locus-tag	class	description
I6G45_RS00005	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G45_RS00015	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
I6G45_RS00020	COG0626	cystathionine gamma-synthase activity
I6G45_RS00025	COG0527	aspartate kinase activity
I6G45_RS00025	COG0460	homoserine dehydrogenase
I6G45_RS00030	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6G45_RS00035	COG0371	Dehydrogenase
I6G45_RS00040	COG2194	sulfuric ester hydrolase activity
I6G45_RS00055	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6G45_RS00075	COG0583	DNA-binding transcription factor activity
I6G45_RS00150	COG3085	chromosome segregation
I6G45_RS00155	COG0606	chelatase, subunit chli
I6G45_RS00170	COG3978	acetolactate synthase activity
I6G45_RS00185	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G45_RS00210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G45_RS00235	COG3118	belongs to the thioredoxin family
I6G45_RS00240	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6G45_RS00245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G45_RS00260	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6G45_RS00265	COG1088	dTDP-glucose 4,6-dehydratase activity
I6G45_RS00270	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6G45_RS00275	COG0456	acetyltransferase
I6G45_RS00280	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G45_RS00285	COG2244	polysaccharide biosynthetic process
I6G45_RS00290	COG1819	glycosyl
I6G45_RS00330	COG3071	HemY protein
I6G45_RS00335	COG2959	enzyme of heme biosynthesis
I6G45_RS00340	COG1587	Uroporphyrinogen-III synthase
I6G45_RS00360	COG5567	small periplasmic lipoprotein
I6G45_RS00380	COG1011	Hydrolase
I6G45_RS00390	COG0598	Magnesium transport protein CorA
I6G45_RS00405	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6G45_RS00415	COG1280	lysine exporter protein (LysE YggA)
I6G45_RS00420	COG1280	lysine exporter protein (LysE YggA)
I6G45_RS00425	COG2267	carboxylic ester hydrolase activity
I6G45_RS00430	COG0561	phosphatase activity
I6G45_RS00440	COG0583	DNA-binding transcription factor activity
I6G45_RS00450	COG0412	Dienelactone hydrolase
I6G45_RS00460	COG1322	Protein conserved in bacteria
I6G45_RS00465	COG2226	methyltransferase
I6G45_RS00475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6G45_RS00485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G45_RS00490	COG0805	protein transport
I6G45_RS00500	COG0250	Participates in transcription elongation, termination and antitermination
I6G45_RS00520	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G45_RS00520	COG1024	Enoyl-CoA hydratase
I6G45_RS00530	COG1739	Uncharacterized protein family UPF0029
I6G45_RS00615	COG0250	Participates in transcription elongation, termination and antitermination
I6G45_RS00630	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6G45_RS00660	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6G45_RS00670	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6G45_RS00680	COG2104	thiamine diphosphate biosynthetic process
I6G45_RS00685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G45_RS00700	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6G45_RS00715	COG1515	deoxyribonuclease V activity
I6G45_RS00735	COG0151	Belongs to the GarS family
I6G45_RS00770	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6G45_RS00795	COG1410	methionine synthase
I6G45_RS00795	COG0646	methionine synthase
I6G45_RS00800	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6G45_RS00815	COG1187	pseudouridine synthase activity
I6G45_RS00830	COG0527	aspartate kinase activity
I6G45_RS00855	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G45_RS00865	COG3833	ABC-type maltose transport systems, permease component
I6G45_RS00875	COG2182	Extracellular solute-binding protein
I6G45_RS00910	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6G45_RS00915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G45_RS00920	COG0534	Mate efflux family protein
I6G45_RS00930	COG0735	belongs to the Fur family
I6G45_RS00940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G45_RS00960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G45_RS00965	COG3201	nicotinamide mononucleotide transporter
I6G45_RS00975	COG1448	Aminotransferase
I6G45_RS00980	COG0432	Pfam Uncharacterised protein family UPF0047
I6G45_RS00985	COG2315	Protein conserved in bacteria
I6G45_RS00990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G45_RS01025	COG3706	GGDEF domain
I6G45_RS01030	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6G45_RS01040	COG0789	Transcriptional regulator
I6G45_RS01045	COG0625	glutathione transferase activity
I6G45_RS01050	COG2252	PERMEase
I6G45_RS01055	COG0025	NhaP-type Na H and K H
I6G45_RS01060	COG0583	DNA-binding transcription factor activity
I6G45_RS01070	COG3162	membrane
I6G45_RS01080	COG1301	dicarboxylic acid transport
I6G45_RS01105	COG0191	fructose-bisphosphate aldolase activity
I6G45_RS01120	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G45_RS01125	COG1129	ABC transporter
I6G45_RS01130	COG4191	Histidine kinase
I6G45_RS01130	COG0784	Response regulator, receiver
I6G45_RS01140	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6G45_RS01145	COG2188	Transcriptional regulator
I6G45_RS01155	COG2824	Alkylphosphonate utilization operon protein PhnA
I6G45_RS01160	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6G45_RS01295	COG1309	transcriptional regulator
I6G45_RS01310	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6G45_RS01320	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6G45_RS01350	COG1509	lysine 2,3-aminomutase activity
I6G45_RS01360	COG5510	response to toxic substance
I6G45_RS01365	COG5510	response to toxic substance
I6G45_RS01380	COG3040	lipid binding
I6G45_RS01385	COG0641	radical SAM
I6G45_RS01390	COG1263	PTS System
I6G45_RS01390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G45_RS01390	COG2190	(PTS) system
I6G45_RS01405	COG1737	Transcriptional regulator
I6G45_RS01410	COG2149	membrane
I6G45_RS01430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G45_RS01435	COG1053	succinate dehydrogenase
I6G45_RS01445	COG3264	Mechanosensitive ion channel
I6G45_RS01445	COG1511	domain protein
I6G45_RS01465	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G45_RS01470	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G45_RS01475	COG1882	Formate acetyltransferase
I6G45_RS01480	COG1349	DNA-binding transcription factor activity
I6G45_RS01505	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6G45_RS01505	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6G45_RS01510	COG0802	atpase or kinase
I6G45_RS01515	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G45_RS01520	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6G45_RS01530	COG1923	regulation of RNA biosynthetic process
I6G45_RS01535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G45_RS01540	COG0330	HflC and HflK could
I6G45_RS01545	COG0330	HflC and HflK could
I6G45_RS01550	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6G45_RS01565	COG0557	exoribonuclease II activity
I6G45_RS01585	COG1960	acyl-CoA dehydrogenase activity
I6G45_RS01590	COG0840	transmembrane signaling receptor activity
I6G45_RS01600	COG3650	response to hydrogen peroxide
I6G45_RS01605	COG1073	alpha beta
I6G45_RS01625	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6G45_RS01640	COG3061	Opacity-associated protein A
I6G45_RS01645	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G45_RS01650	COG1113	amino acid transport
I6G45_RS01660	COG0697	spore germination
I6G45_RS01665	COG2169	Transcriptional regulator
I6G45_RS01665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G45_RS01670	COG0702	epimerase
I6G45_RS01675	COG1733	regulation of RNA biosynthetic process
I6G45_RS01685	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6G45_RS01690	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6G45_RS01700	COG1253	flavin adenine dinucleotide binding
I6G45_RS01705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G45_RS01710	COG0729	surface antigen
I6G45_RS01715	COG2911	Protein conserved in bacteria
I6G45_RS01720	COG2105	PFAM AIG2 family protein
I6G45_RS01735	COG3188	usher protein
I6G45_RS01760	COG3539	Fimbrial protein
I6G45_RS01775	COG1879	ABC-type sugar transport system periplasmic component
I6G45_RS01780	COG1129	ABC transporter
I6G45_RS01785	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G45_RS01790	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G45_RS01805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G45_RS01810	COG0493	'glutamate synthase
I6G45_RS01815	COG0070	glutamate synthase
I6G45_RS01815	COG0069	glutamate synthase activity
I6G45_RS01815	COG0067	glutamate synthase
I6G45_RS01820	COG1242	4 iron, 4 sulfur cluster binding
I6G45_RS01825	COG2198	Histidine kinase
I6G45_RS01825	COG5002	protein histidine kinase activity
I6G45_RS01825	COG0784	Response regulator, receiver
I6G45_RS01830	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6G45_RS01840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G45_RS01860	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6G45_RS01865	COG1137	ATPase activity
I6G45_RS01870	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6G45_RS01875	COG3117	lipopolysaccharide transmembrane transporter activity
I6G45_RS01880	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6G45_RS01890	COG0530	calcium, potassium:sodium antiporter activity
I6G45_RS01895	COG1127	ABC transporter
I6G45_RS01900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6G45_RS01905	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G45_RS01910	COG2854	intermembrane phospholipid transfer
I6G45_RS01915	COG3113	response to antibiotic
I6G45_RS01920	COG5007	Belongs to the BolA IbaG family
I6G45_RS01930	COG3423	Transcriptional regulator
I6G45_RS01935	COG0142	geranyltranstransferase activity
I6G45_RS01940	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6G45_RS01950	COG0697	spore germination
I6G45_RS01960	COG2027	D-alanyl-D-alanine carboxypeptidase
I6G45_RS01965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G45_RS01970	COG1534	Rna-binding protein
I6G45_RS01975	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6G45_RS01985	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G45_RS02000	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G45_RS02020	COG0195	Participates in both transcription termination and antitermination
I6G45_RS02035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6G45_RS02040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6G45_RS02060	COG0513	Belongs to the DEAD box helicase family
I6G45_RS02065	COG0814	amino acid
I6G45_RS02070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G45_RS02075	COG0826	peptidase U32
I6G45_RS02080	COG0826	peptidase U32
I6G45_RS02085	COG3154	lipid carrier protein
I6G45_RS02090	COG3153	acetyltransferase
I6G45_RS02095	COG2827	Endonuclease containing a URI domain
I6G45_RS02105	COG0693	protein deglycase activity
I6G45_RS02110	COG0702	epimerase
I6G45_RS02115	COG2823	Periplasmic or secreted lipoprotein
I6G45_RS02120	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6G45_RS02135	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6G45_RS02145	COG2721	sulfolactate sulfo-lyase activity
I6G45_RS02150	COG2271	Major facilitator Superfamily
I6G45_RS02155	COG3836	Belongs to the HpcH HpaI aldolase family
I6G45_RS02160	COG2084	Dehydrogenase
I6G45_RS02165	COG1929	Belongs to the glycerate kinase type-1 family
I6G45_RS02175	COG0604	alcohol dehydrogenase
I6G45_RS02180	COG0583	DNA-binding transcription factor activity
I6G45_RS02200	COG0438	transferase activity, transferring glycosyl groups
I6G45_RS02210	COG0110	maltose O-acetyltransferase activity
I6G45_RS02240	COG0488	(ABC) transporter
I6G45_RS02245	COG0741	lytic transglycosylase activity
I6G45_RS02265	COG3708	Transcriptional regulator
I6G45_RS02265	COG2207	Transcriptional regulator
I6G45_RS02270	COG3045	CreA protein
I6G45_RS02275	COG0745	RESPONSE REGULATOR receiver
I6G45_RS02280	COG2205	protein histidine kinase activity
I6G45_RS02285	COG4452	Inner membrane protein CreD
I6G45_RS02290	COG0745	RESPONSE REGULATOR receiver
I6G45_RS02300	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6G45_RS02310	COG0527	aspartate kinase activity
I6G45_RS02310	COG0460	homoserine dehydrogenase
I6G45_RS02320	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6G45_RS02330	COG1115	amino acid carrier protein
I6G45_RS02340	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G45_RS02345	COG0477	Major facilitator Superfamily
I6G45_RS02355	COG3119	arylsulfatase activity
I6G45_RS02360	COG0641	radical SAM
I6G45_RS02370	COG1584	GPR1 FUN34 yaaH family protein
I6G45_RS02390	COG0583	DNA-binding transcription factor activity
I6G45_RS02395	COG0268	Binds directly to 16S ribosomal RNA
I6G45_RS02405	COG0196	riboflavin kinase activity
I6G45_RS02420	COG1047	Peptidyl-prolyl cis-trans
I6G45_RS02430	COG0346	lactoylglutathione lyase activity
I6G45_RS02435	COG2223	nitrite transmembrane transporter activity
I6G45_RS02440	COG1349	DNA-binding transcription factor activity
I6G45_RS02445	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6G45_RS02485	COG0505	Belongs to the CarA family
I6G45_RS02495	COG0789	Transcriptional regulator
I6G45_RS02500	COG2200	EAL domain
I6G45_RS02560	COG2967	ApaG domain
I6G45_RS02575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G45_RS02580	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6G45_RS02585	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6G45_RS02590	COG0564	pseudouridine synthase activity
I6G45_RS02600	COG0417	DNA replication proofreading
I6G45_RS02610	COG0235	Class ii aldolase
I6G45_RS02615	COG2160	L-arabinose isomerase activity
I6G45_RS02630	COG0586	Pfam SNARE associated Golgi protein
I6G45_RS02635	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6G45_RS02640	COG1178	ABC-type Fe3 transport system permease component
I6G45_RS02645	COG4143	(ABC) transporter
I6G45_RS02655	COG2814	Major facilitator Superfamily
I6G45_RS02690	COG0028	Belongs to the TPP enzyme family
I6G45_RS02700	COG1609	Transcriptional regulator
I6G45_RS02720	COG0768	penicillin binding
I6G45_RS02725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G45_RS02730	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G45_RS02740	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6G45_RS02745	COG0772	Belongs to the SEDS family
I6G45_RS02770	COG0849	cell division
I6G45_RS02775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6G45_RS02795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G45_RS02810	COG0762	integral membrane protein
I6G45_RS02815	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6G45_RS02820	COG2805	Type II/IV secretion system protein
I6G45_RS02840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G45_RS02845	COG2356	endonuclease I
I6G45_RS02855	COG2814	Major facilitator Superfamily
I6G45_RS02875	COG1166	arginine decarboxylase activity
I6G45_RS02885	COG0501	Belongs to the peptidase M48B family
I6G45_RS02890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G45_RS02895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G45_RS02900	COG2213	PTS system mannitol-specific
I6G45_RS02905	COG1063	alcohol dehydrogenase
I6G45_RS02910	COG1494	fructose-1,6-bisphosphatase
I6G45_RS02920	COG1072	(Pantothenic acid kinase))
I6G45_RS02925	COG1122	ATPase activity
I6G45_RS02930	COG1122	ATPase activity
I6G45_RS02950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G45_RS02955	COG0126	phosphoglycerate kinase activity
I6G45_RS02960	COG0191	fructose-bisphosphate aldolase activity
I6G45_RS02965	COG0668	transmembrane transport
I6G45_RS02975	COG2968	Membrane
I6G45_RS02990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G45_RS02995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G45_RS03010	COG3079	Belongs to the UPF0149 family
I6G45_RS03015	COG0006	proline dipeptidase activity
I6G45_RS03020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G45_RS03025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G45_RS03045	COG1028	Short-chain dehydrogenase reductase Sdr
I6G45_RS03050	COG1858	cytochrome C peroxidase
I6G45_RS03055	COG2723	6-phospho-beta-galactosidase activity
I6G45_RS03060	COG1737	Transcriptional regulator
I6G45_RS03070	COG1272	protein, Hemolysin III
I6G45_RS03080	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6G45_RS03090	COG0716	FMN binding
I6G45_RS03105	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6G45_RS03120	COG2233	PERMEase
I6G45_RS03125	COG0493	'glutamate synthase
I6G45_RS03125	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G45_RS03130	COG2252	PERMEase
I6G45_RS03135	COG0402	S-adenosylhomocysteine deaminase activity
I6G45_RS03140	COG2233	PERMEase
I6G45_RS03145	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G45_RS03145	COG2080	2 iron, 2 sulfur cluster binding
I6G45_RS03150	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6G45_RS03155	COG0402	S-adenosylhomocysteine deaminase activity
I6G45_RS03160	COG0493	'glutamate synthase
I6G45_RS03160	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G45_RS03165	COG2068	MobA-Related Protein
I6G45_RS03170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G45_RS03175	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6G45_RS03175	COG3608	succinylglutamate desuccinylase aspartoacylase
I6G45_RS03180	COG0549	Belongs to the carbamate kinase family
I6G45_RS03190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G45_RS03195	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G45_RS03200	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6G45_RS03205	COG3829	transcription factor binding
I6G45_RS03210	COG2080	2 iron, 2 sulfur cluster binding
I6G45_RS03215	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6G45_RS03220	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G45_RS03225	COG4942	peptidase
I6G45_RS03245	COG0583	DNA-binding transcription factor activity
I6G45_RS03255	COG0183	Belongs to the thiolase family
I6G45_RS03260	COG1028	Short-chain dehydrogenase reductase Sdr
I6G45_RS03270	COG1794	racemase activity, acting on amino acids and derivatives
I6G45_RS03275	COG0583	DNA-binding transcription factor activity
I6G45_RS03290	COG1609	Transcriptional regulator
I6G45_RS03295	COG0318	PFAM AMP-dependent synthetase and ligase
I6G45_RS03295	COG0204	Acyl-transferase
I6G45_RS03305	COG0667	Aldo Keto reductase
I6G45_RS03335	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6G45_RS03340	COG2165	general secretion pathway protein
I6G45_RS03345	COG4795	General secretion pathway protein
I6G45_RS03355	COG4967	type IV pilus modification protein PilV
I6G45_RS03360	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6G45_RS03370	COG1074	ATP-dependent DNA helicase activity
I6G45_RS03375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G45_RS03380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G45_RS03380	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6G45_RS03385	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G45_RS03405	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6G45_RS03410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6G45_RS03415	COG2166	iron-sulfur cluster assembly
I6G45_RS03420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G45_RS03430	COG0583	DNA-binding transcription factor activity
I6G45_RS03435	COG2363	Small membrane protein
I6G45_RS03450	COG1760	l-serine dehydratase
I6G45_RS03455	COG0814	amino acid
I6G45_RS03460	COG1611	Belongs to the LOG family
I6G45_RS03475	COG3098	single-species biofilm formation
I6G45_RS03480	COG0564	pseudouridine synthase activity
I6G45_RS03485	COG0716	FMN binding
I6G45_RS03490	COG2271	Major facilitator Superfamily
I6G45_RS03495	COG4948	Mandelate Racemase Muconate Lactonizing
I6G45_RS03500	COG4948	Mandelate Racemase Muconate Lactonizing
I6G45_RS03505	COG1929	Belongs to the glycerate kinase type-1 family
I6G45_RS03510	COG4999	Histidine kinase
I6G45_RS03510	COG2205	protein histidine kinase activity
I6G45_RS03510	COG3850	Histidine kinase
I6G45_RS03510	COG3437	response regulator, receiver
I6G45_RS03515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G45_RS03520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G45_RS03525	COG3956	TIGRFAM MazG family protein
I6G45_RS03535	COG0148	phosphopyruvate hydratase activity
I6G45_RS03545	COG1737	Transcriptional regulator
I6G45_RS03550	COG2190	(PTS) system
I6G45_RS03550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G45_RS03550	COG1263	PTS System
I6G45_RS03555	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6G45_RS03560	COG0602	queuosine metabolic process
I6G45_RS03565	COG0720	synthase
I6G45_RS03585	COG2234	aminopeptidase activity
I6G45_RS03645	COG1388	LysM domain
I6G45_RS03645	COG4942	peptidase
I6G45_RS03665	COG2951	lytic endotransglycosylase activity
I6G45_RS03670	COG1546	Belongs to the CinA family
I6G45_RS03690	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6G45_RS03720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G45_RS03725	COG1238	metal cluster binding
I6G45_RS03735	COG1854	S-ribosylhomocysteine lyase activity
I6G45_RS03740	COG2814	Major facilitator Superfamily
I6G45_RS03745	COG1566	PFAM secretion protein HlyD family protein
I6G45_RS03750	COG1846	Transcriptional regulator
I6G45_RS03760	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6G45_RS03765	COG2814	Major facilitator Superfamily
I6G45_RS03790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G45_RS03800	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6G45_RS03805	COG4575	ribosome binding
I6G45_RS03825	COG0401	homolog of Blt101
I6G45_RS03830	COG0252	asparaginase activity
I6G45_RS03835	COG1278	Cold shock
I6G45_RS03840	COG0519	Catalyzes the synthesis of GMP from XMP
I6G45_RS03930	COG0582	viral genome integration into host DNA
I6G45_RS03950	COG1132	(ABC) transporter
I6G45_RS03955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G45_RS03965	COG2867	negative regulation of translational initiation
I6G45_RS03985	COG0497	DNA recombination
I6G45_RS04000	COG4536	flavin adenine dinucleotide binding
I6G45_RS04005	COG4137	Cytochrome C assembly protein
I6G45_RS04010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G45_RS04050	COG2885	chlorophyll binding
I6G45_RS04055	COG2199	diguanylate cyclase activity
I6G45_RS04070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G45_RS04075	COG0287	Prephenate dehydrogenase
I6G45_RS04075	COG1605	Chorismate mutase
I6G45_RS04080	COG0077	Prephenate dehydratase
I6G45_RS04080	COG1605	Chorismate mutase
I6G45_RS04090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6G45_RS04095	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G45_RS04110	COG0542	response to heat
I6G45_RS04145	COG5544	Lipoprotein
I6G45_RS04150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G45_RS04160	COG3148	PFAM DTW domain containing protein
I6G45_RS04165	COG3118	belongs to the thioredoxin family
I6G45_RS04170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G45_RS04185	COG0513	Belongs to the DEAD box helicase family
I6G45_RS04195	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6G45_RS04215	COG3026	antisigma factor binding
I6G45_RS04220	COG3086	response to oxidative stress
I6G45_RS04225	COG0840	transmembrane signaling receptor activity
I6G45_RS04235	COG0681	Belongs to the peptidase S26 family
I6G45_RS04255	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6G45_RS04265	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G45_RS04280	COG1737	Transcriptional regulator
I6G45_RS04285	COG0560	Phosphoserine phosphatase
I6G45_RS04300	COG0047	phosphoribosylformylglycinamidine synthase activity
I6G45_RS04300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G45_RS04305	COG2205	protein histidine kinase activity
I6G45_RS04310	COG3170	Tfp pilus assembly protein FimV
I6G45_RS04315	COG2204	response regulator
I6G45_RS04320	COG0347	Belongs to the P(II) protein family
I6G45_RS04330	COG3923	Primosomal replication protein n
I6G45_RS04335	COG2832	Protein of unknown function (DUF454)
I6G45_RS04365	COG0563	adenylate kinase activity
I6G45_RS04375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G45_RS04380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G45_RS04380	COG4651	solute:proton antiporter activity
I6G45_RS04385	COG2223	nitrite transmembrane transporter activity
I6G45_RS04400	COG3735	TraB family
I6G45_RS04410	COG1203	CRISPR-associated helicase, Cas3
I6G45_RS04425	COG1857	crispr-associated protein
I6G45_RS04440	COG1518	maintenance of DNA repeat elements
I6G45_RS04445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G45_RS04455	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6G45_RS04460	COG0330	HflC and HflK could
I6G45_RS04465	COG3118	belongs to the thioredoxin family
I6G45_RS04470	COG0300	oxidoreductase activity
I6G45_RS04475	COG2755	lipolytic protein G-D-S-L family
I6G45_RS04480	COG4181	ATPase activity
I6G45_RS04485	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6G45_RS04495	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6G45_RS04500	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6G45_RS04505	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G45_RS04510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G45_RS04520	COG1988	membrane-bound metal-dependent
I6G45_RS04525	COG1028	Short-chain dehydrogenase reductase Sdr
I6G45_RS04530	COG1609	Transcriptional regulator
I6G45_RS04535	COG2190	(PTS) system
I6G45_RS04535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G45_RS04535	COG1263	PTS System
I6G45_RS04545	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G45_RS04550	COG2501	S4 domain
I6G45_RS04565	COG2203	Gaf domain
I6G45_RS04565	COG5001	Diguanylate cyclase
I6G45_RS04565	COG4251	negative regulation of phosphorylation
I6G45_RS04565	COG3706	GGDEF domain
I6G45_RS04570	COG4565	transcriptional regulatory protein
I6G45_RS04575	COG3290	protein histidine kinase activity
I6G45_RS04580	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6G45_RS04590	COG2301	Belongs to the HpcH HpaI aldolase family
I6G45_RS04595	COG3051	citrate lyase alpha subunit
I6G45_RS04610	COG0471	metal ion transport
I6G45_RS04630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G45_RS04640	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G45_RS04645	COG0651	ATP synthesis coupled electron transport
I6G45_RS04650	COG0650	Formate hydrogenlyase subunit 4
I6G45_RS04655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G45_RS04660	COG4237	Hydrogenase 4 membrane
I6G45_RS04665	COG0651	ATP synthesis coupled electron transport
I6G45_RS04670	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6G45_RS04670	COG3261	NADH dehydrogenase
I6G45_RS04675	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G45_RS04680	COG3260	NADH ubiquinone oxidoreductase 20
I6G45_RS04690	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6G45_RS04695	COG3604	Transcriptional regulator
I6G45_RS04700	COG2116	formate transmembrane transporter activity
I6G45_RS04705	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G45_RS04710	COG3383	formate dehydrogenase (NAD+) activity
I6G45_RS04715	COG3615	Tellurite resistance protein tehB
I6G45_RS04725	COG2864	formate dehydrogenase
I6G45_RS04730	COG0437	4 iron, 4 sulfur cluster binding
I6G45_RS04735	COG3383	formate dehydrogenase (NAD+) activity
I6G45_RS04735	COG0243	molybdopterin cofactor binding
I6G45_RS04750	COG0814	amino acid
I6G45_RS04760	COG1063	alcohol dehydrogenase
I6G45_RS04775	COG1129	ABC transporter
I6G45_RS04780	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G45_RS04790	COG0656	L-ascorbic acid biosynthetic process
I6G45_RS04795	COG1070	Carbohydrate kinase
I6G45_RS04800	COG1349	DNA-binding transcription factor activity
I6G45_RS04820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G45_RS04825	COG0601	transmembrane transport
I6G45_RS04830	COG0747	negative chemotaxis
I6G45_RS04835	COG1305	Transglutaminase-like
I6G45_RS04845	COG2608	mercury ion transmembrane transporter activity
I6G45_RS04850	COG0375	protein maturation
I6G45_RS04855	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6G45_RS04860	COG0298	carbon dioxide binding
I6G45_RS04865	COG0409	Hydrogenase expression formation protein
I6G45_RS04870	COG0309	Hydrogenase expression formation protein (HypE)
I6G45_RS04875	COG0640	Transcriptional regulator
I6G45_RS04910	COG0583	DNA-binding transcription factor activity
I6G45_RS04920	COG0477	Major facilitator Superfamily
I6G45_RS04950	COG0840	transmembrane signaling receptor activity
I6G45_RS04970	COG0700	Nucleoside recognition
I6G45_RS04975	COG3366	ferrous iron transmembrane transporter activity
I6G45_RS04980	COG2977	Belongs to the P-Pant transferase superfamily
I6G45_RS04985	COG4771	TonB-dependent receptor
I6G45_RS04990	COG2382	esterase
I6G45_RS04995	COG3251	PFAM MbtH domain protein
I6G45_RS05000	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6G45_RS05000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G45_RS05010	COG1120	ATPase activity
I6G45_RS05015	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G45_RS05020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G45_RS05025	COG0477	Major facilitator Superfamily
I6G45_RS05030	COG4592	Periplasmic binding protein
I6G45_RS05035	COG1169	isochorismate synthase
I6G45_RS05040	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6G45_RS05045	COG1535	isochorismatase
I6G45_RS05045	COG3433	isochorismatase activity
I6G45_RS05050	COG1028	Short-chain dehydrogenase reductase Sdr
I6G45_RS05055	COG2050	protein possibly involved in aromatic compounds catabolism
I6G45_RS05060	COG0436	Aminotransferase
I6G45_RS05065	COG0583	DNA-binding transcription factor activity
I6G45_RS05070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G45_RS05075	COG0450	alkyl hydroperoxide reductase
I6G45_RS05080	COG3634	alkyl hydroperoxide reductase activity
I6G45_RS05090	COG1063	alcohol dehydrogenase
I6G45_RS05095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G45_RS05110	COG3719	Belongs to the RNase T2 family
I6G45_RS05115	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G45_RS05135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G45_RS05140	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G45_RS05160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G45_RS05175	COG0321	lipoyl(octanoyl) transferase activity
I6G45_RS05185	COG1686	Belongs to the peptidase S11 family
I6G45_RS05190	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6G45_RS05195	COG0772	Belongs to the SEDS family
I6G45_RS05200	COG0768	penicillin binding
I6G45_RS05210	COG0799	negative regulation of ribosome biogenesis
I6G45_RS05220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G45_RS05230	COG1466	dna polymerase III delta subunit
I6G45_RS05245	COG2888	peptidyl-tyrosine sulfation
I6G45_RS05250	COG1126	abc transporter atp-binding protein
I6G45_RS05255	COG0765	amino acid transport
I6G45_RS05260	COG0765	amino acid transport
I6G45_RS05270	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6G45_RS05280	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6G45_RS05285	COG1702	phosphate starvation-inducible protein PhoH
I6G45_RS05295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G45_RS05335	COG0367	asparagine synthase
I6G45_RS05340	COG0647	UMP catabolic process
I6G45_RS05345	COG1940	carbohydrate kinase activity
I6G45_RS05345	COG1846	Transcriptional regulator
I6G45_RS05350	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G45_RS05360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G45_RS05360	COG1263	PTS System
I6G45_RS05360	COG2190	(PTS) system
I6G45_RS05375	COG0735	belongs to the Fur family
I6G45_RS05390	COG0596	Alpha beta hydrolase
I6G45_RS05395	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6G45_RS05400	COG0033	Phosphoglucomutase
I6G45_RS05405	COG0531	amino acid
I6G45_RS05410	COG1982	Orn Lys Arg decarboxylase major
I6G45_RS05420	COG0745	RESPONSE REGULATOR receiver
I6G45_RS05425	COG2205	protein histidine kinase activity
I6G45_RS05430	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6G45_RS05435	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6G45_RS05455	COG3272	Protein of unknown function (DUF1722)
I6G45_RS05460	COG0415	Belongs to the DNA photolyase family
I6G45_RS05470	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6G45_RS05475	COG1984	allophanate hydrolase subunit 2
I6G45_RS05510	COG0372	Belongs to the citrate synthase family
I6G45_RS05515	COG2009	succinate dehydrogenase
I6G45_RS05520	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6G45_RS05525	COG1053	succinate dehydrogenase
I6G45_RS05535	COG0567	Dehydrogenase, E1 component
I6G45_RS05540	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G45_RS05550	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6G45_RS05555	COG1271	oxidase subunit
I6G45_RS05560	COG1294	oxidase, subunit
I6G45_RS05565	COG4890	Cyd operon protein YbgT
I6G45_RS05570	COG3790	cyd operon protein YbgE
I6G45_RS05575	COG0824	Thioesterase
I6G45_RS05580	COG0811	peptide transport
I6G45_RS05585	COG0848	biopolymer transport protein
I6G45_RS05590	COG3064	Membrane
I6G45_RS05600	COG2885	chlorophyll binding
I6G45_RS05605	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6G45_RS05650	COG1230	cation diffusion facilitator family transporter
I6G45_RS05660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G45_RS05670	COG2017	converts alpha-aldose to the beta-anomer
I6G45_RS05680	COG1085	galactose-1-phosphate uridylyltransferase
I6G45_RS05690	COG1119	ATPase activity
I6G45_RS05695	COG2005	Transcriptional regulator
I6G45_RS05695	COG3585	molybdate ion transport
I6G45_RS05705	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6G45_RS05710	COG4149	molybdate abc transporter
I6G45_RS05720	COG0561	phosphatase activity
I6G45_RS05725	COG2706	6-phosphogluconolactonase activity
I6G45_RS05730	COG4677	pectinesterase activity
I6G45_RS05760	COG1881	PFAM PEBP family protein
I6G45_RS05765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G45_RS05780	COG2226	methyltransferase
I6G45_RS05785	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6G45_RS05790	COG0410	ABC transporter
I6G45_RS05810	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G45_RS05820	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6G45_RS05825	COG0314	molybdopterin synthase activity
I6G45_RS05830	COG0670	Belongs to the BI1 family
I6G45_RS05845	COG3121	Chaperone
I6G45_RS05850	COG3188	usher protein
I6G45_RS05860	COG0392	lysyltransferase activity
I6G45_RS05865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G45_RS05870	COG3568	Endonuclease Exonuclease Phosphatase
I6G45_RS05880	COG0842	Transport permease protein
I6G45_RS05885	COG0842	Transport permease protein
I6G45_RS05890	COG1131	(ABC) transporter
I6G45_RS05895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G45_RS05900	COG1309	transcriptional regulator
I6G45_RS05905	COG0513	Belongs to the DEAD box helicase family
I6G45_RS05915	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G45_RS05925	COG2252	PERMEase
I6G45_RS05940	COG0668	transmembrane transport
I6G45_RS05945	COG1126	abc transporter atp-binding protein
I6G45_RS05950	COG0765	amino acid transport
I6G45_RS05955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G45_RS05960	COG0783	Belongs to the Dps family
I6G45_RS05970	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6G45_RS05975	COG2194	sulfuric ester hydrolase activity
I6G45_RS05985	COG1321	iron dependent repressor
I6G45_RS05990	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6G45_RS05995	COG1376	ErfK ybiS ycfS ynhG family protein
I6G45_RS06000	COG0488	(ABC) transporter
I6G45_RS06005	COG1253	flavin adenine dinucleotide binding
I6G45_RS06025	COG0463	Glycosyl transferase, family 2
I6G45_RS06030	COG1045	serine acetyltransferase
I6G45_RS06035	COG0438	transferase activity, transferring glycosyl groups
I6G45_RS06045	COG1216	Glycosyl transferase, family 2
I6G45_RS06050	COG0110	maltose O-acetyltransferase activity
I6G45_RS06055	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6G45_RS06060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G45_RS06065	COG1051	belongs to the nudix hydrolase family
I6G45_RS06070	COG0297	glycogen (starch) synthase activity
I6G45_RS06080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G45_RS06085	COG2244	polysaccharide biosynthetic process
I6G45_RS06090	COG2327	Polysaccharide pyruvyl transferase
I6G45_RS06095	COG0438	transferase activity, transferring glycosyl groups
I6G45_RS06145	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6G45_RS06170	COG0463	Glycosyl transferase, family 2
I6G45_RS06180	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6G45_RS06185	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6G45_RS06185	COG0140	phosphoribosyl-ATP diphosphatase activity
I6G45_RS06200	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6G45_RS06205	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6G45_RS06205	COG0131	Imidazoleglycerol-phosphate dehydratase
I6G45_RS06220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6G45_RS06230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G45_RS06235	COG0583	DNA-binding transcription factor activity
I6G45_RS06245	COG0531	amino acid
I6G45_RS06250	COG2925	Exonuclease
I6G45_RS06260	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6G45_RS06265	COG1289	transmembrane transporter activity
I6G45_RS06270	COG2926	Belongs to the UPF0265 family
I6G45_RS06290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G45_RS06305	COG0791	NLP P60 protein
I6G45_RS06320	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G45_RS06365	COG0583	DNA-binding transcription factor activity
I6G45_RS06375	COG0534	Mate efflux family protein
I6G45_RS06380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G45_RS06385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G45_RS06390	COG1121	(ABC) transporter
I6G45_RS06395	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G45_RS06400	COG1376	ErfK ybiS ycfS ynhG family protein
I6G45_RS06430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G45_RS06440	COG1418	mRNA catabolic process
I6G45_RS06445	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6G45_RS06450	COG3727	T/G mismatch-specific endonuclease activity
I6G45_RS06455	COG0697	spore germination
I6G45_RS06460	COG2354	Protein conserved in bacteria
I6G45_RS06465	COG5475	Uncharacterized small protein (DUF2158)
I6G45_RS06490	COG2197	response regulator
I6G45_RS06505	COG1338	Plays a role in the flagellum-specific transport system
I6G45_RS06515	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G45_RS06525	COG1580	Controls the rotational direction of flagella during chemotaxis
I6G45_RS06540	COG1157	protein secretion by the type III secretion system
I6G45_RS06545	COG1317	bacterial-type flagellum organization
I6G45_RS06550	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G45_RS06580	COG0425	Belongs to the sulfur carrier protein TusA family
I6G45_RS06595	COG0366	Alpha amylase catalytic
I6G45_RS06620	COG1191	sigma factor activity
I6G45_RS06630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G45_RS06640	COG0765	amino acid transport
I6G45_RS06645	COG1126	abc transporter atp-binding protein
I6G45_RS06650	COG2197	response regulator
I6G45_RS06660	COG2197	response regulator
I6G45_RS06690	COG4302	ethanolamine ammonia-lyase activity
I6G45_RS06695	COG4303	Ethanolamine ammonia lyase large subunit
I6G45_RS06705	COG2040	homocysteine
I6G45_RS06710	COG3318	Belongs to the UPF0149 family
I6G45_RS06710	COG3012	SEC-C Motif Domain Protein
I6G45_RS06715	COG3005	denitrification pathway
I6G45_RS06720	COG0243	molybdopterin cofactor binding
I6G45_RS06725	COG0814	amino acid
I6G45_RS06735	COG1528	Iron-storage protein
I6G45_RS06760	COG0243	molybdopterin cofactor binding
I6G45_RS06780	COG3381	protein complex oligomerization
I6G45_RS06805	COG2197	response regulator
I6G45_RS06835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G45_RS06850	COG2943	transferase activity, transferring hexosyl groups
I6G45_RS06855	COG5645	(Lipo)protein
I6G45_RS06865	COG1560	Kdo2-lipid A biosynthetic process
I6G45_RS06875	COG2353	YceI-like domain
I6G45_RS06880	COG3038	cytochrome b561
I6G45_RS06910	COG2999	glutathione oxidoreductase activity
I6G45_RS06920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G45_RS06935	COG0728	peptidoglycan biosynthetic process
I6G45_RS06945	COG0671	phosphoesterase, PA-phosphatase related
I6G45_RS06945	COG2453	phosphatase
I6G45_RS06950	COG2267	carboxylic ester hydrolase activity
I6G45_RS06960	COG4589	Belongs to the CDS family
I6G45_RS06965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G45_RS06985	COG1815	bacterial-type flagellum-dependent cell motility
I6G45_RS07040	COG1475	DNA binding
I6G45_RS07045	COG3969	phosphoadenosine phosphosulfate
I6G45_RS07050	COG2814	Major facilitator Superfamily
I6G45_RS07060	COG1530	ribonuclease E activity
I6G45_RS07060	COG1530	ribonuclease E activity
I6G45_RS07070	COG0424	maF-like protein
I6G45_RS07075	COG1399	metal-binding, possibly nucleic acid-binding protein
I6G45_RS07095	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6G45_RS07100	COG1028	Short-chain dehydrogenase reductase Sdr
I6G45_RS07110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G45_RS07115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G45_RS07120	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G45_RS07130	COG0470	DNA polymerase III
I6G45_RS07135	COG0084	hydrolase, TatD family'
I6G45_RS07140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G45_RS07140	COG1263	PTS System
I6G45_RS07145	COG4773	Receptor
I6G45_RS07150	COG1064	alcohol dehydrogenase
I6G45_RS07155	COG0537	adenosine 5'-monophosphoramidase activity
I6G45_RS07160	COG5633	Lipoprotein
I6G45_RS07185	COG1252	NADH dehydrogenase
I6G45_RS07190	COG3134	Outer membrane lipoprotein
I6G45_RS07195	COG2719	SpoVR family
I6G45_RS07210	COG3263	regulation of cellular component size
I6G45_RS07215	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6G45_RS07240	COG1116	anion transmembrane transporter activity
I6G45_RS07255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G45_RS07260	COG0672	)-iron permease
I6G45_RS07275	COG1136	(ABC) transporter
I6G45_RS07275	COG0577	efflux transmembrane transporter activity
I6G45_RS07285	COG0577	efflux transmembrane transporter activity
I6G45_RS07285	COG1136	(ABC) transporter
I6G45_RS07290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G45_RS07315	COG4297	protein containing double-stranded beta helix domain
I6G45_RS07365	COG4977	sequence-specific DNA binding
I6G45_RS07375	COG3122	Protein conserved in bacteria
I6G45_RS07400	COG2831	hemolysin activation secretion protein
I6G45_RS07405	COG2994	toxin metabolic process
I6G45_RS07410	COG3210	domain, Protein
I6G45_RS07430	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6G45_RS07430	COG0456	acetyltransferase
I6G45_RS07440	COG0386	Belongs to the glutathione peroxidase family
I6G45_RS07455	COG2207	Transcriptional regulator
I6G45_RS07465	COG1309	transcriptional regulator
I6G45_RS07475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G45_RS07480	COG0012	GTP binding
I6G45_RS07500	COG0659	secondary active sulfate transmembrane transporter activity
I6G45_RS07505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G45_RS07530	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G45_RS07545	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6G45_RS07550	COG0387	Pfam Sodium calcium exchanger
I6G45_RS07555	COG4572	Cation transport regulator
I6G45_RS07560	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6G45_RS07570	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6G45_RS07575	COG3707	response regulator
I6G45_RS07580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G45_RS07590	COG1116	anion transmembrane transporter activity
I6G45_RS07595	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G45_RS07595	COG2146	nitrite reductase [NAD(P)H] activity
I6G45_RS07600	COG0243	molybdopterin cofactor binding
I6G45_RS07610	COG4932	domain protein
I6G45_RS07615	COG2197	response regulator
I6G45_RS07620	COG3850	Histidine kinase
I6G45_RS07625	COG2223	nitrite transmembrane transporter activity
I6G45_RS07630	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6G45_RS07635	COG1140	nitrate reductase beta subunit
I6G45_RS07640	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6G45_RS07645	COG2181	nitrate reductase activity
I6G45_RS07650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G45_RS07655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G45_RS07715	COG0788	formyltetrahydrofolate deformylase activity
I6G45_RS07730	COG0745	RESPONSE REGULATOR receiver
I6G45_RS07735	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G45_RS07760	COG1012	belongs to the aldehyde dehydrogenase family
I6G45_RS07760	COG1454	alcohol dehydrogenase
I6G45_RS07765	COG2095	MarC family integral membrane protein
I6G45_RS07775	COG0601	transmembrane transport
I6G45_RS07785	COG0444	Belongs to the ABC transporter superfamily
I6G45_RS07790	COG4608	Belongs to the ABC transporter superfamily
I6G45_RS07795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G45_RS07815	COG2350	Protein conserved in bacteria
I6G45_RS07840	COG1028	Short-chain dehydrogenase reductase Sdr
I6G45_RS07850	COG0583	DNA-binding transcription factor activity
I6G45_RS07875	COG1309	transcriptional regulator
I6G45_RS07890	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6G45_RS07895	COG3047	cAMP biosynthetic process
I6G45_RS07920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G45_RS07920	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G45_RS07930	COG0613	PHP domain protein
I6G45_RS07935	COG0009	L-threonylcarbamoyladenylate synthase
I6G45_RS07945	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6G45_RS07950	COG1028	Short-chain dehydrogenase reductase Sdr
I6G45_RS07955	COG0616	signal peptide processing
I6G45_RS07995	COG0671	phosphoesterase, PA-phosphatase related
I6G45_RS08000	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6G45_RS08005	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6G45_RS08015	COG0023	Translation Initiation Factor
I6G45_RS08025	COG1349	DNA-binding transcription factor activity
I6G45_RS08035	COG1024	Enoyl-CoA hydratase
I6G45_RS08040	COG5001	Diguanylate cyclase
I6G45_RS08050	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G45_RS08050	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G45_RS08065	COG4172	Belongs to the ABC transporter superfamily
I6G45_RS08070	COG4171	peptide transport system, permease
I6G45_RS08080	COG4166	transmembrane transport
I6G45_RS08085	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6G45_RS08090	COG1842	Phage shock protein A
I6G45_RS08100	COG1983	PspC domain protein
I6G45_RS08110	COG3106	COG3106 Predicted ATPase
I6G45_RS08115	COG3768	UPF0283 membrane protein
I6G45_RS08125	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6G45_RS08130	COG4948	Mandelate Racemase Muconate Lactonizing
I6G45_RS08135	COG2866	Carboxypeptidase
I6G45_RS08140	COG4166	transmembrane transport
I6G45_RS08145	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6G45_RS08150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6G45_RS08180	COG0840	transmembrane signaling receptor activity
I6G45_RS08195	COG0513	Belongs to the DEAD box helicase family
I6G45_RS08200	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G45_RS08205	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6G45_RS08205	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6G45_RS08205	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G45_RS08205	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6G45_RS08215	COG3042	response to heat
I6G45_RS08220	COG3187	Heat shock protein
I6G45_RS08225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G45_RS08230	COG2911	Protein conserved in bacteria
I6G45_RS08240	COG3784	Protein of unknown function (DUF1318)
I6G45_RS08255	COG1643	Atp-dependent helicase
I6G45_RS08275	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6G45_RS08290	COG3038	cytochrome b561
I6G45_RS08295	COG3615	Tellurite resistance protein tehB
I6G45_RS08315	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G45_RS08335	COG1280	lysine exporter protein (LysE YggA)
I6G45_RS08355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G45_RS08365	COG4993	Dehydrogenase
I6G45_RS08390	COG1846	Transcriptional regulator
I6G45_RS08430	COG1028	Short-chain dehydrogenase reductase Sdr
I6G45_RS08435	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6G45_RS08445	COG4977	sequence-specific DNA binding
I6G45_RS08450	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6G45_RS08465	COG0583	DNA-binding transcription factor activity
I6G45_RS08495	COG2814	Major facilitator Superfamily
I6G45_RS08515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G45_RS08525	COG3300	MHYT domain
I6G45_RS08525	COG5001	Diguanylate cyclase
I6G45_RS08530	COG0110	maltose O-acetyltransferase activity
I6G45_RS08560	COG0840	transmembrane signaling receptor activity
I6G45_RS08565	COG2855	membrane
I6G45_RS08570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G45_RS08575	COG2721	sulfolactate sulfo-lyase activity
I6G45_RS08580	COG2721	sulfolactate sulfo-lyase activity
I6G45_RS08585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6G45_RS08590	COG1028	Short-chain dehydrogenase reductase Sdr
I6G45_RS08595	COG0477	Major facilitator Superfamily
I6G45_RS08605	COG1902	pentaerythritol trinitrate reductase activity
I6G45_RS08610	COG0583	DNA-binding transcription factor activity
I6G45_RS08615	COG5383	Protein conserved in bacteria
I6G45_RS08645	COG0436	Aminotransferase
I6G45_RS08660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G45_RS08665	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G45_RS08670	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6G45_RS08675	COG0500	methyltransferase
I6G45_RS08685	COG3135	benzoate transporter
I6G45_RS08690	COG1396	sequence-specific DNA binding
I6G45_RS08695	COG0826	peptidase U32
I6G45_RS08705	COG1902	pentaerythritol trinitrate reductase activity
I6G45_RS08720	COG1294	oxidase, subunit
I6G45_RS08725	COG1271	oxidase subunit
I6G45_RS08735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G45_RS08740	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6G45_RS08745	COG3842	ATPase activity
I6G45_RS08750	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G45_RS08755	COG1177	transmembrane transport
I6G45_RS08760	COG1012	belongs to the aldehyde dehydrogenase family
I6G45_RS08770	COG0840	transmembrane signaling receptor activity
I6G45_RS08785	COG1546	Belongs to the CinA family
I6G45_RS08790	COG2323	membrane
I6G45_RS08800	COG3111	PFAM Bacterial OB fold (BOF) protein
I6G45_RS08805	COG1609	Transcriptional regulator
I6G45_RS08810	COG2211	Major facilitator Superfamily
I6G45_RS08815	COG0673	inositol 2-dehydrogenase activity
I6G45_RS08825	COG0673	inositol 2-dehydrogenase activity
I6G45_RS08840	COG1696	Membrane protein involved in D-alanine export
I6G45_RS08865	COG3238	Protein conserved in bacteria
I6G45_RS08870	COG1247	-acetyltransferase
I6G45_RS08875	COG1396	sequence-specific DNA binding
I6G45_RS08880	COG1802	Transcriptional regulator
I6G45_RS08890	COG4772	TonB-dependent receptor
I6G45_RS08905	COG0668	transmembrane transport
I6G45_RS08925	COG0625	glutathione transferase activity
I6G45_RS08940	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6G45_RS08945	COG0561	phosphatase activity
I6G45_RS08950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G45_RS08955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G45_RS08955	COG0519	Catalyzes the synthesis of GMP from XMP
I6G45_RS08985	COG1090	epimerase
I6G45_RS09005	COG1028	Short-chain dehydrogenase reductase Sdr
I6G45_RS09045	COG2076	Multidrug Resistance protein
I6G45_RS09050	COG3591	Belongs to the peptidase S1B family
I6G45_RS09055	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6G45_RS09060	COG2814	Major facilitator Superfamily
I6G45_RS09065	COG0583	DNA-binding transcription factor activity
I6G45_RS09070	COG1940	carbohydrate kinase activity
I6G45_RS09075	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6G45_RS09085	COG3706	GGDEF domain
I6G45_RS09090	COG0583	DNA-binding transcription factor activity
I6G45_RS09095	COG1012	belongs to the aldehyde dehydrogenase family
I6G45_RS09100	COG0840	transmembrane signaling receptor activity
I6G45_RS09110	COG2199	diguanylate cyclase activity
I6G45_RS09130	COG0659	secondary active sulfate transmembrane transporter activity
I6G45_RS09135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G45_RS09135	COG2221	Nitrite and sulphite reductase 4Fe-4S
I6G45_RS09140	COG3381	protein complex oligomerization
I6G45_RS09145	COG3302	dmso reductase anchor subunit
I6G45_RS09150	COG0437	4 iron, 4 sulfur cluster binding
I6G45_RS09160	COG2226	methyltransferase
I6G45_RS09165	COG2271	Major facilitator Superfamily
I6G45_RS09205	COG1473	amidohydrolase
I6G45_RS09225	COG2814	Major facilitator Superfamily
I6G45_RS09240	COG0251	oxidation-reduction process
I6G45_RS09245	COG0583	DNA-binding transcription factor activity
I6G45_RS09250	COG0626	cystathionine gamma-synthase activity
I6G45_RS09255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G45_RS09260	COG0814	amino acid
I6G45_RS09265	COG0583	DNA-binding transcription factor activity
I6G45_RS09290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G45_RS09305	COG0251	oxidation-reduction process
I6G45_RS09310	COG1309	transcriptional regulator
I6G45_RS09325	COG1649	PFAM Uncharacterised BCR, COG1649
I6G45_RS09340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G45_RS09345	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6G45_RS09350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G45_RS09355	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6G45_RS09360	COG2080	2 iron, 2 sulfur cluster binding
I6G45_RS09375	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6G45_RS09410	COG1294	oxidase, subunit
I6G45_RS09415	COG1271	oxidase subunit
I6G45_RS09420	COG3381	protein complex oligomerization
I6G45_RS09435	COG0437	4 iron, 4 sulfur cluster binding
I6G45_RS09440	COG0243	molybdopterin cofactor binding
I6G45_RS09445	COG2188	Transcriptional regulator
I6G45_RS09450	COG4821	SIS domain
I6G45_RS09480	COG2723	6-phospho-beta-galactosidase activity
I6G45_RS09490	COG1609	Transcriptional regulator
I6G45_RS09500	COG3284	Transcriptional regulator
I6G45_RS09525	COG3136	membrane protein required for alginate biosynthesis
I6G45_RS09540	COG1560	Kdo2-lipid A biosynthetic process
I6G45_RS09550	COG0339	signal peptide processing
I6G45_RS09555	COG4221	oxidoreductase activity
I6G45_RS09560	COG1802	Transcriptional regulator
I6G45_RS09570	COG0246	Mannitol dehydrogenase
I6G45_RS09580	COG1904	glucuronate isomerase
I6G45_RS09585	COG4948	Mandelate Racemase Muconate Lactonizing
I6G45_RS09600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G45_RS09615	COG1263	PTS System
I6G45_RS09615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G45_RS09650	COG1882	Formate acetyltransferase
I6G45_RS09685	COG4977	sequence-specific DNA binding
I6G45_RS09700	COG2814	Major facilitator Superfamily
I6G45_RS09710	COG2944	sequence-specific DNA binding
I6G45_RS09745	COG0439	Biotin carboxylase
I6G45_RS09755	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6G45_RS09765	COG1879	ABC-type sugar transport system periplasmic component
I6G45_RS09775	COG1129	ABC transporter
I6G45_RS09780	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G45_RS09785	COG3959	Transketolase, thiamine diphosphate binding domain
I6G45_RS09790	COG3958	Transketolase
I6G45_RS09795	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G45_RS09815	COG2076	Multidrug Resistance protein
I6G45_RS09830	COG2223	nitrite transmembrane transporter activity
I6G45_RS09835	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6G45_RS09840	COG1140	nitrate reductase beta subunit
I6G45_RS09845	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6G45_RS09850	COG2181	nitrate reductase activity
I6G45_RS09855	COG2840	Smr protein MutS2
I6G45_RS09865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G45_RS09875	COG1609	Transcriptional regulator
I6G45_RS09885	COG3842	ATPase activity
I6G45_RS09890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G45_RS09895	COG1554	hydrolase, family 65, central catalytic
I6G45_RS09900	COG0673	inositol 2-dehydrogenase activity
I6G45_RS09905	COG1082	Xylose isomerase domain protein TIM barrel
I6G45_RS09910	COG1063	alcohol dehydrogenase
I6G45_RS09915	COG0395	ABC-type sugar transport system, permease component
I6G45_RS09920	COG1175	transmembrane transport
I6G45_RS09925	COG1653	transport
I6G45_RS09930	COG0366	Alpha amylase catalytic
I6G45_RS09935	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6G45_RS09940	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6G45_RS09950	COG0531	amino acid
I6G45_RS09955	COG1028	Short-chain dehydrogenase reductase Sdr
I6G45_RS09960	COG0745	RESPONSE REGULATOR receiver
I6G45_RS09965	COG2205	protein histidine kinase activity
I6G45_RS09970	COG0583	DNA-binding transcription factor activity
I6G45_RS09995	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6G45_RS09995	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6G45_RS10005	COG5339	Protein conserved in bacteria
I6G45_RS10010	COG1609	Transcriptional regulator
I6G45_RS10145	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6G45_RS10155	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6G45_RS10165	COG0673	inositol 2-dehydrogenase activity
I6G45_RS10200	COG4659	FMN binding
I6G45_RS10210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G45_RS10220	COG0625	glutathione transferase activity
I6G45_RS10240	COG3895	Periplasmic Protein
I6G45_RS10265	COG1566	PFAM secretion protein HlyD family protein
I6G45_RS10270	COG1289	transmembrane transporter activity
I6G45_RS10280	COG4989	oxidoreductase activity
I6G45_RS10285	COG3313	Fe-S protein
I6G45_RS10290	COG1309	transcriptional regulator
I6G45_RS10295	COG1902	pentaerythritol trinitrate reductase activity
I6G45_RS10300	COG0346	lactoylglutathione lyase activity
I6G45_RS10310	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6G45_RS10315	COG0791	NLP P60 protein
I6G45_RS10325	COG2814	Major facilitator Superfamily
I6G45_RS10340	COG0583	DNA-binding transcription factor activity
I6G45_RS10345	COG2814	Major facilitator Superfamily
I6G45_RS10350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6G45_RS10355	COG0307	riboflavin synthase, alpha
I6G45_RS10360	COG0534	Mate efflux family protein
I6G45_RS10380	COG1764	response to oxidative stress
I6G45_RS10395	COG1376	ErfK ybiS ycfS ynhG family protein
I6G45_RS10400	COG2166	iron-sulfur cluster assembly
I6G45_RS10410	COG0719	Fe-S assembly protein
I6G45_RS10415	COG0396	ATPase activity
I6G45_RS10420	COG0719	Fe-S assembly protein
I6G45_RS10425	COG0316	Belongs to the HesB IscA family
I6G45_RS10440	COG1278	Cold shock
I6G45_RS10455	COG2050	protein possibly involved in aromatic compounds catabolism
I6G45_RS10460	COG0277	FAD linked oxidase domain protein
I6G45_RS10460	COG0247	lactate metabolic process
I6G45_RS10465	COG0628	permease
I6G45_RS10475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G45_RS10475	COG0574	Belongs to the PEP-utilizing enzyme family
I6G45_RS10480	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6G45_RS10485	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G45_RS10500	COG0791	NLP P60 protein
I6G45_RS10510	COG0386	Belongs to the glutathione peroxidase family
I6G45_RS10560	COG3137	Salt-induced outer membrane protein
I6G45_RS10565	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G45_RS10575	COG3001	Fructosamine kinase
I6G45_RS10585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G45_RS10590	COG1028	Short-chain dehydrogenase reductase Sdr
I6G45_RS10595	COG1988	membrane-bound metal-dependent
I6G45_RS10600	COG1823	symporter activity
I6G45_RS10610	COG0753	catalase activity
I6G45_RS10615	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G45_RS10630	COG0322	excinuclease ABC activity
I6G45_RS10640	COG3678	ATP-independent chaperone mediated protein folding
I6G45_RS10650	COG3724	N-succinylarginine dihydrolase activity
I6G45_RS10660	COG3138	arginine N-succinyltransferase
I6G45_RS10670	COG0708	Exodeoxyribonuclease III
I6G45_RS10675	COG0494	nUDIX hydrolase
I6G45_RS10685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G45_RS10695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G45_RS10705	COG0778	Nitroreductase
I6G45_RS10710	COG0616	signal peptide processing
I6G45_RS10715	COG0252	asparaginase activity
I6G45_RS10720	COG1335	isochorismatase
I6G45_RS10725	COG3139	Protein of unknown function (DUF1315)
I6G45_RS10745	COG0656	L-ascorbic acid biosynthetic process
I6G45_RS10750	COG3713	MltA-interacting MipA family protein
I6G45_RS10755	COG2766	serine protein kinase
I6G45_RS10760	COG2718	Belongs to the UPF0229 family
I6G45_RS10810	COG1196	nuclear chromosome segregation
I6G45_RS10850	COG0740	serine-type endopeptidase activity
I6G45_RS10895	COG3179	chitinase
I6G45_RS10925	COG1403	HNH endonuclease
I6G45_RS10940	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6G45_RS10950	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6G45_RS10960	COG1802	Transcriptional regulator
I6G45_RS10960	COG4626	Terminase
I6G45_RS10990	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6G45_RS11025	COG0582	viral genome integration into host DNA
I6G45_RS11030	COG1652	LysM domain
I6G45_RS11035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G45_RS11045	COG2207	Transcriptional regulator
I6G45_RS11050	COG2807	transmembrane transport
I6G45_RS11055	COG0504	CTP synthase activity
I6G45_RS11060	COG3189	MarR family transcriptional regulator
I6G45_RS11095	COG0538	isocitrate dehydrogenase activity
I6G45_RS11100	COG1187	pseudouridine synthase activity
I6G45_RS11115	COG2915	High frequency lysogenization protein hflD homolog
I6G45_RS11120	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G45_RS11130	COG0745	RESPONSE REGULATOR receiver
I6G45_RS11140	COG2850	peptidyl-arginine hydroxylation
I6G45_RS11160	COG1177	transmembrane transport
I6G45_RS11170	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6G45_RS11180	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G45_RS11190	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G45_RS11195	COG4763	Acyl-transferase
I6G45_RS11200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G45_RS11205	COG1376	ErfK ybiS ycfS ynhG family protein
I6G45_RS11205	COG1388	LysM domain
I6G45_RS11230	COG2841	Protein conserved in bacteria
I6G45_RS11595	COG0629	single-stranded DNA binding
I6G45_RS11645	COG0582	viral genome integration into host DNA
I6G45_RS11655	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G45_RS11660	COG2951	lytic endotransglycosylase activity
I6G45_RS11675	COG2894	cell division
I6G45_RS11695	COG3065	identical protein binding
I6G45_RS11705	COG1199	ATP-dependent helicase activity
I6G45_RS11710	COG0251	oxidation-reduction process
I6G45_RS11730	COG1760	l-serine dehydratase
I6G45_RS11735	COG2200	EAL domain
I6G45_RS11740	COG1253	flavin adenine dinucleotide binding
I6G45_RS11745	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G45_RS11745	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G45_RS11750	COG3715	PTS system
I6G45_RS11755	COG3716	PTS system mannose fructose sorbose family IID component
I6G45_RS11760	COG4811	Protein of unknown function (DUF986)
I6G45_RS11770	COG2226	methyltransferase
I6G45_RS11805	COG1414	Transcriptional regulator
I6G45_RS11810	COG2814	Major facilitator Superfamily
I6G45_RS11830	COG1956	GAF domain-containing protein
I6G45_RS11835	COG2995	paraquat-inducible protein a
I6G45_RS11840	COG3008	intermembrane lipid transfer
I6G45_RS11860	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G45_RS11870	COG1276	copper resistance
I6G45_RS11875	COG2372	response to copper ion
I6G45_RS11885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G45_RS11890	COG1770	oligopeptidase
I6G45_RS11895	COG2979	Protein of unknown function (DUF533)
I6G45_RS11905	COG3141	response to X-ray
I6G45_RS11915	COG0800	Aldolase
I6G45_RS11920	COG0129	dihydroxy-acid dehydratase activity
I6G45_RS11925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6G45_RS11930	COG1737	Transcriptional regulator
I6G45_RS11940	COG1560	Kdo2-lipid A biosynthetic process
I6G45_RS11945	COG0739	heme binding
I6G45_RS11950	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6G45_RS11960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G45_RS11985	COG0494	nUDIX hydrolase
I6G45_RS11995	COG1335	isochorismatase
I6G45_RS12000	COG1801	Protein of unknown function DUF72
I6G45_RS12005	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6G45_RS12015	COG0500	methyltransferase
I6G45_RS12025	COG3142	Participates in the control of copper homeostasis
I6G45_RS12035	COG3102	Protein conserved in bacteria
I6G45_RS12055	COG0494	nUDIX hydrolase
I6G45_RS12080	COG1129	ABC transporter
I6G45_RS12085	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G45_RS12095	COG3539	Fimbrial protein
I6G45_RS12100	COG3121	Chaperone
I6G45_RS12105	COG3188	usher protein
I6G45_RS12120	COG0745	RESPONSE REGULATOR receiver
I6G45_RS12135	COG0840	transmembrane signaling receptor activity
I6G45_RS12150	COG0737	Belongs to the 5'-nucleotidase family
I6G45_RS12155	COG0835	chemotaxis
I6G45_RS12200	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G45_RS12205	COG1129	ABC transporter
I6G45_RS12210	COG1879	ABC-type sugar transport system periplasmic component
I6G45_RS12215	COG1528	Iron-storage protein
I6G45_RS12220	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6G45_RS12225	COG1702	phosphate starvation-inducible protein PhoH
I6G45_RS12230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G45_RS12245	COG1309	transcriptional regulator
I6G45_RS12255	COG3729	General stress protein
I6G45_RS12280	COG2199	diguanylate cyclase activity
I6G45_RS12280	COG2203	Gaf domain
I6G45_RS12285	COG4580	involved in the transport of maltose and maltodextrins
I6G45_RS12290	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6G45_RS12295	COG2723	6-phospho-beta-galactosidase activity
I6G45_RS12300	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G45_RS12300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G45_RS12305	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G45_RS12310	COG1609	Transcriptional regulator
I6G45_RS12325	COG0670	Belongs to the BI1 family
I6G45_RS12335	COG1254	Belongs to the acylphosphatase family
I6G45_RS12350	COG1832	CoA-binding protein
I6G45_RS12355	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I6G45_RS12365	COG0210	DNA helicase
I6G45_RS12370	COG3304	Inner membrane component domain
I6G45_RS12375	COG1289	transmembrane transporter activity
I6G45_RS12380	COG3070	regulator of competence-specific genes
I6G45_RS12390	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6G45_RS12390	COG2885	chlorophyll binding
I6G45_RS12400	COG1067	ATP-dependent peptidase activity
I6G45_RS12410	COG3130	regulation of translation
I6G45_RS12415	COG3009	Protein conserved in bacteria
I6G45_RS12420	COG3008	intermembrane lipid transfer
I6G45_RS12420	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G45_RS12425	COG2995	paraquat-inducible protein a
I6G45_RS12430	COG0488	(ABC) transporter
I6G45_RS12440	COG0633	Ferredoxin
I6G45_RS12440	COG3217	Mosc domain protein beta barrel domain protein
I6G45_RS12455	COG0431	NADPH-dependent FMN reductase
I6G45_RS12460	COG0308	aminopeptidase N
I6G45_RS12475	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G45_RS12480	COG1448	Aminotransferase
I6G45_RS12485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G45_RS12490	COG3108	Peptidase M15
I6G45_RS12495	COG2989	Protein conserved in bacteria
I6G45_RS12505	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6G45_RS12515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G45_RS12520	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6G45_RS12525	COG3173	Aminoglycoside phosphotransferase
I6G45_RS12530	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6G45_RS12535	COG2835	tetraacyldisaccharide 4'-kinase activity
I6G45_RS12540	COG3214	Protein conserved in bacteria
I6G45_RS12555	COG2333	competence protein COMEC
I6G45_RS12555	COG0658	competence protein
I6G45_RS12560	COG0776	regulation of translation
I6G45_RS12565	COG0539	negative regulation of cytoplasmic translation
I6G45_RS12570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6G45_RS12585	COG2323	membrane
I6G45_RS12590	COG1944	ATP diphosphatase activity
I6G45_RS12595	COG2116	formate transmembrane transporter activity
I6G45_RS12600	COG1882	Formate acetyltransferase
I6G45_RS12605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G45_RS12610	COG0477	Major facilitator Superfamily
I6G45_RS12620	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G45_RS12640	COG0492	ferredoxin-NADP+ reductase activity
I6G45_RS12645	COG4988	ABC transporter
I6G45_RS12650	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6G45_RS12665	COG0542	response to heat
I6G45_RS12675	COG1278	Cold shock
I6G45_RS12685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G45_RS12690	COG2990	Protein conserved in bacteria
I6G45_RS12695	COG3593	DNA synthesis involved in DNA repair
I6G45_RS12705	COG2431	L-lysine efflux transmembrane transporter activity
I6G45_RS12710	COG1151	hydroxylamine reductase activity
I6G45_RS12715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G45_RS12725	COG0028	Belongs to the TPP enzyme family
I6G45_RS12730	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6G45_RS12735	COG0702	epimerase
I6G45_RS12740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G45_RS12745	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G45_RS12760	COG1126	abc transporter atp-binding protein
I6G45_RS12765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G45_RS12770	COG4215	(ABC) transporter
I6G45_RS12775	COG4160	amino acid transport
I6G45_RS12780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G45_RS12795	COG1177	transmembrane transport
I6G45_RS12800	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G45_RS12805	COG3842	ATPase activity
I6G45_RS12810	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6G45_RS12825	COG0778	Nitroreductase
I6G45_RS12850	COG3226	Transcriptional regulator
I6G45_RS12855	COG0738	Major facilitator superfamily
I6G45_RS12860	COG0561	phosphatase activity
I6G45_RS12865	COG2814	Major facilitator Superfamily
I6G45_RS12870	COG0671	phosphoesterase, PA-phosphatase related
I6G45_RS12875	COG1349	DNA-binding transcription factor activity
I6G45_RS12880	COG1686	Belongs to the peptidase S11 family
I6G45_RS12885	COG0625	glutathione transferase activity
I6G45_RS12890	COG2133	pyrroloquinoline quinone binding
I6G45_RS12915	COG0747	negative chemotaxis
I6G45_RS12925	COG0303	'Molybdopterin
I6G45_RS12935	COG1609	Transcriptional regulator
I6G45_RS12940	COG2271	Major facilitator Superfamily
I6G45_RS12950	COG2982	Protein involved in outer membrane biogenesis
I6G45_RS12965	COG3447	MASE1 domain protein
I6G45_RS12965	COG5001	Diguanylate cyclase
I6G45_RS12965	COG5002	protein histidine kinase activity
I6G45_RS12970	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6G45_RS12975	COG0443	Heat shock 70 kDa protein
I6G45_RS13010	COG2205	protein histidine kinase activity
I6G45_RS13015	COG0745	RESPONSE REGULATOR receiver
I6G45_RS13025	COG0826	peptidase U32
I6G45_RS13035	COG1830	Aldolase
I6G45_RS13040	COG0351	phosphomethylpyrimidine kinase
I6G45_RS13050	COG1966	Carbon starvation protein
I6G45_RS13055	COG4807	Protein conserved in bacteria
I6G45_RS13065	COG3275	phosphorelay sensor kinase activity
I6G45_RS13075	COG1278	Cold shock
I6G45_RS13080	COG0489	protein tyrosine kinase activity
I6G45_RS13090	COG0789	Transcriptional regulator
I6G45_RS13100	COG1174	glycine betaine transport
I6G45_RS13105	COG1125	glycine betaine transport
I6G45_RS13110	COG1174	glycine betaine transport
I6G45_RS13115	COG1732	Glycine betaine
I6G45_RS13120	COG1472	Belongs to the glycosyl hydrolase 3 family
I6G45_RS13125	COG0277	FAD linked oxidase domain protein
I6G45_RS13135	COG1686	Belongs to the peptidase S11 family
I6G45_RS13145	COG0586	Pfam SNARE associated Golgi protein
I6G45_RS13150	COG1028	Short-chain dehydrogenase reductase Sdr
I6G45_RS13160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G45_RS13170	COG1346	cytolysis
I6G45_RS13180	COG2949	membrane
I6G45_RS13185	COG0628	permease
I6G45_RS13195	COG1129	ABC transporter
I6G45_RS13210	COG2311	Membrane
I6G45_RS13220	COG0477	Major facilitator Superfamily
I6G45_RS13230	COG4771	TonB-dependent receptor
I6G45_RS13235	COG0833	amino acid
I6G45_RS13240	COG0583	DNA-binding transcription factor activity
I6G45_RS13245	COG2855	membrane
I6G45_RS13255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G45_RS13255	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6G45_RS13255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G45_RS13260	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G45_RS13265	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G45_RS13265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G45_RS13270	COG2814	Major facilitator Superfamily
I6G45_RS13285	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6G45_RS13290	COG0246	Mannitol dehydrogenase
I6G45_RS13295	COG0523	cobalamin synthesis protein
I6G45_RS13300	COG0671	phosphoesterase, PA-phosphatase related
I6G45_RS13305	COG0791	NLP P60 protein
I6G45_RS13310	COG2200	EAL domain
I6G45_RS13315	COG4166	transmembrane transport
I6G45_RS13320	COG4174	ABC transporter (Permease)
I6G45_RS13325	COG4239	(ABC) transporter, permease
I6G45_RS13330	COG4172	Belongs to the ABC transporter superfamily
I6G45_RS13340	COG2814	Major facilitator Superfamily
I6G45_RS13345	COG1187	pseudouridine synthase activity
I6G45_RS13350	COG1061	Type III restriction enzyme res subunit
I6G45_RS13440	COG3501	Rhs element vgr protein
I6G45_RS13470	COG2885	chlorophyll binding
I6G45_RS13495	COG2135	peptidase activity
I6G45_RS13515	COG2084	Dehydrogenase
I6G45_RS13520	COG1082	Xylose isomerase domain protein TIM barrel
I6G45_RS13525	COG0149	triose-phosphate isomerase activity
I6G45_RS13530	COG2376	Dihydroxyacetone kinase
I6G45_RS13540	COG0698	ribose 5-phosphate isomerase
I6G45_RS13545	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G45_RS13555	COG0642	Histidine kinase
I6G45_RS13555	COG2198	Histidine kinase
I6G45_RS13570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G45_RS13570	COG2169	Transcriptional regulator
I6G45_RS13575	COG3145	DNA-N1-methyladenine dioxygenase activity
I6G45_RS13580	COG4615	Cyclic peptide transporter
I6G45_RS13585	COG2239	Acts as a magnesium transporter
I6G45_RS13590	COG2205	protein histidine kinase activity
I6G45_RS13590	COG0784	Response regulator, receiver
I6G45_RS13595	COG3852	Histidine kinase
I6G45_RS13600	COG2204	response regulator
I6G45_RS13605	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6G45_RS13610	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G45_RS13615	COG2031	fatty acid transporter
I6G45_RS13620	COG0183	Belongs to the thiolase family
I6G45_RS13635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G45_RS13645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G45_RS13650	COG1028	Short-chain dehydrogenase reductase Sdr
I6G45_RS13665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G45_RS13670	COG1538	Outer membrane efflux protein
I6G45_RS13675	COG0577	efflux transmembrane transporter activity
I6G45_RS13675	COG1136	(ABC) transporter
I6G45_RS13680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G45_RS13685	COG1132	(ABC) transporter
I6G45_RS13725	COG3121	Chaperone
I6G45_RS13735	COG0582	viral genome integration into host DNA
I6G45_RS13740	COG2271	Major facilitator Superfamily
I6G45_RS13745	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G45_RS13755	COG0247	lactate metabolic process
I6G45_RS13785	COG1441	menaquinone biosynthetic process
I6G45_RS13805	COG1169	isochorismate synthase
I6G45_RS13810	COG4575	ribosome binding
I6G45_RS13815	COG2153	protein acetylation
I6G45_RS13830	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G45_RS13835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G45_RS13845	COG0839	Belongs to the complex I subunit 6 family
I6G45_RS13890	COG0583	DNA-binding transcription factor activity
I6G45_RS13895	COG0436	Aminotransferase
I6G45_RS13905	COG0471	metal ion transport
I6G45_RS13905	COG0490	domain, Protein
I6G45_RS13910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G45_RS13940	COG0622	Phosphoesterase
I6G45_RS13945	COG0625	glutathione transferase activity
I6G45_RS13950	COG0625	glutathione transferase activity
I6G45_RS13955	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G45_RS13960	COG1090	epimerase
I6G45_RS13965	COG4598	ABC transporter
I6G45_RS13970	COG4160	amino acid transport
I6G45_RS13980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G45_RS13995	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6G45_RS14000	COG1286	toxin biosynthetic process
I6G45_RS14005	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6G45_RS14010	COG0285	dihydrofolate synthase activity
I6G45_RS14020	COG0586	Pfam SNARE associated Golgi protein
I6G45_RS14030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G45_RS14045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G45_RS14055	COG0523	cobalamin synthesis protein
I6G45_RS14060	COG2879	small protein
I6G45_RS14065	COG1966	Carbon starvation protein
I6G45_RS14075	COG3101	peptidyl-lysine hydroxylation
I6G45_RS14080	COG0730	response to heat
I6G45_RS14105	COG2062	phosphohistidine phosphatase, SixA
I6G45_RS14120	COG3691	Protein conserved in bacteria
I6G45_RS14125	COG2067	long-chain fatty acid transport protein
I6G45_RS14135	COG3088	subunit of a heme lyase
I6G45_RS14135	COG4235	cytochrome complex assembly
I6G45_RS14140	COG4235	cytochrome complex assembly
I6G45_RS14140	COG3088	subunit of a heme lyase
I6G45_RS14145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G45_RS14150	COG1138	Cytochrome C-type biogenesis protein
I6G45_RS14160	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G45_RS14165	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G45_RS14170	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G45_RS14180	COG2116	formate transmembrane transporter activity
I6G45_RS14195	COG0436	Aminotransferase
I6G45_RS14205	COG3275	phosphorelay sensor kinase activity
I6G45_RS14210	COG3279	Response regulator of the LytR AlgR family
I6G45_RS14225	COG3961	Belongs to the TPP enzyme family
I6G45_RS14230	COG0667	Aldo Keto reductase
I6G45_RS14240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G45_RS14240	COG1263	PTS System
I6G45_RS14265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G45_RS14270	COG2199	diguanylate cyclase activity
I6G45_RS14270	COG2200	EAL domain
I6G45_RS14285	COG3415	Transposase
I6G45_RS14290	COG3415	Transposase
I6G45_RS14320	COG0583	DNA-binding transcription factor activity
I6G45_RS14325	COG2211	Major facilitator Superfamily
I6G45_RS14330	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6G45_RS14340	COG0583	DNA-binding transcription factor activity
I6G45_RS14345	COG0385	Bile acid
I6G45_RS14350	COG3530	Putative quorum-sensing-regulated virulence factor
I6G45_RS14375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G45_RS14405	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6G45_RS14410	COG4208	sulfate ABC transporter
I6G45_RS14415	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6G45_RS14420	COG4150	thiosulfate binding
I6G45_RS14425	COG2837	iron assimilation
I6G45_RS14440	COG2076	Multidrug Resistance protein
I6G45_RS14445	COG2076	Multidrug Resistance protein
I6G45_RS14450	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6G45_RS14455	COG0726	polysaccharide deacetylase
I6G45_RS14475	COG3111	PFAM Bacterial OB fold (BOF) protein
I6G45_RS14485	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G45_RS14505	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G45_RS14515	COG5342	invasion associated locus B
I6G45_RS14525	COG3005	denitrification pathway
I6G45_RS14530	COG3043	anaerobic respiration
I6G45_RS14535	COG0348	domain, Protein
I6G45_RS14540	COG0437	4 iron, 4 sulfur cluster binding
I6G45_RS14550	COG3062	negative regulation of establishment of protein localization
I6G45_RS14555	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G45_RS14555	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G45_RS14560	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G45_RS14560	COG0493	'glutamate synthase
I6G45_RS14565	COG3850	Histidine kinase
I6G45_RS14570	COG2197	response regulator
I6G45_RS14575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G45_RS14585	COG1393	Belongs to the ArsC family
I6G45_RS14590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G45_RS14600	COG0400	carboxylic ester hydrolase activity
I6G45_RS14610	COG2321	neutral zinc metallopeptidase
I6G45_RS14620	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6G45_RS14630	COG2716	regulation of RNA biosynthetic process
I6G45_RS14635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G45_RS14640	COG0628	permease
I6G45_RS14645	COG4783	chaperone-mediated protein folding
I6G45_RS14650	COG1393	Belongs to the ArsC family
I6G45_RS14660	COG2233	PERMEase
I6G45_RS14665	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6G45_RS14675	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G45_RS14680	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6G45_RS14690	COG2200	EAL domain
I6G45_RS14705	COG0667	Aldo Keto reductase
I6G45_RS14715	COG3179	chitinase
I6G45_RS14735	COG0517	IMP dehydrogenase activity
I6G45_RS14735	COG0516	GMP reductase activity
I6G45_RS14745	COG1645	bacterial-type flagellum-dependent swarming motility
I6G45_RS14755	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G45_RS14760	COG2976	Protein conserved in bacteria
I6G45_RS14765	COG0124	histidyl-tRNA synthetase
I6G45_RS14790	COG4953	penicillin-binding protein 1C
I6G45_RS14795	COG2373	Large extracellular alpha-helical protein
I6G45_RS14800	COG2897	thiosulfate sulfurtransferase activity
I6G45_RS14815	COG2975	iron-sulfur cluster assembly
I6G45_RS14820	COG0633	Ferredoxin
I6G45_RS14840	COG0822	iron-sulfur transferase activity
I6G45_RS14865	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6G45_RS14875	COG3711	transcriptional antiterminator
I6G45_RS14880	COG2814	Major facilitator Superfamily
I6G45_RS14895	COG1017	nitric oxide dioxygenase activity
I6G45_RS14895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G45_RS14900	COG3264	Mechanosensitive ion channel
I6G45_RS14900	COG1196	nuclear chromosome segregation
I6G45_RS14905	COG1309	transcriptional regulator
I6G45_RS14910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G45_RS14915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G45_RS14935	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G45_RS14945	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6G45_RS14970	COG3695	enzyme binding
I6G45_RS14975	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6G45_RS14980	COG1946	Acyl-CoA thioesterase
I6G45_RS14985	COG0004	ammonium transporteR
I6G45_RS14990	COG0347	Belongs to the P(II) protein family
I6G45_RS14995	COG1132	(ABC) transporter
I6G45_RS15000	COG1132	(ABC) transporter
I6G45_RS15005	COG1522	sequence-specific DNA binding
I6G45_RS15020	COG4533	DNA binding
I6G45_RS15030	COG0824	Thioesterase
I6G45_RS15035	COG1555	photosystem II stabilization
I6G45_RS15040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G45_RS15045	COG0776	regulation of translation
I6G45_RS15050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6G45_RS15070	COG0271	Belongs to the BolA IbaG family
I6G45_RS15075	COG3056	Lipoprotein
I6G45_RS15080	COG2223	nitrite transmembrane transporter activity
I6G45_RS15085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6G45_RS15090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G45_RS15095	COG1845	cytochrome c oxidase, subunit III
I6G45_RS15100	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6G45_RS15110	COG2814	Major facilitator Superfamily
I6G45_RS15120	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G45_RS15135	COG0437	4 iron, 4 sulfur cluster binding
I6G45_RS15140	COG0243	molybdopterin cofactor binding
I6G45_RS15185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G45_RS15200	COG0142	geranyltranstransferase activity
I6G45_RS15210	COG0667	Aldo Keto reductase
I6G45_RS15215	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6G45_RS15230	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G45_RS15230	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G45_RS15240	COG4238	major outer membrane lipoprotein
I6G45_RS15245	COG3248	Nucleoside-binding outer membrane protein
I6G45_RS15255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G45_RS15260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G45_RS15265	COG1862	Preprotein translocase
I6G45_RS15280	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I6G45_RS15285	COG0450	alkyl hydroperoxide reductase
I6G45_RS15300	COG0366	Alpha amylase catalytic
I6G45_RS15315	COG5002	protein histidine kinase activity
I6G45_RS15325	COG0420	3'-5' exonuclease activity
I6G45_RS15330	COG0419	ATPase involved in DNA repair
I6G45_RS15335	COG1940	carbohydrate kinase activity
I6G45_RS15350	COG4126	flavin adenine dinucleotide binding
I6G45_RS15365	COG3416	Protein conserved in bacteria
I6G45_RS15375	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G45_RS15380	COG3706	GGDEF domain
I6G45_RS15405	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G45_RS15425	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6G45_RS15430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G45_RS15435	COG0113	porphobilinogen synthase activity
I6G45_RS15465	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G45_RS15470	COG1464	Belongs to the NlpA lipoprotein family
I6G45_RS15475	COG2011	ABC-type metal ion transport system permease component
I6G45_RS15485	COG0625	glutathione transferase activity
I6G45_RS15495	COG0840	transmembrane signaling receptor activity
I6G45_RS15550	COG1358	cellular component organization or biogenesis
I6G45_RS15575	COG2731	YhcH YjgK YiaL family protein
I6G45_RS15580	COG1737	Transcriptional regulator
I6G45_RS15600	COG0697	spore germination
I6G45_RS15615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6G45_RS15670	COG3706	GGDEF domain
I6G45_RS15685	COG0457	Tetratricopeptide repeat
I6G45_RS15695	COG1649	PFAM Uncharacterised BCR, COG1649
I6G45_RS15695	COG0726	polysaccharide deacetylase
I6G45_RS15700	COG1215	transferase activity, transferring glycosyl groups
I6G45_RS15730	COG2020	methyltransferase activity
I6G45_RS15740	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6G45_RS15795	COG0582	viral genome integration into host DNA
I6G45_RS15800	COG0582	viral genome integration into host DNA
I6G45_RS15850	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6G45_RS15870	COG3596	GTP binding
I6G45_RS15895	COG2003	Belongs to the UPF0758 family
I6G45_RS15950	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G45_RS15965	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G45_RS15970	COG0454	-acetyltransferase
I6G45_RS15980	COG2991	Protein conserved in bacteria
I6G45_RS15995	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G45_RS16000	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G45_RS16015	COG3034	peptidoglycan biosynthetic process
I6G45_RS16020	COG0121	glutamine amidotransferase
I6G45_RS16035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G45_RS16040	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6G45_RS16050	COG1132	(ABC) transporter
I6G45_RS16080	COG2226	methyltransferase
I6G45_RS16090	COG1388	LysM domain
I6G45_RS16090	COG0741	lytic transglycosylase activity
I6G45_RS16095	COG2226	methyltransferase
I6G45_RS16100	COG3021	interspecies interaction between organisms
I6G45_RS16105	COG0583	DNA-binding transcription factor activity
I6G45_RS16135	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6G45_RS16150	COG1464	Belongs to the NlpA lipoprotein family
I6G45_RS16160	COG1720	tRNA m6t6A37 methyltransferase activity
I6G45_RS16170	COG3015	lipoprotein NlpE involved in copper resistance
I6G45_RS16175	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6G45_RS16180	COG4681	YaeQ
I6G45_RS16190	COG4568	rho-dependent transcription termination
I6G45_RS16200	COG0037	tRNA processing
I6G45_RS16210	COG0531	amino acid
I6G45_RS16215	COG3710	Transcriptional regulator
I6G45_RS16220	COG0346	lactoylglutathione lyase activity
I6G45_RS16225	COG1982	Orn Lys Arg decarboxylase major
I6G45_RS16255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G45_RS16260	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G45_RS16265	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6G45_RS16270	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G45_RS16275	COG0750	zinc metalloprotease
I6G45_RS16280	COG0575	Belongs to the CDS family
I6G45_RS16290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6G45_RS16295	COG0233	cytoplasmic translational termination
I6G45_RS16305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6G45_RS16335	COG3835	regulator
I6G45_RS16340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G45_RS16355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G45_RS16360	COG2860	membrane
I6G45_RS16380	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G45_RS16395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G45_RS16400	COG1120	ATPase activity
I6G45_RS16405	COG4774	siderophore transport
I6G45_RS16410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G45_RS16415	COG1643	Atp-dependent helicase
I6G45_RS16420	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6G45_RS16440	COG0617	tRNA 3'-terminal CCA addition
I6G45_RS16445	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6G45_RS16475	COG0726	polysaccharide deacetylase
I6G45_RS16480	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G45_RS16485	COG0842	Transport permease protein
I6G45_RS16490	COG1131	(ABC) transporter
I6G45_RS16495	COG0288	reversible hydration of carbon dioxide
I6G45_RS16500	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6G45_RS16505	COG4993	Dehydrogenase
I6G45_RS16510	COG2132	Multicopper oxidase
I6G45_RS16525	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I6G45_RS16530	COG1349	DNA-binding transcription factor activity
I6G45_RS16565	COG3064	Membrane
I6G45_RS16580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G45_RS16585	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G45_RS16590	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6G45_RS16595	COG2186	Transcriptional regulator
I6G45_RS16600	COG1113	amino acid transport
I6G45_RS16605	COG2211	Major facilitator Superfamily
I6G45_RS16610	COG3940	Belongs to the glycosyl hydrolase 43 family
I6G45_RS16615	COG3725	Membrane protein required for beta-lactamase induction
I6G45_RS16630	COG4969	Belongs to the N-Me-Phe pilin family
I6G45_RS16635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G45_RS16640	COG1459	type II secretion system
I6G45_RS16645	COG0516	GMP reductase activity
I6G45_RS16650	COG0237	dephospho-CoA kinase activity
I6G45_RS16665	COG0494	nUDIX hydrolase
I6G45_RS16675	COG3171	Protein conserved in bacteria
I6G45_RS16685	COG1194	a g-specific adenine glycosylase
I6G45_RS16695	COG0741	lytic transglycosylase activity
I6G45_RS16700	COG2211	Major facilitator Superfamily
I6G45_RS16705	COG1982	Orn Lys Arg decarboxylase major
I6G45_RS16710	COG1811	Na channel or pump
I6G45_RS16725	COG3647	Membrane
I6G45_RS16730	COG3647	Membrane
I6G45_RS16755	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G45_RS16760	COG0625	glutathione transferase activity
I6G45_RS16770	COG2862	Uncharacterized protein family, UPF0114
I6G45_RS16790	COG1028	Short-chain dehydrogenase reductase Sdr
I6G45_RS16795	COG0848	biopolymer transport protein
I6G45_RS16810	COG0586	Pfam SNARE associated Golgi protein
I6G45_RS16815	COG2207	Transcriptional regulator
I6G45_RS16820	COG1979	alcohol dehydrogenase
I6G45_RS16830	COG0471	metal ion transport
I6G45_RS16835	COG1032	radical SAM domain protein
I6G45_RS16840	COG2132	Multicopper oxidase
I6G45_RS16855	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G45_RS16860	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6G45_RS16870	COG3150	esterase
I6G45_RS16875	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6G45_RS16880	COG3151	Protein conserved in bacteria
I6G45_RS16885	COG0494	nUDIX hydrolase
I6G45_RS16890	COG1538	Outer membrane efflux protein
I6G45_RS16900	COG0754	glutathionylspermidine amidase activity
I6G45_RS16905	COG3384	dioxygenase
I6G45_RS16935	COG3025	triphosphatase activity
I6G45_RS16940	COG4991	sh3 domain protein
I6G45_RS16950	COG1968	undecaprenyl-diphosphatase activity
I6G45_RS16955	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G45_RS16975	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6G45_RS16980	COG0358	DNA primase activity
I6G45_RS17030	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6G45_RS17040	COG0732	type I restriction modification DNA specificity domain
I6G45_RS17045	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6G45_RS17115	COG1401	restriction endodeoxyribonuclease activity
I6G45_RS17155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G45_RS17160	COG1120	ATPase activity
I6G45_RS17190	COG2972	Histidine kinase
I6G45_RS17190	COG0745	RESPONSE REGULATOR receiver
I6G45_RS17195	COG2207	Transcriptional regulator
I6G45_RS17200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6G45_RS17215	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G45_RS17220	COG1882	Formate acetyltransferase
I6G45_RS17225	COG0693	protein deglycase activity
I6G45_RS17235	COG1012	belongs to the aldehyde dehydrogenase family
I6G45_RS17275	COG4869	propanediol catabolic process
I6G45_RS17285	COG3842	ATPase activity
I6G45_RS17295	COG1840	ABC-type Fe3 transport system, periplasmic component
I6G45_RS17300	COG2271	Major facilitator Superfamily
I6G45_RS17315	COG2375	cellular response to nickel ion
I6G45_RS17320	COG1695	Transcriptional regulator
I6G45_RS17325	COG0840	transmembrane signaling receptor activity
I6G45_RS17345	COG0560	Phosphoserine phosphatase
I6G45_RS17350	COG3726	membrane protein affecting hemolysin expression
I6G45_RS17385	COG3157	Type VI secretion system effector, Hcp
I6G45_RS17390	COG0095	Lipoate-protein ligase
I6G45_RS17395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G45_RS17420	COG1328	CTP reductase activity
I6G45_RS17425	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G45_RS17430	COG0084	hydrolase, TatD family'
I6G45_RS17435	COG4667	esterase of the alpha-beta hydrolase superfamily
I6G45_RS17445	COG2823	Periplasmic or secreted lipoprotein
I6G45_RS17455	COG1011	Hydrolase
I6G45_RS17460	COG0456	acetyltransferase
I6G45_RS17465	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6G45_RS17495	COG3706	GGDEF domain
I6G45_RS17500	COG4114	ferric iron reductase
I6G45_RS17505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G45_RS17510	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G45_RS17515	COG2197	response regulator
I6G45_RS17520	COG2197	response regulator
I6G45_RS17525	COG2966	Psort location CytoplasmicMembrane, score
I6G45_RS17540	COG1484	DNA-dependent DNA replication
I6G45_RS17560	COG1902	pentaerythritol trinitrate reductase activity
I6G45_RS17560	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G45_RS17570	COG1451	nucleotide metabolic process
I6G45_RS17575	COG0673	inositol 2-dehydrogenase activity
I6G45_RS17580	COG0861	Integral membrane protein TerC family
I6G45_RS17585	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6G45_RS17595	COG2721	sulfolactate sulfo-lyase activity
I6G45_RS17605	COG2271	Major facilitator Superfamily
I6G45_RS17610	COG2186	Transcriptional regulator
I6G45_RS17615	COG0586	Pfam SNARE associated Golgi protein
I6G45_RS17625	COG1422	Protein of unknown function (DUF1090)
I6G45_RS17630	COG4575	ribosome binding
I6G45_RS17635	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6G45_RS17645	COG2259	Doxx family
I6G45_RS17650	COG0435	Glutathione S-transferase
I6G45_RS17655	COG3152	Membrane
I6G45_RS17660	COG0583	DNA-binding transcription factor activity
I6G45_RS17665	COG1741	Belongs to the pirin family
I6G45_RS17675	COG2850	peptidyl-arginine hydroxylation
I6G45_RS17680	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6G45_RS17685	COG1830	Aldolase
I6G45_RS17700	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G45_RS17705	COG1129	ABC transporter
I6G45_RS17715	COG1070	Carbohydrate kinase
I6G45_RS17720	COG0840	transmembrane signaling receptor activity
I6G45_RS17740	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6G45_RS17745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G45_RS17750	COG2222	sugar isomerase
I6G45_RS17755	COG2188	Transcriptional regulator
I6G45_RS17775	COG0589	response to stress
I6G45_RS17780	COG2733	membrane
I6G45_RS17790	COG0477	Major facilitator Superfamily
I6G45_RS17805	COG0477	Major facilitator Superfamily
I6G45_RS17810	COG4948	Mandelate Racemase Muconate Lactonizing
I6G45_RS17815	COG1028	Short-chain dehydrogenase reductase Sdr
I6G45_RS17820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G45_RS17880	COG0795	lipopolysaccharide-transporting ATPase activity
I6G45_RS17885	COG0795	lipopolysaccharide-transporting ATPase activity
I6G45_RS17895	COG2927	DNA polymerase III (CHI subunit)
I6G45_RS17900	COG0525	valine-tRNA ligase activity
I6G45_RS17930	COG2731	YhcH YjgK YiaL family protein
I6G45_RS17955	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6G45_RS17960	COG1609	Transcriptional regulator
I6G45_RS17965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G45_RS17965	COG1263	PTS System
I6G45_RS17970	COG0366	Alpha amylase catalytic
I6G45_RS17985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G45_RS17985	COG3711	transcriptional antiterminator
I6G45_RS18000	COG3964	amidohydrolase
I6G45_RS18035	COG0312	modulator of DNA gyrase
I6G45_RS18045	COG2969	positive regulation of protein catabolic process
I6G45_RS18050	COG0625	glutathione transferase activity
I6G45_RS18065	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6G45_RS18070	COG3105	Protein conserved in bacteria
I6G45_RS18075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G45_RS18080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G45_RS18105	COG2732	(Barnase) inhibitor
I6G45_RS18110	COG1012	belongs to the aldehyde dehydrogenase family
I6G45_RS18115	COG1289	transmembrane transporter activity
I6G45_RS18130	COG0583	DNA-binding transcription factor activity
I6G45_RS18135	COG0312	modulator of DNA gyrase
I6G45_RS18140	COG3164	Protein of unknown function
I6G45_RS18155	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6G45_RS18160	COG1792	Involved in formation and maintenance of cell shape
I6G45_RS18165	COG1077	Cell shape determining protein MreB Mrl
I6G45_RS18170	COG2199	diguanylate cyclase activity
I6G45_RS18170	COG2200	EAL domain
I6G45_RS18175	COG0604	alcohol dehydrogenase
I6G45_RS18185	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6G45_RS18195	COG0511	ligase activity, forming carbon-carbon bonds
I6G45_RS18200	COG0439	Biotin carboxylase
I6G45_RS18205	COG3924	membrane
I6G45_RS18210	COG4145	pantothenate transmembrane transporter activity
I6G45_RS18235	COG1309	transcriptional regulator
I6G45_RS18240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G45_RS18245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G45_RS18255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G45_RS18260	COG4597	amino acid ABC transporter
I6G45_RS18265	COG0765	amino acid transport
I6G45_RS18270	COG1126	abc transporter atp-binding protein
I6G45_RS18310	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G45_RS18330	COG0551	DNA topoisomerase type I activity
I6G45_RS18340	COG0758	DNA mediated transformation
I6G45_RS18370	COG3036	rescue of stalled ribosome
I6G45_RS18375	COG0789	Transcriptional regulator
I6G45_RS18385	COG0203	ribosomal protein L17
I6G45_RS18415	COG0201	protein transport
I6G45_RS18420	COG0200	Binds to the 23S rRNA
I6G45_RS18425	COG1841	ribosomal large subunit assembly
I6G45_RS18430	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6G45_RS18435	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6G45_RS18465	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6G45_RS18480	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6G45_RS18495	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6G45_RS18520	COG0051	transcription antitermination factor activity, RNA binding
I6G45_RS18570	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6G45_RS18575	COG2964	Protein conserved in bacteria
I6G45_RS18580	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G45_RS18590	COG1047	Peptidyl-prolyl cis-trans
I6G45_RS18595	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6G45_RS18600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G45_RS18600	COG0475	glutathione-regulated potassium exporter activity
I6G45_RS18605	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G45_RS18610	COG0488	(ABC) transporter
I6G45_RS18620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G45_RS18630	COG0429	hydrolase of the alpha beta-hydrolase fold
I6G45_RS18640	COG3954	Phosphoribulokinase
I6G45_RS18645	COG1765	OsmC-like protein
I6G45_RS18655	COG1289	transmembrane transporter activity
I6G45_RS18660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G45_RS18665	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G45_RS18690	COG0402	S-adenosylhomocysteine deaminase activity
I6G45_RS18695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G45_RS18700	COG2146	nitrite reductase [NAD(P)H] activity
I6G45_RS18715	COG0531	amino acid
I6G45_RS18720	COG2222	sugar isomerase
I6G45_RS18725	COG1082	Xylose isomerase domain protein TIM barrel
I6G45_RS18730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G45_RS18735	COG2188	Transcriptional regulator
I6G45_RS18740	COG0180	Tryptophanyl-tRNA synthetase
I6G45_RS18750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G45_RS18755	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6G45_RS18760	COG3266	domain, Protein
I6G45_RS18770	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6G45_RS18775	COG4796	Type ii and iii secretion system protein
I6G45_RS18795	COG4972	Pilus assembly protein
I6G45_RS18800	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6G45_RS18805	COG0494	nUDIX hydrolase
I6G45_RS18815	COG1011	Hydrolase
I6G45_RS18820	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6G45_RS18850	COG0246	Mannitol dehydrogenase
I6G45_RS18855	COG2186	Transcriptional regulator
I6G45_RS18860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G45_RS18865	COG2183	response to ionizing radiation
I6G45_RS18870	COG1918	ferrous iron import across plasma membrane
I6G45_RS18895	COG1040	competence protein
I6G45_RS18905	COG1640	4-alpha-glucanotransferase
I6G45_RS18910	COG0058	SHG alpha-glucan phosphorylase activity
I6G45_RS18920	COG1349	DNA-binding transcription factor activity
I6G45_RS18930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G45_RS18935	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G45_RS18940	COG0058	SHG alpha-glucan phosphorylase activity
I6G45_RS18950	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6G45_RS18970	COG2095	MarC family integral membrane protein
I6G45_RS18975	COG2610	gluconate transmembrane transporter activity
I6G45_RS18980	COG3265	gluconokinase activity
I6G45_RS18985	COG1609	Transcriptional regulator
I6G45_RS18990	COG1741	Belongs to the pirin family
I6G45_RS18995	COG1247	-acetyltransferase
I6G45_RS19005	COG0840	transmembrane signaling receptor activity
I6G45_RS19010	COG0405	Gamma-glutamyltransferase
I6G45_RS19020	COG0584	glycerophosphoryl diester phosphodiesterase
I6G45_RS19055	COG0410	ABC transporter
I6G45_RS19065	COG4177	L-phenylalanine transmembrane transporter activity
I6G45_RS19075	COG0683	leucine binding
I6G45_RS19085	COG0683	leucine binding
I6G45_RS19090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G45_RS19095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G45_RS19100	COG2177	Part of the ABC transporter FtsEX involved in
I6G45_RS19105	COG2884	Cell division ATP-binding protein ftsE
I6G45_RS19110	COG0552	protein localization to endoplasmic reticulum
I6G45_RS19115	COG0742	ribosomal rna small subunit methyltransferase
I6G45_RS19120	COG3776	membrane
I6G45_RS19130	COG3714	YhhN family
I6G45_RS19150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6G45_RS19160	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6G45_RS19185	COG0628	permease
I6G45_RS19215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G45_RS19260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G45_RS19270	COG1028	Short-chain dehydrogenase reductase Sdr
I6G45_RS19280	COG2091	lysine biosynthetic process via aminoadipic acid
I6G45_RS19285	COG0791	NLP P60 protein
I6G45_RS19295	COG1028	Short-chain dehydrogenase reductase Sdr
I6G45_RS19300	COG3387	PFAM Glycoside hydrolase 15-related
I6G45_RS19305	COG2200	EAL domain
I6G45_RS19345	COG0437	4 iron, 4 sulfur cluster binding
I6G45_RS19350	COG2864	formate dehydrogenase
I6G45_RS19360	COG2205	protein histidine kinase activity
I6G45_RS19365	COG0745	RESPONSE REGULATOR receiver
I6G45_RS19370	COG1276	copper resistance
I6G45_RS19375	COG2372	response to copper ion
I6G45_RS19380	COG3667	copper resistance
I6G45_RS19385	COG2132	Multicopper oxidase
I6G45_RS19395	COG0739	heme binding
I6G45_RS19425	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G45_RS19500	COG2081	HI0933 family
I6G45_RS19505	COG0306	phosphate transporter
I6G45_RS19515	COG0589	response to stress
I6G45_RS19525	COG0477	Major facilitator Superfamily
I6G45_RS19530	COG1295	ribonuclease BN
I6G45_RS19535	COG0583	DNA-binding transcription factor activity
I6G45_RS19540	COG1028	Short-chain dehydrogenase reductase Sdr
I6G45_RS19545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G45_RS19555	COG3191	aminopeptidase activity
I6G45_RS19560	COG0740	serine-type endopeptidase activity
I6G45_RS19575	COG3713	MltA-interacting MipA family protein
I6G45_RS19590	COG3685	Protein conserved in bacteria
I6G45_RS19595	COG3546	catalase activity
I6G45_RS19600	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6G45_RS19605	COG1924	4 iron, 4 sulfur cluster binding
I6G45_RS19615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G45_RS19620	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6G45_RS19640	COG2200	EAL domain
I6G45_RS19645	COG2982	Protein involved in outer membrane biogenesis
I6G45_RS19650	COG0612	Peptidase, M16
I6G45_RS19660	COG2199	diguanylate cyclase activity
I6G45_RS19660	COG2200	EAL domain
I6G45_RS19665	COG0457	Tetratricopeptide repeat
I6G45_RS19670	COG0726	polysaccharide deacetylase
I6G45_RS19670	COG1649	PFAM Uncharacterised BCR, COG1649
I6G45_RS19675	COG1215	transferase activity, transferring glycosyl groups
I6G45_RS19680	COG3658	cytochrome
I6G45_RS19700	COG4608	Belongs to the ABC transporter superfamily
I6G45_RS19705	COG0444	Belongs to the ABC transporter superfamily
I6G45_RS19710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G45_RS19715	COG0601	transmembrane transport
I6G45_RS19720	COG0747	negative chemotaxis
I6G45_RS19725	COG0583	DNA-binding transcription factor activity
I6G45_RS19735	COG1335	isochorismatase
I6G45_RS19740	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6G45_RS19745	COG1304	FMN binding
I6G45_RS19750	COG0549	Belongs to the carbamate kinase family
I6G45_RS19765	COG5001	Diguanylate cyclase
I6G45_RS19765	COG4251	negative regulation of phosphorylation
I6G45_RS19765	COG3706	GGDEF domain
I6G45_RS19765	COG2203	Gaf domain
I6G45_RS19810	COG2194	sulfuric ester hydrolase activity
I6G45_RS19815	COG2223	nitrite transmembrane transporter activity
I6G45_RS19820	COG5571	outer membrane autotransporter
I6G45_RS19825	COG2818	Glycosylase
I6G45_RS19830	COG0456	acetyltransferase
I6G45_RS19835	COG0243	molybdopterin cofactor binding
I6G45_RS19840	COG2885	chlorophyll binding
I6G45_RS19845	COG1609	Transcriptional regulator
I6G45_RS19855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G45_RS19870	COG0738	Major facilitator superfamily
I6G45_RS19880	COG1486	melibiose metabolic process
I6G45_RS19885	COG1263	PTS System
I6G45_RS19885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G45_RS19905	COG3842	ATPase activity
I6G45_RS19925	COG2944	sequence-specific DNA binding
I6G45_RS19950	COG3274	enterobacterial common antigen metabolic process
I6G45_RS19965	COG1070	Carbohydrate kinase
I6G45_RS19970	COG2115	Belongs to the xylose isomerase family
I6G45_RS19975	COG4213	ABC transporter substrate-binding protein
I6G45_RS19985	COG4214	carbohydrate transport
I6G45_RS19990	COG2207	Transcriptional regulator
I6G45_RS19990	COG1609	Transcriptional regulator
I6G45_RS19995	COG2992	FlgJ-related protein
I6G45_RS20000	COG0366	Alpha amylase catalytic
I6G45_RS20005	COG3977	Valine--pyruvate aminotransferase
I6G45_RS20010	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G45_RS20015	COG1940	carbohydrate kinase activity
I6G45_RS20020	COG1454	alcohol dehydrogenase
I6G45_RS20025	COG3276	selenocysteine insertion sequence binding
I6G45_RS20035	COG0625	glutathione transferase activity
I6G45_RS20040	COG2213	PTS system mannitol-specific
I6G45_RS20040	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G45_RS20050	COG3722	fumarate hydratase activity
I6G45_RS20065	COG2186	Transcriptional regulator
I6G45_RS20075	COG2258	MOSC domain
I6G45_RS20080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G45_RS20115	COG1454	alcohol dehydrogenase
I6G45_RS20130	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6G45_RS20155	COG0437	4 iron, 4 sulfur cluster binding
I6G45_RS20160	COG2864	formate dehydrogenase
I6G45_RS20210	COG5001	Diguanylate cyclase
I6G45_RS20225	COG3685	Protein conserved in bacteria
I6G45_RS20230	COG3729	General stress protein
I6G45_RS20245	COG0765	amino acid transport
I6G45_RS20250	COG0765	amino acid transport
I6G45_RS20260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G45_RS20270	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6G45_RS20275	COG0437	4 iron, 4 sulfur cluster binding
I6G45_RS20280	COG3301	Polysulphide reductase, NrfD
I6G45_RS20285	COG1138	Cytochrome C-type biogenesis protein
I6G45_RS20290	COG4235	cytochrome complex assembly
I6G45_RS20295	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6G45_RS20305	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6G45_RS20310	COG0437	4 iron, 4 sulfur cluster binding
I6G45_RS20315	COG5557	Pfam Polysulphide reductase, NrfD
I6G45_RS20320	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6G45_RS20325	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6G45_RS20330	COG1773	rubredoxin
I6G45_RS20335	COG0298	carbon dioxide binding
I6G45_RS20340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6G45_RS20345	COG0440	acetolactate synthase activity
I6G45_RS20350	COG0028	Belongs to the TPP enzyme family
I6G45_RS20370	COG2814	Major facilitator Superfamily
I6G45_RS20380	COG2149	membrane
I6G45_RS20390	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G45_RS20400	COG5645	(Lipo)protein
I6G45_RS20405	COG0823	Involved in the tonB-independent uptake of proteins
I6G45_RS20410	COG2271	Major facilitator Superfamily
I6G45_RS20420	COG0800	Aldolase
I6G45_RS20425	COG3734	2-keto-3-deoxy-galactonokinase
I6G45_RS20430	COG2186	Transcriptional regulator
I6G45_RS20435	COG0561	phosphatase activity
I6G45_RS20450	COG0592	DNA-directed DNA polymerase activity
I6G45_RS20470	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6G45_RS20475	COG0706	membrane insertase activity
I6G45_RS20490	COG2091	lysine biosynthetic process via aminoadipic acid
I6G45_RS20495	COG0431	NADPH-dependent FMN reductase
I6G45_RS20500	COG2252	PERMEase
I6G45_RS20505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G45_RS20510	COG0704	Plays a role in the regulation of phosphate uptake
I6G45_RS20515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G45_RS20520	COG0581	inorganic phosphate transmembrane transporter activity
I6G45_RS20525	COG0573	inorganic phosphate transmembrane transporter activity
I6G45_RS20530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6G45_RS20550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6G45_RS20570	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6G45_RS20585	COG3312	ion transport
I6G45_RS20600	COG0716	FMN binding
I6G45_RS20605	COG1522	sequence-specific DNA binding
I6G45_RS20630	COG1869	D-ribose catabolic process
I6G45_RS20635	COG1129	ABC transporter
I6G45_RS20640	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G45_RS20650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G45_RS20655	COG1609	Transcriptional regulator
I6G45_RS20660	COG0477	Major facilitator Superfamily
I6G45_RS20665	COG2186	Transcriptional regulator
I6G45_RS20690	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6G45_RS20695	COG0746	molybdenum cofactor guanylyltransferase activity
I6G45_RS20700	COG3084	Protein conserved in bacteria
I6G45_RS20705	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6G45_RS20715	COG0204	Acyl-transferase
I6G45_RS20730	COG3078	GTPase activator activity
I6G45_RS20735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G45_RS20750	COG3852	Histidine kinase
I6G45_RS20765	COG1349	DNA-binding transcription factor activity
I6G45_RS20770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G45_RS20780	COG3684	Belongs to the aldolase LacD family
I6G45_RS20785	COG1063	alcohol dehydrogenase
I6G45_RS20795	COG0477	Major facilitator Superfamily
I6G45_RS20805	COG1011	Hydrolase
I6G45_RS20815	COG1490	D-aminoacyl-tRNA deacylase activity
I6G45_RS20820	COG0456	acetyltransferase
I6G45_RS20825	COG2982	Protein involved in outer membrane biogenesis
I6G45_RS20830	COG2233	PERMEase
I6G45_RS20870	COG3539	Fimbrial protein
I6G45_RS20875	COG3188	usher protein
I6G45_RS20880	COG3121	Chaperone
I6G45_RS20890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G45_RS20895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G45_RS20900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G45_RS20905	COG1758	RNA polymerase activity
I6G45_RS20910	COG0194	GDP metabolic process
I6G45_RS20915	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6G45_RS20920	COG2860	membrane
I6G45_RS20925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G45_RS21015	COG1561	YicC-like family, N-terminal region
I6G45_RS21040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G45_RS21045	COG2003	Belongs to the UPF0758 family
I6G45_RS21050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6G45_RS21070	COG1519	Transferase
I6G45_RS21075	COG0859	PFAM glycosyl transferase family 9
I6G45_RS21080	COG0438	transferase activity, transferring glycosyl groups
I6G45_RS21085	COG0515	serine threonine protein kinase
I6G45_RS21115	COG0859	PFAM glycosyl transferase family 9
I6G45_RS21130	COG0156	8-amino-7-oxononanoate synthase activity
I6G45_RS21135	COG1063	alcohol dehydrogenase
I6G45_RS21140	COG1216	Glycosyl transferase, family 2
I6G45_RS21145	COG2861	carbohydrate metabolic process
I6G45_RS21150	COG4942	peptidase
I6G45_RS21160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G45_RS21165	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6G45_RS21185	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6G45_RS21190	COG2205	protein histidine kinase activity
I6G45_RS21195	COG0745	RESPONSE REGULATOR receiver
I6G45_RS21200	COG3678	ATP-independent chaperone mediated protein folding
I6G45_RS21230	COG2211	Major facilitator Superfamily
I6G45_RS21235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G45_RS21245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G45_RS21255	COG0149	triose-phosphate isomerase activity
I6G45_RS21265	COG3152	Membrane
I6G45_RS21275	COG1494	fructose-1,6-bisphosphatase
I6G45_RS21285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G45_RS21295	COG1464	Belongs to the NlpA lipoprotein family
I6G45_RS21300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G45_RS21305	COG1575	Belongs to the MenA family. Type 1 subfamily
I6G45_RS21315	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6G45_RS21320	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6G45_RS21325	COG1609	Transcriptional regulator