase, subunit
ASTEX_RS04575	COG1086	Polysaccharide biosynthesis protein
ASTEX_RS04585	COG0314	molybdopterin synthase activity
ASTEX_RS04590	COG0315	cyclic pyranopterin monophosphate synthase activity
ASTEX_RS04595	COG2264	protein methyltransferase activity
ASTEX_RS04605	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ASTEX_RS04630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ASTEX_RS04645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASTEX_RS04660	COG0051	transcription antitermination factor activity, RNA binding
ASTEX_RS04665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ASTEX_RS04680	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ASTEX_RS04685	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ASTEX_RS04690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ASTEX_RS04695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ASTEX_RS04710	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ASTEX_RS04715	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ASTEX_RS04730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ASTEX_RS04745	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ASTEX_RS04750	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ASTEX_RS04760	COG0200	Binds to the 23S rRNA
ASTEX_RS04765	COG0201	protein transport
ASTEX_RS04770	COG0563	adenylate kinase activity
ASTEX_RS04780	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ASTEX_RS04790	COG0203	ribosomal protein L17
ASTEX_RS04820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ASTEX_RS04830	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ASTEX_RS04870	COG1956	GAF domain-containing protein
ASTEX_RS04885	COG0823	Involved in the tonB-independent uptake of proteins
ASTEX_RS04885	COG1506	peptidase
ASTEX_RS04905	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ASTEX_RS04915	COG4771	TonB-dependent receptor
ASTEX_RS04930	COG0318	PFAM AMP-dependent synthetase and ligase
ASTEX_RS04950	COG3237	CsbD-like
ASTEX_RS04970	COG1028	Short-chain dehydrogenase reductase Sdr
ASTEX_RS05000	COG1994	Peptidase M50
ASTEX_RS05005	COG0840	transmembrane signaling receptor activity
ASTEX_RS05015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ASTEX_RS05020	COG0174	glutamine synthetase
ASTEX_RS05035	COG3345	alpha-galactosidase
ASTEX_RS05045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASTEX_RS05060	COG2079	MmgE PrpD family protein
ASTEX_RS05100	COG1136	(ABC) transporter
ASTEX_RS05105	COG0523	cobalamin synthesis protein
ASTEX_RS05115	COG3540	Alkaline phosphatase
ASTEX_RS05150	COG2873	o-acetylhomoserine
ASTEX_RS05160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ASTEX_RS05175	COG1858	cytochrome C peroxidase
ASTEX_RS05230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ASTEX_RS05240	COG0431	NADPH-dependent FMN reductase
ASTEX_RS05280	COG1595	DNA-templated transcription, initiation
ASTEX_RS05305	COG0494	nUDIX hydrolase
ASTEX_RS05315	COG0702	epimerase
ASTEX_RS05320	COG1733	regulation of RNA biosynthetic process
ASTEX_RS05325	COG0800	Aldolase
ASTEX_RS05330	COG3734	2-keto-3-deoxy-galactonokinase
ASTEX_RS05335	COG3386	PFAM SMP-30 Gluconolaconase
ASTEX_RS05340	COG0183	Belongs to the thiolase family
ASTEX_RS05345	COG1024	Enoyl-CoA hydratase
ASTEX_RS05345	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASTEX_RS05350	COG0400	carboxylic ester hydrolase activity
ASTEX_RS05395	COG0753	catalase activity
ASTEX_RS05420	COG0387	Pfam Sodium calcium exchanger
ASTEX_RS05430	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ASTEX_RS05475	COG0670	Belongs to the BI1 family
ASTEX_RS05480	COG2205	protein histidine kinase activity
ASTEX_RS05500	COG2239	Acts as a magnesium transporter
ASTEX_RS05515	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ASTEX_RS05520	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ASTEX_RS05530	COG0356	it plays a direct role in the translocation of protons across the membrane
ASTEX_RS05555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ASTEX_RS05565	COG1194	a g-specific adenine glycosylase
ASTEX_RS05585	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ASTEX_RS05600	COG0354	folic acid binding
ASTEX_RS05610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ASTEX_RS05620	COG1024	Enoyl-CoA hydratase
ASTEX_RS05635	COG0617	tRNA 3'-terminal CCA addition
ASTEX_RS05640	COG0519	Catalyzes the synthesis of GMP from XMP
ASTEX_RS05640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ASTEX_RS05645	COG0408	coproporphyrinogen oxidase activity
ASTEX_RS05650	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ASTEX_RS05655	COG0723	plastoquinol--plastocyanin reductase activity
ASTEX_RS05665	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ASTEX_RS05665	COG2857	Cytochrome c1
ASTEX_RS05670	COG1418	mRNA catabolic process
ASTEX_RS05680	COG0012	GTP binding
ASTEX_RS05690	COG1819	glycosyl
ASTEX_RS05695	COG0193	aminoacyl-tRNA hydrolase activity
ASTEX_RS05700	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ASTEX_RS05730	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ASTEX_RS05765	COG1846	Transcriptional regulator
ASTEX_RS05770	COG1764	response to oxidative stress
ASTEX_RS05775	COG0667	Aldo Keto reductase
ASTEX_RS05785	COG0626	cystathionine gamma-synthase activity
ASTEX_RS05810	COG0460	homoserine dehydrogenase
ASTEX_RS05815	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ASTEX_RS05835	COG0564	pseudouridine synthase activity
ASTEX_RS05850	COG3152	Membrane
ASTEX_RS05860	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ASTEX_RS05875	COG0393	Putative heavy-metal-binding
ASTEX_RS05910	COG5328	Belongs to the UPF0262 family
ASTEX_RS05920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ASTEX_RS05925	COG0424	maF-like protein
ASTEX_RS05935	COG0459	protein refolding
ASTEX_RS05975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ASTEX_RS05995	COG0714	Associated with various cellular activities
ASTEX_RS06020	COG0784	Response regulator, receiver
ASTEX_RS06020	COG4191	Histidine kinase
ASTEX_RS06025	COG1609	Transcriptional regulator
ASTEX_RS06055	COG2211	Major facilitator Superfamily
ASTEX_RS06060	COG1462	curli production assembly transport component CsgG
ASTEX_RS06065	COG1462	curli production assembly transport component CsgG
ASTEX_RS06080	COG3250	beta-galactosidase activity
ASTEX_RS06085	COG3250	beta-galactosidase activity
ASTEX_RS06120	COG0531	amino acid
ASTEX_RS06125	COG1116	anion transmembrane transporter activity
ASTEX_RS06130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ASTEX_RS06135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ASTEX_RS06150	COG1862	Preprotein translocase
ASTEX_RS06170	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ASTEX_RS06185	COG3338	carbonate dehydratase activity
ASTEX_RS06190	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ASTEX_RS06210	COG1706	bacterial-type flagellum-dependent cell motility
ASTEX_RS06255	COG0616	signal peptide processing
ASTEX_RS06260	COG1054	Belongs to the UPF0176 family
ASTEX_RS06295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ASTEX_RS06310	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ASTEX_RS06315	COG0454	-acetyltransferase
ASTEX_RS06325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ASTEX_RS06330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ASTEX_RS06335	COG1522	sequence-specific DNA binding
ASTEX_RS06355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASTEX_RS06360	COG1309	transcriptional regulator
ASTEX_RS06370	COG0673	inositol 2-dehydrogenase activity
ASTEX_RS06405	COG1217	gtp-binding protein TYPA
ASTEX_RS06430	COG3128	pkhd-type hydroxylase
ASTEX_RS06450	COG1477	protein flavinylation
ASTEX_RS06465	COG3046	protein related to deoxyribodipyrimidine photolyase
ASTEX_RS06475	COG4771	TonB-dependent receptor
ASTEX_RS06480	COG0457	Tetratricopeptide repeat
ASTEX_RS06495	COG2755	lipolytic protein G-D-S-L family
ASTEX_RS06495	COG0657	acetylesterase activity
ASTEX_RS06520	COG3459	Glycosyltransferase 36 associated
ASTEX_RS06525	COG3682	Transcriptional regulator
ASTEX_RS06565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASTEX_RS06590	COG0667	Aldo Keto reductase
ASTEX_RS06595	COG1473	amidohydrolase
ASTEX_RS06600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ASTEX_RS06610	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ASTEX_RS06630	COG3451	type IV secretory pathway VirB4
ASTEX_RS06645	COG0741	lytic transglycosylase activity
ASTEX_RS06665	COG2132	Multicopper oxidase
ASTEX_RS06680	COG1609	Transcriptional regulator
ASTEX_RS06685	COG0477	Major facilitator Superfamily
ASTEX_RS06695	COG0784	Response regulator, receiver
ASTEX_RS06695	COG2205	protein histidine kinase activity
ASTEX_RS06715	COG0805	protein transport
ASTEX_RS06725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASTEX_RS06730	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ASTEX_RS06735	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ASTEX_RS06740	COG1472	Belongs to the glycosyl hydrolase 3 family
ASTEX_RS06760	COG1793	dna ligase
ASTEX_RS06765	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ASTEX_RS06765	COG1793	dna ligase
ASTEX_RS06770	COG1201	RNA secondary structure unwinding
ASTEX_RS06785	COG0583	DNA-binding transcription factor activity
ASTEX_RS06820	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ASTEX_RS06830	COG1472	Belongs to the glycosyl hydrolase 3 family
ASTEX_RS06840	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ASTEX_RS06880	COG2755	lipolytic protein G-D-S-L family
ASTEX_RS06920	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ASTEX_RS06930	COG0321	lipoyl(octanoyl) transferase activity
ASTEX_RS06945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASTEX_RS06950	COG1278	Cold shock
ASTEX_RS06960	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ASTEX_RS06970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ASTEX_RS06975	COG0142	geranyltranstransferase activity
ASTEX_RS06990	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ASTEX_RS07005	COG1595	DNA-templated transcription, initiation
ASTEX_RS07020	COG1501	Belongs to the glycosyl hydrolase 31 family
ASTEX_RS07030	COG2186	Transcriptional regulator
ASTEX_RS07045	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ASTEX_RS07050	COG1684	flagellar biosynthetic protein fliR
ASTEX_RS07055	COG1987	bacterial-type flagellum assembly
ASTEX_RS07060	COG1677	Flagellar hook-basal body complex protein FliE
ASTEX_RS07065	COG1558	bacterial-type flagellum-dependent cell motility
ASTEX_RS07075	COG3190	flagellar
ASTEX_RS07080	COG1338	Plays a role in the flagellum-specific transport system
ASTEX_RS07095	COG3609	addiction module antidote protein, CC2985 family
ASTEX_RS07130	COG3328	transposase activity
ASTEX_RS07160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ASTEX_RS07175	COG0842	Transport permease protein
ASTEX_RS07180	COG1131	(ABC) transporter
ASTEX_RS07190	COG1309	transcriptional regulator
ASTEX_RS07205	COG2267	carboxylic ester hydrolase activity
ASTEX_RS07225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ASTEX_RS07235	COG0753	catalase activity
ASTEX_RS07245	COG2824	Alkylphosphonate utilization operon protein PhnA
ASTEX_RS07255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ASTEX_RS07270	COG2205	protein histidine kinase activity
ASTEX_RS07270	COG2198	Histidine kinase
ASTEX_RS07270	COG0784	Response regulator, receiver
ASTEX_RS07275	COG4206	TonB-dependent receptor
ASTEX_RS07295	COG1309	transcriptional regulator
ASTEX_RS07320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ASTEX_RS07360	COG3727	T/G mismatch-specific endonuclease activity
ASTEX_RS07415	COG1058	Belongs to the CinA family
ASTEX_RS07415	COG1546	Belongs to the CinA family
ASTEX_RS07420	COG1489	DNA binding
ASTEX_RS07425	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ASTEX_RS07425	COG0392	lysyltransferase activity
ASTEX_RS07435	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ASTEX_RS07490	COG1742	UPF0060 membrane protein
ASTEX_RS07495	COG0534	Mate efflux family protein
ASTEX_RS07510	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ASTEX_RS07525	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ASTEX_RS07535	COG0546	phosphoglycolate phosphatase activity
ASTEX_RS07545	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ASTEX_RS07545	COG0475	glutathione-regulated potassium exporter activity
ASTEX_RS07555	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ASTEX_RS07585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ASTEX_RS07610	COG0642	Histidine kinase
ASTEX_RS07625	COG2022	thiamine diphosphate biosynthetic process
ASTEX_RS07625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ASTEX_RS07655	COG0848	biopolymer transport protein
ASTEX_RS07665	COG2951	lytic endotransglycosylase activity
ASTEX_RS07685	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ASTEX_RS07705	COG2204	response regulator
ASTEX_RS07725	COG3739	integral membrane protein
ASTEX_RS07745	COG2801	Transposase and inactivated derivatives
ASTEX_RS07760	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ASTEX_RS07760	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ASTEX_RS07770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ASTEX_RS07790	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ASTEX_RS07795	COG0328	RNA-DNA hybrid ribonuclease activity
ASTEX_RS07815	COG1702	phosphate starvation-inducible protein PhoH
ASTEX_RS07845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ASTEX_RS07855	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ASTEX_RS07860	COG0745	RESPONSE REGULATOR receiver
ASTEX_RS07895	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ASTEX_RS07905	COG2264	protein methyltransferase activity
ASTEX_RS07925	COG1396	sequence-specific DNA binding
ASTEX_RS07930	COG0483	inositol monophosphate 1-phosphatase activity
ASTEX_RS07955	COG1472	Belongs to the glycosyl hydrolase 3 family
ASTEX_RS07960	COG3047	cAMP biosynthetic process
ASTEX_RS07965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASTEX_RS07965	COG0425	Belongs to the sulfur carrier protein TusA family
ASTEX_RS07980	COG0322	excinuclease ABC activity
ASTEX_RS07995	COG1028	Short-chain dehydrogenase reductase Sdr
ASTEX_RS08000	COG0142	geranyltranstransferase activity
ASTEX_RS08005	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ASTEX_RS08010	COG0542	response to heat
ASTEX_RS08030	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ASTEX_RS08035	COG0438	transferase activity, transferring glycosyl groups
ASTEX_RS08100	COG0772	Belongs to the SEDS family
ASTEX_RS08105	COG0768	penicillin binding
ASTEX_RS08130	COG0217	transcriptional regulatory protein
ASTEX_RS08135	COG1692	metallophosphoesterase
ASTEX_RS08145	COG0861	Integral membrane protein TerC family
ASTEX_RS08175	COG1278	Cold shock
ASTEX_RS08180	COG2813	Specifically methylates the guanine in position
ASTEX_RS08185	COG1187	pseudouridine synthase activity
ASTEX_RS08200	COG2205	protein histidine kinase activity
ASTEX_RS08220	COG0071	Belongs to the small heat shock protein (HSP20) family
ASTEX_RS08230	COG0626	cystathionine gamma-synthase activity
ASTEX_RS08235	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ASTEX_RS08245	COG4208	sulfate ABC transporter
ASTEX_RS08250	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ASTEX_RS08260	COG4221	oxidoreductase activity
ASTEX_RS08270	COG4206	TonB-dependent receptor
ASTEX_RS08280	COG0006	proline dipeptidase activity
ASTEX_RS08290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ASTEX_RS08295	COG0497	DNA recombination
ASTEX_RS08300	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ASTEX_RS08305	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ASTEX_RS08315	COG0849	cell division
ASTEX_RS08345	COG2885	chlorophyll binding
ASTEX_RS08350	COG0823	Involved in the tonB-independent uptake of proteins
ASTEX_RS08375	COG0632	four-way junction helicase activity
ASTEX_RS08380	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ASTEX_RS08410	COG0488	(ABC) transporter
ASTEX_RS08415	COG3300	MHYT domain
ASTEX_RS08415	COG5001	Diguanylate cyclase
ASTEX_RS08420	COG2188	Transcriptional regulator
ASTEX_RS08435	COG2971	BadF BadG BcrA BcrD
ASTEX_RS08440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ASTEX_RS08445	COG2885	chlorophyll binding
ASTEX_RS08475	COG0163	prenyltransferase activity
ASTEX_RS08515	COG0352	thiamine-phosphate diphosphorylase activity
ASTEX_RS08525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ASTEX_RS08530	COG0483	inositol monophosphate 1-phosphatase activity
ASTEX_RS08535	COG1309	transcriptional regulator
ASTEX_RS08540	COG0300	oxidoreductase activity
ASTEX_RS08545	COG1132	(ABC) transporter
ASTEX_RS08555	COG0387	Pfam Sodium calcium exchanger
ASTEX_RS08585	COG2171	N-acyltransferase activity
ASTEX_RS08595	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
ASTEX_RS08600	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ASTEX_RS08605	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ASTEX_RS08610	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ASTEX_RS08635	COG0489	protein tyrosine kinase activity
ASTEX_RS08640	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ASTEX_RS08655	COG0129	dihydroxy-acid dehydratase activity
ASTEX_RS08670	COG1012	belongs to the aldehyde dehydrogenase family
ASTEX_RS08720	COG2755	lipolytic protein G-D-S-L family
ASTEX_RS08720	COG0657	acetylesterase activity
ASTEX_RS08735	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ASTEX_RS08760	COG0215	cysteine-tRNA ligase activity
ASTEX_RS08765	COG0302	gtp cyclohydrolase
ASTEX_RS08770	COG0848	biopolymer transport protein
ASTEX_RS08775	COG0564	pseudouridine synthase activity
ASTEX_RS08785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASTEX_RS08820	COG0351	phosphomethylpyrimidine kinase
ASTEX_RS08840	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ASTEX_RS08845	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ASTEX_RS08850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ASTEX_RS08885	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ASTEX_RS08895	COG0174	glutamine synthetase
ASTEX_RS08900	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ASTEX_RS08905	COG1012	belongs to the aldehyde dehydrogenase family
ASTEX_RS08910	COG1012	belongs to the aldehyde dehydrogenase family
ASTEX_RS08925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ASTEX_RS08945	COG1230	cation diffusion facilitator family transporter
ASTEX_RS08985	COG1522	sequence-specific DNA binding
ASTEX_RS08990	COG0686	Belongs to the AlaDH PNT family
ASTEX_RS09045	COG0072	phenylalanine-tRNA ligase activity
ASTEX_RS09045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASTEX_RS09115	COG0494	nUDIX hydrolase
ASTEX_RS09135	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ASTEX_RS09155	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ASTEX_RS09160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ASTEX_RS09195	COG3023	N-Acetylmuramoyl-L-alanine amidase
ASTEX_RS09225	COG0006	proline dipeptidase activity
ASTEX_RS09265	COG2226	methyltransferase
ASTEX_RS09275	COG3422	double-strand break repair
ASTEX_RS09285	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ASTEX_RS09310	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ASTEX_RS09320	COG1959	2 iron, 2 sulfur cluster binding
ASTEX_RS09360	COG2308	Evidence 4 Homologs of previously reported genes of
ASTEX_RS09390	COG2272	Belongs to the type-B carboxylesterase lipase family
ASTEX_RS09395	COG1940	carbohydrate kinase activity
ASTEX_RS09420	COG0469	pyruvate kinase activity
ASTEX_RS09425	COG0295	cytidine deaminase activity
ASTEX_RS09435	COG0738	Major facilitator superfamily
ASTEX_RS09445	COG1414	Transcriptional regulator
ASTEX_RS09460	COG2721	sulfolactate sulfo-lyase activity
ASTEX_RS09465	COG1028	Short-chain dehydrogenase reductase Sdr
ASTEX_RS09480	COG0477	Major facilitator Superfamily
ASTEX_RS09480	COG2814	Major facilitator Superfamily
ASTEX_RS09485	COG0129	dihydroxy-acid dehydratase activity
ASTEX_RS09490	COG3386	PFAM SMP-30 Gluconolaconase
ASTEX_RS09530	COG0505	Belongs to the CarA family
ASTEX_RS09535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ASTEX_RS09550	COG1505	serine-type exopeptidase activity
ASTEX_RS09560	COG1414	Transcriptional regulator
ASTEX_RS09565	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ASTEX_RS09575	COG3250	beta-galactosidase activity
ASTEX_RS09595	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ASTEX_RS09610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ASTEX_RS09620	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ASTEX_RS09620	COG1918	ferrous iron import across plasma membrane
ASTEX_RS09635	COG2252	PERMEase
ASTEX_RS09665	COG1472	Belongs to the glycosyl hydrolase 3 family
ASTEX_RS09675	COG1609	Transcriptional regulator
ASTEX_RS09680	COG0800	Aldolase
ASTEX_RS09685	COG0837	glucose binding
ASTEX_RS09695	COG0363	glucosamine-6-phosphate deaminase activity
ASTEX_RS09700	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ASTEX_RS09705	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ASTEX_RS09720	COG0308	aminopeptidase N
ASTEX_RS09730	COG2202	Pas domain
ASTEX_RS09730	COG2205	protein histidine kinase activity
ASTEX_RS09735	COG0697	spore germination
ASTEX_RS09755	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ASTEX_RS09770	COG2205	protein histidine kinase activity
ASTEX_RS09785	COG1028	Short-chain dehydrogenase reductase Sdr
ASTEX_RS09790	COG5265	(ABC) transporter
ASTEX_RS09800	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ASTEX_RS09805	COG2819	hydrolase of the alpha beta superfamily
ASTEX_RS09825	COG1760	l-serine dehydratase
ASTEX_RS09860	COG1609	Transcriptional regulator
ASTEX_RS09880	COG5487	UPF0391 membrane protein
ASTEX_RS09890	COG1846	Transcriptional regulator
ASTEX_RS09895	COG2204	response regulator
ASTEX_RS09900	COG2205	protein histidine kinase activity
ASTEX_RS09910	COG0784	Response regulator, receiver
ASTEX_RS09910	COG2205	protein histidine kinase activity
ASTEX_RS09920	COG5002	protein histidine kinase activity
ASTEX_RS09950	COG2186	Transcriptional regulator
ASTEX_RS09955	COG1301	dicarboxylic acid transport
ASTEX_RS09970	COG2197	response regulator
ASTEX_RS09980	COG2346	COG2346, Truncated hemoglobins
ASTEX_RS09990	COG3088	subunit of a heme lyase
ASTEX_RS09995	COG1138	Cytochrome C-type biogenesis protein
ASTEX_RS10030	COG0484	heat shock protein binding
ASTEX_RS10035	COG2983	Belongs to the UPF0260 family
ASTEX_RS10040	COG0488	(ABC) transporter
ASTEX_RS10060	COG0583	DNA-binding transcription factor activity
ASTEX_RS10065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ASTEX_RS10070	COG1024	Enoyl-CoA hydratase
ASTEX_RS10075	COG0439	Biotin carboxylase
ASTEX_RS10080	COG1960	acyl-CoA dehydrogenase activity
ASTEX_RS10095	COG1024	Enoyl-CoA hydratase
ASTEX_RS10110	COG1522	sequence-specific DNA binding
ASTEX_RS10150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASTEX_RS10155	COG0028	Belongs to the TPP enzyme family
ASTEX_RS10160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ASTEX_RS10165	COG1960	acyl-CoA dehydrogenase activity
ASTEX_RS10170	COG1012	belongs to the aldehyde dehydrogenase family
ASTEX_RS10175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ASTEX_RS10220	COG1609	Transcriptional regulator
ASTEX_RS10255	COG0583	DNA-binding transcription factor activity
ASTEX_RS10260	COG0667	Aldo Keto reductase
ASTEX_RS10275	COG0583	DNA-binding transcription factor activity
ASTEX_RS10285	COG1690	Belongs to the RtcB family
ASTEX_RS10365	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ASTEX_RS10375	COG0166	Belongs to the GPI family
ASTEX_RS10395	COG0004	ammonium transporteR
ASTEX_RS10405	COG1012	belongs to the aldehyde dehydrogenase family
ASTEX_RS10425	COG1648	precorrin-2 dehydrogenase activity
ASTEX_RS10425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASTEX_RS10435	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ASTEX_RS10445	COG0175	sulfate reduction
ASTEX_RS10455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ASTEX_RS10480	COG0513	Belongs to the DEAD box helicase family
ASTEX_RS10490	COG0784	Response regulator, receiver
ASTEX_RS10490	COG2205	protein histidine kinase activity
ASTEX_RS10510	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ASTEX_RS10525	COG0395	ABC-type sugar transport system, permease component
ASTEX_RS10530	COG1175	transmembrane transport
ASTEX_RS10580	COG1028	Short-chain dehydrogenase reductase Sdr
ASTEX_RS10590	COG1028	Short-chain dehydrogenase reductase Sdr
ASTEX_RS10595	COG1414	Transcriptional regulator
ASTEX_RS10600	COG4948	Mandelate Racemase Muconate Lactonizing
ASTEX_RS10610	COG1028	Short-chain dehydrogenase reductase Sdr
ASTEX_RS10630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASTEX_RS10655	COG1028	Short-chain dehydrogenase reductase Sdr
ASTEX_RS10665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASTEX_RS10680	COG1083	cytidylyl-transferase
ASTEX_RS10685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ASTEX_RS10690	COG3550	peptidyl-serine autophosphorylation
ASTEX_RS10695	COG3620	sequence-specific DNA binding
ASTEX_RS10720	COG2755	lipolytic protein G-D-S-L family
ASTEX_RS10770	COG4952	isomerase
ASTEX_RS10790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ASTEX_RS10820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASTEX_RS10830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ASTEX_RS10885	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ASTEX_RS10890	COG3307	-O-antigen
ASTEX_RS10895	COG4372	Transposase
ASTEX_RS10900	COG3436	PFAM IS66 Orf2 family protein
ASTEX_RS10915	COG4372	Transposase
ASTEX_RS10950	COG0438	transferase activity, transferring glycosyl groups
ASTEX_RS10955	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ASTEX_RS10960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ASTEX_RS10995	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ASTEX_RS11055	COG3505	Type IV secretory pathway VirD4
ASTEX_RS11110	COG3311	Transcriptional regulator
ASTEX_RS11115	COG1569	PIN domain
ASTEX_RS11120	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ASTEX_RS11125	COG3932	Exopolysaccharide synthesis, ExoD
ASTEX_RS11130	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ASTEX_RS11160	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ASTEX_RS11165	COG1091	dTDP-4-dehydrorhamnose reductase activity
ASTEX_RS11170	COG1088	dTDP-glucose 4,6-dehydratase activity
ASTEX_RS11175	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ASTEX_RS11180	COG0339	signal peptide processing
ASTEX_RS11185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ASTEX_RS11255	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ASTEX_RS11275	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ASTEX_RS11280	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ASTEX_RS11290	COG0175	sulfate reduction
ASTEX_RS11295	COG1218	3'(2'),5'-bisphosphate nucleotidase
ASTEX_RS11300	COG2942	2-epimerase
ASTEX_RS11330	COG1435	thymidine kinase activity
ASTEX_RS11350	COG1396	sequence-specific DNA binding
ASTEX_RS11365	COG0288	reversible hydration of carbon dioxide
ASTEX_RS11385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ASTEX_RS11390	COG0545	Peptidyl-prolyl cis-trans isomerase
ASTEX_RS11395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ASTEX_RS11400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASTEX_RS11405	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ASTEX_RS11415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ASTEX_RS11425	COG2835	tetraacyldisaccharide 4'-kinase activity
ASTEX_RS11435	COG0477	Major facilitator Superfamily
ASTEX_RS11445	COG0745	RESPONSE REGULATOR receiver
ASTEX_RS11455	COG5002	protein histidine kinase activity
ASTEX_RS11460	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ASTEX_RS11485	COG3328	transposase activity
ASTEX_RS11490	COG2205	protein histidine kinase activity
ASTEX_RS11490	COG0784	Response regulator, receiver
ASTEX_RS11495	COG3300	MHYT domain
ASTEX_RS11495	COG5001	Diguanylate cyclase
ASTEX_RS11530	COG0492	ferredoxin-NADP+ reductase activity
ASTEX_RS11535	COG0583	DNA-binding transcription factor activity
ASTEX_RS11545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ASTEX_RS11610	COG0358	DNA primase activity
ASTEX_RS11615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ASTEX_RS11630	COG0285	dihydrofolate synthase activity
ASTEX_RS11645	COG0159	tryptophan synthase activity
ASTEX_RS11650	COG0133	tryptophan synthase activity
ASTEX_RS11655	COG0135	phosphoribosylanthranilate isomerase activity
ASTEX_RS11665	COG1970	mechanosensitive ion channel activity
ASTEX_RS11675	COG0539	negative regulation of cytoplasmic translation
ASTEX_RS11680	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ASTEX_RS11700	COG3668	Plasmid stabilization system
ASTEX_RS11720	COG0667	Aldo Keto reductase
ASTEX_RS11725	COG0412	Dienelactone hydrolase
ASTEX_RS11730	COG5006	permease, DMT superfamily
ASTEX_RS11735	COG2814	Major facilitator Superfamily
ASTEX_RS11740	COG0514	ATP-dependent DNA helicase (RecQ)
ASTEX_RS11745	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ASTEX_RS11760	COG0268	Binds directly to 16S ribosomal RNA
ASTEX_RS11860	COG0138	bifunctional purine biosynthesis protein purh
ASTEX_RS12170	COG1074	ATP-dependent DNA helicase activity
ASTEX_RS12470	COG0433	COG0433 Predicted ATPase
ASTEX_RS12525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASTEX_RS12650	COG1185	polyribonucleotide nucleotidyltransferase activity
ASTEX_RS12680	COG2133	pyrroloquinoline quinone binding
ASTEX_RS13035	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ASTEX_RS13105	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ASTEX_RS13865	COG2721	sulfolactate sulfo-lyase activity
ASTEX_RS13870	COG2721	sulfolactate sulfo-lyase activity
ASTEX_RS13895	COG2224	Isocitrate lyase
ASTEX_RS14150	COG0165	Argininosuccinate lyase
ASTEX_RS14240	COG1462	curli production assembly transport component CsgG
ASTEX_RS14685	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ASTEX_RS14765	COG0643	Histidine kinase
ASTEX_RS14765	COG2198	Histidine kinase
ASTEX_RS14855	COG3507	Belongs to the glycosyl hydrolase 43 family
ASTEX_RS14910	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASTEX_RS15220	COG0028	Belongs to the TPP enzyme family
ASTEX_RS15460	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ASTEX_RS15530	COG1073	alpha beta
ASTEX_RS16135	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ASTEX_RS16205	COG0366	Alpha amylase catalytic
ASTEX_RS16550	COG3540	Alkaline phosphatase
ASTEX_RS16565	COG4774	siderophore transport
ASTEX_RS16945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ASTEX_RS16970	COG0617	tRNA 3'-terminal CCA addition
ASTEX_RS18025	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ASTEX_RS18070	COG2902	Dehydrogenase
ASTEX_RS18595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASTEX_RS18630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ASTEX_RS18805	COG1074	ATP-dependent DNA helicase activity
ASTEX_RS18860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ASTEX_RS18995	COG0477	Major facilitator Superfamily
ASTEX_RS19065	COG0445	tRNA wobble uridine modification
ASTEX_RS19200	COG2201	protein-glutamate methylesterase activity
ASTEX_RS19230	COG3152	Membrane
ASTEX_RS19235	COG3152	Membrane
ASTEX_RS19305	COG0037	tRNA processing
ASTEX_RS19360	COG1216	Glycosyl transferase, family 2
ASTEX_RS19360	COG0463	Glycosyl transferase, family 2