locus-tag	class	description
LH365_RS00025	COG0494	nUDIX hydrolase
LH365_RS00045	COG1959	2 iron, 2 sulfur cluster binding
LH365_RS00050	COG4221	oxidoreductase activity
LH365_RS00055	COG2095	MarC family integral membrane protein
LH365_RS00070	COG0501	Belongs to the peptidase M48B family
LH365_RS00080	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LH365_RS00090	COG0138	bifunctional purine biosynthesis protein purh
LH365_RS00110	COG0180	Tryptophanyl-tRNA synthetase
LH365_RS00115	COG0728	peptidoglycan biosynthetic process
LH365_RS00120	COG0488	(ABC) transporter
LH365_RS00130	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LH365_RS00135	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LH365_RS00140	COG0281	malic enzyme
LH365_RS00140	COG0280	phosphate acetyltransferase
LH365_RS00145	COG2814	Major facilitator Superfamily
LH365_RS00150	COG0784	Response regulator, receiver
LH365_RS00150	COG2205	protein histidine kinase activity
LH365_RS00150	COG5002	protein histidine kinase activity
LH365_RS00220	COG0189	ligase activity
LH365_RS00230	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LH365_RS00240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LH365_RS00245	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LH365_RS00255	COG3655	Transcriptional regulator
LH365_RS00260	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LH365_RS00290	COG0412	Dienelactone hydrolase
LH365_RS00295	COG0443	Heat shock 70 kDa protein
LH365_RS00300	COG0484	heat shock protein binding
LH365_RS00305	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LH365_RS00315	COG0756	dUTP diphosphatase activity
LH365_RS00320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LH365_RS00330	COG5001	Diguanylate cyclase
LH365_RS00350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LH365_RS00375	COG0802	atpase or kinase
LH365_RS00380	COG3178	'Phosphotransferase
LH365_RS00385	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LH365_RS00395	COG1074	ATP-dependent DNA helicase activity
LH365_RS00405	COG1597	lipid kinase activity
LH365_RS00410	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LH365_RS00425	COG1674	ftsk spoiiie
LH365_RS00430	COG0251	oxidation-reduction process
LH365_RS00435	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LH365_RS00440	COG4953	penicillin-binding protein 1C
LH365_RS00455	COG2373	Large extracellular alpha-helical protein
LH365_RS00460	COG0745	RESPONSE REGULATOR receiver
LH365_RS00465	COG4771	TonB-dependent receptor
LH365_RS00470	COG0336	Belongs to the RNA methyltransferase TrmD family
LH365_RS00475	COG0335	large ribosomal subunit rRNA binding
LH365_RS00485	COG2133	pyrroloquinoline quinone binding
LH365_RS00490	COG4206	TonB-dependent receptor
LH365_RS00500	COG1185	polyribonucleotide nucleotidyltransferase activity
LH365_RS00505	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LH365_RS00510	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LH365_RS00535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LH365_RS00535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LH365_RS00550	COG0779	Required for maturation of 30S ribosomal subunits
LH365_RS00570	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LH365_RS00575	COG1396	sequence-specific DNA binding
LH365_RS00580	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LH365_RS00585	COG1253	flavin adenine dinucleotide binding
LH365_RS00590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LH365_RS00595	COG1702	phosphate starvation-inducible protein PhoH
LH365_RS00600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LH365_RS00630	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LH365_RS00645	COG0433	COG0433 Predicted ATPase
LH365_RS00665	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LH365_RS00670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LH365_RS00675	COG0237	dephospho-CoA kinase activity
LH365_RS00685	COG0424	maF-like protein
LH365_RS00690	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LH365_RS00705	COG1981	membrane
LH365_RS00710	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LH365_RS00720	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LH365_RS00775	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LH365_RS00785	COG0745	RESPONSE REGULATOR receiver
LH365_RS00800	COG2205	protein histidine kinase activity
LH365_RS00810	COG0640	Transcriptional regulator
LH365_RS00825	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LH365_RS00840	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
LH365_RS00855	COG0436	Aminotransferase
LH365_RS00870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LH365_RS00880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LH365_RS00885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LH365_RS00890	COG1940	carbohydrate kinase activity
LH365_RS00890	COG1846	Transcriptional regulator
LH365_RS00910	COG0583	DNA-binding transcription factor activity
LH365_RS00920	COG2375	cellular response to nickel ion
LH365_RS00925	COG1695	Transcriptional regulator
LH365_RS00930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LH365_RS00935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LH365_RS00940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LH365_RS00950	COG0071	Belongs to the small heat shock protein (HSP20) family
LH365_RS00955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH365_RS00960	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LH365_RS00965	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LH365_RS00970	COG1137	ATPase activity
LH365_RS00985	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LH365_RS00990	COG0477	Major facilitator Superfamily
LH365_RS01015	COG0633	Ferredoxin
LH365_RS01025	COG1053	succinate dehydrogenase
LH365_RS01035	COG2009	succinate dehydrogenase
LH365_RS01090	COG2353	YceI-like domain
LH365_RS01115	COG2814	Major facilitator Superfamily
LH365_RS01120	COG0045	succinate-CoA ligase (ADP-forming) activity
LH365_RS01125	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LH365_RS01140	COG0508	dehydrogenase complex catalyzes the overall conversion of
LH365_RS01160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH365_RS01165	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LH365_RS01190	COG1253	flavin adenine dinucleotide binding
LH365_RS01200	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LH365_RS01205	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LH365_RS01210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LH365_RS01215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LH365_RS01230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LH365_RS01235	COG0552	protein localization to endoplasmic reticulum
LH365_RS01240	COG2917	probably involved in intracellular septation
LH365_RS01255	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_RS01260	COG3639	organic phosphonate transmembrane transporter activity
LH365_RS01265	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LH365_RS01270	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LH365_RS01280	COG1959	2 iron, 2 sulfur cluster binding
LH365_RS01285	COG0492	ferredoxin-NADP+ reductase activity
LH365_RS01290	COG1899	peptidyl-lysine modification to peptidyl-hypusine
LH365_RS01300	COG1309	transcriptional regulator
LH365_RS01320	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LH365_RS01325	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LH365_RS01335	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LH365_RS01340	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LH365_RS01345	COG5507	3-demethylubiquinone-9 3-methyltransferase
LH365_RS01350	COG5507	3-demethylubiquinone-9 3-methyltransferase
LH365_RS01370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LH365_RS01385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LH365_RS01395	COG2124	cytochrome p450
LH365_RS01400	COG2204	response regulator
LH365_RS01405	COG4251	negative regulation of phosphorylation
LH365_RS01410	COG3401	FG-GAP repeat protein
LH365_RS01430	COG0670	Belongs to the BI1 family
LH365_RS01440	COG1785	Belongs to the alkaline phosphatase family
LH365_RS01445	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LH365_RS01455	COG0745	RESPONSE REGULATOR receiver
LH365_RS01460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LH365_RS01515	COG4964	Belongs to the GSP D family
LH365_RS01565	COG0793	Belongs to the peptidase S41A family
LH365_RS01575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LH365_RS01580	COG0799	negative regulation of ribosome biogenesis
LH365_RS01585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LH365_RS01590	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LH365_RS01605	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LH365_RS01610	COG0523	cobalamin synthesis protein
LH365_RS01640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH365_RS01645	COG2885	chlorophyll binding
LH365_RS01655	COG1086	Polysaccharide biosynthesis protein
LH365_RS01660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LH365_RS01665	COG2089	acid synthase
LH365_RS01685	COG0243	molybdopterin cofactor binding
LH365_RS01690	COG1073	alpha beta
LH365_RS01695	COG0303	'Molybdopterin
LH365_RS01700	COG0521	Mo-molybdopterin cofactor biosynthetic process
LH365_RS01705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LH365_RS01710	COG2272	Belongs to the type-B carboxylesterase lipase family
LH365_RS01725	COG0246	Mannitol dehydrogenase
LH365_RS01730	COG2721	sulfolactate sulfo-lyase activity
LH365_RS01735	COG1609	Transcriptional regulator
LH365_RS01740	COG1904	glucuronate isomerase
LH365_RS01750	COG4221	oxidoreductase activity
LH365_RS01775	COG2852	Protein conserved in bacteria
LH365_RS01780	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LH365_RS01785	COG4133	protoheme IX ABC transporter activity
LH365_RS01790	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LH365_RS01795	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LH365_RS01805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH365_RS01810	COG0077	Prephenate dehydratase
LH365_RS01810	COG1605	Chorismate mutase
LH365_RS01825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LH365_RS01850	COG2186	Transcriptional regulator
LH365_RS01860	COG1396	sequence-specific DNA binding
LH365_RS01860	COG3800	Transcriptional regulator
LH365_RS01870	COG2224	Isocitrate lyase
LH365_RS01890	COG2852	Protein conserved in bacteria
LH365_RS01895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LH365_RS01895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LH365_RS01930	COG0745	RESPONSE REGULATOR receiver
LH365_RS01935	COG2205	protein histidine kinase activity
LH365_RS01940	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LH365_RS01945	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH365_RS01945	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH365_RS01950	COG2169	Transcriptional regulator
LH365_RS01950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LH365_RS01975	COG0121	glutamine amidotransferase
LH365_RS01980	COG1764	response to oxidative stress
LH365_RS02010	COG0730	response to heat
LH365_RS02020	COG1199	ATP-dependent helicase activity
LH365_RS02025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH365_RS02040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LH365_RS02050	COG1309	transcriptional regulator
LH365_RS02080	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH365_RS02090	COG2311	Membrane
LH365_RS02095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH365_RS02100	COG0165	Argininosuccinate lyase
LH365_RS02110	COG0019	diaminopimelate decarboxylase activity
LH365_RS02135	COG0717	Belongs to the dCTP deaminase family
LH365_RS02195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LH365_RS02200	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LH365_RS02205	COG0612	Peptidase, M16
LH365_RS02215	COG1462	curli production assembly transport component CsgG
LH365_RS02265	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LH365_RS02275	COG2884	Cell division ATP-binding protein ftsE
LH365_RS02290	COG0204	Acyl-transferase
LH365_RS02315	COG0653	protein targeting
LH365_RS02320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH365_RS02325	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LH365_RS02330	COG0494	nUDIX hydrolase
LH365_RS02340	COG2226	methyltransferase
LH365_RS02345	COG1040	competence protein
LH365_RS02350	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LH365_RS02355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LH365_RS02370	COG4232	protein-disulfide reductase activity
LH365_RS02375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LH365_RS02385	COG0527	aspartate kinase activity
LH365_RS02395	COG2890	protein-(glutamine-N5) methyltransferase activity
LH365_RS02415	COG0124	histidyl-tRNA synthetase
LH365_RS02430	COG3590	peptidase
LH365_RS02465	COG3152	Membrane
LH365_RS02485	COG2852	Protein conserved in bacteria
LH365_RS02495	COG0459	protein refolding
LH365_RS02505	COG3867	Arabinogalactan endo-beta-1,4-galactanase
LH365_RS02545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LH365_RS02565	COG0714	Associated with various cellular activities
LH365_RS02590	COG4191	Histidine kinase
LH365_RS02590	COG0784	Response regulator, receiver
LH365_RS02610	COG1522	sequence-specific DNA binding
LH365_RS02615	COG0438	transferase activity, transferring glycosyl groups
LH365_RS02625	COG0482	sulfurtransferase activity
LH365_RS02650	COG1749	Flagellar hook protein flgE
LH365_RS02660	COG1766	The M ring may be actively involved in energy transduction
LH365_RS02665	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LH365_RS02675	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LH365_RS02680	COG2204	response regulator
LH365_RS02685	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LH365_RS02695	COG2382	esterase
LH365_RS02695	COG3507	Belongs to the glycosyl hydrolase 43 family
LH365_RS02695	COG3693	PFAM glycoside hydrolase, family 10
LH365_RS02760	COG2201	protein-glutamate methylesterase activity
LH365_RS02765	COG2201	protein-glutamate methylesterase activity
LH365_RS02775	COG2198	Histidine kinase
LH365_RS02775	COG0643	Histidine kinase
LH365_RS02775	COG0784	Response regulator, receiver
LH365_RS02795	COG4957	zinc ion binding
LH365_RS02805	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LH365_RS02820	COG2166	iron-sulfur cluster assembly
LH365_RS02825	COG2205	protein histidine kinase activity
LH365_RS02825	COG2202	Pas domain
LH365_RS02830	COG2205	protein histidine kinase activity
LH365_RS02850	COG2814	Major facilitator Superfamily
LH365_RS02855	COG1272	protein, Hemolysin III
LH365_RS02860	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LH365_RS02885	COG0471	metal ion transport
LH365_RS02885	COG3273	potassium ion transport
LH365_RS02890	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LH365_RS02895	COG0746	molybdenum cofactor guanylyltransferase activity
LH365_RS02900	COG2223	nitrite transmembrane transporter activity
LH365_RS02910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH365_RS02910	COG1116	anion transmembrane transporter activity
LH365_RS02915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LH365_RS02925	COG0243	molybdopterin cofactor binding
LH365_RS02930	COG1116	anion transmembrane transporter activity
LH365_RS02935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH365_RS02940	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH365_RS02950	COG3507	Belongs to the glycosyl hydrolase 43 family
LH365_RS02960	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LH365_RS02975	COG2271	Major facilitator Superfamily
LH365_RS02980	COG3507	Belongs to the glycosyl hydrolase 43 family
LH365_RS03035	COG2217	Heavy metal translocating P-type atpase
LH365_RS03040	COG2072	flavoprotein involved in K transport
LH365_RS03045	COG1558	bacterial-type flagellum-dependent cell motility
LH365_RS03050	COG1396	sequence-specific DNA binding
LH365_RS03075	COG2217	Heavy metal translocating P-type atpase
LH365_RS03140	COG0776	regulation of translation
LH365_RS03150	COG1396	sequence-specific DNA binding
LH365_RS03205	COG2132	Multicopper oxidase
LH365_RS03210	COG0789	Transcriptional regulator
LH365_RS03215	COG0640	Transcriptional regulator
LH365_RS03220	COG1230	cation diffusion facilitator family transporter
LH365_RS03225	COG0789	Transcriptional regulator
LH365_RS03295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LH365_RS03300	COG3577	Aspartyl protease
LH365_RS03320	COG0840	transmembrane signaling receptor activity
LH365_RS03330	COG0556	nucleotide-excision repair
LH365_RS03355	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LH365_RS03365	COG0492	ferredoxin-NADP+ reductase activity
LH365_RS03395	COG0640	Transcriptional regulator
LH365_RS03405	COG2154	pterin-4-alpha-carbinolamine dehydratase
LH365_RS03410	COG3186	Phenylalanine-4-hydroxylase
LH365_RS03435	COG5002	protein histidine kinase activity
LH365_RS03445	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LH365_RS03450	COG0784	Response regulator, receiver
LH365_RS03450	COG2205	protein histidine kinase activity
LH365_RS03450	COG2198	Histidine kinase
LH365_RS03470	COG0655	NAD(P)H dehydrogenase (quinone) activity
LH365_RS03480	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LH365_RS03490	COG0450	alkyl hydroperoxide reductase
LH365_RS03540	COG0473	3-isopropylmalate dehydrogenase activity
LH365_RS03545	COG0066	3-isopropylmalate dehydratase activity
LH365_RS03550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LH365_RS03560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH365_RS03575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LH365_RS03585	COG0129	dihydroxy-acid dehydratase activity
LH365_RS03610	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LH365_RS03615	COG3162	membrane
LH365_RS03670	COG0181	hydroxymethylbilane synthase activity
LH365_RS03675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LH365_RS03680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LH365_RS03690	COG3609	addiction module antidote protein, CC2985 family
LH365_RS03705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LH365_RS03730	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LH365_RS03745	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LH365_RS03755	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LH365_RS03770	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LH365_RS03785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LH365_RS03805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LH365_RS03820	COG0189	ligase activity
LH365_RS03820	COG4067	protein conserved in archaea
LH365_RS03855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LH365_RS03865	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LH365_RS03885	COG4948	Mandelate Racemase Muconate Lactonizing
LH365_RS03900	COG3384	dioxygenase
LH365_RS03905	COG2353	YceI-like domain
LH365_RS03910	COG4771	TonB-dependent receptor
LH365_RS03945	COG0625	glutathione transferase activity
LH365_RS03955	COG0442	prolyl-tRNA aminoacylation
LH365_RS03970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LH365_RS03975	COG0385	Bile acid
LH365_RS03995	COG4948	Mandelate Racemase Muconate Lactonizing
LH365_RS04030	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LH365_RS04035	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LH365_RS04040	COG0131	Imidazoleglycerol-phosphate dehydratase
LH365_RS04040	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LH365_RS04050	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LH365_RS04060	COG0443	Heat shock 70 kDa protein
LH365_RS04080	COG1704	LemA family
LH365_RS04115	COG1522	sequence-specific DNA binding
LH365_RS04155	COG2885	chlorophyll binding
LH365_RS04160	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LH365_RS04170	COG2957	Belongs to the agmatine deiminase family
LH365_RS04185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LH365_RS04190	COG0840	transmembrane signaling receptor activity
LH365_RS04215	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LH365_RS04220	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LH365_RS04230	COG1322	Protein conserved in bacteria
LH365_RS04245	COG0242	peptide deformylase activity
LH365_RS04255	COG0101	tRNA pseudouridine synthase activity
LH365_RS04290	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH365_RS04300	COG0598	Magnesium transport protein CorA
LH365_RS04315	COG4206	TonB-dependent receptor
LH365_RS04335	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LH365_RS04340	COG3300	MHYT domain
LH365_RS04340	COG5001	Diguanylate cyclase
LH365_RS04350	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LH365_RS04360	COG0588	phosphoglycerate mutase activity
LH365_RS04365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LH365_RS04365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LH365_RS04380	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LH365_RS04385	COG4988	ABC transporter
LH365_RS04390	COG1271	oxidase subunit
LH365_RS04395	COG1294	oxidase, subunit
LH365_RS04405	COG1086	Polysaccharide biosynthesis protein
LH365_RS04415	COG0314	molybdopterin synthase activity
LH365_RS04420	COG0315	cyclic pyranopterin monophosphate synthase activity
LH365_RS04425	COG2264	protein methyltransferase activity
LH365_RS04435	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LH365_RS04450	COG0366	Alpha amylase catalytic
LH365_RS04460	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LH365_RS04475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LH365_RS04490	COG0051	transcription antitermination factor activity, RNA binding
LH365_RS04495	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LH365_RS04505	COG0089	rRNA binding
LH365_RS04510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LH365_RS04515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LH365_RS04520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LH365_RS04525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LH365_RS04535	COG0255	Belongs to the universal ribosomal protein uL29 family
LH365_RS04540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LH365_RS04545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LH365_RS04560	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LH365_RS04580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LH365_RS04590	COG0200	Binds to the 23S rRNA
LH365_RS04595	COG0201	protein transport
LH365_RS04610	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LH365_RS04620	COG0203	ribosomal protein L17
LH365_RS04645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH365_RS04660	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LH365_RS04715	COG1956	GAF domain-containing protein
LH365_RS04730	COG0823	Involved in the tonB-independent uptake of proteins
LH365_RS04730	COG1506	peptidase
LH365_RS04760	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LH365_RS04765	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LH365_RS04770	COG4771	TonB-dependent receptor
LH365_RS04780	COG0318	PFAM AMP-dependent synthetase and ligase
LH365_RS04790	COG3237	CsbD-like
LH365_RS04820	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_RS04860	COG1994	Peptidase M50
LH365_RS04865	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LH365_RS04865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH365_RS04875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH365_RS04880	COG0174	glutamine synthetase
LH365_RS04900	COG3345	alpha-galactosidase
LH365_RS04950	COG1396	sequence-specific DNA binding
LH365_RS04995	COG1051	belongs to the nudix hydrolase family
LH365_RS05010	COG0702	epimerase
LH365_RS05015	COG1733	regulation of RNA biosynthetic process
LH365_RS05020	COG0800	Aldolase
LH365_RS05025	COG3734	2-keto-3-deoxy-galactonokinase
LH365_RS05035	COG0183	Belongs to the thiolase family
LH365_RS05040	COG1024	Enoyl-CoA hydratase
LH365_RS05040	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH365_RS05090	COG0753	catalase activity
LH365_RS05115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LH365_RS05120	COG0640	Transcriptional regulator
LH365_RS05125	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LH365_RS05135	COG0387	Pfam Sodium calcium exchanger
LH365_RS05150	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LH365_RS05155	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LH365_RS05160	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LH365_RS05165	COG2205	protein histidine kinase activity
LH365_RS05170	COG0745	RESPONSE REGULATOR receiver
LH365_RS05185	COG1702	phosphate starvation-inducible protein PhoH
LH365_RS05210	COG0328	RNA-DNA hybrid ribonuclease activity
LH365_RS05215	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LH365_RS05235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LH365_RS05245	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LH365_RS05245	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LH365_RS05250	COG4771	TonB-dependent receptor
LH365_RS05325	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LH365_RS05350	COG2951	lytic endotransglycosylase activity
LH365_RS05360	COG0848	biopolymer transport protein
LH365_RS05390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH365_RS05390	COG2022	thiamine diphosphate biosynthetic process
LH365_RS05415	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LH365_RS05430	COG2321	neutral zinc metallopeptidase
LH365_RS05435	COG1309	transcriptional regulator
LH365_RS05450	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LH365_RS05460	COG4974	Belongs to the 'phage' integrase family
LH365_RS05480	COG0668	transmembrane transport
LH365_RS05490	COG0590	tRNA wobble adenosine to inosine editing
LH365_RS05495	COG1187	pseudouridine synthase activity
LH365_RS05500	COG0742	ribosomal rna small subunit methyltransferase
LH365_RS05525	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LH365_RS05530	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LH365_RS05540	COG0196	riboflavin kinase activity
LH365_RS05550	COG0745	RESPONSE REGULATOR receiver
LH365_RS05555	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LH365_RS05575	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LH365_RS05580	COG2201	protein-glutamate methylesterase activity
LH365_RS05600	COG0784	Response regulator, receiver
LH365_RS05600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH365_RS05600	COG2198	Histidine kinase
LH365_RS05600	COG2205	protein histidine kinase activity
LH365_RS05605	COG0745	RESPONSE REGULATOR receiver
LH365_RS05615	COG0151	Belongs to the GarS family
LH365_RS05625	COG1663	tetraacyldisaccharide 4'-kinase activity
LH365_RS05630	COG1519	Transferase
LH365_RS05640	COG1132	(ABC) transporter
LH365_RS05665	COG0483	inositol monophosphate 1-phosphatase activity
LH365_RS05670	COG0312	modulator of DNA gyrase
LH365_RS05675	COG5001	Diguanylate cyclase
LH365_RS05695	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LH365_RS05725	COG0431	NADPH-dependent FMN reductase
LH365_RS05735	COG1573	uracil-dna glycosylase
LH365_RS05745	COG1187	pseudouridine synthase activity
LH365_RS05750	COG0519	Catalyzes the synthesis of GMP from XMP
LH365_RS05765	COG4771	TonB-dependent receptor
LH365_RS05775	COG1595	DNA-templated transcription, initiation
LH365_RS05800	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LH365_RS05815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH365_RS05850	COG0557	exoribonuclease II activity
LH365_RS05855	COG2852	Protein conserved in bacteria
LH365_RS05860	COG1754	DNA topoisomerase type I activity
LH365_RS05860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LH365_RS05875	COG0758	DNA mediated transformation
LH365_RS05875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LH365_RS05885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LH365_RS05890	COG0540	Belongs to the ATCase OTCase family
LH365_RS05895	COG1064	alcohol dehydrogenase
LH365_RS05905	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LH365_RS05920	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LH365_RS05925	COG0154	amidase activity
LH365_RS05935	COG4771	TonB-dependent receptor
LH365_RS05940	COG1297	OPT oligopeptide transporter protein
LH365_RS05950	COG4771	TonB-dependent receptor
LH365_RS05965	COG2197	response regulator
LH365_RS05970	COG4585	Histidine kinase
LH365_RS05985	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LH365_RS05995	COG4152	abc transporter atp-binding protein
LH365_RS06000	COG1668	transmembrane transport
LH365_RS06070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH365_RS06080	COG5001	Diguanylate cyclase
LH365_RS06080	COG3300	MHYT domain
LH365_RS06085	COG0406	alpha-ribazole phosphatase activity
LH365_RS06090	COG0537	adenosine 5'-monophosphoramidase activity
LH365_RS06095	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LH365_RS06130	COG0784	Response regulator, receiver
LH365_RS06175	COG0525	valine-tRNA ligase activity
LH365_RS06195	COG0463	Glycosyl transferase, family 2
LH365_RS06205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LH365_RS06255	COG0751	glycine-tRNA ligase activity
LH365_RS06260	COG0574	Belongs to the PEP-utilizing enzyme family
LH365_RS06260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LH365_RS06280	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LH365_RS06290	COG0859	PFAM glycosyl transferase family 9
LH365_RS06290	COG0457	Tetratricopeptide repeat
LH365_RS06300	COG5442	Flagellar protein FlaF
LH365_RS06310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LH365_RS06315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LH365_RS06330	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH365_RS06345	COG0629	single-stranded DNA binding
LH365_RS06360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LH365_RS06385	COG1741	Belongs to the pirin family
LH365_RS06395	COG1396	sequence-specific DNA binding
LH365_RS06400	COG0386	Belongs to the glutathione peroxidase family
LH365_RS06410	COG3250	beta-galactosidase activity
LH365_RS06435	COG0564	pseudouridine synthase activity
LH365_RS06440	COG2032	superoxide dismutase activity
LH365_RS06445	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LH365_RS06450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LH365_RS06470	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LH365_RS06485	COG1253	flavin adenine dinucleotide binding
LH365_RS06490	COG0840	transmembrane signaling receptor activity
LH365_RS06495	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LH365_RS06505	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LH365_RS06525	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LH365_RS06530	COG0047	phosphoribosylformylglycinamidine synthase activity
LH365_RS06535	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LH365_RS06540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LH365_RS06560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LH365_RS06565	COG2273	Hydrolase Family 16
LH365_RS06565	COG5297	Belongs to the glycosyl hydrolase family 6
LH365_RS06575	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LH365_RS06580	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LH365_RS06585	COG2003	Belongs to the UPF0758 family
LH365_RS06615	COG0556	nucleotide-excision repair
LH365_RS06625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LH365_RS06645	COG0583	DNA-binding transcription factor activity
LH365_RS06665	COG3701	Conjugal transfer protein
LH365_RS06670	COG3846	protein secretion by the type IV secretion system
LH365_RS06685	COG3451	type IV secretory pathway VirB4
LH365_RS06700	COG4962	Type ii secretion system protein e
LH365_RS06730	COG0739	heme binding
LH365_RS06730	COG0741	lytic transglycosylase activity
LH365_RS06730	COG1196	nuclear chromosome segregation
LH365_RS06755	COG1192	Involved in chromosome partitioning
LH365_RS06790	COG5489	Protein of unknown function (DUF736)
LH365_RS06805	COG3012	SEC-C Motif Domain Protein
LH365_RS06840	COG1475	DNA binding
LH365_RS06870	COG2176	DNA-directed DNA polymerase activity
LH365_RS06885	COG2003	Belongs to the UPF0758 family
LH365_RS06890	COG0024	Methionine aminopeptidase
LH365_RS06895	COG0489	protein tyrosine kinase activity
LH365_RS06910	COG1686	Belongs to the peptidase S11 family
LH365_RS06935	COG1960	acyl-CoA dehydrogenase activity
LH365_RS06940	COG3038	cytochrome b561
LH365_RS06945	COG0009	L-threonylcarbamoyladenylate synthase
LH365_RS06950	COG3022	response to hydroperoxide
LH365_RS06955	COG0745	RESPONSE REGULATOR receiver
LH365_RS06965	COG0277	FAD linked oxidase domain protein
LH365_RS06970	COG1051	belongs to the nudix hydrolase family
LH365_RS06975	COG0330	HflC and HflK could
LH365_RS06980	COG1585	Membrane protein implicated in regulation of membrane protease activity
LH365_RS06985	COG0235	Class ii aldolase
LH365_RS06995	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LH365_RS07000	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LH365_RS07005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH365_RS07025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LH365_RS07040	COG0488	(ABC) transporter
LH365_RS07050	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LH365_RS07055	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LH365_RS07060	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LH365_RS07070	COG0248	Ppx GppA phosphatase
LH365_RS07085	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LH365_RS07100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LH365_RS07120	COG0439	Biotin carboxylase
LH365_RS07155	COG0501	Belongs to the peptidase M48B family
LH365_RS07160	COG1530	ribonuclease E activity
LH365_RS07170	COG1388	LysM domain
LH365_RS07170	COG0860	N-Acetylmuramoyl-L-alanine amidase
LH365_RS07175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LH365_RS07185	COG1295	ribonuclease BN
LH365_RS07195	COG0739	heme binding
LH365_RS07200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LH365_RS07215	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LH365_RS07220	COG2945	thiolester hydrolase activity
LH365_RS07225	COG1959	2 iron, 2 sulfur cluster binding
LH365_RS07230	COG1104	cysteine desulfurase activity
LH365_RS07235	COG0719	Fe-S assembly protein
LH365_RS07240	COG0396	ATPase activity
LH365_RS07245	COG0719	Fe-S assembly protein
LH365_RS07250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LH365_RS07260	COG0316	Belongs to the HesB IscA family
LH365_RS07290	COG0513	Belongs to the DEAD box helicase family
LH365_RS07295	COG0187	DNA topoisomerase II activity
LH365_RS07310	COG0004	ammonium transporteR
LH365_RS07315	COG0174	glutamine synthetase
LH365_RS07320	COG0347	Belongs to the P(II) protein family
LH365_RS07330	COG0359	binds to the 23S rRNA
LH365_RS07340	COG0360	Binds together with S18 to 16S ribosomal RNA
LH365_RS07345	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LH365_RS07355	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LH365_RS07365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LH365_RS07370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LH365_RS07375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LH365_RS07380	COG1561	YicC-like family, N-terminal region
LH365_RS07385	COG0194	GDP metabolic process
LH365_RS07390	COG3474	cytochrome
LH365_RS07425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH365_RS07455	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH365_RS07460	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH365_RS07465	COG0649	NAD binding
LH365_RS07480	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LH365_RS07485	COG2314	TM2 domain
LH365_RS07495	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LH365_RS07500	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH365_RS07525	COG1007	ATP synthesis coupled electron transport
LH365_RS07535	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LH365_RS07545	COG3243	poly(R)-hydroxyalkanoic acid synthase
LH365_RS07555	COG1494	fructose-1,6-bisphosphatase
LH365_RS07560	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LH365_RS07560	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LH365_RS07575	COG1278	Cold shock
LH365_RS07615	COG1612	heme a metabolic process
LH365_RS07625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LH365_RS07630	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LH365_RS07655	COG1136	(ABC) transporter
LH365_RS07665	COG0052	Belongs to the universal ribosomal protein uS2 family
LH365_RS07675	COG0528	UMP kinase activity
LH365_RS07680	COG0233	cytoplasmic translational termination
LH365_RS07685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LH365_RS07690	COG4589	Belongs to the CDS family
LH365_RS07700	COG0750	zinc metalloprotease
LH365_RS07705	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH365_RS07715	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LH365_RS07720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LH365_RS07730	COG3494	Protein of unknown function (DUF1009)
LH365_RS07735	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LH365_RS07740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LH365_RS07745	COG0372	Belongs to the citrate synthase family
LH365_RS07750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH365_RS07755	COG2333	competence protein COMEC
LH365_RS07755	COG0658	competence protein
LH365_RS07760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LH365_RS07765	COG0134	indole-3-glycerol-phosphate synthase activity
LH365_RS07785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LH365_RS07800	COG2204	response regulator
LH365_RS07805	COG5000	phosphorelay sensor kinase activity
LH365_RS07820	COG0321	lipoyl(octanoyl) transferase activity
LH365_RS07820	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LH365_RS07825	COG0084	hydrolase, TatD family'
LH365_RS07830	COG0470	DNA polymerase III
LH365_RS07835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LH365_RS07875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LH365_RS07880	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LH365_RS07885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LH365_RS07900	COG0463	Glycosyl transferase, family 2
LH365_RS07905	COG0415	Belongs to the DNA photolyase family
LH365_RS07910	COG2897	thiosulfate sulfurtransferase activity
LH365_RS07915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH365_RS07930	COG0251	oxidation-reduction process
LH365_RS07940	COG0504	CTP synthase activity
LH365_RS07945	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LH365_RS07950	COG0149	triose-phosphate isomerase activity
LH365_RS07960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LH365_RS07970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LH365_RS07970	COG4651	solute:proton antiporter activity
LH365_RS07980	COG3956	TIGRFAM MazG family protein
LH365_RS07985	COG0823	Involved in the tonB-independent uptake of proteins
LH365_RS07990	COG1733	regulation of RNA biosynthetic process
LH365_RS07995	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LH365_RS08000	COG1058	Belongs to the CinA family
LH365_RS08000	COG1546	Belongs to the CinA family
LH365_RS08040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH365_RS08045	COG0508	dehydrogenase complex catalyzes the overall conversion of
LH365_RS08050	COG0022	dehydrogenase e1 component
LH365_RS08050	COG0508	dehydrogenase complex catalyzes the overall conversion of
LH365_RS08055	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LH365_RS08060	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LH365_RS08065	COG0148	phosphopyruvate hydratase activity
LH365_RS08070	COG0546	phosphoglycolate phosphatase activity
LH365_RS08100	COG0776	regulation of translation
LH365_RS08105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LH365_RS08110	COG0416	fatty acid biosynthetic process
LH365_RS08130	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LH365_RS08140	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LH365_RS08150	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LH365_RS08175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LH365_RS08190	COG0156	8-amino-7-oxononanoate synthase activity
LH365_RS08200	COG0113	porphobilinogen synthase activity
LH365_RS08210	COG2084	Dehydrogenase
LH365_RS08215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LH365_RS08220	COG1360	Flagellar Motor Protein
LH365_RS08225	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LH365_RS08230	COG3932	Exopolysaccharide synthesis, ExoD
LH365_RS08235	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LH365_RS08250	COG1381	Involved in DNA repair and RecF pathway recombination
LH365_RS08265	COG0681	Belongs to the peptidase S26 family
LH365_RS08270	COG0736	holo-[acyl-carrier-protein] synthase activity
LH365_RS08275	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LH365_RS08290	COG1758	RNA polymerase activity
LH365_RS08300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LH365_RS08300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LH365_RS08320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH365_RS08330	COG0840	transmembrane signaling receptor activity
LH365_RS08335	COG1120	ATPase activity
LH365_RS08340	COG4139	cobalamin transport
LH365_RS08355	COG0116	Belongs to the methyltransferase superfamily
LH365_RS08355	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LH365_RS08360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LH365_RS08380	COG1643	Atp-dependent helicase
LH365_RS08385	COG0531	amino acid
LH365_RS08390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH365_RS08400	COG2081	HI0933 family
LH365_RS08405	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LH365_RS08425	COG0222	ribosome binding
LH365_RS08430	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LH365_RS08435	COG3813	Protein conserved in bacteria
LH365_RS08440	COG4977	sequence-specific DNA binding
LH365_RS08455	COG0081	regulation of translation
LH365_RS08460	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LH365_RS08470	COG0250	Participates in transcription elongation, termination and antitermination
LH365_RS08500	COG3152	Membrane
LH365_RS08505	COG0412	Dienelactone hydrolase
LH365_RS08510	COG0861	Integral membrane protein TerC family
LH365_RS08515	COG4106	trans-aconitate 2-methyltransferase activity
LH365_RS08520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LH365_RS08535	COG3152	Membrane
LH365_RS08555	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LH365_RS08575	COG1301	dicarboxylic acid transport
LH365_RS08610	COG0305	Participates in initiation and elongation during chromosome replication
LH365_RS08625	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LH365_RS08630	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_RS08645	COG1160	GTP binding
LH365_RS08660	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LH365_RS08670	COG1595	DNA-templated transcription, initiation
LH365_RS08685	COG1393	Belongs to the ArsC family
LH365_RS08695	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LH365_RS08730	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LH365_RS08755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LH365_RS08760	COG0436	Aminotransferase
LH365_RS08770	COG0343	queuine tRNA-ribosyltransferase activity
LH365_RS08790	COG0248	Ppx GppA phosphatase
LH365_RS08795	COG0602	queuosine metabolic process
LH365_RS08840	COG1960	acyl-CoA dehydrogenase activity
LH365_RS08850	COG1678	Uncharacterized ACR, COG1678
LH365_RS08855	COG0584	glycerophosphoryl diester phosphodiesterase
LH365_RS08865	COG0612	Peptidase, M16
LH365_RS08870	COG3346	SURF1 family
LH365_RS08880	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
LH365_RS08890	COG0109	protoheme IX farnesyltransferase activity
LH365_RS08895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LH365_RS08905	COG0312	modulator of DNA gyrase
LH365_RS08915	COG3104	oligopeptide transport
LH365_RS08955	COG1741	Belongs to the pirin family
LH365_RS08970	COG1054	Belongs to the UPF0176 family
LH365_RS08975	COG0616	signal peptide processing
LH365_RS09010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH365_RS09025	COG1706	bacterial-type flagellum-dependent cell motility
LH365_RS09045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LH365_RS09050	COG3338	carbonate dehydratase activity
LH365_RS09065	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LH365_RS09085	COG1862	Preprotein translocase
LH365_RS09110	COG0784	Response regulator, receiver
LH365_RS09110	COG4191	Histidine kinase
LH365_RS09130	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LH365_RS09135	COG1530	ribonuclease E activity
LH365_RS09140	COG0424	maF-like protein
LH365_RS09145	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LH365_RS09155	COG5328	Belongs to the UPF0262 family
LH365_RS09200	COG0393	Putative heavy-metal-binding
LH365_RS09215	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LH365_RS09225	COG0460	homoserine dehydrogenase
LH365_RS09235	COG4221	oxidoreductase activity
LH365_RS09250	COG0626	cystathionine gamma-synthase activity
LH365_RS09255	COG1595	DNA-templated transcription, initiation
LH365_RS09260	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LH365_RS09270	COG0667	Aldo Keto reductase
LH365_RS09275	COG1764	response to oxidative stress
LH365_RS09280	COG1846	Transcriptional regulator
LH365_RS09330	COG1496	oxidoreductase activity
LH365_RS09345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LH365_RS09350	COG0193	aminoacyl-tRNA hydrolase activity
LH365_RS09355	COG1819	glycosyl
LH365_RS09365	COG0012	GTP binding
LH365_RS09375	COG1418	mRNA catabolic process
LH365_RS09380	COG2857	Cytochrome c1
LH365_RS09380	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LH365_RS09385	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LH365_RS09385	COG2857	Cytochrome c1
LH365_RS09390	COG0723	plastoquinol--plastocyanin reductase activity
LH365_RS09395	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LH365_RS09400	COG0408	coproporphyrinogen oxidase activity
LH365_RS09410	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LH365_RS09410	COG0519	Catalyzes the synthesis of GMP from XMP
LH365_RS09425	COG3153	acetyltransferase
LH365_RS09430	COG1024	Enoyl-CoA hydratase
LH365_RS09440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LH365_RS09450	COG0354	folic acid binding
LH365_RS09480	COG1194	a g-specific adenine glycosylase
LH365_RS09490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LH365_RS09500	COG1802	Transcriptional regulator
LH365_RS09515	COG0356	it plays a direct role in the translocation of protons across the membrane
LH365_RS09525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LH365_RS09530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LH365_RS09540	COG2239	Acts as a magnesium transporter
LH365_RS09565	COG0321	lipoyl(octanoyl) transferase activity
LH365_RS09570	COG3152	Membrane
LH365_RS09585	COG0564	pseudouridine synthase activity
LH365_RS09600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LH365_RS09620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH365_RS09625	COG1278	Cold shock
LH365_RS09635	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LH365_RS09650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LH365_RS09655	COG0142	geranyltranstransferase activity
LH365_RS09670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LH365_RS09685	COG1595	DNA-templated transcription, initiation
LH365_RS09700	COG1501	Belongs to the glycosyl hydrolase 31 family
LH365_RS09710	COG2186	Transcriptional regulator
LH365_RS09720	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LH365_RS09725	COG1684	flagellar biosynthetic protein fliR
LH365_RS09730	COG1987	bacterial-type flagellum assembly
LH365_RS09735	COG1677	Flagellar hook-basal body complex protein FliE
LH365_RS09740	COG1558	bacterial-type flagellum-dependent cell motility
LH365_RS09750	COG3190	flagellar
LH365_RS09755	COG1338	Plays a role in the flagellum-specific transport system
LH365_RS09765	COG3609	addiction module antidote protein, CC2985 family
LH365_RS09815	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LH365_RS09825	COG0405	Gamma-glutamyltransferase
LH365_RS09840	COG0772	Belongs to the SEDS family
LH365_RS09845	COG0768	penicillin binding
LH365_RS09870	COG0436	Aminotransferase
LH365_RS09875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LH365_RS09890	COG0783	Belongs to the Dps family
LH365_RS09900	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LH365_RS09915	COG1566	PFAM secretion protein HlyD family protein
LH365_RS09920	COG1136	(ABC) transporter
LH365_RS09930	COG4786	Flagellar basal body rod
LH365_RS09935	COG4786	Flagellar basal body rod
LH365_RS09940	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
LH365_RS09945	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LH365_RS09955	COG0167	dihydroorotate dehydrogenase activity
LH365_RS09970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH365_RS09990	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
LH365_RS10005	COG0463	Glycosyl transferase, family 2
LH365_RS10035	COG0114	fumarate hydratase activity
LH365_RS10050	COG1132	(ABC) transporter
LH365_RS10060	COG3842	ATPase activity
LH365_RS10080	COG0174	glutamine synthetase
LH365_RS10085	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LH365_RS10090	COG1012	belongs to the aldehyde dehydrogenase family
LH365_RS10095	COG1012	belongs to the aldehyde dehydrogenase family
LH365_RS10105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LH365_RS10125	COG1230	cation diffusion facilitator family transporter
LH365_RS10155	COG0217	transcriptional regulatory protein
LH365_RS10160	COG1692	metallophosphoesterase
LH365_RS10170	COG0861	Integral membrane protein TerC family
LH365_RS10205	COG1278	Cold shock
LH365_RS10210	COG2813	Specifically methylates the guanine in position
LH365_RS10215	COG1187	pseudouridine synthase activity
LH365_RS10230	COG0642	Histidine kinase
LH365_RS10255	COG0071	Belongs to the small heat shock protein (HSP20) family
LH365_RS10260	COG2378	regulation of single-species biofilm formation
LH365_RS10265	COG0626	cystathionine gamma-synthase activity
LH365_RS10270	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LH365_RS10280	COG4208	sulfate ABC transporter
LH365_RS10285	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LH365_RS10300	COG4206	TonB-dependent receptor
LH365_RS10305	COG0006	proline dipeptidase activity
LH365_RS10315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LH365_RS10320	COG0497	DNA recombination
LH365_RS10325	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH365_RS10330	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LH365_RS10340	COG0849	cell division
LH365_RS10360	COG0037	tRNA processing
LH365_RS10375	COG2885	chlorophyll binding
LH365_RS10380	COG0823	Involved in the tonB-independent uptake of proteins
LH365_RS10405	COG2255	four-way junction helicase activity
LH365_RS10410	COG0632	four-way junction helicase activity
LH365_RS10415	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LH365_RS10465	COG0640	Transcriptional regulator
LH365_RS10475	COG3300	MHYT domain
LH365_RS10475	COG5001	Diguanylate cyclase
LH365_RS10485	COG2706	6-phosphogluconolactonase activity
LH365_RS10490	COG2188	Transcriptional regulator
LH365_RS10505	COG0738	Major facilitator superfamily
LH365_RS10510	COG2971	BadF BadG BcrA BcrD
LH365_RS10515	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LH365_RS10520	COG2885	chlorophyll binding
LH365_RS10565	COG0024	Methionine aminopeptidase
LH365_RS10590	COG1063	alcohol dehydrogenase
LH365_RS10605	COG0352	thiamine-phosphate diphosphorylase activity
LH365_RS10610	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_RS10620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LH365_RS10625	COG0483	inositol monophosphate 1-phosphatase activity
LH365_RS10630	COG1309	transcriptional regulator
LH365_RS10640	COG1132	(ABC) transporter
LH365_RS10650	COG0387	Pfam Sodium calcium exchanger
LH365_RS10680	COG2171	N-acyltransferase activity
LH365_RS10690	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
LH365_RS10695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LH365_RS10700	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LH365_RS10705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LH365_RS10720	COG3077	Addiction module antitoxin, RelB DinJ family
LH365_RS10725	COG0489	protein tyrosine kinase activity
LH365_RS10730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LH365_RS10740	COG0129	dihydroxy-acid dehydratase activity
LH365_RS10765	COG1012	belongs to the aldehyde dehydrogenase family
LH365_RS10805	COG0210	DNA helicase
LH365_RS10825	COG0657	acetylesterase activity
LH365_RS10825	COG2755	lipolytic protein G-D-S-L family
LH365_RS10840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LH365_RS10860	COG0215	cysteine-tRNA ligase activity
LH365_RS10865	COG0302	gtp cyclohydrolase
LH365_RS10870	COG0848	biopolymer transport protein
LH365_RS10875	COG0564	pseudouridine synthase activity
LH365_RS10885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH365_RS10905	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LH365_RS10910	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LH365_RS10920	COG0351	phosphomethylpyrimidine kinase
LH365_RS10920	COG0352	thiamine-phosphate diphosphorylase activity
LH365_RS10945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LH365_RS10950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LH365_RS10990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LH365_RS11010	COG0072	phenylalanine-tRNA ligase activity
LH365_RS11010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH365_RS11030	COG0640	Transcriptional regulator
LH365_RS11055	COG0706	membrane insertase activity
LH365_RS11080	COG0494	nUDIX hydrolase
LH365_RS11100	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LH365_RS11125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LH365_RS11130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LH365_RS11235	COG3023	N-Acetylmuramoyl-L-alanine amidase
LH365_RS11265	COG0006	proline dipeptidase activity
LH365_RS11295	COG1181	Belongs to the D-alanine--D-alanine ligase family
LH365_RS11315	COG1410	methionine synthase
LH365_RS11315	COG0646	methionine synthase
LH365_RS11325	COG2226	methyltransferase
LH365_RS11335	COG3422	double-strand break repair
LH365_RS11345	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LH365_RS11380	COG1609	Transcriptional regulator
LH365_RS11385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LH365_RS11405	COG0587	DNA-directed DNA polymerase activity
LH365_RS11410	COG1309	transcriptional regulator
LH365_RS11415	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_RS11420	COG0251	oxidation-reduction process
LH365_RS11425	COG1309	transcriptional regulator
LH365_RS11465	COG2222	sugar isomerase
LH365_RS11490	COG3345	alpha-galactosidase
LH365_RS11495	COG1349	DNA-binding transcription factor activity
LH365_RS11545	COG2814	Major facilitator Superfamily
LH365_RS11550	COG2186	Transcriptional regulator
LH365_RS11555	COG4948	Mandelate Racemase Muconate Lactonizing
LH365_RS11560	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_RS11570	COG0745	RESPONSE REGULATOR receiver
LH365_RS11575	COG4251	negative regulation of phosphorylation
LH365_RS11580	COG5002	protein histidine kinase activity
LH365_RS11585	COG0745	RESPONSE REGULATOR receiver
LH365_RS11595	COG2201	protein-glutamate methylesterase activity
LH365_RS11600	COG1959	2 iron, 2 sulfur cluster binding
LH365_RS11640	COG2308	Evidence 4 Homologs of previously reported genes of
LH365_RS11670	COG1940	carbohydrate kinase activity
LH365_RS11695	COG0469	pyruvate kinase activity
LH365_RS11700	COG0295	cytidine deaminase activity
LH365_RS11710	COG0738	Major facilitator superfamily
LH365_RS11720	COG1414	Transcriptional regulator
LH365_RS11735	COG2721	sulfolactate sulfo-lyase activity
LH365_RS11740	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_RS11755	COG2814	Major facilitator Superfamily
LH365_RS11755	COG0477	Major facilitator Superfamily
LH365_RS11760	COG0129	dihydroxy-acid dehydratase activity
LH365_RS11765	COG3386	PFAM SMP-30 Gluconolaconase
LH365_RS11810	COG1278	Cold shock
LH365_RS11815	COG0505	Belongs to the CarA family
LH365_RS11835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LH365_RS11855	COG1505	serine-type exopeptidase activity
LH365_RS11865	COG1414	Transcriptional regulator
LH365_RS11870	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LH365_RS11885	COG3250	beta-galactosidase activity
LH365_RS11905	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_RS11930	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LH365_RS11940	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LH365_RS11940	COG1918	ferrous iron import across plasma membrane
LH365_RS11960	COG2252	PERMEase
LH365_RS11995	COG1472	Belongs to the glycosyl hydrolase 3 family
LH365_RS12000	COG1609	Transcriptional regulator
LH365_RS12005	COG0800	Aldolase
LH365_RS12010	COG0837	glucose binding
LH365_RS12015	COG0129	dihydroxy-acid dehydratase activity
LH365_RS12020	COG0363	glucosamine-6-phosphate deaminase activity
LH365_RS12025	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LH365_RS12030	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LH365_RS12045	COG0308	aminopeptidase N
LH365_RS12055	COG2202	Pas domain
LH365_RS12055	COG2205	protein histidine kinase activity
LH365_RS12065	COG0300	oxidoreductase activity
LH365_RS12070	COG0697	spore germination
LH365_RS12085	COG1595	DNA-templated transcription, initiation
LH365_RS12090	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LH365_RS12100	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_RS12110	COG2205	protein histidine kinase activity
LH365_RS12125	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_RS12130	COG5265	(ABC) transporter
LH365_RS12140	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LH365_RS12145	COG2819	hydrolase of the alpha beta superfamily
LH365_RS12150	COG1082	Xylose isomerase domain protein TIM barrel
LH365_RS12155	COG1609	Transcriptional regulator
LH365_RS12165	COG1760	l-serine dehydratase
LH365_RS12200	COG1609	Transcriptional regulator
LH365_RS12220	COG5487	UPF0391 membrane protein
LH365_RS12225	COG2267	carboxylic ester hydrolase activity
LH365_RS12230	COG1846	Transcriptional regulator
LH365_RS12240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LH365_RS12245	COG2205	protein histidine kinase activity
LH365_RS12255	COG2205	protein histidine kinase activity
LH365_RS12255	COG0784	Response regulator, receiver
LH365_RS12265	COG5002	protein histidine kinase activity
LH365_RS12295	COG2186	Transcriptional regulator
LH365_RS12300	COG1301	dicarboxylic acid transport
LH365_RS12315	COG2346	COG2346, Truncated hemoglobins
LH365_RS12325	COG3088	subunit of a heme lyase
LH365_RS12330	COG1138	Cytochrome C-type biogenesis protein
LH365_RS12365	COG0484	heat shock protein binding
LH365_RS12455	COG2983	Belongs to the UPF0260 family
LH365_RS12460	COG0488	(ABC) transporter
LH365_RS12475	COG2982	Protein involved in outer membrane biogenesis
LH365_RS12480	COG0339	signal peptide processing
LH365_RS12490	COG0583	DNA-binding transcription factor activity
LH365_RS12495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LH365_RS12500	COG1024	Enoyl-CoA hydratase
LH365_RS12505	COG0439	Biotin carboxylase
LH365_RS12510	COG1960	acyl-CoA dehydrogenase activity
LH365_RS12525	COG1024	Enoyl-CoA hydratase
LH365_RS12540	COG1522	sequence-specific DNA binding
LH365_RS12555	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH365_RS12560	COG1960	acyl-CoA dehydrogenase activity
LH365_RS12565	COG1012	belongs to the aldehyde dehydrogenase family
LH365_RS12570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH365_RS12620	COG1609	Transcriptional regulator
LH365_RS12640	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LH365_RS12650	COG3550	peptidyl-serine autophosphorylation
LH365_RS12685	COG3727	T/G mismatch-specific endonuclease activity
LH365_RS12720	COG0582	viral genome integration into host DNA
LH365_RS12755	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LH365_RS12765	COG0166	Belongs to the GPI family
LH365_RS12770	COG1012	belongs to the aldehyde dehydrogenase family
LH365_RS12785	COG0004	ammonium transporteR
LH365_RS12820	COG3609	addiction module antidote protein, CC2985 family
LH365_RS12830	COG1083	cytidylyl-transferase
LH365_RS12835	COG1648	precorrin-2 dehydrogenase activity
LH365_RS12835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LH365_RS12845	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LH365_RS12855	COG0175	sulfate reduction
LH365_RS12895	COG0513	Belongs to the DEAD box helicase family
LH365_RS12900	COG0308	aminopeptidase N
LH365_RS12905	COG0745	RESPONSE REGULATOR receiver
LH365_RS12920	COG3971	2-oxopent-4-enoate hydratase activity
LH365_RS12925	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
LH365_RS12940	COG0395	ABC-type sugar transport system, permease component
LH365_RS12945	COG1175	transmembrane transport
LH365_RS12950	COG3842	ATPase activity
LH365_RS12965	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_RS12975	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_RS12980	COG1414	Transcriptional regulator
LH365_RS12985	COG4948	Mandelate Racemase Muconate Lactonizing
LH365_RS12995	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_RS13035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH365_RS13055	COG2755	lipolytic protein G-D-S-L family
LH365_RS13080	COG4952	isomerase
LH365_RS13100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LH365_RS13120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH365_RS13135	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LH365_RS13140	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LH365_RS13145	COG3932	Exopolysaccharide synthesis, ExoD
LH365_RS13165	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LH365_RS13170	COG1091	dTDP-4-dehydrorhamnose reductase activity
LH365_RS13175	COG1088	dTDP-glucose 4,6-dehydratase activity
LH365_RS13180	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
LH365_RS13185	COG0339	signal peptide processing
LH365_RS13190	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LH365_RS13205	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LH365_RS13255	COG1215	transferase activity, transferring glycosyl groups
LH365_RS13260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LH365_RS13295	COG0438	transferase activity, transferring glycosyl groups
LH365_RS13295	COG1216	Glycosyl transferase, family 2
LH365_RS13300	COG0463	Glycosyl transferase, family 2
LH365_RS13305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH365_RS13315	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LH365_RS13320	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LH365_RS13330	COG0175	sulfate reduction
LH365_RS13335	COG1218	3'(2'),5'-bisphosphate nucleotidase
LH365_RS13340	COG2942	2-epimerase
LH365_RS13360	COG1435	thymidine kinase activity
LH365_RS13365	COG2816	NAD+ diphosphatase activity
LH365_RS13375	COG0288	reversible hydration of carbon dioxide
LH365_RS13385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LH365_RS13400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LH365_RS13415	COG2835	tetraacyldisaccharide 4'-kinase activity
LH365_RS13425	COG0477	Major facilitator Superfamily
LH365_RS13430	COG0745	RESPONSE REGULATOR receiver
LH365_RS13440	COG5002	protein histidine kinase activity
LH365_RS13445	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LH365_RS13480	COG0492	ferredoxin-NADP+ reductase activity
LH365_RS13485	COG0583	DNA-binding transcription factor activity
LH365_RS13495	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LH365_RS13505	COG0358	DNA primase activity
LH365_RS13510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LH365_RS13515	COG0285	dihydrofolate synthase activity
LH365_RS13530	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LH365_RS13535	COG0539	negative regulation of cytoplasmic translation
LH365_RS13555	COG0135	phosphoribosylanthranilate isomerase activity
LH365_RS13560	COG0133	tryptophan synthase activity
LH365_RS13565	COG0159	tryptophan synthase activity
LH365_RS13590	COG0667	Aldo Keto reductase
LH365_RS13605	COG2814	Major facilitator Superfamily
LH365_RS13610	COG0514	ATP-dependent DNA helicase (RecQ)
LH365_RS13615	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LH365_RS13625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LH365_RS13630	COG0268	Binds directly to 16S ribosomal RNA
LH365_RS13645	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LH365_RS13650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LH365_RS13680	COG0823	Involved in the tonB-independent uptake of proteins
LH365_RS13680	COG1506	peptidase
LH365_RS13700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH365_RS13705	COG0577	efflux transmembrane transporter activity
LH365_RS13705	COG1136	(ABC) transporter
LH365_RS13720	COG2132	Multicopper oxidase
LH365_RS13735	COG1609	Transcriptional regulator
LH365_RS13740	COG0477	Major facilitator Superfamily
LH365_RS13765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LH365_RS13790	COG0754	glutathionylspermidine amidase activity
LH365_RS13825	COG0805	protein transport
LH365_RS13830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LH365_RS13835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LH365_RS13840	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LH365_RS13845	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LH365_RS13850	COG1472	Belongs to the glycosyl hydrolase 3 family
LH365_RS13860	COG1671	Belongs to the UPF0178 family
LH365_RS13875	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LH365_RS13890	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LH365_RS13905	COG2271	Major facilitator Superfamily
LH365_RS13925	COG2186	Transcriptional regulator
LH365_RS13935	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LH365_RS13945	COG0583	DNA-binding transcription factor activity
LH365_RS13970	COG3685	Protein conserved in bacteria
LH365_RS13975	COG1914	H( )-stimulated, divalent metal cation uptake system
LH365_RS14005	COG1793	dna ligase
LH365_RS14010	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LH365_RS14010	COG1793	dna ligase
LH365_RS14015	COG1201	RNA secondary structure unwinding
LH365_RS14030	COG1472	Belongs to the glycosyl hydrolase 3 family
LH365_RS14035	COG3534	alpha-L-arabinofuranosidase
LH365_RS14065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LH365_RS14090	COG1742	UPF0060 membrane protein
LH365_RS14095	COG0534	Mate efflux family protein
LH365_RS14105	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LH365_RS14120	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LH365_RS14130	COG0546	phosphoglycolate phosphatase activity
LH365_RS14225	COG0475	glutathione-regulated potassium exporter activity
LH365_RS14225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LH365_RS14235	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LH365_RS14265	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LH365_RS14285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LH365_RS14290	COG0745	RESPONSE REGULATOR receiver
LH365_RS14320	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LH365_RS14330	COG2264	protein methyltransferase activity
LH365_RS14345	COG0612	Peptidase, M16
LH365_RS14350	COG1396	sequence-specific DNA binding
LH365_RS14355	COG0483	inositol monophosphate 1-phosphatase activity
LH365_RS14385	COG1472	Belongs to the glycosyl hydrolase 3 family
LH365_RS14390	COG3047	cAMP biosynthetic process
LH365_RS14400	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LH365_RS14415	COG0322	excinuclease ABC activity
LH365_RS14435	COG0142	geranyltranstransferase activity
LH365_RS14440	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LH365_RS14450	COG0542	response to heat
LH365_RS14470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LH365_RS14475	COG0438	transferase activity, transferring glycosyl groups
LH365_RS14525	COG1285	pathogenesis
LH365_RS14560	COG1846	Transcriptional regulator
LH365_RS14560	COG1940	carbohydrate kinase activity
LH365_RS14580	COG4771	TonB-dependent receptor
LH365_RS14590	COG1595	DNA-templated transcription, initiation
LH365_RS14595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH365_RS14615	COG0583	DNA-binding transcription factor activity
LH365_RS14645	COG1446	asparaginase
LH365_RS14655	COG4206	TonB-dependent receptor
LH365_RS14695	COG0784	Response regulator, receiver
LH365_RS14700	COG4251	negative regulation of phosphorylation
LH365_RS14720	COG0475	glutathione-regulated potassium exporter activity
LH365_RS14745	COG2011	ABC-type metal ion transport system permease component
LH365_RS14750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LH365_RS14770	COG4771	TonB-dependent receptor
LH365_RS14775	COG3250	beta-galactosidase activity
LH365_RS14780	COG4948	Mandelate Racemase Muconate Lactonizing
LH365_RS14785	COG3661	Belongs to the glycosyl hydrolase 67 family
LH365_RS14800	COG1278	Cold shock
LH365_RS14815	COG2211	Major facilitator Superfamily
LH365_RS14820	COG1609	Transcriptional regulator
LH365_RS14840	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LH365_RS14880	COG2866	Carboxypeptidase
LH365_RS14915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LH365_RS14935	COG1609	Transcriptional regulator
LH365_RS14940	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_RS14945	COG1304	FMN binding
LH365_RS14955	COG0697	spore germination
LH365_RS14960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH365_RS14970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LH365_RS14975	COG0581	inorganic phosphate transmembrane transporter activity
LH365_RS14980	COG0573	inorganic phosphate transmembrane transporter activity
LH365_RS14985	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LH365_RS14995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH365_RS15000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH365_RS15045	COG4957	zinc ion binding
LH365_RS15070	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LH365_RS15095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH365_RS15100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH365_RS15135	COG3250	beta-galactosidase activity
LH365_RS15185	COG4206	TonB-dependent receptor
LH365_RS15195	COG0531	amino acid
LH365_RS15200	COG2204	response regulator
LH365_RS15205	COG4191	Histidine kinase
LH365_RS15210	COG1301	dicarboxylic acid transport
LH365_RS15220	COG3852	Histidine kinase
LH365_RS15225	COG2204	response regulator
LH365_RS15235	COG1136	(ABC) transporter
LH365_RS15240	COG0577	efflux transmembrane transporter activity
LH365_RS15245	COG2271	Major facilitator Superfamily
LH365_RS15250	COG0596	Alpha beta hydrolase
LH365_RS15250	COG2945	thiolester hydrolase activity
LH365_RS15260	COG3507	Belongs to the glycosyl hydrolase 43 family
LH365_RS15280	COG1063	alcohol dehydrogenase
LH365_RS15330	COG0583	DNA-binding transcription factor activity
LH365_RS15340	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_RS15390	COG0438	transferase activity, transferring glycosyl groups
LH365_RS15395	COG0366	Alpha amylase catalytic
LH365_RS15400	COG0596	Alpha beta hydrolase
LH365_RS15410	COG5002	protein histidine kinase activity
LH365_RS15440	COG0438	transferase activity, transferring glycosyl groups
LH365_RS15450	COG0366	Alpha amylase catalytic
LH365_RS15530	COG0667	Aldo Keto reductase
LH365_RS15535	COG2207	Transcriptional regulator
LH365_RS15605	COG0464	growth
LH365_RS15625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LH365_RS15695	COG4962	Type ii secretion system protein e
LH365_RS15710	COG3451	type IV secretory pathway VirB4
LH365_RS15720	COG3846	protein secretion by the type IV secretion system
LH365_RS15730	COG3504	Conjugal transfer protein
LH365_RS15735	COG2948	multi-organism process
LH365_RS15755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LH365_RS15760	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LH365_RS15760	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LH365_RS15765	COG2771	luxR family
LH365_RS15780	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LH365_RS15810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LH365_RS15820	COG2119	membrane
LH365_RS15840	COG2755	lipolytic protein G-D-S-L family
LH365_RS15845	COG2755	lipolytic protein G-D-S-L family
LH365_RS15850	COG0538	isocitrate dehydrogenase activity
LH365_RS15860	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LH365_RS15915	COG0823	Involved in the tonB-independent uptake of proteins
LH365_RS15915	COG1506	peptidase
LH365_RS15915	COG4946	Tricorn protease homolog
LH365_RS15920	COG4206	TonB-dependent receptor
LH365_RS15935	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LH365_RS15940	COG3254	rhamnose metabolic process
LH365_RS15945	COG1448	Aminotransferase
LH365_RS15960	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LH365_RS15975	COG2271	Major facilitator Superfamily
LH365_RS16020	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LH365_RS16050	COG0714	Associated with various cellular activities
LH365_RS16075	COG5002	protein histidine kinase activity
LH365_RS16075	COG5001	Diguanylate cyclase
LH365_RS16085	COG3300	MHYT domain
LH365_RS16085	COG5001	Diguanylate cyclase
LH365_RS16090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH365_RS16110	COG3387	PFAM Glycoside hydrolase 15-related
LH365_RS16115	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LH365_RS16120	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LH365_RS16155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LH365_RS16175	COG2072	flavoprotein involved in K transport
LH365_RS16180	COG2351	hydroxyisourate hydrolase activity
LH365_RS16185	COG2080	2 iron, 2 sulfur cluster binding
LH365_RS16190	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LH365_RS16200	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LH365_RS16205	COG0402	S-adenosylhomocysteine deaminase activity
LH365_RS16215	COG0316	Belongs to the HesB IscA family
LH365_RS16225	COG0346	lactoylglutathione lyase activity
LH365_RS16235	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LH365_RS16240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LH365_RS16250	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LH365_RS16255	COG1607	acyl-coa hydrolase
LH365_RS16285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH365_RS16295	COG0154	amidase activity
LH365_RS16310	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LH365_RS16320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH365_RS16320	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LH365_RS16350	COG2197	response regulator
LH365_RS16390	COG0673	inositol 2-dehydrogenase activity
LH365_RS16455	COG2205	protein histidine kinase activity
LH365_RS16475	COG4591	ABC-type transport system involved in lipoprotein release permease component
LH365_RS16475	COG1136	(ABC) transporter
LH365_RS16545	COG2264	protein methyltransferase activity
LH365_RS16550	COG4771	TonB-dependent receptor
LH365_RS16555	COG0583	DNA-binding transcription factor activity
LH365_RS16565	COG2271	Major facilitator Superfamily
LH365_RS16570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH365_RS16575	COG1609	Transcriptional regulator
LH365_RS16605	COG2211	Major facilitator Superfamily
LH365_RS16630	COG5002	protein histidine kinase activity
LH365_RS16630	COG2205	protein histidine kinase activity
LH365_RS16630	COG0784	Response regulator, receiver
LH365_RS16645	COG3250	beta-galactosidase activity
LH365_RS16655	COG3250	beta-galactosidase activity
LH365_RS16675	COG3867	Arabinogalactan endo-beta-1,4-galactanase
LH365_RS16720	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LH365_RS16730	COG0297	glycogen (starch) synthase activity
LH365_RS16735	COG0438	transferase activity, transferring glycosyl groups
LH365_RS16740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH365_RS16750	COG1045	serine acetyltransferase
LH365_RS16760	COG0438	transferase activity, transferring glycosyl groups
LH365_RS16785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH365_RS16800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LH365_RS16805	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH365_RS16815	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH365_RS16860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LH365_RS16870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LH365_RS16875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH365_RS16880	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LH365_RS16885	COG1522	sequence-specific DNA binding
LH365_RS16895	COG2259	Doxx family
LH365_RS16915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH365_RS16965	COG1702	phosphate starvation-inducible protein PhoH
LH365_RS16985	COG1309	transcriptional regulator
LH365_RS17000	COG0673	inositol 2-dehydrogenase activity
LH365_RS17025	COG0069	glutamate synthase activity
LH365_RS17045	COG1217	gtp-binding protein TYPA
LH365_RS17075	COG4251	negative regulation of phosphorylation
LH365_RS17080	COG4251	negative regulation of phosphorylation
LH365_RS17100	COG4774	siderophore transport
LH365_RS17105	COG3128	pkhd-type hydroxylase
LH365_RS17125	COG1477	protein flavinylation
LH365_RS17130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LH365_RS17140	COG3046	protein related to deoxyribodipyrimidine photolyase
LH365_RS17155	COG4771	TonB-dependent receptor
LH365_RS17160	COG0457	Tetratricopeptide repeat
LH365_RS17180	COG2755	lipolytic protein G-D-S-L family
LH365_RS17180	COG0657	acetylesterase activity
LH365_RS17185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH365_RS17215	COG3459	Glycosyltransferase 36 associated
LH365_RS17220	COG3682	Transcriptional regulator
LH365_RS17240	COG5002	protein histidine kinase activity
LH365_RS17240	COG2205	protein histidine kinase activity
LH365_RS17240	COG0784	Response regulator, receiver
LH365_RS17300	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LH365_RS17310	COG0392	lysyltransferase activity
LH365_RS17310	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LH365_RS17330	COG1546	Belongs to the CinA family
LH365_RS17330	COG1058	Belongs to the CinA family
LH365_RS17345	COG4941	Belongs to the sigma-70 factor family
LH365_RS17365	COG0583	DNA-binding transcription factor activity
LH365_RS17450	COG1309	transcriptional regulator
LH365_RS17480	COG0784	Response regulator, receiver
LH365_RS17480	COG2198	Histidine kinase
LH365_RS17480	COG2205	protein histidine kinase activity
LH365_RS17490	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LH365_RS17495	COG1335	isochorismatase
LH365_RS17505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LH365_RS17510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH365_RS17515	COG0277	FAD linked oxidase domain protein
LH365_RS17525	COG2824	Alkylphosphonate utilization operon protein PhnA
LH365_RS17545	COG0753	catalase activity
LH365_RS17555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LH365_RS17580	COG0596	Alpha beta hydrolase
LH365_RS17595	COG1309	transcriptional regulator
LH365_RS17605	COG1131	(ABC) transporter
LH365_RS17610	COG0842	Transport permease protein
LH365_RS17620	COG4771	TonB-dependent receptor
LH365_RS17630	COG1506	peptidase
LH365_RS17630	COG4946	Tricorn protease homolog
LH365_RS17630	COG0823	Involved in the tonB-independent uptake of proteins
LH365_RS17705	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
LH365_RS17760	COG1846	Transcriptional regulator
LH365_RS17780	COG0667	Aldo Keto reductase
LH365_RS17785	COG1473	amidohydrolase
LH365_RS17800	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
LH365_RS17820	COG3451	type IV secretory pathway VirB4
LH365_RS17835	COG0741	lytic transglycosylase activity
LH365_RS17885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LH365_RS17885	COG0475	glutathione-regulated potassium exporter activity
LH365_RS17890	COG2971	BadF BadG BcrA BcrD
LH365_RS17910	COG2186	Transcriptional regulator
LH365_RS17915	COG2188	Transcriptional regulator
LH365_RS17990	COG2271	Major facilitator Superfamily
LH365_RS18005	COG1609	Transcriptional regulator
LH365_RS18015	COG5001	Diguanylate cyclase
LH365_RS18020	COG3300	MHYT domain
LH365_RS18020	COG5001	Diguanylate cyclase
LH365_RS18045	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LH365_RS18050	COG5634	Uncharacterized conserved protein (DUF2278)
LH365_RS18095	COG3275	phosphorelay sensor kinase activity
LH365_RS18100	COG3279	Response regulator of the LytR AlgR family
LH365_RS18120	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LH365_RS18125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LH365_RS18130	COG1845	cytochrome c oxidase, subunit III
LH365_RS18135	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LH365_RS18140	COG3177	Filamentation induced by cAMP protein fic
LH365_RS18145	COG3940	Belongs to the glycosyl hydrolase 43 family
LH365_RS18165	COG1192	Involved in chromosome partitioning
LH365_RS18215	COG0179	Fumarylacetoacetate (FAA) hydrolase
LH365_RS18220	COG1414	Transcriptional regulator
LH365_RS18235	COG2271	Major facilitator Superfamily
LH365_RS18240	COG3250	beta-galactosidase activity
LH365_RS18265	COG1472	Belongs to the glycosyl hydrolase 3 family
LH365_RS18270	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
LH365_RS18330	COG3012	SEC-C Motif Domain Protein
LH365_RS18370	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
LH365_RS18405	COG0446	pyridine nucleotide-disulphide oxidoreductase
LH365_RS18410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LH365_RS18425	COG0640	Transcriptional regulator
LH365_RS18515	COG1309	transcriptional regulator
LH365_RS18525	COG3422	double-strand break repair
LH365_RS18580	COG2948	multi-organism process
LH365_RS18640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH365_RS18660	COG0366	Alpha amylase catalytic