locus-tag	class	description
EM6_RS00015	COG0450	alkyl hydroperoxide reductase
EM6_RS00055	COG0473	3-isopropylmalate dehydrogenase activity
EM6_RS00060	COG0066	3-isopropylmalate dehydratase activity
EM6_RS00065	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EM6_RS00075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EM6_RS00090	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EM6_RS00100	COG0129	dihydroxy-acid dehydratase activity
EM6_RS00130	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EM6_RS00135	COG3162	membrane
EM6_RS00190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EM6_RS00195	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EM6_RS00210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EM6_RS00260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EM6_RS00270	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EM6_RS00280	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EM6_RS00290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EM6_RS00310	COG0640	Transcriptional regulator
EM6_RS00330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EM6_RS00345	COG4067	protein conserved in archaea
EM6_RS00345	COG0189	ligase activity
EM6_RS00365	COG4974	Belongs to the 'phage' integrase family
EM6_RS00425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EM6_RS00435	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EM6_RS00450	COG3384	dioxygenase
EM6_RS00455	COG2353	YceI-like domain
EM6_RS00460	COG4771	TonB-dependent receptor
EM6_RS00465	COG0295	cytidine deaminase activity
EM6_RS00475	COG0469	pyruvate kinase activity
EM6_RS00495	COG1940	carbohydrate kinase activity
EM6_RS00500	COG2272	Belongs to the type-B carboxylesterase lipase family
EM6_RS00530	COG2308	Evidence 4 Homologs of previously reported genes of
EM6_RS00570	COG1959	2 iron, 2 sulfur cluster binding
EM6_RS00580	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
EM6_RS00605	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EM6_RS00615	COG3422	double-strand break repair
EM6_RS00625	COG2226	methyltransferase
EM6_RS00640	COG1410	methionine synthase
EM6_RS00640	COG0646	methionine synthase
EM6_RS00645	COG1181	Belongs to the D-alanine--D-alanine ligase family
EM6_RS00660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EM6_RS00675	COG0167	dihydroorotate dehydrogenase activity
EM6_RS00685	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EM6_RS00690	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
EM6_RS00695	COG4786	Flagellar basal body rod
EM6_RS00700	COG4786	Flagellar basal body rod
EM6_RS00710	COG1136	(ABC) transporter
EM6_RS00730	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EM6_RS00740	COG0783	Belongs to the Dps family
EM6_RS00760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EM6_RS00800	COG2885	chlorophyll binding
EM6_RS00805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EM6_RS00815	COG2957	Belongs to the agmatine deiminase family
EM6_RS00825	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EM6_RS00855	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EM6_RS00860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EM6_RS00875	COG1322	Protein conserved in bacteria
EM6_RS00890	COG0242	peptide deformylase activity
EM6_RS00900	COG0101	tRNA pseudouridine synthase activity
EM6_RS00940	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EM6_RS00940	COG2755	lipolytic protein G-D-S-L family
EM6_RS00950	COG0598	Magnesium transport protein CorA
EM6_RS00965	COG4206	TonB-dependent receptor
EM6_RS00985	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EM6_RS00990	COG5001	Diguanylate cyclase
EM6_RS01000	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EM6_RS01015	COG0588	phosphoglycerate mutase activity
EM6_RS01020	COG2852	Protein conserved in bacteria
EM6_RS01025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EM6_RS01025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EM6_RS01040	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EM6_RS01055	COG1294	oxidase, subunit
EM6_RS01065	COG1086	Polysaccharide biosynthesis protein
EM6_RS01075	COG0314	molybdopterin synthase activity
EM6_RS01080	COG0315	cyclic pyranopterin monophosphate synthase activity
EM6_RS01085	COG2264	protein methyltransferase activity
EM6_RS01095	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EM6_RS01120	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EM6_RS01140	COG0494	nUDIX hydrolase
EM6_RS01170	COG0706	membrane insertase activity
EM6_RS01205	COG0072	phenylalanine-tRNA ligase activity
EM6_RS01205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EM6_RS01225	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EM6_RS01265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EM6_RS01275	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EM6_RS01300	COG0351	phosphomethylpyrimidine kinase
EM6_RS01315	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EM6_RS01340	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EM6_RS01365	COG0564	pseudouridine synthase activity
EM6_RS01375	COG0848	biopolymer transport protein
EM6_RS01380	COG0302	gtp cyclohydrolase
EM6_RS01385	COG0215	cysteine-tRNA ligase activity
EM6_RS01415	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EM6_RS01430	COG0657	acetylesterase activity
EM6_RS01430	COG2755	lipolytic protein G-D-S-L family
EM6_RS01450	COG0210	DNA helicase
EM6_RS01515	COG1994	Peptidase M50
EM6_RS01540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EM6_RS01545	COG0174	glutamine synthetase
EM6_RS01555	COG3345	alpha-galactosidase
EM6_RS01565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EM6_RS01580	COG2079	MmgE PrpD family protein
EM6_RS01630	COG0861	Integral membrane protein TerC family
EM6_RS01635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EM6_RS01640	COG1692	metallophosphoesterase
EM6_RS01645	COG0217	transcriptional regulatory protein
EM6_RS01670	COG0768	penicillin binding
EM6_RS01675	COG0772	Belongs to the SEDS family
EM6_RS01690	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EM6_RS01695	COG0405	Gamma-glutamyltransferase
EM6_RS01720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EM6_RS01735	COG0405	Gamma-glutamyltransferase
EM6_RS01745	COG0438	transferase activity, transferring glycosyl groups
EM6_RS01750	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EM6_RS01760	COG0542	response to heat
EM6_RS01765	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EM6_RS01770	COG0142	geranyltranstransferase activity
EM6_RS01790	COG0322	excinuclease ABC activity
EM6_RS01815	COG3047	cAMP biosynthetic process
EM6_RS01820	COG1472	Belongs to the glycosyl hydrolase 3 family
EM6_RS01850	COG0483	inositol monophosphate 1-phosphatase activity
EM6_RS01855	COG1396	sequence-specific DNA binding
EM6_RS01860	COG0612	Peptidase, M16
EM6_RS01875	COG2264	protein methyltransferase activity
EM6_RS01885	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EM6_RS01940	COG0670	Belongs to the BI1 family
EM6_RS01945	COG2205	protein histidine kinase activity
EM6_RS01965	COG2239	Acts as a magnesium transporter
EM6_RS01975	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EM6_RS01980	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EM6_RS01990	COG0356	it plays a direct role in the translocation of protons across the membrane
EM6_RS02015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EM6_RS02025	COG1194	a g-specific adenine glycosylase
EM6_RS02040	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EM6_RS02045	COG3152	Membrane
EM6_RS02050	COG0354	folic acid binding
EM6_RS02060	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EM6_RS02070	COG1024	Enoyl-CoA hydratase
EM6_RS02085	COG0617	tRNA 3'-terminal CCA addition
EM6_RS02090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EM6_RS02090	COG0519	Catalyzes the synthesis of GMP from XMP
EM6_RS02100	COG0408	coproporphyrinogen oxidase activity
EM6_RS02105	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EM6_RS02110	COG0723	plastoquinol--plastocyanin reductase activity
EM6_RS02120	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EM6_RS02120	COG2857	Cytochrome c1
EM6_RS02125	COG1418	mRNA catabolic process
EM6_RS02135	COG0012	GTP binding
EM6_RS02145	COG1819	glycosyl
EM6_RS02150	COG0193	aminoacyl-tRNA hydrolase activity
EM6_RS02155	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EM6_RS02185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EM6_RS02225	COG1846	Transcriptional regulator
EM6_RS02230	COG1764	response to oxidative stress
EM6_RS02235	COG0667	Aldo Keto reductase
EM6_RS02245	COG0626	cystathionine gamma-synthase activity
EM6_RS02270	COG0460	homoserine dehydrogenase
EM6_RS02280	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EM6_RS02295	COG0393	Putative heavy-metal-binding
EM6_RS02325	COG5328	Belongs to the UPF0262 family
EM6_RS02335	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EM6_RS02340	COG0424	maF-like protein
EM6_RS02350	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EM6_RS02545	COG1196	nuclear chromosome segregation
EM6_RS02545	COG0739	heme binding
EM6_RS02545	COG0741	lytic transglycosylase activity
EM6_RS02585	COG0582	viral genome integration into host DNA
EM6_RS02595	COG0513	Belongs to the DEAD box helicase family
EM6_RS02655	COG0582	viral genome integration into host DNA
EM6_RS02660	COG5489	Protein of unknown function (DUF736)
EM6_RS02670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EM6_RS02675	COG2271	Major facilitator Superfamily
EM6_RS02685	COG0583	DNA-binding transcription factor activity
EM6_RS02690	COG4771	TonB-dependent receptor
EM6_RS02695	COG2971	BadF BadG BcrA BcrD
EM6_RS02700	COG3142	Participates in the control of copper homeostasis
EM6_RS02720	COG1472	Belongs to the glycosyl hydrolase 3 family
EM6_RS02735	COG3537	Alpha-1,2-mannosidase
EM6_RS02750	COG2188	Transcriptional regulator
EM6_RS02785	COG1862	Preprotein translocase
EM6_RS02805	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EM6_RS02820	COG3338	carbonate dehydratase activity
EM6_RS02825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EM6_RS02850	COG1706	bacterial-type flagellum-dependent cell motility
EM6_RS02895	COG0616	signal peptide processing
EM6_RS02900	COG1054	Belongs to the UPF0176 family
EM6_RS02930	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EM6_RS02935	COG0523	cobalamin synthesis protein
EM6_RS02945	COG3540	Alkaline phosphatase
EM6_RS02970	COG0640	Transcriptional regulator
EM6_RS02985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EM6_RS03000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EM6_RS03005	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EM6_RS03015	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EM6_RS03025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EM6_RS03030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EM6_RS03035	COG1522	sequence-specific DNA binding
EM6_RS03055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EM6_RS03060	COG1309	transcriptional regulator
EM6_RS03070	COG0673	inositol 2-dehydrogenase activity
EM6_RS03090	COG1217	gtp-binding protein TYPA
EM6_RS03110	COG4774	siderophore transport
EM6_RS03115	COG3128	pkhd-type hydroxylase
EM6_RS03135	COG1477	protein flavinylation
EM6_RS03150	COG3046	protein related to deoxyribodipyrimidine photolyase
EM6_RS03190	COG0657	acetylesterase activity
EM6_RS03190	COG2755	lipolytic protein G-D-S-L family
EM6_RS03215	COG3459	Glycosyltransferase 36 associated
EM6_RS03250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EM6_RS03275	COG1473	amidohydrolase
EM6_RS03280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EM6_RS03290	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
EM6_RS03310	COG3451	type IV secretory pathway VirB4
EM6_RS03325	COG0741	lytic transglycosylase activity
EM6_RS03340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EM6_RS03345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EM6_RS03370	COG2132	Multicopper oxidase
EM6_RS03385	COG1609	Transcriptional regulator
EM6_RS03390	COG0477	Major facilitator Superfamily
EM6_RS03400	COG2205	protein histidine kinase activity
EM6_RS03400	COG0784	Response regulator, receiver
EM6_RS03405	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EM6_RS03420	COG0805	protein transport
EM6_RS03430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EM6_RS03435	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EM6_RS03440	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EM6_RS03445	COG1472	Belongs to the glycosyl hydrolase 3 family
EM6_RS03465	COG1793	dna ligase
EM6_RS03470	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EM6_RS03470	COG1793	dna ligase
EM6_RS03475	COG1201	RNA secondary structure unwinding
EM6_RS03490	COG0583	DNA-binding transcription factor activity
EM6_RS03530	COG3867	Arabinogalactan endo-beta-1,4-galactanase
EM6_RS03550	COG3250	beta-galactosidase activity
EM6_RS03555	COG3250	beta-galactosidase activity
EM6_RS03570	COG1462	curli production assembly transport component CsgG
EM6_RS03575	COG1462	curli production assembly transport component CsgG
EM6_RS03590	COG0784	Response regulator, receiver
EM6_RS03590	COG2205	protein histidine kinase activity
EM6_RS03590	COG5002	protein histidine kinase activity
EM6_RS03595	COG2211	Major facilitator Superfamily
EM6_RS03625	COG1609	Transcriptional regulator
EM6_RS03630	COG4191	Histidine kinase
EM6_RS03630	COG0784	Response regulator, receiver
EM6_RS03655	COG0714	Associated with various cellular activities
EM6_RS03675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EM6_RS03710	COG0459	protein refolding
EM6_RS03730	COG0321	lipoyl(octanoyl) transferase activity
EM6_RS03735	COG3152	Membrane
EM6_RS03750	COG0564	pseudouridine synthase activity
EM6_RS03770	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EM6_RS03795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EM6_RS03800	COG1278	Cold shock
EM6_RS03810	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EM6_RS03830	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EM6_RS03840	COG0142	geranyltranstransferase activity
EM6_RS03855	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EM6_RS03870	COG1595	DNA-templated transcription, initiation
EM6_RS03885	COG1501	Belongs to the glycosyl hydrolase 31 family
EM6_RS03895	COG2186	Transcriptional regulator
EM6_RS03905	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EM6_RS03910	COG1684	flagellar biosynthetic protein fliR
EM6_RS03915	COG1987	bacterial-type flagellum assembly
EM6_RS03925	COG1677	Flagellar hook-basal body complex protein FliE
EM6_RS03930	COG1558	bacterial-type flagellum-dependent cell motility
EM6_RS03940	COG3190	flagellar
EM6_RS03945	COG1338	Plays a role in the flagellum-specific transport system
EM6_RS04005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EM6_RS04015	COG0842	Transport permease protein
EM6_RS04020	COG1131	(ABC) transporter
EM6_RS04030	COG1309	transcriptional regulator
EM6_RS04045	COG2267	carboxylic ester hydrolase activity
EM6_RS04050	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EM6_RS04060	COG0753	catalase activity
EM6_RS04070	COG2824	Alkylphosphonate utilization operon protein PhnA
EM6_RS04085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EM6_RS04100	COG0784	Response regulator, receiver
EM6_RS04100	COG2198	Histidine kinase
EM6_RS04100	COG2205	protein histidine kinase activity
EM6_RS04120	COG1566	PFAM secretion protein HlyD family protein
EM6_RS04130	COG1309	transcriptional regulator
EM6_RS04150	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
EM6_RS04170	COG1858	cytochrome C peroxidase
EM6_RS04195	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EM6_RS04205	COG2873	o-acetylhomoserine
EM6_RS04245	COG0582	viral genome integration into host DNA
EM6_RS04255	COG3507	Belongs to the glycosyl hydrolase 43 family
EM6_RS04280	COG0583	DNA-binding transcription factor activity
EM6_RS04310	COG0776	regulation of translation
EM6_RS04315	COG4957	zinc ion binding
EM6_RS04360	COG3507	Belongs to the glycosyl hydrolase 43 family
EM6_RS04375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EM6_RS04380	COG4948	Mandelate Racemase Muconate Lactonizing
EM6_RS04390	COG0823	Involved in the tonB-independent uptake of proteins
EM6_RS04390	COG1506	peptidase
EM6_RS04390	COG4946	Tricorn protease homolog
EM6_RS04420	COG2197	response regulator
EM6_RS04425	COG0840	transmembrane signaling receptor activity
EM6_RS04455	COG1278	Cold shock
EM6_RS04460	COG2813	Specifically methylates the guanine in position
EM6_RS04465	COG1187	pseudouridine synthase activity
EM6_RS04480	COG2205	protein histidine kinase activity
EM6_RS04505	COG0071	Belongs to the small heat shock protein (HSP20) family
EM6_RS04510	COG2378	regulation of single-species biofilm formation
EM6_RS04515	COG0626	cystathionine gamma-synthase activity
EM6_RS04520	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EM6_RS04530	COG4208	sulfate ABC transporter
EM6_RS04535	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EM6_RS04545	COG4206	TonB-dependent receptor
EM6_RS04550	COG0006	proline dipeptidase activity
EM6_RS04560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EM6_RS04565	COG0497	DNA recombination
EM6_RS04570	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EM6_RS04575	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EM6_RS04585	COG0849	cell division
EM6_RS04620	COG0387	Pfam Sodium calcium exchanger
EM6_RS04630	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EM6_RS04635	COG0640	Transcriptional regulator
EM6_RS04640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EM6_RS04705	COG1994	Peptidase M50
EM6_RS04710	COG1250	3-hydroxyacyl-CoA dehydrogenase
EM6_RS04710	COG1024	Enoyl-CoA hydratase
EM6_RS04715	COG0183	Belongs to the thiolase family
EM6_RS04725	COG3734	2-keto-3-deoxy-galactonokinase
EM6_RS04730	COG0800	Aldolase
EM6_RS04735	COG1733	regulation of RNA biosynthetic process
EM6_RS04740	COG0702	epimerase
EM6_RS04750	COG1051	belongs to the nudix hydrolase family
EM6_RS04775	COG1595	DNA-templated transcription, initiation
EM6_RS04795	COG1546	Belongs to the CinA family
EM6_RS04795	COG1058	Belongs to the CinA family
EM6_RS04800	COG1489	DNA binding
EM6_RS04805	COG0392	lysyltransferase activity
EM6_RS04805	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EM6_RS04815	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EM6_RS04870	COG0534	Mate efflux family protein
EM6_RS04875	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EM6_RS04890	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EM6_RS04900	COG0546	phosphoglycolate phosphatase activity
EM6_RS04925	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EM6_RS04955	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EM6_RS04980	COG0784	Response regulator, receiver
EM6_RS04980	COG2205	protein histidine kinase activity
EM6_RS04980	COG5002	protein histidine kinase activity
EM6_RS04990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EM6_RS04990	COG2022	thiamine diphosphate biosynthetic process
EM6_RS05020	COG0848	biopolymer transport protein
EM6_RS05030	COG2951	lytic endotransglycosylase activity
EM6_RS05055	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EM6_RS05105	COG3739	integral membrane protein
EM6_RS05130	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EM6_RS05130	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EM6_RS05140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EM6_RS05165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EM6_RS05170	COG0328	RNA-DNA hybrid ribonuclease activity
EM6_RS05190	COG1702	phosphate starvation-inducible protein PhoH
EM6_RS05215	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EM6_RS05225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EM6_RS05230	COG0745	RESPONSE REGULATOR receiver
EM6_RS05250	COG0037	tRNA processing
EM6_RS05265	COG2885	chlorophyll binding
EM6_RS05270	COG0823	Involved in the tonB-independent uptake of proteins
EM6_RS05295	COG0632	four-way junction helicase activity
EM6_RS05300	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EM6_RS05335	COG0488	(ABC) transporter
EM6_RS05340	COG3300	MHYT domain
EM6_RS05340	COG5001	Diguanylate cyclase
EM6_RS05345	COG2188	Transcriptional regulator
EM6_RS05360	COG2971	BadF BadG BcrA BcrD
EM6_RS05365	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EM6_RS05370	COG2885	chlorophyll binding
EM6_RS05395	COG0163	prenyltransferase activity
EM6_RS05440	COG0352	thiamine-phosphate diphosphorylase activity
EM6_RS05455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EM6_RS05460	COG0483	inositol monophosphate 1-phosphatase activity
EM6_RS05470	COG1309	transcriptional regulator
EM6_RS05480	COG1132	(ABC) transporter
EM6_RS05490	COG0387	Pfam Sodium calcium exchanger
EM6_RS05520	COG2171	N-acyltransferase activity
EM6_RS05530	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
EM6_RS05535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EM6_RS05540	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EM6_RS05545	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EM6_RS05560	COG0489	protein tyrosine kinase activity
EM6_RS05565	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EM6_RS05580	COG0129	dihydroxy-acid dehydratase activity
EM6_RS05595	COG1012	belongs to the aldehyde dehydrogenase family
EM6_RS05630	COG0318	PFAM AMP-dependent synthetase and ligase
EM6_RS05645	COG4771	TonB-dependent receptor
EM6_RS05655	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EM6_RS05680	COG1506	peptidase
EM6_RS05680	COG0823	Involved in the tonB-independent uptake of proteins
EM6_RS05695	COG1956	GAF domain-containing protein
EM6_RS05720	COG1238	metal cluster binding
EM6_RS05730	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
EM6_RS05745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EM6_RS05765	COG0203	ribosomal protein L17
EM6_RS05780	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EM6_RS05790	COG0563	adenylate kinase activity
EM6_RS05795	COG0201	protein transport
EM6_RS05800	COG0200	Binds to the 23S rRNA
EM6_RS05810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EM6_RS05815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EM6_RS05830	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EM6_RS05845	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EM6_RS05850	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EM6_RS05865	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EM6_RS05870	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EM6_RS05875	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EM6_RS05880	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EM6_RS05885	COG0089	rRNA binding
EM6_RS05895	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EM6_RS05900	COG0051	transcription antitermination factor activity, RNA binding
EM6_RS05915	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EM6_RS05930	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EM6_RS05950	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EM6_RS05955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EM6_RS06005	COG3023	N-Acetylmuramoyl-L-alanine amidase
EM6_RS06035	COG0006	proline dipeptidase activity
EM6_RS06055	COG1028	Short-chain dehydrogenase reductase Sdr
EM6_RS06065	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
EM6_RS06090	COG0463	Glycosyl transferase, family 2
EM6_RS06110	COG1132	(ABC) transporter
EM6_RS06130	COG0114	fumarate hydratase activity
EM6_RS06145	COG3842	ATPase activity
EM6_RS06150	COG1177	transmembrane transport
EM6_RS06155	COG1176	ABC-type spermidine putrescine transport system, permease component I
EM6_RS06165	COG0174	glutamine synthetase
EM6_RS06170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EM6_RS06175	COG1012	belongs to the aldehyde dehydrogenase family
EM6_RS06180	COG1012	belongs to the aldehyde dehydrogenase family
EM6_RS06190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EM6_RS06240	COG1522	sequence-specific DNA binding
EM6_RS06245	COG0686	Belongs to the AlaDH PNT family
EM6_RS06300	COG0443	Heat shock 70 kDa protein
EM6_RS06315	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EM6_RS06330	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EM6_RS06340	COG0107	imidazoleglycerol-phosphate synthase activity
EM6_RS06375	COG4948	Mandelate Racemase Muconate Lactonizing
EM6_RS06380	COG0385	Bile acid
EM6_RS06385	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EM6_RS06400	COG0442	prolyl-tRNA aminoacylation
EM6_RS06410	COG0625	glutathione transferase activity
EM6_RS06435	COG0738	Major facilitator superfamily
EM6_RS06445	COG1414	Transcriptional regulator
EM6_RS06460	COG2721	sulfolactate sulfo-lyase activity
EM6_RS06465	COG1028	Short-chain dehydrogenase reductase Sdr
EM6_RS06485	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EM6_RS06490	COG0732	type I restriction modification DNA specificity domain
EM6_RS06495	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EM6_RS06500	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EM6_RS06525	COG0477	Major facilitator Superfamily
EM6_RS06525	COG2814	Major facilitator Superfamily
EM6_RS06530	COG0129	dihydroxy-acid dehydratase activity
EM6_RS06535	COG3386	PFAM SMP-30 Gluconolaconase
EM6_RS06570	COG0505	Belongs to the CarA family
EM6_RS06575	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EM6_RS06585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EM6_RS06600	COG1505	serine-type exopeptidase activity
EM6_RS06610	COG1414	Transcriptional regulator
EM6_RS06615	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EM6_RS06625	COG3250	beta-galactosidase activity
EM6_RS06645	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EM6_RS06660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EM6_RS06670	COG1918	ferrous iron import across plasma membrane
EM6_RS06670	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EM6_RS06685	COG2252	PERMEase
EM6_RS06700	COG1472	Belongs to the glycosyl hydrolase 3 family
EM6_RS06705	COG1609	Transcriptional regulator
EM6_RS06710	COG0800	Aldolase
EM6_RS06715	COG0837	glucose binding
EM6_RS06725	COG0363	glucosamine-6-phosphate deaminase activity
EM6_RS06730	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EM6_RS06735	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EM6_RS06750	COG0308	aminopeptidase N
EM6_RS06760	COG2205	protein histidine kinase activity
EM6_RS06760	COG2202	Pas domain
EM6_RS06785	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EM6_RS06800	COG2205	protein histidine kinase activity
EM6_RS06815	COG1028	Short-chain dehydrogenase reductase Sdr
EM6_RS06825	COG5265	(ABC) transporter
EM6_RS06845	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EM6_RS06855	COG3657	addiction module killer protein
EM6_RS06860	COG2819	hydrolase of the alpha beta superfamily
EM6_RS06865	COG1082	Xylose isomerase domain protein TIM barrel
EM6_RS06870	COG1609	Transcriptional regulator
EM6_RS06880	COG1760	l-serine dehydratase
EM6_RS06920	COG1609	Transcriptional regulator
EM6_RS06950	COG5487	UPF0391 membrane protein
EM6_RS06960	COG1846	Transcriptional regulator
EM6_RS06990	COG5002	protein histidine kinase activity
EM6_RS07020	COG2186	Transcriptional regulator
EM6_RS07025	COG1301	dicarboxylic acid transport
EM6_RS07040	COG3655	Transcriptional regulator
EM6_RS07070	COG3088	subunit of a heme lyase
EM6_RS07075	COG1138	Cytochrome C-type biogenesis protein
EM6_RS07110	COG0484	heat shock protein binding
EM6_RS07185	COG4695	Portal protein
EM6_RS07205	COG2983	Belongs to the UPF0260 family
EM6_RS07210	COG0488	(ABC) transporter
EM6_RS07245	COG1522	sequence-specific DNA binding
EM6_RS07260	COG1024	Enoyl-CoA hydratase
EM6_RS07275	COG1960	acyl-CoA dehydrogenase activity
EM6_RS07280	COG0439	Biotin carboxylase
EM6_RS07285	COG1024	Enoyl-CoA hydratase
EM6_RS07290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EM6_RS07295	COG0583	DNA-binding transcription factor activity
EM6_RS07300	COG0028	Belongs to the TPP enzyme family
EM6_RS07305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EM6_RS07315	COG1960	acyl-CoA dehydrogenase activity
EM6_RS07320	COG1012	belongs to the aldehyde dehydrogenase family
EM6_RS07325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EM6_RS07365	COG1609	Transcriptional regulator
EM6_RS07425	COG1462	curli production assembly transport component CsgG
EM6_RS07435	COG0612	Peptidase, M16
EM6_RS07440	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EM6_RS07445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EM6_RS07485	COG0717	Belongs to the dCTP deaminase family
EM6_RS07490	COG2967	ApaG domain
EM6_RS07495	COG0840	transmembrane signaling receptor activity
EM6_RS07515	COG0019	diaminopimelate decarboxylase activity
EM6_RS07525	COG0165	Argininosuccinate lyase
EM6_RS07530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EM6_RS07535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EM6_RS07550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EM6_RS07550	COG2169	Transcriptional regulator
EM6_RS07555	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EM6_RS07555	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EM6_RS07560	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EM6_RS07565	COG2205	protein histidine kinase activity
EM6_RS07570	COG0745	RESPONSE REGULATOR receiver
EM6_RS07610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EM6_RS07610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EM6_RS07615	COG3549	Plasmid maintenance system killer
EM6_RS07625	COG2852	Protein conserved in bacteria
EM6_RS07640	COG1764	response to oxidative stress
EM6_RS07645	COG0121	glutamine amidotransferase
EM6_RS07665	COG1309	transcriptional regulator
EM6_RS07695	COG1250	3-hydroxyacyl-CoA dehydrogenase
EM6_RS07705	COG2311	Membrane
EM6_RS07710	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EM6_RS07710	COG1605	Chorismate mutase
EM6_RS07720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EM6_RS07725	COG1199	ATP-dependent helicase activity
EM6_RS07735	COG0730	response to heat
EM6_RS07775	COG2224	Isocitrate lyase
EM6_RS07785	COG1396	sequence-specific DNA binding
EM6_RS07785	COG3800	Transcriptional regulator
EM6_RS07795	COG2186	Transcriptional regulator
EM6_RS07810	COG0523	cobalamin synthesis protein
EM6_RS07815	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EM6_RS07830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EM6_RS07835	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EM6_RS07840	COG0799	negative regulation of ribosome biogenesis
EM6_RS07845	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EM6_RS07880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EM6_RS07885	COG2885	chlorophyll binding
EM6_RS07895	COG1086	Polysaccharide biosynthesis protein
EM6_RS07900	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EM6_RS07905	COG2089	acid synthase
EM6_RS07920	COG1073	alpha beta
EM6_RS07930	COG0303	'Molybdopterin
EM6_RS07935	COG0521	Mo-molybdopterin cofactor biosynthetic process
EM6_RS07940	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EM6_RS07945	COG2272	Belongs to the type-B carboxylesterase lipase family
EM6_RS07960	COG0246	Mannitol dehydrogenase
EM6_RS07965	COG2721	sulfolactate sulfo-lyase activity
EM6_RS07970	COG1609	Transcriptional regulator
EM6_RS07975	COG1904	glucuronate isomerase
EM6_RS07995	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EM6_RS08000	COG4133	protoheme IX ABC transporter activity
EM6_RS08005	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EM6_RS08010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EM6_RS08025	COG0077	Prephenate dehydratase
EM6_RS08025	COG1605	Chorismate mutase
EM6_RS08040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EM6_RS08060	COG0793	Belongs to the peptidase S41A family
EM6_RS08105	COG4964	Belongs to the GSP D family
EM6_RS08135	COG2176	DNA-directed DNA polymerase activity
EM6_RS08155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EM6_RS08160	COG0745	RESPONSE REGULATOR receiver
EM6_RS08170	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EM6_RS08200	COG0670	Belongs to the BI1 family
EM6_RS08220	COG3401	FG-GAP repeat protein
EM6_RS08225	COG2205	protein histidine kinase activity
EM6_RS08235	COG2124	cytochrome p450
EM6_RS08255	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EM6_RS08260	COG2856	Zn peptidase
EM6_RS08280	COG5507	3-demethylubiquinone-9 3-methyltransferase
EM6_RS08285	COG5507	3-demethylubiquinone-9 3-methyltransferase
EM6_RS08290	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EM6_RS08305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EM6_RS08315	COG1309	transcriptional regulator
EM6_RS08325	COG1899	peptidyl-lysine modification to peptidyl-hypusine
EM6_RS08340	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EM6_RS08345	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
EM6_RS08350	COG3639	organic phosphonate transmembrane transporter activity
EM6_RS08355	COG1028	Short-chain dehydrogenase reductase Sdr
EM6_RS08375	COG2917	probably involved in intracellular septation
EM6_RS08380	COG0552	protein localization to endoplasmic reticulum
EM6_RS08385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EM6_RS08400	COG0840	transmembrane signaling receptor activity
EM6_RS08405	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EM6_RS08410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EM6_RS08415	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EM6_RS08420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EM6_RS08430	COG1253	flavin adenine dinucleotide binding
EM6_RS08450	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EM6_RS08455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EM6_RS08475	COG0508	dehydrogenase complex catalyzes the overall conversion of
EM6_RS08485	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EM6_RS08490	COG0045	succinate-CoA ligase (ADP-forming) activity
EM6_RS08495	COG2814	Major facilitator Superfamily
EM6_RS08555	COG1999	signal sequence binding
EM6_RS08565	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
EM6_RS08580	COG0640	Transcriptional regulator
EM6_RS08590	COG2205	protein histidine kinase activity
EM6_RS08600	COG0745	RESPONSE REGULATOR receiver
EM6_RS08625	COG0477	Major facilitator Superfamily
EM6_RS08645	COG1137	ATPase activity
EM6_RS08650	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EM6_RS08655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EM6_RS08660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EM6_RS08665	COG0427	acetyl-CoA hydrolase
EM6_RS08670	COG0071	Belongs to the small heat shock protein (HSP20) family
EM6_RS08680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EM6_RS08685	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EM6_RS08690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EM6_RS08695	COG0352	thiamine-phosphate diphosphorylase activity
EM6_RS08710	COG2239	Acts as a magnesium transporter
EM6_RS08715	COG0633	Ferredoxin
EM6_RS08720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EM6_RS08725	COG1053	succinate dehydrogenase
EM6_RS08735	COG2009	succinate dehydrogenase
EM6_RS08760	COG0436	Aminotransferase
EM6_RS08775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EM6_RS08785	COG0251	oxidation-reduction process
EM6_RS08790	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EM6_RS08795	COG4953	penicillin-binding protein 1C
EM6_RS08800	COG2373	Large extracellular alpha-helical protein
EM6_RS08805	COG0745	RESPONSE REGULATOR receiver
EM6_RS08825	COG0495	leucyl-tRNA aminoacylation
EM6_RS08865	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EM6_RS08875	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EM6_RS08880	COG1981	membrane
EM6_RS08885	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EM6_RS08895	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EM6_RS08900	COG0424	maF-like protein
EM6_RS08910	COG0237	dephospho-CoA kinase activity
EM6_RS08915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EM6_RS08920	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EM6_RS08930	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EM6_RS08940	COG0433	COG0433 Predicted ATPase
EM6_RS08955	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EM6_RS08980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EM6_RS08985	COG1702	phosphate starvation-inducible protein PhoH
EM6_RS08995	COG1253	flavin adenine dinucleotide binding
EM6_RS09000	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EM6_RS09005	COG1396	sequence-specific DNA binding
EM6_RS09010	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EM6_RS09025	COG0779	Required for maturation of 30S ribosomal subunits
EM6_RS09040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EM6_RS09040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EM6_RS09065	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EM6_RS09075	COG1185	polyribonucleotide nucleotidyltransferase activity
EM6_RS09100	COG2133	pyrroloquinoline quinone binding
EM6_RS09105	COG0335	large ribosomal subunit rRNA binding
EM6_RS09110	COG0336	Belongs to the RNA methyltransferase TrmD family
EM6_RS09115	COG4771	TonB-dependent receptor
EM6_RS09120	COG1695	Transcriptional regulator
EM6_RS09145	COG1846	Transcriptional regulator
EM6_RS09145	COG1940	carbohydrate kinase activity
EM6_RS09150	COG3250	beta-galactosidase activity
EM6_RS09160	COG0840	transmembrane signaling receptor activity
EM6_RS09170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EM6_RS09175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EM6_RS09180	COG1674	ftsk spoiiie
EM6_RS09185	COG3047	cAMP biosynthetic process
EM6_RS09195	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EM6_RS09200	COG1597	lipid kinase activity
EM6_RS09210	COG1074	ATP-dependent DNA helicase activity
EM6_RS09220	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EM6_RS09225	COG3178	'Phosphotransferase
EM6_RS09230	COG0802	atpase or kinase
EM6_RS09260	COG2226	methyltransferase
EM6_RS09265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EM6_RS09270	COG0840	transmembrane signaling receptor activity
EM6_RS09275	COG0598	Magnesium transport protein CorA
EM6_RS09280	COG5001	Diguanylate cyclase
EM6_RS09290	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EM6_RS09295	COG0756	dUTP diphosphatase activity
EM6_RS09305	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EM6_RS09310	COG0484	heat shock protein binding
EM6_RS09315	COG0443	Heat shock 70 kDa protein
EM6_RS09320	COG0412	Dienelactone hydrolase
EM6_RS09345	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EM6_RS09350	COG3655	Transcriptional regulator
EM6_RS09360	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EM6_RS09365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EM6_RS09375	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EM6_RS09385	COG0189	ligase activity
EM6_RS09390	COG0606	chelatase, subunit chli
EM6_RS09395	COG0784	Response regulator, receiver
EM6_RS09395	COG2205	protein histidine kinase activity
EM6_RS09395	COG5002	protein histidine kinase activity
EM6_RS09400	COG2807	transmembrane transport
EM6_RS09405	COG0280	phosphate acetyltransferase
EM6_RS09405	COG0281	malic enzyme
EM6_RS09410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EM6_RS09415	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EM6_RS09430	COG0728	peptidoglycan biosynthetic process
EM6_RS09435	COG0180	Tryptophanyl-tRNA synthetase
EM6_RS09455	COG0138	bifunctional purine biosynthesis protein purh
EM6_RS09470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EM6_RS09475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EM6_RS09475	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EM6_RS09480	COG0501	Belongs to the peptidase M48B family
EM6_RS09495	COG0284	orotidine-5'-phosphate decarboxylase activity
EM6_RS09500	COG2095	MarC family integral membrane protein
EM6_RS09505	COG4221	oxidoreductase activity
EM6_RS09510	COG1959	2 iron, 2 sulfur cluster binding
EM6_RS09530	COG0494	nUDIX hydrolase
EM6_RS09565	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EM6_RS09570	COG0268	Binds directly to 16S ribosomal RNA
EM6_RS09585	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EM6_RS09590	COG0514	ATP-dependent DNA helicase (RecQ)
EM6_RS09595	COG2814	Major facilitator Superfamily
EM6_RS09600	COG5006	permease, DMT superfamily
EM6_RS09640	COG0539	negative regulation of cytoplasmic translation
EM6_RS09650	COG1970	mechanosensitive ion channel activity
EM6_RS09660	COG0135	phosphoribosylanthranilate isomerase activity
EM6_RS09665	COG0133	tryptophan synthase activity
EM6_RS09670	COG0159	tryptophan synthase activity
EM6_RS09685	COG0285	dihydrofolate synthase activity
EM6_RS09690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EM6_RS09710	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EM6_RS09720	COG0583	DNA-binding transcription factor activity
EM6_RS09725	COG0492	ferredoxin-NADP+ reductase activity
EM6_RS09755	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EM6_RS09760	COG5002	protein histidine kinase activity
EM6_RS09770	COG0745	RESPONSE REGULATOR receiver
EM6_RS09780	COG0477	Major facilitator Superfamily
EM6_RS09785	COG3118	belongs to the thioredoxin family
EM6_RS09790	COG2835	tetraacyldisaccharide 4'-kinase activity
EM6_RS09800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EM6_RS09810	COG0545	Peptidyl-prolyl cis-trans isomerase
EM6_RS09815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EM6_RS09835	COG0288	reversible hydration of carbon dioxide
EM6_RS09845	COG1051	belongs to the nudix hydrolase family
EM6_RS09845	COG1056	cytidyltransferase-related domain
EM6_RS09850	COG1435	thymidine kinase activity
EM6_RS09870	COG2942	2-epimerase
EM6_RS09880	COG0175	sulfate reduction
EM6_RS09890	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EM6_RS09895	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EM6_RS09900	COG0517	IMP dehydrogenase activity
EM6_RS09900	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EM6_RS09945	COG1216	Glycosyl transferase, family 2
EM6_RS09945	COG0438	transferase activity, transferring glycosyl groups
EM6_RS10025	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
EM6_RS10030	COG1088	dTDP-glucose 4,6-dehydratase activity
EM6_RS10035	COG1091	dTDP-4-dehydrorhamnose reductase activity
EM6_RS10040	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EM6_RS10055	COG3754	Rhamnan synthesis protein F
EM6_RS10060	COG0463	Glycosyl transferase, family 2
EM6_RS10065	COG3754	Rhamnan synthesis protein F
EM6_RS10105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EM6_RS10110	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
EM6_RS10115	COG0438	transferase activity, transferring glycosyl groups
EM6_RS10115	COG1216	Glycosyl transferase, family 2
EM6_RS10120	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EM6_RS10125	COG0339	signal peptide processing
EM6_RS10150	COG3932	Exopolysaccharide synthesis, ExoD
EM6_RS10155	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EM6_RS10185	COG4952	isomerase
EM6_RS10210	COG2755	lipolytic protein G-D-S-L family
EM6_RS10230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EM6_RS10235	COG1083	cytidylyl-transferase
EM6_RS10250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EM6_RS10260	COG1028	Short-chain dehydrogenase reductase Sdr
EM6_RS10280	COG1028	Short-chain dehydrogenase reductase Sdr
EM6_RS10290	COG4948	Mandelate Racemase Muconate Lactonizing
EM6_RS10295	COG1414	Transcriptional regulator
EM6_RS10300	COG1028	Short-chain dehydrogenase reductase Sdr
EM6_RS10310	COG1028	Short-chain dehydrogenase reductase Sdr
EM6_RS10325	COG1175	transmembrane transport
EM6_RS10330	COG0395	ABC-type sugar transport system, permease component
EM6_RS10345	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EM6_RS10375	COG0513	Belongs to the DEAD box helicase family
EM6_RS10390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EM6_RS10400	COG0175	sulfate reduction
EM6_RS10410	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EM6_RS10420	COG1648	precorrin-2 dehydrogenase activity
EM6_RS10420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EM6_RS10445	COG1012	belongs to the aldehyde dehydrogenase family
EM6_RS10460	COG0004	ammonium transporteR
EM6_RS10480	COG0166	Belongs to the GPI family
EM6_RS10490	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EM6_RS10545	COG0438	transferase activity, transferring glycosyl groups
EM6_RS10550	COG1522	sequence-specific DNA binding
EM6_RS10570	COG0482	sulfurtransferase activity
EM6_RS10595	COG1749	Flagellar hook protein flgE
EM6_RS10605	COG1766	The M ring may be actively involved in energy transduction
EM6_RS10610	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EM6_RS10620	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EM6_RS10625	COG2204	response regulator
EM6_RS10635	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EM6_RS10650	COG2382	esterase
EM6_RS10650	COG3693	PFAM glycoside hydrolase, family 10
EM6_RS10650	COG3507	Belongs to the glycosyl hydrolase 43 family
EM6_RS10675	COG3609	addiction module antidote protein, CC2985 family
EM6_RS10720	COG2201	protein-glutamate methylesterase activity
EM6_RS10725	COG0643	Histidine kinase
EM6_RS10725	COG0784	Response regulator, receiver
EM6_RS10725	COG2198	Histidine kinase
EM6_RS10735	COG0784	Response regulator, receiver
EM6_RS10735	COG0643	Histidine kinase
EM6_RS10735	COG2198	Histidine kinase
EM6_RS10760	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EM6_RS10775	COG2166	iron-sulfur cluster assembly
EM6_RS10780	COG2202	Pas domain
EM6_RS10780	COG2205	protein histidine kinase activity
EM6_RS10785	COG2205	protein histidine kinase activity
EM6_RS10805	COG1272	protein, Hemolysin III
EM6_RS10815	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EM6_RS10850	COG0746	molybdenum cofactor guanylyltransferase activity
EM6_RS10875	COG0745	RESPONSE REGULATOR receiver
EM6_RS10880	COG2205	protein histidine kinase activity
EM6_RS10885	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EM6_RS10890	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EM6_RS10895	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EM6_RS10915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EM6_RS10920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EM6_RS10935	COG1116	anion transmembrane transporter activity
EM6_RS10940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EM6_RS10945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EM6_RS10960	COG4771	TonB-dependent receptor
EM6_RS10970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EM6_RS10975	COG3577	Aspartyl protease
EM6_RS10990	COG0840	transmembrane signaling receptor activity
EM6_RS11000	COG0556	nucleotide-excision repair
EM6_RS11025	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EM6_RS11035	COG0492	ferredoxin-NADP+ reductase activity
EM6_RS11065	COG2154	pterin-4-alpha-carbinolamine dehydratase
EM6_RS11070	COG3186	Phenylalanine-4-hydroxylase
EM6_RS11090	COG2205	protein histidine kinase activity
EM6_RS11100	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EM6_RS11105	COG0784	Response regulator, receiver
EM6_RS11105	COG2198	Histidine kinase
EM6_RS11105	COG2205	protein histidine kinase activity
EM6_RS11125	COG0590	tRNA wobble adenosine to inosine editing
EM6_RS11135	COG0668	transmembrane transport
EM6_RS11165	COG4974	Belongs to the 'phage' integrase family
EM6_RS11175	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EM6_RS11190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EM6_RS11195	COG1309	transcriptional regulator
EM6_RS11200	COG2321	neutral zinc metallopeptidase
EM6_RS11235	COG2010	Cytochrome c
EM6_RS11270	COG0657	acetylesterase activity
EM6_RS11275	COG1309	transcriptional regulator
EM6_RS11280	COG2945	thiolester hydrolase activity
EM6_RS11280	COG0596	Alpha beta hydrolase
EM6_RS11285	COG4771	TonB-dependent receptor
EM6_RS11295	COG1028	Short-chain dehydrogenase reductase Sdr
EM6_RS11320	COG4677	pectinesterase activity
EM6_RS11335	COG2271	Major facilitator Superfamily
EM6_RS11340	COG0577	efflux transmembrane transporter activity
EM6_RS11345	COG1136	(ABC) transporter
EM6_RS11355	COG2204	response regulator
EM6_RS11360	COG3852	Histidine kinase
EM6_RS11370	COG1301	dicarboxylic acid transport
EM6_RS11375	COG4191	Histidine kinase
EM6_RS11380	COG2204	response regulator
EM6_RS11385	COG3250	beta-galactosidase activity
EM6_RS11395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EM6_RS11400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EM6_RS11425	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EM6_RS11435	COG5001	Diguanylate cyclase
EM6_RS11435	COG3300	MHYT domain
EM6_RS11450	COG4957	zinc ion binding
EM6_RS11500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EM6_RS11505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EM6_RS11515	COG0840	transmembrane signaling receptor activity
EM6_RS11520	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EM6_RS11525	COG0573	inorganic phosphate transmembrane transporter activity
EM6_RS11530	COG0581	inorganic phosphate transmembrane transporter activity
EM6_RS11535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EM6_RS11545	COG3609	addiction module antidote protein, CC2985 family
EM6_RS11550	COG1304	FMN binding
EM6_RS11555	COG1028	Short-chain dehydrogenase reductase Sdr
EM6_RS11560	COG1609	Transcriptional regulator
EM6_RS11575	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EM6_RS11600	COG2866	Carboxypeptidase
EM6_RS11630	COG4771	TonB-dependent receptor
EM6_RS11640	COG1609	Transcriptional regulator
EM6_RS11650	COG2211	Major facilitator Superfamily
EM6_RS11665	COG1278	Cold shock
EM6_RS11685	COG3661	Belongs to the glycosyl hydrolase 67 family
EM6_RS11690	COG4948	Mandelate Racemase Muconate Lactonizing
EM6_RS11710	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EM6_RS11715	COG2011	ABC-type metal ion transport system permease component
EM6_RS11735	COG0475	glutathione-regulated potassium exporter activity
EM6_RS11745	COG0745	RESPONSE REGULATOR receiver
EM6_RS11765	COG4251	negative regulation of phosphorylation
EM6_RS11770	COG0784	Response regulator, receiver
EM6_RS11825	COG4206	TonB-dependent receptor
EM6_RS11835	COG0531	amino acid
EM6_RS11850	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EM6_RS11855	COG3254	rhamnose metabolic process
EM6_RS11860	COG1448	Aminotransferase
EM6_RS11875	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EM6_RS11890	COG2271	Major facilitator Superfamily
EM6_RS11900	COG2205	protein histidine kinase activity
EM6_RS11900	COG0784	Response regulator, receiver
EM6_RS11945	COG0714	Associated with various cellular activities
EM6_RS11970	COG5002	protein histidine kinase activity
EM6_RS11970	COG5001	Diguanylate cyclase
EM6_RS11975	COG1309	transcriptional regulator
EM6_RS11980	COG3300	MHYT domain
EM6_RS11980	COG5001	Diguanylate cyclase
EM6_RS11985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EM6_RS11990	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EM6_RS12000	COG2884	Cell division ATP-binding protein ftsE
EM6_RS12015	COG0204	Acyl-transferase
EM6_RS12035	COG0653	protein targeting
EM6_RS12040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EM6_RS12045	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EM6_RS12065	COG0494	nUDIX hydrolase
EM6_RS12075	COG2226	methyltransferase
EM6_RS12090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EM6_RS12105	COG4232	protein-disulfide reductase activity
EM6_RS12120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EM6_RS12135	COG3738	Protein conserved in bacteria
EM6_RS12145	COG0431	NADPH-dependent FMN reductase
EM6_RS12155	COG1573	uracil-dna glycosylase
EM6_RS12165	COG1187	pseudouridine synthase activity
EM6_RS12170	COG0519	Catalyzes the synthesis of GMP from XMP
EM6_RS12180	COG4771	TonB-dependent receptor
EM6_RS12190	COG1595	DNA-templated transcription, initiation
EM6_RS12195	COG0438	transferase activity, transferring glycosyl groups
EM6_RS12215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EM6_RS12220	COG0484	heat shock protein binding
EM6_RS12265	COG0196	riboflavin kinase activity
EM6_RS12275	COG0745	RESPONSE REGULATOR receiver
EM6_RS12310	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EM6_RS12315	COG2201	protein-glutamate methylesterase activity
EM6_RS12345	COG1754	DNA topoisomerase type I activity
EM6_RS12345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EM6_RS12365	COG0758	DNA mediated transformation
EM6_RS12365	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EM6_RS12375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EM6_RS12380	COG0540	Belongs to the ATCase OTCase family
EM6_RS12385	COG1064	alcohol dehydrogenase
EM6_RS12395	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EM6_RS12410	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EM6_RS12415	COG0154	amidase activity
EM6_RS12435	COG3152	Membrane
EM6_RS12445	COG0582	viral genome integration into host DNA
EM6_RS12530	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EM6_RS12535	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EM6_RS12535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EM6_RS12550	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EM6_RS12550	COG4124	Belongs to the glycosyl hydrolase 26 family
EM6_RS12575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EM6_RS12585	COG2119	membrane
EM6_RS12605	COG2755	lipolytic protein G-D-S-L family
EM6_RS12610	COG0538	isocitrate dehydrogenase activity
EM6_RS12620	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EM6_RS12670	COG3387	PFAM Glycoside hydrolase 15-related
EM6_RS12675	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EM6_RS12680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EM6_RS12690	COG0583	DNA-binding transcription factor activity
EM6_RS12710	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EM6_RS12730	COG2072	flavoprotein involved in K transport
EM6_RS12735	COG2351	hydroxyisourate hydrolase activity
EM6_RS12745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EM6_RS12755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EM6_RS12760	COG0402	S-adenosylhomocysteine deaminase activity
EM6_RS12775	COG0316	Belongs to the HesB IscA family
EM6_RS12785	COG0346	lactoylglutathione lyase activity
EM6_RS12800	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EM6_RS12810	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EM6_RS12815	COG1607	acyl-coa hydrolase
EM6_RS12850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EM6_RS12870	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EM6_RS12880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EM6_RS12880	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EM6_RS12935	COG0673	inositol 2-dehydrogenase activity
EM6_RS12970	COG2755	lipolytic protein G-D-S-L family
EM6_RS12985	COG3250	beta-galactosidase activity
EM6_RS12995	COG2223	nitrite transmembrane transporter activity
EM6_RS13000	COG2201	protein-glutamate methylesterase activity
EM6_RS13010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EM6_RS13020	COG0243	molybdopterin cofactor binding
EM6_RS13025	COG1116	anion transmembrane transporter activity
EM6_RS13030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EM6_RS13035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EM6_RS13055	COG0577	efflux transmembrane transporter activity
EM6_RS13055	COG1136	(ABC) transporter
EM6_RS13085	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EM6_RS13090	COG3250	beta-galactosidase activity
EM6_RS13095	COG1741	Belongs to the pirin family
EM6_RS13120	COG0657	acetylesterase activity
EM6_RS13135	COG3104	oligopeptide transport
EM6_RS13145	COG0312	modulator of DNA gyrase
EM6_RS13155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EM6_RS13160	COG0109	protoheme IX farnesyltransferase activity
EM6_RS13165	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EM6_RS13180	COG3346	SURF1 family
EM6_RS13185	COG0612	Peptidase, M16
EM6_RS13190	COG0584	glycerophosphoryl diester phosphodiesterase
EM6_RS13195	COG1678	Uncharacterized ACR, COG1678
EM6_RS13205	COG1960	acyl-CoA dehydrogenase activity
EM6_RS13245	COG0602	queuosine metabolic process
EM6_RS13250	COG0248	Ppx GppA phosphatase
EM6_RS13270	COG0343	queuine tRNA-ribosyltransferase activity
EM6_RS13285	COG0436	Aminotransferase
EM6_RS13290	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EM6_RS13305	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EM6_RS13350	COG0582	viral genome integration into host DNA
EM6_RS13405	COG1393	Belongs to the ArsC family
EM6_RS13415	COG1595	DNA-templated transcription, initiation
EM6_RS13425	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EM6_RS13440	COG1160	GTP binding
EM6_RS13465	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EM6_RS13480	COG0305	Participates in initiation and elongation during chromosome replication
EM6_RS13515	COG2226	methyltransferase
EM6_RS13520	COG1301	dicarboxylic acid transport
EM6_RS13545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EM6_RS13565	COG0501	Belongs to the peptidase M48B family
EM6_RS13570	COG1530	ribonuclease E activity
EM6_RS13580	COG3474	cytochrome
EM6_RS13635	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EM6_RS13640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EM6_RS13645	COG0649	NAD binding
EM6_RS13660	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EM6_RS13665	COG2314	TM2 domain
EM6_RS13675	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EM6_RS13680	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EM6_RS13705	COG1007	ATP synthesis coupled electron transport
EM6_RS13715	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EM6_RS13725	COG3243	poly(R)-hydroxyalkanoic acid synthase
EM6_RS13735	COG1494	fructose-1,6-bisphosphatase
EM6_RS13740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EM6_RS13740	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EM6_RS13755	COG1278	Cold shock
EM6_RS13775	COG3034	peptidoglycan biosynthetic process
EM6_RS13805	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EM6_RS13810	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EM6_RS13840	COG1136	(ABC) transporter
EM6_RS13850	COG0052	Belongs to the universal ribosomal protein uS2 family
EM6_RS13860	COG0528	UMP kinase activity
EM6_RS13865	COG0233	cytoplasmic translational termination
EM6_RS13870	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EM6_RS13875	COG4589	Belongs to the CDS family
EM6_RS13885	COG0750	zinc metalloprotease
EM6_RS13890	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EM6_RS13900	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EM6_RS13905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EM6_RS13915	COG3494	Protein of unknown function (DUF1009)
EM6_RS13920	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EM6_RS13925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EM6_RS13930	COG0372	Belongs to the citrate synthase family
EM6_RS13935	COG2333	competence protein COMEC
EM6_RS13935	COG0658	competence protein
EM6_RS13945	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EM6_RS13950	COG0134	indole-3-glycerol-phosphate synthase activity
EM6_RS13970	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EM6_RS13980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EM6_RS13985	COG2204	response regulator
EM6_RS13990	COG5000	phosphorelay sensor kinase activity
EM6_RS14005	COG0321	lipoyl(octanoyl) transferase activity
EM6_RS14005	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EM6_RS14010	COG0084	hydrolase, TatD family'
EM6_RS14015	COG0470	DNA polymerase III
EM6_RS14020	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EM6_RS14070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EM6_RS14075	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EM6_RS14080	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EM6_RS14095	COG0463	Glycosyl transferase, family 2
EM6_RS14100	COG0415	Belongs to the DNA photolyase family
EM6_RS14105	COG2897	thiosulfate sulfurtransferase activity
EM6_RS14110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EM6_RS14125	COG0251	oxidation-reduction process
EM6_RS14130	COG0504	CTP synthase activity
EM6_RS14140	COG0149	triose-phosphate isomerase activity
EM6_RS14150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EM6_RS14160	COG4651	solute:proton antiporter activity
EM6_RS14160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EM6_RS14170	COG3956	TIGRFAM MazG family protein
EM6_RS14175	COG0823	Involved in the tonB-independent uptake of proteins
EM6_RS14190	COG1121	(ABC) transporter
EM6_RS14195	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EM6_RS14200	COG1546	Belongs to the CinA family
EM6_RS14200	COG1058	Belongs to the CinA family
EM6_RS14220	COG0318	PFAM AMP-dependent synthetase and ligase
EM6_RS14220	COG0204	Acyl-transferase
EM6_RS14240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EM6_RS14245	COG0508	dehydrogenase complex catalyzes the overall conversion of
EM6_RS14250	COG0508	dehydrogenase complex catalyzes the overall conversion of
EM6_RS14250	COG0022	dehydrogenase e1 component
EM6_RS14255	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EM6_RS14260	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EM6_RS14265	COG0148	phosphopyruvate hydratase activity
EM6_RS14270	COG0546	phosphoglycolate phosphatase activity
EM6_RS14300	COG0776	regulation of translation
EM6_RS14305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EM6_RS14310	COG0416	fatty acid biosynthetic process
EM6_RS14330	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EM6_RS14340	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EM6_RS14350	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EM6_RS14355	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EM6_RS14355	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EM6_RS14370	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EM6_RS14375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EM6_RS14395	COG0156	8-amino-7-oxononanoate synthase activity
EM6_RS14405	COG0113	porphobilinogen synthase activity
EM6_RS14415	COG2084	Dehydrogenase
EM6_RS14420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EM6_RS14425	COG1360	Flagellar Motor Protein
EM6_RS14430	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EM6_RS14435	COG3932	Exopolysaccharide synthesis, ExoD
EM6_RS14440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EM6_RS14455	COG1381	Involved in DNA repair and RecF pathway recombination
EM6_RS14475	COG0736	holo-[acyl-carrier-protein] synthase activity
EM6_RS14480	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EM6_RS14510	COG1758	RNA polymerase activity
EM6_RS14520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EM6_RS14535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EM6_RS14540	COG0741	lytic transglycosylase activity
EM6_RS14545	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EM6_RS14565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EM6_RS14565	COG0116	Belongs to the methyltransferase superfamily
EM6_RS14570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EM6_RS14580	COG1643	Atp-dependent helicase
EM6_RS14585	COG0531	amino acid
EM6_RS14590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EM6_RS14600	COG2081	HI0933 family
EM6_RS14605	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EM6_RS14610	COG0085	RNA polymerase activity
EM6_RS14645	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EM6_RS14650	COG0194	GDP metabolic process
EM6_RS14655	COG1561	YicC-like family, N-terminal region
EM6_RS14660	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EM6_RS14665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EM6_RS14670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EM6_RS14680	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EM6_RS14685	COG1073	alpha beta
EM6_RS14690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EM6_RS14695	COG0360	Binds together with S18 to 16S ribosomal RNA
EM6_RS14705	COG0359	binds to the 23S rRNA
EM6_RS14715	COG0347	Belongs to the P(II) protein family
EM6_RS14720	COG0174	glutamine synthetase
EM6_RS14725	COG0004	ammonium transporteR
EM6_RS14740	COG0187	DNA topoisomerase II activity
EM6_RS14745	COG0513	Belongs to the DEAD box helicase family
EM6_RS14750	COG3706	GGDEF domain
EM6_RS14770	COG0316	Belongs to the HesB IscA family
EM6_RS14775	COG2151	metal-sulfur cluster biosynthetic enzyme
EM6_RS14780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EM6_RS14785	COG0719	Fe-S assembly protein
EM6_RS14790	COG0396	ATPase activity
EM6_RS14800	COG0719	Fe-S assembly protein
EM6_RS14805	COG1104	cysteine desulfurase activity
EM6_RS14810	COG1959	2 iron, 2 sulfur cluster binding
EM6_RS14815	COG2945	thiolester hydrolase activity
EM6_RS14820	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EM6_RS14835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EM6_RS14840	COG0739	heme binding
EM6_RS14855	COG0222	ribosome binding
EM6_RS14865	COG4977	sequence-specific DNA binding
EM6_RS14880	COG3609	addiction module antidote protein, CC2985 family
EM6_RS14885	COG0081	regulation of translation
EM6_RS14890	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EM6_RS14900	COG0250	Participates in transcription elongation, termination and antitermination
EM6_RS14905	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EM6_RS14930	COG2832	Protein of unknown function (DUF454)
EM6_RS14935	COG3152	Membrane
EM6_RS14940	COG0412	Dienelactone hydrolase
EM6_RS14945	COG0861	Integral membrane protein TerC family
EM6_RS14950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EM6_RS14965	COG3152	Membrane
EM6_RS14980	COG1487	ribonuclease activity
EM6_RS15010	COG0511	ligase activity, forming carbon-carbon bonds
EM6_RS15015	COG0439	Biotin carboxylase
EM6_RS15040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EM6_RS15055	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EM6_RS15075	COG0248	Ppx GppA phosphatase
EM6_RS15085	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EM6_RS15090	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EM6_RS15095	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EM6_RS15100	COG0105	UTP biosynthetic process
EM6_RS15105	COG0488	(ABC) transporter
EM6_RS15120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EM6_RS15140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EM6_RS15145	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EM6_RS15150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EM6_RS15160	COG0235	Class ii aldolase
EM6_RS15170	COG0330	HflC and HflK could
EM6_RS15180	COG0277	FAD linked oxidase domain protein
EM6_RS15185	COG0745	RESPONSE REGULATOR receiver
EM6_RS15190	COG3022	response to hydroperoxide
EM6_RS15195	COG0009	L-threonylcarbamoyladenylate synthase
EM6_RS15200	COG3038	cytochrome b561
EM6_RS15205	COG1960	acyl-CoA dehydrogenase activity
EM6_RS15230	COG1686	Belongs to the peptidase S11 family
EM6_RS15240	COG1192	Involved in chromosome partitioning
EM6_RS15245	COG0024	Methionine aminopeptidase
EM6_RS15250	COG2003	Belongs to the UPF0758 family
EM6_RS15255	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
EM6_RS15260	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EM6_RS15270	COG3250	beta-galactosidase activity
EM6_RS15270	COG5297	Belongs to the glycosyl hydrolase family 6
EM6_RS15275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EM6_RS15295	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EM6_RS15300	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EM6_RS15305	COG0047	phosphoribosylformylglycinamidine synthase activity
EM6_RS15320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EM6_RS15340	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EM6_RS15345	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EM6_RS15350	COG1253	flavin adenine dinucleotide binding
EM6_RS15370	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EM6_RS15380	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EM6_RS15385	COG2032	superoxide dismutase activity
EM6_RS15390	COG0564	pseudouridine synthase activity
EM6_RS15420	COG0386	Belongs to the glutathione peroxidase family
EM6_RS15425	COG1396	sequence-specific DNA binding
EM6_RS15435	COG1741	Belongs to the pirin family
EM6_RS15460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EM6_RS15465	COG0629	single-stranded DNA binding
EM6_RS15480	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EM6_RS15500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EM6_RS15505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EM6_RS15510	COG5442	Flagellar protein FlaF
EM6_RS15520	COG0457	Tetratricopeptide repeat
EM6_RS15520	COG0859	PFAM glycosyl transferase family 9
EM6_RS15530	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EM6_RS15540	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EM6_RS15540	COG3743	rRNA binding
EM6_RS15550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EM6_RS15550	COG0574	Belongs to the PEP-utilizing enzyme family
EM6_RS15555	COG0751	glycine-tRNA ligase activity
EM6_RS15605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EM6_RS15635	COG0525	valine-tRNA ligase activity
EM6_RS15675	COG0784	Response regulator, receiver
EM6_RS15695	COG0546	phosphoglycolate phosphatase activity
EM6_RS15710	COG0537	adenosine 5'-monophosphoramidase activity
EM6_RS15715	COG0406	alpha-ribazole phosphatase activity
EM6_RS15720	COG5001	Diguanylate cyclase
EM6_RS15720	COG3300	MHYT domain
EM6_RS15735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EM6_RS15820	COG1668	transmembrane transport
EM6_RS15825	COG4152	abc transporter atp-binding protein
EM6_RS15830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EM6_RS15845	COG4585	Histidine kinase
EM6_RS15850	COG2197	response regulator
EM6_RS15865	COG4771	TonB-dependent receptor
EM6_RS15880	COG1297	OPT oligopeptide transporter protein
EM6_RS15885	COG4771	TonB-dependent receptor
EM6_RS15920	COG3590	peptidase
EM6_RS15935	COG0124	histidyl-tRNA synthetase
EM6_RS15945	COG2890	protein-(glutamine-N5) methyltransferase activity
EM6_RS15955	COG0527	aspartate kinase activity
EM6_RS15960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EM6_RS15965	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EM6_RS15980	COG3300	MHYT domain
EM6_RS15980	COG5001	Diguanylate cyclase
EM6_RS15985	COG0312	modulator of DNA gyrase
EM6_RS15990	COG0483	inositol monophosphate 1-phosphatase activity
EM6_RS16010	COG1132	(ABC) transporter
EM6_RS16020	COG1519	Transferase
EM6_RS16025	COG1663	tetraacyldisaccharide 4'-kinase activity
EM6_RS16040	COG0151	Belongs to the GarS family
EM6_RS16055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EM6_RS16060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EM6_RS16075	COG0742	ribosomal rna small subunit methyltransferase
EM6_RS16080	COG1187	pseudouridine synthase activity
EM6_RS16090	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EM6_RS16120	COG3250	beta-galactosidase activity
EM6_RS16185	COG3250	beta-galactosidase activity
EM6_RS16190	COG2971	BadF BadG BcrA BcrD
EM6_RS16210	COG2186	Transcriptional regulator
EM6_RS16215	COG2186	Transcriptional regulator
EM6_RS16240	COG1737	Transcriptional regulator
EM6_RS16250	COG3540	Alkaline phosphatase
EM6_RS16260	COG1028	Short-chain dehydrogenase reductase Sdr
EM6_RS16265	COG4948	Mandelate Racemase Muconate Lactonizing
EM6_RS16270	COG2186	Transcriptional regulator
EM6_RS16275	COG2814	Major facilitator Superfamily
EM6_RS16280	COG0754	glutathionylspermidine amidase activity
EM6_RS16350	COG1595	DNA-templated transcription, initiation
EM6_RS16375	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
EM6_RS16380	COG0415	Belongs to the DNA photolyase family
EM6_RS16395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EM6_RS16530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EM6_RS16530	COG0519	Catalyzes the synthesis of GMP from XMP
EM6_RS16540	COG4771	TonB-dependent receptor
EM6_RS16550	COG4957	zinc ion binding
EM6_RS16585	COG1396	sequence-specific DNA binding
EM6_RS16690	COG1396	sequence-specific DNA binding
EM6_RS16720	COG4962	Type ii secretion system protein e
EM6_RS16735	COG3451	type IV secretory pathway VirB4
EM6_RS16745	COG3846	protein secretion by the type IV secretion system
EM6_RS16760	COG2948	multi-organism process
EM6_RS16785	COG0840	transmembrane signaling receptor activity
EM6_RS16800	COG0667	Aldo Keto reductase
EM6_RS16830	COG1064	alcohol dehydrogenase
EM6_RS16845	COG2264	protein methyltransferase activity
EM6_RS16850	COG1733	regulation of RNA biosynthetic process
EM6_RS16855	COG1028	Short-chain dehydrogenase reductase Sdr
EM6_RS16865	COG0183	Belongs to the thiolase family
EM6_RS16870	COG0667	Aldo Keto reductase
EM6_RS16880	COG0667	Aldo Keto reductase
EM6_RS16885	COG1028	Short-chain dehydrogenase reductase Sdr
EM6_RS16890	COG1309	transcriptional regulator
EM6_RS16900	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
EM6_RS16905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EM6_RS16945	COG0776	regulation of translation
EM6_RS16950	COG4957	zinc ion binding
EM6_RS16980	COG2197	response regulator
EM6_RS16990	COG2204	response regulator
EM6_RS17050	COG2271	Major facilitator Superfamily
EM6_RS17075	COG1414	Transcriptional regulator
EM6_RS17085	COG0179	Fumarylacetoacetate (FAA) hydrolase
EM6_RS17100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EM6_RS17115	COG0840	transmembrane signaling receptor activity
EM6_RS17120	COG1192	Involved in chromosome partitioning
EM6_RS17135	COG3940	Belongs to the glycosyl hydrolase 43 family
EM6_RS17145	COG3718	enzyme involved in inositol metabolism
EM6_RS17155	COG3962	Belongs to the TPP enzyme family
EM6_RS17160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EM6_RS17170	COG0673	inositol 2-dehydrogenase activity
EM6_RS17175	COG3537	Alpha-1,2-mannosidase
EM6_RS17180	COG1172	Belongs to the binding-protein-dependent transport system permease family
EM6_RS17185	COG1129	ABC transporter
EM6_RS17190	COG1879	ABC-type sugar transport system periplasmic component
EM6_RS17200	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EM6_RS17205	COG1845	cytochrome c oxidase, subunit III
EM6_RS17210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EM6_RS17215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor