locus-tag	class	description
APAR_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APAR_RS00020	COG0592	DNA-directed DNA polymerase activity
APAR_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APAR_RS00035	COG0187	DNA topoisomerase II activity
APAR_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APAR_RS00070	COG3842	ATPase activity
APAR_RS00075	COG1609	Transcriptional regulator
APAR_RS00080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APAR_RS00085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APAR_RS00100	COG1217	gtp-binding protein TYPA
APAR_RS00105	COG2860	membrane
APAR_RS00125	COG0360	Binds together with S18 to 16S ribosomal RNA
APAR_RS00130	COG0629	single-stranded DNA binding
APAR_RS00135	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APAR_RS00145	COG0359	binds to the 23S rRNA
APAR_RS00155	COG0305	Participates in initiation and elongation during chromosome replication
APAR_RS00160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APAR_RS00170	COG0494	nUDIX hydrolase
APAR_RS00175	COG1132	(ABC) transporter
APAR_RS00185	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
APAR_RS00190	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APAR_RS00195	COG4509	Sortase family
APAR_RS00200	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APAR_RS00205	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APAR_RS00210	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APAR_RS00230	COG0300	oxidoreductase activity
APAR_RS00245	COG0306	phosphate transporter
APAR_RS00295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APAR_RS00300	COG0039	L-malate dehydrogenase activity
APAR_RS00315	COG1131	(ABC) transporter
APAR_RS00325	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APAR_RS00330	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APAR_RS00335	COG0371	Dehydrogenase
APAR_RS00345	COG0426	domain, Protein
APAR_RS00375	COG2239	Acts as a magnesium transporter
APAR_RS00380	COG1704	LemA family
APAR_RS00390	COG0590	tRNA wobble adenosine to inosine editing
APAR_RS00395	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
APAR_RS00405	COG0513	Belongs to the DEAD box helicase family
APAR_RS00415	COG0622	Phosphoesterase
APAR_RS00420	COG2188	Transcriptional regulator
APAR_RS00425	COG2723	6-phospho-beta-galactosidase activity
APAR_RS00430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APAR_RS00435	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APAR_RS00440	COG1447	Phosphotransferase system cellobiose-specific component IIA
APAR_RS00450	COG2502	aspartate--ammonia ligase
APAR_RS00455	COG0783	Belongs to the Dps family
APAR_RS00465	COG0348	domain, Protein
APAR_RS00475	COG0745	RESPONSE REGULATOR receiver
APAR_RS00480	COG2205	protein histidine kinase activity
APAR_RS00495	COG0443	Heat shock 70 kDa protein
APAR_RS00505	COG0484	heat shock protein binding
APAR_RS00510	COG0789	Transcriptional regulator
APAR_RS00525	COG0542	response to heat
APAR_RS00535	COG3250	beta-galactosidase activity
APAR_RS00555	COG0037	tRNA processing
APAR_RS00560	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
APAR_RS00565	COG0436	Aminotransferase
APAR_RS00570	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
APAR_RS00575	COG0708	Exodeoxyribonuclease III
APAR_RS00590	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
APAR_RS00595	COG0254	rRNA binding
APAR_RS00600	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APAR_RS00605	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APAR_RS00610	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APAR_RS00630	COG1959	2 iron, 2 sulfur cluster binding
APAR_RS00635	COG1194	a g-specific adenine glycosylase
APAR_RS00640	COG1592	Rubrerythrin
APAR_RS00645	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APAR_RS00650	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APAR_RS00660	COG3956	TIGRFAM MazG family protein
APAR_RS00670	COG0248	Ppx GppA phosphatase
APAR_RS00670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APAR_RS00690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APAR_RS00715	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
APAR_RS00720	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APAR_RS00725	COG1328	CTP reductase activity
APAR_RS00740	COG1522	sequence-specific DNA binding
APAR_RS00740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APAR_RS00745	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
APAR_RS00750	COG0813	purine-nucleoside phosphorylase activity
APAR_RS00755	COG1744	ABC transporter substrate-binding protein PnrA-like
APAR_RS00760	COG3845	ABC transporter
APAR_RS00765	COG4603	Belongs to the binding-protein-dependent transport system permease family
APAR_RS00770	COG1079	Belongs to the binding-protein-dependent transport system permease family
APAR_RS00775	COG0295	cytidine deaminase activity
APAR_RS00780	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
APAR_RS00800	COG3414	Phosphotransferase system galactitol-specific IIB component
APAR_RS00805	COG3775	system Galactitol-specific IIC component
APAR_RS00820	COG2195	Cleaves the N-terminal amino acid of tripeptides
APAR_RS00835	COG0561	phosphatase activity
APAR_RS00860	COG0644	oxidoreductase
APAR_RS00870	COG0577	efflux transmembrane transporter activity
APAR_RS00880	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APAR_RS00885	COG0363	glucosamine-6-phosphate deaminase activity
APAR_RS00890	COG4466	Protein conserved in bacteria
APAR_RS00895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APAR_RS00915	COG3959	Transketolase, thiamine diphosphate binding domain
APAR_RS00920	COG3958	Transketolase
APAR_RS00925	COG1250	3-hydroxyacyl-CoA dehydrogenase
APAR_RS00935	COG1002	Type II restriction enzyme, methylase subunits
APAR_RS00970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APAR_RS00975	COG0459	protein refolding
APAR_RS00990	COG1316	TRANSCRIPTIONal
APAR_RS00995	COG1388	LysM domain
APAR_RS00995	COG4932	domain protein
APAR_RS01000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APAR_RS01000	COG0519	Catalyzes the synthesis of GMP from XMP
APAR_RS01020	COG1196	nuclear chromosome segregation
APAR_RS01055	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APAR_RS01095	COG3177	Filamentation induced by cAMP protein fic
APAR_RS01115	COG0488	(ABC) transporter
APAR_RS01145	COG1131	(ABC) transporter
APAR_RS01175	COG3041	Addiction module toxin RelE StbE family
APAR_RS01180	COG1959	2 iron, 2 sulfur cluster binding
APAR_RS01190	COG1335	isochorismatase
APAR_RS01205	COG1136	(ABC) transporter
APAR_RS01210	COG1136	(ABC) transporter
APAR_RS01210	COG0577	efflux transmembrane transporter activity
APAR_RS01240	COG0402	S-adenosylhomocysteine deaminase activity
APAR_RS01245	COG0493	'glutamate synthase
APAR_RS01245	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APAR_RS01260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APAR_RS01265	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APAR_RS01270	COG0549	Belongs to the carbamate kinase family
APAR_RS01275	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APAR_RS01275	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APAR_RS01285	COG0251	oxidation-reduction process
APAR_RS01295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APAR_RS01305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APAR_RS01315	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APAR_RS01315	COG3608	succinylglutamate desuccinylase aspartoacylase
APAR_RS01320	COG0709	Synthesizes selenophosphate from selenide and ATP
APAR_RS01325	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APAR_RS01325	COG3608	succinylglutamate desuccinylase aspartoacylase
APAR_RS01335	COG4149	molybdate abc transporter
APAR_RS01340	COG3842	ATPase activity
APAR_RS01365	COG0521	Mo-molybdopterin cofactor biosynthetic process
APAR_RS01375	COG3976	FMN-binding domain protein
APAR_RS01375	COG1053	succinate dehydrogenase
APAR_RS01375	COG0431	NADPH-dependent FMN reductase
APAR_RS01395	COG1418	mRNA catabolic process
APAR_RS01400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APAR_RS01420	COG4988	ABC transporter
APAR_RS01425	COG1132	(ABC) transporter
APAR_RS01455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APAR_RS01460	COG1121	(ABC) transporter
APAR_RS01465	COG0803	Belongs to the bacterial solute-binding protein 9 family
APAR_RS01470	COG1028	Short-chain dehydrogenase reductase Sdr
APAR_RS01500	COG0584	glycerophosphoryl diester phosphodiesterase
APAR_RS01505	COG2217	Heavy metal translocating P-type atpase
APAR_RS01510	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APAR_RS01515	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
APAR_RS01520	COG0402	S-adenosylhomocysteine deaminase activity
APAR_RS01525	COG0523	cobalamin synthesis protein
APAR_RS01530	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APAR_RS01545	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APAR_RS01545	COG2755	lipolytic protein G-D-S-L family
APAR_RS01560	COG1528	Iron-storage protein
APAR_RS01570	COG0252	asparaginase activity
APAR_RS01585	COG4868	Belongs to the UPF0371 family
APAR_RS01625	COG1482	cell wall glycoprotein biosynthetic process
APAR_RS01635	COG1970	mechanosensitive ion channel activity
APAR_RS01640	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
APAR_RS01645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APAR_RS01650	COG1181	Belongs to the D-alanine--D-alanine ligase family
APAR_RS01660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APAR_RS01660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APAR_RS01660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APAR_RS01670	COG0217	transcriptional regulatory protein
APAR_RS01675	COG1349	DNA-binding transcription factor activity
APAR_RS01685	COG3037	sugar-specific permease SgaT UlaA
APAR_RS01710	COG3623	hexulose-6-phosphate isomerase
APAR_RS01715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APAR_RS01720	COG3959	Transketolase, thiamine diphosphate binding domain
APAR_RS01725	COG3958	Transketolase
APAR_RS01735	COG1132	(ABC) transporter
APAR_RS01740	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APAR_RS01740	COG0493	'glutamate synthase
APAR_RS01745	COG0543	2 iron, 2 sulfur cluster binding
APAR_RS01750	COG0193	aminoacyl-tRNA hydrolase activity
APAR_RS01755	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
APAR_RS01765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APAR_RS01770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APAR_RS01780	COG3773	Cell wall hydrolase
APAR_RS01780	COG3409	Peptidoglycan-binding domain 1 protein
APAR_RS01785	COG0142	geranyltranstransferase activity
APAR_RS01790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APAR_RS01800	COG0577	efflux transmembrane transporter activity
APAR_RS01800	COG1136	(ABC) transporter
APAR_RS01815	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APAR_RS01840	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APAR_RS01845	COG0205	6-phosphofructokinase activity
APAR_RS01850	COG0205	6-phosphofructokinase activity
APAR_RS01855	COG0148	phosphopyruvate hydratase activity
APAR_RS01865	COG3973	AAA domain
APAR_RS01870	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APAR_RS01880	COG1131	(ABC) transporter
APAR_RS01940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APAR_RS01950	COG0577	efflux transmembrane transporter activity
APAR_RS01950	COG1136	(ABC) transporter
APAR_RS01975	COG0210	DNA helicase
APAR_RS01985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APAR_RS01990	COG0306	phosphate transporter
APAR_RS02020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APAR_RS02035	COG1362	aminopeptidase activity
APAR_RS02045	COG0191	fructose-bisphosphate aldolase activity
APAR_RS02050	COG1959	2 iron, 2 sulfur cluster binding
APAR_RS02055	COG0822	iron-sulfur transferase activity
APAR_RS02060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APAR_RS02070	COG0719	Fe-S assembly protein
APAR_RS02075	COG0396	ATPase activity
APAR_RS02080	COG0124	histidyl-tRNA synthetase
APAR_RS02100	COG0577	efflux transmembrane transporter activity
APAR_RS02100	COG1136	(ABC) transporter
APAR_RS02105	COG1757	Na H antiporter
APAR_RS02110	COG0583	DNA-binding transcription factor activity
APAR_RS02115	COG0564	pseudouridine synthase activity
APAR_RS02160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APAR_RS02170	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APAR_RS02175	COG1132	(ABC) transporter
APAR_RS02180	COG1132	(ABC) transporter
APAR_RS02185	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APAR_RS02190	COG3708	Transcriptional regulator
APAR_RS02190	COG2207	Transcriptional regulator
APAR_RS02195	COG2814	Major facilitator Superfamily
APAR_RS02200	COG0588	phosphoglycerate mutase activity
APAR_RS02210	COG0174	glutamine synthetase
APAR_RS02215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APAR_RS02220	COG0765	amino acid transport
APAR_RS02230	COG0745	RESPONSE REGULATOR receiver
APAR_RS02235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APAR_RS02245	COG4555	ABC transporter
APAR_RS02255	COG1937	Protein conserved in bacteria
APAR_RS02260	COG2217	Heavy metal translocating P-type atpase
APAR_RS02265	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
APAR_RS02270	COG1397	ADP-ribosylglycohydrolase
APAR_RS02280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APAR_RS02290	COG0765	amino acid transport
APAR_RS02295	COG0765	amino acid transport
APAR_RS02300	COG1126	abc transporter atp-binding protein
APAR_RS02305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APAR_RS02320	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APAR_RS02340	COG1191	sigma factor activity
APAR_RS02350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APAR_RS02355	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APAR_RS02360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APAR_RS02365	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
APAR_RS02370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APAR_RS02380	COG0006	proline dipeptidase activity
APAR_RS02390	COG3715	PTS system
APAR_RS02395	COG3716	PTS system mannose fructose sorbose family IID component
APAR_RS02405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APAR_RS02415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APAR_RS02425	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
APAR_RS02430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APAR_RS02435	COG0497	DNA recombination
APAR_RS02440	COG0504	CTP synthase activity
APAR_RS02445	COG4974	Belongs to the 'phage' integrase family
APAR_RS02450	COG2001	Belongs to the MraZ family
APAR_RS02455	COG0275	rRNA processing
APAR_RS02465	COG0768	penicillin binding
APAR_RS02470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APAR_RS02475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APAR_RS02480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APAR_RS02485	COG0772	Belongs to the SEDS family
APAR_RS02490	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APAR_RS02495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APAR_RS02500	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APAR_RS02505	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
APAR_RS02510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APAR_RS02520	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APAR_RS02525	COG1799	cell septum assembly
APAR_RS02530	COG0762	integral membrane protein
APAR_RS02550	COG0617	tRNA 3'-terminal CCA addition
APAR_RS02555	COG1511	domain protein
APAR_RS02555	COG1511	domain protein
APAR_RS02590	COG1760	l-serine dehydratase
APAR_RS02595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APAR_RS02605	COG1362	aminopeptidase activity
APAR_RS02615	COG1132	(ABC) transporter
APAR_RS02640	COG0436	Aminotransferase
APAR_RS02655	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APAR_RS02665	COG0343	queuine tRNA-ribosyltransferase activity
APAR_RS02670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APAR_RS02670	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
APAR_RS02675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APAR_RS02680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APAR_RS02690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APAR_RS02695	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APAR_RS02700	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APAR_RS02705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APAR_RS02725	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APAR_RS02730	COG0018	arginyl-trna synthetase
APAR_RS02770	COG0410	ABC transporter
APAR_RS02775	COG0083	homoserine kinase activity
APAR_RS02790	COG0527	aspartate kinase activity
APAR_RS02795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APAR_RS02840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APAR_RS02910	COG0582	viral genome integration into host DNA
APAR_RS03065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APAR_RS03080	COG1105	Belongs to the carbohydrate kinase PfkB family
APAR_RS03090	COG1597	lipid kinase activity
APAR_RS03120	COG3842	ATPase activity
APAR_RS03125	COG1640	4-alpha-glucanotransferase
APAR_RS03130	COG0058	SHG alpha-glucan phosphorylase activity
APAR_RS03145	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APAR_RS03150	COG2094	Belongs to the DNA glycosylase MPG family
APAR_RS03155	COG0505	Belongs to the CarA family
APAR_RS03160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APAR_RS03175	COG0740	serine-type endopeptidase activity
APAR_RS03180	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APAR_RS03195	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APAR_RS03200	COG0525	valine-tRNA ligase activity
APAR_RS03205	COG2759	Belongs to the formate--tetrahydrofolate ligase family
APAR_RS03215	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APAR_RS03220	COG0302	gtp cyclohydrolase
APAR_RS03225	COG0285	dihydrofolate synthase activity
APAR_RS03235	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APAR_RS03240	COG0626	cystathionine gamma-synthase activity
APAR_RS03245	COG1454	alcohol dehydrogenase
APAR_RS03245	COG1012	belongs to the aldehyde dehydrogenase family
APAR_RS03290	COG1597	lipid kinase activity
APAR_RS03295	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
APAR_RS03300	COG2738	Putative neutral zinc metallopeptidase
APAR_RS03305	COG1570	exodeoxyribonuclease VII activity
APAR_RS03310	COG1722	exodeoxyribonuclease VII activity
APAR_RS03315	COG0537	adenosine 5'-monophosphoramidase activity
APAR_RS03320	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APAR_RS03330	COG0280	phosphate acetyltransferase
APAR_RS03335	COG0562	UDP-galactopyranose mutase
APAR_RS03355	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APAR_RS03360	COG0180	Tryptophanyl-tRNA synthetase
APAR_RS03365	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APAR_RS03370	COG1882	Formate acetyltransferase
APAR_RS03380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APAR_RS03385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APAR_RS03390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APAR_RS03400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APAR_RS03405	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APAR_RS03410	COG0352	thiamine-phosphate diphosphorylase activity
APAR_RS03415	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APAR_RS03425	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APAR_RS03435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APAR_RS03445	COG1077	Cell shape determining protein MreB Mrl
APAR_RS03460	COG0768	penicillin binding
APAR_RS03465	COG0772	Belongs to the SEDS family
APAR_RS03485	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APAR_RS03490	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APAR_RS03500	COG1122	ATPase activity
APAR_RS03505	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APAR_RS03510	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APAR_RS03515	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APAR_RS03520	COG1713	HD superfamily hydrolase involved in NAD metabolism
APAR_RS03525	COG0799	negative regulation of ribosome biogenesis
APAR_RS03550	COG0336	Belongs to the RNA methyltransferase TrmD family
APAR_RS03555	COG0681	Belongs to the peptidase S26 family
APAR_RS03560	COG0752	glycyl-tRNA synthetase alpha subunit
APAR_RS03565	COG0751	glycine-tRNA ligase activity
APAR_RS03570	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
APAR_RS03575	COG0574	Belongs to the PEP-utilizing enzyme family
APAR_RS03575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APAR_RS03580	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APAR_RS03590	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APAR_RS03595	COG0792	nuclease activity
APAR_RS03610	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
APAR_RS03615	COG4974	Belongs to the 'phage' integrase family
APAR_RS03620	COG0052	Belongs to the universal ribosomal protein uS2 family
APAR_RS03625	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APAR_RS03630	COG0528	UMP kinase activity
APAR_RS03635	COG0233	cytoplasmic translational termination
APAR_RS03640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APAR_RS03645	COG0575	Belongs to the CDS family
APAR_RS03650	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
APAR_RS03655	COG0750	zinc metalloprotease
APAR_RS03660	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APAR_RS03665	COG0442	prolyl-tRNA aminoacylation
APAR_RS03705	COG0488	(ABC) transporter
APAR_RS03710	COG1994	Peptidase M50
APAR_RS03720	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APAR_RS03725	COG1187	pseudouridine synthase activity
APAR_RS03730	COG0588	phosphoglycerate mutase activity
APAR_RS03735	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APAR_RS03740	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APAR_RS03750	COG1160	GTP binding
APAR_RS03755	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APAR_RS03760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APAR_RS03765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APAR_RS03780	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APAR_RS03790	COG0488	(ABC) transporter
APAR_RS03795	COG1132	(ABC) transporter
APAR_RS03800	COG1132	(ABC) transporter
APAR_RS03815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APAR_RS03815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APAR_RS03825	COG1151	hydroxylamine reductase activity
APAR_RS03830	COG0446	pyridine nucleotide-disulphide oxidoreductase
APAR_RS03835	COG2226	methyltransferase
APAR_RS03840	COG4716	Myosin-crossreactive antigen
APAR_RS03845	COG2226	methyltransferase
APAR_RS03850	COG0561	phosphatase activity
APAR_RS03865	COG1686	Belongs to the peptidase S11 family
APAR_RS03890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APAR_RS03905	COG2226	methyltransferase
APAR_RS03910	COG0456	acetyltransferase
APAR_RS03910	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
APAR_RS03915	COG0346	lactoylglutathione lyase activity
APAR_RS03920	COG2226	methyltransferase
APAR_RS03945	COG2252	PERMEase
APAR_RS03950	COG0756	dUTP diphosphatase activity
APAR_RS03955	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APAR_RS03965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APAR_RS03975	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APAR_RS03980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APAR_RS03985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APAR_RS03990	COG2359	stage V sporulation protein S
APAR_RS03995	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APAR_RS04000	COG1418	mRNA catabolic process
APAR_RS04010	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APAR_RS04015	COG1058	Belongs to the CinA family
APAR_RS04015	COG1546	Belongs to the CinA family
APAR_RS04020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APAR_RS04025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APAR_RS04030	COG1666	GTP binding
APAR_RS04045	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
APAR_RS04050	COG1185	polyribonucleotide nucleotidyltransferase activity
APAR_RS04065	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APAR_RS04070	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APAR_RS04085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APAR_RS04090	COG0484	heat shock protein binding
APAR_RS04095	COG0484	heat shock protein binding
APAR_RS04105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APAR_RS04115	COG0481	GTPase activity
APAR_RS04120	COG0268	Binds directly to 16S ribosomal RNA
APAR_RS04130	COG2333	competence protein COMEC
APAR_RS04130	COG0658	competence protein
APAR_RS04140	COG0301	tRNA thio-modification
APAR_RS04150	COG0194	GDP metabolic process
APAR_RS04160	COG0284	orotidine-5'-phosphate decarboxylase activity
APAR_RS04165	COG0167	dihydroorotate dehydrogenase activity
APAR_RS04170	COG0543	2 iron, 2 sulfur cluster binding
APAR_RS04175	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APAR_RS04180	COG0540	Belongs to the ATCase OTCase family
APAR_RS04185	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APAR_RS04195	COG1609	Transcriptional regulator
APAR_RS04210	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
APAR_RS04215	COG4211	Belongs to the binding-protein-dependent transport system permease family
APAR_RS04220	COG1129	ABC transporter
APAR_RS04225	COG1879	ABC-type sugar transport system periplasmic component
APAR_RS04235	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APAR_RS04245	COG0196	riboflavin kinase activity
APAR_RS04260	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APAR_RS04265	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APAR_RS04270	COG0195	Participates in both transcription termination and antitermination
APAR_RS04275	COG0779	Required for maturation of 30S ribosomal subunits
APAR_RS04280	COG0495	leucyl-tRNA aminoacylation
APAR_RS04285	COG0516	GMP reductase activity
APAR_RS04285	COG0517	IMP dehydrogenase activity
APAR_RS04310	COG0564	pseudouridine synthase activity
APAR_RS04320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APAR_RS04325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APAR_RS04330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APAR_RS04335	COG1395	domain, Protein
APAR_RS04355	COG2832	Protein of unknown function (DUF454)
APAR_RS04360	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APAR_RS04370	COG1196	nuclear chromosome segregation
APAR_RS04375	COG0571	ribonuclease III activity
APAR_RS04390	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APAR_RS04405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APAR_RS04415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APAR_RS04420	COG1461	Dihydroxyacetone kinase
APAR_RS04425	COG1302	Protein conserved in bacteria
APAR_RS04430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APAR_RS04445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APAR_RS04445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APAR_RS04450	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APAR_RS04460	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APAR_RS04475	COG3022	response to hydroperoxide
APAR_RS04490	COG1950	PFAM Membrane protein of
APAR_RS04495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APAR_RS04505	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APAR_RS04510	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APAR_RS04520	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APAR_RS04520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APAR_RS04540	COG1132	(ABC) transporter
APAR_RS04545	COG0546	phosphoglycolate phosphatase activity
APAR_RS04565	COG1278	Cold shock
APAR_RS04570	COG1376	ErfK ybiS ycfS ynhG family protein
APAR_RS04580	COG2255	four-way junction helicase activity
APAR_RS04585	COG0632	four-way junction helicase activity
APAR_RS04590	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
APAR_RS04600	COG2033	superoxide reductase activity
APAR_RS04605	COG0587	DNA-directed DNA polymerase activity
APAR_RS04610	COG3579	cysteine-type endopeptidase activity
APAR_RS04630	COG1739	Uncharacterized protein family UPF0029
APAR_RS04655	COG0450	alkyl hydroperoxide reductase
APAR_RS04680	COG0482	sulfurtransferase activity
APAR_RS04685	COG1104	cysteine desulfurase activity
APAR_RS04705	COG1366	Belongs to the anti-sigma-factor antagonist family
APAR_RS04750	COG0126	phosphoglycerate kinase activity
APAR_RS04760	COG1481	regulation of sporulation
APAR_RS04765	COG1660	Displays ATPase and GTPase activities
APAR_RS04770	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
APAR_RS04780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APAR_RS04795	COG4608	Belongs to the ABC transporter superfamily
APAR_RS04800	COG0444	Belongs to the ABC transporter superfamily
APAR_RS04810	COG0747	negative chemotaxis
APAR_RS04825	COG0322	excinuclease ABC activity
APAR_RS04835	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APAR_RS04840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APAR_RS04845	COG2731	YhcH YjgK YiaL family protein
APAR_RS04860	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
APAR_RS04865	COG0556	nucleotide-excision repair
APAR_RS04875	COG0237	dephospho-CoA kinase activity
APAR_RS04880	COG3842	ATPase activity
APAR_RS04900	COG2195	Cleaves the N-terminal amino acid of tripeptides
APAR_RS04905	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
APAR_RS04910	COG0747	negative chemotaxis
APAR_RS04915	COG4608	Belongs to the ABC transporter superfamily
APAR_RS04920	COG0444	Belongs to the ABC transporter superfamily
APAR_RS04925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APAR_RS04930	COG0601	transmembrane transport
APAR_RS04980	COG1846	Transcriptional regulator
APAR_RS04985	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APAR_RS04995	COG1918	ferrous iron import across plasma membrane
APAR_RS04995	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
APAR_RS05005	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APAR_RS05045	COG2084	Dehydrogenase
APAR_RS05050	COG1307	EDD domain protein, DegV family
APAR_RS05055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APAR_RS05065	COG1040	competence protein
APAR_RS05105	COG0717	Belongs to the dCTP deaminase family
APAR_RS05110	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
APAR_RS05115	COG0826	peptidase U32
APAR_RS05125	COG1216	Glycosyl transferase, family 2
APAR_RS05140	COG3475	LICD family
APAR_RS05155	COG4750	Nucleotidyl transferase
APAR_RS05160	COG3475	LICD family
APAR_RS05170	COG1091	dTDP-4-dehydrorhamnose reductase activity
APAR_RS05185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APAR_RS05190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APAR_RS05195	COG1438	arginine binding
APAR_RS05205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APAR_RS05210	COG0116	Belongs to the methyltransferase superfamily
APAR_RS05210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
APAR_RS05215	COG3158	transport of potassium into the cell
APAR_RS05225	COG3830	Belongs to the UPF0237 family
APAR_RS05310	COG2894	cell division
APAR_RS05320	COG1162	GTPase activity
APAR_RS05330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APAR_RS05340	COG1132	(ABC) transporter
APAR_RS05345	COG2375	cellular response to nickel ion
APAR_RS05345	COG1132	(ABC) transporter
APAR_RS05355	COG0745	RESPONSE REGULATOR receiver
APAR_RS05360	COG5002	protein histidine kinase activity
APAR_RS05360	COG3850	Histidine kinase
APAR_RS05370	COG0297	glycogen (starch) synthase activity
APAR_RS05375	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APAR_RS05380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APAR_RS05385	COG0058	SHG alpha-glucan phosphorylase activity
APAR_RS05390	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APAR_RS05395	COG0371	Dehydrogenase
APAR_RS05405	COG0072	phenylalanine-tRNA ligase activity
APAR_RS05410	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APAR_RS05415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APAR_RS05420	COG1121	(ABC) transporter
APAR_RS05425	COG0803	Belongs to the bacterial solute-binding protein 9 family
APAR_RS05430	COG2323	membrane
APAR_RS05445	COG2222	sugar isomerase
APAR_RS05450	COG2188	Transcriptional regulator
APAR_RS05455	COG3716	PTS system mannose fructose sorbose family IID component
APAR_RS05460	COG3715	PTS system
APAR_RS05465	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APAR_RS05470	COG1862	Preprotein translocase
APAR_RS05490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APAR_RS05495	COG3189	MarR family transcriptional regulator
APAR_RS05520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APAR_RS05520	COG2190	(PTS) system
APAR_RS05520	COG1263	PTS System
APAR_RS05525	COG0577	efflux transmembrane transporter activity
APAR_RS05525	COG0577	efflux transmembrane transporter activity
APAR_RS05530	COG1136	(ABC) transporter
APAR_RS05540	COG2205	protein histidine kinase activity
APAR_RS05545	COG0745	RESPONSE REGULATOR receiver
APAR_RS05555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APAR_RS05560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APAR_RS05560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APAR_RS05570	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APAR_RS05580	COG0720	synthase
APAR_RS05585	COG1774	PSP1 C-terminal conserved region
APAR_RS05595	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APAR_RS05600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APAR_RS05605	COG0805	protein transport
APAR_RS05610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APAR_RS05615	COG1366	Belongs to the anti-sigma-factor antagonist family
APAR_RS05625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APAR_RS05650	COG0328	RNA-DNA hybrid ribonuclease activity
APAR_RS05655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APAR_RS05655	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APAR_RS05670	COG1971	Probably functions as a manganese efflux pump
APAR_RS05680	COG1393	Belongs to the ArsC family
APAR_RS05720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APAR_RS05735	COG1979	alcohol dehydrogenase
APAR_RS05740	COG1307	EDD domain protein, DegV family
APAR_RS05755	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APAR_RS05755	COG1328	CTP reductase activity
APAR_RS05765	COG1216	Glycosyl transferase, family 2
APAR_RS05780	COG0101	tRNA pseudouridine synthase activity
APAR_RS05785	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APAR_RS05790	COG3845	ABC transporter
APAR_RS05795	COG0203	ribosomal protein L17
APAR_RS05805	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APAR_RS05810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APAR_RS05815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APAR_RS05835	COG0563	adenylate kinase activity
APAR_RS05850	COG1841	ribosomal large subunit assembly
APAR_RS05855	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APAR_RS05860	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APAR_RS05870	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APAR_RS05885	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APAR_RS05890	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APAR_RS05895	COG0255	Belongs to the universal ribosomal protein uL29 family
APAR_RS05900	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APAR_RS05905	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APAR_RS05910	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APAR_RS05915	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APAR_RS05920	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APAR_RS05925	COG0089	rRNA binding
APAR_RS05930	COG0088	Forms part of the polypeptide exit tunnel
APAR_RS05935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APAR_RS05945	COG0051	transcription antitermination factor activity, RNA binding
APAR_RS05950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APAR_RS05955	COG0049	tRNA binding
APAR_RS05960	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APAR_RS05975	COG0640	Transcriptional regulator
APAR_RS05980	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APAR_RS05985	COG0085	RNA polymerase activity
APAR_RS05990	COG0222	ribosome binding
APAR_RS05995	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APAR_RS06000	COG0081	regulation of translation
APAR_RS06005	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APAR_RS06010	COG0250	Participates in transcription elongation, termination and antitermination
APAR_RS06025	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APAR_RS06030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APAR_RS06065	COG0215	cysteine-tRNA ligase activity
APAR_RS06070	COG1132	(ABC) transporter
APAR_RS06075	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APAR_RS06080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APAR_RS06085	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
APAR_RS06095	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APAR_RS06100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APAR_RS06105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APAR_RS06115	COG0281	malic enzyme
APAR_RS06125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APAR_RS06130	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APAR_RS06140	COG0778	Nitroreductase
APAR_RS06160	COG1737	Transcriptional regulator
APAR_RS06165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
APAR_RS06175	COG1956	GAF domain-containing protein
APAR_RS06185	COG1164	Oligoendopeptidase f
APAR_RS06225	COG4268	DNA restriction-modification system
APAR_RS06260	COG1609	Transcriptional regulator
APAR_RS06265	COG2848	UPF0210 protein
APAR_RS06280	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APAR_RS06305	COG0025	NhaP-type Na H and K H
APAR_RS06335	COG5002	protein histidine kinase activity
APAR_RS06340	COG0745	RESPONSE REGULATOR receiver
APAR_RS06365	COG1335	isochorismatase
APAR_RS06370	COG0802	atpase or kinase
APAR_RS06375	COG1573	uracil-dna glycosylase
APAR_RS06380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APAR_RS06385	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APAR_RS06385	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APAR_RS06390	COG0736	holo-[acyl-carrier-protein] synthase activity
APAR_RS06395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APAR_RS06405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APAR_RS06415	COG1105	Belongs to the carbohydrate kinase PfkB family
APAR_RS06425	COG1396	sequence-specific DNA binding
APAR_RS06435	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APAR_RS06440	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APAR_RS06445	COG1621	beta-fructofuranosidase activity
APAR_RS06445	COG3583	domain protein
APAR_RS06445	COG5492	domain, Protein
APAR_RS06490	COG1695	Transcriptional regulator
APAR_RS06495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APAR_RS06515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APAR_RS06525	COG0557	exoribonuclease II activity
APAR_RS06530	COG0402	S-adenosylhomocysteine deaminase activity
APAR_RS06545	COG2177	Part of the ABC transporter FtsEX involved in
APAR_RS06550	COG2884	Cell division ATP-binding protein ftsE
APAR_RS06560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APAR_RS06590	COG1349	DNA-binding transcription factor activity
APAR_RS06595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
APAR_RS06600	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APAR_RS06605	COG0653	protein targeting
APAR_RS06630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APAR_RS06635	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APAR_RS06645	COG1316	TRANSCRIPTIONal
APAR_RS06650	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APAR_RS06665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APAR_RS06670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APAR_RS06680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APAR_RS06685	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APAR_RS06690	COG0356	it plays a direct role in the translocation of protons across the membrane
APAR_RS06700	COG0698	ribose 5-phosphate isomerase
APAR_RS06710	COG2890	protein-(glutamine-N5) methyltransferase activity
APAR_RS06715	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APAR_RS06725	COG0586	Pfam SNARE associated Golgi protein
APAR_RS06735	COG3716	PTS system mannose fructose sorbose family IID component
APAR_RS06740	COG3715	PTS system
APAR_RS06765	COG3118	belongs to the thioredoxin family
APAR_RS06770	COG0671	phosphoesterase, PA-phosphatase related
APAR_RS06780	COG3279	Response regulator of the LytR AlgR family
APAR_RS06785	COG3275	phosphorelay sensor kinase activity
APAR_RS06815	COG0138	bifunctional purine biosynthesis protein purh
APAR_RS06825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APAR_RS06830	COG5002	protein histidine kinase activity
APAR_RS06840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APAR_RS06840	COG1263	PTS System
APAR_RS06845	COG0366	Alpha amylase catalytic
APAR_RS06865	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APAR_RS06880	COG2815	serine threonine protein kinase
APAR_RS06880	COG0515	serine threonine protein kinase
APAR_RS06885	COG1716	ATPase activity
APAR_RS06885	COG1131	(ABC) transporter
APAR_RS06885	COG0842	Transport permease protein
APAR_RS06905	COG0515	serine threonine protein kinase
APAR_RS06905	COG2815	serine threonine protein kinase
APAR_RS06920	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APAR_RS06925	COG5002	protein histidine kinase activity
APAR_RS06930	COG0745	RESPONSE REGULATOR receiver
APAR_RS06940	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APAR_RS06985	COG1199	ATP-dependent helicase activity
APAR_RS06985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APAR_RS06990	COG1181	Belongs to the D-alanine--D-alanine ligase family
APAR_RS06995	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APAR_RS07005	COG1475	DNA binding
APAR_RS07010	COG1192	Involved in chromosome partitioning
APAR_RS07015	COG0357	Ribosomal RNA small subunit methyltransferase G
APAR_RS07020	COG1847	R3H domain protein
APAR_RS07025	COG0706	membrane insertase activity
APAR_RS07030	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
APAR_RS07040	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APAR_RS07070	COG3959	Transketolase, thiamine diphosphate binding domain
APAR_RS07090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APAR_RS07090	COG2207	Transcriptional regulator
APAR_RS07105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APAR_RS07140	COG1555	photosystem II stabilization
APAR_RS07140	COG1596	polysaccharide export
APAR_RS07145	COG2207	Transcriptional regulator
APAR_RS07180	COG1442	glycosyl transferase family 8
APAR_RS07190	COG1396	sequence-specific DNA binding